메뉴 건너뛰기




Volumn 67, Issue 8, 2006, Pages 643-650

Stearoyl-CoA desaturase: A new therapeutic target of liver steatosis

Author keywords

Atherosclerosis; Fatty acid oxidation; Fatty liver disease; Lipogenesis; Stearoyl co desaturase

Indexed keywords

ACYL COENZYME A DESATURASE; ESTER DERIVATIVE; ISOENZYME; LEPTIN; MONOUNSATURATED FATTY ACID; OLEIC ACID; PALMITOLEOATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHOLIPID DERIVATIVE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; WAX;

EID: 33845263672     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20139     Document Type: Review
Times cited : (17)

References (54)
  • 1
    • 0035965565 scopus 로고    scopus 로고
    • Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia
    • Agatha G, Hafer R, Zintl F. 2001. Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. Cancer Lett 173:139-144.
    • (2001) Cancer Lett , vol.173 , pp. 139-144
    • Agatha, G.1    Hafer, R.2    Zintl, F.3
  • 2
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. 2002. Nonalcoholic fatty liver disease. N Engl J Med 346:1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 3
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • (Lond)
    • Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P, Poniachik J. 2004. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 106:635-643.
    • (2004) Clin Sci , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6    Poniachik, J.7
  • 6
    • 0037464551 scopus 로고    scopus 로고
    • Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip
    • Beiraghi S, Zhou M, Talmadge CB, Went-Sumegi N, Davis JR, Huang D, Saal H, Seemayer TA, Sumegi J. 2003. Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip. Gene 309:11-21.
    • (2003) Gene , vol.309 , pp. 11-21
    • Beiraghi, S.1    Zhou, M.2    Talmadge, C.B.3    Went-Sumegi, N.4    Davis, J.R.5    Huang, D.6    Saal, H.7    Seemayer, T.A.8    Sumegi, J.9
  • 8
    • 0034770290 scopus 로고    scopus 로고
    • Turning WAT into BAT gets rid of fat
    • Chen HC, Farese RV Jr. 2001. Turning WAT into BAT gets rid of fat. Nat Med 7:1102-1103.
    • (2001) Nat Med , vol.7 , pp. 1102-1103
    • Chen, H.C.1    Farese Jr., R.V.2
  • 10
    • 1542404084 scopus 로고    scopus 로고
    • The role of stearoyl-CoA desaturase in body weight regulation
    • Dobrzyn A, Ntambi JM. 2004. The role of stearoyl-CoA desaturase in body weight regulation. Trends Cardiovasc Med 14:77-81.
    • (2004) Trends Cardiovasc Med , vol.14 , pp. 77-81
    • Dobrzyn, A.1    Ntambi, J.M.2
  • 12
    • 18044388542 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase as a new drug target for obesity treatment
    • Dobrzyn A, Ntambi JM. 2005b. Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obes Rev 6:169-174.
    • (2005) Obes Rev , vol.6 , pp. 169-174
    • Dobrzyn, A.1    Ntambi, J.M.2
  • 15
    • 19744379230 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues
    • Dobrzyn A, Dobrzyn P, Miyazaki M, Ntambi JM. 2005b. Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues. Biochem Biophys Res Commun 332:892-896.
    • (2005) Biochem Biophys Res Commun , vol.332 , pp. 892-896
    • Dobrzyn, A.1    Dobrzyn, P.2    Miyazaki, M.3    Ntambi, J.M.4
  • 16
    • 19744379323 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency increases CTP: Choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver
    • Dobrzyn A, Dobrzyn P, Miyazaki M, Sampath H, Chu K, Ntambi JM. 2005c. Stearoyl-CoA desaturase 1 deficiency increases CTP: choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J Biol Chem 280:23356-23362.
    • (2005) J Biol Chem , vol.280 , pp. 23356-23362
    • Dobrzyn, A.1    Dobrzyn, P.2    Miyazaki, M.3    Sampath, H.4    Chu, K.5    Ntambi, J.M.6
  • 17
    • 0017181438 scopus 로고
    • Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid
    • Enoch HG, Catala A, Strittmatter P. 1976. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. J Biol Chem 251:5095-5103.
    • (1976) J Biol Chem , vol.251 , pp. 5095-5103
    • Enoch, H.G.1    Catala, A.2    Strittmatter, P.3
  • 19
    • 0842269198 scopus 로고    scopus 로고
    • Hepatic steatosis in obese patients: Clinical aspects and prognostic significance
    • Festi D, Colecchia A, Sacco T, Bondi M, Roda E, Marchesini G. 2004. Hepatic steatosis in obese patients: clinical aspects and prognostic significance. Obes Rev 5:27-42.
    • (2004) Obes Rev , vol.5 , pp. 27-42
    • Festi, D.1    Colecchia, A.2    Sacco, T.3    Bondi, M.4    Roda, E.5    Marchesini, G.6
  • 21
    • 0033964872 scopus 로고    scopus 로고
    • Lipodystrophies
    • Garg A. 2000. Lipodystrophies. Am J Med 108:143-152.
    • (2000) Am J Med , vol.108 , pp. 143-152
    • Garg, A.1
  • 22
    • 3142583174 scopus 로고    scopus 로고
    • Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha)
    • Guzman M, Lo Verme J, Fu J, Oveisi F, Blazquez C, Piomelli D. 2004. Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J Biol Chem 279:27849-27854.
    • (2004) J Biol Chem , vol.279 , pp. 27849-27854
    • Guzman, M.1    Lo Verme, J.2    Fu, J.3    Oveisi, F.4    Blazquez, C.5    Piomelli, D.6
  • 23
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway - New players upstream and downstream
    • Hardie DG. 2004. The AMP-activated protein kinase pathway - new players upstream and downstream. J Cell Sci 117:5479-5487.
    • (2004) J Cell Sci , vol.117 , pp. 5479-5487
    • Hardie, D.G.1
  • 24
    • 0029809472 scopus 로고    scopus 로고
    • Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids
    • Jones BH, Maher MA, Banz WJ, Zemel MB, Whelan J, Smith PJ, Moustaid N. 1996. Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids. Am J Physiol 271:E44-E49.
    • (1996) Am J Physiol , vol.271
    • Jones, B.H.1    Maher, M.A.2    Banz, W.J.3    Zemel, M.B.4    Whelan, J.5    Smith, P.J.6    Moustaid, N.7
  • 25
    • 0024427057 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase
    • Kaestner KH, Ntambi JM, Kelly TJ Jr, Lane MD. 1989. Differentiation- induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem 264:14755-14761.
    • (1989) J Biol Chem , vol.264 , pp. 14755-14761
    • Kaestner, K.H.1    Ntambi, J.M.2    Kelly Jr., T.J.3    Lane, M.D.4
  • 26
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. 1999. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103:1489-1498.
    • (1999) J Clin Invest , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 27
    • 4644340815 scopus 로고    scopus 로고
    • Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
    • Lee SH, Dobrzyn A, Dobrzyn P, Rahman SM, Miyazaki M, Ntambi JM. 2004. Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J Lipid Res 45:1674-1682.
    • (2004) J Lipid Res , vol.45 , pp. 1674-1682
    • Lee, S.H.1    Dobrzyn, A.2    Dobrzyn, P.3    Rahman, S.M.4    Miyazaki, M.5    Ntambi, J.M.6
  • 28
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K, Giacca A. 2002. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23:201-229.
    • (2002) Endocr Rev , vol.23 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 31
    • 0034730532 scopus 로고    scopus 로고
    • The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
    • Miyazaki M, Kim YC, Gray-Keller MP, Attie AD, Ntambi JM. 2000. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J Biol Chem 275:30132-30138.
    • (2000) J Biol Chem , vol.275 , pp. 30132-30138
    • Miyazaki, M.1    Kim, Y.C.2    Gray-Keller, M.P.3    Attie, A.D.4    Ntambi, J.M.5
  • 32
    • 0034958783 scopus 로고    scopus 로고
    • A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
    • Miyazaki M, Kim YC, Ntambi JM. 2001. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J Lipid Res 42:1018-1024.
    • (2001) J Lipid Res , vol.42 , pp. 1018-1024
    • Miyazaki, M.1    Kim, Y.C.2    Ntambi, J.M.3
  • 33
    • 0141780830 scopus 로고    scopus 로고
    • Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
    • Miyazaki M, Jacobson MJ, Man WC, Cohen P, Asilmaz E, Friedman JM, Ntambi JM. 2003. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem 278:33904-33911.
    • (2003) J Biol Chem , vol.278 , pp. 33904-33911
    • Miyazaki, M.1    Jacobson, M.J.2    Man, W.C.3    Cohen, P.4    Asilmaz, E.5    Friedman, J.M.6    Ntambi, J.M.7
  • 34
    • 2942588527 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    • Miyazaki M, Dobrzyn A, Man WC, Chu K, Sampath H, Kim HJ, Ntambi JM . 2004a. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J Biol Chem 279:25164-25171.
    • (2004) J Biol Chem , vol.279 , pp. 25164-25171
    • Miyazaki, M.1    Dobrzyn, A.2    Man, W.C.3    Chu, K.4    Sampath, H.5    Kim, H.J.6    Ntambi, J.M.7
  • 35
    • 4544231849 scopus 로고    scopus 로고
    • Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha
    • Miyazaki M, Dobrzyn A, Sampath H, Lee SH, Man WC, Chu K, Peters JM, Gonzalez FJ, Ntambi JM. 2004b. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. J Biol Chem 279:35017-35024.
    • (2004) J Biol Chem , vol.279 , pp. 35017-35024
    • Miyazaki, M.1    Dobrzyn, A.2    Sampath, H.3    Lee, S.H.4    Man, W.C.5    Chu, K.6    Peters, J.M.7    Gonzalez, F.J.8    Ntambi, J.M.9
  • 36
    • 24644458630 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development
    • Miyazaki M, Dobrzyn A, Elias PM, Ntambi JM. 2005. Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc Natl Acad Sci USA 102:12501-12506.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12501-12506
    • Miyazaki, M.1    Dobrzyn, A.2    Elias, P.M.3    Ntambi, J.M.4
  • 38
    • 0345276007 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturases and role in metabolism
    • Ntambi JM, Miyazaki M. 2004. Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res 43:91-104.
    • (2004) Prog Lipid Res , vol.43 , pp. 91-104
    • Ntambi, J.M.1    Miyazaki, M.2
  • 39
    • 0024297268 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase
    • Ntambi JM, Buhrow SA, Kaestner KH, Christy RJ, Sibley E, Kelly TJ Jr, Lane MD. 1988. Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem 263:17291-17300.
    • (1988) J Biol Chem , vol.263 , pp. 17291-17300
    • Ntambi, J.M.1    Buhrow, S.A.2    Kaestner, K.H.3    Christy, R.J.4    Sibley, E.5    Kelly Jr., T.J.6    Lane, M.D.7
  • 41
    • 12344266711 scopus 로고    scopus 로고
    • Regulation of stearoyl-CoA desaturase expression
    • Ntambi JM, Miyazaki M, Dobrzyn A. 2004. Regulation of stearoyl-CoA desaturase expression. Lipids 39:1061-1065.
    • (2004) Lipids , vol.39 , pp. 1061-1065
    • Ntambi, J.M.1    Miyazaki, M.2    Dobrzyn, A.3
  • 42
    • 0027938409 scopus 로고
    • Dietary fats, membrane phospholipids and obesity
    • Pan DA, Hulbert AJ, Storlein LH. 1994. Dietary fats, membrane phospholipids and obesity. J Nutr 124:1555-1565.
    • (1994) J Nutr , vol.124 , pp. 1555-1565
    • Pan, D.A.1    Hulbert, A.J.2    Storlein, L.H.3
  • 44
    • 0141813781 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle
    • Rahman SM, Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Ntambi JM. 2003. Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci USA 100:11110-11115.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11110-11115
    • Rahman, S.M.1    Dobrzyn, A.2    Dobrzyn, P.3    Lee, S.H.4    Miyazaki, M.5    Ntambi, J.M.6
  • 46
    • 0032567445 scopus 로고    scopus 로고
    • Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
    • Shimomura I, Shimano H, Korn BS, Bashmakov Y, Horton JD. 1998. Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. J Biol Chem 273:35299-35306.
    • (1998) J Biol Chem , vol.273 , pp. 35299-35306
    • Shimomura, I.1    Shimano, H.2    Korn, B.S.3    Bashmakov, Y.4    Horton, J.D.5
  • 48
    • 0026561011 scopus 로고
    • Factors influencing triacylglycerol synthesis in permeabilized rat hepatocytes
    • Stals HK, Mannaerts GP, Declercq PE. 1992. Factors influencing triacylglycerol synthesis in permeabilized rat hepatocytes. Biochem J 283:719-725.
    • (1992) Biochem J , vol.283 , pp. 719-725
    • Stals, H.K.1    Mannaerts, G.P.2    Declercq, P.E.3
  • 49
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW. 1991. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 40:280-289.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3    Pascoe, W.S.4    Khouri, S.5    Kraegen, E.W.6
  • 50
    • 0037458568 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure
    • Sun Y, Hao M, Luo Y, Liang CP, Silver DL, Cheng C, Maxfield FR, Tall AR. 2003. Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure. J Biol Chem 278:5813-5820.
    • (2003) J Biol Chem , vol.278 , pp. 5813-5820
    • Sun, Y.1    Hao, M.2    Luo, Y.3    Liang, C.P.4    Silver, D.L.5    Cheng, C.6    Maxfield, F.R.7    Tall, A.R.8
  • 51
    • 0021436667 scopus 로고
    • Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise
    • Wahren J, Sato Y, Ostman J, Hagenfeldt L, Felig P. 1984. Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise. J Clin Invest 73:1367-1376.
    • (1984) J Clin Invest , vol.73 , pp. 1367-1376
    • Wahren, J.1    Sato, Y.2    Ostman, J.3    Hagenfeldt, L.4    Felig, P.5
  • 52
    • 0033563109 scopus 로고    scopus 로고
    • Human stearoyl-CoA desaturase: Alternative transcripts generated from a single gene by usage of tandem polyadenylation sites
    • Zhang L, Ge L, Parimoo S, Stenn K, Prouty SM. 1999. Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J 340:255-264.
    • (1999) Biochem J , vol.340 , pp. 255-264
    • Zhang, L.1    Ge, L.2    Parimoo, S.3    Stenn, K.4    Prouty, S.M.5
  • 54
    • 0035862555 scopus 로고    scopus 로고
    • Scd3: A novel gene of the stearoyl-CoA desaturase family with restricted expression in skin
    • Zheng Y, Prouty SM, Harmon A, Sundberg JP, Stenn KS, Parimoo S. 2001. Scd3: a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Genomics 71:182-191.
    • (2001) Genomics , vol.71 , pp. 182-191
    • Zheng, Y.1    Prouty, S.M.2    Harmon, A.3    Sundberg, J.P.4    Stenn, K.S.5    Parimoo, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.