-
2
-
-
66449125127
-
A history of drug discovery
-
C.G. Wermuth, 3rd ed. Elsevier Academic Press Burlington, MA
-
F. Chast A history of drug discovery C.G. Wermuth, Wermuth's the practice of medicinal chemistry 3rd ed. 2008 Elsevier Academic Press Burlington, MA 3 62
-
(2008)
Wermuth's the Practice of Medicinal Chemistry
, pp. 3-62
-
-
Chast, F.1
-
4
-
-
85011095670
-
The development of the pharmaceutical industry
-
R.G. Hill, H.P. Rang, 2nd Ed Churchill Livingstone London
-
H.P. Rang The development of the pharmaceutical industry R.G. Hill, H.P. Rang, Drug discovery and development. Technology in transition 2nd Ed 2013 Churchill Livingstone London 3 18
-
(2013)
Drug Discovery and Development. Technology in Transition
, pp. 3-18
-
-
Rang, H.P.1
-
5
-
-
81055138684
-
-
McKinsey Global Institution
-
J. Manyika, M. Chui, B. Brown, J. Bughin, R. Dobbs, and C. Roxburgh et al. Big data: the next frontier for innovation, competition, and productivity 2011 McKinsey Global Institution http://www.mckinsey.com/insights/business- technology/big-data-the-next-frontier-for-innovation
-
(2011)
Big Data: The Next Frontier for Innovation, Competition, and Productivity
-
-
Manyika, J.1
Chui, M.2
Brown, B.3
Bughin, J.4
Dobbs, R.5
Roxburgh, C.6
-
6
-
-
37549003686
-
An interview with. Sydney Brenner. Interview by Errol C. Friedberg
-
S. Brenner An interview with. Sydney Brenner. Interview by Errol C. Friedberg Nat Rev Mol Cell Biol 9 2008 8 9
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 8-9
-
-
Brenner, S.1
-
7
-
-
0028453197
-
The essential role of integrative biomedical sciences in protecting and contributing to the health and well being of our nation
-
P.C. Jobe, L.E. Adams-Curtis, T.F. Burks, R.W. Fuller, C.C. Peck, and R.R. Ruffolo et al. The essential role of integrative biomedical sciences in protecting and contributing to the health and well being of our nation Physiologist 37 1994 79 84
-
(1994)
Physiologist
, vol.37
, pp. 79-84
-
-
Jobe, P.C.1
Adams-Curtis, L.E.2
Burks, T.F.3
Fuller, R.W.4
Peck, C.C.5
Ruffolo, R.R.6
-
8
-
-
0037313517
-
Modern biomedical research: An internally self consistent universe with little contact with medical reality?
-
Horrabin DF: Modern biomedical research: an internally self consistent universe with little contact with medical reality? Nat Rev Drug Discov 2 2003 151 154
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 151-154
-
-
Df, H.1
-
10
-
-
0142209376
-
Attrition and Translation
-
DOI 10.1126/science.1090521
-
G. Duyk Attrition and translation Science 302 2003 603 605 (Pubitemid 37310908)
-
(2003)
Science
, vol.302
, Issue.5645
, pp. 603-605
-
-
Duyk, G.1
-
11
-
-
27744572131
-
Systems and integrative biology as alternative guises for pharmacology: Prime time for an iPharm concept?
-
DOI 10.1016/j.bcp.2005.08.019, PII S000629520500568X
-
M. Williams Systems and integrative biology as alternative guises for pharmacology: prime time for an iPharm concept? Biochem Pharmacol 70 2005 1707 1716 (Pubitemid 41612001)
-
(2005)
Biochemical Pharmacology
, vol.70
, Issue.12
, pp. 1707-1716
-
-
Williams, M.1
-
12
-
-
38049096095
-
The meaning of translational research and why it matters
-
S.H. Woolf The meaning of translational research and why it matters J Am Med Assoc 299 2008 211 213
-
(2008)
J Am Med Assoc
, vol.299
, pp. 211-213
-
-
Woolf, S.H.1
-
13
-
-
67650069258
-
Assessing the translatability of drug projects: What needs to be scored to predict success?
-
M. Wehling Assessing the translatability of drug projects: what needs to be scored to predict success? Nat Rev Drug Discov 8 2009 541 546
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 541-546
-
-
Wehling, M.1
-
14
-
-
7444253428
-
Systems biology and new technologies enable predictive and preventative medicine
-
DOI 10.1126/science.1104635
-
L. Hood, J.R. Heath, M.E. Phelps, and B. Lin Systems biology and new technologies enable predictive and preventative medicine Science 306 2004 640 643 (Pubitemid 39440903)
-
(2004)
Science
, vol.306
, Issue.5696
, pp. 640-643
-
-
Hood, L.1
Heath, J.R.2
Phelps, M.E.3
Lin, B.4
-
15
-
-
84858784781
-
Merging systems biology with pharmacodynamics
-
126ps7
-
R. Iyengar, S. Zhao, S.W. Chung, D.E. Mager, and J.M. Gallo Merging systems biology with pharmacodynamics Sci Transl Med 4 2012 126ps7
-
(2012)
Sci Transl Med
, vol.4
-
-
Iyengar, R.1
Zhao, S.2
Chung, S.W.3
Mager, D.E.4
Gallo, J.M.5
-
16
-
-
79959900575
-
Systems pharmacology: Bridging systems biology and pharmacokinetics- pharmacodynamics (PKPD) in drug discovery and development
-
P.H. van der Graaf, and N. Benson Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development Pharm Res 28 2011 1460 1464
-
(2011)
Pharm Res
, vol.28
, pp. 1460-1464
-
-
Van Der Graaf, P.H.1
Benson, N.2
-
20
-
-
84875275699
-
Human diseases through the lens of network biology
-
L.I. Furlong Human diseases through the lens of network biology Trends Genetics 29 2013 150 159
-
(2013)
Trends Genetics
, vol.29
, pp. 150-159
-
-
Furlong, L.I.1
-
21
-
-
84877580262
-
Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review
-
P. Csermely, T. Korcsmáros, H.J.M. Kiss, G. London, and R. Nussinov Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review Pharmacol Ther 138 2013 333 408
-
(2013)
Pharmacol Ther
, vol.138
, pp. 333-408
-
-
Csermely, P.1
Korcsmáros, T.2
Kiss, H.J.M.3
London, G.4
Nussinov, R.5
-
22
-
-
78650373804
-
Network medicine: A network-based approach to human disease
-
A.-L. Barabási, N. Gulbahce, and J. Loscalzo Network medicine: a network-based approach to human disease Nat Rev Genet 12 2011 56 68
-
(2011)
Nat Rev Genet
, vol.12
, pp. 56-68
-
-
Barabási, A.-L.1
Gulbahce, N.2
Loscalzo, J.3
-
23
-
-
84871344105
-
-
P.K. Sorger, S.R.B. Allerheiligen, D.R. Abernethy, R.B. Altman, K.L.R. Brouwer, and A. Califano et al. Quantitative and systems pharmacology in the post-genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms 2011 http://isp.hms.harvard.edu/wordpress/wp-content/ uploads/2011/10/NIH-Systems-Pharma-Whitepaper-Sorger-et-al-2011.pdf
-
(2011)
Quantitative and Systems Pharmacology in the Post-genomic Era: New Approaches to Discovering Drugs and Understanding Therapeutic Mechanisms
-
-
Sorger, P.K.1
Allerheiligen, S.R.B.2
Abernethy, D.R.3
Altman, R.B.4
Brouwer, K.L.R.5
Califano, A.6
-
24
-
-
84881151372
-
NIH support for the emergence of quantitative and systems pharmacology
-
M. Rogers, P. Lyster, and R. Okita NIH support for the emergence of quantitative and systems pharmacology CPT: Pharmacometr Syst Pharmacol 2 2013 e37
-
(2013)
CPT: Pharmacometr Syst Pharmacol
, vol.2
, pp. 37
-
-
Rogers, M.1
Lyster, P.2
Okita, R.3
-
25
-
-
77957657385
-
A life in new drug research
-
J. Black A life in new drug research Br J Pharmacol 160 Suppl. 1 2010 S15 S25
-
(2010)
Br J Pharmacol
, vol.160
, Issue.SUPPL. 1
-
-
Black, J.1
-
26
-
-
78650798983
-
Productivity shortfalls in drug discovery: Contributions from the preclinical sciences?
-
M. Williams Productivity shortfalls in drug discovery: contributions from the preclinical sciences? J Pharmacol Exp Ther 336 2011 3 8
-
(2011)
J Pharmacol Exp Ther
, vol.336
, pp. 3-8
-
-
Williams, M.1
-
27
-
-
73449101512
-
Lessons from 60 years of pharmaceutical innovation
-
B. Munos Lessons from 60 years of pharmaceutical innovation Nat Rev Drug Discov 8 2009 959 968
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 959-968
-
-
Munos, B.1
-
30
-
-
0001341562
-
High-content screening: A new approach to easing key bottlenecks in the drug discovery process
-
K.A. Giuliano, R.L. DeBiasio, R.T. Dunlay, A. Gough, J.M. Volosky, and J. Zock et al. High-content screening: a new approach to easing key bottlenecks in the drug discovery process J Biomol Screen 2 1997 249 259 (Pubitemid 127690015)
-
(1997)
Journal of Biomolecular Screening
, vol.2
, Issue.4
, pp. 249-259
-
-
Giuliano, K.A.1
Debiasio, R.L.2
Terry Dunlay, R.3
Gough, A.4
Volosky, J.M.5
Zock, J.6
Pavlakis, G.N.7
Lansing Taylor, D.8
-
31
-
-
84906465113
-
Traditional medicines
-
L. Mitscher Traditional medicines Comp Med Chem II 1 2007 406 430
-
(2007)
Comp Med Chem II
, vol.1
, pp. 406-430
-
-
Mitscher, L.1
-
32
-
-
0035899915
-
Herbal medicines today and the roots of modern pharmacology
-
P. Goldman Herbal medicines today and the roots of modern pharmacology Ann Intern Med 135 2001 594 600 (Pubitemid 33010195)
-
(2001)
Annals of Internal Medicine
, vol.135
, Issue.8
, pp. 594-600
-
-
Goldman, P.1
-
33
-
-
84886148029
-
Natural products in drug discovery: Recent advances
-
V. Cechinel-Filho, 4th ed. Wiley Hoboken
-
G.M. Cragg, P.G. Grothaus, and D.J. Newman Natural products in drug discovery: recent advances V. Cechinel-Filho, Plant bioactives and drug discovery: principles, practice, and perspectives 4th ed. 2012 Wiley Hoboken 1 42
-
(2012)
Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives
, pp. 1-42
-
-
Cragg, G.M.1
Grothaus, P.G.2
Newman, D.J.3
-
34
-
-
66449086421
-
Evolution of the pharmaceutical industry
-
J. Liebenau Evolution of the pharmaceutical industry Comp Med Chem I 1 1990 81 98
-
(1990)
Comp Med Chem i
, vol.1
, pp. 81-98
-
-
Liebenau, J.1
-
36
-
-
70349612281
-
Academic collaboration and organizational innovation: The development of research capabilities in the US pharmaceutical industry, 1927-1946
-
J.L. Furman, and M. MacGarvie Academic collaboration and organizational innovation: the development of research capabilities in the US pharmaceutical industry, 1927-1946 Ind Corp Change 18 2009 929 961
-
(2009)
Ind Corp Change
, vol.18
, pp. 929-961
-
-
Furman, J.L.1
Macgarvie, M.2
-
38
-
-
79851477450
-
The role of public-sector research in the discovery of drugs and vaccines
-
A.J. Stevens, J.J. Jensen, K. Wyller, and P.C. Kilgore et al. The role of public-sector research in the discovery of drugs and vaccines New Eng. J Med 364 2011 535 541
-
(2011)
New Eng. J Med
, vol.364
, pp. 535-541
-
-
Stevens, A.J.1
Jensen, J.J.2
Wyller, K.3
Kilgore, P.C.4
-
39
-
-
84892366319
-
When the pill peddlers met the scientists: The antecedents and implications of early collaborations between US pharmaceutical firms and universities
-
J.L. Furman, and M. MacGarvie When the pill peddlers met the scientists: the antecedents and implications of early collaborations between US pharmaceutical firms and universities Essay Econ Bus History XXVI 2008 138 146
-
(2008)
Essay Econ Bus History
, vol.26
, pp. 138-146
-
-
Furman, J.L.1
Macgarvie, M.2
-
40
-
-
77956796338
-
Drug discovery in academia - The third way?
-
J. Frearson, and P. Wyatt Drug discovery in academia - the third way? Exp Opin Drug Discov 5 2010 909 919
-
(2010)
Exp Opin Drug Discov
, vol.5
, pp. 909-919
-
-
Frearson, J.1
Wyatt, P.2
-
41
-
-
84885003207
-
Contributions of academic laboratories to the discovery and development of chemical biology tools
-
D.M. Huryn, L.O. Resnick, and P. Wipf Contributions of academic laboratories to the discovery and development of chemical biology tools J Med Chem 56 2013 7161 7176
-
(2013)
J Med Chem
, vol.56
, pp. 7161-7176
-
-
Huryn, D.M.1
Resnick, L.O.2
Wipf, P.3
-
43
-
-
80055088241
-
Believe it or not: How much can we rely on published data on potential drug targets?
-
F. Prinz, T. Schlange, and K. Asadullah Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov 10 2011 712 713
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 712-713
-
-
Prinz, F.1
Schlange, T.2
Asadullah, K.3
-
44
-
-
84859169880
-
Raise standards for preclinical cancer research
-
C.G. Begley, and L.M. Ellis Raise standards for preclinical cancer research Nature 483 2012 531 533
-
(2012)
Nature
, vol.483
, pp. 531-533
-
-
Begley, C.G.1
Ellis, L.M.2
-
45
-
-
84877752060
-
A survey on data reproducibility in cancer research provides insights into our limited ability to translate findings from the laboratory to the clinic
-
e63221
-
A. Mobley, S.K. Linder, R. Braeuer, L.M. Ellis, and L. Zwelling A survey on data reproducibility in cancer research provides insights into our limited ability to translate findings from the laboratory to the clinic PLoS ONE 8 2013 e63221
-
(2013)
PLoS ONE
, vol.8
-
-
Mobley, A.1
Linder, S.K.2
Braeuer, R.3
Ellis, L.M.4
Zwelling, L.5
-
46
-
-
33745932862
-
Traditional Chinese medicine and kampo: A review from the distant past for the future
-
F. Yu, T. Takahashi, J. Moriya, K. Kawaura, J. Yamakawa, and K. Kusaka et al. Traditional Chinese medicine and Kampo: a review from the distant past for the future J Int Med Res 34 2006 231 239 (Pubitemid 44057265)
-
(2006)
Journal of International Medical Research
, vol.34
, Issue.3
, pp. 231-239
-
-
Yu, F.1
Takahashi, T.2
Moriya, J.3
Kawaura, K.4
Yamakawa, J.5
Kusaka, K.6
Itoh, T.7
Morimoto, S.8
Yamaguchi, N.9
Kanda, T.10
-
47
-
-
78649907347
-
Systems biology-based diagnostic principles as pillars of the bridge between chinese and western medicine
-
J. van der Greef, H. van Wietmarschen, J. Schroro, M. Wang, T. Hankemeier, and G. Xu Systems biology-based diagnostic principles as pillars of the bridge between chinese and western medicine Planta Med 76 2010 2036 2047
-
(2010)
Planta Med
, vol.76
, pp. 2036-2047
-
-
Van Der Greef, J.1
Van Wietmarschen, H.2
Schroro, J.3
Wang, M.4
Hankemeier, T.5
Xu, G.6
-
48
-
-
73849123558
-
Interactions between traditional Chinese medicines and Western therapeutics
-
E. Chan, M. Tan, J. Xin, S. Sudarsanam, and D.E. Johnson Interactions between traditional Chinese medicines and Western therapeutics Curr Opin Drug Discov Dev 13 2010 50 65
-
(2010)
Curr Opin Drug Discov Dev
, vol.13
, pp. 50-65
-
-
Chan, E.1
Tan, M.2
Xin, J.3
Sudarsanam, S.4
Johnson, D.E.5
-
49
-
-
11344292132
-
The role of natural product chemistry in drug discovery
-
DOI 10.1021/np040106y
-
M.S. Butler The role of natural product chemistry in drug discovery J Nat Prod 64 2004 2141 2153 (Pubitemid 40092578)
-
(2004)
Journal of Natural Products
, vol.67
, Issue.12
, pp. 2141-2153
-
-
Butler, M.S.1
-
50
-
-
62149117325
-
Discovery of natural product anticancer agents from biodiverse organisms
-
A.D. Kinghorn, Y.-W. Chin, and S.M. Swanson Discovery of natural product anticancer agents from biodiverse organisms Curr Opin Drug Discov Dev 12 2009 189 196
-
(2009)
Curr Opin Drug Discov Dev
, vol.12
, pp. 189-196
-
-
Kinghorn, A.D.1
Chin, Y.-W.2
Swanson, S.M.3
-
51
-
-
33845708150
-
New antibiotics from bacterial natural products
-
DOI 10.1038/nbt1266, PII NBT1266
-
J. Clardy, M.A. Fischbach, and C.T. Walsh New antibiotics from bacterial natural products Nat Biotechnol 24 2006 1541 1550 (Pubitemid 44967478)
-
(2006)
Nature Biotechnology
, vol.24
, Issue.12
, pp. 1541-1550
-
-
Clardy, J.1
Fischbach, M.A.2
Walsh, C.T.3
-
52
-
-
67651149831
-
Epibatidine: From frog alkaloid to analgesic drug candidates. A testimonial to "true Grit"!
-
H.M. Garraffo, T.F. Spande, and M. Williams Epibatidine: from frog alkaloid to analgesic drug candidates. A testimonial to "True Grit"! Heterocycles 79 2009 207 217
-
(2009)
Heterocycles
, vol.79
, pp. 207-217
-
-
Garraffo, H.M.1
Spande, T.F.2
Williams, M.3
-
53
-
-
33749645832
-
Ziconotide - A novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain - A short review
-
U. Klotz Ziconotide - a novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain - a short review Int J Clin Pharmacol Ther 44 2006 478 483 (Pubitemid 44540941)
-
(2006)
International Journal of Clinical Pharmacology and Therapeutics
, vol.44
, Issue.10
, pp. 478-483
-
-
Klotz, U.1
-
54
-
-
80053651851
-
Desmoteplase: Discovery, insights and opportunities for ischemic stroke
-
R.L. Medcalf Desmoteplase: discovery, insights and opportunities for ischemic stroke Br J Pharmacol 165 2012 75 89
-
(2012)
Br J Pharmacol
, vol.165
, pp. 75-89
-
-
Medcalf, R.L.1
-
55
-
-
37549019221
-
A brief history of great discoveries in pharmacology: In celebration of the centennial anniversary of the founding of the American Society of Pharmacology and Experimental Therapeutics
-
R.P. Rubin A brief history of great discoveries in pharmacology: in celebration of the centennial anniversary of the founding of the American Society of Pharmacology and Experimental Therapeutics Pharmacol Rev 59 2007 289 359
-
(2007)
Pharmacol Rev
, vol.59
, pp. 289-359
-
-
Rubin, R.P.1
-
56
-
-
42949175085
-
Paul Ehrlich: Founder of chemotherapy
-
DOI 10.1038/nrd2582, PII NRD2582
-
S.H.E. Kaufmann Paul Ehrlich: founder of chemotherapy Nat Rev Drug Discov 7 2008 373 (Pubitemid 351619105)
-
(2008)
Nature Reviews Drug Discovery
, vol.7
, Issue.5
, pp. 373
-
-
Kaufmann, S.H.E.1
-
57
-
-
44449085539
-
Paul Ehrlich's magic bullet concept: 100 Years of progress
-
DOI 10.1038/nrc2394, PII NRC2394
-
K. Strebhardt, and A. Ullrich Paul Ehrlich's magic bullet concept: 100 years of progress Nat Rev Cancer 8 2008 473 480 (Pubitemid 351752547)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.6
, pp. 473-480
-
-
Strebhardt, K.1
Ullrich, A.2
-
58
-
-
0033981982
-
The concept of transmitter receptors: 100 years on
-
DOI 10.1016/S0028-3908(99)00137-9, PII S0028390899001379
-
M.R. Bennett The concept of transmitter receptors: 100 years on Neuropharmacology 39 2000 523 546 (Pubitemid 30089303)
-
(2000)
Neuropharmacology
, vol.39
, Issue.4
, pp. 523-546
-
-
Bennett, M.R.1
-
60
-
-
1942517868
-
Principles: Receptor theory in pharmacology
-
DOI 10.1016/j.tips.2004.02.012, PII S016561470400063X
-
T. Kenakin Principles: receptor theory in pharmacology Trends Pharmacol Sci 26 2004 186 192 (Pubitemid 38519909)
-
(2004)
Trends in Pharmacological Sciences
, vol.25
, Issue.4
, pp. 186-192
-
-
Kenakin, T.1
-
61
-
-
30444461377
-
The receptor concept; Pharmacology's big idea
-
H.P. Rang The receptor concept; pharmacology's big idea Br J Pharmacol 147 2006 S9 S16
-
(2006)
Br J Pharmacol
, vol.147
-
-
Rang, H.P.1
-
62
-
-
0022387153
-
William Withering and the Purple Foxglove: A bicentennial tribute
-
J.M. Norman William Withering and the Purple Foxglove: a bicentennial tribute J. Clin Pharmacol 25 1985 479 483
-
(1985)
J. Clin Pharmacol
, vol.25
, pp. 479-483
-
-
Norman, J.M.1
-
63
-
-
0037784909
-
From elective affinities to chemical equilibria: Berthollet's law of mass action
-
F.L. Holmes From elective affinities to chemical equilibria: Berthollet's law of mass action Chymia 8 1962 105 147
-
(1962)
Chymia
, vol.8
, pp. 105-147
-
-
Holmes, F.L.1
-
64
-
-
3843112035
-
Guldberg and Waage and the law of mass action
-
E.W. Lund Guldberg and Waage and the law of mass action J Chem Educ 42 1965 548 550
-
(1965)
J Chem Educ
, vol.42
, pp. 548-550
-
-
Lund, E.W.1
-
65
-
-
84892364422
-
Quantitative versus qualitative data: The numerical dimensions of drug action
-
D.B. Bylund, and M. Toews Quantitative versus qualitative data: the numerical dimensions of drug action Biochem Pharmacol 87 2014 25 39
-
(2014)
Biochem Pharmacol
, vol.87
, pp. 25-39
-
-
Bylund, D.B.1
Toews, M.2
-
66
-
-
84892367339
-
Defining and characterizing drug/compound function
-
T. Kenakin, and M. Williams Defining and characterizing drug/compound function Biochem Pharmacol 87 2014 40 63
-
(2014)
Biochem Pharmacol
, vol.87
, pp. 40-63
-
-
Kenakin, T.1
Williams, M.2
-
67
-
-
44049103958
-
Residence time of receptor - Ligand complexes and its effect on biological function
-
DOI 10.1021/bi8002023
-
P.J. Tummino, and R.A. Copeland Residence time of receptor-ligand complexes and its effect on biological function Biochemistry 47 2008 5481 5492 (Pubitemid 351711169)
-
(2008)
Biochemistry
, vol.47
, Issue.20
, pp. 5481-5492
-
-
Tummino, P.J.1
Copeland, R.A.2
-
69
-
-
31844446495
-
Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery
-
DOI 10.1016/j.tips.2005.12.007, PII S0165614705003202
-
R.A. Bond, and A.P. Ijzerman Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery Trends Pharmacol Sci 27 2006 92 96 (Pubitemid 43184030)
-
(2006)
Trends in Pharmacological Sciences
, vol.27
, Issue.2
, pp. 92-96
-
-
Bond, R.A.1
Ijzerman, A.P.2
-
70
-
-
0036490942
-
Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery
-
A. Christopoulos Allosteric binding sites on cell-surface receptors: novel targets for drug discovery Nat Rev Drug Discov 1 2002 198 210 (Pubitemid 37361423)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.3
, pp. 198-210
-
-
Christopoulos, A.1
-
71
-
-
84876266689
-
Allostery in disease and in drug discovery
-
R. Nussinov, and C.J. Tsai Allostery in disease and in drug discovery Cell 153 2013 293 305
-
(2013)
Cell
, vol.153
, pp. 293-305
-
-
Nussinov, R.1
Tsai, C.J.2
-
72
-
-
84875227396
-
Signalling bias in new drug discovery: Detection, quantification and therapeutic impact
-
T. Kenakin, and A. Christopoulos Signalling bias in new drug discovery: detection, quantification and therapeutic impact Nat Rev Drug Discov 12 2013 205 216
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 205-216
-
-
Kenakin, T.1
Christopoulos, A.2
-
73
-
-
33748126226
-
Recent approaches to intracellular delivery of drugs and DNA and organelle targeting
-
DOI 10.1146/annurev.bioeng.8.061505.095735
-
V.P. Torchilin Recent approaches to intracellular delivery of drugs and DNA and organelle targeting Ann Rev Biomed Engineer 8 2006 343 375 (Pubitemid 44314821)
-
(2006)
Annual Review of Biomedical Engineering
, vol.8
, pp. 343-375
-
-
Torchilin, V.P.1
-
74
-
-
84874190353
-
Intracellular drug concentrations
-
C.T. Dollery Intracellular drug concentrations Clin Pharmacol Ther 93 2013 263 266
-
(2013)
Clin Pharmacol Ther
, vol.93
, pp. 263-266
-
-
Dollery, C.T.1
-
77
-
-
0000718043
-
The action of adrenaline and ergotamine on the uterus of the rabbit
-
J.H. Gaddum The action of adrenaline and ergotamine on the uterus of the rabbit J Physiol 61 1926 141 150
-
(1926)
J Physiol
, vol.61
, pp. 141-150
-
-
Gaddum, J.H.1
-
78
-
-
28244497552
-
Drug antagonism and pAx
-
H.O. Schild Drug antagonism and pAx Pharmacol Rev 9 1957 242 246
-
(1957)
Pharmacol Rev
, vol.9
, pp. 242-246
-
-
Schild, H.O.1
-
79
-
-
77049220618
-
Affinity and intrinsic activity in the theory of competitive inhibition
-
E.J. Ariens Affinity and intrinsic activity in the theory of competitive inhibition Arch Int Pharmacodyn Ther 99 1954 32 49
-
(1954)
Arch Int Pharmacodyn Ther
, vol.99
, pp. 32-49
-
-
Ariens, E.J.1
-
80
-
-
84951653316
-
A study of the adrenotropic receptors
-
R.P. Ahlquist A study of the adrenotropic receptors Am J Physiol 155 1948 586 600
-
(1948)
Am J Physiol
, vol.155
, pp. 586-600
-
-
Ahlquist, R.P.1
-
81
-
-
0010673662
-
A modification of receptor theory
-
R.P. Stephenson A modification of receptor theory Br J Pharmacol Chemother 11 1956 379 392
-
(1956)
Br J Pharmacol Chemother
, vol.11
, pp. 379-392
-
-
Stephenson, R.P.1
-
82
-
-
0013866946
-
A general analysis of the receptor-drug interaction
-
D. Mackay A general analysis of the receptor-drug interaction Br J Pharmacol 26 1966 9 16
-
(1966)
Br J Pharmacol
, vol.26
, pp. 9-16
-
-
Mackay, D.1
-
83
-
-
0014299372
-
Pharmacological receptors
-
D.R. Waud Pharmacological receptors Pharmacol Rev 20 1968 49 88
-
(1968)
Pharmacol Rev
, vol.20
, pp. 49-88
-
-
Waud, D.R.1
-
84
-
-
0021058380
-
Operational models of pharmacological agonist
-
J.W. Black, and P. Leff Operational models of pharmacological agonist Proc R Soc Lond [Biol] 220 1983 141 162
-
(1983)
Proc R Soc Lond [Biol]
, vol.220
, pp. 141-162
-
-
Black, J.W.1
Leff, P.2
-
85
-
-
0002859426
-
A theory of drug action based on the rate of drug-receptor combination
-
W.D.M. Paton A theory of drug action based on the rate of drug-receptor combination Proc R Soc Lond B 154 1961 21 69
-
(1961)
Proc R Soc Lond B
, vol.154
, pp. 21-69
-
-
Paton, W.D.M.1
-
86
-
-
33947420477
-
Seven transmembrane receptors-A brief personal retrospective
-
DOI 10.1016/j.bbamem.2006.11.001, PII S0005273606004202
-
R.J. Lefkowitz Seven transmembrane receptors - a brief personal retrospective Biochim Biophys Acta 1768 2007 748 755 (Pubitemid 46452547)
-
(2007)
Biochimica et Biophysica Acta - Biomembranes
, vol.1768
, Issue.4
, pp. 748-755
-
-
Lefkowitz, R.J.1
-
87
-
-
84871791493
-
Making receptors a reality: The 2012 Nobel Prize in Chemistry
-
T.P. Kenakin Making receptors a reality: the 2012 Nobel Prize in Chemistry Trends Pharmacol Sci 34 2013 2 5
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 2-5
-
-
Kenakin, T.P.1
-
88
-
-
0032199006
-
Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists acid of the effects of mutating receptors
-
DOI 10.1038/sj.bjp.0702164
-
D. Colquhoun Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors Br J Pharmacol 125 1998 923 947 (Pubitemid 28495353)
-
(1998)
British Journal of Pharmacology
, vol.125
, Issue.5
, pp. 923-947
-
-
Colquhoun, D.1
-
90
-
-
80053394442
-
The original Michaelis constant: Translation of the 1913 Michaelis-Menten paper. Michaelis L, Menten ML. The kinetics of invertase action
-
R.S. Goody, and K.A. Johnson The original Michaelis constant: translation of the 1913 Michaelis-Menten paper. Michaelis L, Menten ML. The kinetics of invertase action Biochemistry 50 2011 8264 8269
-
(2011)
Biochemistry
, vol.50
, pp. 8264-8269
-
-
Goody, R.S.1
Johnson, K.A.2
-
91
-
-
84861219631
-
Allostery and the Monod-Wyman-Changeux model after 50 years
-
J.-P. Changeux Allostery and the Monod-Wyman-Changeux model after 50 years Ann Rev Biophys 41 2012 103 133
-
(2012)
Ann Rev Biophys
, vol.41
, pp. 103-133
-
-
Changeux, J.-P.1
-
92
-
-
0013863816
-
Comparison of experimental binding data and theoretical models in proteins containing subunits
-
D.E. Koshland Jr., G. Némethy, and D. Filmer Comparison of experimental binding data and theoretical models in proteins containing subunits Biochemistry 5 1966 365 368
-
(1966)
Biochemistry
, vol.5
, pp. 365-368
-
-
Koshland, Jr.D.E.1
Némethy, G.2
Filmer, D.3
-
93
-
-
0019137579
-
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor
-
A. DeLean, J.M. Stadel, and R.J. Lefkowitz A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor J Biol Chem 255 1980 7108 7117 (Pubitemid 11232874)
-
(1980)
Journal of Biological Chemistry
, vol.255
, Issue.15
, pp. 7108-7117
-
-
De Lean, A.1
Stadel, J.M.2
Lefkowitz, R.J.3
-
94
-
-
0029983553
-
The cubic ternary complex receptor-occupancy model II. Understanding apparent affinity
-
DOI 10.1006/jtbi.1996.0015
-
J.M. Weiss, P.H. Morgan, M.W. Lutz, and T.P. Kenakin The cubic ternary complex receptor-occupancy model II. Understanding apparent affinity J Theoret Biol 178 1996 169 182 (Pubitemid 26118846)
-
(1996)
Journal of Theoretical Biology
, vol.178
, Issue.2
, pp. 169-182
-
-
Weiss, J.M.1
Morgan, P.H.2
Lutz, M.W.3
Kenakin, T.P.4
-
96
-
-
84859267371
-
Therapeutic target database update 2012: A resource for facilitating target-oriented drug discovery
-
F. Zhu, Z. Shi, C. Qin, L. Tao, X. Liu, and F. Xu et al. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery Nucleic Acids Res 40 2012 D1128 D1136
-
(2012)
Nucleic Acids Res
, vol.40
-
-
Zhu, F.1
Shi, Z.2
Qin, C.3
Tao, L.4
Liu, X.5
Xu, F.6
-
97
-
-
28244486354
-
On the reaction of cells and nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari
-
J.N. Langley On the reaction of cells and nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari J Physiol 33 1905 374 413
-
(1905)
J Physiol
, vol.33
, pp. 374-413
-
-
Langley, J.N.1
-
98
-
-
0029812311
-
The classification of seven transmembrane receptors in recombinant expression systems
-
T.P. Kenakin The classification of seven transmembrane receptors in recombinant expression systems Pharmacol Rev 48 1996 413 463
-
(1996)
Pharmacol Rev
, vol.48
, pp. 413-463
-
-
Kenakin, T.P.1
-
99
-
-
0036463901
-
Efficacy at G-protein-coupled receptors
-
DOI 10.1038/nrd722
-
T. Kenakin Efficacy at G-protein-coupled receptors Nat Rev Drug Discov 1 2002 103 110 (Pubitemid 41646517)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.2
, pp. 103-110
-
-
Kenakin, T.1
-
100
-
-
84872369895
-
New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review
-
T.P. Kenakin New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review Br J Pharmacol 168 2013 554 575
-
(2013)
Br J Pharmacol
, vol.168
, pp. 554-575
-
-
Kenakin, T.P.1
-
101
-
-
84876890609
-
Supra-physiological efficacy at GPCRs: Superstition or super agonists?
-
C.J. Langmead, and A. Christopoulos Supra-physiological efficacy at GPCRs: superstition or super agonists? Br J Pharmacol 169 2013 353 356
-
(2013)
Br J Pharmacol
, vol.169
, pp. 353-356
-
-
Langmead, C.J.1
Christopoulos, A.2
-
102
-
-
0016139387
-
Membrane receptors
-
P. Cuatrecasas Membrane receptors Ann Rev Biochem 43 1974 169 214
-
(1974)
Ann Rev Biochem
, vol.43
, pp. 169-214
-
-
Cuatrecasas, P.1
-
103
-
-
84881171375
-
Pharmacokinetics and the drug-target residence time concept
-
G. Dahl, and T. Akerud Pharmacokinetics and the drug-target residence time concept Drug Discov Today 18 2013 697 707
-
(2013)
Drug Discov Today
, vol.18
, pp. 697-707
-
-
Dahl, G.1
Akerud, T.2
-
104
-
-
0347627709
-
Constitutive Activity and Inverse Agonists of G Protein-Coupled Receptors: A Current Perspective
-
DOI 10.1124/mol.64.6.1271
-
G. Milligan Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective Mol Pharmacol 64 2003 1271 1276 (Pubitemid 37532215)
-
(2003)
Molecular Pharmacology
, vol.64
, Issue.6
, pp. 1271-1276
-
-
Milligan, G.1
-
106
-
-
84879835462
-
Allosteric transition: A comparison of two models
-
N. Bindslev Allosteric transition: a comparison of two models BMC Pharmacol Toxicol 14 2013 4
-
(2013)
BMC Pharmacol Toxicol
, vol.14
, pp. 4
-
-
Bindslev, N.1
-
107
-
-
0036177114
-
Drug efficacy at G protein-coupled receptors
-
DOI 10.1146/annurev.pharmtox.42.091401.113012
-
T. Kenakin Drug efficacy at G protein-coupled receptors Ann Rev Pharmacol Toxicol 42 2002 349 379 (Pubitemid 34160530)
-
(2002)
Annual Review of Pharmacology and Toxicology
, vol.42
, pp. 349-379
-
-
Kenakin, T.1
-
108
-
-
77952354490
-
Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
-
T. Kenakin, and L.J. Miller Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery Pharmacol Rev 62 2010 265 304
-
(2010)
Pharmacol Rev
, vol.62
, pp. 265-304
-
-
Kenakin, T.1
Miller, L.J.2
-
109
-
-
78149496656
-
The role of conformational ensembles of seven transmembrane receptors in functional selectivity
-
N. Vaidehi, and T. Kenakin The role of conformational ensembles of seven transmembrane receptors in functional selectivity Curr Opin Pharmacol 10 2010 775 781
-
(2010)
Curr Opin Pharmacol
, vol.10
, pp. 775-781
-
-
Vaidehi, N.1
Kenakin, T.2
-
111
-
-
60849127863
-
Physiological and pharmacological implications of beta-arrestin regulation
-
C.L. Schmid, and L.M. Bohn Physiological and pharmacological implications of beta-arrestin regulation Pharmacol Ther 121 2009 285 293
-
(2009)
Pharmacol Ther
, vol.121
, pp. 285-293
-
-
Schmid, C.L.1
Bohn, L.M.2
-
112
-
-
1642292051
-
Desensitization of G protein-coupled receptors and neuronal functions
-
DOI 10.1146/annurev.neuro.27.070203.144206
-
R.R. Gainetdinov, R.T. Premont, L.M. Bohn, R.J. Lefkowitz, and Caron MG: Desensitization of G protein-coupled receptors and neuronal functions Annu Rev Neurosci 27 2004 107 144 (Pubitemid 39050399)
-
(2004)
Annual Review of Neuroscience
, vol.27
, pp. 107-144
-
-
Gainetdinov, R.R.1
Premont, R.T.2
Bohn, L.M.3
Lefkowitz, R.J.4
Caron, M.G.5
-
113
-
-
84855901533
-
Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors
-
E. Reiter, S. Ahn, A.K. Shukla, and R.J. Lefkowitz Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors Ann Rev Pharmacol Toxicol 52 2012 179 197
-
(2012)
Ann Rev Pharmacol Toxicol
, vol.52
, pp. 179-197
-
-
Reiter, E.1
Ahn, S.2
Shukla, A.K.3
Lefkowitz, R.J.4
-
114
-
-
39149098113
-
Receptor downregulation and desensitization enhance the information processing ability of signalling receptors
-
H. Shankaran, H.S. Wiley, and H. Resat Receptor downregulation and desensitization enhance the information processing ability of signalling receptors BMC Syst Biol 1 2007 48
-
(2007)
BMC Syst Biol
, vol.1
, pp. 48
-
-
Shankaran, H.1
Wiley, H.S.2
Resat, H.3
-
115
-
-
84874290339
-
Regulation of μ-opioid receptors: Desensitization, phosphorylation, internalization, and tolerance
-
J.T. Williams, S.L. Ingram, G. Henderson, C. Chavkin, M. Zastrow, and S. Schulz et al. Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance Pharmacol Rev 65 2013 223 254
-
(2013)
Pharmacol Rev
, vol.65
, pp. 223-254
-
-
Williams, J.T.1
Ingram, S.L.2
Henderson, G.3
Chavkin, C.4
Zastrow, M.5
Schulz, S.6
-
116
-
-
38349103412
-
Role of receptor internalization in opioid tolerance and dependence
-
T. Koch, and V. Höllt Role of receptor internalization in opioid tolerance and dependence Pharmacol Ther 117 2008 199 206
-
(2008)
Pharmacol Ther
, vol.117
, pp. 199-206
-
-
Koch, T.1
Höllt, V.2
-
117
-
-
0030760634
-
Dimerization of the δ opioid receptor: Implication for a role in receptor internalization
-
S. Cvejic, and L. Devi Dimerization of the δ opioid receptor: implication for a role in receptor internalization J Biol Chem 272 1997 26969 27064
-
(1997)
J Biol Chem
, vol.272
, pp. 26969-27064
-
-
Cvejic, S.1
Devi, L.2
-
118
-
-
0036174608
-
Dimerization: An emerging concept for G protein-coupled receptor ontogeny and function
-
DOI 10.1146/annurev.pharmtox.42.091701.082314
-
S. Angers, A. Salahpour, and M. Bouvier Dimerization: an emerging concept for G-protein-coupled receptor ontogeny and function Ann Rev Pharmacol Toxicol 42 2002 409 435 (Pubitemid 34160532)
-
(2002)
Annual Review of Pharmacology and Toxicology
, vol.42
, pp. 409-435
-
-
Angers, S.1
Salahpour, A.2
Bouvier, M.3
-
119
-
-
3042663287
-
G protein-coupled receptor dimerization: Function and ligand pharmacology
-
DOI 10.1124/mol.104.000497.
-
G. Milligan G protein-coupled receptor dimerization: function and ligand pharmacology Mol Pharmacol 66 2004 1 7 (Pubitemid 38822080)
-
(2004)
Molecular Pharmacology
, vol.66
, Issue.1
, pp. 1-7
-
-
Milligan, G.1
-
120
-
-
84873926627
-
Chemokine receptor oligomerization and allostery
-
B. Stephens, and T.M. Handel Chemokine receptor oligomerization and allostery Prog Mol Biol Transl Sci 115 2013 375 420
-
(2013)
Prog Mol Biol Transl Sci
, vol.115
, pp. 375-420
-
-
Stephens, B.1
Handel, T.M.2
-
121
-
-
0028104202
-
Regulation of signal transduction and signal diversity by receptor oligomerization
-
DOI 10.1016/0968-0004(94)90130-9
-
M.A. Lemmon, and J. Schlessinger Regulation of signal transduction and signal diversity by receptor oligomerization Trends Biochem Sci 19 1994 459 463 (Pubitemid 24342757)
-
(1994)
Trends in Biochemical Sciences
, vol.19
, Issue.11
, pp. 459-463
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
122
-
-
0037145061
-
Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
-
DOI 10.1016/S0092-8674(02)00966-2
-
J. Schlessinger Ligand-induced, receptor-mediated dimerization and activation of EGF receptor Cell 110 2002 669 672 (Pubitemid 35283957)
-
(2002)
Cell
, vol.110
, Issue.6
, pp. 669-672
-
-
Schlessinger, J.1
-
123
-
-
62649159075
-
Ligand-induced ErbB receptor dimerization
-
M.A. Lemmon Ligand-induced ErbB receptor dimerization Exp Cell Res 315 2009 638 648
-
(2009)
Exp Cell Res
, vol.315
, pp. 638-648
-
-
Lemmon, M.A.1
-
124
-
-
0037085287
-
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways
-
DOI 10.1074/jbc.M102750200
-
A. Nohe, S. Hassel, M. Ehrlich, F. Neubauer, W. Sebald, and Y.I. Henis et al. The mode of Bone Morphogenetic Protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways J Biol Chem 277 2002 5330 5338 (Pubitemid 34968578)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.7
, pp. 5330-5338
-
-
Nohe, A.1
Hassel, S.2
Ehrlich, M.3
Neubauer, F.4
Sebald, W.5
Henis, Y.I.6
Knaus, P.7
-
125
-
-
79952331478
-
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization
-
J.W. Fairman, S.R. Wijerathna, M.F. Ahmad, H. Xu, R. Nakano, and S. Jha et al. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization Nat Struct Mol Biol 18 2011 316 322
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 316-322
-
-
Fairman, J.W.1
Wijerathna, S.R.2
Ahmad, M.F.3
Xu, H.4
Nakano, R.5
Jha, S.6
-
126
-
-
0036320471
-
Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling
-
DOI 10.1091/mbc.01-08-0411
-
X. Yu, K.D. Sharma, T. Takahashi, R. Iwamoto, and E. Mekada Ligand-independent dimer formation of Epidermal Growth Factor Receptor (EGFR) is a step separable from ligand-induced EGFR signaling Mol Biol Cell 13 2002 2547 2557 (Pubitemid 34831354)
-
(2002)
Molecular Biology of the Cell
, vol.13
, Issue.7
, pp. 2547-2557
-
-
Yu, X.1
Sharma, K.D.2
Takahashi, T.3
Iwamoto, R.4
Mekada, E.5
-
127
-
-
0037474238
-
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor
-
DOI 10.1074/jbc.M210140200
-
G.J. Babcock, M. Farzan, and J. Sodroski Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor J Biol Chem 278 2003 3378 3385 (Pubitemid 36801253)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.5
, pp. 3378-3385
-
-
Babcock, G.J.1
Farzan, M.2
Sodroski, J.3
-
128
-
-
84879079845
-
The functional size of GPCRs - Monomers, dimers or tetramers?
-
D. Pétrin, and T.E. Hébert The functional size of GPCRs - monomers, dimers or tetramers? Subcell Biochem 63 2012 67 81
-
(2012)
Subcell Biochem
, vol.63
, pp. 67-81
-
-
Pétrin, D.1
Hébert, T.E.2
-
129
-
-
0024363622
-
Down-regulation of insulin receptors is related to insulin internalization
-
D. Geiger, J.-L. Carpentier, P. Gorden, and L. Orci Down-regulation of insulin receptors is related to insulin internalization Exp Cell Res 185 1989 33 40 (Pubitemid 19284494)
-
(1989)
Experimental Cell Research
, vol.185
, Issue.1
, pp. 33-40
-
-
Geiger, D.1
Carpentier, J.-L.2
Gorden, P.3
Orci, L.4
-
130
-
-
0035101820
-
Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
-
S.S. Ferguson Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling Pharmacol Rev 53 2001 1 24 (Pubitemid 32173106)
-
(2001)
Pharmacological Reviews
, vol.53
, Issue.1
, pp. 1-24
-
-
Ferguson, S.S.G.1
-
131
-
-
33947314576
-
Regulation of receptor trafficking by GRKs and arrestins
-
DOI 10.1146/annurev.physiol.69.022405.154712
-
C.A. Moore, S.K. Milano, and J.L. Benovic Regulation of receptor trafficking by GRKs and arrestins Annu Rev Physiol 69 2007 451 482 (Pubitemid 46457651)
-
(2007)
Annual Review of Physiology
, vol.69
, pp. 451-482
-
-
Moore, C.A.C.1
Milano, S.K.2
Benovic, J.L.3
-
132
-
-
0036341207
-
Signal transduction and endocytosis: Close encounters of many kinds
-
A. Sorkin, and M. von Zastrow Signal transduction and endocytosis: close encounters of many kinds Nat Rev Mol Cell Biol 3 2002 600 614
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 600-614
-
-
Sorkin, A.1
Von Zastrow, M.2
-
133
-
-
84873033099
-
β-Arrestins and G protein-coupled receptor trafficking
-
D.S. Kang, X. Tian, and J.L. Benovic β-Arrestins and G protein-coupled receptor trafficking Methods Enzymol 521 2013 91 108
-
(2013)
Methods Enzymol
, vol.521
, pp. 91-108
-
-
Kang, D.S.1
Tian, X.2
Benovic, J.L.3
-
134
-
-
84894697401
-
The insulin receptor translocates to the nucleus to regulate cell proliferation in liver
-
10.1002/hep.26609
-
M.J. Amaya, A.G. Oliveira, E.S. Guimarães, M.C.F. Casteluber, S.M. Carvalho, and L.M. Andrade et al. The insulin receptor translocates to the nucleus to regulate cell proliferation in liver Heptalogy 2013 10.1002/hep.26609
-
(2013)
Heptalogy
-
-
Amaya, M.J.1
Oliveira, A.G.2
Guimarães, E.S.3
Casteluber, M.C.F.4
Carvalho, S.M.5
Andrade, L.M.6
-
136
-
-
77952669652
-
Associated proteins: The universal toolbox controlling ligand gated ion channel function
-
T. Araud, S. Wonnacott, and D. Bertrand Associated proteins: the universal toolbox controlling ligand gated ion channel function Biochem Pharmacol 80 2010 160 169
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 160-169
-
-
Araud, T.1
Wonnacott, S.2
Bertrand, D.3
-
137
-
-
34447642715
-
The evasive nature of drug efficacy: Implications for drug discovery
-
DOI 10.1016/j.tips.2007.06.005, PII S0165614707001502, Allosterism and Collateral Efficacy
-
S. Galandrin, G. Oligny-Longpre, and M. Bouvier The evasive nature of drug efficacy: implications for drug discovery Trends Pharmacol Sci 28 2007 423 430 (Pubitemid 47087968)
-
(2007)
Trends in Pharmacological Sciences
, vol.28
, Issue.8
, pp. 423-430
-
-
Galandrin, S.1
Oligny-Longpre, G.2
Bouvier, M.3
-
138
-
-
78751498756
-
Functional selectivity and biased receptor signaling
-
T. Kenakin Functional selectivity and biased receptor signaling J Pharmacol Exp Ther 336 2010 296 302
-
(2010)
J Pharmacol Exp Ther
, vol.336
, pp. 296-302
-
-
Kenakin, T.1
-
139
-
-
79952488185
-
Therapeutic potential of β-arrestin and G protein-biased agonists
-
E.J. Whalen, S. Rajagopal, and R.J. Lefkowitz Therapeutic potential of β-arrestin and G protein-biased agonists Trends Mol Med 17 2011 126 139
-
(2011)
Trends Mol Med
, vol.17
, pp. 126-139
-
-
Whalen, E.J.1
Rajagopal, S.2
Lefkowitz, R.J.3
-
141
-
-
84857911676
-
GRK2: Multiple roles beyond G protein-coupled receptor desensitization
-
T. Evron, T.L. Daigle, and M.G. Caron GRK2: multiple roles beyond G protein-coupled receptor desensitization Trends Pharmacol Sci 33 2012 154 164
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 154-164
-
-
Evron, T.1
Daigle, T.L.2
Caron, M.G.3
-
142
-
-
33947424008
-
The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling
-
DOI 10.1016/j.bbamem.2006.09.019, PII S0005273606003774
-
C. Ribas, P. Penela, C. Murga, A. Salcedo, C. García-Hoz, and M. Jurado-Pueyo The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling Biochim Biophys Acta 1768 2007 913 922 (Pubitemid 46452540)
-
(2007)
Biochimica et Biophysica Acta - Biomembranes
, vol.1768
, Issue.4
, pp. 913-922
-
-
Ribas, C.1
Penela, P.2
Murga, C.3
Salcedo, A.4
Garcia-Hoz, C.5
Jurado-Pueyo, M.6
Aymerich, I.7
Mayor Jr., F.8
-
143
-
-
0041353628
-
RGS protein and G protein interactions: A little help from their friends
-
DOI 10.1124/mol.64.3.547
-
J.R. Hepler RGS protein and G protein interactions: a little help from their friends Mol Pharmacol 64 2003 547 549 (Pubitemid 37048556)
-
(2003)
Molecular Pharmacology
, vol.64
, Issue.3
, pp. 547-549
-
-
Hepler, J.R.1
-
144
-
-
23944437743
-
AGS proteins: Receptor-independent activators of G-protein signaling
-
DOI 10.1016/j.tips.2005.07.003, PII S0165614705001756
-
J.B. Blumer, M.J. Cismowski, M. Sato, and S.M. Lanier AGS proteins: receptor-independent activators of G-protein signaling Trends Pharmacol Sci 26 2005 470 476 (Pubitemid 41207879)
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, Issue.9
, pp. 470-476
-
-
Blumer, J.B.1
Cismowski, M.J.2
Sato, M.3
Lanier, S.M.4
-
145
-
-
33847781275
-
Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling
-
DOI 10.1016/j.pharmthera.2006.11.001, PII S0163725806001872
-
J.B. Blumer, A.V. Smrcka, and S.M. Lanier Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling Pharmacol Ther 113 2007 488 506 (Pubitemid 46389413)
-
(2007)
Pharmacology and Therapeutics
, vol.113
, Issue.3
, pp. 488-506
-
-
Blumer, J.B.1
Smrcka, A.V.2
Lanier, S.M.3
-
146
-
-
3142776467
-
Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): Randomised controlled trial
-
DOI 10.1016/S0140-6736(03)13800-7
-
P.A. Poole-Wilson, K. Swedberg, J.G. Cleland, A. Di Lenarda, P. Hanrath, and M. Komajda et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial Lancet 362 2003 7 13 (Pubitemid 36835815)
-
(2003)
Lancet
, vol.362
, Issue.9377
, pp. 7-13
-
-
Poole-Wilson, P.A.1
Swedberg, K.2
Cleland, J.G.F.3
Di Lenarda, A.4
Hanrath, P.5
Komajda, M.6
Lubsen, J.7
Lutiger, B.8
Metra, M.9
Remme, W.J.10
Torp-Pedersen, C.11
Scherhag, A.12
Skene, A.13
-
147
-
-
36749094552
-
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
-
DOI 10.1073/pnas.0707936104
-
J.W. Wisler, S.M. DeWire, E.J. Whalen, J.D. Violin, M.T. Drake, and S. Ahn et al. A unique mechanism of β-blocker action: carvedilol stimulates β-arrestin signaling Proc Natl Acad Sci U S A 104 2007 16657 16662 (Pubitemid 350211072)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.42
, pp. 16657-16662
-
-
Wisler, J.W.1
DeWire, S.M.2
Whalen, E.J.3
Violin, J.D.4
Drake, M.T.5
Ahn, S.6
Shenoy, S.K.7
Lefkowitz, R.J.8
-
148
-
-
33845412884
-
GRKs and arrestins: Regulators of migration and inflammation
-
DOI 10.1189/jlb.0606373
-
A. Vroon, C.J. Heijnen, and A. Kavelaars GRKs and arrestins: regulators of migration and inflammation J Leukoc Biol 80 2006 1214 1221 (Pubitemid 44904958)
-
(2006)
Journal of Leukocyte Biology
, vol.80
, Issue.6
, pp. 1214-1221
-
-
Vroon, A.1
Heijnen, C.J.2
Kavelaars, A.3
-
149
-
-
0001158926
-
A look at receptor efficacy. from the signaling network of the cell to the intramolecular motion of the receptor
-
H.O. Onaran, A. Scheer, S. Cotecchia, and T. Costa A look at receptor efficacy. From the signaling network of the cell to the intramolecular motion of the receptor Handbook Exp Pharmacol 148 2002 217 280
-
(2002)
Handbook Exp Pharmacol
, vol.148
, pp. 217-280
-
-
Onaran, H.O.1
Scheer, A.2
Cotecchia, S.3
Costa, T.4
-
150
-
-
0041353568
-
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5
-
DOI 10.1124/mol.64.3.731
-
J.A. O'Brien, W. Lemaire, T.-B. Chang, R.S.L. Chang, M.A. Jacobson, and S.N. Ha et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 Mol Pharmacol 64 2003 731 740 (Pubitemid 37048578)
-
(2003)
Molecular Pharmacology
, vol.64
, Issue.3
, pp. 731-740
-
-
O'Brien, J.A.1
Lemaire, W.2
Chen, T.-B.3
Chang, R.S.L.4
Jacobson, M.A.5
Ha, S.N.6
Lindsley, C.W.7
Schaffhauser, H.J.8
Sur, C.9
Pettibone, D.J.10
Conn, P.J.11
Williams Jr., D.L.12
-
151
-
-
0033669603
-
Modeling the functional effects of allosteric modulators at pharmacological receptors: An extension of the two-state model of receptor activation
-
D.A. Hall Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation Mol Pharmacol 58 2000 1412 1423
-
(2000)
Mol Pharmacol
, vol.58
, pp. 1412-1423
-
-
Hall, D.A.1
-
152
-
-
0017661950
-
Benzodiazepine receptor: Demonstration in the central nervous system
-
H. Mohler, and T. Okada Benzodiazepine receptor: demonstration in the central nervous system Science 198 1977 849 851 (Pubitemid 8214700)
-
(1977)
Science
, vol.198
, Issue.4319
, pp. 849-851
-
-
Mohler, H.1
Okada, T.2
-
153
-
-
4644268516
-
A agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic
-
DOI 10.1016/j.bcp.2004.06.040, PII S0006295204005374, Six Decades of GABA
-
A agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic Biochem Pharmacol 68 2004 1573 1580 (Pubitemid 39286462)
-
(2004)
Biochemical Pharmacology
, vol.68
, Issue.8
, pp. 1573-1580
-
-
Krogsgaard-Larsen, P.1
Frolund, B.2
Liljefors, T.3
Ebert, B.4
-
154
-
-
0028999957
-
A review of the preclinical pharmacology of tiagabine: A potent and selective anticonvulsant GABA uptake inhibitor
-
P.D. Suzdak, and J.A. Jansen A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor Epilepsia 36 1995 612 626
-
(1995)
Epilepsia
, vol.36
, pp. 612-626
-
-
Suzdak, P.D.1
Jansen, J.A.2
-
155
-
-
0035032316
-
Oligomerisation of G-protein-coupled receptors
-
G. Milligan Oligomerisation of G-protein-coupled receptors J Cell Sci 114 2001 1265 1271 (Pubitemid 32409463)
-
(2001)
Journal of Cell Science
, vol.114
, Issue.7
, pp. 1265-1271
-
-
Milligan, G.1
-
156
-
-
77954674575
-
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
-
B. Bengsch, B. Seigel, M. Ruhl, J. Timm, and M. Kuntz et al. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation PLoS Pathog 6 2010 e1000947
-
(2010)
PLoS Pathog
, vol.6
, pp. 1000947
-
-
Bengsch, B.1
Seigel, B.2
Ruhl, M.3
Timm, J.4
Kuntz, M.5
-
157
-
-
0033946468
-
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
-
DOI 10.1038/76615
-
H. Husi, M.A. Ward, J.S. Choudary, W.P. Blackstock, and S.G.N. Grant Proteomic analysis of NMDA receptor-adhesion protein signaling complexes Nat Neurosci 3 2000 661 669 (Pubitemid 30437200)
-
(2000)
Nature Neuroscience
, vol.3
, Issue.7
, pp. 661-669
-
-
Husi, H.1
Ward, M.A.2
Choudhary, J.S.3
Blackstock, W.P.4
Grant, S.G.N.5
-
159
-
-
0001536516
-
The action of certain esters and ethers of choline, and their relation to muscarine
-
H.H. Dale The action of certain esters and ethers of choline, and their relation to muscarine J Pharm Exp Ther 6 1914 174 190
-
(1914)
J Pharm Exp Ther
, vol.6
, pp. 174-190
-
-
Dale, H.H.1
-
160
-
-
0345490945
-
International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology
-
DOI 10.1124/pr.55.4.4
-
R.R. Neubig, M. Spedding, T. Kenakin, and A. Christopoulos International union of pharmacology committee on receptor nomenclature and drug classification. XXXVIII. Update on terms and symbols in quantitative pharmacology Pharmacol Rev 55 2003 597 606 (Pubitemid 37500521)
-
(2003)
Pharmacological Reviews
, vol.55
, Issue.4
, pp. 597-606
-
-
Neubig, R.R.1
Spedding, M.2
Kenakin, T.3
Christopoulos, A.4
-
161
-
-
70450280652
-
A binding question: The evolution of the receptor concept
-
quoted by Maehle A-H
-
De Jongh DK, quoted by Maehle A-H. A binding question: the evolution of the receptor concept. Endeavour 2009;33:134-9.
-
(2009)
Endeavour
, vol.33
, pp. 134-139
-
-
De Jongh, D.K.1
-
162
-
-
0015857085
-
Adrenergic receptors: A personal and practical view
-
R.P. Ahlquist Adrenergic receptors: a personal and practical view Persp Biol Med 1973 119 122
-
(1973)
Persp Biol Med
, pp. 119-122
-
-
Ahlquist, R.P.1
-
166
-
-
30444450793
-
The cholinergic receptor
-
P.G. Waser The cholinergic receptor J Pharm Pharmacol 12 1960 577 594
-
(1960)
J Pharm Pharmacol
, vol.12
, pp. 577-594
-
-
Waser, P.G.1
-
167
-
-
0015231923
-
Isolation of the cholinergic receptor protein of Torpedo electric tissue
-
R. Miledi, P. Molinoff, and L.T. Potter Isolation of the cholinergic receptor protein of Torpedo electric tissue Nature 229 1971 554 557
-
(1971)
Nature
, vol.229
, pp. 554-557
-
-
Miledi, R.1
Molinoff, P.2
Potter, L.T.3
-
169
-
-
0017116648
-
The large scale preparation of rhodopsin
-
P.A. Hargrave The large scale preparation of rhodopsin Vision Res 16 1976 1013 1014
-
(1976)
Vision Res
, vol.16
, pp. 1013-1014
-
-
Hargrave, P.A.1
-
172
-
-
0021160160
-
2-adrenergic receptor: Purification and characterization
-
DOI 10.1021/bi00315a002
-
J.L. Benovic, R.G. Shorr, M.G. Caron, and R.J. Lefkowitz The mammalian β2-adrenergic receptor: purification and characterization Biochemistry 23 1984 4510 4518 (Pubitemid 14012267)
-
(1984)
Biochemistry
, vol.23
, Issue.20
, pp. 4510-4518
-
-
Benovic, J.L.1
Shorr, R.G.L.2
Caron, M.G.3
Lefkowitz, R.J.4
-
173
-
-
0017073993
-
Ahlquist and the development of beta-adrenoceptor antagonists
-
J.W. Black Ahlquist and the development of beta-adrenoceptor antagonists Postgrad Med J 52 Suppl. 4 1976 11 13
-
(1976)
Postgrad Med J
, vol.52
, Issue.SUPPL. 4
, pp. 11-13
-
-
Black, J.W.1
-
174
-
-
70450280652
-
A binding question: The evolution of the receptor concept
-
A.-H. Maehle A binding question: the evolution of the receptor concept Endeavour 33 2009 134 139
-
(2009)
Endeavour
, vol.33
, pp. 134-139
-
-
Maehle, A.-H.1
-
175
-
-
0000380542
-
Immunoassay of endogenous plasma insulin in man
-
R.S. Yalow, and S.A. Berson Immunoassay of endogenous plasma insulin in man J Clin Invest 39 1960 1157 1175
-
(1960)
J Clin Invest
, vol.39
, pp. 1157-1175
-
-
Yalow, R.S.1
Berson, S.A.2
-
176
-
-
0005949052
-
Binding of hormone to tissue: The first step in polypeptide hormone action
-
I. Pastan, J. Roth, and V. Macchia Binding of hormone to tissue: the first step in polypeptide hormone action Proc Natl Acad Sci U S A 56 1966 1802 1809
-
(1966)
Proc Natl Acad Sci U S A
, vol.56
, pp. 1802-1809
-
-
Pastan, I.1
Roth, J.2
Macchia, V.3
-
177
-
-
0014935409
-
Radioreceptor assay of adrenocorticotropic hormone: New approach to assay of polypeptide hormones in plasma
-
R.J. Lefkowitz, J. Roth, and I. Pastan Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma Science 170 1970 633 635
-
(1970)
Science
, vol.170
, pp. 633-635
-
-
Lefkowitz, R.J.1
Roth, J.2
Pastan, I.3
-
178
-
-
0015071405
-
Insulin-receptor interactions in adipose tissue cells: Direct measurement and properties
-
P. Cuatrecasas Insulin-receptor interactions in adipose tissue cells: direct measurement and properties Proc Natl Acad Sci U S A 68 1971 1264 1268
-
(1971)
Proc Natl Acad Sci U S A
, vol.68
, pp. 1264-1268
-
-
Cuatrecasas, P.1
-
179
-
-
0015407489
-
Identification of the cardiac beta-adrenergic receptor protein: Solubilization and purification by affinity chromatography
-
R.J. Lefkowitz, E. Haber, and D. O'Hara Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography Proc Natl Acad Sci U S A 69 1972 2828 2832
-
(1972)
Proc Natl Acad Sci U S A
, vol.69
, pp. 2828-2832
-
-
Lefkowitz, R.J.1
Haber, E.2
O'Hara, D.3
-
180
-
-
0015918260
-
Opiate receptor: Demonstration in nervous tissue
-
C.D. Pert, and S.H. Snyder Opiate receptor: demonstration in nervous tissue Science 179 1973 1011 1014
-
(1973)
Science
, vol.179
, pp. 1011-1014
-
-
Pert, C.D.1
Snyder, S.H.2
-
183
-
-
84875469202
-
Recent developments in the study of opioid receptors
-
B.M. Cox Recent developments in the study of opioid receptors Mol Pharmacol 83 2013 723 728
-
(2013)
Mol Pharmacol
, vol.83
, pp. 723-728
-
-
Cox, B.M.1
-
184
-
-
0027138551
-
Radioligand binding methods: Practical guide and tips
-
D.B. Bylund, and M.L. Toews Radioligand binding methods: practical guide and tips Am J Physiol Lung Physiol 265 1993 L421 L429
-
(1993)
Am J Physiol Lung Physiol
, vol.265
-
-
Bylund, D.B.1
Toews, M.L.2
-
186
-
-
0023160677
-
3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: A selective, high-affinity ligand for N-methyl-D-aspartate receptors
-
3H] 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: a selective, high-affinity ligand for N-methyl-d-aspartate receptors J Pharmacol Exp Ther 240 1987 778 784 (Pubitemid 17043574)
-
(1987)
Journal of Pharmacology and Experimental Therapeutics
, vol.240
, Issue.3
, pp. 778-784
-
-
Murphy, D.E.1
Schneider, J.2
Boehm, C.3
-
187
-
-
0017255979
-
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
-
I. Creese, D.R. Burt, and S.H. Snyder Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs Science 192 1976 481 483
-
(1976)
Science
, vol.192
, pp. 481-483
-
-
Creese, I.1
Burt, D.R.2
Snyder, S.H.3
-
188
-
-
0016697198
-
Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions
-
S.J. Enna, and S.H. Snyder Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions Brain Res 100 1975 81 97
-
(1975)
Brain Res
, vol.100
, pp. 81-97
-
-
Enna, S.J.1
Snyder, S.H.2
-
189
-
-
0040209829
-
Strychnine binding associated with glycine receptors of the central nervous system
-
A.B. Young, and S.H. Snyder Strychnine binding associated with glycine receptors of the central nervous system Proc Natl Acad Sci U S A 70 1973 2832 2836
-
(1973)
Proc Natl Acad Sci U S A
, vol.70
, pp. 2832-2836
-
-
Young, A.B.1
Snyder, S.H.2
-
191
-
-
0016695856
-
Stereospecific binding of d-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors
-
J.P. Bennett Jr., and S.H. Snyder Stereospecific binding of d-lysergic acid diethylamide (LSD) to brain membranes: relationship to serotonin receptors Brain Res 94 1975 523 544
-
(1975)
Brain Res
, vol.94
, pp. 523-544
-
-
Bennett, Jr.J.P.1
Snyder, S.H.2
-
193
-
-
0017165533
-
Beta adrenergic receptor binding in membrane preparations from mammalian brain
-
D.B. Bylund, and S.H. Snyder Beta adrenergic receptor binding in membrane preparations from mammalian brain Mol Pharmacol 12 1976 568 580
-
(1976)
Mol Pharmacol
, vol.12
, pp. 568-580
-
-
Bylund, D.B.1
Snyder, S.H.2
-
194
-
-
0344656172
-
Catecholamine binding to the beta-adrenergic receptor
-
R.J. Lefkowitz, and L.T. Williams Catecholamine binding to the beta-adrenergic receptor Proc Natl Acad Sci U S A 74 1977 515 519
-
(1977)
Proc Natl Acad Sci U S A
, vol.74
, pp. 515-519
-
-
Lefkowitz, R.J.1
Williams, L.T.2
-
195
-
-
0019462450
-
Dopamine receptors, neuroleptics and schizophrenia
-
S.H. Snyder Dopamine receptors, neuroleptics and schizophrenia Am J Psychiatr 138 1981 460 464
-
(1981)
Am J Psychiatr
, vol.138
, pp. 460-464
-
-
Snyder, S.H.1
-
196
-
-
84858121231
-
Tools for GPCR drug discovery
-
R. Zhang, and X. Xie Tools for GPCR drug discovery Acta Pharmacol Sin 33 2012 372 384
-
(2012)
Acta Pharmacol Sin
, vol.33
, pp. 372-384
-
-
Zhang, R.1
Xie, X.2
-
197
-
-
79955768829
-
Remote control of neuronal signaling
-
S.C. Rogan, and B.L. Roth Remote control of neuronal signaling Pharmacol Rev 63 2011 291 315
-
(2011)
Pharmacol Rev
, vol.63
, pp. 291-315
-
-
Rogan, S.C.1
Roth, B.L.2
-
198
-
-
84884655331
-
Targeting neurons and photons for optogenetics
-
A.M. Packer, B. Roska, and M. Häusser Targeting neurons and photons for optogenetics Nat Neurosci 16 2013 805 815
-
(2013)
Nat Neurosci
, vol.16
, pp. 805-815
-
-
Packer, A.M.1
Roska, B.2
Häusser, M.3
-
202
-
-
0020660428
-
Increased serotonin-2 binding sites in frontal cortex of suicide victims
-
M. Stanley, and J.J. Mann Increased serotonin-2 binding sites in frontal cortex of suicide victims Lancet 1 1983 214 216 (Pubitemid 13171106)
-
(1983)
Lancet
, vol.1
, Issue.8318
, pp. 214-216
-
-
Stanley, M.1
Mann, J.J.2
-
203
-
-
0018606699
-
Neurotransmitter receptors in frontal cortex of schizophrenics
-
J.P. Bennett Jr., S.J. Enna, D.B. Bylund, J.C. Gillin, R.J. Wyatt, and S.H. Snyder Neurotransmitter receptors in frontal cortex of schizophrenics Arch Gen Psychiatry 36 1979 927 934 (Pubitemid 10121036)
-
(1979)
Archives of General Psychiatry
, vol.36
, Issue.9
, pp. 927-934
-
-
Bennett Jr., J.P.1
Enna, S.J.2
Bylund, D.B.3
-
204
-
-
0023641322
-
Quantitative autoradiography of hippocampal GABA(B) and GABA(A) receptor changes in Alzheimer's disease
-
DOI 10.1016/0304-3940(87)90264-3
-
A receptor changes in Alzheimer's disease Neurosci Lett 82 1987 246 252 (Pubitemid 17159134)
-
(1987)
Neuroscience Letters
, vol.82
, Issue.3
, pp. 246-252
-
-
Chu, D.C.M.1
Penney Jr., J.B.2
Young, A.B.3
-
205
-
-
0035214283
-
1 receptor antagonist losartan
-
S.D. Katugampola, and A.P. Davenport Thromboxane receptor density is increased in human cardiovascular disease with evidence for inhibition at therapeutic concentrations by the AT1 receptor antagonist losartan Br J Pharmacol 134 2001 1385 1392 (Pubitemid 33131888)
-
(2001)
British Journal of Pharmacology
, vol.134
, Issue.7
, pp. 1385-1392
-
-
Katugampola, S.D.1
Davenport, A.P.2
-
206
-
-
0030610319
-
2+ channel/ryanodine receptor: Modulation by endogenous effectors, drugs and disease states
-
2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states Pharmacol Rev 49 1997 1 52
-
(1997)
Pharmacol Rev
, vol.49
, pp. 1-52
-
-
Zucchi, R.1
Ronca-Testoni, S.2
-
207
-
-
0030992061
-
Binding properties of glutamate receptors in streptozotocin-induced diabetes in rats
-
J. Gagné, M. Milot, S. Gélinas, A. Lahsaïni, F. Trudeau, and M.G. Martinoli et al. Binding properties of glutamate receptors in streptozotocin-induced diabetes in rats Diabetes 46 1997 841 846 (Pubitemid 27188262)
-
(1997)
Diabetes
, vol.46
, Issue.5
, pp. 841-846
-
-
Gagne, J.1
Milot, M.2
Gelinas, S.3
Lahsaini, A.4
Trudeau, F.5
Martinoli, M.-G.6
Massicotte, G.7
-
208
-
-
0016429728
-
Binding of insulin and other hormones to non-receptor materials: Saturability, specificity and apparent "negative cooperativity"
-
P. Cuatrecasas, and M.D. Hollenberg Binding of insulin and other hormones to non-receptor materials: saturability, specificity and apparent "negative cooperativity" Biochem Biophys Res Commun 1975 31 41
-
(1975)
Biochem Biophys Res Commun
, pp. 31-41
-
-
Cuatrecasas, P.1
Hollenberg, M.D.2
-
210
-
-
4644271084
-
Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
-
B.L. Roth, D.J. Sheffler, and W.K. Kroeze Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia Nat Rev Drug Discov 3 2004 353 359 (Pubitemid 38499762)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.4
, pp. 353-359
-
-
Roth, B.L.1
Sheffer, D.J.2
Kroeze, W.K.3
-
211
-
-
84858442357
-
Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: A reassessment in vitro and in vivo
-
M. Humbert-Claude, E. Davenas, F. Gbahou, L. Vincent, and J.-M. Arrang Involvement of histamine receptors in the atypical antipsychotic profile of clozapine: a reassessment in vitro and in vivo Psychopharmacology 220 2012 225 241
-
(2012)
Psychopharmacology
, vol.220
, pp. 225-241
-
-
Humbert-Claude, M.1
Davenas, E.2
Gbahou, F.3
Vincent, L.4
Arrang, J.-M.5
-
212
-
-
84865339859
-
Immunomodulatory effects of clozapine and their clinical implications: What have we learned so far?
-
R. Røge, B.K. Møller, C.R. Andersen, C.U. Correll, and J. Nielsen Immunomodulatory effects of clozapine and their clinical implications: what have we learned so far? Schizophr Res 140 2012 204 213
-
(2012)
Schizophr Res
, vol.140
, pp. 204-213
-
-
Røge, R.1
Møller, B.K.2
Andersen, C.R.3
Correll, C.U.4
Nielsen, J.5
-
214
-
-
0021263088
-
Classification of drugs according to receptor binding profiles
-
A. Closse, W. Frick, A. Dravid, G. Bolliger, D. Hauser, and A. Sauter et al. Classification of drugs according to receptor binding profiles Naunyn-Schmiedeberg's Arch Pharmacol 327 1984 95 101 (Pubitemid 14066534)
-
(1984)
Naunyn-Schmiedeberg's Archives of Pharmacology
, vol.327
, Issue.2
, pp. 95-101
-
-
Closse, A.1
Frick, W.2
Dravid, A.3
-
215
-
-
0037365125
-
Neighborhood behavior of in silico structural spaces with respect to in vitro activity spaces - A novel understanding of the molecular similarity principle in the context of multiple receptor binding profiles
-
D. Horvath, and C. Jeandenans Neighborhood behavior of in silico structural spaces with respect to in vitro activity spaces - a novel understanding of the molecular similarity principle in the context of multiple receptor binding profiles J Chem Inf Comput Sci 43 2003 680 690
-
(2003)
J Chem Inf Comput Sci
, vol.43
, pp. 680-690
-
-
Horvath, D.1
Jeandenans, C.2
-
216
-
-
84870774465
-
Reducing safety-related drug attrition: The use of in vitro pharmacological profiling
-
J. Bowes, A.J. Brown, J. Hamon, W. Jarolimek, A. Sridhar, and G. Waldron et al. Reducing safety-related drug attrition: the use of in vitro pharmacological profiling Nat Rev Drug Discov 11 2012 909 922
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 909-922
-
-
Bowes, J.1
Brown, A.J.2
Hamon, J.3
Jarolimek, W.4
Sridhar, A.5
Waldron, G.6
-
217
-
-
0020041684
-
Antiemetics: Neurotransmitter receptor binding predicts therapeutic actions
-
S.J. Peroutka, and S.H. Snyder Antiemetics: neurotransmitter receptor binding predicts therapeutic actions Lancet 319 1982 658 659 (Pubitemid 12179938)
-
(1982)
Lancet
, vol.1
, Issue.8273
, pp. 658-659
-
-
Peroutka, S.J.1
Snyder, S.H.2
-
218
-
-
84880035894
-
A history of the role of the hERG channel in cardiac risk assessment
-
D. Rampe, and A.M. Brown A history of the role of the hERG channel in cardiac risk assessment J Pharmacol Toxicoll Methods 68 2013 13 22
-
(2013)
J Pharmacol Toxicoll Methods
, vol.68
, pp. 13-22
-
-
Rampe, D.1
Brown, A.M.2
-
219
-
-
34249774271
-
High-throughput screening goes to school
-
DOI 10.1038/nmeth0607-523, PII NMETH0607-523
-
A. Dove High-throughput screening goes to school Nat Methods 4 2007 523 532 (Pubitemid 46852079)
-
(2007)
Nature Methods
, vol.4
, Issue.6
, pp. 523-532
-
-
Dove, A.1
-
220
-
-
33745846820
-
Screening the receptorome: An efficient approach for drug discovery and target validation
-
DOI 10.1016/j.drudis.2006.06.012, PII S1359644606002339
-
R.T. Strachan, G. Ferrara, and B.L. Roth Screening the receptorome: an efficient approach for drug discovery and target validation Drug Discov Today 11 2006 708 716 (Pubitemid 44038633)
-
(2006)
Drug Discovery Today
, vol.11
, Issue.15-16
, pp. 708-716
-
-
Strachan, R.T.1
Ferrara, G.2
Roth, B.L.3
-
221
-
-
0027318246
-
The role of receptor binding in drug discovery
-
P.M. Sweetnam, L. Caldwell, J. Lancaster, C. Bauer Jr., B. McMillan, and W.J. Kinnier et al. The role of receptor binding in drug discovery J Nat Prod 56 1993 441 455 (Pubitemid 23129606)
-
(1993)
Journal of Natural Products (Lloydia)
, vol.56
, Issue.4
, pp. 441-455
-
-
Sweetnam, P.M.1
Caldwell, L.2
Lancaster, J.3
Bauer, J.C.4
McMillan, B.5
Kinnier, W.J.6
Price, C.H.7
-
222
-
-
77957761048
-
Compound collection enhancement and paradigms for high-throughput screening - An update
-
S.W. Duric, I. Akritopoulou-Zanze, P.B. Cox, and S. Galasinski Compound collection enhancement and paradigms for high-throughput screening - an update Ann Rep Med Chem 45 2010 409 428
-
(2010)
Ann Rep Med Chem
, vol.45
, pp. 409-428
-
-
Duric, S.W.1
Akritopoulou-Zanze, I.2
Cox, P.B.3
Galasinski, S.4
-
223
-
-
79952131874
-
Impact of high-throughput screening in biomedical research
-
R. Macarron, M.N. Banks, D. Bojanic, D.J. Burns, D.A. Cirovic, and T. Garyantes et al. Impact of high-throughput screening in biomedical research Nat Rev Drug Discov 10 2011 188 195
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 188-195
-
-
Macarron, R.1
Banks, M.N.2
Bojanic, D.3
Burns, D.J.4
Cirovic, D.A.5
Garyantes, T.6
-
224
-
-
0042707768
-
Screening for content - The evolution of high throughput
-
DOI 10.1038/nbt0803-859
-
A. Dove Screening for content - the evolution of high throughput Nat Biotechnol 21 2003 859 864 (Pubitemid 36936186)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.8
, pp. 859-864
-
-
Dove, A.1
-
225
-
-
17944366722
-
Complex gel permeation assays for screening combinatorial libraries
-
DOI 10.1089/108705701753200527
-
M.E. Schurdak, M.J. Voorbach, L. Gao, X. Cheng, K.M. Comess, and S.M. Rottinghaus et al. Complex gel permeation assays for screening combinatorial libraries J Biomol Screen 6 2001 313 323 (Pubitemid 33027498)
-
(2001)
Journal of Biomolecular Screening
, vol.6
, Issue.5
, pp. 313-323
-
-
Schurdak, M.E.1
Voorbach, M.J.2
Gao, L.3
Cheng, X.4
Comess, K.M.5
Rottinghaus, S.M.6
Warrior, U.7
Truong, H.N.8
Burns, D.J.9
Beutel, B.A.10
-
226
-
-
77749270677
-
Ultra high-throughput screening in drop-based microfluidics for directed evolution
-
J.J. Agrestia, E. Antipov, A.R. Abate, K. Ahn, A.C. Rowat, and J.-C. Barete et al. Ultra high-throughput screening in drop-based microfluidics for directed evolution Proc Natl Acad Sci U S A 107 2010 4004 4009
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 4004-4009
-
-
Agrestia, J.J.1
Antipov, E.2
Abate, A.R.3
Ahn, K.4
Rowat, A.C.5
Barete, J.-C.6
-
227
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
DOI 10.1016/S0169-409X(00)00129-0, PII S0169409X00001290
-
C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv Drug Deliv Rev 46 2001 3 26 (Pubitemid 33653411)
-
(2000)
Advanced Drug Delivery Reviews
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
228
-
-
84861490509
-
Modern phenotypic drug discovery is a viable, neoclassic pharma strategy
-
J.A. Lee, M.T. Uhlik, C.M. Moxham, D. Tomandl, and D.J. Sall Modern phenotypic drug discovery is a viable, neoclassic pharma strategy J Med Chem 55 2012 4527 4538
-
(2012)
J Med Chem
, vol.55
, pp. 4527-4538
-
-
Lee, J.A.1
Uhlik, M.T.2
Moxham, C.M.3
Tomandl, D.4
Sall, D.J.5
-
229
-
-
42149193214
-
High-throughput electrophysiology: An emerging paradigm for ion-channel screening and physiology
-
J. Dunlop, M. Bowlby, R. Peri, D. Vasilyev, and R. Arias High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology Nat Rev Drug Discov 7 2008 358 368
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 358-368
-
-
Dunlop, J.1
Bowlby, M.2
Peri, R.3
Vasilyev, D.4
Arias, R.5
-
230
-
-
80053595693
-
A system for performing high throughput assays of synaptic function
-
C.M. Hempel, M. Sivula, J.M. Levenson, D.M. Rose, and B. Li et al. A system for performing high throughput assays of synaptic function PLoS ONE 6 2011 e25999
-
(2011)
PLoS ONE
, vol.6
, pp. 25999
-
-
Hempel, C.M.1
Sivula, M.2
Levenson, J.M.3
Rose, D.M.4
Li, B.5
-
231
-
-
0021212048
-
Reconstitution of a hormone-sensitive adenylate cyclase system. The pure β-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit
-
R.A. Cerione, D.R. Sibley, J. Codina, J.L. Benovic, J. Winslow, and E.J. Neer et al. Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit J Biol Chem 259 1984 9979 9982 (Pubitemid 14067662)
-
(1984)
Journal of Biological Chemistry
, vol.259
, Issue.16
, pp. 9979-9982
-
-
Cerione, R.A.1
Sibley, D.R.2
Codina, J.3
-
234
-
-
0020338409
-
Identification of a cDNA clone coding for the acetylcholine binding subunit of Torpedo marmorata acetylcholine receptor
-
J. Giraudat, A. Devillers-Thiery, C. Auffray, F. Rougeon, and J.-P. Changeaux Identification of a cDNA clone coding for the acetylcholine binding subunit of Torpedo marmorata acetylcholine receptor EMBO J 1 1982 713 717
-
(1982)
EMBO J
, vol.1
, pp. 713-717
-
-
Giraudat, J.1
Devillers-Thiery, A.2
Auffray, C.3
Rougeon, F.4
Changeaux, J.-P.5
-
236
-
-
0022485749
-
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
-
R.A.F. Dixon, B.K. Kobilka, D.J. Strader, J.L. Benovic, H.G. Dohlman, and T. Frielle et al. Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin Nature 321 1986 75 79 (Pubitemid 16080889)
-
(1986)
Nature
, vol.321
, Issue.6065
, pp. 75-79
-
-
Dixon, R.A.F.1
Kobilka, B.K.2
Strader, D.J.3
-
237
-
-
33751502151
-
International union of pharmacology. LXVI. Orphan nuclear receptors
-
DOI 10.1124/pr.58.4.10
-
G. Benoit, A. Cooney, V. Giguere, H. Ingraham, M. Lazar, and G. Muscat et al. International union of pharmacology. LXVI. Orphan nuclear receptors Pharmacol Rev 58 2006 798 836 (Pubitemid 44833747)
-
(2006)
Pharmacological Reviews
, vol.58
, Issue.4
, pp. 798-836
-
-
Benoit, G.1
Cooney, A.2
Giguere, V.3
Ingraham, H.4
Lazar, M.5
Muscat, G.6
Perlmann, T.7
Renaud, J.-P.8
Schwabe, J.9
Sladek, F.10
Tsai, M.-J.11
Laudet, V.12
-
238
-
-
0029797712
-
1-binding site
-
DOI 10.1073/pnas.93.15.8072
-
M. Hanner, F.F. Moebius, A. Flandorfer, H.G. Knaus, J. Striessnig, and E. Kempner et al. Purification, molecular cloning, and expression of the mammalian sigma 1-binding site Proc Natl Acad Sci U S A 93 1996 8072 8077 (Pubitemid 26277167)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.15
, pp. 8072-8077
-
-
Hanner, M.1
Moebius, F.F.2
Flandorfer, A.3
Knaus, H.-G.4
Striessnig, J.5
Kempner, E.6
Glossmann, H.7
-
239
-
-
0031892683
-
Cloning and functional characterization of a σ receptor from rat brain
-
P. Seth, Y.-J. Hui, W. Li, W. Huang, F.H. Leibach, and V. Ganapathy Cloning and functional characterization of a sigma receptor from rat brain J Neurochem 70 1998 922 931 (Pubitemid 28113624)
-
(1998)
Journal of Neurochemistry
, vol.70
, Issue.3
, pp. 922-931
-
-
Seth, P.1
Fei, Y.-J.2
Li, H.W.3
Huang, W.4
Leibach, F.H.5
Ganapathy, V.6
-
240
-
-
70349116879
-
The pharmacology of sigma-1 receptors
-
T. Maurice, and T.P. Su The pharmacology of sigma-1 receptors Pharmacol Ther 124 2009 195 206
-
(2009)
Pharmacol Ther
, vol.124
, pp. 195-206
-
-
Maurice, T.1
Su, T.P.2
-
241
-
-
79960099287
-
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site
-
J. Xu, C. Zeng, W. Chu, F. Pan, J.M. Rothfuss, and F. Zhang Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site Nat Commun 2 2011 380
-
(2011)
Nat Commun
, vol.2
, pp. 380
-
-
Xu, J.1
Zeng, C.2
Chu, W.3
Pan, F.4
Rothfuss, J.M.5
Zhang, F.6
-
242
-
-
0029936826
-
2 receptor
-
2 receptor J Pharmacol Exp Ther 276 1996 289 297 (Pubitemid 26150970)
-
(1996)
Journal of Pharmacology and Experimental Therapeutics
, vol.276
, Issue.1
, pp. 289-297
-
-
Gopalakrishnan, M.1
Monteggia, L.M.2
Anderson, D.J.3
Molinari, E.J.4
Piattoni-Kaplan, M.5
Donnelly-Roberts, D.6
Arneric, S.P.7
Sullivan, J.P.8
-
243
-
-
84878371294
-
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: Recommendations for new pairings with cognate ligands
-
A.O. Davenport, S.H.P. Alexander, J.L. Sharman, A.J. Pawson, H.E. Benson, and A.E. Monaghan International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands Pharmacol Rev 65 2013 967 986
-
(2013)
Pharmacol Rev
, vol.65
, pp. 967-986
-
-
Davenport, A.O.1
Alexander, S.H.P.2
Sharman, J.L.3
Pawson, A.J.4
Benson, H.E.5
Monaghan, A.E.6
-
244
-
-
84867116699
-
Orphan GPCRs and neuromodulation
-
O. Civelli Orphan GPCRs and neuromodulation Neuron 76 2012 12 21
-
(2012)
Neuron
, vol.76
, pp. 12-21
-
-
Civelli, O.1
-
245
-
-
84872243626
-
G protein-coupled receptor deorphanizations
-
O. Civelli, R.K. Reinscheid, Y. Zhang, Z. Wang, R. Fredriksson, and H.B. Schiöth G protein-coupled receptor deorphanizations Ann Rev Pharmacol Toxicol 53 2013 127 146
-
(2013)
Ann Rev Pharmacol Toxicol
, vol.53
, pp. 127-146
-
-
Civelli, O.1
Reinscheid, R.K.2
Zhang, Y.3
Wang, Z.4
Fredriksson, R.5
Schiöth, H.B.6
-
246
-
-
0038024615
-
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
-
DOI 10.1124/mol.63.6.1256
-
R. Fredriksson, M.C. Lagerström, L.-G. Lundin, and H.B. Schiöth The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints Mol Pharmacol 63 2003 1256 1272 (Pubitemid 36627220)
-
(2003)
Molecular Pharmacology
, vol.63
, Issue.6
, pp. 1256-1272
-
-
Fredriksson, R.1
Lagerstrom, M.C.2
Lundin, L.-G.3
Schioth, H.B.4
-
247
-
-
42149181885
-
Structural diversity of G protein-coupled receptors and significance for drug discovery
-
M.C. Lagerstrom, and H.B. Schioth Structural diversity of G protein-coupled receptors and significance for drug discovery Nat Rev Drug Discov 7 2008 339 357
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 339-357
-
-
Lagerstrom, M.C.1
Schioth, H.B.2
-
248
-
-
4043120579
-
Receptor mutagenesis strategies for examination of structure-function relationships
-
M. Blomenröhr, H.F. Vischer, and J. Bogerd Receptor mutagenesis strategies for examination of structure-function relationships Methods Mol Biol 259 2004 307 322
-
(2004)
Methods Mol Biol
, vol.259
, pp. 307-322
-
-
Blomenröhr, M.1
Vischer, H.F.2
Bogerd, J.3
-
249
-
-
0023889603
-
Chimeric alpha 2, beta 2-adrenergic receptors: Delineation of domains involved in effector coupling and ligand binding specificity
-
B.K. Kobilka, T.S. Kobilka, K. Daniel, J.W. Regan, M.G. Caron, and R.J. Lefkowitz Chimeric alpha 2, beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity Science 240 1988 1310 1316
-
(1988)
Science
, vol.240
, pp. 1310-1316
-
-
Kobilka, B.K.1
Kobilka, T.S.2
Daniel, K.3
Regan, J.W.4
Caron, M.G.5
Lefkowitz, R.J.6
-
250
-
-
84879787863
-
Novel designer receptors to probe GPCR signaling and physiology
-
J. Wess, K. Nakajima, and S. Jain Novel designer receptors to probe GPCR signaling and physiology Trends Pharmacol Sci 34 2013 385 392
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 385-392
-
-
Wess, J.1
Nakajima, K.2
Jain, S.3
-
251
-
-
80053615320
-
The significance of G Protein-coupled receptor crystallography for drug discovery
-
J.A. Salon, D.T. Lodowski, and K. Palczewski The significance of G Protein-coupled receptor crystallography for drug discovery Pharmacol Rev 63 2011 901 937
-
(2011)
Pharmacol Rev
, vol.63
, pp. 901-937
-
-
Salon, J.A.1
Lodowski, D.T.2
Palczewski, K.3
-
252
-
-
0032478818
-
+ conduction and selectivity
-
DOI 10.1126/science.280.5360.69
-
+ conduction and selectivity Science 280 1998 69 77 (Pubitemid 28169082)
-
(1998)
Science
, vol.280
, Issue.5360
, pp. 69-77
-
-
Doyle, D.A.1
Cabral, J.M.2
Pfuetzner, R.A.3
Kuo, A.4
Gulbis, J.M.5
Cohen, S.L.6
Chait, B.T.7
MacKinnon, R.8
-
253
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
DOI 10.1126/science.289.5480.739
-
K. Palczewski, T. Kumasaka, T. Hori, C.A. Behnke, H. Motoshima, and B.A. Fox et al. Crystal structure of rhodopsin: a G protein-coupled receptor Science 289 2000 739 745 (Pubitemid 30650186)
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
254
-
-
36248970132
-
2 adrenergic G-protein-coupled receptor
-
DOI 10.1038/nature06325, PII NATURE06325
-
2-adrenergic G-protein-coupled receptor Nature 450 2007 383 387 (Pubitemid 350126755)
-
(2007)
Nature
, vol.450
, Issue.7168
, pp. 383-387
-
-
Rasmussen, S.G.F.1
Choi, H.-J.2
Rosenbaum, D.M.3
Kobilka, T.S.4
Thian, F.S.5
Edwards, P.C.6
Burghammer, M.7
Ratnala, V.R.P.8
Sanishvili, R.9
Fischetti, R.F.10
Schertler, G.F.X.11
Weis, W.I.12
Kobilka, B.K.13
-
255
-
-
30444442324
-
75 years of opioid research: The exciting but vain quest for the Holy Grail
-
A.D. Corbett, G. Henderson, A.T. McKnight, and S.J. Paterson 75 years of opioid research: the exciting but vain quest for the Holy Grail Br J Pharmacol 147 Suppl 1 2006 S153 S162
-
(2006)
Br J Pharmacol
, vol.147
, Issue.SUPPL. 1
-
-
Corbett, A.D.1
Henderson, G.2
McKnight, A.T.3
Paterson, S.J.4
-
256
-
-
84872221774
-
Structure-function of the G protein-coupled receptor superfamily
-
V. Katritch, V. Cherezov, and R.C. Stevens Structure-function of the G protein-coupled receptor superfamily Ann Rev Pharmacol Toxicol 53 2013 531 556
-
(2013)
Ann Rev Pharmacol Toxicol
, vol.53
, pp. 531-556
-
-
Katritch, V.1
Cherezov, V.2
Stevens, R.C.3
-
257
-
-
9144263000
-
High-throughput protein crystallography and drug discovery
-
DOI 10.1039/b314510g
-
I. Tickle, A. Sharff, M. Vinkovic, J. Yon, and H. Jhoti High-throughput protein crystallography and drug discovery Chem Soc Rev 33 2004 558 565 (Pubitemid 39540519)
-
(2004)
Chemical Society Reviews
, vol.33
, Issue.8
, pp. 558-565
-
-
Tickle, I.1
Sharff, A.2
Vinkovic, M.3
Yon, J.4
Jhoti, H.5
-
258
-
-
33744478144
-
Crystallization to obtain protein-ligand complexes for structure-aided drug design
-
DOI 10.1107/S0907444906012601
-
D.E. Danley Crystallization to obtain protein-ligand complexes for structure-aided drug design Acta Crystallogr D Biol Crystallogr 62 2006 569 575 (Pubitemid 43806633)
-
(2006)
Acta Crystallographica Section D: Biological Crystallography
, vol.62
, Issue.6
, pp. 569-575
-
-
Danley, D.E.1
-
259
-
-
33846460839
-
Crystallization of protein-ligand complexes
-
DOI 10.1107/S0907444906047020, PII S0907444906047020
-
A.M. Hassell, G. An, R.K. Bledsoe, J.M. Bynum, H.L. Carter III, and S.-J.J. Deng et al. Crystallization of protein-ligand complexes Acta Crystallogr D Biol Crystallogr 63 2007 72 79 (Pubitemid 46141482)
-
(2006)
Acta Crystallographica Section D: Biological Crystallography
, vol.63
, Issue.1
, pp. 72-79
-
-
Hassell, A.M.1
An, G.2
Bledsoe, R.K.3
Bynum, J.M.4
Carter III, H.L.5
Deng, S.-J.J.6
Gampe, R.T.7
Grisard, T.E.8
Madauss, K.P.9
Nolte, R.T.10
Rocque, W.J.11
Wang, L.12
Weaver, K.L.13
Williams, S.P.14
Wisely, G.B.15
Xu, R.16
Shewchuk, L.M.17
-
260
-
-
84857456514
-
Drug design for ever, from hype to hope
-
G. Seddon, V. Lounnas, R. McGuire, T. van den Bergh, R.P. Bywater, and L. Oliveira et al. Drug design for ever, from hype to hope J Comput-Aided Mol Des 26 2012 137 150
-
(2012)
J Comput-Aided Mol des
, vol.26
, pp. 137-150
-
-
Seddon, G.1
Lounnas, V.2
McGuire, R.3
Van Den Bergh, T.4
Bywater, R.P.5
Oliveira, L.6
-
261
-
-
0029836953
-
Discovering high-affinity ligands for proteins: SAR by NMR
-
DOI 10.1126/science.274.5292.1531
-
S.B. Shuker, P.J. Hajduk, R.P. Meadows, and S.W. Fesik Discovering high-affinity ligands for proteins: SAR by NMR Science 274 1996 1531 1534 (Pubitemid 26403929)
-
(1996)
Science
, vol.274
, Issue.5292
, pp. 1531-1534
-
-
Shuker, S.B.1
Hajduk, P.J.2
Meadows, R.P.3
Fesik, S.W.4
-
262
-
-
84879844246
-
Fragment-based drug discovery using NMR spectroscopy
-
M.J. Harner, A.O. Frank, and S.W. Fesik Fragment-based drug discovery using NMR spectroscopy J Biomol NMR 56 2013 65 75
-
(2013)
J Biomol NMR
, vol.56
, pp. 65-75
-
-
Harner, M.J.1
Frank, A.O.2
Fesik, S.W.3
-
263
-
-
10144253170
-
Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells
-
DOI 10.1074/jbc.271.31.18363
-
G.K. Akbar, V.R. Dasari, T.E. Webb, K. Ayyanathan, K. Pillarisetti, and A.K. Sandhu et al. Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells J Biol Chem 271 1996 18363 18367 (Pubitemid 26322690)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.31
, pp. 18363-18367
-
-
Akbar, G.K.M.1
Dasari, V.R.2
Webb, T.E.3
Ayyanathan, K.4
Pillarisetti, K.5
Sandhu, A.K.6
Athwal, R.S.7
Daniel, J.L.8
Ashby, B.9
Barnard, E.A.10
Kunapuli, S.P.11
-
264
-
-
0031587949
-
Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7
-
DOI 10.1006/bbrc.1997.6884
-
C.L. Herold, Q. Li, J.B. Schachter, T.K. Harden, and R.A. Nicholas Lack of nucleotide-promoted second messenger signaling responses in 1321N1 cells expressing the proposed P2Y receptor, p2y7 Biochem Biophys Res Commun 235 1997 717 721 (Pubitemid 27326550)
-
(1997)
Biochemical and Biophysical Research Communications
, vol.235
, Issue.3
, pp. 717-721
-
-
Herold, C.L.1
Li, Q.2
Schachter, J.B.3
Harden, T.K.4
Nicholas, R.A.5
-
265
-
-
0030976460
-
4 that mediates chemotaxis
-
DOI 10.1038/42506
-
T. Yokomizo, T. Izumi, K. Chang, Y. Takuwa, and T. Shimizu A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis Nature 387 1997 620 624 (Pubitemid 27248768)
-
(1997)
Nature
, vol.387
, Issue.6633
, pp. 620-624
-
-
Yokomizo, T.1
Izumi, T.2
Chang, K.3
Takuwa, Y.4
Shimizu, T.5
-
267
-
-
0036728491
-
Licensing research tool patents
-
G.J. Flattman, and J.M. Kaplan Licensing research tool patents Nat Biotechnol 20 2002 945 947
-
(2002)
Nat Biotechnol
, vol.20
, pp. 945-947
-
-
Flattman, G.J.1
Kaplan, J.M.2
-
268
-
-
79955428497
-
The NCGC pharmaceutical collection: A comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics
-
80ps16
-
R. Huang, N. Southall, Y. Wang, A. Yasgar, P. Shinn, and A. Jadhav et al. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics Sci Transl Med 3 2011 80ps16
-
(2011)
Sci Transl Med
, vol.3
-
-
Huang, R.1
Southall, N.2
Wang, Y.3
Yasgar, A.4
Shinn, P.5
Jadhav, A.6
-
269
-
-
2642580020
-
Quality assessment of the human genome sequence
-
DOI 10.1038/nature02390
-
J. Schmutz, J. Wheeler, J. Grimwood, M. Dickson, J. Yang, and C. Caoile et al. Quality assessment of the human genome sequence Nature 429 2004 365 368 (Pubitemid 38715122)
-
(2004)
Nature
, vol.429
, Issue.6990
, pp. 365-368
-
-
Schmutz, J.1
Wheeler, J.2
Grimwood, J.3
Dickson, M.4
Yang, J.5
Caolle, C.6
Bajorek, E.7
Black, S.8
Chan, Y.M.9
Denys, M.10
Escobar, J.11
Flowers, D.12
Fotopulos, D.13
Garcia, C.14
Gomez, M.15
Gonzales, E.16
Haydu, L.17
Lopez, F.18
Ramirez, L.19
Retterer, J.20
Rodriguez, A.21
Rogers, S.22
Salazar, A.23
Tsai, M.24
Myers, R.M.25
more..
-
270
-
-
84879627975
-
Next-Generation Sequencing Platforms
-
E.R. Mardis Next-Generation Sequencing Platforms Annu Rev Anal Chem 6 2013 287 303
-
(2013)
Annu Rev Anal Chem
, vol.6
, pp. 287-303
-
-
Mardis, E.R.1
-
271
-
-
77955596399
-
Next-generation, genome sequencing-based biomarkers: Concerns and challenges for medical practice
-
D.H. Roukos Next-generation, genome sequencing-based biomarkers: concerns and challenges for medical practice Biomarker Med 4 2010 583 586
-
(2010)
Biomarker Med
, vol.4
, pp. 583-586
-
-
Roukos, D.H.1
-
272
-
-
68949191441
-
Genome-based prediction of common diseases: Methodological considerations for future research
-
A.C.J.W. Janssens, and C.M. van Duijn Genome-based prediction of common diseases: methodological considerations for future research Genome Med 1 2009 20
-
(2009)
Genome Med
, vol.1
, pp. 20
-
-
Janssens, A.C.J.W.1
Van Duijn, C.M.2
-
273
-
-
8844232706
-
Functional genomics to new drug targets
-
DOI 10.1038/nrd1552
-
R. Kramer, and D. Cohen Functional genomics to new drug targets Nat Rev Drug Discov 3 2004 965 972 (Pubitemid 39529932)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.11
, pp. 965-972
-
-
Kramer, R.1
Cohen, D.2
-
274
-
-
70350690962
-
Systems pharmacology and genome medicine: A future perspective
-
A.D. Wist, S.I. Berger, and R. Iyengar Systems pharmacology and genome medicine: a future perspective Genome Med 1 2009 11
-
(2009)
Genome Med
, vol.1
, pp. 11
-
-
Wist, A.D.1
Berger, S.I.2
Iyengar, R.3
-
275
-
-
0037464588
-
A vision for the future of genomics research
-
DOI 10.1038/nature01626
-
F.S. Collins, E.D. Green, A.E. Guttmacher, and M.S. Guyer US National Human Genome Research Institute. A vision for the future of genomics research Nature 422 2003 835 847 (Pubitemid 36520032)
-
(2003)
Nature
, vol.422
, Issue.6934
, pp. 835-847
-
-
Collins, F.S.1
Green, E.D.2
Guttmacher, A.E.3
Guyer, M.S.4
-
277
-
-
77950440741
-
Has the revolution arrived?
-
F.S. Collins Has the revolution arrived? Nature 464 2010 674 675
-
(2010)
Nature
, vol.464
, pp. 674-675
-
-
Collins, F.S.1
-
278
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
[ePub August 14]
-
L.B. Alexandrov, S. Nik-Zainal, D.C. Wedge, S.A.J.R. Aparicio, S. Behjati, and A.V. Biankin et al. Signatures of mutational processes in human cancer Nature 2013 [ePub August 14]
-
(2013)
Nature
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Aparicio, S.A.J.R.4
Behjati, S.5
Biankin, A.V.6
-
279
-
-
84875707717
-
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
-
P.D.P. Pharoah, Y.-Y. Tsai, S.J. Ramus, C.M. Phelan, E.L. Goode, and K. Lawrenson GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer Nat Genet 45 2013 362 370
-
(2013)
Nat Genet
, vol.45
, pp. 362-370
-
-
Pharoah, P.D.P.1
Tsai, Y.-Y.2
Ramus, S.J.3
Phelan, C.M.4
Goode, E.L.5
Lawrenson, K.6
-
280
-
-
84871005700
-
Promises, delivery and challenges of inflammatory bowel disease risk disease discovery
-
S.R. Brant Promises, delivery and challenges of inflammatory bowel disease risk disease discovery Clin Gastroenterol Hepatol 11 2013 22 26
-
(2013)
Clin Gastroenterol Hepatol
, vol.11
, pp. 22-26
-
-
Brant, S.R.1
-
281
-
-
79959216005
-
Genetics and pathogenesis of inflammatory bowel disease
-
B. Khor, A. Gardet, and R.J. Xavier Genetics and pathogenesis of inflammatory bowel disease Nature 474 2011 307 317
-
(2011)
Nature
, vol.474
, pp. 307-317
-
-
Khor, B.1
Gardet, A.2
Xavier, R.J.3
-
282
-
-
80054975975
-
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
-
M.A. Rivas, M. Beaudoin, A. Gardet, C. Stevens, Y. Sharma, and C.K. Zhang et al. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease Nat Genet 43 2011 1066 1073
-
(2011)
Nat Genet
, vol.43
, pp. 1066-1073
-
-
Rivas, M.A.1
Beaudoin, M.2
Gardet, A.3
Stevens, C.4
Sharma, Y.5
Zhang, C.K.6
-
283
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
S. Jones, X. Zhang, D.W. Parsons, J.C.-H. Lin, R.J. Leary, and P. Angenendt et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 2008 1801 1806
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.-H.4
Leary, R.J.5
Angenendt, P.6
-
284
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
D.W. Parsons, S. Jones, X. Zhang, J.C.-H. Lin, R.J. Leary, and P. Angenendt et al. An integrated genomic analysis of human glioblastoma multiforme Science 321 2008 1807 1812
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.-H.4
Leary, R.J.5
Angenendt, P.6
-
285
-
-
34548825795
-
Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia
-
DOI 10.1182/blood-2007-03-066936
-
T. O'Hare, and C.A. Eide Deininger MWN Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia Blood 110 2007 2242 2249 (Pubitemid 47523141)
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2242-2249
-
-
O'Hare, T.1
Eide, C.A.2
Deininger, M.W.N.3
-
286
-
-
84885957225
-
Genome-based cancer therapeutics: Targets, kinase drug resistance and future strategies for precision oncology
-
P. Workman, B. Al-Lazikani, and P.A. Clarke Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology Curr Opin Pharmacol 13 2013 486 496
-
(2013)
Curr Opin Pharmacol
, vol.13
, pp. 486-496
-
-
Workman, P.1
Al-Lazikani, B.2
Clarke, P.A.3
-
287
-
-
84864225382
-
Methods: Face up to false positives
-
D. MacArthur Methods: face up to false positives Nature 487 2012 427 428
-
(2012)
Nature
, vol.487
, pp. 427-428
-
-
Macarthur, D.1
-
288
-
-
84880507665
-
Mutational heterogeneity in cancer and the search for new cancer-associated genes
-
M.S. Lawrence, P. Stojanov, P. Polak, G.V. Kryukov, K. Cibulskis, and A. Sivachenko et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes Nature 499 2013 214 218
-
(2013)
Nature
, vol.499
, pp. 214-218
-
-
Lawrence, M.S.1
Stojanov, P.2
Polak, P.3
Kryukov, G.V.4
Cibulskis, K.5
Sivachenko, A.6
-
289
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
M. Gerlinger, A.J. Rowan, S. Horswell, J. Larkin, D. Endesfelder, and E. Gronroos et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing N Engl J Med 366 2012 883 892
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
-
290
-
-
17644365470
-
The end of "naIve reductionism": Rise of systems biology or renaissance of physiology?
-
K. Strange The end of "naIve reductionism": rise of systems biology or renaissance of physiology? Am J Physiol Cell Physiol 288 2005 C968 C974
-
(2005)
Am J Physiol Cell Physiol
, vol.288
-
-
Strange, K.1
-
292
-
-
84864801155
-
Drug discovery in the age of systems biology: The rise of computational approaches for data integration
-
M. Iskar, G. Zeller, X.-M. Zhao, V. van Noort, and P. Bork Drug discovery in the age of systems biology: the rise of computational approaches for data integration Curr Opin Biotechnol 23 2012 609 616
-
(2012)
Curr Opin Biotechnol
, vol.23
, pp. 609-616
-
-
Iskar, M.1
Zeller, G.2
Zhao, X.-M.3
Van Noort, V.4
Bork, P.5
-
293
-
-
77951644400
-
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
-
J.V. Olsen, M. Vermeulen, A. Santamaria, C. Kumar, M.L. Miller, and L.J. Jensen et al. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis Sci Signal 3 2010 ra3
-
(2010)
Sci Signal
, vol.3
, pp. 3
-
-
Olsen, J.V.1
Vermeulen, M.2
Santamaria, A.3
Kumar, C.4
Miller, M.L.5
Jensen, L.J.6
-
294
-
-
84864816997
-
Protein phosphorylation from the perspective of systems biology
-
A. Derouiche, C. Cousin, and I. Mijakovic Protein phosphorylation from the perspective of systems biology Curr Opin Biotechnol 23 2012 585 590
-
(2012)
Curr Opin Biotechnol
, vol.23
, pp. 585-590
-
-
Derouiche, A.1
Cousin, C.2
Mijakovic, I.3
-
295
-
-
84863204946
-
Drug repurposing programmes get lift off
-
A. Mullard Drug repurposing programmes get lift off Nat Rev Drug Discov 11 2011 505 506
-
(2011)
Nat Rev Drug Discov
, vol.11
, pp. 505-506
-
-
Mullard, A.1
-
296
-
-
84860674656
-
Systems chemical biology and the Semantic Web: What they mean for the future of drug discovery research
-
D.J. Wild, Y. Ding, A.P. Sheth, L. Harland, E.M. Gifford, and M.S. Lajiness Systems chemical biology and the Semantic Web: what they mean for the future of drug discovery research Drug Discov Today 17 2012 469 474
-
(2012)
Drug Discov Today
, vol.17
, pp. 469-474
-
-
Wild, D.J.1
Ding, Y.2
Sheth, A.P.3
Harland, L.4
Gifford, E.M.5
Lajiness, M.S.6
-
297
-
-
84875458314
-
Target identification and mechanism of action in chemical biology and drug discovery
-
M. Schenone, V. Dančík, B.K. Wagner, and P.A. Clemons Target identification and mechanism of action in chemical biology and drug discovery Nature Chem Biol 9 2013 232 240
-
(2013)
Nature Chem Biol
, vol.9
, pp. 232-240
-
-
Schenone, M.1
Dančík, V.2
Wagner, B.K.3
Clemons, P.A.4
-
299
-
-
84872596110
-
Reuse of public genome-wide gene expression data
-
J. Rung, and A. Brazma Reuse of public genome-wide gene expression data Nat Rev Genet 14 2013 89 99
-
(2013)
Nat Rev Genet
, vol.14
, pp. 89-99
-
-
Rung, J.1
Brazma, A.2
-
300
-
-
84892366802
-
-
Fourth Estate London
-
B. Goldacre Bad medicine 2012 Fourth Estate London 1 99
-
(2012)
Bad Medicine
, pp. 1-99
-
-
Goldacre, B.1
-
302
-
-
0036729047
-
Can a biologist fix a radio? - Or, what I learned while studying apoptosis
-
DOI 10.1016/S1535-6108(02)00133-2
-
Y. Lazebnik Can a biologist fix a radio? - Or, what I learned while studying apoptosis Cancer Cell 2 2002 179 182 (Pubitemid 41043973)
-
(2002)
Cancer Cell
, vol.2
, Issue.3
, pp. 179-182
-
-
Lazebnik, Y.1
-
303
-
-
84865812140
-
ENCODE project writes euology for Junk DNA
-
E. Pennisi ENCODE project writes euology for Junk DNA Science 337 2012 1159 1160
-
(2012)
Science
, vol.337
, pp. 1159-1160
-
-
Pennisi, E.1
-
304
-
-
16644399734
-
Guest editorial: Systems biology, the second time around
-
C. DeLisi Guest editorial: systems biology, the second time around Environ Health Perspect 112 2004 A926 A927
-
(2004)
Environ Health Perspect
, vol.112
-
-
Delisi, C.1
-
305
-
-
0043069489
-
Drug research: Myths, hype and reality
-
H. Kubinyi Drug research: myths, hype and reality Nat Rev Drug Discov 2 2003 665 668 (Pubitemid 37368830)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.8
, pp. 665-668
-
-
Kubinyi, H.1
-
307
-
-
84892372344
-
Animal models of human disease: Challenges in enabling translation
-
P. McGonigle, and B.A. Ruggeri Animal models of human disease: challenges in enabling translation Biochem Pharmacol 87 2014 162 171
-
(2014)
Biochem Pharmacol
, vol.87
, pp. 162-171
-
-
McGonigle, P.1
Ruggeri, B.A.2
-
310
-
-
0024396459
-
Drugs from emasculated hormones: The principle of syntopic antagonism
-
J. Black Drugs from emasculated hormones: the principle of syntopic antagonism Science 245 1989 486 493 (Pubitemid 19203998)
-
(1989)
Science
, vol.245
, Issue.4917
, pp. 486-493
-
-
Black, J.1
-
311
-
-
79954417242
-
The major impacts of James Black's drug discoveries on medicine and pharmacology
-
M.J.A. Walker The major impacts of James Black's drug discoveries on medicine and pharmacology Trends Pharmacol Sci 32 2011 183 188
-
(2011)
Trends Pharmacol Sci
, vol.32
, pp. 183-188
-
-
Walker, M.J.A.1
-
312
-
-
0026814794
-
Industry-University alliances in biomedical research
-
P. Cuatrecasas Industry-University alliances in biomedical research J Clin Pharamcol 32 1992 100 106
-
(1992)
J Clin Pharamcol
, vol.32
, pp. 100-106
-
-
Cuatrecasas, P.1
-
313
-
-
0035753026
-
Social benefits of a successful biomedical research company: Merck
-
P.R. Vagelos Social benefits of a successful biomedical research company: Merck Proc Am Philos Soc 145 2001 575 578
-
(2001)
Proc Am Philos Soc
, vol.145
, pp. 575-578
-
-
Vagelos, P.R.1
-
316
-
-
15444364957
-
A personal perspective on Dr. Paul Janssen
-
J. Black A personal perspective on Dr. Paul Janssen J Med Chem 48 2005 1687 1688
-
(2005)
J Med Chem
, vol.48
, pp. 1687-1688
-
-
Black, J.1
-
317
-
-
34548430961
-
Successful pharmaceutical discovery: Paul Janssen's concept of drug research
-
P.J. Lewi, and A. Smith Successful pharmaceutical discovery: Paul Janssen's concept of drug research R&D Manage 37 2007 355 361
-
(2007)
R&D Manage
, vol.37
, pp. 355-361
-
-
Lewi, P.J.1
Smith, A.2
-
318
-
-
39149113180
-
A tribute to Dr. Paul A.J. Janssen: Entrepreneur extraordinaire, innovative scientist, and significant contributor to anesthesiology
-
T.H. Stanley, T.D. Egan, and H. Van Aken A tribute to Dr. Paul A.J. Janssen: entrepreneur extraordinaire, innovative scientist, and significant contributor to anesthesiology Anesth Analg 106 2008 451 462
-
(2008)
Anesth Analg
, vol.106
, pp. 451-462
-
-
Stanley, T.H.1
Egan, T.D.2
Van Aken, H.3
-
319
-
-
33846701641
-
Where is the optimism? Warrior teachings to regain the drug discovery spirit
-
DOI 10.1016/j.drudis.2006.12.002, PII S1359644606004867
-
J. Uitdehaag Where is the optimism? Warrior teachings to regain the drug discovery spirit Drug Discov Today 12 2007 105 107 (Pubitemid 46188407)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.3-4
, pp. 105-107
-
-
Uitdehaag, J.C.M.1
-
320
-
-
41549131597
-
The conductor and his orchestra
-
P.J. Lewi The conductor and his orchestra Drug Discov Today 13 2008 281 284
-
(2008)
Drug Discov Today
, vol.13
, pp. 281-284
-
-
Lewi, P.J.1
-
321
-
-
26044482076
-
Case history: The discovery of fluoxetine hydrochloride (Prozac)
-
DOI 10.1016/j.ajo.2005.02.011, PII N1821
-
D.T. Wong, K.W. Perry, and F.P. Bymaster Case history: the discovery of fluoxetine hydrochloride (Prozac) Nat Rev Drug Discov 4 2005 764 774 (Pubitemid 43090497)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.9
, pp. 764-774
-
-
Wong, D.T.1
Perry, K.W.2
Bymaster, F.P.3
-
322
-
-
79959786193
-
How to revive breakthrough innovation in the pharmaceutical industry
-
89cm16
-
B.H. Munos, and W.W. Chin How to revive breakthrough innovation in the pharmaceutical industry Sci Transl Med 3 2011 89cm16
-
(2011)
Sci Transl Med
, vol.3
-
-
Munos, B.H.1
Chin, W.W.2
-
323
-
-
84883151533
-
A forensic analysis of drug targets from 2000 through 2012
-
B. Munos A forensic analysis of drug targets from 2000 through 2012 Clin Pharmacol Ther 94 2013 407 411
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 407-411
-
-
Munos, B.1
-
325
-
-
65649116136
-
Challenges in the search for drugs to treat central nervous system disorders
-
S.J. Enna, and M. Williams Challenges in the search for drugs to treat central nervous system disorders J Pharmacol Exp Ther 329 2009 404 411
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 404-411
-
-
Enna, S.J.1
Williams, M.2
-
326
-
-
0021259505
-
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration
-
B.J. Marshall, and J.R. Warren Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration Lancet 323 1984 1311 1315
-
(1984)
Lancet
, vol.323
, pp. 1311-1315
-
-
Marshall, B.J.1
Warren, J.R.2
-
327
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
Encode Project Consortium
-
ENCODE Project Consortium An integrated encyclopedia of DNA elements in the human genome Nature 489 2012 57 74
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
-
328
-
-
84875275808
-
On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE Genome
-
D. Graur, Y. Zheng, N. Price, R.B.R. Azevedo, R.A. Zufall, and E. Elhaik On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE Genome Biol Evolut 5 2013 578 590
-
(2013)
Biol Evolut
, vol.5
, pp. 578-590
-
-
Graur, D.1
Zheng, Y.2
Price, N.3
Azevedo, R.B.R.4
Zufall, R.A.5
Elhaik, E.6
-
329
-
-
84892368849
-
The use and misuse of statistical methodologies in pharmacology research
-
M. Marino The use and misuse of statistical methodologies in pharmacology research Biochem Pharmacol 87 2014 78 92
-
(2014)
Biochem Pharmacol
, vol.87
, pp. 78-92
-
-
Marino, M.1
-
330
-
-
84892374338
-
Biomarkers in pharmacology and drug discovery
-
D.C. Anderson, and K. Kodulka Biomarkers in pharmacology and drug discovery Biochem Pharmacol 87 2014 172 188
-
(2014)
Biochem Pharmacol
, vol.87
, pp. 172-188
-
-
Anderson, D.C.1
Kodulka, K.2
|