A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet

Diabetes

Volumn 55, Issue 7, 2006, Pages 2015-2020

  Raubenheimer, Peter J ^a   Nyirenda, Moffat J ^a   Walker, Brian R ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Acsl, acyl CoA synthetase long chain; Agpat, lysophosphatidic acid acyltransferase; AUCgl, area under the glucose curve; CDD, choline deficient diet; Cpt1a, carnitine palmitoyl transferase 1a; DAG, diacylglycerol; Dgat, DAG o acyltransferase

Indexed keywords

CHOLINE; FATTY ACID; INSULIN; LIPID; MESSENGER RNA; TRIACYLGLYCEROL; PHOSPHATIDYLCHOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FAT BODY; FAT INTAKE; FATTY ACID OXIDATION; FATTY LIVER; GLUCOSE INTOLERANCE; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPID DIET; LIPID STORAGE; LIPOGENESIS; LOW FAT DIET; MALE; MOUSE; NONHUMAN; NUTRITIONAL ASSESSMENT; OBESITY; PRIORITY JOURNAL; WEIGHT GAIN; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CALORIC INTAKE; DISEASE MODEL; ENZYMOLOGY; GENETICS; GLUCOSE BLOOD LEVEL; KINETICS; LIVER; METABOLISM; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; VITAMIN DEFICIENCY;

ANIMALS; BLOOD GLUCOSE; CHOLINE DEFICIENCY; DIETARY FATS; DISEASE MODELS, ANIMAL; ENERGY INTAKE; FATTY LIVER; GLUCOSE INTOLERANCE; KINETICS; LIVER; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; PHOSPHATIDYLCHOLINES; RNA, MESSENGER; WEIGHT GAIN;

EID: 33747079056     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0097     Document Type: Article

References (40)

1. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G, Melchionda N: Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50:1844-1850, 2001
2. Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN: Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 120:1183-1192, 2001
3. Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, Karim R, Lin R, Samarasinghe D, Liddle C: NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 35:373-379, 2002
4. Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depetris N, Cassader M, David E, Cavallo-Perin P, Rizzetto M: Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 35:367-372, 2002
5. Ryysy L, Hakkinen AM, Goto T, Vehkavaara S, Westerbacka J, Halavaara J, Yki-Jarvinen H: Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49:749-758, 2000
6. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, Halavaara J, Yki-Jarvinen H: Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87:3023-3028, 2002
7. Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman ML, Vinson C: Life without white fat: a transgenic mouse. Genes Dev 12:3168-3181, 1998
8. Carr A, Samaras K, Chisholm DJ, Cooper DA: Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. Lancet 351:1881-1883, 1998
9. Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS: Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 12:3182-3194, 1998
10. Reitman ML, Arioglu E, Gavrilova O, Taylor SI: Lipoatrophy revisited. Trends Endocrinol Metab 11:410-416, 2000
11. Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI: Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279:32345-32353, 2004
12. Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH: Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40:1397-1403, 1991
13. Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, Lutz EP, Kako Y, Velez-Carrasco W, Goldberg IJ, Breslow JL, Shulman GI: Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A 98:7522-7527, 2001
14. Kim SP, Ellmerer M, Van Citters GW, Bergman RN: Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog. Diabetes 52:2453-2460, 2003
15. Marchesini G, Brizi M, Morselli-Labate AM, Bianchi G, Bugianesi E, McCullough AJ, Forlani G, Melchionda N: Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 107:450-455, 1999
16. Yao ZM, Vance DE: The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 263:2998-3004, 1988
17. Rinella ME, Green RM: The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 40:47-51, 2004
18. Kirsch R, Clarkson V, Shephard EG, Marais DA, Jaffer MA, Woodburne VE, Kirsch RE, Hall PL: Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies. J Gastroenterol Hepatol 18:1272-1282, 2003
19. Schattenberg JM, Wang Y, Singh R, Rigoli RM, Czaja MJ: Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. J Biol Chem 280:9887-9894, 2005
20. Kulinski A, Vance DE, Vance JE: A choline-deficient diet in mice inhibits neither the CDP-choline pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion. J Biol Chem 279:23916-23924, 2004
21. Hartroft, WS: The sequence of pathologic events in the development of experimental fatty liver and cirrhosis. Ann N Y Acad Sci 57:633-645, 1954
22. Rushmore TH, Ghazarian DM, Subrahmanyan V, Farber E, Ghoshal AK: Probable free radical effects on rat liver nuclei during early hepatocarcinogenesis with a choline-devoid low methionine diet. Cancer Res 47:6731-6740, 1987
23. Yao ZM, Jamil H, Vance DE: Choline deficiency causes translocation of CTP:phosphocholine cytidylyltransferase from cytosol to endoplasmic reticulum in rat liver. J Biol Chem 265:4326-4331, 1990
24. Cui Z, Vance DE: Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats. J Biol Chem 271:2839-2843, 1996
25. Coleman RA, Lewin TM, Muoio DM: Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. Annu Rev Nutr 20:77-103, 2000
26. Lewin TM, Kim JH, Granger DA, Vance JE, Coleman RA: Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. J Biol Chem 276:24674-24679, 2001
27. Coleman RA, Lee DP: Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res 43:134-176, 2004
28. Lewin TM, Wang S, Nagle CA, Van Horn CG, Coleman RA: Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes. Am J Physiol Endocrinol Metab 288: E835-E844, 2005
29. Yamazaki T, Sasaki E, Kakinuma C, Yano T, Miura S, Ezaki O: Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1. J Biol Chem 280:21506-21514, 2005
30. Shimomura I, Shimano H, Korn BS, Bashmakov Y, Horton JD: Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. J Biol Chem 273:35299-35306, 1998
31. Ericsson J, Jackson SM, Kim JB, Spiegelman BM, Edwards PA: Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. J Biol Chem 272:7298-7305, 1997
32. Kast HR, Nguyen CM, Anisfeld AM, Ericsson J, Edwards PA: CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene. J Lipid Res 42:1266-1272, 2001
33. Lagace TA, Storey MK, Ridgway ND: Regulation of phosphatidylcholine metabolism in Chinese hamster ovary cells by the sterol regulatory element-binding protein (SREBP)/SREBP cleavage-activating protein pathway. J Biol Chem 275:14367-14374, 2000
34. Stals HK, Mannaerts GP, Declercq PE: Factors influencing triacylglycerol synthesis in permeabilized rat hepatocytes. Biochem J 283:719-725, 1992
35. Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103:253-259, 1999
36. Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI: Free fatty acid-induced insulin resistance is associated with activation of protein kinase C and alterations in the insulin signaling cascade. Diabetes 48:1270-1274, 1999
37. Listenberger LL, Han X, Lewis SE, Cases S, Farese RV Jr, Ory DS, Schaffer JE: Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A 100:3077-3082, 2003
38. Montell E, Turini M, Marotta M, Roberts M, Noe V, Ciudad CJ, Mace K, Gomez-Foix AM: DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells. Am J Physiol Endocrinol Metab 280:E229-E237, 2001
39. Lan H, Rabaglia ME, Stoehr JP, Nadler ST, Schueler KL, Zou F, Yandell BS, Attie AD: Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes 52:688-700, 2003
40. Goshal AK, Farber E: Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: a new perspective. Lab Invest 68:255-260, 1993