The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

Journal of Lipid Research

Volumn 53, Issue 6, 2012, Pages 1106-1116

  Qi, Jenson ^a   Lang, Wensheng ^a   Geisler, John G ^a   Wang, Ping ^a   Petrounia, Ioanna ^a   Mai, Selyna ^a   Smith, Charles ^a   Askari, Hossein ^a   Struble, Geoffrey T ^a   Williams, Robyn ^a   Bhanot, Sanjay ^b   Monia, Brett P ^b   Bayoumy, Shariff ^a   Grant, Eugene ^a   Caldwell, Gary W ^a   Todd, Matthew J ^a   Liang, Yin ^a   Gaul, Micheal D ^a   Demarest, Keith T ^a   Connelly, Margery A ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

13C 18 oleic acid; 13C 3 D 5 glycerol; Diacylglycerol acyltransferase; Liquid chromatography tandem mass spectrometry; Triglyceride synthesis; Very low density lipoprotein triglyceride

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CARBON 13; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIACYLGLYCEROL ACYLTRANSFERASE 1 INHIBITOR; DIACYLGLYCEROL ACYLTRANSFERASE 2; DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR; ENZYME INHIBITOR; GLYCEROL; OLEIC ACID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; HEPATOMA CELL; IN VIVO STUDY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIACYLGLYCEROL O-ACYLTRANSFERASE; ENZYME ASSAYS; ENZYME INHIBITORS; ESTERIFICATION; FATTY ACIDS; GLYCEROL; HEP G2 CELLS; HUMANS; ISOTOPE LABELING; LIPOPROTEINS, VLDL; LIVER; MALE; MICE; OLEIC ACID; OLIGONUCLEOTIDES, ANTISENSE; TRIGLYCERIDES;

EID: 84861425644     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M020156     Document Type: Article

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