-
2
-
-
46149128804
-
Towards a theory of innovation in services
-
Barras R (1986) Towards a theory of innovation in services. Research Policy 15:161-173.
-
(1986)
Research Policy
, vol.15
, pp. 161-173
-
-
Barras, R.1
-
3
-
-
78650797439
-
The covenant
-
September 16, 2010
-
Boyer PJ (2010) The covenant. The New Yorker, September 16, 2010. Available at: http://www.newyorker.com/reporting/2010/09/06/100906fa-fact-boyer.
-
(2010)
The New Yorker
-
-
Boyer, P.J.1
-
5
-
-
78649298936
-
Desperately seeking cures
-
May 15, 2010
-
Carmichael M and Begley S (2010) Desperately seeking cures. Newsweek, May 15, 2010, http://www.newsweek.com/2010/05/15/desperately-seeking-cures.html.
-
(2010)
Newsweek
-
-
Carmichael, M.1
Begley, S.2
-
7
-
-
78650791181
-
Biology 2.0. A special report on the human genome
-
June 19, 2010
-
Carr G (2010) Biology 2.0. A special report on the human genome. Economist, June 19, 2010.
-
(2010)
Economist
-
-
Carr, G.1
-
8
-
-
0037464588
-
A vision for the future of genomics research
-
US National Human Genome Research Institute
-
Collins FS, Green ED, Guttmacher AE, Guyer MS, and US National Human Genome Research Institute (2003) A vision for the future of genomics research. Nature 422:835-847.
-
(2003)
Nature
, vol.422
, pp. 835-847
-
-
Collins, F.S.1
Green, E.D.2
Guttmacher, A.E.3
Guyer, M.S.4
-
10
-
-
33750579770
-
Drug discovery in jeopardy
-
Cuatrecasas P (2006) Drug discovery in jeopardy. J Clin Invest 116:2837-2842.
-
(2006)
J Clin Invest
, vol.116
, pp. 2837-2842
-
-
Cuatrecasas, P.1
-
12
-
-
65649116136
-
Challenges in the search for drugs to treat central nervous system disorders
-
Enna SJ and Williams M (2009a) Challenges in the search for drugs to treat central nervous system disorders. J Pharmacol Exp Ther 329:404-411.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 404-411
-
-
Enna, S.J.1
Williams, M.2
-
13
-
-
77953146695
-
Defining the role of pharmacology in the emerging world of translational research
-
Enna SJ and Williams M (2009b) Defining the role of pharmacology in the emerging world of translational research. Adv Pharmacol 57:1-30.
-
(2009)
Adv Pharmacol
, vol.57
, pp. 1-30
-
-
Enna, S.J.1
Williams, M.2
-
14
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, et al. (2005) A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol 23:329-336.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
Biggs III, W.H.2
Treiber, D.K.3
Atteridge, C.E.4
Azimioara, M.D.5
Benedetti, M.G.6
Carter, T.A.7
Ciceri, P.8
Edeen, P.T.9
Floyd, M.10
-
15
-
-
77956474288
-
Do technical and commercial biases contribute to the pharmaceutical industry's productivity problems? An analysis of how reordering priorities can impact productivity
-
doi:10.1016/j.drudis.2010.06.010
-
Fryburg DA (2010) Do technical and commercial biases contribute to the pharmaceutical industry's productivity problems? An analysis of how reordering priorities can impact productivity. Drug Discov Today doi:10.1016/j.drudis.2010. 06.010.
-
(2010)
Drug Discov Today
-
-
Fryburg, D.A.1
-
16
-
-
78650762279
-
-
Simon and Schuster, New York
-
Goodwin F (2010) Fortune's Fool, Simon and Schuster, New York.
-
(2010)
Fortune's Fool
-
-
Goodwin, F.1
-
17
-
-
0037313517
-
Modern biomedical research: An internally self-consistent universe with little contact with medical reality?
-
Horrobin DF (2003) Modern biomedical research: an internally self-consistent universe with little contact with medical reality? Nat Rev Drug Discov 2:151-154.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 151-154
-
-
Horrobin, D.F.1
-
18
-
-
45549099294
-
Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B
-
Huang TC, Chang HY, Hsu CH, Kuo WH, Chang KJ, and Juan HF (2008) Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B. J Proteome Res 7:1433-1444.
-
(2008)
J Proteome Res
, vol.7
, pp. 1433-1444
-
-
Huang, T.C.1
Chang, H.Y.2
Hsu, C.H.3
Kuo, W.H.4
Chang, K.J.5
Juan, H.F.6
-
19
-
-
7244245762
-
Finishing the euchromatic sequence of the human genome
-
International Human Genome Sequencing Consortium.
-
International Human Genome Sequencing Consortium. (2004) Finishing the euchromatic sequence of the human genome. Nature 431:931-945.
-
(2004)
Nature
, vol.431
, pp. 931-945
-
-
-
20
-
-
49449105107
-
Molecular biology. Industrial-style screening meets academic biology
-
Kaiser J (2008) Molecular biology. Industrial-style screening meets academic biology. Science 321:764-766.
-
(2008)
Science
, vol.321
, pp. 764-766
-
-
Kaiser, J.1
-
21
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, Chan KW, Ciceri P, Davis MI, Edeen PT, et al. (2008) A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 26:127-132.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
Chan, K.W.7
Ciceri, P.8
Davis, M.I.9
Edeen, P.T.10
-
22
-
-
77954519891
-
Engineered allosteric activation of kinases in living cells
-
Karginov AV, Ding F, Kota P, Dokholyan NV, and Hahn KM (2010) Engineered allosteric activation of kinases in living cells. Nat Biotechnol 28:743-747.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 743-747
-
-
Karginov, A.V.1
Ding, F.2
Kota, P.3
Dokholyan, N.V.4
Hahn, K.M.5
-
23
-
-
85013943162
-
-
3rd ed, Academic Press, Burlington, MA
-
Kenakin TP (2009) A Pharmacology Primer, 3rd ed, pp. xv, Academic Press, Burlington, MA.
-
(2009)
A Pharmacology Primer
-
-
Kenakin, T.P.1
-
24
-
-
0043069489
-
Drug research: Myths, hype and reality
-
Kubinyi H (2003) Drug research: myths, hype and reality. Nat Rev Drug Discov 2:665-668.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 665-668
-
-
Kubinyi, H.1
-
25
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
DOI 10.1016/S0169-409X(00)00129-0, PII S0169409X00001290
-
Lipinski CA, Lombardo F, Dominy BW, and Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3-26. (Pubitemid 33653411)
-
(2000)
Advanced Drug Delivery Reviews
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
26
-
-
0026592648
-
Is molecular biology yet a science?
-
Maddox J (1992) Is molecular biology yet a science? Nature 355:201.
-
(1992)
Nature
, vol.355
, pp. 201
-
-
Maddox, J.1
-
27
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, and Sudarsanam S (2002) The protein kinase complement of the human genome. Science 298:1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
28
-
-
41649108196
-
Emerging opportunities for antipsychotic drug discovery in the postgenomic era
-
Marino MJ, Knutsen LJ, and Williams M (2008) Emerging opportunities for antipsychotic drug discovery in the postgenomic era. J Med Chem 51:1077-1107.
-
(2008)
J Med Chem
, vol.51
, pp. 1077-1107
-
-
Marino, M.J.1
Knutsen, L.J.2
Williams, M.3
-
29
-
-
67651174448
-
N-desmethylclozapine: Is there evidence for its antipsychotic potential?
-
Mendoza MC and Lindenmayer JP (2009) N-desmethylclozapine: is there evidence for its antipsychotic potential? Clin Neuropharmacol 32:154-157.
-
(2009)
Clin Neuropharmacol
, vol.32
, pp. 154-157
-
-
Mendoza, M.C.1
Lindenmayer, J.P.2
-
30
-
-
78650789325
-
-
Address to the Medical College of Virginia, Richmond, VA, Dec. 1, 1950. In Collins JC and Porras JI (2002), Harper Business Essentials, New York
-
Merck GW (1950) Address to the Medical College of Virginia, Richmond, VA, Dec. 1, 1950. In Collins JC and Porras JI (2002) Built to Last, p 49, Harper Business Essentials, New York.
-
(1950)
Built to Last
, pp. 49
-
-
Merck, G.W.1
-
31
-
-
77955114844
-
Is pharma running out of brainy ideas?
-
Miller G (2010) Is pharma running out of brainy ideas? Science 329:502-504.
-
(2010)
Science
, vol.329
, pp. 502-504
-
-
Miller, G.1
-
32
-
-
0041866256
-
Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists
-
Mirza NR, Peters D, and Sparks RG (2003) Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists. CNS Drug Rev 9:159-186.
-
(2003)
CNS Drug Rev
, vol.9
, pp. 159-186
-
-
Mirza, N.R.1
Peters, D.2
Sparks, R.G.3
-
33
-
-
34247144499
-
Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study
-
Morgan TM, Krumholz HM, Lifton RP, and Spertus JA (2007) Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. JAMA 297:1551-1561.
-
(2007)
JAMA
, vol.297
, pp. 1551-1561
-
-
Morgan, T.M.1
Krumholz, H.M.2
Lifton, R.P.3
Spertus, J.A.4
-
34
-
-
73449101512
-
Lessons from 60 years of pharmaceutical innovation
-
Munos B (2009) Lessons from 60 years of pharmaceutical innovation. Nat Rev Drug Discov 8:959-968.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 959-968
-
-
Munos, B.1
-
35
-
-
0036132019
-
Framework for managing development in the networked organisation
-
O'Sullivan D (2002) Framework for managing development in the networked organisation. Computers Industr 47:77-88.
-
(2002)
Computers Industr
, vol.47
, pp. 77-88
-
-
O'Sullivan, D.1
-
36
-
-
77149120471
-
Association between a literature-based genetic risk score and cardiovascular events in women
-
Paynter NP, Chasman DI, Paré G, Buring JE, Cook NR, Miletich JP, and Ridker PM (2010) Association between a literature-based genetic risk score and cardiovascular events in women. JAMA 303:631-637.
-
(2010)
JAMA
, vol.303
, pp. 631-637
-
-
Paynter, N.P.1
Chasman, D.I.2
Paré, G.3
Buring, J.E.4
Cook, N.R.5
Miletich, J.P.6
Ridker, P.M.7
-
39
-
-
4644271084
-
Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
-
Roth BL, Sheffler DJ, and Kroeze WK (2004) Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 3:353-359.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 353-359
-
-
Roth, B.L.1
Sheffler, D.J.2
Kroeze, W.K.3
-
41
-
-
67651191602
-
Drug research needs serendipity
-
July 29, 2008, Accessed 7/4/10
-
Shaywitz D and Taleb N (2008) Drug research needs serendipity. Financial Times, July 29, 2008. http://www.ft.com/cms/s/0/b735787c-5d9b-11dd-8129- 000077b07658.html. Accessed 7/4/10.
-
(2008)
Financial Times
-
-
Shaywitz, D.1
Taleb, N.2
-
42
-
-
42949149240
-
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
-
Tsai J, Lee JT, Wang W, Zhang J, Hanna Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, et al. (2008) Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA 105:3041-3046.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3041-3046
-
-
Tsai, J.1
Lee, J.T.2
Wang, W.3
Zhang, J.4
Hanna Cho, H.5
Mamo, S.6
Bremer, R.7
Gillette, S.8
Kong, J.9
Haass, N.K.10
-
43
-
-
54049120166
-
Drug discovery: Are productivity metrics inhibiting motivation and creativity?
-
Ullman F and Boutellier R (2008) Drug discovery: are productivity metrics inhibiting motivation and creativity? Drug Discov Today 13:997-1001.
-
(2008)
Drug Discov Today
, vol.13
, pp. 997-1001
-
-
Ullman, F.1
Boutellier, R.2
-
44
-
-
33846701641
-
Where is the optimism? Warrior teachings to regain the drug discovery spirit
-
Uitdehaag JC (2007) Where is the optimism? Warrior teachings to regain the drug discovery spirit. Drug Discov Today 12:105-107.
-
(2007)
Drug Discov Today
, vol.12
, pp. 105-107
-
-
Uitdehaag, J.C.1
-
45
-
-
67650069258
-
Assessing the translatability of drug projects: What needs to be scored to predict success?
-
Wehling M (2009) Assessing the translatability of drug projects: what needs to be scored to predict success? Nat Rev Drug Discov 8:541-546.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 541-546
-
-
Wehling, M.1
-
46
-
-
0028922794
-
Diagnosing the decline of major pharmaceutical research laboratories: A prescription for drug companies
-
Weisbach JA and Moos HW (1995) Diagnosing the decline of major pharmaceutical research laboratories: a prescription for drug companies. Drug Dev Res 34:243-259.
-
(1995)
Drug Dev Res
, vol.34
, pp. 243-259
-
-
Weisbach, J.A.1
Moos, H.W.2
-
47
-
-
77954656514
-
Beneficial effects of combining a type II ATP competitive inhibitor with an allosteric competitive inhibitor of BCR-ABL for the treatment of imatinib-sensitive and imatinib-resistant CML
-
Weisberg E, Deng X, Choi HG, Barrett R, Adamia S, Ray A, Moreno D, Kung AL, Gray N, and Griffin JD (2010) Beneficial effects of combining a type II ATP competitive inhibitor with an allosteric competitive inhibitor of BCR-ABL for the treatment of imatinib-sensitive and imatinib-resistant CML. Leukemia 24:1375-1378.
-
(2010)
Leukemia
, vol.24
, pp. 1375-1378
-
-
Weisberg, E.1
Deng, X.2
Choi, H.G.3
Barrett, R.4
Adamia, S.5
Ray, A.6
Moreno, D.7
Kung, A.L.8
Gray, N.9
Griffin, J.D.10
-
48
-
-
34548362105
-
Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development
-
Wess J, Eglen RM, and Gautam D (2007) Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 6:721-733.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 721-733
-
-
Wess, J.1
Eglen, R.M.2
Gautam, D.3
-
49
-
-
27744572131
-
Systems and integrative biology as alternative guises for pharmacology: Prime time for an iPharm concept?
-
Williams M (2005) Systems and integrative biology as alternative guises for pharmacology: prime time for an iPharm concept? Biochem Pharmacol 70:1707-1716.
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 1707-1716
-
-
Williams, M.1
-
50
-
-
70449475105
-
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
-
Zarrinkar PP, Gunawardane RN, Cramer MD, Gardner MF, Brigham D, Belli B, Karaman MW, Pratz KW, Pallares G, Chao Q, et al. (2009) AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 114:2984-2992.
-
(2009)
Blood
, vol.114
, pp. 2984-2992
-
-
Zarrinkar, P.P.1
Gunawardane, R.N.2
Cramer, M.D.3
Gardner, M.F.4
Brigham, D.5
Belli, B.6
Karaman, M.W.7
Pratz, K.W.8
Pallares, G.9
Chao, Q.10
-
51
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
Zhang J, Yang PL, and Gray NS (2009) Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 9:28-39.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
|