Oligomerisation of G-protein-coupled receptors

Journal of Cell Science

Volumn 114, Issue 7, 2001, Pages 1265-1271

  Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

G protein; Receptor; Signal transduction

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BETA ADRENERGIC RECEPTOR; BRADYKININ B2 RECEPTOR; CHAPERONIN; G PROTEIN COUPLED RECEPTOR; GENE PRODUCT; MUSCARINIC M3 RECEPTOR; OLIGOMER; OPIATE RECEPTOR;

ANIMAL CELL; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; DIMERIZATION; ENERGY TRANSFER; FLUORESCENCE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LUMINESCENCE; NONHUMAN; NOTE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

ANIMALS; CHAPERONINS; DIMERIZATION; GTP-BINDING PROTEINS; HUMANS; LIGANDS; OLIGOPEPTIDES; PRECIPITIN TESTS; RECEPTORS, CELL SURFACE; RECEPTORS, GABA;

ANIMALIA;

EID: 0035032316     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (66)

1. Abd Alla, S., Zaki, E., Lother, H. and Quitterer, U. (1999). Involvement of the amino terminus of the B(2) receptor in agonist-induced receptor dimerization. J. Biol. Chem. 274, 26079-26084.
2. 1- receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 407, 94-98.
3. 2-adrenergic receptor dimerization in living cells using bioluminescene resonance energy transfer (BRET). Proc. Nat. Acad. Sci. USA 97, 3684-3689.
4. Bockaert, J. and Pin, J. P. (1999). Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 18, 1723-1729.
5. Barbier, P., Colelli, A., Bolognesi, M. L., Minarini, A., Tumiatti, V., Corsini, G. U., Melchiorre, C. and Maggio, R. (1998). Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail. Eur. J. Pharmacol. 355, 267-274.
6. Cornea, A., Janovick, J. A., Maya-Nunez, G. and Conn, P. M. (2001).Gonadotropin releasing hormone microaggregation: rate monitored by fluorescence resonance energy transfer. J. Biol. Chem. 276, 2153-2158.
7. Cvejic, S. and Devi, L.A. (1997). Dimerization of the δ opioid receptor: implication for a role in receptor internalization. J Biol. Chem. 273, 26959-26964.
8. Fukushima, Y., Asano, T., Saitoh, T., Anai, M., Funaki, M., Ogihara, T., Katagiri, H., Matsuhashi, N., Yazaki, Y. and Sugano, K. (1997). Oligomer formation of histamine H2 receptors expressed in Sf9 and C0S7 cells. FEBS Lett. 409, 283-286.
9. George, S. R., Fan, T., Xie, Z., Tse, R., Tam, V., Varghese, G. and O'Dowd, B. F. (2000). Oligomerization of μ- and δ-opioid receptors. J. Biol. Chem. 275, 26128-26135.
10. Gines, S., Hillion, J., Torvinen, M., Le Crom, S., Casado, V., Canela, E. I., Rondin, S., Lew, J. Y., Watson, S., Zoli, M. et al. (2000). Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes. Proc. Nat. Acad. Sci. USA 97, 8606-8611.
11. Gouldson, P. R., Higgs, C., Smith, R. E, Dean, M. K., Gkoutos, G. V. and Reynolds, C. A. (2000). Dimerization and domain swapping in G-proteincoupled receptors: a computational study. Neuropsychopharmacology 23, S60-S77.
12. Grosse, R., Schoneberg, T., Schultz, G. and Gudermann, T. (1997).Inhibition of gonadotrophin-releasing hormone receptor signaling byexpression of a splice variant of the human receptor. Mol. Endocrinol. 11, 1305-1318.
13. Hall, R. A., Premont, R. T. and Lefkowitz, R. J. (1999). Heptahelical receptor signaling: beyond the G protein paradigm. J. Cell Biol. 145, 927-932.
14. 2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J. Biol. Chem. 271, 16384-16392.
15. 2AR through receptor dimerzation. Biochem. J. 330, 287-293.
16. Heuss, C. and Gerber, U. (2000). G-protein-independent signaling by Gprotein- coupled receptors. Trends Neurosci. 23, 469-475.
17. Hovius, R., Vallotton, P., Wohland, T. and Vogel, H. (2000). Fluorescence techniques: shedding light on ligand-receptor interactions. Trends Pharmacol. Sci. 21, 266-273.
18. Jones, K. A., Borowsky, B., Tamm, J. A., Craig, D. A., Durkin, M. M., Dai, M., Yao, W.-J., Johnson, M., Gunwaldsen, C., Huang, L.-Y. et al. (1998). GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2. Nature 396, 674-679.
19. Jordan, B. A. and Devi, L. A. (1999). G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399, 697-700.
20. Jordan, B. A., Trapaidze, N., Gomes, I., Nivarthi, R. and Devi, L. A. (2001). Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc. Nat. Acad. Sci. USA 98, 343-348.
21. Karpa, K. D., Lin, R., Kabbani, N. and Levenson, R. (2000). The dopamine D3 receptor interacts with itself and the truncated D3 splice variant D3nf: D3nf interaction causes mislocalization of D3 receptors. Mol. Pharmacol. 58, 677-683.
22. Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W. and Bettler, B. (1997). Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature 386, 239-246.
23. Kaupmann, K., Malitschek, B., Schuler, V., Heid, J., Froestl, W., Beck, P., Mosbacher, J., Bischoff, S., Kulik, A., Shigemoto, R. et al. (1998). GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature 396, 683-687.
24. Kuner, R., Kohr, G., Grunewald, S., Eisenhardt, G., Bach, A. and Kornau, H. C. (1999). Role of heteromer formation in GABAB receptor function. Science 283, 74-77.
25. Kunishima, N., Shimada, Y., Tsuji, Y., Sato, T., Yamamoto, M., Nakanishi, S., Jingami, H. and Morikawa, K. (2000). Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407, 971-977.
26. Lee, S. P., O'Dowd, B. F., Ng, G. Y., Varghese, G., Akil, H., Mansour, A., Nguyen, T. and George, S. R. (2000). Inhibitation of cell suface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell. Mol. Pharmacol. 58, 120-128.
27. McVey, M., Ramsay, D., Kellett, E., Rees, S., Wilson, S., Pope, A. J. and Milligan, G. (2001). Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer: the human δ opioid receptor displays constitutiveoligomerization at the cell surface which is not regulated by receptor occupancy. J. Biol. Chem. (in press).
28. Maggio, R., Vogel, Z. and Wess, J. (1993). Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular 'crosstalk' between G-protein-linked receptors. Proc. Nat. Acad. Sci. USA 90, 3103-3107.
29. Maggio, R., Barbier, P., Fornai, F. and Corsini, G. U. (1996). Functional role of the third cytoplasmic loop in muscarinic receptor dimerization. J.Biol. Chem. 271, 31055-31060.
30. Margeta-Mitrovic, M., Jan, Y. N. and Jan, L. Y. (2000). A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 27, 97-106.
31. B receptors - the first 7TM heterodimers. Trends Pharmacol. Sci. 20, 396-399.
32. Martin, S. C., Russek, S. J. and Farb, D. H. (1999). Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Mol. Cell. Neurosci. 13, 180-191.
33. 2- adrenoceptor antibody behave as antagonists. Mol. Pharmacol. 58, 373-379.
34. Milligan, G. (1998). New aspects of G protein-coupled receptor signaling and regulation. Trends Endocrinol. Metab. 9, 13-19.
35. Milligan, G. (2000). Receptors as kissing cousins. Science 288, 65-67.
36. Milligan, G. and Rees, S. (2000). Oligomerisation of G protein-coupled receptors. Annu. Rep. Med. Chem. 35, 271-279.
37. B receptors make it to the top - as dimers. Trends Pharmacol. Sci. 20, 87-89.
38. Monnot, C., Bihoreau, C., Conchon, S., Curnow, K. M., Corvol, P. and Clauser, E. (1996). Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants. J. Biol. Chem. 271, 1507-1513.
39. Morello, J. P., Salahpour, A., Laperriere, A., Bernier, V., Arthus, M. F., Lonergan, M., Petaja-Repo, U., Angers, S., Morin, D., Bichet, D. G. and Bouvier, M. (2000). Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants. J. Clin. Invest. 105, 887-895.
40. Nakanishi-Matsui, M., Zheng, Y.-W., Suiciner, D. J., Weiss, E. J., Ludeman, M. J. and Coughlin, S. R. (2000). PAR3 is a cofactor for PAR4 activation by thrombin. Nature 404, 609-613.
41. Ng, G.Y., O'Dowd, B. F., Lee, S. P., Chung, H. T., Brann, M. R., Seeman, P., George, S. R. (1996). Dopamine D2 receptor dimers and receptorblocking peptides. Biochem. Biophys. Res. Commun. 227, 200-204.
42. Ng, G.Y., Clark, J., Coulombe, N., Ethier, N., Hebert, T. E., Sullivan, R., Kargman, S., Chateauneuf, A., Tsukamoto, N., McDonald, T. et al. (1999). Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. J. Biol. Chem. 274, 7607-7610.
43. 3 receptor dimers and tetramers in brain and in transfected cells. J. Biol. Chem. 272, 29229-29237.
44. O'Brien, P. J., Prevost, N., Molino, M. M., Hollinger, K., Woolkalis, M. J., Woulfe, D. S. and Brass, L. F. (2000). Thrombin responses in human endothelial cells. J. Biol. Chem. 275, 13502-13509.
45. Overton, M. C. and Blumer, K. J. (2000). G-protein-coupled receptors function as oligomers in vivo. Curr. Biol. 10, 341-344.
46. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E. et al. (2000). Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745.
47. Petaja-Repo, U. E., Hogue, M., Laperriere, A., Walker, P. and Bouvier, M.(2000). Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor. J. Biol. Chem. 275, 13727-13736.
48. Pollock, B. A. and Heim, R. (1999). Using GFP in FRET-based applications. Trends Cell Biol. 9, 57-60.
49. Ray, K. and Hauschild, B. C. (2000). Cys-140 is critical for metabotrophic glutamate receptor-1 (mGluR-1) dimerization. J. Biol. Chem. 275, 34245-34251.
50. Rocheville, M., Lange, D. C., Kumar, U., Sasi, R., Patel, R. C. and Patel, Y. C. (2000a). Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J. Biol. Chem. 275, 7862-7869.
51. Rocheville, M., Lange, D. C., Kumar, U., Patel, S. C., Patel, R. C. and Patel, Y. C. (2000b). Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288, 154-157.
52. Rodriguez-Frade, J. M., Vila-Coro, A. J., Martin De Ana, A., Albar, J. P., Martinez, A. C. and Mellado, M. (1999). The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2. Proc. Nat. Acad. Sci. USA 96, 3628-3633.
53. Romano, C., Yang, W.-L. and O'Malley, K. L. (1996). Metabolic glutamate Receptor 5 Is a disulfide-linked dimer. J. Biol. Chem. 271, 28612-28616.
54. Romano, C., Miller, J. K., Hyrc, K., Dikranian, S., Mennerick, S., Takeuchi, Y., Goldberg. M. P. and O'Malley, K. L. (2001). Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu(5) dimerization. Mol. Pharmacol. 59, 46-53.
55. Salapour, A., Angers, S. and Bovier, M. (2000). Functional significance of oligomerization of G-protein-coupled receptors. Trends Endocrinol. Metab. 11, 163-168.
56. Scarselli, M., Armogida, M., Chiacchio, S., DeMontis, M. G., Colzi, A., Corsini, G. U. and Maggio, R. (2000). Reconstitution of functional dopamine D(2s) receptor by co-expression of amino and carboxyl-terminal receptor fragments. Eur. J. Pharmacol. 397, 291-296.
57. Schoneberg, T., Yun, J., Wenkert, D. and Wess, J. (1996). Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide. EMBO J. 15, 1283-1291.
58. Schulz, A., Grosse, R., Schultz, G., Gudermann, T. and Schoneberg, T. (2000). Structural implication for receptor oligomerization from functional reconstitution studies of mutant V2 vasopressin receptors. J. Biol. Chem. 275, 2381-2389.
59. Tsuji, Y., Shimada, Y., Takeshita, T., Kajimura, N., Nomura, S., Sekiyama, N., Otomo, J., Usukura, J., Nakanishi, S. and Jingami, H. (2000). Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1. J. Biol. Chem. 275, 28144-28151.
60. Vila-Coro, A. J., Rodriguez-Frade, J. M., Martin De Ana, A., Moreno- Ortiz, M. C., Martinez, A. C. and Mellado, M. (1999). The chemokine SDF-1a triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J. 13, 1699-1710.
61. Vila-Coro, A. J., Mellado, M., Martin de Ana, A., Lucas, P., del Real, G., Martinez, A. C. and Rodriguez-Frade, J. M. (2000). HIV-1 infection through the CCR5 is blocked by receptor dimerization. Proc. Nat. Acad. Sci. USA 97, 3388-3393.
62. White, J. H., Wise, A., Main, M. J., Green, A., Fraser, N. J., Disney, G. H., Barnes, A. A., Emson, P., Foord, S. M. and Marshall, F. H. (1998).Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396, 679-682.
63. Wilson, S., Bergsma, D. J., Chambers, J. K., Muir, A. I., Fantom, K. G., Ellis, C., Murdock, P. R., Herrity, N. C. and Stadel, J. M. (1998). Orphan G-protein-coupled receptors: the next generation of drug targets? Br. J. Pharmacol. 125, 1387-1392.
64. Yesilaltay, A. and Jenness, D. D. (2000). Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis. Mol. Biol. Cell 11, 2873-2884.
65. Zeng, F.-Y. and Wess, J. (1999). Identification and molecular characterization of m3 muscarinic receptor dimers. J. Biol. Chem. 274, 19487-19497.
66. Zhu, X. and Wess, J. (1998). Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry 37, 15773-15784.