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Volumn 21, Issue 4, 2000, Pages 823-826

Peroxisome proliferator-activated receptor α is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; RECEPTOR SUBTYPE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0034052579     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.4.823     Document Type: Article
Times cited : (114)

References (23)
  • 1
    • 0342528190 scopus 로고
    • A fatty acyl CoA oxidizing system in rat liver peroxisomes: Enhancement by clofibrate, a hypolipidemic drug
    • Lazarow, P.B. and DeDuve, C. (1976) A fatty acyl CoA oxidizing system in rat liver peroxisomes: enhancement by clofibrate, a hypolipidemic drug. Proc. Natl Acad. Sci. USA, 73, 2043-2046.
    • (1976) Proc. Natl Acad. Sci. USA , vol.73 , pp. 2043-2046
    • Lazarow, P.B.1    DeDuve, C.2
  • 2
    • 0021348339 scopus 로고
    • Induction of hepatic peroxisome proliferation in nonrodent species, including primates
    • Reddy, J.K., Lalwani, N.D., Qureshi, S.A., Reddy, M.K. and Moehle, C.M. (1984) Induction of hepatic peroxisome proliferation in nonrodent species, including primates. Am. J. Pathol., 114, 171-183.
    • (1984) Am. J. Pathol. , vol.114 , pp. 171-183
    • Reddy, J.K.1    Lalwani, N.D.2    Qureshi, S.A.3    Reddy, M.K.4    Moehle, C.M.5
  • 3
    • 0031418657 scopus 로고    scopus 로고
    • Role of PPARα in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator WY-14,643
    • Peters, J.M., Cattley, R.C. and Gonzalez, F.J. (1997) Role of PPARα in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator WY-14,643. Carcinogenesis, 18, 2029-2033.
    • (1997) Carcinogenesis , vol.18 , pp. 2029-2033
    • Peters, J.M.1    Cattley, R.C.2    Gonzalez, F.J.3
  • 4
    • 0345036072 scopus 로고
    • DNA damage related to increased hydrogen peroxide generation by hypolipidemic drug-induced liver peroxisomes
    • Fahl, W.E., Lalwani, N.D., Watanabe, T., Goel, S.K. and Reddy, J.K. (1984) DNA damage related to increased hydrogen peroxide generation by hypolipidemic drug-induced liver peroxisomes. Proc. Natl Acad. Sci. USA, 81, 7827-7830.
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 7827-7830
    • Fahl, W.E.1    Lalwani, N.D.2    Watanabe, T.3    Goel, S.K.4    Reddy, J.K.5
  • 5
    • 0024241608 scopus 로고
    • Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]-acetic acid (Wy-14,643) in rats
    • Marsman, D.S., Cattley, R.C., Conway, J.G. and Popp, J.A. (1988) Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]-acetic acid (Wy-14,643) in rats. Cancer Res., 48, 6739-6744.
    • (1988) Cancer Res. , vol.48 , pp. 6739-6744
    • Marsman, D.S.1    Cattley, R.C.2    Conway, J.G.3    Popp, J.A.4
  • 6
    • 0031781381 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver
    • Peters, J.M., Aoyama, T., Cattley, R.C., Nobumitsu, U., Hashimoto, T. and Gonzalez, F.J. (1998) Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. Carcinogenesis, 19, 1989-1994.
    • (1998) Carcinogenesis , vol.19 , pp. 1989-1994
    • Peters, J.M.1    Aoyama, T.2    Cattley, R.C.3    Nobumitsu, U.4    Hashimoto, T.5    Gonzalez, F.J.6
  • 7
    • 0025220542 scopus 로고
    • Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver
    • Gerbracht, U., Bursch, W., Kraus, P., Putz, B., Reinacher, M., Timmermann-Trosiener, J. and Schulte-Hermann, R. (1990) Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver. Carcinogenesis, 11, 617-624.
    • (1990) Carcinogenesis , vol.11 , pp. 617-624
    • Gerbracht, U.1    Bursch, W.2    Kraus, P.3    Putz, B.4    Reinacher, M.5    Timmermann-Trosiener, J.6    Schulte-Hermann, R.7
  • 8
    • 0028208243 scopus 로고
    • Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin
    • Bayly, A.C., Roberts, R.A. and Dive, C. (1994) Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin. J. Cell Biol., 125, 197-203.
    • (1994) J. Cell Biol. , vol.125 , pp. 197-203
    • Bayly, A.C.1    Roberts, R.A.2    Dive, C.3
  • 9
    • 0026631269 scopus 로고
    • Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell replication for the hepatocarcinogens WY-14,643 and clofibric acid
    • Marsman, D.S., Goldsworthy, T.L. and Popp, J.A. (1992) Contrasting hepatocytic peroxisome proliferation, lipofuscin accumulation and cell replication for the hepatocarcinogens WY-14,643 and clofibric acid. Carcinogenesis, 15, 1011-1017.
    • (1992) Carcinogenesis , vol.15 , pp. 1011-1017
    • Marsman, D.S.1    Goldsworthy, T.L.2    Popp, J.A.3
  • 10
    • 0032545018 scopus 로고    scopus 로고
    • Mechanism of action of the nongenotoxic peroxisome proliferators: Role of the peroxisome proliferator-activated receptor alpha
    • Gonzalez, F.J., Peters, J.M. and Cattley, R.C. (1998) Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activated receptor alpha. J. Natl Cancer Inst., 90, 1702-1709.
    • (1998) J. Natl Cancer Inst. , vol.90 , pp. 1702-1709
    • Gonzalez, F.J.1    Peters, J.M.2    Cattley, R.C.3
  • 12
    • 0031419250 scopus 로고    scopus 로고
    • Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators
    • Rose, M.L., Germolec, D.R., Schoonhoven, R. and Thurman, R.G. (1997) Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators. Carcinogenesis, 18, 1453-1456.
    • (1997) Carcinogenesis , vol.18 , pp. 1453-1456
    • Rose, M.L.1    Germolec, D.R.2    Schoonhoven, R.3    Thurman, R.G.4
  • 13
    • 0030881268 scopus 로고    scopus 로고
    • Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643
    • Rose, M.L., Germolec, D.R., Arteel, G.E., Schoonhoven, R. and Thurman, R.G. (1997) Dietary glycine prevents increases in hepatocyte proliferation caused by the peroxisome proliferator WY-14,643. Chem. Res. Toxicol., 10, 1198-1204.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 1198-1204
    • Rose, M.L.1    Germolec, D.R.2    Arteel, G.E.3    Schoonhoven, R.4    Thurman, R.G.5
  • 14
    • 0031417341 scopus 로고    scopus 로고
    • Antibodies to tumor necrosis factor a prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643
    • Bojes, H.K., Germolec, D.R., Simeonova, P., Bruccoleri, A., Luster, M.I. and Thurman, R.G. (1997) Antibodies to tumor necrosis factor a prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY-14,643. Carcinogenesis, 18, 669-674.
    • (1997) Carcinogenesis , vol.18 , pp. 669-674
    • Bojes, H.K.1    Germolec, D.R.2    Simeonova, P.3    Bruccoleri, A.4    Luster, M.I.5    Thurman, R.G.6
  • 15
    • 0031878489 scopus 로고    scopus 로고
    • WY-14,643 rapidly activates nuclear factor KB in Kupffer cells before hepatocytes
    • Rusyn, I., Tsukamoto, H. and Thurman, R.G. (1998) WY-14,643 rapidly activates nuclear factor KB in Kupffer cells before hepatocytes. Carcinogenesis, 19, 1217-1222.
    • (1998) Carcinogenesis , vol.19 , pp. 1217-1222
    • Rusyn, I.1    Tsukamoto, H.2    Thurman, R.G.3
  • 17
    • 0022416353 scopus 로고
    • Preparation of pure hepatocytes and reticuloendothelial cells in high yield from a single rat liver by means of Percoll centrifugation and selective adherence
    • Smedsrod, B. and Pertoft, H. (1985) Preparation of pure hepatocytes and reticuloendothelial cells in high yield from a single rat liver by means of Percoll centrifugation and selective adherence. J. Leukoc. Biol., 38, 213-230.
    • (1985) J. Leukoc. Biol. , vol.38 , pp. 213-230
    • Smedsrod, B.1    Pertoft, H.2
  • 18
    • 0023259982 scopus 로고
    • Identification and characterization of liver nonparenchymal cells by flow cytometry
    • Doolittle, M., Bohman, R., Durstenfeld, A. and Cascarano, J. (1987) Identification and characterization of liver nonparenchymal cells by flow cytometry. Hepatology, 7, 696-703.
    • (1987) Hepatology , vol.7 , pp. 696-703
    • Doolittle, M.1    Bohman, R.2    Durstenfeld, A.3    Cascarano, J.4
  • 20
    • 0028003839 scopus 로고
    • Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids
    • Lemberger, T., Staels, B., Saladin, R., Desvergne, B., Auwerx, J. and Wahli, W. (1994) Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. J. Biol. Chem., 269, 24527-24530.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24527-24530
    • Lemberger, T.1    Staels, B.2    Saladin, R.3    Desvergne, B.4    Auwerx, J.5    Wahli, W.6
  • 21
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J. and Glass, C.K. (1998) The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature, 391, 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 22
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee, S.S., Pineau, T., Drago, J., Lee, E.J., Owens, J.W., Kroetz, D.L., Fernandez-Salguero, P.M., Westphal, H. and Gonzalez, F.J. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell Biol., 15, 3012-3022.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Drago, J.3    Lee, E.J.4    Owens, J.W.5    Kroetz, D.L.6    Fernandez-Salguero, P.M.7    Westphal, H.8    Gonzalez, F.J.9
  • 23
    • 0022470691 scopus 로고
    • Differential inhibition of prostaglandin and superoxide production by dexamethasome in primary cultures of rat Kupffer cells
    • Dieter, P., Schulze-Specking, A. and Decker, K. (1986) Differential inhibition of prostaglandin and superoxide production by dexamethasome in primary cultures of rat Kupffer cells. Eur. J. Biochem., 159, 451-457.
    • (1986) Eur. J. Biochem. , vol.159 , pp. 451-457
    • Dieter, P.1    Schulze-Specking, A.2    Decker, K.3


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