Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Pulido, Marina R ^a,b,c   Diaz Ruiz, Alberto ^a,b,c   Jiménez Gómez, Yolanda ^a,b,c   Garcia Navarro, Socorro ^a,b,c   Gracia Navarro, Francisco ^a,c   Tinahones, Francisco ^b,d   López Miranda, José ^b,c,e   Frühbeck, Gema ^b,f   Vázquez Martínez, Rafael ^a,b,c   Malagón, Maria M ^a,b,c  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c Maimonides Institute for Research in Biomedicine of Cordoba   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^e HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^f UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FAT DROPLET; GUANOSINE TRIPHOSPHATASE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAB18 PROTEIN; UNCLASSIFIED DRUG; ADIPONECTIN; ANTIDIABETIC AGENT; MESSENGER RNA; RAB PROTEIN; RAB18 PROTEIN, MOUSE;

ADIPOCYTE; ADIPOSE TISSUE; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FEMALE; GENE SILENCING; HORMONE ACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; LIPOGENESIS; LIPOLYSIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; ANIMAL; CELL CULTURE; CELL STRAIN 3T3; CYTOLOGY; DRUG EFFECT; ENZYME IMMUNOASSAY; GENETICS; LIPID METABOLISM; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3T3-L1 CELLS; ADIPOCYTES; ADIPONECTIN; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; ENDOPLASMIC RETICULUM; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; IMMUNOENZYME TECHNIQUES; INSULIN; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; MALE; MICE; OBESITY; RAB GTP-BINDING PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 79960904395     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022931     Document Type: Article

References (64)

1. Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS, (2007) Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue. Am J Physiol Gastrointest Liver Physiol 293: G1-4.
2. Kersten S, (2001) Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep 2: 282-286.
3. Langin D, (2006) Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res 53: 482-491.
4. Ahmadian M, Duncan RE, Sul HS, (2009) The skinny on fat: lipolysis and fatty acid utilization in adipocytes. Trends Endocrinol Metab 20: 424-428.
5. Ahmadian M, Wang Y, Sul HS, (2010) Lipolysis in adipocytes. Int J Biochem Cell Biol 42: 555-559.
6. Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS, (2007) Regulation of lipolysis in adipocytes. Annu Rev Nutr 27: 79-101.
7. Fruhbeck G, (2008) Overview of adipose tissue and its role in obesity and metabolic disorders. Methods Mol Biol 456: 1-22.
8. Trayhurn P, Wood IS, (2005) Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33: 1078-1081.
9. Fujimoto T, Ohsaki Y, (2006) Cytoplasmic lipid droplets: rediscovery of an old structure as a unique platform. Ann N Y Acad Sci 1086: 104-115.
10. Murphy DJ, (2001) The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog Lipid Res 40: 325-438.
11. Kuerschner L, Moessinger C, Thiele C, (2008) Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets. Traffic 9: 338-352.
12. Ducharme NA, Bickel PE, (2008) Lipid droplets in lipogenesis and lipolysis. Endocrinology 149: 942-949.
13. Zehmer JK, Huang Y, Peng G, Pu J, Anderson RG, et al. (2009) A role for lipid droplets in inter-membrane lipid traffic. Proteomics 9: 914-921.
14. Kimmel AR, Brasaemle DL, McAndrews-Hill M, Sztalryd C, Londos C, (2010) Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res 51: 468-471.
15. Brasaemle DL, (2007) Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res 48: 2547-2559.
16. Goodman JM, (2008) The gregarious lipid droplet. J Biol Chem 283: 28005-28009.
17. Liu P, Ying Y, Zhao Y, Mundy DI, Zhu M, et al. (2004) Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem 279: 3787-3792.
18. Martin S, Driessen K, Nixon SJ, Zerial M, Parton RG, (2005) Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J Biol Chem 280: 42325-42335.
19. Martin S, Parton RG, (2006) Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol 7: 373-378.
20. Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H, et al. (2005) Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. J Cell Sci 118: 2601-2611.
21. Dejgaard SY, Murshid A, Erman A, Kizilay O, Verbich D, et al. (2008) Rab18 and Rab43 have key roles in ER-Golgi trafficking. J Cell Sci 121: 2768-2781.
22. Lutcke A, Parton RG, Murphy C, Olkkonen VM, Dupree P, et al. (1994) Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression. J Cell Sci 107 (Pt 12): 3437-3448.
23. Vazquez-Martinez R, Cruz-Garcia D, Duran-Prado M, Peinado JR, Castano JP, et al. (2007) Rab18 inhibits secretory activity in neuroendocrine cells by interacting with secretory granules. Traffic 8: 867-882.
24. Wolins NE, Brasaemle DL, Bickel PE, (2006) A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett 580: 5484-5491.
25. Kanzaki M, (2006) Insulin receptor signals regulating GLUT4 translocation and actin dynamics. Endocr J 53: 267-293.
26. Pessin JE, Saltiel AR, (2000) Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest 106: 165-169.
27. Razani B, Lisanti MP, (2001) Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. Am J Physiol Cell Physiol 281: C1241-1250.
28. Brasaemle DL, Levin DM, Adler-Wailes DC, Londos C, (2000) The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets. Biochim Biophys Acta 1483: 251-262.
29. Guest SJ, Hadcock JR, Watkins DC, Malbon CC, (1990) Beta 1- and beta 2-adrenergic receptor expression in differentiating 3T3-L1 cells. Independent regulation at the level of mRNA. J Biol Chem 265: 5370-5375.
30. Lai E, Rosen OM, Rubin CS, (1981) Differentiation-dependent expression of catecholamine-stimulated adenylate cyclase. Roles of the beta-receptor and G/F protein in differentiating 3T3-L1 adipocytes. J Biol Chem 256: 12866-12874.
31. Bartz R, Zehmer JK, Zhu M, Chen Y, Serrero G, et al. (2007) Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J Proteome Res 6: 3256-3265.
32. Cermelli S, Guo Y, Gross SP, Welte MA, (2006) The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr Biol 16: 1783-1795.
33. Fujimoto Y, Itabe H, Sakai J, Makita M, Noda J, et al. (2004) Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim Biophys Acta 1644: 47-59.
34. Cornelius P, MacDougald OA, Lane MD, (1994) Regulation of adipocyte development. Annu Rev Nutr 14: 99-129.
35. Ntambi JM, Young-Cheul K, (2000) Adipocyte differentiation and gene expression. J Nutr 130: 3122S-3126S.
36. Baldini G, Hohl T, Lin HY, Lodish HF, (1992) Cloning of a Rab3 isotype predominantly expressed in adipocytes. Proc Natl Acad Sci U S A 89: 5049-5052.
37. Baldini G, Scherer PE, Lodish HF, (1995) Nonneuronal expression of Rab3A: induction during adipogenesis and association with different intracellular membranes than Rab3D. Proc Natl Acad Sci U S A 92: 4284-4288.
38. Klemm DJ, Leitner JW, Watson P, Nesterova A, Reusch JE, et al. (2001) Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation. J Biol Chem 276: 28430-28435.
39. Wolins NE, Quaynor BK, Skinner JR, Schoenfish MJ, Tzekov A, et al. (2005) S3-12, Adipophilin, and TIP47 package lipid in adipocytes. J Biol Chem 280: 19146-19155.
40. Wolins NE, Skinner JR, Schoenfish MJ, Tzekov A, Bensch KG, et al. (2003) Adipocyte protein S3-12 coats nascent lipid droplets. J Biol Chem 278: 37713-37721.
41. Wolins NE, Quaynor BK, Skinner JR, Tzekov A, Croce MA, et al. (2006) OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 55: 3418-3428.
42. Shibata H, Omata W, Kojima I, (1997) Insulin stimulates guanine nucleotide exchange on Rab4 via a wortmannin-sensitive signaling pathway in rat adipocytes. J Biol Chem 272: 14542-14546.
43. Lafontan M, Langin D, (2009) Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res.
44. Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, et al. (2004) Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279: 48968-48975.
45. Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, et al. (2005) Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes. Mol Cell Endocrinol 240: 43-49.
46. Montero-Moran G, Caviglia JM, McMahon D, Rothenberg A, Subramanian V, et al. (2010) CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase. J Lipid Res 51: 709-719.
47. Brown DA, (2001) Lipid droplets: proteins floating on a pool of fat. Curr Biol 11: R446-449.
48. Zerial M, McBride H, (2001) Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2: 107-117.
49. Grosshans BL, Ortiz D, Novick P, (2006) Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci U S A 103: 11821-11827.
50. Fukuda M, (2006) Rab27 and its effectors in secretory granule exocytosis: a novel docking machinery composed of a Rab27 effector complex. Biochem Soc Trans 34: 691-695.
51. Tsuboi T, Fukuda M, (2006) The Slp4-a linker domain controls exocytosis through interaction with Munc18-1 syntaxin-1a complex. Mol Biol Cell 17: 2101-2112.
52. Tsuboi T, Fukuda M, (2005) The C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cells. J Biol Chem 280: 39253-39259.
53. Lewis GF, Carpentier A, Adeli K, Giacca A, (2002) Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23: 201-229.
54. Shi H, Seeley RJ, Clegg DJ, (2009) Sexual differences in the control of energy homeostasis. Front Neuroendocrinol 30: 396-404.
55. Tchernof A, Belanger C, Morisset AS, Richard C, Mailloux J, et al. (2006) Regional differences in adipose tissue metabolism in women: minor effect of obesity and body fat distribution. Diabetes 55: 1353-1360.
56. Wajchenberg BL, (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21: 697-738.
57. Hurtado Del Pozo C, Calvo RM, Vesperinas-Garcia G, Gomez-Ambrosi J, Fruhbeck G, et al. (2010) Expression Profile in Omental and Subcutaneous Adipose Tissue from Lean and Obese Subjects. Repression of Lipolytic and Lipogenic Genes. Obes Surg.
58. Berndt J, Kralisch S, Kloting N, Ruschke K, Kern M, et al. (2008) Adipose triglyceride lipase gene expression in human visceral obesity. Exp Clin Endocrinol Diabetes 116: 203-210.
59. Ortega FJ, Mayas D, Moreno-Navarrete JM, Catalan V, Gomez-Ambrosi J, et al. (2010) The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects. Obesity (Silver Spring) 18: 13-20.
60. Xie Y, Kang X, Ackerman WEt, Belury MA, Koster C, et al. (2006) Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins. Diabetes Obes Metab 8: 83-93.
61. Momboisse F, Lonchamp E, Calco V, Ceridono M, Vitale N, et al. (2009) betaPIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells. J Cell Sci 122: 798-806.
62. Yu W, Cassara J, Weller PF, (2000) Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Blood 95: 1078-1085.
63. Williams D, Pessin JE, (2008) Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes. J Cell Biol 180: 375-387.
64. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, et al. (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26: 3160-3167.