Acyl coenzyme A: Cholesterol acyltransferase types 1 and 2: Structure and function in atherosclerosis

Current Opinion in Lipidology

Volumn 12, Issue 2, 2001, Pages 121-127

  Rudel, Lawrence L ^a   Lee, Richard G ^a   Cockman, Terri L ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; CHOLESTEROL ACYLTRANSFERASE;

ATHEROSCLEROSIS; CHOLESTEROL METABOLISM; ENZYME ACTIVITY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARTERIOSCLEROSIS; CELL MEMBRANE; HUMANS; ISOENZYMES; MICE; MICE, KNOCKOUT; MUTAGENESIS; STEROL O-ACYLTRANSFERASE; TRANSFECTION;

PRIMATES;

EID: 0035081589     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200104000-00005     Document Type: Review

References (26)

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2. The relationship between plasma and tissue lipids in human atherosclerosis
3. Molecular cloning and functional expression of human acyl-coenzyme A: Cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells
4. Acyl CoA: Cholesterol acyltransferase genes and knockout mice
5. Identification of a form of acyl-CoA : Cholesterol acyltransferase specific to liver and intestine in nonhuman primates
6. Identification of a gene encoding an acyl CoA: Diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
7. ACAT-2, a second mammalian acyl-CoA: Cholesterol acyltransferase. Its cloning, expression, and characterization
8. Characterization of two human genes encoding acyl coenzyme A: Cholesterol acyltransferase-related enzymes
9. Disruption of the acyl-CoA: Cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals
10. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA: Cholesterol acyltransferase 1
11. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia
12. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
13. Complementation of mutation in acyl-CoA: Cholesterol acyltransferase (ACAT) fails to restore sterol regulation in ACAT-defective sterol-resistant hamster cells
14. ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane
15. Localization of human acyl-coenzyme A: Cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues
16. Role of acyl-coenzyme A: Cholesterol acyltransferase-1 in the control of hepatic VLDL secretion and LDL receptor expression in the mouse and hamster
17. ApoB100 secretion from HepG2 cells is decreased by the ACAT inhibitor Cl-1011 - An effect associated with enhanced intracellular degradation of ApoB
18. Human acyl-CoA: Cholesterol acyltransferase-1 is a homotetrameric enzyme in intact cells and in vitro
19. Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
20. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine
21. The citrus flavonoids, naringenin and hesperetin, inhibit apoB secretion from HepG2 cells via reduced expression of ACAT2 and MTP
22. Distinct intracellular locations of ACAT-1 and ACAT-2 in differentiated Caco-2 cells
23. Enrichment of acyl coenzyme A: Cholesterol o-acyltransferase near trans-Golgi network and endocytic recycling compartment
24. Sterol esterification in yeast: A two-gene process
25. Human acyl-CoA: Cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains