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Volumn 24, Issue 11, 2010, Pages 4443-4458

Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1

Author keywords

Gene expression; Lipid metabolism; Promoter; Renal clear cell carcinoma

Indexed keywords

ADIPOPHILIN; FAT DROPLET; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE PROTEIN 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 78649805641     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-159806     Document Type: Article
Times cited : (129)

References (52)
  • 1
    • 0036320934 scopus 로고    scopus 로고
    • 2- regulated gene expression
    • 2-regulated gene expression. FASEB J. 16, 1151-1162
    • (2002) FASEB J. , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 2
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin, W. G., Jr., and Ratcliffe, P. J. (2008) Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell. 30, 393-402
    • (2008) Mol. Cell. , vol.30 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 3
    • 0142182781 scopus 로고    scopus 로고
    • HIF-1: An oxygen response system with special relevance to the kidney
    • Maxwell, P. (2003) HIF-1: an oxygen response system with special relevance to the kidney. J. Am. Soc. Nephrol. 14, 2712-2722
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 2712-2722
    • Maxwell, P.1
  • 4
    • 9444283176 scopus 로고    scopus 로고
    • Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells
    • Warnecke, C., Zaborowska, Z., Kurreck, J., Erdmann, V. A., Frei, U., Wiesener, M., and Eckardt, K. U. (2004) Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells. FASEB J. 18, 1462-1464
    • (2004) FASEB J. , vol.18 , pp. 1462-1464
    • Warnecke, C.1    Zaborowska, Z.2    Kurreck, J.3    Erdmann, V.A.4    Frei, U.5    Wiesener, M.6    Eckardt, K.U.7
  • 7
    • 24344488419 scopus 로고    scopus 로고
    • The HIF pathway in cancer
    • Maxwell, P. H. (2005) The HIF pathway in cancer. Semin. Cell. Dev. Biol. 16, 523-530
    • (2005) Semin. Cell. Dev. Biol. , vol.16 , pp. 523-530
    • Maxwell, P.H.1
  • 8
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza, G. L. (2010) Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29, 625-634
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 10
    • 33744954065 scopus 로고    scopus 로고
    • Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: The role of HIF-1α, HIF-2α, and other pathways
    • Elvidge, G. P., Glenny, L., Appelhoff, R. J., Ratcliffe, P. J., Ragoussis, J., and Gleadle, J. M. (2006) Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1α, HIF-2α, and other pathways. J. Biol. Chem. 281, 15215-15226
    • (2006) J. Biol. Chem. , vol.281 , pp. 15215-15226
    • Elvidge, G.P.1    Glenny, L.2    Appelhoff, R.J.3    Ratcliffe, P.J.4    Ragoussis, J.5    Gleadle, J.M.6
  • 11
    • 33745274488 scopus 로고    scopus 로고
    • Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection
    • Aprelikova, O., Wood, M., Tackett, S., Chandramouli, G. V., and Barrett, J. C. (2006) Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res. 66, 5641-5647
    • (2006) Cancer Res. , vol.66 , pp. 5641-5647
    • Aprelikova, O.1    Wood, M.2    Tackett, S.3    Chandramouli, G.V.4    Barrett, J.C.5
  • 12
    • 44749093281 scopus 로고    scopus 로고
    • The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors
    • Warnecke, C., Weidemann, A., Volke, M., Schietke, R., Wu, X., Knaup, K. X., Hackenbeck, T., Bernhardt, W., Willam, C., Eckardt, K. U., and Wiesener, M. S. (2008) The specific contribution of hypoxia-inducible factor-2α to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp. Cell. Res. 314, 2016-2027
    • (2008) Exp. Cell. Res. , vol.314 , pp. 2016-2027
    • Warnecke, C.1    Weidemann, A.2    Volke, M.3    Schietke, R.4    Wu, X.5    Knaup, K.X.6    Hackenbeck, T.7    Bernhardt, W.8    Willam, C.9    Eckardt, K.U.10    Wiesener, M.S.11
  • 13
    • 0033970086 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment
    • Denko, N., Schindler, C., Koong, A., Laderoute, K., Green, C., and Giaccia, A. (2000) Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin. Cancer Res. 6, 480-487
    • (2000) Clin. Cancer Res. , vol.6 , pp. 480-487
    • Denko, N.1    Schindler, C.2    Koong, A.3    Laderoute, K.4    Green, C.5    Giaccia, A.6
  • 14
    • 17144416530 scopus 로고    scopus 로고
    • Differential gene up-regulation by hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in HEK293T cells
    • Wang, V., Davis, D. A., Haque, M., Huang, L. E., and Yarchoan, R. (2005) Differential gene up-regulation by hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in HEK293T cells. Cancer Res. 65, 3299-3306
    • (2005) Cancer Res. , vol.65 , pp. 3299-3306
    • Wang, V.1    Davis, D.A.2    Haque, M.3    Huang, L.E.4    Yarchoan, R.5
  • 15
    • 13144286421 scopus 로고    scopus 로고
    • Receptor and secreted targets of Wnt-1/β-catenin signalling in mouse mammary epithelial cells
    • Kenny, P. A., Enver, T., and Ashworth, A. (2005) Receptor and secreted targets of Wnt-1/β-catenin signalling in mouse mammary epithelial cells. BMC Cancer 5, 3
    • (2005) BMC Cancer , vol.5 , pp. 3
    • Kenny, P.A.1    Enver, T.2    Ashworth, A.3
  • 18
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia
    • Sowter, H. M., Raval, R. R., Moore, J. W., Ratcliffe, P. J., and Harris, A. L. (2003) Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia. Cancer Res. 63, 6130-6134
    • (2003) Cancer Res. , vol.63 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.R.2    Moore, J.W.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 21
    • 38149110580 scopus 로고    scopus 로고
    • Hypoxia, via stabilization of hypoxia-inducible factor HIF-1α is a direct and sufficient stimulus for brain-type natriuretic peptide induction
    • Weidemann, A., Klanke, B., Wagner, M., Volk, T., Willam, C., Wiesener, M. S., Eckardt, K. U., and Warnecke, C. (2008) Hypoxia, via stabilization of hypoxia-inducible factor HIF-1α is a direct and sufficient stimulus for brain-type natriuretic peptide induction. Biochem. J. 409, 233-242
    • (2008) Biochem. J. , vol.409 , pp. 233-242
    • Weidemann, A.1    Klanke, B.2    Wagner, M.3    Volk, T.4    Willam, C.5    Wiesener, M.S.6    Eckardt, K.U.7    Warnecke, C.8
  • 22
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts
    • Mole, D. R., Blancher, C., Copley, R. R., Pollard, P. J., Gleadle, J. M., Ragoussis, J., and Ratcliffe, P. J. (2009) Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts. J. Biol. Chem. 284, 16767-16775
    • (2009) J. Biol. Chem. , vol.284 , pp. 16767-16775
    • Mole, D.R.1    Blancher, C.2    Copley, R.R.3    Pollard, P.J.4    Gleadle, J.M.5    Ragoussis, J.6    Ratcliffe, P.J.7
  • 24
    • 66349128492 scopus 로고    scopus 로고
    • PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores
    • Bickel, P. E., Tansey, J. T., and Welte, M. A. (2009) PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim. Biophys. Acta 1791, 419-440
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 419-440
    • Bickel, P.E.1    Tansey, J.T.2    Welte, M.A.3
  • 26
    • 0017829082 scopus 로고
    • Control of fatty acid metabolism in ischemic and hypoxic hearts
    • Whitmer, J. T., Idell-Wenger, J. A., Rovetto, M. J., and Neely, J. R. (1978) Control of fatty acid metabolism in ischemic and hypoxic hearts. J. Biol. Chem. 253, 4305-4309
    • (1978) J. Biol. Chem. , vol.253 , pp. 4305-4309
    • Whitmer, J.T.1    Idell-Wenger, J.A.2    Rovetto, M.J.3    Neely, J.R.4
  • 27
    • 0017746174 scopus 로고
    • Lipid accumulation of hypoxic tissue culture cells
    • Gordon, G. B., Barcza, M. A., and Bush, M. E. (1977) Lipid accumulation of hypoxic tissue culture cells. Am. J. Pathol. 88, 663-678
    • (1977) Am. J. Pathol. , vol.88 , pp. 663-678
    • Gordon, G.B.1    Barcza, M.A.2    Bush, M.E.3
  • 28
  • 29
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., and Semenza, G. L. (2007) HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11, 407-420
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1    Gao, P.2    Fukuda, R.3    Kumar, G.4    Krishnamachary, B.5    Zeller, K.I.6    Dang, C.V.7    Semenza, G.L.8
  • 30
    • 35649023152 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor α/retinoid X receptor
    • Belanger, A. J., Luo, Z., Vincent, K. A., Akita, G. Y., Cheng, S. H., Gregory, R. J., and Jiang, C. (2007) Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor α/retinoid X receptor. Biochem. Biophys. Res. Commun. 364, 567-572
    • (2007) Biochem. Biophys. Res. Commun. , vol.364 , pp. 567-572
    • Belanger, A.J.1    Luo, Z.2    Vincent, K.A.3    Akita, G.Y.4    Cheng, S.H.5    Gregory, R.J.6    Jiang, C.7
  • 32
    • 0036660804 scopus 로고    scopus 로고
    • Hypoxia up-regulates expression of peroxisome proliferator-activated receptor γ angiopoietin-related gene (PGAR) in cardiomyocytes: Role of hypoxia inducible factor 1α
    • Belanger, A. J., Lu, H., Date, T., Liu, L. X., Vincent, K. A., Akita, G. Y., Cheng, S. H., Gregory, R. J., and Jiang, C. (2002) Hypoxia up-regulates expression of peroxisome proliferator-activated receptor γ angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1α. J. Mol. Cell. Cardiol. 34, 765-774
    • (2002) J. Mol. Cell. Cardiol. , vol.34 , pp. 765-774
    • Belanger, A.J.1    Lu, H.2    Date, T.3    Liu, L.X.4    Vincent, K.A.5    Akita, G.Y.6    Cheng, S.H.7    Gregory, R.J.8    Jiang, C.9
  • 33
    • 0037163861 scopus 로고    scopus 로고
    • Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia
    • Saarikoski, S. T., Rivera, S. P., and Hankinson, O. (2002) Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia. FEBS Lett. 530, 186-190
    • (2002) FEBS Lett. , vol.530 , pp. 186-190
    • Saarikoski, S.T.1    Rivera, S.P.2    Hankinson, O.3
  • 34
    • 67650083112 scopus 로고    scopus 로고
    • Oleic acid-induced ADRP expression requires both AP-1 and PPAR response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells
    • Fan, B., Ikuyama, S., Gu, J. Q., Wei, P., Oyama, J., Inoguchi, T., and Nishimura, J. (2009) Oleic acid-induced ADRP expression requires both AP-1 and PPAR response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells. Am. J. Physiol. Endocrinol. Metab. 297, E112-E123
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297
    • Fan, B.1    Ikuyama, S.2    Gu, J.Q.3    Wei, P.4    Oyama, J.5    Inoguchi, T.6    Nishimura, J.7
  • 37
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
    • Hu, C. J., Wang, L. Y., Chodosh, L. A., Keith, B., and Simon, M. C. (2003) Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol. Cell. Biol. 23, 9361-9374
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 38
    • 43649100536 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
    • Lei, L., Mason, S., Liu, D., Huang, Y., Marks, C., Hickey, R., Jovin, I. S., Pypaert, M., Johnson, R. S., and Giordano, F. J. (2008) Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol. Cell. Biol. 28, 3790-3803
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 3790-3803
    • Lei, L.1    Mason, S.2    Liu, D.3    Huang, Y.4    Marks, C.5    Hickey, R.6    Jovin, I.S.7    Pypaert, M.8    Johnson, R.S.9    Giordano, F.J.10
  • 40
    • 40849145708 scopus 로고    scopus 로고
    • Lipid droplets in lipogenesis and lipolysis
    • Ducharme, N. A., and Bickel, P. E. (2008) Lipid droplets in lipogenesis and lipolysis. Endocrinology 149, 942-949
    • (2008) Endocrinology , vol.149 , pp. 942-949
    • Ducharme, N.A.1    Bickel, P.E.2
  • 41
    • 36649009407 scopus 로고    scopus 로고
    • Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover
    • Listenberger, L. L., Ostermeyer-Fay, A. G., Goldberg, E. B., Brown, W. J., and Brown, D. A. (2007) Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover. J. Lipid Res. 48, 2751-2761
    • (2007) J. Lipid Res. , vol.48 , pp. 2751-2761
    • Listenberger, L.L.1    Ostermeyer-Fay, A.G.2    Goldberg, E.B.3    Brown, W.J.4    Brown, D.A.5
  • 43
    • 66749187756 scopus 로고    scopus 로고
    • Novel concepts in atherogenesis: Angiogenesis and hypoxia in atherosclerosis
    • Sluimer, J. C., and Daemen, M. J. (2009) Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J. Pathol. 218, 7-29
    • (2009) J. Pathol. , vol.218 , pp. 7-29
    • Sluimer, J.C.1    Daemen, M.J.2
  • 44
    • 34147122736 scopus 로고    scopus 로고
    • RNA interference for HIF-1α inhibits foam cells formation in vitro
    • Jiang, G., Li, T., Qiu, Y., Rui, Y., Chen, W., and Lou, Y. (2007) RNA interference for HIF-1α inhibits foam cells formation in vitro. Eur. J. Pharmacol. 562, 183-190
    • (2007) Eur. J. Pharmacol. , vol.562 , pp. 183-190
    • Jiang, G.1    Li, T.2    Qiu, Y.3    Rui, Y.4    Chen, W.5    Lou, Y.6
  • 45
    • 73149109067 scopus 로고    scopus 로고
    • Hypoxia and non alcoholic fatty liver disease
    • Byrne, C. D. (2009) Hypoxia and non alcoholic fatty liver disease. Clin. Sci. (Lond.) 118, 397-400
    • (2009) Clin. Sci. (Lond.) , vol.118 , pp. 397-400
    • Byrne, C.D.1
  • 48
    • 50949107027 scopus 로고    scopus 로고
    • Consequences of lipid droplet coat protein downregulation in liver cells: Abnormal lipid droplet metabolism and induction of insulin resistance
    • Bell, M., Wang, H., Chen, H., McLenithan, J. C., Gong, D. W., Yang, R. Z., Yu, D., Fried, S. K., Quon, M. J., Londos, C., and Sztalryd, C. (2008) Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance. Diabetes 57, 2037-2045
    • (2008) Diabetes , vol.57 , pp. 2037-2045
    • Bell, M.1    Wang, H.2    Chen, H.3    McLenithan, J.C.4    Gong, D.W.5    Yang, R.Z.6    Yu, D.7    Fried, S.K.8    Quon, M.J.9    Londos, C.10    Sztalryd, C.11
  • 52
    • 13844254987 scopus 로고    scopus 로고
    • Gene expression analysis of renal carcinoma: Adipose differentiation- related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma
    • Yao, M., Tabuchi, H., Nagashima, Y., Baba, M., Nakaigawa, N., Ishiguro, H., Hamada, K., Inayama, Y., Kishida, T., Hattori, K., Yamada-Okabe, H., and Kubota, Y. (2005) Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J. Pathol. 205, 377-387
    • (2005) J. Pathol. , vol.205 , pp. 377-387
    • Yao, M.1    Tabuchi, H.2    Nagashima, Y.3    Baba, M.4    Nakaigawa, N.5    Ishiguro, H.6    Hamada, K.7    Inayama, Y.8    Kishida, T.9    Hattori, K.10    Yamada-Okabe, H.11    Kubota, Y.12


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