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Volumn 25, Issue 4, 2004, Pages 186-192

Principles: Receptor theory in pharmacology

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN RECEPTOR; ALCURONIUM; ALPHA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BRADYKININ RECEPTOR; CALCITONIN; CANNABINOID 1 RECEPTOR; CHEMOKINE; DRUG RECEPTOR; GHRELIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; LIGAND; METHADONE; MUSCARINIC RECEPTOR; OPIATE PEPTIDE; OPIATE RECEPTOR; PHEROMONE RECEPTOR; PHOSPHOLIPASE C; RECEPTOR; RECEPTOR ACTIVITY MODIFYING PROTEIN; RIMONABANT;

EID: 1942517868     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2004.02.012     Document Type: Review
Times cited : (355)

References (60)
  • 3
    • 0036688216 scopus 로고    scopus 로고
    • The emergence of drug receptor theory
    • Maehle A.-H., et al. The emergence of drug receptor theory. Nat. Rev. Drug Discov. 1:2002;637-641.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 637-641
    • Maehle, A.-H.1
  • 5
    • 77049220618 scopus 로고
    • Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory
    • Ariens E.J. Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory. Arch. Int. Pharmacodyn. Ther. 99:1954;32-49.
    • (1954) Arch. Int. Pharmacodyn. Ther. , vol.99 , pp. 32-49
    • Ariens, E.J.1
  • 6
    • 0010673662 scopus 로고
    • A modification of receptor theory
    • Stephenson R.P. A modification of receptor theory. Br. J. Pharmacol. 11:1956;379-393.
    • (1956) Br. J. Pharmacol. , vol.11 , pp. 379-393
    • Stephenson, R.P.1
  • 8
    • 0002060353 scopus 로고
    • The relationship between classical and cooperative models for drug action
    • H.P. Rang. University Park Press
    • Colquhoun D. The relationship between classical and cooperative models for drug action. Rang H.P. Drug Receptors. 1973;149-182 University Park Press.
    • (1973) Drug Receptors , pp. 149-182
    • Colquhoun, D.1
  • 9
    • 0023958554 scopus 로고
    • Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods
    • Ehlert F.J. Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. Mol. Pharmacol. 33:1988;187-194.
    • (1988) Mol. Pharmacol. , vol.33 , pp. 187-194
    • Ehlert, F.J.1
  • 10
    • 0002355204 scopus 로고
    • The use of β-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes
    • N.J. Harper, Simmonds A.B. Academic Press
    • Furchgott R.F. The use of β-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes. Harper N.J., Simmonds A.B. Advances in Drug Research. Vol. 3:1966;21-55 Academic Press.
    • (1966) Advances in Drug Research , vol.3 , pp. 21-55
    • Furchgott, R.F.1
  • 11
    • 0000328674 scopus 로고
    • The classification of adrenoreceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory
    • H. Blaschko, & E. Muscholl. Springer-Verlag
    • Furchgott R.F. The classification of adrenoreceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. Blaschko H., Muscholl E. Handbook of Experimental Pharmacology: Catecholamines. Vol. 33:1972;283-335 Springer-Verlag.
    • (1972) Handbook of Experimental Pharmacology: Catecholamines , vol.33 , pp. 283-335
    • Furchgott, R.F.1
  • 12
    • 0002177268 scopus 로고
    • The quantitative effects of antagonistic drugs
    • Gaddum, J.H. (1937) The quantitative effects of antagonistic drugs. J. Physiol. 89, 7P-9P.
    • (1937) J. Physiol. , vol.89
    • Gaddum, J.H.1
  • 13
    • 0001806350 scopus 로고
    • A critical survey of receptor theories of drug action
    • J.M. Van Rossum. Springer-Verlag
    • MacKay D. A critical survey of receptor theories of drug action. Van Rossum J.M. Kinetics of Drug Action. 1977;255-322 Springer-Verlag.
    • (1977) Kinetics of Drug Action , pp. 255-322
    • MacKay, D.1
  • 14
    • 0002859426 scopus 로고
    • A theory of drug action based on the rate of drug-receptor combination
    • Paton W.D.M. A theory of drug action based on the rate of drug-receptor combination. Proc. R. Soc. London B Biol. Sci. 154:1961;21-69.
    • (1961) Proc. R. Soc. London B Biol. Sci. , vol.154 , pp. 21-69
    • Paton, W.D.M.1
  • 15
    • 78651175536 scopus 로고
    • The uptake of atropine and related drugs by intestinal smooth muscle of the guinea-pig in relation to acetylcholine receptors
    • Paton W.D.M., Rang H.P. The uptake of atropine and related drugs by intestinal smooth muscle of the guinea-pig in relation to acetylcholine receptors. Proc. R. Soc. Lond. B. Biol. Sci. 163:1965;1-44.
    • (1965) Proc. R. Soc. Lond. B. Biol. Sci. , vol.163 , pp. 1-44
    • Paton, W.D.M.1    Rang, H.P.2
  • 16
    • 28244497552 scopus 로고
    • Drug antagonism and pAx
    • Schild H.O. Drug antagonism and pAx. Pharmacol. Rev. 9:1957;242-246.
    • (1957) Pharmacol. Rev. , vol.9 , pp. 242-246
    • Schild, H.O.1
  • 17
    • 0009644628 scopus 로고
    • Some quantitative uses of drug antagonists
    • Arunlakshana O., Schild H.O. Some quantitative uses of drug antagonists. Br. J. Pharmacol. 14:1959;48-58.
    • (1959) Br. J. Pharmacol. , vol.14 , pp. 48-58
    • Arunlakshana, O.1    Schild, H.O.2
  • 18
    • 0001344479 scopus 로고
    • Limitations of molecular pharmacology. Some implications of the basic assumptions underlying calculations on drug-receptor interactions and the significance of biological drug parameters
    • Van Rossum J.M. Limitations of molecular pharmacology. Some implications of the basic assumptions underlying calculations on drug-receptor interactions and the significance of biological drug parameters. Adv. Drug Res. 3:1966;189-223.
    • (1966) Adv. Drug Res. , vol.3 , pp. 189-223
    • Van Rossum, J.M.1
  • 19
    • 0014299372 scopus 로고
    • Pharmacological receptors
    • Waud D.R. Pharmacological receptors. Pharmacol. Rev. 20:1968;49-88.
    • (1968) Pharmacol. Rev. , vol.20 , pp. 49-88
    • Waud, D.R.1
  • 21
    • 0037794320 scopus 로고    scopus 로고
    • Predicting therapeutic value in the lead optimization phase of drug discovery
    • Kenakin T.P. Predicting therapeutic value in the lead optimization phase of drug discovery. Nat. Rev. Drug Discov. 2:2003;429-438.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 429-438
    • Kenakin, T.P.1
  • 22
    • 84965075853 scopus 로고
    • A study of the 'desensitization' produced by acetylcholine at the motor end-plate
    • Katz B., Thesleff S. A study of the 'desensitization' produced by acetylcholine at the motor end-plate. J. Physiol. 138:1957;63-80.
    • (1957) J. Physiol. , vol.138 , pp. 63-80
    • Katz, B.1    Thesleff, S.2
  • 23
    • 70449143838 scopus 로고
    • Interaction at end-plate receptors between different choline derivatives
    • Del Castillo J., Katz B. Interaction at end-plate receptors between different choline derivatives. Proc. R. Soc. Lond. B. Biol. Sci. 146:1957;369-381.
    • (1957) Proc. R. Soc. Lond. B. Biol. Sci. , vol.146 , pp. 369-381
    • Del Castillo, J.1    Katz, B.2
  • 24
    • 78651189765 scopus 로고
    • On the nature of allosteric transitions: A plausible model
    • Monod J., et al. On the nature of allosteric transitions: a plausible model. J. Biol. Chem. 12:1965;88-118.
    • (1965) J. Biol. Chem. , vol.12 , pp. 88-118
    • Monod, J.1
  • 25
    • 0014115893 scopus 로고
    • On the application of a "plausible model" of allosteric proteins to the receptor for acetylcholine
    • Karlin A. On the application of a "plausible model" of allosteric proteins to the receptor for acetylcholine. J. Theor. Biol. 16:1967;306-320.
    • (1967) J. Theor. Biol. , vol.16 , pp. 306-320
    • Karlin, A.1
  • 26
    • 0015535998 scopus 로고
    • On the analysis of pharmacological experiments in terms of an allosteric receptor model
    • Thron C.D. On the analysis of pharmacological experiments in terms of an allosteric receptor model. Mol. Pharmacol. 9:1973;1-9.
    • (1973) Mol. Pharmacol. , vol.9 , pp. 1-9
    • Thron, C.D.1
  • 27
    • 0019137579 scopus 로고
    • A ternary complex model explains the agonist-specific binding properties of adenylate cyclase coupled β-adrenergic receptor
    • DeLean A., et al. A ternary complex model explains the agonist-specific binding properties of adenylate cyclase coupled β-adrenergic receptor. J. Biol. Chem. 255:1980;7108-7117.
    • (1980) J. Biol. Chem. , vol.255 , pp. 7108-7117
    • Delean, A.1
  • 28
    • 0008442277 scopus 로고
    • Agonist induced increase in apparent β-adrenergic receptor size
    • Limbird L.E., Lefkowitz R.J. Agonist induced increase in apparent β-adrenergic receptor size. Proc. Natl. Acad. Sci. U. S. A. 75:1978;228-232.
    • (1978) Proc. Natl. Acad. Sci. U. S. A. , vol.75 , pp. 228-232
    • Limbird, L.E.1    Lefkowitz, R.J.2
  • 29
    • 0017394036 scopus 로고
    • Relationship between the β-adrenergic receptor and adenylate cyclase
    • Ross E.M., et al. Relationship between the β-adrenergic receptor and adenylate cyclase. J. Biol. Chem. 252:1977;5761-5775.
    • (1977) J. Biol. Chem. , vol.252 , pp. 5761-5775
    • Ross, E.M.1
  • 31
    • 0001169515 scopus 로고
    • Antagonists with negative intrinsic activity at δ-opioid receptors coupled to GTP-binding proteins
    • Costa T., Herz A. Antagonists with negative intrinsic activity at δ-opioid receptors coupled to GTP-binding proteins. Proc. Natl. Acad. Sci. U. S. A. 86:1989;7321-7325.
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 7321-7325
    • Costa, T.1    Herz, A.2
  • 32
    • 1642495639 scopus 로고    scopus 로고
    • Efficacy as a vector: The relative prevalence and paucity of inverse agonism
    • Kenakin T.P. Efficacy as a vector: the relative prevalence and paucity of inverse agonism. Mol. Pharmacol. Sci. 65:2004;2-11.
    • (2004) Mol. Pharmacol. Sci. , vol.65 , pp. 2-11
    • Kenakin, T.P.1
  • 33
    • 0027513982 scopus 로고
    • 2-adrenergic receptor: Extending the ternary complex model
    • 2-adrenergic receptor: Extending the ternary complex model. J. Biol. Chem. 268:1993;4625-4636.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4625-4636
    • Samama, P.1
  • 34
    • 0043235844 scopus 로고    scopus 로고
    • Ligand-selective receptor conformations revisited: The promise and the problem
    • Kenakin T.P. Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol. Sci. 24:2003;346-354.
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 346-354
    • Kenakin, T.P.1
  • 35
    • 0029935383 scopus 로고    scopus 로고
    • The cubic ternary complex receptor-occupancy model. I. Model description
    • Weiss J.M., et al. The cubic ternary complex receptor-occupancy model. I. Model description. J. Theor. Biol. 178:1996;151-167.
    • (1996) J. Theor. Biol. , vol.178 , pp. 151-167
    • Weiss, J.M.1
  • 36
    • 0031597627 scopus 로고    scopus 로고
    • 3H-Naloxone benzoylhydrazone binding in MOR-1-transfected Chinese hamster ovary cells: Evidence for G-protein- dependent antagonist binding
    • 3H-Naloxone benzoylhydrazone binding in MOR-1-transfected Chinese hamster ovary cells: Evidence for G-protein- dependent antagonist binding. J. Pharmacol. Exp. Ther. 286:1998;376-381.
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 376-381
    • Brown, G.P.1    Pasternak, G.W.2
  • 37
    • 0042343718 scopus 로고    scopus 로고
    • Tiotidine, a histamine H2 receptor inverse agonist binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model
    • Monczor F., et al. Tiotidine, a histamine H2 receptor inverse agonist binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. Mol. Pharmacol. 64:2003;512-520.
    • (2003) Mol. Pharmacol. , vol.64 , pp. 512-520
    • Monczor, F.1
  • 38
    • 0031941108 scopus 로고    scopus 로고
    • Mechanisms governing the activation and trafficking of the Yeast G-protein-coupled receptors
    • Stefan C.J., et al. Mechanisms governing the activation and trafficking of the Yeast G-protein-coupled receptors. Mol. Biol. Cell. 9:1998;885-899.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 885-899
    • Stefan, C.J.1
  • 39
    • 0342979873 scopus 로고    scopus 로고
    • The CB1 cannabinoid receptor can sequestor G-proteins, making them unavailable to couple to other receptors
    • Vasquez C., Lewis D.L. The CB1 cannabinoid receptor can sequestor G-proteins, making them unavailable to couple to other receptors. J. Neurosci. 19:1999;9271-9280.
    • (1999) J. Neurosci. , vol.19 , pp. 9271-9280
    • Vasquez, C.1    Lewis, D.L.2
  • 40
    • 0030826705 scopus 로고    scopus 로고
    • A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor
    • Bouaboula M., et al. A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor. J. Biol. Chem. 272:1997;22330-22339.
    • (1997) J. Biol. Chem. , vol.272 , pp. 22330-22339
    • Bouaboula, M.1
  • 41
    • 0001870572 scopus 로고    scopus 로고
    • Agonist efficacy and allosteric models of receptor action
    • Onaran H.O., Costa T. Agonist efficacy and allosteric models of receptor action. Ann. New York Acad. Sci. 812:1997;98-115.
    • (1997) Ann. New York Acad. Sci. , vol.812 , pp. 98-115
    • Onaran, H.O.1    Costa, T.2
  • 42
    • 0001158926 scopus 로고    scopus 로고
    • A look at receptor efficacy. From the signaling network of the cell to the intramolecular motion of the receptor
    • T.P. Kenakin, Angus J.A. Springer
    • Onaran H.O., et al. A look at receptor efficacy. From the signaling network of the cell to the intramolecular motion of the receptor. Kenakin T.P., Angus J.A. The Pharmacology of Functional, Biochemical, and Recombinant Systems Handbook of Experimental Pharmacology. Vol. 148:2000;217-280 Springer.
    • (2000) The Pharmacology of Functional, Biochemical, and Recombinant Systems Handbook of Experimental Pharmacology , vol.148 , pp. 217-280
    • Onaran, H.O.1
  • 43
    • 0036177114 scopus 로고    scopus 로고
    • Efficacy at G protein coupled receptors
    • Kenakin T.P. Efficacy at G protein coupled receptors. Annu. Rev. Pharmacol. Toxicol. 42:2002;349-379.
    • (2002) Annu. Rev. Pharmacol. Toxicol. , vol.42 , pp. 349-379
    • Kenakin, T.P.1
  • 44
  • 45
    • 0029787046 scopus 로고    scopus 로고
    • 2-adrenergic receptor
    • 2-adrenergic receptor. Mol. Pharmacol. 50:1996;662-666.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 662-666
    • Chidiac, P.1
  • 47
    • 0033569746 scopus 로고    scopus 로고
    • Spontaneous human B2 bradykinin receptor activity determines the action of partial agonists as agonists or inverse agonists
    • Fathy D.B., et al. Spontaneous human B2 bradykinin receptor activity determines the action of partial agonists as agonists or inverse agonists. J. Biol. Chem. 274:1999;29603-29606.
    • (1999) J. Biol. Chem. , vol.274 , pp. 29603-29606
    • Fathy, D.B.1
  • 48
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the Ghrelin receptor-identification of a potent inverse agonist
    • Holst B., et al. High constitutive signaling of the Ghrelin receptor-identification of a potent inverse agonist. Mol. Endocrinol. 17:2003;2201-2210.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 2201-2210
    • Holst, B.1
  • 50
    • 0035083109 scopus 로고    scopus 로고
    • Inverse, protean, and ligand-selective agonism: Matters of receptor conformation
    • Kenakin T.P. Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB J. 15:2001;598-611.
    • (2001) FASEB J. , vol.15 , pp. 598-611
    • Kenakin, T.P.1
  • 51
    • 0035958925 scopus 로고    scopus 로고
    • Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor
    • MacKinnon A.C., et al. Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. J. Biol. Chem. 276:2001;28083-28091.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28083-28091
    • MacKinnon, A.C.1
  • 52
    • 0033550046 scopus 로고    scopus 로고
    • Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via type 1 PTH receptor: Implications for design of signal-specific PTH ligands
    • Takasu H., et al. Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via type 1 PTH receptor: Implications for design of signal-specific PTH ligands. Biochemistry. 38:1999;13453-13460.
    • (1999) Biochemistry , vol.38 , pp. 13453-13460
    • Takasu, H.1
  • 53
    • 0030691760 scopus 로고    scopus 로고
    • μ Opioid receptor phosphorylation, desensitization, and ligand efficacy
    • Yu, Y. et al. (1997) μ Opioid receptor phosphorylation, desensitization, and ligand efficacy. J. Biol. Chem. 272, 28869-28874.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28869-28874
    • Yu, Y.1
  • 54
    • 0032574982 scopus 로고    scopus 로고
    • RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    • McLatchie L.M., et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 393:1998;333-339.
    • (1998) Nature , vol.393 , pp. 333-339
    • McLatchie, L.M.1
  • 55
    • 0036453601 scopus 로고    scopus 로고
    • GPCR drug discovery through the exploitation of allosteric drug binding sites
    • Rees S., et al. GPCR drug discovery through the exploitation of allosteric drug binding sites. Receptors Channels. 8:2002;261-268.
    • (2002) Receptors Channels , vol.8 , pp. 261-268
    • Rees, S.1
  • 56
    • 0029776693 scopus 로고    scopus 로고
    • Activation of muscarinic acetylcholine receptors via their allosteric binding sites
    • Jakubik J., et al. Activation of muscarinic acetylcholine receptors via their allosteric binding sites. Proc. Natl. Acad. Sci. U. S. A. 93:1996;8705-8709.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 8705-8709
    • Jakubik, J.1
  • 57
    • 0030793861 scopus 로고    scopus 로고
    • Co-Receptors for HIV-1 entry
    • Moore J.P., et al. Co-Receptors for HIV-1 entry. Curr. Opin. Immunol. 9:1997;551-562.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 551-562
    • Moore, J.P.1
  • 58
    • 0029758113 scopus 로고    scopus 로고
    • Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    • Nagasaw T., et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 382:1996;635-638.
    • (1996) Nature , vol.382 , pp. 635-638
    • Nagasaw, T.1
  • 59
    • 0032568336 scopus 로고    scopus 로고
    • Dissociation of the signalling and antiviral properties of SDF-1 derived small peptides
    • Heveker N., et al. Dissociation of the signalling and antiviral properties of SDF-1 derived small peptides. Curr. Biol. 8:1998;369-376.
    • (1998) Curr. Biol. , vol.8 , pp. 369-376
    • Heveker, N.1
  • 60
    • 0033578005 scopus 로고    scopus 로고
    • G-protein coupled receptor heterodimerization modulates receptor function
    • Jordan B.A., Jordan L.A. G-protein coupled receptor heterodimerization modulates receptor function. Nature. 399:1999;697-700.
    • (1999) Nature , vol.399 , pp. 697-700
    • Jordan, B.A.1    Jordan, L.A.2


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