-
1
-
-
0037313517
-
Modern biomedical research: An internally self-consistent universe with little contact with medical reality?
-
Horrobin, D. F. Modern biomedical research: an internally self-consistent universe with little contact with medical reality? Nature Rev. Drug Discov. 2, 151-154 (2003).
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 151-154
-
-
Horrobin, D.F.1
-
2
-
-
0037404094
-
Strategic trends in the drug industry
-
Drews, J. Strategic trends in the drug industry. Drug Discov. Today 8, 411-420 (2003).
-
(2003)
Drug Discov. Today
, vol.8
, pp. 411-420
-
-
Drews, J.1
-
4
-
-
0032872173
-
How many leads from HTS?
-
Lahana, R. How many leads from HTS? Drug Discov. Today 4, 447-448 (1999).
-
(1999)
Drug Discov. Today
, vol.4
, pp. 447-448
-
-
Lahana, R.1
-
5
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski, C. A., Lombardo F., Dominy B. W. & Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Del. Rev. 23, 3-25 (1997).
-
(1997)
Adv. Drug Del. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
6
-
-
0034609833
-
Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties
-
Ertl, P., Rohde, B. & Selzer, P. Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties. J. Med. Chem. 43, 3714-3717 (2000).
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3714-3717
-
-
Ertl, P.1
Rohde, B.2
Selzer, P.3
-
7
-
-
0033800498
-
VolSurf: A new tool for the pharmacokinetic optimization of lead compounds
-
Cruciani, G., Pastor, M. & Guba, W. VolSurf: a new tool for the pharmacokinetic optimization of lead compounds. Eur. J. Pharm. Sci. 11 (Suppl. 2) S29-S39 (2000).
-
(2000)
Eur. J. Pharm. Sci.
, vol.11
, Issue.SUPPL. 2
-
-
Cruciani, G.1
Pastor, M.2
Guba, W.3
-
8
-
-
0032714220
-
Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs
-
Kelder, J., Grootenhuis, P. D., Bayada, D. M., Delbressine, L. P. & Ploemen, J. P. Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs. Pharm. Res. 16, 1514-1519(1999).
-
(1999)
Pharm. Res.
, vol.16
, pp. 1514-1519
-
-
Kelder, J.1
Grootenhuis, P.D.2
Bayada, D.M.3
Delbressine, L.P.4
Ploemen, J.P.5
-
9
-
-
0037434541
-
Absorption classification of oral drugs based on molecular surface properties
-
Bergström, C. A. S. et al. Absorption classification of oral drugs based on molecular surface properties. J. Med. Chem. 46, 558-570 (2003).
-
(2003)
J. Med. Chem.
, vol.46
, pp. 558-570
-
-
Bergström, C.A.S.1
-
10
-
-
0037030653
-
Molecular properties that influence the oral bioavailability of drug candidates
-
Veber, D. F. et al. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem. 45, 2615-2623 (2002).
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2615-2623
-
-
Veber, D.F.1
-
11
-
-
0037468884
-
A comparison of physicochemical property profiles of development and marketed oral drugs
-
Wenlock, M. C., Austin, R. P., Barton, P., Davis, A. M. & Leeson, P. D. A comparison of physicochemical property profiles of development and marketed oral drugs. J. Med. Chem. 46, 1250-1256 (2003).
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1250-1256
-
-
Wenlock, M.C.1
Austin, R.P.2
Barton, P.3
Davis, A.M.4
Leeson, P.D.5
-
12
-
-
0023947965
-
Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)
-
Prentis, R. A., Lis, Y. & Walker, S. R. Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985). Br. J. Clin. Pharmacol. 25, 387-396(1988).
-
(1988)
Br. J. Clin. Pharmacol.
, vol.25
, pp. 387-396
-
-
Prentis, R.A.1
Lis, Y.2
Walker, S.R.3
-
13
-
-
0030886937
-
Managing the drug discovery/development interface
-
Kennedy, T. Managing the drug discovery/ development interface. Drug Discov. Today 2, 436-444(1997).
-
(1997)
Drug Discov. Today
, vol.2
, pp. 436-444
-
-
Kennedy, T.1
-
14
-
-
0037364162
-
ADMET in silico modelling: Towards prediction paradise?
-
van de Waterbeemd, H. & Gifford, E. ADMET in silico modelling: towards prediction paradise? Nature Rev. Drug Discov. 2, 192-204 (2003).
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 192-204
-
-
van de Waterbeemd, H.1
Gifford, E.2
-
15
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
Lipinski, C. A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 44, 235-249 (2000).
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
-
16
-
-
0032572819
-
Can we learn to distinguish between 'drug-like' and 'nondrug-like' molecules?
-
Ajay, A., Walters, W. P. & Murcko, M. A. Can we learn to distinguish between 'drug-like' and 'nondrug-like' molecules? J. Med. Chem. 41, 3314-3324 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3314-3324
-
-
Ajay, A.1
Walters, W.P.2
Murcko, M.A.3
-
17
-
-
0032572816
-
A scoring scheme for discriminating between drugs and nondrugs
-
Sadowski, J. & Kubinyi, H. A scoring scheme for discriminating between drugs and nondrugs. J. Med. Chem. 41, 3325-3329 (1998).
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3325-3329
-
-
Sadowski, J.1
Kubinyi, H.2
-
18
-
-
0033576601
-
The design of leadlike combinatorial libraries
-
Teague, S. J., Davis, A. M., Leeson, P. D. & Oprea, T. The design of leadlike combinatorial libraries. Angew. Chem. Int. Ed. 38, 3743-3748 (1999).
-
(1999)
Angew. Chem. Int. Ed.
, vol.38
, pp. 3743-3748
-
-
Teague, S.J.1
Davis, A.M.2
Leeson, P.D.3
Oprea, T.4
-
19
-
-
0035438391
-
Is there a difference between leads and drugs? A historical perspective
-
Oprea, T. I., Davis, A. M., Teague, S. J. & Leeson, P. D. Is there a difference between leads and drugs? A historical perspective. J. Chem. Inf. Comput. Sci. 41, 1308-1316 (2001).
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 1308-1316
-
-
Oprea, T.I.1
Davis, A.M.2
Teague, S.J.3
Leeson, P.D.4
-
20
-
-
0037124196
-
Drugs, leads, and drug-likeness: An analysis of some recently launched drugs
-
Proudfoot, J. R. Drugs, leads, and drug-likeness: an analysis of some recently launched drugs. Bioorg. Med. Chem. Lett. 12, 1647-1650 (2002).
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1647-1650
-
-
Proudfoot, J.R.1
-
21
-
-
0035324944
-
Molecular complexity and its impact on the probability of finding leads for drug discovery
-
Hann, M. M., Leach, A. R. & Harper, G. Molecular complexity and its impact on the probability of finding leads for drug discovery. J. Chem, inf. Comput. Sci. 41, 856-864 (2001).
-
(2001)
J. Chem. Inf. Comput. Sci.
, vol.41
, pp. 856-864
-
-
Hann, M.M.1
Leach, A.R.2
Harper, G.3
-
22
-
-
0038732216
-
The right road to drug discovery? Fragment-based screening casts doubt on the Lipinski route
-
April
-
Carr, R. & Hann, M. The right road to drug discovery? Fragment-based screening casts doubt on the Lipinski route. Modern Drug Discov. April, 45-48 (2002)
-
(2002)
Modern Drug Discov.
, pp. 45-48
-
-
Carr, R.1
Hann, M.2
-
23
-
-
0000174195
-
Hydrogen bonding of carbonyl, ether, and ester oxygen atoms with alkanol hydroxyl groups
-
Lommerse, J. P. M., Price, S. L. & Taylor, R. Hydrogen bonding of carbonyl, ether, and ester oxygen atoms with alkanol hydroxyl groups. J. Comput. Chem. 18, 757-774(1997).
-
(1997)
J. Comput. Chem.
, vol.18
, pp. 757-774
-
-
Lommerse, J.P.M.1
Price, S.L.2
Taylor, R.3
-
24
-
-
0011639217
-
Oxygen and nitrogen in competitive situations: Which is the hydrogen-bond acceptor?
-
Böhm, H.-J., Brode, S., Hesse, U. & Klebe, G. Oxygen and nitrogen in competitive situations: which is the hydrogen-bond acceptor? Chem. Eur. J. 2, 1509-1513 (1996).
-
(1996)
Chem. Eur. J.
, vol.2
, pp. 1509-1513
-
-
Böhm, H.-J.1
Brode, S.2
Hesse, U.3
Klebe, G.4
-
25
-
-
0003800267
-
-
(eds Testa, B., van de Waterbeemd, H., Folkers, G. & Guy, R.) (Helvetica Chimica Acts and Wiley-VCH, Zurich, )
-
Kubinyi, H. in Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies (eds Testa, B., van de Waterbeemd, H., Folkers, G. & Guy, R.) 513-524 (Helvetica Chimica Acts and Wiley-VCH, Zurich, 2001).
-
(2001)
Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies
, pp. 513-524
-
-
Kubinyi, H.1
-
28
-
-
0003528267
-
The Double Helix: A Personal Account of the Discovery of the Structure of DNA
-
(Atheneum, New York, )
-
Watson, J. D. The Double Helix: A Personal Account of the Discovery of the Structure of DNA. (Atheneum, New York, 1968).
-
(1968)
-
-
Watson, J.D.1
-
29
-
-
20444468339
-
DNA
-
with (William Heinemann, London, )
-
Watson, J. D., with Berry, A. DNA. The Secret of Life, (William Heinemann, London, 2003).
-
(2003)
The Secret of Life
-
-
Watson, J.D.1
Berry, A.2
-
30
-
-
0242412669
-
-
Finding the flaws [online] (cited May 2003)
-
Finding the flaws [online] (cited May 2003) http://www.phy.cam,ac.uk/camphy/dna/dna13_1.htm (2003).
-
(2003)
-
-
-
31
-
-
0242580376
-
-
A working model! [online] (cited May 2003)
-
A working model! [online] (cited May 2003) http://www.phy.cam.ac.uk/camphy/dna/dna14_1.htm (2003).
-
(2003)
-
-
|