Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 28544-28555

  Mitsutake, Susumu ^a   Zama, Kota ^a   Yokota, Hazuki ^a   Yoshida, Tetsuya ^b   Tanaka, Miki ^b   Mitsui, Masaru ^b   Ikawa, Masahito ^c   Okabe, Masaru ^c   Tanaka, Yoshikazu ^b   Yamashita, Tadashi ^a   Takemoto, Hiroshi ^b   Okazaki, Toshiro ^d   Watanabe, Ken ^e   Igarashi, Yasuyuki ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d TOTTORI UNIVERSITY   (Japan)

^e NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL MEMBRANES; DROP FORMATION; FATTY ACIDS; MAMMALS; NUTRITION; PHOSPHOLIPIDS;

CONFORMATIONAL CHANGE; DYNAMIC MODIFICATIONS; DYNAMIC REGULATION; GLUCOSE HOMEOSTASIS; INSULIN RESISTANCE; PHYSIOLOGICAL FUNCTIONS; SCAFFOLDING PROTEINS; SPHINGOMYELIN SYNTHASES;

SCAFFOLDS (BIOLOGY);

CAVEOLIN 1; CD36 ANTIGEN; CERAMIDE; FAT DROPLET; FATTY ACID TRANSPORTER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMALL INTERFERING RNA; SPHINGOMYELIN; SPHINGOMYELIN SYNTHASE 2; SYNTHETASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAVEOLA; CELL STRAIN HEPG2; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FATTY ACID TRANSPORT; FATTY LIVER; HUMAN; HUMAN CELL; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL;

MUS;

EID: 80051495481     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.255646     Document Type: Article

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