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Volumn 453, Issue 7195, 2008, Pages 657-661

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; COAT PROTEIN COMPLEX I; COAT PROTEIN COMPLEX II; FAT DROPLET; MEMBRANE LIPID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; VESICULAR TRANSPORT PROTEIN;

EID: 44449095056     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06928     Document Type: Article
Times cited : (606)

References (30)
  • 1
    • 34147152663 scopus 로고    scopus 로고
    • Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic
    • Bartz, R. et al. Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J. Lipid Res. 48, 837-847 (2007).
    • (2007) J. Lipid Res , vol.48 , pp. 837-847
    • Bartz, R.1
  • 2
    • 0035810964 scopus 로고    scopus 로고
    • Lipid droplets: Proteins floating on a pool of fat
    • Brown, D. A. Lipid droplets: proteins floating on a pool of fat. Curr. Biol. 11, R446-R449 (2001).
    • (2001) Curr. Biol , vol.11
    • Brown, D.A.1
  • 3
    • 0037200026 scopus 로고    scopus 로고
    • Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium
    • Miura, S. et al. Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J. Biol. Chem. 277, 32253-32257 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 32253-32257
    • Miura, S.1
  • 4
    • 34548150017 scopus 로고    scopus 로고
    • Dynamic activity of lipid droplets: Protein phosphorylation and GTP-mediated protein translocation
    • Bartz, R. et al. Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J. Proteome Res. 6, 3256-3265 (2007).
    • (2007) J. Proteome Res , vol.6 , pp. 3256-3265
    • Bartz, R.1
  • 5
    • 33646168160 scopus 로고    scopus 로고
    • Lipid droplets: A unified view of a dynamic organelle
    • Martin, S. & Parton, R. G. Lipid droplets: a unified view of a dynamic organelle. Nature Rev. Mol. Cell Biol. 7, 373-378 (2006).
    • (2006) Nature Rev. Mol. Cell Biol , vol.7 , pp. 373-378
    • Martin, S.1    Parton, R.G.2
  • 6
    • 33744910636 scopus 로고    scopus 로고
    • Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells
    • Ulvila, J. et al. Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J. Biol. Chem. 281, 14370-14375 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 14370-14375
    • Ulvila, J.1
  • 7
    • 11144267737 scopus 로고    scopus 로고
    • Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein
    • Shaner, N. C. et al. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nature Biotechnol. 22, 1567-1572 (2004).
    • (2004) Nature Biotechnol , vol.22 , pp. 1567-1572
    • Shaner, N.C.1
  • 8
    • 33748939584 scopus 로고    scopus 로고
    • Prevalence of off-target effects in Drosophila RNA interference screens
    • Ma, Y., Creanga, A., Lum, L. & Beachy, P. A. Prevalence of off-target effects in Drosophila RNA interference screens. Nature 443, 359-363 (2006).
    • (2006) Nature , vol.443 , pp. 359-363
    • Ma, Y.1    Creanga, A.2    Lum, L.3    Beachy, P.A.4
  • 9
    • 33748994797 scopus 로고    scopus 로고
    • Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
    • Kulkarni, M. M. et al. Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nature Methods 3, 833-838 (2006).
    • (2006) Nature Methods , vol.3 , pp. 833-838
    • Kulkarni, M.M.1
  • 10
    • 34247468356 scopus 로고    scopus 로고
    • Genes required for mitotic spindle assembly in Drosophila S2 cells
    • Goshima, G. et al. Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316, 417-421 (2007).
    • (2007) Science , vol.316 , pp. 417-421
    • Goshima, G.1
  • 11
    • 0033613147 scopus 로고    scopus 로고
    • A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
    • Brown, M. S. & Goldstein, J. L. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl Acad. Sci. USA 96, 11041-11048 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 11041-11048
    • Brown, M.S.1    Goldstein, J.L.2
  • 12
    • 0037012907 scopus 로고    scopus 로고
    • Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila
    • Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L.& Rawson, R. B. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science 296, 879-883 (2002).
    • (2002) Science , vol.296 , pp. 879-883
    • Dobrosotskaya, I.Y.1    Seegmiller, A.C.2    Brown, M.S.3    Goldstein, J.L.4    Rawson, R.B.5
  • 13
    • 14644423932 scopus 로고    scopus 로고
    • Regulatory enzymes of phosphatidylcholine biosynthesis: A personal perspective
    • Kent, C. Regulatory enzymes of phosphatidylcholine biosynthesis: a personal perspective. Biochim. Biophys. Acta 1733, 53-66 (2005).
    • (2005) Biochim. Biophys. Acta , vol.1733 , pp. 53-66
    • Kent, C.1
  • 14
    • 0034710302 scopus 로고    scopus 로고
    • Protein kinases and phosphatases in the Drosophila genome
    • Morrison, D. K., Murakami, M. S. & Cleghon, V. Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150, 57-62 (2000).
    • (2000) J. Cell Biol , vol.150 , pp. 57-62
    • Morrison, D.K.1    Murakami, M.S.2    Cleghon, V.3
  • 15
    • 0034284083 scopus 로고    scopus 로고
    • Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization
    • Cornell, R. B. & Northwood, I. C. Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem. Sci. 25, 441-447 (2000).
    • (2000) Trends Biochem. Sci , vol.25 , pp. 441-447
    • Cornell, R.B.1    Northwood, I.C.2
  • 16
    • 0141955219 scopus 로고    scopus 로고
    • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development
    • Weber, U., Eroglu, C. & Mlodzik, M. Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev. Cell 5, 559-570 (2003).
    • (2003) Dev. Cell , vol.5 , pp. 559-570
    • Weber, U.1    Eroglu, C.2    Mlodzik, M.3
  • 17
    • 0035946613 scopus 로고    scopus 로고
    • Roles of lipid polymorphism in intracellular delivery
    • Hafez, I. M. & Cullis, P. R. Roles of lipid polymorphism in intracellular delivery. Adv. Drug Deliv. Rev. 47, 139-148 (2001).
    • (2001) Adv. Drug Deliv. Rev , vol.47 , pp. 139-148
    • Hafez, I.M.1    Cullis, P.R.2
  • 18
    • 0027953550 scopus 로고
    • Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus
    • Dascher, C. & Balch, W. E. Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus. J. Biol. Chem. 269, 1437-1448 (1994).
    • (1994) J. Biol. Chem , vol.269 , pp. 1437-1448
    • Dascher, C.1    Balch, W.E.2
  • 19
    • 25144470244 scopus 로고    scopus 로고
    • Arf1-dependent PLD1 is localized to oleic acid-induced lipid droplets in NIH3T3 cells
    • Nakamura, N., Banno, Y. & Tamiya-Koizumi, K. Arf1-dependent PLD1 is localized to oleic acid-induced lipid droplets in NIH3T3 cells. Biochem. Biophys. Res. Commun. 335, 117-123 (2005).
    • (2005) Biochem. Biophys. Res. Commun , vol.335 , pp. 117-123
    • Nakamura, N.1    Banno, Y.2    Tamiya-Koizumi, K.3
  • 20
    • 0032530193 scopus 로고    scopus 로고
    • Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes
    • Spang, A., Matsuoka, K., Hamamoto, S., Schekman, R. & Orci, L. Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Proc. Natl Acad. Sci. USA 95, 11199-11204 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 11199-11204
    • Spang, A.1    Matsuoka, K.2    Hamamoto, S.3    Schekman, R.4    Orci, L.5
  • 22
    • 33744904687 scopus 로고    scopus 로고
    • The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion
    • Marcinkiewicz, A., Gauthier, D., Garcia, A. & Brasaemle, D. L. The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion. J. Biol. Chem. 281, 11901-11909 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 11901-11909
    • Marcinkiewicz, A.1    Gauthier, D.2    Garcia, A.3    Brasaemle, D.L.4
  • 23
    • 34547616312 scopus 로고    scopus 로고
    • Stimulation of lipolysis enhances the rate of cholesterol efflux to HDL in adipocytes
    • Verghese, P. B., Arrese, E. L. & Soulages, J. L. Stimulation of lipolysis enhances the rate of cholesterol efflux to HDL in adipocytes. Mol. Cell. Biochem. 302, 241-248 (2007).
    • (2007) Mol. Cell. Biochem , vol.302 , pp. 241-248
    • Verghese, P.B.1    Arrese, E.L.2    Soulages, J.L.3
  • 24
    • 31844440878 scopus 로고    scopus 로고
    • Functional genomics reveals genes involved in protein secretion and Golgi organization
    • Bard, F. et al. Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature 439, 604-607 (2006).
    • (2006) Nature , vol.439 , pp. 604-607
    • Bard, F.1
  • 25
    • 33747171783 scopus 로고    scopus 로고
    • The obligate intracellular pathogen Chlamydia trachomatis targets host lipid droplets
    • Kumar, Y., Cocchiaro, J. & Valdivia, R. H. The obligate intracellular pathogen Chlamydia trachomatis targets host lipid droplets. Curr. Biol. 16, 1646-1651 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 1646-1651
    • Kumar, Y.1    Cocchiaro, J.2    Valdivia, R.H.3
  • 26
    • 34548316984 scopus 로고    scopus 로고
    • The lipid droplet is an important organelle for hepatitis C virus production
    • Miyanari, Y. et al. The lipid droplet is an important organelle for hepatitis C virus production. Nature Cell Biol. 9, 1089-1097 (2007).
    • (2007) Nature Cell Biol , vol.9 , pp. 1089-1097
    • Miyanari, Y.1
  • 27
    • 0141768258 scopus 로고    scopus 로고
    • The roles of microtubule-based motor proteins in mitosis: Comprehensive RNAi analysis in the Drosophila S2 cell line
    • Goshima, G. & Vale, R. D. The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line. J. Cell Biol. 162, 1003-1016 (2003).
    • (2003) J. Cell Biol , vol.162 , pp. 1003-1016
    • Goshima, G.1    Vale, R.D.2
  • 28
    • 0141433278 scopus 로고    scopus 로고
    • Molecular requirements for actin-based lamella formation in Drosophila S2 cells
    • Rogers, S. L., Wiedemann, U., Stuurman, N. & Vale, R. D. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J. Cell Biol. 162, 1079-1088 (2003).
    • (2003) J. Cell Biol , vol.162 , pp. 1079-1088
    • Rogers, S.L.1    Wiedemann, U.2    Stuurman, N.3    Vale, R.D.4
  • 29
    • 33644777552 scopus 로고    scopus 로고
    • Rapid, specific, and sensitive measurements of plasma sphingomyelin and phosphatidylcholine
    • Hojjati, M. R. & Jiang, X. C. Rapid, specific, and sensitive measurements of plasma sphingomyelin and phosphatidylcholine. J. Lipid Res. 47, 673-676 (2006).
    • (2006) J. Lipid Res , vol.47 , pp. 673-676
    • Hojjati, M.R.1    Jiang, X.C.2
  • 30
    • 34347235098 scopus 로고    scopus 로고
    • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver
    • Monetti, M. et al. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 6, 69-78 (2007).
    • (2007) Cell Metab , vol.6 , pp. 69-78
    • Monetti, M.1


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