메뉴 건너뛰기




Volumn 33, Issue 3, 2012, Pages 154-164

GRK2: Multiple roles beyond G protein-coupled receptor desensitization

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BETA SYNUCLEIN; CAVEOLIN; CLATHRIN; CYCLIC AMP; CYCLIC AMP ACTIVATED GUANINE NUCLEOTIDE EXCHANGE PROTEIN; DOPAMINE RECEPTOR; EZRIN; FRAGILE X MENTAL RETARDATION PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE RALA; I KAPPA B KINASE ALPHA; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PEPTIDYLPROLYL ISOMERASE PIN1; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PROTEIN KINASE B; PROTEIN PATCHED 1; RADIXIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMOOTHENED PROTEIN; SYNAPTOPHYSIN; TUBULIN; UNCLASSIFIED DRUG;

EID: 84857911676     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2011.12.003     Document Type: Review
Times cited : (125)

References (97)
  • 1
    • 0037024360 scopus 로고    scopus 로고
    • Identification of G protein-coupled receptor genes from the human genome sequence
    • DOI 10.1016/S0014-5793(02)02775-8, PII S0014579302027758
    • S. Takeda Identification of G protein-coupled receptor genes from the human genome sequence FEBS Lett. 520 2002 97 101 (Pubitemid 34607281)
    • (2002) FEBS Letters , vol.520 , Issue.1-3 , pp. 97-101
    • Takeda, S.1    Kadowaki, S.2    Haga, T.3    Takaesu, H.4    Mitaku, S.5
  • 3
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by beta-arrestins
    • R.J. Lefkowitz, and S.K. Shenoy Transduction of receptor signals by beta-arrestins Science 308 2005 512 517
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 5
    • 0242721361 scopus 로고    scopus 로고
    • Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling
    • DOI 10.1042/BJ20031076
    • S.K. Shenoy, and R.J. Lefkowitz Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling Biochem. J. 375 2003 503 515 (Pubitemid 37433499)
    • (2003) Biochemical Journal , vol.375 , Issue.3 , pp. 503-515
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 6
    • 0030593035 scopus 로고    scopus 로고
    • Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization
    • S.S. Ferguson Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization Science 271 1996 363 366
    • (1996) Science , vol.271 , pp. 363-366
    • Ferguson, S.S.1
  • 7
    • 0029770657 scopus 로고    scopus 로고
    • Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor
    • O.B. Goodman Jr. Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor Nature 383 1996 447 450
    • (1996) Nature , vol.383 , pp. 447-450
    • Goodman, Jr.O.B.1
  • 8
    • 80052038573 scopus 로고    scopus 로고
    • Beta-arrestin-mediated receptor trafficking and signal transduction
    • S.K. Shenoy, and R.J. Lefkowitz Beta-arrestin-mediated receptor trafficking and signal transduction Trends Pharmacol. Sci. 32 2011 521 533
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 521-533
    • Shenoy, S.K.1    Lefkowitz, R.J.2
  • 9
    • 33947585981 scopus 로고    scopus 로고
    • Phosphorylation-independent attenuation of GPCR signalling
    • DOI 10.1016/j.tips.2007.02.008, PII S016561470700051X
    • S.S. Ferguson Phosphorylation-independent attenuation of GPCR signalling Trends Pharmacol. Sci. 28 2007 173 179 (Pubitemid 46483720)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.4 , pp. 173-179
    • Ferguson, S.S.G.1
  • 10
    • 77952840083 scopus 로고    scopus 로고
    • The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets
    • P. Penela The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets Br. J. Pharmacol. 160 2010 821 832
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 821-832
    • Penela, P.1
  • 11
    • 33947375174 scopus 로고    scopus 로고
    • Physiological roles of G protein-coupled receptor kinases and arrestins
    • DOI 10.1146/annurev.physiol.69.022405.154731
    • R.T. Premont, and R.R. Gainetdinov Physiological roles of G protein-coupled receptor kinases and arrestins Annu. Rev. Physiol. 69 2007 511 534 (Pubitemid 46457653)
    • (2007) Annual Review of Physiology , vol.69 , pp. 511-534
    • Premont, R.T.1    Gainetdinov, R.R.2
  • 12
    • 33646162635 scopus 로고    scopus 로고
    • GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling
    • E. Reiter, and R.J. Lefkowitz GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling Trends Endocrinol. Metab. 17 2006 159 165
    • (2006) Trends Endocrinol. Metab. , vol.17 , pp. 159-165
    • Reiter, E.1    Lefkowitz, R.J.2
  • 14
    • 79959804711 scopus 로고    scopus 로고
    • Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of Smoothened
    • Y. Chen Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of Smoothened PLoS Biol. 9 2011 e1001083
    • (2011) PLoS Biol. , vol.9 , pp. 1001083
    • Chen, Y.1
  • 15
    • 79961010813 scopus 로고    scopus 로고
    • Growth arrest specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling
    • T. Evron Growth arrest specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling J. Biol. Chem. 286 2011 27676 27686
    • (2011) J. Biol. Chem. , vol.286 , pp. 27676-27686
    • Evron, T.1
  • 17
    • 59349091148 scopus 로고    scopus 로고
    • Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase
    • M. Philipp Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase Mol. Biol. Cell 19 2008 5478 5489
    • (2008) Mol. Biol. Cell , vol.19 , pp. 5478-5489
    • Philipp, M.1
  • 19
    • 0034111099 scopus 로고    scopus 로고
    • Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: Direct interaction of kinase N terminus with activated G(αq)
    • M. Sallese Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq Mol. Pharmacol. 57 2000 826 831 (Pubitemid 30183726)
    • (2000) Molecular Pharmacology , vol.57 , Issue.4 , pp. 826-831
    • Sallese, M.1    Mariggio, S.2    D'Urbano, E.3    Iacovelli, L.4    De Blasi, A.5
  • 20
    • 80053089071 scopus 로고    scopus 로고
    • Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane
    • A.P. Boughton Heterotrimeric G protein beta1gamma2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane Proc. Natl. Acad. Sci. U.S.A. 108 2011 E667 E673
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108
    • Boughton, A.P.1
  • 22
    • 79953192547 scopus 로고    scopus 로고
    • Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code
    • A.J. Butcher Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code J. Biol. Chem. 286 2011 11506 11518
    • (2011) J. Biol. Chem. , vol.286 , pp. 11506-11518
    • Butcher, A.J.1
  • 23
    • 80051616441 scopus 로고    scopus 로고
    • Distinct phosphorylation sites on the {beta}2-adrenergic receptor establish a barcode that encodes differential functions of {beta}-arrestin
    • K.N. Nobles Distinct phosphorylation sites on the {beta}2-adrenergic receptor establish a barcode that encodes differential functions of {beta}-arrestin Sci. Signal. 4 2011 ra51
    • (2011) Sci. Signal. , vol.4 , pp. 51
    • Nobles, K.N.1
  • 24
    • 0346874333 scopus 로고    scopus 로고
    • Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2
    • DOI 10.1038/nature02158
    • K. Lorenz Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 Nature 426 2003 574 579 (Pubitemid 37522645)
    • (2003) Nature , vol.426 , Issue.6966 , pp. 574-579
    • Lorenz, K.1    Lohse, M.J.2    Quitterer, U.3
  • 25
    • 0035375104 scopus 로고    scopus 로고
    • Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration
    • S.V. Naga Prasad Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration J. Biol. Chem. 276 2001 18953 18959
    • (2001) J. Biol. Chem. , vol.276 , pp. 18953-18959
    • Naga Prasad, S.V.1
  • 26
    • 0036327388 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulates β2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/β-arrestin complex
    • DOI 10.1083/jcb.200202113
    • S.V. Naga Prasad Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex J. Cell Biol. 158 2002 563 575 (Pubitemid 34851714)
    • (2002) Journal of Cell Biology , vol.158 , Issue.3 , pp. 563-575
    • Naga Prasad, S.V.1    Laporte, S.A.2    Chamberlain, D.3    Caron, M.G.4    Barak, L.5    Rockman, H.A.6
  • 27
    • 19644397920 scopus 로고    scopus 로고
    • Restoration of β-adrenergic receptor signaling and contractile function in heart failure by disruption of the βARKl/phosphoinositide 3-kinase complex
    • DOI 10.1161/CIRCULATIONAHA.104.508796
    • C. Perrino Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/ phosphoinositide 3-kinase complex Circulation 111 2005 2579 2587 (Pubitemid 40740856)
    • (2005) Circulation , vol.111 , Issue.20 , pp. 2579-2587
    • Perrino, C.1    Prasad, S.V.N.2    Schroder, J.N.3    Hata, J.A.4    Milano, C.5    Rockman, H.A.6
  • 28
    • 0041022398 scopus 로고    scopus 로고
    • β-adrenergic receptor kinase (GRK2) colocalizes with β-adrenergic receptors during agonist-induced receptor internalization
    • DOI 10.1074/jbc.272.15.9601
    • A. Ruiz-Gomez, and F. Mayor Jr. Beta-adrenergic receptor kinase (GRK2) colocalizes with beta-adrenergic receptors during agonist-induced receptor internalization J. Biol. Chem. 272 1997 9601 9604 (Pubitemid 27171614)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.15 , pp. 9601-9604
    • Ruiz-Gomez, A.1    Mayor Jr., F.2
  • 29
    • 0035980124 scopus 로고    scopus 로고
    • Clathrin box in G protein-coupled receptor kinase 2
    • T. Shiina Clathrin box in G protein-coupled receptor kinase 2 J. Biol. Chem. 276 2001 33019 33026
    • (2001) J. Biol. Chem. , vol.276 , pp. 33019-33026
    • Shiina, T.1
  • 30
    • 79960710835 scopus 로고    scopus 로고
    • Regulation of c3a receptor signaling in human mast cells by G protein coupled receptor kinases
    • Q. Guo Regulation of c3a receptor signaling in human mast cells by G protein coupled receptor kinases PLoS ONE 6 2011 e22559
    • (2011) PLoS ONE , vol.6 , pp. 22559
    • Guo, Q.1
  • 32
    • 13444270337 scopus 로고    scopus 로고
    • Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor
    • X.R. Ren Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor Proc. Natl. Acad. Sci. U.S.A. 102 2005 1448 1453
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 1448-1453
    • Ren, X.R.1
  • 35
    • 0034698059 scopus 로고    scopus 로고
    • The GIT family of ADP-ribosylation factor GTPase-activating proteins: Functional diversity of GIT2 through alternative splicing
    • DOI 10.1074/jbc.275.29.22373
    • R.T. Premont The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing J. Biol. Chem. 275 2000 22373 22380 (Pubitemid 30621823)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.29 , pp. 22373-22380
    • Premont, R.T.1    Claing, A.2    Vitale, N.3    Perry, S.J.4    Lefkowitz, R.J.5
  • 36
    • 0042029729 scopus 로고    scopus 로고
    • Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-Gβγ complex on membrane is required for GRK2 function in vivo
    • DOI 10.1074/jbc.M302385200
    • J. Li Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo J. Biol. Chem. 278 2003 30219 30226 (Pubitemid 36962416)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.32 , pp. 30219-30226
    • Li, J.1    Xiang, B.2    Su, W.3    Zhang, X.4    Huang, Y.5    Ma, L.6
  • 37
    • 0026803164 scopus 로고
    • Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors
    • J.A. Pitcher Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors Science 257 1992 1264 1267
    • (1992) Science , vol.257 , pp. 1264-1267
    • Pitcher, J.A.1
  • 38
    • 79251506646 scopus 로고    scopus 로고
    • Nonenzymatic rapid control of GIRK channel function by a G protein-coupled receptor kinase
    • A. Raveh Nonenzymatic rapid control of GIRK channel function by a G protein-coupled receptor kinase Cell 143 2010 750 760
    • (2010) Cell , vol.143 , pp. 750-760
    • Raveh, A.1
  • 39
    • 69949181911 scopus 로고    scopus 로고
    • Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons
    • F.M. Ribeiro Phosphorylation-independent regulation of metabotropic glutamate receptor 5 desensitization and internalization by G protein-coupled receptor kinase 2 in neurons J. Biol. Chem. 284 2009 23444 23453
    • (2009) J. Biol. Chem. , vol.284 , pp. 23444-23453
    • Ribeiro, F.M.1
  • 40
  • 41
    • 27644433164 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Gαq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes
    • DOI 10.1210/me.2004-0429
    • I. Usui G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes Mol. Endocrinol. 19 2005 2760 2768 (Pubitemid 41577248)
    • (2005) Molecular Endocrinology , vol.19 , Issue.11 , pp. 2760-2768
    • Usui, I.1    Imamura, T.2    Babendure, J.L.3    Satoh, H.4    Lu, J.-C.5    Hupfeld, C.J.6    Olefsky, J.M.7
  • 42
    • 80051697652 scopus 로고    scopus 로고
    • Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2
    • N. Fernandez Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2 J. Biol. Chem. 286 2011 28697 28706
    • (2011) J. Biol. Chem. , vol.286 , pp. 28697-28706
    • Fernandez, N.1
  • 43
    • 64849098229 scopus 로고    scopus 로고
    • Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK
    • A.I. Aziziyeh Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK Cell Signal. 21 2009 1207 1217
    • (2009) Cell Signal. , vol.21 , pp. 1207-1217
    • Aziziyeh, A.I.1
  • 44
    • 80053345544 scopus 로고    scopus 로고
    • GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood
    • T.I. Arnon GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood Science 333 2011 1898 1903
    • (2011) Science , vol.333 , pp. 1898-1903
    • Arnon, T.I.1
  • 46
    • 67049101075 scopus 로고    scopus 로고
    • New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration
    • P. Penela New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration Cell Adh. Migr. 3 2009 19 23
    • (2009) Cell Adh. Migr. , vol.3 , pp. 19-23
    • Penela, P.1
  • 47
    • 24744444714 scopus 로고    scopus 로고
    • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
    • DOI 10.1038/nm1289
    • S. Liu A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension Nat. Med. 11 2005 952 958 (Pubitemid 41294440)
    • (2005) Nature Medicine , vol.11 , Issue.9 , pp. 952-958
    • Liu, S.1    Premont, R.T.2    Kontos, C.D.3    Zhu, S.4    Rockey, D.C.5
  • 50
    • 77957193666 scopus 로고    scopus 로고
    • Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK
    • N. Eijkelkamp Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK J. Neurosci. 30 2010 12806 12815
    • (2010) J. Neurosci. , vol.30 , pp. 12806-12815
    • Eijkelkamp, N.1
  • 51
    • 76649125850 scopus 로고    scopus 로고
    • GRK2: A novel cell-specific regulator of severity and duration of inflammatory pain
    • N. Eijkelkamp GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain J. Neurosci. 30 2010 2138 2149
    • (2010) J. Neurosci. , vol.30 , pp. 2138-2149
    • Eijkelkamp, N.1
  • 53
    • 0032493759 scopus 로고    scopus 로고
    • Binding and phosphorylation of tubulin by G protein-coupled receptor kinases
    • DOI 10.1074/jbc.273.32.20308
    • C.V. Carman Binding and phosphorylation of tubulin by G protein-coupled receptor kinases J. Biol. Chem. 273 1998 20308 20316 (Pubitemid 28377594)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.32 , pp. 20308-20316
    • Carman, C.V.1    Som, T.2    Kim, C.M.3    Benovic, J.L.4
  • 54
    • 0032528248 scopus 로고    scopus 로고
    • GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin
    • DOI 10.1046/j.1432-1327.1998.2550363.x
    • K. Haga GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin Eur. J. Biochem. 255 1998 363 368 (Pubitemid 28340244)
    • (1998) European Journal of Biochemistry , vol.255 , Issue.2 , pp. 363-368
    • Haga, K.1    Ogawa, H.2    Haga, T.3    Murofushi, H.4
  • 56
    • 0037349646 scopus 로고    scopus 로고
    • Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in β-tubulin
    • DOI 10.1046/j.1432-1033.2003.03465.x
    • N. Yoshida Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin Eur. J. Biochem. 270 2003 1154 1163 (Pubitemid 36384448)
    • (2003) European Journal of Biochemistry , vol.270 , Issue.6 , pp. 1154-1163
    • Yoshida, N.1    Haga, K.2    Haga, T.3
  • 57
    • 33847246808 scopus 로고    scopus 로고
    • Taxol normalizes the impaired agonist-induced beta2-adrenoceptor internalization in splenocytes from GRK2+/- mice
    • A. Vroon Taxol normalizes the impaired agonist-induced beta2-adrenoceptor internalization in splenocytes from GRK2+/- mice Eur. J. Pharmacol. 560 2007 9 16
    • (2007) Eur. J. Pharmacol. , vol.560 , pp. 9-16
    • Vroon, A.1
  • 58
    • 77649275413 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells
    • A.W. Kahsai G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells Biochim. Biophys. Acta 1803 2010 300 310
    • (2010) Biochim. Biophys. Acta , vol.1803 , pp. 300-310
    • Kahsai, A.W.1
  • 59
    • 21844467495 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2-mediated phosphorylation of Ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton
    • DOI 10.1091/mbc.E04-10-0877
    • S.H. Cant, and J.A. Pitcher G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton Mol. Biol. Cell 16 2005 3088 3099 (Pubitemid 40962582)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.7 , pp. 3088-3099
    • Cant, S.H.1    Pitcher, J.A.2
  • 60
    • 77957600228 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity
    • L. Garcia-Guerra G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity Diabetes 59 2010 2407 2417
    • (2010) Diabetes , vol.59 , pp. 2407-2417
    • Garcia-Guerra, L.1
  • 61
    • 79955782045 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia
    • M. Ciccarelli G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia Circulation 123 2011 1953 1962
    • (2011) Circulation , vol.123 , pp. 1953-1962
    • Ciccarelli, M.1
  • 62
    • 25144432973 scopus 로고    scopus 로고
    • The G protein-coupled receptor kinase-2 is a TGFβ-inducible antagonist of TGFβ signal transduction
    • DOI 10.1038/sj.emboj.7600794, PII 7600794
    • J. Ho The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction EMBO J. 24 2005 3247 3258 (Pubitemid 41348699)
    • (2005) EMBO Journal , vol.24 , Issue.18 , pp. 3247-3258
    • Ho, J.1    Cocolakis, E.2    Dumas, V.M.3    Posner, B.I.4    Laporte, S.A.5    Lebrun, J.-J.6
  • 63
    • 62749127825 scopus 로고    scopus 로고
    • TGFbeta-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration
    • J. Guo TGFbeta-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration Cell Signal. 21 2009 899 905
    • (2009) Cell Signal. , vol.21 , pp. 899-905
    • Guo, J.1
  • 64
    • 0034714204 scopus 로고    scopus 로고
    • Synucleins are a novel class of substrates for G protein-coupled receptor kinases
    • A.N. Pronin Synucleins are a novel class of substrates for G protein-coupled receptor kinases J. Biol. Chem. 275 2000 26515 26522
    • (2000) J. Biol. Chem. , vol.275 , pp. 26515-26522
    • Pronin, A.N.1
  • 65
    • 57149084065 scopus 로고    scopus 로고
    • Molecular and cellular biology of synucleins
    • A. Surguchov Molecular and cellular biology of synucleins Int. Rev. Cell Mol. Biol. 270 2008 225 317
    • (2008) Int. Rev. Cell Mol. Biol. , vol.270 , pp. 225-317
    • Surguchov, A.1
  • 66
    • 72449146904 scopus 로고    scopus 로고
    • G-protein-coupled-receptor kinases mediate TNFalpha-induced NFkappaB signalling via direct interaction with and phosphorylation of IkappaBalpha
    • S. Patial G-protein-coupled-receptor kinases mediate TNFalpha-induced NFkappaB signalling via direct interaction with and phosphorylation of IkappaBalpha Biochem. J. 425 2010 169 178
    • (2010) Biochem. J. , vol.425 , pp. 169-178
    • Patial, S.1
  • 68
    • 47849125977 scopus 로고    scopus 로고
    • Immunohistochemical detection, regulation and antiproliferative function of G-protein-coupled receptor kinase 2 in thyroid carcinomas
    • DOI 10.1677/JOE-07-0562
    • T. Metaye Immunohistochemical detection, regulation and antiproliferative function of G-protein-coupled receptor kinase 2 in thyroid carcinomas J. Endocrinol. 198 2008 101 110 (Pubitemid 352038189)
    • (2008) Journal of Endocrinology , vol.198 , Issue.1 , pp. 101-110
    • Metaye, T.1    Levillain, P.2    Kraimps, J.-L.3    Perdrisot, R.4
  • 69
    • 0033869812 scopus 로고    scopus 로고
    • Overexpression of G protein - Coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein - Coupled and platelet-derived growth factor receptors
    • K. Peppel Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells attenuates mitogenic signaling via G protein-coupled and platelet-derived growth factor receptors Circulation 102 2000 793 799 (Pubitemid 30643287)
    • (2000) Circulation , vol.102 , Issue.7 , pp. 793-799
    • Peppel, K.1    Jacobson, A.2    Huang, X.3    Murray, J.P.4    Oppermann, M.5    Freedman, N.J.6
  • 70
    • 75749118972 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression
    • P. Penela G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression Proc. Natl. Acad. Sci. U.S.A. 107 2010 1118 1123
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 1118-1123
    • Penela, P.1
  • 71
    • 84857497775 scopus 로고    scopus 로고
    • Growth inhibition of human hepatocellular carcinoma cells by overexpression of G protein-coupled receptor kinase 2
    • 10.1002/jcp.22972
    • Z. Wei Growth inhibition of human hepatocellular carcinoma cells by overexpression of G protein-coupled receptor kinase 2 J. Cell Physiol. 2011 10.1002/jcp.22972
    • (2011) J. Cell Physiol.
    • Wei, Z.1
  • 72
    • 67649836304 scopus 로고    scopus 로고
    • Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development
    • X. Jiang Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development Proc. Natl. Acad. Sci. U.S.A. 106 2009 10183 10188
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 10183-10188
    • Jiang, X.1
  • 73
    • 0033558141 scopus 로고    scopus 로고
    • Sequestration of dopamine D2 receptors depends on coexpression of G- protein-coupled receptor kinases 2 or 5
    • DOI 10.1046/j.1432-1327.1999.00125.x
    • K. Ito Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5 Eur. J. Biochem. 260 1999 112 119 (Pubitemid 29095701)
    • (1999) European Journal of Biochemistry , vol.260 , Issue.1 , pp. 112-119
    • Ito, K.1    Haga, T.2    Lameh, J.3    Sadee, W.4
  • 74
    • 0033565688 scopus 로고    scopus 로고
    • Dynamin and Rab5 regulate GRK2-dependent internalization of dopamine D2 receptors
    • DOI 10.1046/j.1432-1327.1999.00549.x
    • K. Iwata Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors Eur. J. Biochem. 263 1999 596 602 (Pubitemid 29337054)
    • (1999) European Journal of Biochemistry , vol.263 , Issue.2 , pp. 596-602
    • Iwata, K.1    Ito, K.2    Fukuzaki, A.3    Inaki, K.4    Haga, T.5
  • 75
    • 0030020424 scopus 로고    scopus 로고
    • Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases
    • DOI 10.1074/jbc.271.7.3771
    • M. Tiberi Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases J. Biol. Chem. 271 1996 3771 3778 (Pubitemid 26065697)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.7 , pp. 3771-3778
    • Tiberi, M.1    Nash, S.R.2    Bertrand, L.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 76
    • 77957797131 scopus 로고    scopus 로고
    • Cytoplasmic tail of D1 dopaminergic receptor differentially regulates desensitization and phosphorylation by G protein-coupled receptor kinase 2 and 3
    • K. Sedaghat, and M. Tiberi Cytoplasmic tail of D1 dopaminergic receptor differentially regulates desensitization and phosphorylation by G protein-coupled receptor kinase 2 and 3 Cell Signal. 23 2011 180 192
    • (2011) Cell Signal. , vol.23 , pp. 180-192
    • Sedaghat, K.1    Tiberi, M.2
  • 77
    • 67649321841 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor
    • Y. Namkung G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor J. Biol. Chem. 284 2009 15038 15051
    • (2009) J. Biol. Chem. , vol.284 , pp. 15038-15051
    • Namkung, Y.1
  • 78
    • 71749113078 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation
    • Y. Namkung G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation J. Biol. Chem. 284 2009 34103 34115
    • (2009) J. Biol. Chem. , vol.284 , pp. 34103-34115
    • Namkung, Y.1
  • 79
    • 39849085956 scopus 로고    scopus 로고
    • Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by L-DOPA treatment
    • DOI 10.1111/j.1471-4159.2007.05104.x
    • M.R. Ahmed Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment J. Neurochem. 104 2008 1622 1636 (Pubitemid 351316768)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.6 , pp. 1622-1636
    • Ahmed, M.R.1    Bychkov, E.2    Gurevich, V.V.3    Benovic, J.L.4    Gurevich, E.V.5
  • 80
    • 15944407993 scopus 로고    scopus 로고
    • L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain
    • DOI 10.1016/j.nbd.2004.10.005
    • E. Bezard L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain Neurobiol. Dis. 18 2005 323 335 (Pubitemid 40431116)
    • (2005) Neurobiology of Disease , vol.18 , Issue.2 , pp. 323-335
    • Bezard, E.1    Gross, C.E.2    Qin, L.3    Gurevich, V.V.4    Benovic, J.L.5    Gurevich, E.V.6
  • 81
    • 70349114286 scopus 로고    scopus 로고
    • Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration
    • J.A. Schroeder Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration Synapse 63 2009 863 870
    • (2009) Synapse , vol.63 , pp. 863-870
    • Schroeder, J.A.1
  • 82
    • 49849098290 scopus 로고    scopus 로고
    • FMRP acts as a key messenger for dopamine modulation in the forebrain
    • H. Wang FMRP acts as a key messenger for dopamine modulation in the forebrain Neuron 59 2008 634 647
    • (2008) Neuron , vol.59 , pp. 634-647
    • Wang, H.1
  • 83
    • 31644442906 scopus 로고    scopus 로고
    • Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
    • DOI 10.1242/dev.02169
    • D. Huangfu, and K.V. Anderson Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates Development 133 2006 3 14 (Pubitemid 43169315)
    • (2006) Development , vol.133 , Issue.1 , pp. 3-14
    • Huangfu, D.1    Anderson, K.V.2
  • 84
    • 59349106501 scopus 로고    scopus 로고
    • Hedgehog signaling: Is Smo a G protein-coupled receptor?
    • M. Philipp, and M.G. Caron Hedgehog signaling: is Smo a G protein-coupled receptor? Curr. Biol. 19 2009 R125 R127
    • (2009) Curr. Biol. , vol.19
    • Philipp, M.1    Caron, M.G.2
  • 87
    • 11144285406 scopus 로고    scopus 로고
    • β-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway
    • DOI 10.1126/science.1104193
    • A.M. Wilbanks Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway Science 306 2004 2264 2267 (Pubitemid 40024465)
    • (2004) Science , vol.306 , Issue.5705 , pp. 2264-2267
    • Wilbanks, A.M.1    Fralish, G.B.2    Kirby, M.L.3    Barak, L.S.4    Li, Y.-X.5    Caron, M.G.6
  • 90
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: A signalling centre during vertebrate development
    • S.C. Goetz, and K.V. Anderson The primary cilium: a signalling centre during vertebrate development Nat. Rev. Genet. 11 2010 331 344
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 91
    • 77955426475 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signaling: Cilia rule
    • C.W. Wilson, and D.Y. Stainier Vertebrate Hedgehog signaling: cilia rule BMC Biol. 8 2010 102
    • (2010) BMC Biol. , vol.8 , pp. 102
    • Wilson, C.W.1    Stainier, D.Y.2
  • 93
    • 77954086015 scopus 로고    scopus 로고
    • Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish
    • H.R. Kim Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish BMC Biol. 8 2010 65
    • (2010) BMC Biol. , vol.8 , pp. 65
    • Kim, H.R.1
  • 94
    • 56649123195 scopus 로고    scopus 로고
    • Targeting of beta-arrestin2 to the centrosome and primary cilium: Role in cell proliferation control
    • A. Molla-Herman Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control PLoS ONE 3 2008 e3728
    • (2008) PLoS ONE , vol.3 , pp. 3728
    • Molla-Herman, A.1
  • 96
    • 33745827399 scopus 로고    scopus 로고
    • Expanding the role of the dynein regulatory complex to non-axonemal functions: Association of GAS11 with the golgi apparatus
    • DOI 10.1111/j.1600-0854.2006.00411.x
    • J.R. Colantonio Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus Traffic 7 2006 538 548 (Pubitemid 44026752)
    • (2006) Traffic , vol.7 , Issue.5 , pp. 538-548
    • Colantonio, J.R.1    Bekker, J.M.2    Kim, S.J.3    Morrissey, K.M.4    Crosbie, R.H.5    Hill, K.L.6
  • 97
    • 58149352343 scopus 로고    scopus 로고
    • The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear
    • J.R. Colantonio The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear Nature 457 2009 205 209
    • (2009) Nature , vol.457 , pp. 205-209
    • Colantonio, J.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.