Amplified Inhibition of Stellate Cell Activation Pathways by PPAR-γ, RAR and RXR Agonists

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Sharvit, Efrat ^a,b   Abramovitch, Shirley ^a   Reif, Shimon ^a   Bruck, Rafael ^a,b  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

15 DELTA 12,13 PROSTAGLANDIN L2; ALITRETINOIN; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN IALPHA1; COLLAGEN TYPE 1; CYCLIN D1; FAT DROPLET; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROTEIN P21; PROTEIN P27; RETINOIC ACID; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENTIATION; FLUORESCENCE ACTIVATED CELL SORTING; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

ACTINS; ANIMALS; CELL PROLIFERATION; COLLAGEN TYPE I; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DRUG SYNERGISM; G1 PHASE; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; MALE; PPAR GAMMA; PRIMARY CELL CULTURE; PROSTAGLANDIN D2; RATS; RATS, WISTAR; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; RHO GTP-BINDING PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRETINOIN;

EID: 84884871131     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076541     Document Type: Article

References (33)

1. Glass CK, Ogawa S, (2006) Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 6: 44-55. doi:10.1038/nri1748. PubMed: 16493426.
2. Hazra S, Xiong S, Wang J, Rippe RA, Krishna V, et al. (2004) Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 279(12):: 11392-11401. doi:10.1074/jbc.M310284200. PubMed: 14702344.
3. Marra F, Efsen E, Romanelli RG, Caligiuri A, Pastacaldi S, et al. (2000) Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology 119: 466-478. doi:10.1053/gast.2000.9365. PubMed: 10930382.
4. Pratt MAC, Niu M, White D, (2003) Differential regulation of protein expression, growth and apoptosis by natural and synthetic retinoids. J Cell Biochem 90: 692-708. doi:10.1002/jcb.10682. PubMed: 14587026.
5. Galli A, Crabb DW, Ceni E, Salzano R, Mello T, et al. (2002) Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology 122: 1924-1940. doi:10.1053/gast.2002.33666. PubMed: 12055599.
6. Toyota M, Miyazaki Y, Kitamura S, Nagasawa Y, Kiyohara T, et al. (2002) Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1. Life Sci 70(13):: 1565-1575. doi:10.1016/S0024-3205(01)01524-7. PubMed: 11895107.
7. Da Silva Morais A, Abarca-Quinones J, Horsmans Y, Stärkel P, Leclercq LA, (2007) Peroxisome proliferated-activated receptor γ ligand, Piolitazone, does not prevent hepatic fibrosis in mice. Int J Mol Med 19: 105-112. PubMed: 17143554.
8. Hellemans K, Grinko I, Rombouts K, Schuppan D, Geerts A, (1999) All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially. Gut 45: 134-142. doi:10.1136/gut.45.1.134. PubMed: 10369717.
9. Hisamori S, Tabata C, Kadokawa Y, Okoshi K, Tabata R, et al. (2008) All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production. Liver Int 28: 1217-1225. PubMed: 18397230.
10. Bruck R, Weiss S, Aeed H, Pines M, Halpern Z, et al. (2009) Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor γ and retinoic acid receptor. Dig Dis Sci 54: 292-299. doi:10.1007/s10620-008-0336-5. PubMed: 18594976.
11. Mangelsdorf DJ, Evans RM, (1995) The RXR heterodimers and orphan receptors. Cell 83: 841-850. doi:10.1016/0092-8674(95)90200-7. PubMed: 8521508.
12. Sun K, Wang Q, Huang XH, (2006) PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression. Acta Pharm Sinicia 27(6):: 715-723. doi:10.1111/j.1745-7254.2006.00299.x. PubMed: 16723090.
13. Blaner WS, O'Byrne SM, Wongsiriroj N, Kluwe J, D'Ambrosio DM, et al. (2009) Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage. Biochim Biophys Acta 1791(6):: 467-473. doi:10.1016/j.bbalip.2008.11.001. PubMed: 19071229.
14. Karpen SJ, (2002) Nuclear receptor regulation of hepatic function. J Hepatol 36: 832-850. doi:10.1016/S0168-8278(02)00129-0. PubMed: 12044537.
15. Glass CK, Rosenfeld MG, (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14: 121-141. PubMed: 10652267.
16. Liu H, Zang C, Fenner MH, Possinger K, Elstner E, (2003) PPARγ ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. Breast Cancer Res Treat 79: 63-74. doi:10.1023/A:1023366117157. PubMed: 12779083.
17. Lee YR, Yu HN, Noh EM, Kim JS, Song EK, et al. (2007) Peroxisome proliferator-activated receptor γ and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells. Int J Hematol 85: 231-237. doi:10.1532/IJH97.A30615. PubMed: 17483060.
18. Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF Jr, et al. (2000) Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem 275: 35715-35722. doi:10.1074/jbc.M006577200. PubMed: 10969082.
19. Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF Jr, et al. (2000) Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem 275: 35715-35722. doi:10.1074/jbc.M006577200. PubMed: 10969082.
20. Fujiyoshi M, Ozaki M, (2011) Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases. J Hepatobiliary Pancreat Sci 18: 13-22. doi:10.1007/s00534-010-0304-2. PubMed: 20607568.
21. Hao LS, Zhang XL, An JY, Karlin J, Tian XP, et al. (2009) PTEN expression is down-regulated in liver tissues of rats with hepatic fibrosis induced by biliary stenosis. APMIS 117: 681-691. doi:10.1111/j.1600-0463.2009.02515.x. PubMed: 19703128.
22. Hao LS, Zhang XL, An JY, Karlin J, Tian XP, et al. (2009) PTEN expression is down-regulated in liver tissues of rats with hepatic fibrosis induced by biliary stenosis. APMIS 117: 681-691. doi:10.1111/j.1600-0463.2009.02515.x. PubMed: 19703128.
23. Wynn TA, (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214: 199-210. doi:10.1002/path.2277. PubMed: 18161745.
24. Tsujie M, Nakamori S, Okami J, Takahashi Y, Hayashi N, et al. (2003) Growth inhibition of pancreatic cancer cells through activation of peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha pathway. Int J Oncol 23(2):: 325-331. PubMed: 12851681.
25. White ES, Thannickal VJ, Carskadon SL, Dickie EG, Livant DL, et al. (2003) Integrin α4β1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10. Am J Respir Cril Care Med 168(4):: 436-442. doi:10.1164/rccm.200301-041OC.
26. Lee SJ, Yang EK, Kim SG, (2006) Peroxisome proliferators-activated receptor-γ and retinoic acid X receptor α represses the TGFβ1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role of Zf9 dephosphorylation. Mol Pharm 70: 415-425.
27. Zhou Y, Zheng S, Lin J, Zhang QJ, Chen A, (2007) The interruption of PDGF and EGF signaling pathways by cucrumin stimulates gene expression of PPARγ in rat activated hepatic stellate cell in vitro. Lab Inves 87: 488-498.
28. Ravid A, Koren R, Narinsky R, Rotem C, Novogrodsky A, et al. (1990) 1,25-dihydroxyvitamin D3 and agents that increase intracellular adenosine 3',5'-monophosphate synergistically inhibit the mitogenic stimulation of human lymphocytes. J Clin Endocrinol Metab 70: 1687-1692. doi:10.1210/jcem-70-6-1687. PubMed: 1693374.
29. Cang Q, Chen Z, You J, McNutt MA, Zhang T, et al. (2007) All-trans-retinoic acid induce cell growth arrest in a human medulloblastoma cell line. J Neuro Oncol 84(3):: 263-267. doi:10.1007/s11060-007-9380-9.
30. Zang C, Wächter M, Liu H, Posch MG, Fenner MH, et al. (2003) Ligands for PPARγ and RAR cause induction of inhibition and apoptosis in human glioblastomas. J Neuro Onco 65: 107-118. doi:10.1023/B:NEON.0000003728.80052.a8.
31. Gäbele E, Reif S, Tsukada S, Bataller R, Yutaka Y, et al. (2005) The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 280(14):: 13374-13382. doi:10.1074/jbc.M409444200. PubMed: 15677443.
32. Imai K, Sato M, Kojima N, Miura M, Sato T, et al. (2000) Storage of lipid droplets in and production of extracellular matrix by hepatic stellate cells (vitamin A-storing cells) in long-evans cinnamon-like colored (LEC) rats. Anat Rec 258: 338-348. doi:10.1002/(SICI)1097-0185(20000401)258:4. PubMed: 10737852.
33. Friedman SL, Wei S, Blaner WS, (1993) Retinol release by activated rat hepatic lipocytes: regulation by kupffer cell-conditioned medium and PDGF. Am J Physiol 264: G947-G952. PubMed: 8498521.