-
1
-
-
75449094816
-
Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
-
Fabbrini, E., Sullivan, S., and Klein, S. (2010) Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51, 679-689
-
(2010)
Hepatology
, vol.51
, pp. 679-689
-
-
Fabbrini, E.1
Sullivan, S.2
Klein, S.3
-
2
-
-
70349326750
-
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
-
Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., and Klein, S. (2009) Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc. Natl. Acad. Sci. U. S. A. 106, 15430-15435
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 15430-15435
-
-
Fabbrini, E.1
Magkos, F.2
Mohammed, B.S.3
Pietka, T.4
Abumrad, N.A.5
Patterson, B.W.6
Okunade, A.7
Klein, S.8
-
3
-
-
49449092403
-
Identification and characterization of metabolically benign obesity in humans
-
Stefan, N., Kantartzis, K., Machann, J., Schick, F., Thamer, C., Rittig, K., Balletshofer, B., Machicao, F., Fritsche, A., and Haring, H. U. (2008) Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 168, 1609-1616
-
(2008)
Arch. Intern. Med.
, vol.168
, pp. 1609-1616
-
-
Stefan, N.1
Kantartzis, K.2
Machann, J.3
Schick, F.4
Thamer, C.5
Rittig, K.6
Balletshofer, B.7
Machicao, F.8
Fritsche, A.9
Haring, H.U.10
-
4
-
-
8844226709
-
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
-
DOI 10.1126/science.1100747
-
Zimmermann, R., Strauss, J. G., Haemmerle, G., Schoiswohl, G., Birner-Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., and Zechner, R. (2004) Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306, 1383-1386 (Pubitemid 39532517)
-
(2004)
Science
, vol.306
, Issue.5700
, pp. 1383-1386
-
-
Zimmermann, R.1
Strauss, J.G.2
Haemmerle, G.3
Schoiswohl, G.4
Birner-Gruenberger, R.5
Riederer, M.6
Lass, A.7
Neuberger, G.8
Eisenhaber, F.9
Hermetter, A.10
Zechner, R.11
-
5
-
-
8744297386
-
Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: Ectopic expression of desnutrin increases triglyceride hydrolysis
-
DOI 10.1074/jbc.M403855200
-
Villena, J. A., Roy, S., Sarkadi-Nagy, E., Kim, K. H., and Sul, H. S. (2004) Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J. Biol. Chem. 279, 47066-47075 (Pubitemid 39518362)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.45
, pp. 47066-47075
-
-
Villena, J.A.1
Roy, S.2
Sarkadi-Nagy, E.3
Kim, K.-H.4
Hei, S.S.5
-
6
-
-
10344262633
-
2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
-
DOI 10.1074/jbc.M407841200
-
Jenkins, C. M., Mancuso, D. J., Yan, W., Sims, H. F., Gibson, B., and Gross, R. W. (2004) Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J. Biol. Chem. 279, 48968-48975 (Pubitemid 39625778)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.47
, pp. 48968-48975
-
-
Jenkins, C.M.1
Mancuso, D.J.2
Yan, W.3
Sims, H.F.4
Gibson, B.5
Gross, R.W.6
-
7
-
-
78751496304
-
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
-
Ong, K. T., Mashek, M. T., Bu, S. Y., Greenberg, A. S., and Mashek, D. G. (2011) Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning. Hepatology 53, 116-126
-
(2011)
Hepatology
, vol.53
, pp. 116-126
-
-
Ong, K.T.1
Mashek, M.T.2
Bu, S.Y.3
Greenberg, A.S.4
Mashek, D.G.5
-
8
-
-
79959550724
-
Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
-
Wu, J. W., Wang, S. P., Alvarez, F., Casavant, S., Gauthier, N., Abed, L., Soni, K. G., Yang, G., and Mitchell, G. A. (2011) Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology 54, 122-132
-
(2011)
Hepatology
, vol.54
, pp. 122-132
-
-
Wu, J.W.1
Wang, S.P.2
Alvarez, F.3
Casavant, S.4
Gauthier, N.5
Abed, L.6
Soni, K.G.7
Yang, G.8
Mitchell, G.A.9
-
9
-
-
33646462136
-
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
-
Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S., Kratky, D., Wagner, E. F., Klingenspor, M., Hoefler, G., and Zechner, R. (2006) Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 312, 734-737
-
(2006)
Science
, vol.312
, pp. 734-737
-
-
Haemmerle, G.1
Lass, A.2
Zimmermann, R.3
Gorkiewicz, G.4
Meyer, C.5
Rozman, J.6
Heldmaier, G.7
Maier, R.8
Theussl, C.9
Eder, S.10
Kratky, D.11
Wagner, E.F.12
Klingenspor, M.13
Hoefler, G.14
Zechner, R.15
-
10
-
-
71049114611
-
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling
-
Kienesberger, P. C., Lee, D., Pulinilkunnil, T., Brenner, D. S., Cai, L., Magnes, C., Koefeler, H. C., Streith, I. E., Rechberger, G. N., Haemmerle, G., Flier, J. S., Zechner, R., Kim, Y. B., and Kershaw, E. E. (2009) Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J. Biol. Chem. 284, 30218-30229
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 30218-30229
-
-
Kienesberger, P.C.1
Lee, D.2
Pulinilkunnil, T.3
Brenner, D.S.4
Cai, L.5
Magnes, C.6
Koefeler, H.C.7
Streith, I.E.8
Rechberger, G.N.9
Haemmerle, G.10
Flier, J.S.11
Zechner, R.12
Kim, Y.B.13
Kershaw, E.E.14
-
11
-
-
79953787445
-
Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
-
Turpin, S. M., Hoy, A. J., Brown, R. D., Rudaz, C. G., Honeyman, J., Matzaris, M., and Watt, M. J. (2011) Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia 54, 146-156
-
(2011)
Diabetologia
, vol.54
, pp. 146-156
-
-
Turpin, S.M.1
Hoy, A.J.2
Brown, R.D.3
Rudaz, C.G.4
Honeyman, J.5
Matzaris, M.6
Watt, M.J.7
-
12
-
-
33847714769
-
Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase a-stimulated lipolysis in adipocytes
-
DOI 10.1074/jbc.M605770200
-
Miyoshi, H., Perfield, J. W., 2nd, Souza, S. C., Shen, W. J., Zhang, H. H., Stancheva, Z. S., Kraemer, F. B., Obin, M. S., and Greenberg, A. S. (2007) Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes. J. Biol. Chem. 282, 996-1002 (Pubitemid 47076543)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.2
, pp. 996-1002
-
-
Miyoshi, H.1
Perfield II, J.W.2
Souza, S.C.3
Shen, W.-J.4
Zhang, H.-H.5
Stancheva, Z.S.6
Kraemer, F.B.7
Obin, M.S.8
Greenberg, A.S.9
-
13
-
-
4043077961
-
Molecular mediators of hepatic steatosis and liver injury
-
DOI 10.1172/JCI200422422
-
Browning, J. D., and Horton, J. D. (2004) Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 114, 147-152 (Pubitemid 39071617)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.2
, pp. 147-152
-
-
Browning, J.D.1
Horton, J.D.2
-
14
-
-
70449158340
-
A simple method for the isolation and purification of total lipides from animal tissues
-
Folch, J., Lees, M., and Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497-509
-
(1957)
J. Biol. Chem.
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Sloane Stanley, G.H.3
-
15
-
-
0026602267
-
Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
-
Mitrakou, A., Kelley, D., Mokan, M., Veneman, T., Pangburn, T., Reilly, J., and Gerich, J. (1992) Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N. Engl. J. Med. 326, 22-29
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 22-29
-
-
Mitrakou, A.1
Kelley, D.2
Mokan, M.3
Veneman, T.4
Pangburn, T.5
Reilly, J.6
Gerich, J.7
-
16
-
-
77957768686
-
AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner
-
Lee, J. M., Seo, W. Y., Song, K. H., Chanda, D., Kim, Y. D., Kim, D. K., Lee, M. W., Ryu, D., Kim, Y. H., Noh, J. R., Lee, C. H., Chiang, J. Y., Koo, S. H., and Choi, H. S. (2010) AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner. J. Biol. Chem. 285, 32182-32191
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 32182-32191
-
-
Lee, J.M.1
Seo, W.Y.2
Song, K.H.3
Chanda, D.4
Kim, Y.D.5
Kim, D.K.6
Lee, M.W.7
Ryu, D.8
Kim, Y.H.9
Noh, J.R.10
Lee, C.H.11
Chiang, J.Y.12
Koo, S.H.13
Choi, H.S.14
-
17
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., and Kahn, C. R. (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6, 87-97
-
(2000)
Mol. Cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
Previs, S.F.4
Shulman, G.I.5
Magnuson, M.A.6
Kahn, C.R.7
-
18
-
-
3543029821
-
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
-
DOI 10.1074/jbc.M313478200
-
Samuel, V. T., Liu, Z. X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., and Shulman, G. I. (2004) Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J. Biol. Chem. 279, 32345-32353 (Pubitemid 39014687)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.31
, pp. 32345-32353
-
-
Samuel, V.T.1
Liu, Z.-X.2
Qu, X.3
Elder, B.D.4
Bilz, S.5
Befroy, D.6
Romanelli, A.J.7
Shulman, G.I.8
-
19
-
-
0031786715
-
Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice
-
DOI 10.1530/eje.0.1390461
-
Ahren, B., and Scheurink, A. J. (1998) Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice. Eur. J. Endocrinol. 139, 461-467 (Pubitemid 28494094)
-
(1998)
European Journal of Endocrinology
, vol.139
, Issue.4
, pp. 461-467
-
-
Ahren, B.1
Scheurink, A.J.W.2
-
20
-
-
0024385671
-
Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir
-
Lopaschuk, G. D., McNeil, G. F., and McVeigh, J. J. (1989) Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir. Mol. Cell. Biochem. 88, 175-179 (Pubitemid 19203214)
-
(1989)
Molecular and Cellular Biochemistry
, vol.88
, Issue.1-2
, pp. 175-179
-
-
Lopschuk, G.D.1
McNeil, G.F.2
McVeigh, J.J.3
-
21
-
-
0025727793
-
Mechanisms of the glucose lowering effect of a carnitine palmitoyl transferase inhibitor in normal and diabetic rats
-
Martin, C., Odeon, M., Cohen, R., and Beylot, M. (1991) Mechanisms of the glucose lowering effect of a carnitine palmitoyl transferase inhibitor in normal and diabetic rats. Metabolism 40, 420-427
-
(1991)
Metabolism
, vol.40
, pp. 420-427
-
-
Martin, C.1
Odeon, M.2
Cohen, R.3
Beylot, M.4
-
22
-
-
65549136655
-
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
-
He, L., Sabet, A., Djedjos, S., Miller, R., Sun, X., Hussain, M. A., Radovick, S., and Wondisford, F. E. (2009) Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell 137, 635-646
-
(2009)
Cell
, vol.137
, pp. 635-646
-
-
He, L.1
Sabet, A.2
Djedjos, S.3
Miller, R.4
Sun, X.5
Hussain, M.A.6
Radovick, S.7
Wondisford, F.E.8
-
23
-
-
34547946930
-
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance
-
DOI 10.1074/jbc.M704213200
-
Choi, C. S., Savage, D. B., Kulkarni, A., Yu, X. X., Liu, Z. X., Morino, K., Kim, S., Distefano, A., Samuel, V. T., Neschen, S., Zhang, D., Wang, A., Zhang, X. M., Kahn, M., Cline, G. W., Pandey, S. K., Geisler, J. G., Bhanot, S., Monia, B. P., and Shulman, G. I. (2007) Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. 282, 22678-22688 (Pubitemid 47267336)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.31
, pp. 22678-22688
-
-
Cheol, S.C.1
Savage, D.B.2
Kulkarni, A.3
Xing, X.Y.4
Liu, Z.-X.5
Morino, K.6
Kim, S.7
Distefano, A.8
Samuel, V.T.9
Neschen, S.10
Zhang, D.11
Wang, A.12
Zhang, X.-M.13
Kahn, M.14
Cline, G.W.15
Pandey, S.K.16
Geisler, J.G.17
Bhanot, S.18
Monia, B.P.19
Shulman, G.I.20
more..
-
24
-
-
34347235098
-
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver
-
DOI 10.1016/j.cmet.2007.05.005, PII S1550413107001325
-
Monetti, M., Levin, M. C., Watt, M. J., Sajan, M. P., Marmor, S., Hubbard, B. K., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., Sr., Hevener, A. L., and Farese, R. V., Jr. (2007) Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6, 69-78 (Pubitemid 46995777)
-
(2007)
Cell Metabolism
, vol.6
, Issue.1
, pp. 69-78
-
-
Monetti, M.1
Levin, M.C.2
Watt, M.J.3
Sajan, M.P.4
Marmor, S.5
Hubbard, B.K.6
Stevens, R.D.7
Bain, J.R.8
Newgard, C.B.9
Farese Sr., R.V.10
Hevener, A.L.11
Farese Jr., R.V.12
-
25
-
-
65549151428
-
The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans
-
Kantartzis, K., Machicao, F., Machann, J., Schick, F., Fritsche, A., Haring, H. U., and Stefan, N. (2009) The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans. Clin. Sci. (Lond.) 116, 531-537
-
(2009)
Clin. Sci. (Lond.)
, vol.116
, pp. 531-537
-
-
Kantartzis, K.1
Machicao, F.2
Machann, J.3
Schick, F.4
Fritsche, A.5
Haring, H.U.6
Stefan, N.7
-
26
-
-
22544480378
-
"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis
-
DOI 10.1016/j.cmet.2005.04.002, PII S1550413105001105
-
Chakravarthy, M. V., Pan, Z., Zhu, Y., Tordjman, K., Schneider, J. G., Coleman, T., Turk, J., and Semenkovich, C. F. (2005) "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab. 1, 309-322 (Pubitemid 43977168)
-
(2005)
Cell Metabolism
, vol.1
, Issue.5
, pp. 309-322
-
-
Chakravarthy, M.V.1
Pan, Z.2
Zhu, Y.3
Tordjman, K.4
Schneider, J.G.5
Coleman, T.6
Turk, J.7
Semenkovich, C.F.8
-
27
-
-
78149346457
-
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
-
Brown, J. M., Betters, J. L., Lord, C., Ma, Y., Han, X., Yang, K., Alger, H. M., Melchior, J., Sawyer, J., Shah, R., Wilson, M. D., Liu, X., Graham, M. J., Lee, R., Crooke, R., Shulman, G. I., Xue, B., Shi, H., and Yu, L. (2010) CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. J. Lipid Res. 51, 3306-3315
-
(2010)
J. Lipid Res.
, vol.51
, pp. 3306-3315
-
-
Brown, J.M.1
Betters, J.L.2
Lord, C.3
Ma, Y.4
Han, X.5
Yang, K.6
Alger, H.M.7
Melchior, J.8
Sawyer, J.9
Shah, R.10
Wilson, M.D.11
Liu, X.12
Graham, M.J.13
Lee, R.14
Crooke, R.15
Shulman, G.I.16
Xue, B.17
Shi, H.18
Yu, L.19
-
28
-
-
53149101726
-
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice
-
Minehira, K., Young, S. G., Villanueva, C. J., Yetukuri, L., Oresic, M., Hellerstein, M. K., Farese, R. V., Horton, J. D., Preitner, F., Thorens, B., and Tappy, L. (2008) Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J. Lipid Res. 49, 2038-2044
-
(2008)
J. Lipid Res.
, vol.49
, pp. 2038-2044
-
-
Minehira, K.1
Young, S.G.2
Villanueva, C.J.3
Yetukuri, L.4
Oresic, M.5
Hellerstein, M.K.6
Farese, R.V.7
Horton, J.D.8
Preitner, F.9
Thorens, B.10
Tappy, L.11
-
29
-
-
77950543816
-
Diacylglycerol-mediated insulin resistance
-
Erion, D. M., and Shulman, G. I. (2010) Diacylglycerol-mediated insulin resistance. Nat. Med. 16, 400-402
-
(2010)
Nat. Med.
, vol.16
, pp. 400-402
-
-
Erion, D.M.1
Shulman, G.I.2
-
30
-
-
84863115883
-
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
-
Zhang, C. B., Wendel, A. A., Keogh, M. R., Harris, T. E., Chen, J., and Coleman, R. A. (2012) Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proc. Natl. Acad. Sci. U. S. A. 109, 1667-1672
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 1667-1672
-
-
Zhang, C.B.1
Wendel, A.A.2
Keogh, M.R.3
Harris, T.E.4
Chen, J.5
Coleman, R.A.6
-
31
-
-
50549202600
-
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
-
Randle, P. J., Garland, P. B., Hales, C. N., and Newsholme, E. A. (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1, 785-789
-
(1963)
Lancet
, vol.1
, pp. 785-789
-
-
Randle, P.J.1
Garland, P.B.2
Hales, C.N.3
Newsholme, E.A.4
-
33
-
-
0025991923
-
Inhibition by etomoxir of carnitine palmitoyltransferase i reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus
-
Ratheiser, K., Schneeweiss, B., Waldhausl, W., Fasching, P., Korn, A., Nowotny, P., Rohac, M., and Wolf, H. P. (1991) Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus. Metabolism 40, 1185-1190
-
(1991)
Metabolism
, vol.40
, pp. 1185-1190
-
-
Ratheiser, K.1
Schneeweiss, B.2
Waldhausl, W.3
Fasching, P.4
Korn, A.5
Nowotny, P.6
Rohac, M.7
Wolf, H.P.8
-
34
-
-
79551605843
-
Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis
-
Conti, R., Mannucci, E., Pessotto, P., Tassoni, E., Carminati, P., Giannessi, F., and Arduini, A. (2011) Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis. Diabetes 60, 644-651
-
(2011)
Diabetes
, vol.60
, pp. 644-651
-
-
Conti, R.1
Mannucci, E.2
Pessotto, P.3
Tassoni, E.4
Carminati, P.5
Giannessi, F.6
Arduini, A.7
-
35
-
-
0030699261
-
Effects of the carnitine-acyltransferase inhibitor etomoxir on insulin sensitivity, energy expenditure and substrate oxidation in NIDDM
-
Hubinger, A., Knode, O., Susanto, F., Reinauer, H., and Gries, F. A. (1997) Effects of the carnitine-acyltransferase inhibitor etomoxir on insulin sensitivity, energy expenditure and substrate oxidation in NIDDM. Horm. Metab. Res. 29, 436-439 (Pubitemid 27454111)
-
(1997)
Hormone and Metabolic Research
, vol.29
, Issue.9
, pp. 436-439
-
-
Hubinger, A.1
Knode, O.2
Susanto, F.3
Reinauer, H.4
Cries, F.A.5
-
36
-
-
0029797027
-
Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver
-
Ferre, T., Riu, E., Bosch, F., and Valera, A. (1996) Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver. FASEB J. 10, 1213-1218 (Pubitemid 26276964)
-
(1996)
FASEB Journal
, vol.10
, Issue.10
, pp. 1213-1218
-
-
Ferre, T.1
Riu, E.2
Bosch, F.3
Valera, A.4
-
37
-
-
0030884675
-
Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism
-
DOI 10.1074/jbc.272.36.22570
-
Niswender, K. D., Shiota, M., Postic, C., Cherrington, A. D., and Magnuson, M. A. (1997) Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J. Biol. Chem. 272, 22570-22575 (Pubitemid 27386069)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.36
, pp. 22570-22575
-
-
Niswender, K.D.1
Shiota, M.2
Postic, C.3
Cherrington, A.D.4
Magnuson, M.A.5
-
38
-
-
0031022573
-
Expression of human hepatic glucokinase in transgenic mice liver results in decreased glucose levels and reduced body weight
-
Hariharan, N., Farrelly, D., Hagan, D., Hillyer, D., Arbeeny, C., Sabrah, T., Treloar, A., Brown, K., Kalinowski, S., and Mookhtiar, K. (1997) Expression of human hepatic glucokinase in transgenic mice liver results in decreased glucose levels and reduced body weight. Diabetes 46, 11-16 (Pubitemid 27009942)
-
(1997)
Diabetes
, vol.46
, Issue.1
, pp. 11-16
-
-
Hariharan, N.1
Farrelly, D.2
Hagan, D.3
Hillyer, D.4
Arbeeny, C.5
Sabrah, T.6
Treloar, A.7
Brown, K.8
Kalinowski, S.9
Mookhtiar, K.10
-
39
-
-
79959308013
-
Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice
-
Winzell, M. S., Coghlan, M., Leighton, B., Frangioudakis, G., Smith, D. M., Storlien, L. H., and Ahren, B. (2011) Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice. Eur. J. Pharmacol. 663, 80-86
-
(2011)
Eur. J. Pharmacol.
, vol.663
, pp. 80-86
-
-
Winzell, M.S.1
Coghlan, M.2
Leighton, B.3
Frangioudakis, G.4
Smith, D.M.5
Storlien, L.H.6
Ahren, B.7
-
40
-
-
78651399025
-
Peroxisome proliferator-activated receptor alpha is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db mice
-
Im, S. S., Kim, M. Y., Kwon, S. K., Kim, T. H., Bae, J. S., Kim, H., Kim, K. S., Oh, G. T., and Ahn, Y. H. (2011) Peroxisome proliferator-activated receptor alpha is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db mice. J. Biol. Chem. 286, 1157-1164
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 1157-1164
-
-
Im, S.S.1
Kim, M.Y.2
Kwon, S.K.3
Kim, T.H.4
Bae, J.S.5
Kim, H.6
Kim, K.S.7
Oh, G.T.8
Ahn, Y.H.9
-
41
-
-
0042967650
-
Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice
-
DOI 10.1038/nm898
-
Bernal-Mizrachi, C., Weng, S., Feng, C., Finck, B. N., Knutsen, R. H., Leone, T. C., Coleman, T. Y., Mecham, R. P., Kelly, D. P., and Semenkovich, C. F. (2003) Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat. Med. 9, 1069-1075 (Pubitemid 37021788)
-
(2003)
Nature Medicine
, vol.9
, Issue.8
, pp. 1069-1075
-
-
Bernal-Mizrachi, C.1
Weng, S.2
Feng, C.3
Finck, B.N.4
Knutsen, R.H.5
Leone, T.C.6
Coleman, T.7
Mecham, R.P.8
Kelly, D.P.9
Semenkovich, C.F.10
-
42
-
-
2442701392
-
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
-
DOI 10.1038/nm1044
-
Koo, S. H., Satoh, H., Herzig, S., Lee, C. H., Hedrick, S., Kulkarni, R., Evans, R. M., Olefsky, J., and Montminy, M. (2004) PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat. Med. 10, 530-534 (Pubitemid 38667913)
-
(2004)
Nature Medicine
, vol.10
, Issue.5
, pp. 530-534
-
-
Koo, S.-H.1
Satoh, H.2
Herzig, S.3
Lee, C.-H.4
Hedrick, S.5
Kulkarni, R.6
Evans, R.M.7
Olefsky, J.8
Montminy, M.9
-
43
-
-
81755172437
-
Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor alpha
-
Fan, Y., Guo, Y., Hamblin, M., Chang, L., Zhang, J., and Chen, Y. E. (2011) Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 286, 40584-40594
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 40584-40594
-
-
Fan, Y.1
Guo, Y.2
Hamblin, M.3
Chang, L.4
Zhang, J.5
Chen, Y.E.6
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