Update on perilipin polymorphisms and obesity

Nutrition Reviews

Volumn 70, Issue 10, 2012, Pages 611-621

  Smith, Caren E ^a   Ordovás, José M ^a,b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Epidemiology; Genetics; Nutrients; Obesity

Indexed keywords

MICRORNA; PERILIPIN; PERILIPIN 1; PERILIPIN 4; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; BINDING SITE; BODY WEIGHT; ENERGY METABOLISM; EXPERIMENTAL ANIMAL; FITNESS; GENE; GENE EXPRESSION; GENETIC REGULATION; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; GLUCOSE METABOLISM; HUMAN; LIPID METABOLISM; LIPOLYSIS; NONHUMAN; NUTRITION; OBESITY; PHENOTYPE; PLIN1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOCYTES; ANIMALS; CARRIER PROTEINS; DIET; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; LIPID METABOLISM; LIPOLYSIS; OBESITY; PHOSPHOPROTEINS; POLYMORPHISM, GENETIC;

ANIMALIA;

EID: 84867155451     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2012.00515.x     Document Type: Article

References (67)

1. Finucane MM, Stevens GA, Cowan MJ, etal. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet. 2011;377:557-567.
2. Danaei G, Finucane MM, Lu Y, etal. Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose). National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011;378:31-40.
3. Wardle J, Carnell S, Haworth CM, etal. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr. 2008;87:398-404.
4. Thorleifsson G, Walters GB, Gudbjartsson DF, etal. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009;41:18-24.
5. Willer CJ, Speliotes EK, Loos RJ, etal. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25-34.
6. Speliotes EK, Willer CJ, Berndt SI, etal. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937-948.
7. Egan JJ, Greenberg AS, Chang MK, etal. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and β-adrenergic stimulation. J Biol Chem. 1990;265:18769-18775.
8. Greenberg AS, Egan JJ, Wek SA, etal. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem. 1991;266:11341-11346.
9. Miura S, Gan JW, Brzostowski J, etal. Functional conservation for lipid storage droplet association among erilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J Biol Chem. 2002;277:32253-32257.
10. Kimmel AR, Brasaemle DL, McAndrews-Hill M, etal. Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res. 2010;51:468-471.
11. Richardson K, Louie-Gao Q, Arnett DK, etal. The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site. PLoS ONE. 2011;6:e17944.
12. Brasaemle DL, Rubin B, Harten I, etal. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J Biol Chem. 2000;275:38486-38493.
13. Miyoshi H, Souza SC, Zhang HH, etal. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem. 2006;281:15837-15844.
14. Zimmermann R, Strauss JG, Haemmerle G, etal. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science. 2004;306:1383-1386.
15. Subramanian V, Rothenberg A, Gomez C, etal. Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J Biol Chem. 2004;279:42062-42071.
16. Granneman JG, Moore HP. Location, location: protein trafficking and lipolysis in adipocytes. Trends Endocrinol Metab. 2008;19:3-9.
17. Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest. 2002;32(Suppl 3):14-23.
18. Koutsari C, Jensen MD. Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity. J Lipid Res. 2006;47:1643-1650.
19. Haus JM, Solomon TP, Marchetti CM, etal. Free fatty acid-induced hepatic insulin resistance is attenuated following lifestyle intervention in obese individuals with impaired glucose tolerance. J Clin Endocrinol Metab. 2010;95:323-327.
20. Tansey JT, Sztalryd C, Gruia-Gray J, etal. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci U S A. 2001;98:6494-6499.
21. Miyoshi H, Souza SC, Endo M, etal. Perilipin overexpression in mice protects against diet-induced obesity. J Lipid Res. 2010;51:975-982.
22. Kern PA, Di Gregorio G, Lu T, etal. Perilipin expression in human adipose tissue is elevated with obesity. J Clin Endocrinol Metab. 2004;89:1352-1358.
23. Wang Y, Sullivan S, Trujillo M, etal. Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot. Obes Res. 2003;11:930-936.
24. Mottagui-Tabar S, Ryden M, Lofgren P, etal. Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. Diabetologia. 2003;46:789-797.
25. Nishiu J, Tanaka T, Nakamura Y. Isolation and chromosomal mapping of the human homolog of perilipin (PLIN), a rat adipose tissue-specific gene, by differential display method. Genomics. 1998;48:254-257.
26. Qi L, Corella D, Sorlí JV, etal. Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in white women. Clin Genet. 2004;66:299-310.
27. Qi L, Shen H, Larson I, etal. Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. Obes Res. 2004;12:1758-1765.
28. Qi L, Tai ES, Tan CE, etal. Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. J Mol Med. 2005;83:448-456.
29. Sone Y, Yamaguchi K, Fujiwara A, etal. Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males. J Nutr Sci Vitaminol (Tokyo). 2010;56:123-131.
30. Yan W, Chen S, Huang J, etal. Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese. Obes Res. 2004;12:1733-1737.
31. Meirhaeghe A, Thomas S, Ancot F, etal. Study of the impact of perilipin polymorphisms in a French population. J Negat Results Biomed. 2006;5:10.
32. Bergmann A, Li J, Reimann M, etal. Polymorphisms in perilipin gene (PLIN) are not associated with obesity and weight variation in people with high risk of type 2 diabetes. Exp Clin Endocrinol Diabetes. 2008;116(Suppl 1):S56-S58.
33. Hu DS, Xie J, Yu DH, etal. Perilipin gene 1237 T>C polymorphism is not associated with obesity risk in northern Chinese Han adults. Biomed Environ Sci. 2009;22:442-447.
34. Peeters A, Beckers S, Verrijken A, etal. Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants. Endocrine. 2009;36:103-109.
35. Angeli CB, Kimura L, Auricchio MT, etal. Multilocus analyses of seven candidate genes suggest interacting pathways for obesity-related traits in Brazilian populations. Obesity (Silver Spring). 2011;19:1244-1251.
36. Corella D, Qi L, Sorli JV, etal. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. J Clin Endocrinol Metab. 2005;90:5121-5126.
37. Smith CE, Tucker KL, Yiannakouris N, etal. Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in Hispanics of Caribbean origin. J Nutr. 2008;138:1852-1858.
38. Ruiz JR, Larrarte E, Margareto J, etal. Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women. Br J Nutr. 2011;106:486-490.
39. Labayen I, Diez N, Gonzalez A, etal. Effects of protein versus carbohydrate-rich diets on fuel utilisation in obese women during weight loss. Forum Nutr. 2003;56:168-170.
40. Soenen S, Mariman EC, Vogels N, etal. Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance. Physiol Behav. 2009;96:723-728.
41. Deram S, Nicolau CY, Perez-Martinez P, etal. Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. J Clin Endocrinol Metab. 2008;93:4933-4940.
42. Jang Y, Kim OY, Lee JH, etal. Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss. Int J Obes (Lond). 2006;30:1601-1608.
43. Kang ES, Cha BS, Kim HJ, etal. The 11482G >A polymorphism in the perilipin gene is associated with weight gain with rosiglitazone treatment in type 2 diabetes. Diabetes Care. 2006;29:1320-1324.
44. Dalen KT, Schoonjans K, Ulven SM, etal. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-[gamma]. Diabetes. 2004;53:1243-1252.
45. Arimura N, Horiba T, Imagawa M, etal. The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes. J Biol Chem. 2004;279:10070-10076.
46. Kawai T, Ng MC, Hayes MG, etal. Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. Diabetes Res Clin Pract. 2009;86:186-192.
47. Qi L, Zhang C, Greenberg A, etal. Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women. Obesity (Silver Spring). 2008;16:1061-1065.
48. Ruiz-Narvaez EA, Sacks FM, Campos H. Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction. Am J Clin Nutr. 2008;87:1932-1938.
49. Corella D, Qi L, Tai ES, etal. Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care. 2006;29:1313-1319.
50. Smith CE, Arnett DK, Corella D, etal. Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance. Nutr Metab Cardiovasc Dis. 2012;22:449-455.
51. Tai ES, Ordovas JM. The role of perilipin in human obesity and insulin resistance. Curr Opin Lipidol. 2007;18:152-156.
52. Ordovas JM. Gender, a significant factor in the cross talk between genes, environment, and health. Gend Med. 2007;4(Suppl B):S111-S122.
53. Akter MH, Yamaguchi T, Hirose F, etal. Perilipin, a critical regulator of fat storage and breakdown, is a target gene of estrogen receptor-related receptor alpha. Biochem Biophys Res Commun. 2008;368:563-568.
54. Power ML, Schulkin J. Sex differences in fat storage, fat metabolism, and the health risks from obesity: possible evolutionary origins. Br J Nutr. 2008;99:931-940.
55. Perez-Martinez P, Yiannakouris N, Lopez-Miranda J, etal. Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations. Am J Clin Nutr. 2008;87:744-752.
56. 2max, HDL-C subfractions, and glucose tolerance are influenced by a PLIN haplotype in older Caucasians. J Appl Physiol. 2010;108:498-506.
57. Gaidhu MP, Anthony NM, Patel P, etal. Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK. Am J Physiol Cell Physiol. 2010;298:C961-C971.
58. House RL, Cassady JP, Eisen EJ, etal. Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiol Genomics. 2005;21:351-361.
59. Green A, Rumberger JM, Stuart CA, etal. Stimulation of lipolysis by tumor necrosis factor-alpha in 3T3-L1 adipocytes is glucose dependent: implications for long-term regulation of lipolysis. Diabetes. 2004;53:74-81.
60. Chung S, Brown JM, Sandberg MB, etal. Trans-10, cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling. J Lipid Res. 2005;46:885-895.
61. Ippagunta S, Hadenfeldt TJ, Miner JL, etal. Dietary conjugated linoleic acid induces lipolysis in adipose tissue of coconut oil-fed mice but not soy oil-fed mice. Lipids. 2001;46:821-830.
62. Keophiphath M, Priem F, Jacquemond-Collet I, etal. 1, 2-vinyldithiin from garlic inhibits differentiation and inflammation of human preadipocytes. J Nutr. 2009;139:2055-2060.
63. Hassan M, El Yazidi C, Malezet-Desmoulins C, etal. Gene expression profiling of 3T3-L1 adipocytes exposed to phloretin. J Nutr Biochem. 2010;21:645-652.
64. Abidov MT, del Rio MJ, Ramazanov TZ, etal. Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity. Bull Exp Biol Med. 2006;141:343-346.
65. Wolins NE, Skinner JR, Schoenfish MJ, etal. Adipocyte protein S3-12 coats nascent lipid droplets. J Biol Chem. 2003;278:37713-37721.
66. Consortium. The International HapMap Project. Nature. 2003;426:789-796.
67. 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature. 2010;467(7319):1061-1073.