메뉴 건너뛰기




Volumn 107, Issue 50, 2010, Pages 21424-21429

Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

Author keywords

Diacylglyceride; Insig 1; Lipid droplet

Indexed keywords

DIACYLGLYCEROL; FAT DROPLET; MEMBRANE PROTEIN; TRIACYLGLYCEROL; TRYPSIN; UBXD8 PROTEIN; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

EID: 78650718129     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011859107     Document Type: Article
Times cited : (83)

References (24)
  • 1
    • 0026745069 scopus 로고
    • Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver
    • Ntambi JM (1992) Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver. J Biol Chem 267:10925-10930.
    • (1992) J Biol Chem , vol.267 , pp. 10925-10930
    • Ntambi, J.M.1
  • 2
    • 0035932990 scopus 로고    scopus 로고
    • Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
    • Ou J, et al. (2001) Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci USA 98:6027-6032.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6027-6032
    • Ou, J.1
  • 3
    • 0035830840 scopus 로고    scopus 로고
    • Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells
    • Hannah VC, Ou J, Luong A, Goldstein JL, Brown MS (2001) Unsaturated fatty acids down-regulate SREBP isoforms 1a and 1c by two mechanisms in HEK-293 cells. J Biol Chem 276:4365-4372.
    • (2001) J Biol Chem , vol.276 , pp. 4365-4372
    • Hannah, V.C.1    Ou, J.2    Luong, A.3    Goldstein, J.L.4    Brown, M.S.5
  • 4
    • 70449769682 scopus 로고    scopus 로고
    • Lipid droplets finally get a little R-E-S-P-E-C-T
    • Farese RV, Walther TC (2009) Lipid droplets finally get a little R-E-S-P-E-C-T. Cell 139:855-860.
    • (2009) Cell , vol.139 , pp. 855-860
    • Farese, R.V.1    Walther, T.C.2
  • 5
    • 57749114764 scopus 로고    scopus 로고
    • Unsaturated fatty acids inhibit proteasomal degradation of insig-1 at a post-ubiquitination step
    • Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J (2008) Unsaturated fatty acids inhibit proteasomal degradation of insig-1 at a post-ubiquitination step. J Biol Chem 283:33772-33783.
    • (2008) J Biol Chem , vol.283 , pp. 33772-33783
    • Lee, J.N.1    Zhang, X.2    Feramisco, J.D.3    Gong, Y.4    Ye, J.5
  • 6
    • 45549102437 scopus 로고    scopus 로고
    • Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells
    • Coll T, et al. (2008) Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J Biol Chem 283:11107-11116.
    • (2008) J Biol Chem , vol.283 , pp. 11107-11116
    • Coll, T.1
  • 7
    • 0142027805 scopus 로고    scopus 로고
    • Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    • Horton JD, et al. (2003) Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 100:12027-12032.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12027-12032
    • Horton, J.D.1
  • 8
    • 0033613147 scopus 로고    scopus 로고
    • A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
    • Brown MS, Goldstein JL (1999) A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 96:11041-11048.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11041-11048
    • Brown, M.S.1    Goldstein, J.L.2
  • 9
    • 0033599028 scopus 로고    scopus 로고
    • Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
    • DeBose-Boyd RA, et al. (1999) Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99:703-712.
    • (1999) Cell , vol.99 , pp. 703-712
    • Debose-Boyd, R.A.1
  • 10
    • 0037162719 scopus 로고    scopus 로고
    • Crucial step in cholesterol homeostasis: Sterols promote binding of Scap to Insig-1, a membrane protein that facilitates retention of SREBPs in ER
    • Yang T, et al. (2002) Crucial step in cholesterol homeostasis: Sterols promote binding of Scap to Insig-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110:489-500.
    • (2002) Cell , vol.110 , pp. 489-500
    • Yang, T.1
  • 11
    • 0036792050 scopus 로고    scopus 로고
    • Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
    • Yabe D, Brown MS, Goldstein JL (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA 99:12753-12758.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12753-12758
    • Yabe, D.1    Brown, M.S.2    Goldstein, J.L.3
  • 12
    • 5644244825 scopus 로고    scopus 로고
    • Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl- coenzyme A reductase
    • Sever N, Lee PCW, Song BL, Rawson RB, DeBose-Boyd RA (2004) Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 279:43136-43147.
    • (2004) J Biol Chem , vol.279 , pp. 43136-43147
    • Sever, N.1    Lee, P.C.W.2    Song, B.L.3    Rawson, R.B.4    Debose-Boyd, R.A.5
  • 14
    • 56749176947 scopus 로고    scopus 로고
    • One step at a time: Endoplasmic reticulum-associated degradation
    • Vembar S, Brodsky JL (2008) One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol 9:944-957.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 944-957
    • Vembar, S.1    Brodsky, J.L.2
  • 15
    • 71749117369 scopus 로고    scopus 로고
    • Regulated endoplasmic reticulum-associated degradation of a polytopic protein: P97 recruits proteasomes to Insig-1 before extraction from membranes
    • Ikeda Y, et al. (2009) Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. J Biol Chem 284:34889-34900.
    • (2009) J Biol Chem , vol.284 , pp. 34889-34900
    • Ikeda, Y.1
  • 16
    • 70350400618 scopus 로고    scopus 로고
    • Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets
    • Zehmer JK, et al. (2009) Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets. J Cell Sci 122:3694-3702.
    • (2009) J Cell Sci , vol.122 , pp. 3694-3702
    • Zehmer, J.K.1
  • 17
    • 0023652396 scopus 로고
    • A C-terminal signal prevents secretion of luminal ER proteins
    • Munro S, Pelham HRB (1987) A C-terminal signal prevents secretion of luminal ER proteins. Cell 48:899-907.
    • (1987) Cell , vol.48 , pp. 899-907
    • Munro, S.1    Pelham, H.R.B.2
  • 18
    • 0033215204 scopus 로고    scopus 로고
    • Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein
    • Rawson RB, DeBose-Boyd R, Goldstein JL, Brown MS (1999) Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein. J Biol Chem 274:28549-28556.
    • (1999) J Biol Chem , vol.274 , pp. 28549-28556
    • Rawson, R.B.1    Debose-Boyd, R.2    Goldstein, J.L.3    Brown, M.S.4
  • 20
    • 0021742599 scopus 로고
    • The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
    • Yamamoto T, et al. (1984) The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA. Cell 39:27-38.
    • (1984) Cell , vol.39 , pp. 27-38
    • Yamamoto, T.1
  • 22
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • Unger RH (2002) Lipotoxic diseases. Annu Rev Med 53:319-336.
    • (2002) Annu Rev Med , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 23
    • 77950543816 scopus 로고    scopus 로고
    • Diacylglycerol-mediated insulin resistance
    • Erion DM, Shulman GI (2010) Diacylglycerol-mediated insulin resistance. Nat Med 16:400-402.
    • (2010) Nat Med , vol.16 , pp. 400-402
    • Erion, D.M.1    Shulman, G.I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.