-
1
-
-
0141723577
-
Azithromycin for the secondary prevention of coronary heart disease events
-
O'Connor, C. M., Dunne, M. W., Pfeffer, M. A., Muhlestein, J. B., Yao, L., Gupta, S., Benner, R. J., Fisher, M. R., and Cook, T. D. (2003). Azithromycin for the secondary prevention of coronary heart disease events. Journal of the American Medical Association 290, 1459-1466.
-
(2003)
Journal of the American Medical Association
, vol.290
, pp. 1459-1466
-
-
O'Connor, C.M.1
Dunne, M.W.2
Pfeffer, M.A.3
Muhlestein, J.B.4
Yao, L.5
Gupta, S.6
Benner, R.J.7
Fisher, M.R.8
Cook, T.D.9
-
2
-
-
20244366215
-
Azithromycin for the secondary prevention of coronary events
-
Grayson, J. T., Kronmal, R. A., Jackson, L. A., Parisi, A. F., Muhlestein, J. B., Cohen, J. D., Rogers, W. J., Crouse, J. R., Borrowdale, S. L. Schron, E., and Knirsch, C. (2005). Azithromycin for the secondary prevention of coronary events. New England Journal of Medicine 352, 1637-1645.
-
(2005)
New England Journal of Medicine
, vol.352
, pp. 1637-1645
-
-
Grayson, J.T.1
Kronmal, R.A.2
Jackson, L.A.3
Parisi, A.F.4
Muhlestein, J.B.5
Cohen, J.D.6
Rogers, W.J.7
Crouse, J.R.8
Borrowdale, S.L.9
Schron, E.10
Knirsch, C.11
-
3
-
-
17244372856
-
Antibotic treatment of Chlamydia pneumoniae after acute coronary syndrome
-
Cannon, C. P., Braunwald, E., McCabe, C. H. Grayson, J. T., Muhlestein, B., Giugliano, R. P., Cairns, R., and Skene, A. M. (2005). Antibotic treatment of Chlamydia pneumoniae after acute coronary syndrome. New England Journal of Medicine 352, 1646-1654.
-
(2005)
New England Journal of Medicine
, vol.352
, pp. 1646-1654
-
-
Cannon, C.P.1
Braunwald, E.2
McCabe, C.H.3
Grayson, J.T.4
Muhlestein, B.5
Giugliano, R.P.6
Cairns, R.7
Skene, A.M.8
-
4
-
-
0033485711
-
Preventing coronary artery disease by lowering cholesterol levels; fifty years from bench to bedside
-
An excellent overview of the early history of this field is
-
An excellent overview of the early history of this field is: Steinberg, D., and Gotto, A. M. (1999). Preventing coronary artery disease by lowering cholesterol levels; fifty years from bench to bedside. Journal of the American Medical Association 282, 2043-2050.
-
(1999)
Journal of the American Medical Association
, vol.282
, pp. 2043-2050
-
-
Steinberg, D.1
Gotto, A.M.2
-
5
-
-
0004881473
-
The cholesterol myth
-
Moore, T. J. (1989). The cholesterol myth. The Atlantic Monthly 264, 37.
-
(1989)
The Atlantic Monthly
, vol.264
, pp. 37
-
-
Moore, T.J.1
-
6
-
-
0021354536
-
Epidemiology of coronary heart disease: The Framingham study
-
Castelli, W. P. (1984). Epidemiology of coronary heart disease: The Framingham study. American Journal of Medicine 76 (Suppl 2A), 4-12.
-
(1984)
American Journal of Medicine
, vol.76
, Issue.SUPPL.2
, pp. 4-12
-
-
Castelli, W.P.1
-
7
-
-
0021350001
-
The Lipid Research Clinics Coronary Primary Prevention Trial Results
-
Lipid Research Clinics Program
-
Lipid Research Clinics Program (1984). The Lipid Research Clinics Coronary Primary Prevention Trial Results. Journal of the American Medical Association 251, 351-374.
-
(1984)
Journal of the American Medical Association
, vol.251
, pp. 351-374
-
-
-
8
-
-
0022117329
-
Lowering blood cholesterol to prevent heart disease: NIH Consensus Development statement
-
NIH Consensus Development Conference
-
NIH Consensus Development Conference (1985). Lowering blood cholesterol to prevent heart disease: NIH Consensus Development statement. Nutritional Reviews 43, 283-291.
-
(1985)
Nutritional Reviews
, vol.43
, pp. 283-291
-
-
-
9
-
-
0038004785
-
Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors
-
Tolbert, J. A. (2003). Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nature Reviews, Drug Discovery 2, 517-526.
-
(2003)
Nature Reviews, Drug Discovery
, vol.2
, pp. 517-526
-
-
Tolbert, J.A.1
-
10
-
-
84957736952
-
-
These patients are known to have heterozygous familial hypercholesterolemia. This is a relatively common genetic disorder occurring in about 0.2% of the population. These patients have reduced ability for their liver to remove LDL cholesterol from the blood. As a result, they have LDL levels on the order of 300-400 mg/dL and are at the risk of premature heart disease
-
These patients are known to have heterozygous familial hypercholesterolemia. This is a relatively common genetic disorder occurring in about 0.2% of the population. These patients have reduced ability for their liver to remove LDL cholesterol from the blood. As a result, they have LDL levels on the order of 300-400 mg/dL and are at the risk of premature heart disease.
-
-
-
-
11
-
-
0022549920
-
A receptor mediated pathway for cholesterol homeostasis
-
Brown, M. S., and Goldstein, J. L. (1986). A receptor mediated pathway for cholesterol homeostasis. Science 232, 34-47.
-
(1986)
Science
, vol.232
, pp. 34-47
-
-
Brown, M.S.1
Goldstein, J.L.2
-
12
-
-
0027987849
-
Trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian simvastatin survival study (4S)
-
Scandinavian Simvastatin Survival Study Group Randomized
-
Scandinavian Simvastatin Survival Study Group Randomized (1994). Trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian simvastatin survival study (4S). The Lancet 344, 1383-1389.
-
(1994)
The Lancet
, vol.344
, pp. 1383-1389
-
-
-
13
-
-
84970843865
-
Lower patients'cholesterol now
-
Oliver, M., Poole-Wilson, P., Shepherd, J., and Tikkanen, M. J. (1995). Lower patients'cholesterol now! British Medical Journal 310, 2180-1281.
-
(1995)
British Medical Journal
, vol.310
, pp. 2180-1281
-
-
Oliver, M.1
Poole-Wilson, P.2
Shepherd, J.3
Tikkanen, M.J.4
-
14
-
-
84889873524
-
-
Zetia ® is a registered trademark of MSP Marketing Services © LLD
-
Zetia ® is a registered trademark of MSP Marketing Services © LLD.
-
-
-
-
15
-
-
84889798423
-
-
Vytorin ® is a registered trademark of MSP Marketing Services © LLD
-
Vytorin ® is a registered trademark of MSP Marketing Services © LLD.
-
-
-
-
16
-
-
84889784297
-
-
IMPROVE-IT, as well as other Vytorin studies, are summarized at
-
IMPROVE-IT, as well as other Vytorin studies, are summarized at www.clinicaltrials.gov.
-
-
-
-
17
-
-
84889769625
-
Merck and Schering-Plough respond to issues raised about ENHANCE clinical trial
-
Press Release, January 14
-
"Merck and Schering-Plough respond to issues raised about ENHANCE clinical trial" Press Release, January 14, 2008.
-
(2008)
-
-
-
18
-
-
41649107358
-
Simvastatin with or without ezetimibe in familial hypercholesterolemia
-
Kastelein, J. J. P., Akdim, F., Stoes, E. S. G., Zwinderman, A. H., Bots, M. L., Stalenhoef, A. F. H., Visseren, F. L. J., Sijbrands, E. J. G., Trip, M. D., Stein, E. A., GauDet, D., Duivenvoorden, R., Veltri, E. P., Marais, A. D., and De Groot, E. (2008). Simvastatin with or without ezetimibe in familial hypercholesterolemia. New England Journal of Medicine 358, 1431-1443.
-
(2008)
New England Journal of Medicine
, vol.358
, pp. 1431-1443
-
-
Kastelein, J.J.P.1
Akdim, F.2
Stoes, E.S.G.3
Zwinderman, A.H.4
Bots, M.L.5
Stalenhoef, A.F.H.6
Visseren, F.L.J.7
Sijbrands, E.J.G.8
Trip, M.D.9
Stein, E.A.10
GauDet, D.11
Duivenvoorden, R.12
Veltri, E.P.13
Marais, A.D.14
De Groot, E.15
-
19
-
-
84889818451
-
Cholesterol as a danger has its skeptics
-
January 17
-
Berenson, A. (2008). Cholesterol as a danger has its skeptics. New York Times, January 17.
-
(2008)
New York Times
-
-
Berenson, A.1
-
20
-
-
38749130444
-
Do cholesterol drugs do any good?
-
January 28
-
Carey, J. (2008). Do cholesterol drugs do any good? Business Week, January 28.
-
(2008)
Business Week
-
-
Carey, J.1
-
22
-
-
84889826041
-
-
These data can be reviewed on the CDC website
-
These data can be reviewed on the CDC website: www.cdc.gov.
-
-
-
-
23
-
-
84889836278
-
An innovative drug industry?
-
The Washington Post, November 16
-
Lansbury, P. (2003). An innovative drug industry? Well, no. The Washington Post, November 16.
-
(2003)
Well
-
-
Lansbury, P.1
-
24
-
-
8344266043
-
The economics of follow-on drug research and development. Trends in entry rates and timing of development
-
DiMasi, J. A., and Paquette, C. (2004). The economics of follow-on drug research and development. Trends in entry rates and timing of development. Pharmacoeconomics 22 (Suppl 2), 1-14.
-
(2004)
Pharmacoeconomics
, vol.22
, Issue.SUPPL.2
, pp. 1-14
-
-
DiMasi, J.A.1
Paquette, C.2
-
25
-
-
0036345274
-
Atorvastatin in low-density lioprotein aphaeresis-treated patients with homozygous and heterozygous familial hypecholesterolemia
-
Goldammer, A., Wiltschnig, S., Heinz, G., Jansen, M., Stulnig, T., Hrl, W. H., and Derfler, K. (2002). Atorvastatin in low-density lioprotein aphaeresis-treated patients with homozygous and heterozygous familial hypecholesterolemia. Metabolism 51, 976-980.
-
(2002)
Metabolism
, vol.51
, pp. 976-980
-
-
Goldammer, A.1
Wiltschnig, S.2
Heinz, G.3
Jansen, M.4
Stulnig, T.5
Hrl, W.H.6
Derfler, K.7
-
26
-
-
15944410609
-
Intensive lipid lowering with atorvastatin in patients with stable coronary disease
-
for the Treating to New Targets (TNT) Investigators
-
LaRosa, J. C., Grundy, S. M., Waters, D. D., Shear, C., Bater, P., Fruchat, J.-C., Gotto, A. M., Green, H., Kastelein, J. J. P., Sheherd, J., and Wenger, N. K., for the Treating to New Targets (TNT) Investigators. (2005). Intensive lipid lowering with atorvastatin in patients with stable coronary disease. New England Journal of Medicine 352 (14), 1425-1435.
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.14
, pp. 1425-1435
-
-
LaRosa, J.C.1
Grundy, S.M.2
Waters, D.D.3
Shear, C.4
Bater, P.5
Fruchat, J.-C.6
Gotto, A.M.7
Green, H.8
Kastelein, J.J.P.9
Sheherd, J.10
Wenger, N.K.11
-
27
-
-
4344683381
-
Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomized placebo-controlled trial
-
Colhoun, H. M., Betteridge, D. J., Durrington, P. N., Hitman, G. A., Neil, A. W., Livingston, S. J., Thompson, J. J., Mackness, M. I., Charlton-Menys, V., and Fuller, J. H. (2004). Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomized placebo-controlled trial. The Lancet 364, 685-696.
-
(2004)
The Lancet
, vol.364
, pp. 685-696
-
-
Colhoun, H.M.1
Betteridge, D.J.2
Durrington, P.N.3
Hitman, G.A.4
Neil, A.W.5
Livingston, S.J.6
Thompson, J.J.7
Mackness, M.I.8
Charlton-Menys, V.9
Fuller, J.H.10
-
28
-
-
0037420492
-
Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average to lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial
-
Sever, P. S., Dahlof, B., Poulter, N. R., Wedel, H., Beevers, G., Caulfield, M., Collins, R., Kjeldsen, S. E., Kristinsson, A., McInnes, G. T., Mehlsen, J., Nieminen, M., O'Brien, E., and Ostergren, J. (2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average to lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial. The Lancet 361, 1149-1158.
-
(2003)
The Lancet
, vol.361
, pp. 1149-1158
-
-
Sever, P.S.1
Dahlof, B.2
Poulter, N.R.3
Wedel, H.4
Beevers, G.5
Caulfield, M.6
Collins, R.7
Kjeldsen, S.E.8
Kristinsson, A.9
McInnes, G.T.10
Mehlsen, J.11
Nieminen, M.12
O'Brien, E.13
Ostergren, J.14
-
29
-
-
1942542158
-
Hypothesis: Atorvastatin has pleiotropic effects that translate into early clinical benefits on cardiovascular disease
-
Novela, C., and Hennekens, C. H. (2004). Hypothesis: Atorvastatin has pleiotropic effects that translate into early clinical benefits on cardiovascular disease. Journal of Cardiovascular Pharmacology and Therapeutics 9, 61-63.
-
(2004)
Journal of Cardiovascular Pharmacology and Therapeutics
, vol.9
, pp. 61-63
-
-
Novela, C.1
Hennekens, C.H.2
-
30
-
-
40949135645
-
Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial funciton and exercise capacity
-
Castro, P. F., Miranda, R., Verdejo, H. E., Greig, D., Gabrielli, L. A., Alcaino, H., Chiong, M., Bustos, C., Garcia, L., Mellado, R., Vukasovic, J. L., Godoy, I., and Lavandero, S. (2008). Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial funciton and exercise capacity. Journal of Heart and Lung Transplantation 27, 435-441.
-
(2008)
Journal of Heart and Lung Transplantation
, vol.27
, pp. 435-441
-
-
Castro, P.F.1
Miranda, R.2
Verdejo, H.E.3
Greig, D.4
Gabrielli, L.A.5
Alcaino, H.6
Chiong, M.7
Bustos, C.8
Garcia, L.9
Mellado, R.10
Vukasovic, J.L.11
Godoy, I.12
Lavandero, S.13
-
31
-
-
3142729178
-
Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
-
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, Jr., H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, Jr., S. C., and Stone, N. J. (2004). Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation 110, 227-239.
-
(2004)
Circulation
, vol.110
, pp. 227-239
-
-
Grundy, S.M.1
Cleeman, J.I.2
Merz, C.N.B.3
Brewer Jr, H.B.4
Clark, L.T.5
Hunninghake, D.B.6
Pasternak, R.C.7
Smith Jr, S.C.8
Stone, N.J.9
-
32
-
-
2442674610
-
Heart Disease and Stroke Statistics
-
American Heart Association, Update
-
American Heart Association, Heart Disease and Stroke Statistics, 2005 Update.
-
(2005)
-
-
-
33
-
-
0035924665
-
American Journal of Cardiology
-
Franceschini, G. (2000). American Journal of Cardiology 88 (Suppl), 9-13.
-
(2000)
, vol.88
, Issue.SUPPL.
, pp. 9-13
-
-
Franceschini, G.1
-
34
-
-
0025104275
-
Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation
-
Inazu, A., Brown, M. L., Hesler, C. B., Agellon, L. B., Koizumi, J., Takata, K., Maruhama, Y., Mabuchi, H., and Tall, A. R. (1990). Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. New England Journal of Medicine 323, 1234-1238.
-
(1990)
New England Journal of Medicine
, vol.323
, pp. 1234-1238
-
-
Inazu, A.1
Brown, M.L.2
Hesler, C.B.3
Agellon, L.B.4
Koizumi, J.5
Takata, K.6
Maruhama, Y.7
Mabuchi, H.8
Tall, A.R.9
-
35
-
-
20544454535
-
Torcetrapib and atorvastatin-Should marketing drive the research agenda?
-
Avorn, J. (2005). Torcetrapib and atorvastatin-Should marketing drive the research agenda? New England Journal of Medicine 352, 2573-2576.
-
(2005)
New England Journal of Medicine
, vol.352
, pp. 2573-2576
-
-
Avorn, J.1
-
37
-
-
0003820166
-
Annual Report
-
Pfizer
-
Pfizer 2001 Annual Report, page 17.
-
(2001)
, pp. 17
-
-
-
38
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DiMasi, J. A., Hansen, R. W., and Grabowski, H. G. (2003). The price of innovation: New estimates of drug development costs. Journal of Health Economics 22, 151-185.
-
(2003)
Journal of Health Economics
, vol.22
, pp. 151-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
39
-
-
79954135655
-
The Today Show
-
September 2
-
"The Today Show," September 2, 2004.
-
(2004)
-
-
-
40
-
-
41149128233
-
Surrogate end points and FDA approval. A tale of 2 lipid-altering drugs
-
Psaty, B. M., and Lumley, T. (2008). Surrogate end points and FDA approval. A tale of 2 lipid-altering drugs. Journal of the American Medical Association 299, 1474-1476.
-
(2008)
Journal of the American Medical Association
, vol.299
, pp. 1474-1476
-
-
Psaty, B.M.1
Lumley, T.2
-
41
-
-
34447265547
-
Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): A randomized, double-blind trial
-
Kastelein, J. J., Bots, M. L., Visseren, F. L., Evans, G. W., Riley, W. A., Reykin, J. H., Tegeler, C. H., Shear, C. L., Duggan, W. T., Vicari, R. M., and Grobbee, D. E. Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): A randomized, double-blind trial. The Lancet 370, 153-160.
-
The Lancet
, vol.370
, pp. 153-160
-
-
Kastelein, J.J.1
Bots, M.L.2
Visseren, F.L.3
Evans, G.W.4
Riley, W.A.5
Reykin, J.H.6
Tegeler, C.H.7
Shear, C.L.8
Duggan, W.T.9
Vicari, R.M.10
Grobbee, D.E.11
-
42
-
-
34447268741
-
The Lancet
-
Mazzone, T. (2007). The Lancet 370, 107-108.
-
(2007)
, vol.370
, pp. 107-108
-
-
Mazzone, T.1
-
43
-
-
34247241088
-
Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
-
for the RADIANCE Investigators
-
Kastelein, J. J., van Leuven, S. I., Burgess, L., Evans, G. W., Kiuvenhoven, J. A., Barter, P. J., Revkin, J. H., Grobbee, D. E., Riley, W. A., Shear, C. L., Duggan, W. T., and Bots, M. L., for the RADIANCE Investigators (2007). Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. New England Journal of Medicine 356, 1620-1630.
-
(2007)
New England Journal of Medicine
, vol.356
, pp. 1620-1630
-
-
Kastelein, J.J.1
Van Leuven, S.I.2
Burgess, L.3
Evans, G.W.4
Kiuvenhoven, J.A.5
Barter, P.J.6
Revkin, J.H.7
Grobbee, D.E.8
Riley, W.A.9
Shear, C.L.10
Duggan, W.T.11
Bots, M.L.12
-
44
-
-
34047106220
-
Effect of torcetrapib on the progression of coronary atherosclerosis
-
for the ILLUSTRATE Investigators
-
Nissen, S. E., Tardif, J.-C., Nicholls, S. J., Revkin, J. H., Shear, C. L., Duggan, W. T., Ruzyllo, W., Bachinsky, W. B., Lasala, G. P., and Tuzcu, E. M., for the ILLUSTRATE Investigators (2007). Effect of torcetrapib on the progression of coronary atherosclerosis. New England Journal of Medicine 356, 1304-1315.
-
(2007)
New England Journal of Medicine
, vol.356
, pp. 1304-1315
-
-
Nissen, S.E.1
Tardif, J.-C.2
Nicholls, S.J.3
Revkin, J.H.4
Shear, C.L.5
Duggan, W.T.6
Ruzyllo, W.7
Bachinsky, W.B.8
Lasala, G.P.9
Tuzcu, E.M.10
-
45
-
-
70349497214
-
Medical News Today
-
April 3
-
Medical News Today, April 3, 2007.
-
(2007)
-
-
-
46
-
-
79954135655
-
The Today Show
-
September 2
-
"The Today Show," September 2, 2004.
-
(2004)
-
-
-
47
-
-
84889850625
-
General Public
-
Consensus Research Stakeholder Value Research, Phase II, July
-
Consensus Research Stakeholder Value Research, General Public, Phase II, July 2003.
-
(2003)
-
-
-
48
-
-
84889811694
-
NIH, Report to Congress on Request to Protect Taxpayers Interests
-
Department of Human and Health Services, July
-
Department of Human and Health Services, NIH, Report to Congress on Request to Protect Taxpayers Interests, July 2001.
-
(2001)
-
-
-
49
-
-
84889860060
-
NIH, Report to Congress on Affordability of Inventions and Products
-
Department of Human and Health Services, July
-
Department of Human and Health Services, NIH, Report to Congress on Affordability of Inventions and Products, July 2004.
-
(2004)
-
-
-
51
-
-
62549088346
-
The truth about drug innovation: Thirty-five summary case histories on private sector contributions to pharmaceutical science
-
Manhattan Institute for Policy Research, Policy Report, June 2008
-
Zycher, B., DiMasi, J. A., and Milne, C.-P. (2008). The truth about drug innovation: Thirty-five summary case histories on private sector contributions to pharmaceutical science, Manhattan Institute for Policy Research, Policy Report No. 6, June 2008, www.manhattan-institute.org/html/mpr_06.htm.
-
(2008)
, Issue.6
-
-
Zycher, B.1
DiMasi, J.A.2
Milne, C.-P.3
-
52
-
-
0028301958
-
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes
-
Kawamura, M., McVicar, D. W., Johnston, J. A., Blake, T. B., Chen, Y., Lal, B. K., Lloyd, A. R., Kelvin, D. J., Staples, J. E., Ortaldo, J. R., and O'Shea, J. J. (1994). Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proceedings of the National Academy of Science 91, 6374-6378.
-
(1994)
Proceedings of the National Academy of Science
, vol.91
, pp. 6374-6378
-
-
Kawamura, M.1
McVicar, D.W.2
Johnston, J.A.3
Blake, T.B.4
Chen, Y.5
Lal, B.K.6
Lloyd, A.R.7
Kelvin, D.J.8
Staples, J.E.9
Ortaldo, J.R.10
O'Shea, J.J.11
-
53
-
-
18244393495
-
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: Structural implication for Janus kinases
-
Zhou, Y.-J., Chen, M., Cusack, N. A., Kimmell, L. H., Magnuson, K. S., Boyd, J. G., Lin, W., Roberts, J. L., Lengi, A., Buckley, R. H., Geahlen, R. L., Candott, F., Gadina, M., Changelian, P. S., and O'Shea, J. J. (2001). Unexpected effects of FERM domain mutations on catalytic activity of Jak3: Structural implication for Janus kinases. Cell 8, 959-969.
-
(2001)
Cell
, vol.8
, pp. 959-969
-
-
Zhou, Y.-J.1
Chen, M.2
Cusack, N.A.3
Kimmell, L.H.4
Magnuson, K.S.5
Boyd, J.G.6
Lin, W.7
Roberts, J.L.8
Lengi, A.9
Buckley, R.H.10
Geahlen, R.L.11
Candott, F.12
Gadina, M.13
Changelian, P.S.14
O'Shea, J.J.15
-
54
-
-
0031444188
-
Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
-
Zhou, Y.-J., Hanson, E. P., Chen, Y.-Q., Magnuson, K., Chen, M., Swann, G., Wange, R. L., O'Shea, J. J., and Changelian, P. S. (1997). Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proceedings of the National Academy of Science 94, 13850-13855.
-
(1997)
Proceedings of the National Academy of Science
, vol.94
, pp. 13850-13855
-
-
Zhou, Y.-J.1
Hanson, E.P.2
Chen, Y.-Q.3
Magnuson, K.4
Chen, M.5
Swann, G.6
Wange, R.L.7
O'Shea, J.J.8
Changelian, P.S.9
-
55
-
-
0027751556
-
Interleukin-2 receptor γ chain: A functional component of the interleukin-7 receptor
-
Noguchi, M., Nakamura, Y., Russell, S. M., Ziegler, S. F., Tsang, M., Cao, X., and Leonard, W. J. (1993). Interleukin-2 receptor γ chain: A functional component of the interleukin-7 receptor. Science 262, 1877-1880.
-
(1993)
Science
, vol.262
, pp. 1877-1880
-
-
Noguchi, M.1
Nakamura, Y.2
Russell, S.M.3
Ziegler, S.F.4
Tsang, M.5
Cao, X.6
Leonard, W.J.7
-
56
-
-
0027787877
-
Interleukin-2 receptor γ chain: A functional component of the interleukin-4 receptor
-
Russell, S. M., Keegan, A. D., Harada, N., Nakamura, Y., Noguchi, M., Leland, P., Friedmann, M. C., Miyajima, A., Puri, R. K., Paul, W. E., and Leonard, W. J. (1993). Interleukin-2 receptor γ chain: A functional component of the interleukin-4 receptor. Science 262, 1880-1883.
-
(1993)
Science
, vol.262
, pp. 1880-1883
-
-
Russell, S.M.1
Keegan, A.D.2
Harada, N.3
Nakamura, Y.4
Noguchi, M.5
Leland, P.6
Friedmann, M.C.7
Miyajima, A.8
Puri, R.K.9
Paul, W.E.10
Leonard, W.J.11
-
57
-
-
0028857954
-
Mutation of JAK3 in a patient with SCID: Essential role of JAK3 in lymphoid development
-
Russell, S. M., Tayebi, N., Nakajima, H., Riedy, M. C., Roberts J. L., Aman, M. J., Migone, T.-S., Noguchi, M., Markert, M. L., Buckley, R. H., O'Shea, J. J., and Leonard, W. J. (1995). Mutation of JAK3 in a patient with SCID: Essential role of JAK3 in lymphoid development. Science 270, 797-800.
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
Tayebi, N.2
Nakajima, H.3
Riedy, M.C.4
Roberts, J.L.5
Aman, M.J.6
Migone, T.-S.7
Noguchi, M.8
Markert, M.L.9
Buckley, R.H.10
O'Shea, J.J.11
Leonard, W.J.12
-
58
-
-
0242332186
-
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
-
Borie, D. C., Changelian, P. S., et al. (2003). Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science 302, 875-878.
-
(2003)
Science
, vol.302
, pp. 875-878
-
-
Borie, D.C.1
Changelian, P.S.2
-
59
-
-
0028169466
-
Effects of limiting Medicaid drug-reimbursement benefits on the use of psychotropic agents and acute mental health services by patients with schizophrenia
-
Soumerai, S. B., McLaughlin, T. J., Ross-Degnan, D., Casteris, C. S., and Bollini, P. (1994). Effects of limiting Medicaid drug-reimbursement benefits on the use of psychotropic agents and acute mental health services by patients with schizophrenia. New England Journal of Medicine 331, 650-655.
-
(1994)
New England Journal of Medicine
, vol.331
, pp. 650-655
-
-
Soumerai, S.B.1
McLaughlin, T.J.2
Ross-Degnan, D.3
Casteris, C.S.4
Bollini, P.5
-
60
-
-
0037849900
-
The Asheville Project: Long-term clinical and economic outcomes of a community pharmacy diabetes care system
-
Cranor, C. W., Bunting, B. A., and Christensen, D. B. (2003). The Asheville Project: Long-term clinical and economic outcomes of a community pharmacy diabetes care system. Journal of the American Pharmacists Association 43 (2), 173-184.
-
(2003)
Journal of the American Pharmacists Association
, vol.43
, Issue.2
, pp. 173-184
-
-
Cranor, C.W.1
Bunting, B.A.2
Christensen, D.B.3
-
61
-
-
0035869519
-
Expenditures for the care of HIV-infected patients in the era of highly active antiretroviral therapy
-
Bozzette, S. A., Joyce, G., McCaffery, D. F., Leibowitz, A. A., Morton, S. C., Berry, S. H., Rastegar, A., Timberlake, D., Shapiro, M. F., and Goldman, D. P. (2001). Expenditures for the care of HIV-infected patients in the era of highly active antiretroviral therapy. New England Journal of Medicine 334, 817-823.
-
(2001)
New England Journal of Medicine
, vol.334
, pp. 817-823
-
-
Bozzette, S.A.1
Joyce, G.2
McCaffery, D.F.3
Leibowitz, A.A.4
Morton, S.C.5
Berry, S.H.6
Rastegar, A.7
Timberlake, D.8
Shapiro, M.F.9
Goldman, D.P.10
-
62
-
-
4644347571
-
A Counterblaste to Tobacco
-
King James I. (1604). A Counterblaste to Tobacco.
-
(1604)
-
-
King James, I.1
-
63
-
-
33846858426
-
Pharmacological profile of the α 4 β 2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid
-
Rollema, H., Chambers, L. K., Coe, J. W., Glowa, J., Hurst, R. S., Lebel, L. A., Lu, Y., Mansbach, R. S., Mather, R. J., Rovetti, C. C., Sands, S. B., Schaeffer, E., Schulz, D. W., Tingley, F. D., III, and Williams, K. E. (2007). Pharmacological profile of the α 4 β 2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid. Neuropharmacology 52, 985-994.
-
(2007)
Neuropharmacology
, vol.52
, pp. 985-994
-
-
Rollema, H.1
Chambers, L.K.2
Coe, J.W.3
Glowa, J.4
Hurst, R.S.5
Lebel, L.A.6
Lu, Y.7
Mansbach, R.S.8
Mather, R.J.9
Rovetti, C.C.10
Sands, S.B.11
Schaeffer, E.12
Schulz, D.W.13
Tingley III, F.D.14
Williams, K.E.15
-
64
-
-
20844441945
-
Varenicline: An α 4 β 2 nicotinic receptor partial agonist for smoking cessation
-
Coe, J. W., Brooks, P. R., Vetelino, M. G., Witz, M. C., Arnold, E. P., Huang, J., Sands, S. B., Davis, T. I., Lebel, L. A., Fox, C. B., Shrikhande, A., Heym, J. H., Schaeffer, E., Rollema, H., Lu, Y., Mansbach, R. S., Chambers, L. K., Rovetti, C. C., Schulz, D. W., Tingley, D., III, and O'Neill, B. T. (2005). Varenicline: An α 4 β 2 nicotinic receptor partial agonist for smoking cessation. Journal of Medicinal Chemistry 48, 3474-3477.
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, pp. 3474-3477
-
-
Coe, J.W.1
Brooks, P.R.2
Vetelino, M.G.3
Witz, M.C.4
Arnold, E.P.5
Huang, J.6
Sands, S.B.7
Davis, T.I.8
Lebel, L.A.9
Fox, C.B.10
Shrikhande, A.11
Heym, J.H.12
Schaeffer, E.13
Rollema, H.14
Lu, Y.15
Mansbach, R.S.16
Chambers, L.K.17
Rovetti, C.C.18
Schulz, D.W.19
Tingley III, F.D.20
O'Neill, B.T.21
more..
-
65
-
-
60749113967
-
FDA Issues Public Health Advisory on Chantix
-
FDA News, February 1, 2008
-
FDA News (2008). FDA Issues Public Health Advisory on Chantix (February 1, 2008) www.fda.gov/cder/drug/infopage/varenicline/default.htm.
-
(2008)
-
-
-
66
-
-
84889818445
-
$ 480 for quit pill
-
Daily Telegraph, November 13
-
Dunlevy, S. (2007). $ 480 for quit pill. Daily Telegraph, November 13.
-
(2007)
-
-
Dunlevy, S.1
-
67
-
-
34547747293
-
Science Business
-
Harvard Business School Press, Boston
-
Pisano, G. P. (2006). Science Business, Harvard Business School Press, Boston.
-
(2006)
-
-
Pisano, G.P.1
-
68
-
-
33846464368
-
Centers for Disease Control
-
National Center for Health Statistics, Available at
-
National Center for Health Statistics, Centers for Disease Control Available at http://www.cdc.gov/ nchs.
-
-
-
-
69
-
-
15844419153
-
Identification of a major co-receptor for primary isolates of HIV-1
-
Deng, H. K., Liu, R., Ellmeier, W., Choe S., Unutmaz, D., Burkhart, M., DiMarzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. G., Peiper, S. C., Schall, T. J., Littman, D. R., and Landau, N. R. (1996). Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661-666.
-
(1996)
Nature
, vol.381
, pp. 661-666
-
-
Deng, H.K.1
Liu, R.2
Ellmeier, W.3
Choe, S.4
Unutmaz, D.5
Burkhart, M.6
DiMarzio, P.7
Marmon, S.8
Sutton, R.E.9
Hill, C.M.10
Davis, C.G.11
Peiper, S.C.12
Schall, T.J.13
Littman, D.R.14
Landau, N.R.15
-
70
-
-
84889824098
-
How horrors of the plague made Europe safer from AIDS scourge
-
(London), March 11
-
Jenkins, R. (2005). How horrors of the plague made Europe safer from AIDS scourge. The Times (London), March 11.
-
(2005)
The Times
-
-
Jenkins, R.1
-
71
-
-
0345166037
-
Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ 32 HIV-resistance allele
-
Galvani, A. P., and Slatkin, M. (2003). Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ 32 HIV-resistance allele. Proceedings of the National Academy of Sciences 100, 15276-15279.
-
(2003)
Proceedings of the National Academy of Sciences
, vol.100
, pp. 15276-15279
-
-
Galvani, A.P.1
Slatkin, M.2
-
73
-
-
27644510382
-
Maraviroc (UK-427,857), a potent, orally bioavailable and selective small molecule inhibitor of a chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
-
Dorr, P., Westby, M., Dobbs, S., Griffin, P., Irvine, B., Macartney, M., Mori, J., Rickett, G., Smith-Burchenell, C., Napier, C., Webster, R., Armour, D., Price, D., Stammen, B., Wood, A., and Perros, M. (2005). Maraviroc (UK-427,857), a potent, orally bioavailable and selective small molecule inhibitor of a chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrobial Agents and Chemotherapy 49, 4721-4732.
-
(2005)
Antimicrobial Agents and Chemotherapy
, vol.49
, pp. 4721-4732
-
-
Dorr, P.1
Westby, M.2
Dobbs, S.3
Griffin, P.4
Irvine, B.5
Macartney, M.6
Mori, J.7
Rickett, G.8
Smith-Burchenell, C.9
Napier, C.10
Webster, R.11
Armour, D.12
Price, D.13
Stammen, B.14
Wood, A.15
Perros, M.16
-
74
-
-
84889843468
-
-
In Europe and other parts of the world, Selzentry is sold as Celsentri
-
In Europe and other parts of the world, Selzentry is sold as Celsentri.
-
-
-
-
75
-
-
84889767340
-
-
www.Incyte.com/ProductPipeline.
-
-
-
-
76
-
-
0037070782
-
Selling sickness: The pharmaceutical industry and disease mongering
-
Moynihan, R., Heath, I., and Henry, D. (2002). Selling sickness: The pharmaceutical industry and disease mongering. British Medical Journal 324, 886-891.
-
(2002)
British Medical Journal
, vol.324
, pp. 886-891
-
-
Moynihan, R.1
Heath, I.2
Henry, D.3
-
77
-
-
67650833029
-
Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Medicines and Hooked the Nation on Prescription Drugs
-
Farrar, Straus and Giroux, New York
-
Petersen, M. (2008). Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Medicines and Hooked the Nation on Prescription Drugs. Farrar, Straus and Giroux, New York.
-
(2008)
-
-
Petersen, M.1
-
78
-
-
13444258250
-
Overdosed America: The Broken Promise of American Medicine
-
HarperCollins, New York
-
Abramson, J. (2004). Overdosed America: The Broken Promise of American Medicine, HarperCollins, New York.
-
(2004)
-
-
Abramson, J.1
-
79
-
-
0141722482
-
Overdose: The Case Against the Drug Companies
-
Penguin, New York
-
Cohen, J. S. (2001). Overdose: The Case Against the Drug Companies, Penguin, New York.
-
(2001)
-
-
Cohen, J.S.1
-
80
-
-
4644249070
-
The burden of illness of irritable bowel syndrome: Current challenges and hope for the future
-
Hulisz, D. (2004). The burden of illness of irritable bowel syndrome: Current challenges and hope for the future. Journal of Managed Care Pharmacy 10, 299-309.
-
(2004)
Journal of Managed Care Pharmacy
, vol.10
, pp. 299-309
-
-
Hulisz, D.1
-
81
-
-
0037050366
-
Post-traumatic stress disorder
-
Yehuda, R. (2002). Post-traumatic stress disorder. New England Journal of Medicine 346, 108-114.
-
(2002)
New England Journal of Medicine
, vol.346
, pp. 108-114
-
-
Yehuda, R.1
-
82
-
-
0004286870
-
Stress Response Syndromes
-
Aronson, Inc., New York
-
Horowitz, M. (1976). Stress Response Syndromes, Aronson, Inc., New York.
-
(1976)
-
-
Horowitz, M.1
-
83
-
-
84870462770
-
Diagnostic Statistical Manual of Mental Disorders
-
4th Edition: DSM-IV, American Psychiatric Association, Washington, DC
-
Diagnostic Statistical Manual of Mental Disorders, 4th Edition: DSM-IV, American Psychiatric Association, Washington, DC. 1994.
-
(1994)
-
-
-
84
-
-
0035022587
-
Multicenter, Double-blind comparison of Sertraline and placebo in the treatment of posttraumatic stress disorder
-
Davidson, J. R. T., Rothbaum, B. O., van derKolk, B. A., Sikes, C. R., and Farfel, G. M. (2001). Multicenter, Double-blind comparison of Sertraline and placebo in the treatment of posttraumatic stress disorder. Archives of General Psychiatry 58, 485-492.
-
(2001)
Archives of General Psychiatry
, vol.58
, pp. 485-492
-
-
Davidson, J.R.T.1
Rothbaum, B.O.2
Van DerKolk, B.A.3
Sikes, C.R.4
Farfel, G.M.5
-
85
-
-
0034639954
-
Efficacy and safety of Sertraline treatment of posttraumatic stress disorder
-
Brady, K., Pearlstein T., Asnis, G. M., Baker, D., Rothbaum, B., Sikes, C. R., and Farfel, G. M. (2000). Efficacy and safety of Sertraline treatment of posttraumatic stress disorder. Journal of the American Medical Association 283, 1837-1844.
-
(2000)
Journal of the American Medical Association
, vol.283
, pp. 1837-1844
-
-
Brady, K.1
Pearlstein, T.2
Asnis, G.M.3
Baker, D.4
Rothbaum, B.5
Sikes, C.R.6
Farfel, G.M.7
-
86
-
-
34249698975
-
Randomized double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting
-
Friedman, M. J., Marmar, C. R., Baker, D. G., Sikes, C. R., and Farfel, G. M. (2007). Randomized double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting. Journal of Clinical Psychiatry 68, 711-720.
-
(2007)
Journal of Clinical Psychiatry
, vol.68
, pp. 711-720
-
-
Friedman, M.J.1
Marmar, C.R.2
Baker, D.G.3
Sikes, C.R.4
Farfel, G.M.5
-
87
-
-
42949167213
-
Gain against the pain. Fibromyalgia knowledge and treatment have improved
-
October 18
-
Hobson, K. (2007). Gain against the pain. Fibromyalgia knowledge and treatment have improved. US News and World Report, October 18.
-
(2007)
US News and World Report
-
-
Hobson, K.1
-
88
-
-
23444450943
-
Fibromyalgia syndrome: Review of clinical presentation, pathogenesis, outcome measures, and treatment
-
Mease, P. (2005). Fibromyalgia syndrome: Review of clinical presentation, pathogenesis, outcome measures, and treatment. Journal of Rheumatology 32 (Suppl 75), 6-21.
-
(2005)
Journal of Rheumatology
, vol.32
, Issue.SUPPL.75
, pp. 6-21
-
-
Mease, P.1
-
89
-
-
37649021435
-
Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM) trial: A six-month, double-blind, placebo-controlled trial of treatment with pregabalin
-
Crofford, L., Simpson, S., Young, J., Haig, G., and Barrett, J. (2007). Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM) trial: A six-month, double-blind, placebo-controlled trial of treatment with pregabalin. Journal of Pain 8 (Suppl 1), S 24.
-
(2007)
Journal of Pain
, vol.8
, Issue.SUPPL.1
-
-
Crofford, L.1
Simpson, S.2
Young, J.3
Haig, G.4
Barrett, J.5
-
90
-
-
84889849756
-
List of problem prescription drugs is growing
-
Newsday, January 21
-
Ricks, D. (2008). List of problem prescription drugs is growing. Newsday, January 21.
-
(2008)
-
-
Ricks, D.1
-
91
-
-
36849061688
-
Over the counter but no longer under the radar-Pediatric cough and cold medications
-
Sharfstein, J. M., North, M., and Serwint, J. R. (2007). Over the counter but no longer under the radar-Pediatric cough and cold medications. New England Journal of Medicine 357, 2321-2324.
-
(2007)
New England Journal of Medicine
, vol.357
, pp. 2321-2324
-
-
Sharfstein, J.M.1
North, M.2
Serwint, J.R.3
-
92
-
-
3042738919
-
Acetaminophen and the U.S. Acute Liver Failure Study Group: Lowering the risks of hepatic failure
-
Lee, W. M. (2004). Acetaminophen and the U.S. Acute Liver Failure Study Group: Lowering the risks of hepatic failure. Hepatology 40, 6-9.
-
(2004)
Hepatology
, vol.40
, pp. 6-9
-
-
Lee, W.M.1
-
93
-
-
84889777514
-
Take two possibly lethal pills and call me in the morning
-
Fortune, February 20
-
Stipp, D. (2006). Take two possibly lethal pills and call me in the morning. Fortune, February 20.
-
(2006)
-
-
Stipp, D.1
-
94
-
-
0031777185
-
Cyclooxygenases 1 and 2
-
Three excellent reviews on this topic are
-
Three excellent reviews on this topic are: (a) Vane, J. R., Bakhle, Y. S., and Botting, R. M. (1998). Cyclooxygenases 1 and 2. Annual Reviews of Pharmacology & Toxicology 38, 97-120.
-
(1998)
Annual Reviews of Pharmacology & Toxicology
, vol.38
, pp. 97-120
-
-
Vane, J.R.1
Bakhle, Y.S.2
Botting, R.M.3
-
95
-
-
28244491250
-
The development of drugs that target cyclooxygenase-2
-
edited by R. E. Harris, Humana Press, Totowa, NJ, Chapter 16
-
Maziasz, T., Khan, K. N., Talley, J., Gierse, J., and Seibert, K. (2003). The development of drugs that target cyclooxygenase-2, in COX-2 Blockade in Cancer Prevention and Therapy, edited by R. E. Harris, Humana Press, Totowa, NJ, Chapter 16, pp. 259-277.
-
(2003)
COX-2 Blockade in Cancer Prevention and Therapy
, pp. 259-277
-
-
Maziasz, T.1
Khan, K.N.2
Talley, J.3
Gierse, J.4
Seibert, K.5
-
96
-
-
0037108979
-
COX-3: A cyclooxygenase variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure and expression
-
Chandrasekharan, N. V., Dai, H., Roos, L. T., Evanson, N. K., Tomsik, J., Elton, T. S., and Simmons, D. L. (2002). COX-3: A cyclooxygenase variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure and expression. Proceedings of the National Academy of Sciences 99 (21), 13926-13931.
-
(2002)
Proceedings of the National Academy of Sciences
, vol.99
, Issue.21
, pp. 13926-13931
-
-
Chandrasekharan, N.V.1
Dai, H.2
Roos, L.T.3
Evanson, N.K.4
Tomsik, J.5
Elton, T.S.6
Simmons, D.L.7
-
97
-
-
0025160887
-
Antiinflammatory and safety profile of DuP-697, a novel orally effective prostaglandin synthesis inhibitor
-
Gans, K. R., Galbraith, W., Roman, R. J., Haber, S. B., Kerr, J. S., Schmidt, W. K., Smith, C., Hewes, W. E., and Ackerman, N. R. (1990). Antiinflammatory and safety profile of DuP-697, a novel orally effective prostaglandin synthesis inhibitor. Journal of Pharmacology and Experimental Therapeutics 254, 180-187.
-
(1990)
Journal of Pharmacology and Experimental Therapeutics
, vol.254
, pp. 180-187
-
-
Gans, K.R.1
Galbraith, W.2
Roman, R.J.3
Haber, S.B.4
Kerr, J.S.5
Schmidt, W.K.6
Smith, C.7
Hewes, W.E.8
Ackerman, N.R.9
-
98
-
-
0033601089
-
Antiinflammatory and upper gastrointestinal effects of Celecoxib in rheumatoid arthritis. A randomized controlled trial
-
Simon, L. S., Weaver, A. L., Graham, D. Y., Kivitz, A. J., Lipsky, P. E., Hubbard, R. C., Isakson, P. C., Verburg, K. M., Yu, S. S., Zhao, W. W., and Geis, G. S. (1999). Antiinflammatory and upper gastrointestinal effects of Celecoxib in rheumatoid arthritis. A randomized controlled trial. Journal of the American Medical Association 282, 1921-1928.
-
(1999)
Journal of the American Medical Association
, vol.282
, pp. 1921-1928
-
-
Simon, L.S.1
Weaver, A.L.2
Graham, D.Y.3
Kivitz, A.J.4
Lipsky, P.E.5
Hubbard, R.C.6
Isakson, P.C.7
Verburg, K.M.8
Yu, S.S.9
Zhao, W.W.10
Geis, G.S.11
-
99
-
-
19744380776
-
Cardiovascular events associated with Rofecoxib in a colorectal adenoma chemoprevention trial
-
for the APPROVe Trail Investigators
-
Bresalier, R. S., Sandler, R. S., Quan, H., Bolognese, J. A., Oxnius, B., Horgan, K., Lines, C., Riddell, R., Morton, D., Lanas, A., Konstam, M. A., and Baron, J. A., for the APPROVe Trail Investigators (2005). Cardiovascular events associated with Rofecoxib in a colorectal adenoma chemoprevention trial. New England Journal of Medicine 352, 1092-1102.
-
(2005)
New England Journal of Medicine
, vol.352
, pp. 1092-1102
-
-
Bresalier, R.S.1
Sandler, R.S.2
Quan, H.3
Bolognese, J.A.4
Oxnius, B.5
Horgan, K.6
Lines, C.7
Riddell, R.8
Morton, D.9
Lanas, A.10
Konstam, M.A.11
Baron, J.A.12
-
100
-
-
20144365496
-
Cardiovascular risk associated with Celecoxib in a clinical trial for colorectal adenoma prevention
-
for the APC Study Investigators
-
Solomon, S. D., McMurray J. J. V., Pfeffer, M. A., Wittes, J., Fowler, R., Finn, P., Anderson, W. F., Zauber, A., Hawk, E., Bertagnolli, M., for the APC Study Investigators (2005). Cardiovascular risk associated with Celecoxib in a clinical trial for colorectal adenoma prevention. New England Journal of Medicine 352, 1071-1080.
-
(2005)
New England Journal of Medicine
, vol.352
, pp. 1071-1080
-
-
Solomon, S.D.1
McMurray, J.J.V.2
Pfeffer, M.A.3
Wittes, J.4
Fowler, R.5
Finn, P.6
Anderson, W.F.7
Zauber, A.8
Hawk, E.9
Bertagnolli, M.10
-
101
-
-
33847373072
-
Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Antiinflammatory Prevention Trial (ADAPT)
-
ADAPT Research Group
-
ADAPT Research Group (2006). Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Antiinflammatory Prevention Trial (ADAPT). Public Library of Science Clinical Trials1:e33 (http://dx.doi.org/10.1371/journal.pctr.0010033).
-
(2006)
Public Library of Science Clinical Trials1
-
-
-
102
-
-
22444441665
-
Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors on conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis
-
For two examples of such studies see
-
For two examples of such studies see: (a) Hippisley-Cox, J., Coupland, C. (2005). Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors on conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. British Medical Journal 330, 1366-1372.
-
(2005)
British Medical Journal
, vol.330
, pp. 1366-1372
-
-
Hippisley-Cox, J.1
Coupland, C.2
-
103
-
-
33749339372
-
Cardiovascular risk and inhibition of cyclooxygenas. A systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2
-
McGettigan, P., and Henry, D. (2006). Cardiovascular risk and inhibition of cyclooxygenas. A systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. Journal of the American Medical Association 296, 1633-1644.
-
(2006)
Journal of the American Medical Association
, vol.296
, pp. 1633-1644
-
-
McGettigan, P.1
Henry, D.2
-
104
-
-
84889860867
-
-
Identifier: NCT00346216
-
www.clinicaltrials.gov Identifier: NCT00346216.
-
-
-
-
105
-
-
20544432452
-
Tailoring arthritis therapy in the wake of the NSAID crisis
-
Olsen, N. J. (2005). Tailoring arthritis therapy in the wake of the NSAID crisis. New England Journal of Medicine 353, 2578-2580.
-
(2005)
New England Journal of Medicine
, vol.353
, pp. 2578-2580
-
-
Olsen, N.J.1
-
106
-
-
84889842536
-
As ads surge, more get Rx's filled
-
USA Today, March 4
-
Appleby, J. (2008). As ads surge, more get Rx's filled. USA Today, March 4.
-
(2008)
-
-
Appleby, J.1
-
107
-
-
84889783011
-
Research and Development in the Pharmaceutical
-
Congressional Budget Office, Industry Publication, Washington, DC, October
-
Congressional Budget Office (2006). Research and Development in the Pharmaceutical Industry Publication No. 2589, Washington, DC, October.
-
(2006)
, pp. 2589
-
-
-
108
-
-
84889819306
-
-
Data based on the Pharmaceutical Research and Manufacturers of America Annual Survey of 2006
-
Data based on the Pharmaceutical Research and Manufacturers of America Annual Survey of 2006.
-
-
-
-
109
-
-
84889789874
-
An Update on the FY 2008 R & D Budget AAAS R & D Budget and Policy Program
-
Koizumi, K. (2007). An Update on the FY 2008 R & D Budget AAAS R & D Budget and Policy Program, http://www.aaas.org/spp/rd.
-
(2007)
-
-
Koizumi, K.1
-
110
-
-
84889787533
-
Pharmaceutical Industry Profile 2008
-
Pharmaceutical Research and Manufacturers of America, Washington, DC
-
Pharmaceutical Research and Manufacturers of America (2008). Pharmaceutical Industry Profile 2008, PhRMA, Washington, DC.
-
(2008)
PhRMA
-
-
-
111
-
-
38949213691
-
The cost of pushing pills: A new estimate of pharmaceutical promotion expenditures in the United States
-
Gagnon, M. A., and Lexchin, J. (2008). The cost of pushing pills: A new estimate of pharmaceutical promotion expenditures in the United States. Public Library of Science Medicine 5 (1), e1dol:10.1371/journal.pmed.0050001.
-
(2008)
Public Library of Science Medicine
, vol.5
, Issue.1
-
-
Gagnon, M.A.1
Lexchin, J.2
-
112
-
-
34547950500
-
A decade of direct-to-consumer advertising of prescription drugs
-
Donohue, J. M., Cevasco, M., and Rosenthal, M. B. (2007). A decade of direct-to-consumer advertising of prescription drugs. New England Journal of Medicine 257, 673-681.
-
(2007)
New England Journal of Medicine
, vol.257
, pp. 673-681
-
-
Donohue, J.M.1
Cevasco, M.2
Rosenthal, M.B.3
-
113
-
-
84889828365
-
Men's Health, and Women's Health with assistance from the FDA's Division-Drug Marketing
-
10th Annual Survey on Consumer Reaction to DTC Advertising of Prescription Medicines, conducted by Prevention, May 23, New York
-
10th Annual Survey on Consumer Reaction to DTC Advertising of Prescription Medicines, conducted by Prevention, Men's Health, and Women's Health with assistance from the FDA's Division-Drug Marketing, Advertising and Communication, May 23, 2007, New York.
-
(2007)
Advertising and Communication
-
-
-
114
-
-
0038482206
-
The quality of healthcare delivered to adults in the United States
-
McGlynn, E. A., Asch, M., Adams, J., Keesey, J., Hicks, J., DeCristofaro, A., and Kerr, E. A. (2003). The quality of healthcare delivered to adults in the United States. New England Journal of Medicine 348, 2635-2645.
-
(2003)
New England Journal of Medicine
, vol.348
, pp. 2635-2645
-
-
McGlynn, E.A.1
Asch, M.2
Adams, J.3
Keesey, J.4
Hicks, J.5
DeCristofaro, A.6
Kerr, E.A.7
-
115
-
-
27244459496
-
Patient and physician attitudes and behaviors associated with DTC promotion of prescription drugs-Summary of FDA Survey Research Results Final Report
-
US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, November 19, 2004, Washington, DC
-
Aikin, K., Swasy, J. L., and Braman, A. C. (2004). Patient and physician attitudes and behaviors associated with DTC promotion of prescription drugs-Summary of FDA Survey Research Results Final Report. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, November 19, 2004, Washington, DC.
-
(2004)
-
-
Aikin, K.1
Swasy, J.L.2
Braman, A.C.3
-
116
-
-
84889852807
-
PhRMA Guiding Principles
-
Pharmaceutical Research and Manufacturers of America, PhRMA, Washington, DC
-
Pharmaceutical Research and Manufacturers of America (2005). PhRMA Guiding Principles. Direct to Consumer Advertisement About Prescription Medicines, PhRMA, Washington, DC.
-
(2005)
Direct to Consumer Advertisement About Prescription Medicines
-
-
-
118
-
-
0030926566
-
The international index of erectile dysfunction (IIEF): A multidimensional scale for the assessment of erectile dysfunction
-
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., and Mishra, A. (1997). The international index of erectile dysfunction (IIEF): A multidimensional scale for the assessment of erectile dysfunction. Urology 49, 822-830.
-
(1997)
Urology
, vol.49
, pp. 822-830
-
-
Rosen, R.C.1
Riley, A.2
Wagner, G.3
Osterloh, I.H.4
Kirkpatrick, J.5
Mishra, A.6
-
119
-
-
26444534291
-
Sildenafil citrate therapy for pulmonary arterial hypertension
-
for the Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group
-
Galie, N., Ghofrani, H. A. Torbicki, A., Barst, R. J., Rubin, L. J., Badesch, D., Fleming, T., Parpia, T., Burgess, G., Branzi, A., Grimminger, F., Kurzyna, M., and Simonneau, G., for the Sildenafil Use in Pulmonary Arterial Hypertension (SUPER) Study Group (2005). Sildenafil citrate therapy for pulmonary arterial hypertension. New England Journal of Medicine 353, 2148-2157.
-
(2005)
New England Journal of Medicine
, vol.353
, pp. 2148-2157
-
-
Galie, N.1
Ghofrani, H.A.2
Torbicki, A.3
Barst, R.J.4
Rubin, L.J.5
Badesch, D.6
Fleming, T.7
Parpia, T.8
Burgess, G.9
Branzi, A.10
Grimminger, F.11
Kurzyna, M.12
Simonneau, G.13
-
120
-
-
33845959105
-
Scrooge and intellectual property rights
-
Stiglitz, J. E. (2006). Scrooge and intellectual property rights. British Medical Journal 333, 1279-1280.
-
(2006)
British Medical Journal
, vol.333
, pp. 1279-1280
-
-
Stiglitz, J.E.1
-
123
-
-
35448974479
-
Ending extreme poverty, improving the human condition
-
Friedrich, M. J., (2007). Ending extreme poverty, improving the human condition. Journal of the American Medical Association 298, 1849-1851.
-
(2007)
Journal of the American Medical Association
, vol.298
, pp. 1849-1851
-
-
Friedrich, M.J.1
-
124
-
-
35448994357
-
Informing resource-poor populations and the delivery of entitled health and social services in rural India. A cluster randomized controlled trial
-
Pandey, P., Sehgal, A. R., Riboud, M., Levine, D., and Goyal, M. (2007). Informing resource-poor populations and the delivery of entitled health and social services in rural India. A cluster randomized controlled trial. Journal of the American Medical Association 298, 1867-1875.
-
(2007)
Journal of the American Medical Association
, vol.298
, pp. 1867-1875
-
-
Pandey, P.1
Sehgal, A.R.2
Riboud, M.3
Levine, D.4
Goyal, M.5
-
125
-
-
35448942712
-
Improving child survival through environmental and nutritional interventions. The importance of targeting interventions toward the poor
-
Gakidou, E., Oza, S., Fuertes, C. V., Li, A. Y., Lee, D. K., Sousa, A., Hogan, M. C., Vander Horn, S., and Ezzati, M. (2007). Improving child survival through environmental and nutritional interventions. The importance of targeting interventions toward the poor. Journal of the American Medical Association 298, 1876-1887.
-
(2007)
Journal of the American Medical Association
, vol.298
, pp. 1876-1887
-
-
Gakidou, E.1
Oza, S.2
Fuertes, C.V.3
Li, A.Y.4
Lee, D.K.5
Sousa, A.6
Hogan, M.C.7
Vander Horn, S.8
Ezzati, M.9
-
126
-
-
84889815322
-
-
www.gsk.com/malaria.
-
-
-
-
127
-
-
84889768369
-
-
www.novartisfoundation.org.
-
-
-
-
128
-
-
84889772499
-
-
www.astrazeneca.com.
-
-
-
-
129
-
-
84889877473
-
-
www.sustainability2006.bayer.com.
-
-
-
-
130
-
-
84889805322
-
-
www.merck.com/cr/enabling_access/developing_world.
-
-
-
-
131
-
-
84889814606
-
-
www.diflucanpartnership.org.
-
-
-
-
132
-
-
33646196269
-
Global Burden of Disease and Risk Factors
-
Chapter 3, Table 3.6, Harvard University Press, Cambridge, MA
-
Lopez, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T., and Murray, C. J. L., editors (2006). Global Burden of Disease and Risk Factors, Chapter 3, Table 3.6, Harvard University Press, Cambridge, MA. www.dcp2.org/pubs/gbd/3/table/3.6.
-
(2006)
-
-
Lopez, A.D.1
Mathers, C.D.2
Ezzati, M.3
Jamison, D.T.4
Murray, C.J.L.5
-
133
-
-
84889797816
-
-
www.mectizan.com.
-
-
-
-
134
-
-
0023711888
-
Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-Aza-homoerythromycin A derivatives; A new class of macrolide antibiotics: The azalides
-
Bright, G. M., Nagel, A. A., Bordner, J., Desai, K. A., DiBrino, J. N., Nowakowska, J., Vincent, L., Watrous, R. M., Sciavolino, F. C., English, A. R., Retsema, J. A., Anderson, M. R., Brennan, L. A., Borovoy, R. J., Cimochowski, C. R., Faiella, J. A., Girard, A. E., Girard, D., Harbert, C., Manousos, M., and Mason, R. (1988). Synthesis, in vitro and in vivo activity of novel 9-deoxo-9a-Aza-homoerythromycin A derivatives; A new class of macrolide antibiotics: The azalides. Journal of Antibiotics 41, 1029-1047.
-
(1988)
Journal of Antibiotics
, vol.41
, pp. 1029-1047
-
-
Bright, G.M.1
Nagel, A.A.2
Bordner, J.3
Desai, K.A.4
DiBrino, J.N.5
Nowakowska, J.6
Vincent, L.7
Watrous, R.M.8
Sciavolino, F.C.9
English, A.R.10
Retsema, J.A.11
Anderson, M.R.12
Brennan, L.A.13
Borovoy, R.J.14
Cimochowski, C.R.15
Faiella, J.A.16
Girard, A.E.17
Girard, D.18
Harbert, C.19
Manousos, M.20
Mason, R.21
more..
-
135
-
-
0023493448
-
Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution
-
Girard, A. E., Girard, D., English, A. R., Gootz, T. D., Cimochowski, C. R., Faiella, J. A., Haskell, S. L., and Retsema, J. A. (1987). Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Antimicrobial Agents and Chemotherapy 31, 1948-1954.
-
(1987)
Antimicrobial Agents and Chemotherapy
, vol.31
, pp. 1948-1954
-
-
Girard, A.E.1
Girard, D.2
English, A.R.3
Gootz, T.D.4
Cimochowski, C.R.5
Faiella, J.A.6
Haskell, S.L.7
Retsema, J.A.8
-
136
-
-
0024522884
-
In Vitro and In Vivo uptake of Azithromycin (CP-62,993) by phagocytic cells: Possible mechanism of delivery and release at sites of infection
-
Gladue, R. P., Bright, G. M., Isaacson, R. E., and Newborg, M. F. (1989). In Vitro and In Vivo uptake of Azithromycin (CP-62,993) by phagocytic cells: Possible mechanism of delivery and release at sites of infection. Antimicrobial Agents and Chemotherapy 33, 277-282.
-
(1989)
Antimicrobial Agents and Chemotherapy
, vol.33
, pp. 277-282
-
-
Gladue, R.P.1
Bright, G.M.2
Isaacson, R.E.3
Newborg, M.F.4
-
137
-
-
84889860727
-
-
Pliva sells the drug under a different trademark, Sunamed, in Central and Eastern Europe
-
Pliva sells the drug under a different trademark, Sunamed, in Central and Eastern Europe.
-
-
-
-
138
-
-
42549117309
-
Eliminating blinding trachoma
-
Cook, J. A. (2008). Eliminating blinding trachoma. New England Journal of Medicine 353, 1777-1779.
-
(2008)
New England Journal of Medicine
, vol.353
, pp. 1777-1779
-
-
Cook, J.A.1
-
139
-
-
42549125236
-
Two doses of azithromycin to eliminate trachoma in a Tanzanian community
-
Solomon, A. W., Harding-Esch, E., Alexander, N. D. E., Aguirre, A., HollAnd, M. J., Bailey, R. K., Foster, A., Mabey, D. C. W., Massae, P. A., Courtright, P., and Shao, J. F. (2008). Two doses of azithromycin to eliminate trachoma in a Tanzanian community. New England Journal of Medicine 358, 1870-1871.
-
(2008)
New England Journal of Medicine
, vol.358
, pp. 1870-1871
-
-
Solomon, A.W.1
Harding-Esch, E.2
Alexander, N.D.E.3
Aguirre, A.4
HollAnd, M.J.5
Bailey, R.K.6
Foster, A.7
Mabey, D.C.W.8
Massae, P.A.9
Courtright, P.10
Shao, J.F.11
-
140
-
-
84889868724
-
A Phase 2/3, Randomized, Double Blind, Comparative Trial of Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Africa
-
Presented at 5th European Congress of Tropical Medicine & International Health, Amsterdam, The Netherlands, May 24-28, 2007
-
Lewis, D., Mulenga, M., Mugyenyi, P., Sagara, I., Wasunna, M., Oduro, A., Sie, A., Tiono, A., Sarkar, S., Kityo, C., Djimde, A., Nambozi, M., Juma, R., Germain, M., Ansah, P., Ouedraogo, A., Aman, R., Kokwaro, G., and Dunne, M. (2007). A Phase 2/3, Randomized, Double Blind, Comparative Trial of Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Africa. Presented at 5th European Congress of Tropical Medicine & International Health, Amsterdam, The Netherlands, May 24-28, 2007.
-
(2007)
-
-
Lewis, D.1
Mulenga, M.2
Mugyenyi, P.3
Sagara, I.4
Wasunna, M.5
Oduro, A.6
Sie, A.7
Tiono, A.8
Sarkar, S.9
Kityo, C.10
Djimde, A.11
Nambozi, M.12
Juma, R.13
Germain, M.14
Ansah, P.15
Ouedraogo, A.16
Aman, R.17
Kokwaro, G.18
Dunne, M.19
-
141
-
-
84873148772
-
A Phase 3, Randomized, Open-Label, Comparative Trial of Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of uncomplicated Plasmodium falciparum Malaria in Africa
-
Philadelphia, November 4-8, 2007
-
Chandra, R., Lewis, D., Oduro, A., Mulenga, M., Sagara, I., Sie, A., Tiono, A., Dieng, Y., Oguto, B., Sarkar, S., Ansah, P., Nambosi, M., Djimde, A., Zoungrana, A., Ouedraogo, A., Fall, M., Tina Otieno, L., and Dunne, M. (2007). A Phase 3, Randomized, Open-Label, Comparative Trial of Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of uncomplicated Plasmodium falciparum Malaria in Africa. Presented at 56th Annual Meeting of American Society of Tropical Medicine and Hygiene, Philadelphia, November 4-8, 2007.
-
(2007)
Presented at 56th Annual Meeting of American Society of Tropical Medicine and Hygiene
-
-
Chandra, R.1
Lewis, D.2
Oduro, A.3
Mulenga, M.4
Sagara, I.5
Sie, A.6
Tiono, A.7
Dieng, Y.8
Oguto, B.9
Sarkar, S.10
Ansah, P.11
Nambosi, M.12
Djimde, A.13
Zoungrana, A.14
Ouedraogo, A.15
Fall, M.16
Tina Otieno, L.17
Dunne, M.18
-
142
-
-
84889857467
-
-
www.ifpma.org/healthpartnerships.
-
-
-
-
143
-
-
84889775930
-
Where have all the new drugs gone: Industry's medicine cabinet is running empty on compounds
-
The Newark Star Ledger, January 9
-
Jordan, G. E. (2008). Where have all the new drugs gone: Industry's medicine cabinet is running empty on compounds. The Newark Star Ledger, January 9.
-
(2008)
-
-
Jordan, G.E.1
-
144
-
-
0030947897
-
The new drug approvals of 1993, 1994 and 1995: Trends in drug development
-
Kaitlin, K. I., and Manocchia, M. (1997). The new drug approvals of 1993, 1994 and 1995: Trends in drug development. American Journal of Therapeutics 4, 46-54.
-
(1997)
American Journal of Therapeutics
, vol.4
, pp. 46-54
-
-
Kaitlin, K.I.1
Manocchia, M.2
-
145
-
-
84889773671
-
Federal Register
-
October 12
-
Federal Register (2007). 72, 58103-58106, October 12.
-
(2007)
, vol.72
, pp. 58103-58106
-
-
-
146
-
-
23044491985
-
Is declining innovation in the pharmaceutical industry a myth?
-
Schmid, E. F., and Smith, D. A. (2005). Is declining innovation in the pharmaceutical industry a myth? Drug Discovery Today 10, 1031-1039.
-
(2005)
Drug Discovery Today
, vol.10
, pp. 1031-1039
-
-
Schmid, E.F.1
Smith, D.A.2
-
147
-
-
84887199656
-
Celgene: The pharmaceutical Phoenix
-
Barer, S. (2007). Celgene: The pharmaceutical Phoenix. Chemical Heritage Newsmagazine 24, 1-2.
-
(2007)
Chemical Heritage Newsmagazine
, vol.24
, pp. 1-2
-
-
Barer, S.1
-
148
-
-
84889873804
-
FDA official sees some delays over safety
-
Reuters, May 27
-
Richwine, L., and Heavey, S. (2008). FDA official sees some delays over safety. Reuters, May 27.
-
(2008)
-
-
Richwine, L.1
Heavey, S.2
-
149
-
-
84889834243
-
New drugs entering clinical testing in top 10 firms jumped 52% in 2003-2005
-
Tufts Center for the Study of Drug Development
-
Tufts Center for the Study of Drug Development (2006). New drugs entering clinical testing in top 10 firms jumped 52% in 2003-2005. Tufts CSDD Impact Report 8 (3), 1-2.
-
(2006)
Tufts CSDD Impact Report
, vol.8
, Issue.3
, pp. 1-2
-
-
-
150
-
-
84889768543
-
-
www.merck.com/finance/pipeline.swf and www.pfizer.com/files/research/pipeline/2008_0228/ pipeline_208_0228.pdf.
-
-
-
-
151
-
-
31044436096
-
The view from the top
-
Haran, C., and DeVita, V. (2005). The view from the top. Cancer World, Issue 6, 38-43.
-
(2005)
Cancer World
, Issue.6
, pp. 38-43
-
-
Haran, C.1
DeVita, V.2
-
152
-
-
85013312416
-
Tumor Angiogenesis: Therapeutic implications
-
Folkman, J. (1971). Tumor Angiogenesis: Therapeutic implications. New England Journal of Medicine 285, 1182-1186.
-
(1971)
New England Journal of Medicine
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
153
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGR antibody for treating cancer
-
Ferrara, N., Hillan, K. J., Gerber, H.-P., and Novotny, W. (2004). Discovery and development of bevacizumab, an anti-VEGR antibody for treating cancer. Nature Reviews Drug Discovery 3, 391-400.
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.-P.3
Novotny, W.4
-
154
-
-
84889849104
-
-
SUGEN was a biotech company first acquired by Pharmacia, which later merged with Pfizer Inc
-
SUGEN was a biotech company first acquired by Pharmacia, which later merged with Pfizer Inc.
-
-
-
-
155
-
-
34548316976
-
Molecular basis for sunitinib efficacy and future clinical development
-
Faivre, S., Demetri, G., Sargenti, W., and Raymond, E. (2007). Molecular basis for sunitinib efficacy and future clinical development. Nature Reviews Drug Discovery 6, 734-745.
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, pp. 734-745
-
-
Faivre, S.1
Demetri, G.2
Sargenti, W.3
Raymond, E.4
-
156
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer, R. J., Hutson, T. E., Tomczak, P., Michaelson, M. D., Bukowski, R. M., Rixe, O., Oudard, S., Negrier, S., Szczylik, C., Kim, S. T., Chen, I., Bycott, P. W., Baum, C. M., and Figlin, R. A. (2007). Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. New England Journal of Medicine 356, 115-124.
-
(2007)
New England Journal of Medicine
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
157
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: A randomised controlled trial
-
Demetri, G. D., van Oosteroh, A. T., Garrett, C. R., Blackstein, M. E., Shah, M. H., Verweij, J., McArthur, G., Judson, I. R., Heinrich, M. C., Morgan, J. A., Desai, J., Fletcher, C. D., George, S., Bello, C. L., Huang, X., Baum, C. M., and Cesali, P. G. (2006). Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: A randomised controlled trial. Lancet 368, 1329-1338.
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
Van Oosteroh, A.T.2
Garrett, C.R.3
Blackstein, M.E.4
Shah, M.H.5
Verweij, J.6
McArthur, G.7
Judson, I.R.8
Heinrich, M.C.9
Morgan, J.A.10
Desai, J.11
Fletcher, C.D.12
George, S.13
Bello, C.L.14
Huang, X.15
Baum, C.M.16
Cesali, P.G.17
-
158
-
-
45349092818
-
Can cancer cure Pfizer?
-
June
-
Herper, M. (2008). Can cancer cure Pfizer? Forbes, June 2.
-
(2008)
Forbes
, pp. 2
-
-
Herper, M.1
-
159
-
-
84889838752
-
Dr. Optimistic. A Pfizer scientist sees research dividends ahead
-
New York Times, July
-
Berenson, A. (2006). Dr. Optimistic. A Pfizer scientist sees research dividends ahead. New York Times, July 18.
-
(2006)
, pp. 18
-
-
Berenson, A.1
|