-
1
-
-
33644527950
-
The model organism as a system: Integrating 'omics' data sets
-
Joyce AR, Palsson BO (2006) The model organism as a system: Integrating 'omics' data sets. Nat Rev Mol Cell Biol 7:198-210.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 198-210
-
-
Joyce, A.R.1
Palsson, B.O.2
-
2
-
-
33646352962
-
Potent antibody therapeutics by design
-
Carter PJ (2006) Potent antibody therapeutics by design. Nat Rev Immunol 6:343-357.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 343-357
-
-
Carter, P.J.1
-
3
-
-
43049123356
-
Advances in laboratory evolution of enzymes
-
Bershtein S, Tawfik DS (2008) Advances in laboratory evolution of enzymes. Curr Opin Chem Biol 12:151-158.
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 151-158
-
-
Bershtein, S.1
Tawfik, D.S.2
-
4
-
-
38749148516
-
Synthetic biology for synthetic chemistry
-
Keasling JD (2008) Synthetic biology for synthetic chemistry. ACS Chem Biol 3:64-76.
-
(2008)
ACS Chem Biol
, vol.3
, pp. 64-76
-
-
Keasling, J.D.1
-
5
-
-
36749020130
-
Protein engineers turned evolutionists
-
Peisajovich SG, Tawfik DS (2007) Protein engineers turned evolutionists. Nat Methods 4:991-994.
-
(2007)
Nat Methods
, vol.4
, pp. 991-994
-
-
Peisajovich, S.G.1
Tawfik, D.S.2
-
6
-
-
0025074907
-
In vitro selection of RNA molecules that bind specific ligands
-
Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346:818-822.
-
(1990)
Nature
, vol.346
, pp. 818-822
-
-
Ellington, A.D.1
Szostak, J.W.2
-
7
-
-
0028291823
-
Isolation of high affinity human antibodies directly from large synthetic repertoires
-
Griffiths AD, et al. (1994) Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J 13:3245-3260.
-
(1994)
EMBO J
, vol.13
, pp. 3245-3260
-
-
Griffiths, A.D.1
-
8
-
-
0042926892
-
Phage display as a tool for the directed evolution of enzymes
-
Fernandez-Gacio A, Uguen M, Fastrez J (2003) Phage display as a tool for the directed evolution of enzymes. Trends Biotechnol 21:408-414.
-
(2003)
Trends Biotechnol
, vol.21
, pp. 408-414
-
-
Fernandez-Gacio, A.1
Uguen, M.2
Fastrez, J.3
-
9
-
-
33747130345
-
Miniaturising the laboratory in emulsion droplets
-
Griffiths AD, Tawfik DS (2006) Miniaturising the laboratory in emulsion droplets. Trends Biotechnol 24:395-402.
-
(2006)
Trends Biotechnol
, vol.24
, pp. 395-402
-
-
Griffiths, A.D.1
Tawfik, D.S.2
-
10
-
-
56649111369
-
Highly l and d enantioselective variants of horseradish peroxidase discovered by an ultrahigh-throughput selection method
-
Antipov E, Cho AE, Wittrup KD, Klibanov AM (2008) Highly l and d enantioselective variants of horseradish peroxidase discovered by an ultrahigh-throughput selection method. Proc Natl Acad Sci USA 105:17694-17699.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17694-17699
-
-
Antipov, E.1
Cho, A.E.2
Wittrup, K.D.3
Klibanov, A.M.4
-
11
-
-
0042707768
-
Screening for content-the evolution of high throughput
-
Dove A (2003) Screening for content-the evolution of high throughput. Nat Biotechnol 21:859-864.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 859-864
-
-
Dove, A.1
-
12
-
-
0037131390
-
Microfluidic Large-Scale Integration
-
Thorsen T, Maerkl SJ, Quake SR (2002) Microfluidic Large-Scale Integration. Science 298:580-584.
-
(2002)
Science
, vol.298
, pp. 580-584
-
-
Thorsen, T.1
Maerkl, S.J.2
Quake, S.R.3
-
14
-
-
0033988843
-
Fabrication of microfluidic systems in poly(dimethylsiloxane)
-
McDonald JC, et al. (2000) Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21:27-40.
-
(2000)
Electrophoresis
, vol.21
, pp. 27-40
-
-
McDonald, J.C.1
-
15
-
-
52649177297
-
Biocompatible surfactants for water-in-fluorocarbon emulsions
-
Holtze C, et al. (2008) Biocompatible surfactants for water-in-fluorocarbon emulsions. Lab Chip 8:1632-1639.
-
(2008)
Lab Chip
, vol.8
, pp. 1632-1639
-
-
Holtze, C.1
-
16
-
-
33947184356
-
Quantitative detection of protein expression in single cells using droplet microfluidics
-
Huebner A, et al. (2007) Quantitative detection of protein expression in single cells using droplet microfluidics. Chem Commun 1218-1220.
-
(2007)
Chem Commun
, pp. 1218-1220
-
-
Huebner, A.1
-
17
-
-
67649973848
-
Fluorescence-activated droplet sorting (FADS): Efficient microfluidic cell sorting based on enzymatic activity
-
Baret J, et al. (2009) Fluorescence-activated droplet sorting (FADS): Efficient microfluidic cell sorting based on enzymatic activity. Lab Chip 9:1850-1858.
-
(2009)
Lab Chip
, vol.9
, pp. 1850-1858
-
-
Baret, J.1
-
18
-
-
30744474931
-
-
Ahn K, et al. (2006) Dielectrophoretic manipulation of drops for high-speed microfluidic sorting devices. Appl Phys Lett 88:024104-1-3.
-
Ahn K, et al. (2006) Dielectrophoretic manipulation of drops for high-speed microfluidic sorting devices. Appl Phys Lett 88:024104-1-3.
-
-
-
-
19
-
-
0742324902
-
Horseradish peroxidase: A modern view of a classic enzyme
-
Veitch NC (2004) Horseradish peroxidase: A modern view of a classic enzyme. Phytochemistry 65:249-259.
-
(2004)
Phytochemistry
, vol.65
, pp. 249-259
-
-
Veitch, N.C.1
-
20
-
-
0031573401
-
A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: Applications in detecting the activity of phagocyte NADPH oxidase and other oxidases
-
Zhou M, Diwu Z, Panchuk-Voloshina N, Haugland RP (1997) A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: Applications in detecting the activity of phagocyte NADPH oxidase and other oxidases. Anal Biochem 253:162-168.
-
(1997)
Anal Biochem
, vol.253
, pp. 162-168
-
-
Zhou, M.1
Diwu, Z.2
Panchuk-Voloshina, N.3
Haugland, R.P.4
-
21
-
-
44349161622
-
Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins
-
Bershtein S, Goldin K, Tawfik DS (2008) Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins. J Mol Biol 379:1029-1044.
-
(2008)
J Mol Biol
, vol.379
, pp. 1029-1044
-
-
Bershtein, S.1
Goldin, K.2
Tawfik, D.S.3
-
22
-
-
54149114377
-
Ohno's model revisited: Measuring the frequency of potentially adaptive mutations under various mutational drifts
-
Bershtein S, Tawfik DS (2008) Ohno's model revisited: Measuring the frequency of potentially adaptive mutations under various mutational drifts. Mol Biol Evol 25:2311-2318.
-
(2008)
Mol Biol Evol
, vol.25
, pp. 2311-2318
-
-
Bershtein, S.1
Tawfik, D.S.2
-
23
-
-
45849093668
-
Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli
-
Blount ZD, Borland CZ, Lenski RE (2008) Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. Proc Natl Acad Sci USA 105:7899-7906.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7899-7906
-
-
Blount, Z.D.1
Borland, C.Z.2
Lenski, R.E.3
-
24
-
-
18144403554
-
Improving enzyme properties: When are closer mutations better?
-
Morley KL, Kazlauskas RJ (2005) Improving enzyme properties: When are closer mutations better?. Trends Biotechnol 23:231-237.
-
(2005)
Trends Biotechnol
, vol.23
, pp. 231-237
-
-
Morley, K.L.1
Kazlauskas, R.J.2
-
25
-
-
0037161809
-
The catalytic pathway of horseradish peroxidase at high resolution
-
Berglund GI, et al. (2002) The catalytic pathway of horseradish peroxidase at high resolution. Nature 417:463-468.
-
(2002)
Nature
, vol.417
, pp. 463-468
-
-
Berglund, G.I.1
-
26
-
-
0001463548
-
Nonparametric estimation of the number of classes in a population
-
Chao A (1984) Nonparametric estimation of the number of classes in a population. Scand J Stat 11:265-270.
-
(1984)
Scand J Stat
, vol.11
, pp. 265-270
-
-
Chao, A.1
-
27
-
-
0034842869
-
Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae
-
Morawski B, Quan S, Arnold FH (2001) Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae. Biotechnol Bioeng 76:99-107.
-
(2001)
Biotechnol Bioeng
, vol.76
, pp. 99-107
-
-
Morawski, B.1
Quan, S.2
Arnold, F.H.3
-
28
-
-
33745613020
-
-
Ahn K, Agresti JJ, Chong H, Marquez M, Weitz DA (2006) Electrocoalescence of drops synchronized by size-dependent flow in microfluidic channels. Appl Phys Lett 88:264105-1-3.
-
Ahn K, Agresti JJ, Chong H, Marquez M, Weitz DA (2006) Electrocoalescence of drops synchronized by size-dependent flow in microfluidic channels. Appl Phys Lett 88:264105-1-3.
-
-
-
-
29
-
-
37549015666
-
Bell's law for the birth and death of computer classes
-
Bell G (2008) Bell's law for the birth and death of computer classes. Commun ACM 51:86-94.
-
(2008)
Commun ACM
, vol.51
, pp. 86-94
-
-
Bell, G.1
-
30
-
-
35349015204
-
Selection of horseradish peroxidase variants with enhanced enantioselectivity by yeast surface display
-
Lipovsek D, et al. (2007) Selection of horseradish peroxidase variants with enhanced enantioselectivity by yeast surface display. Chem Biol 14:1176-1185.
-
(2007)
Chem Biol
, vol.14
, pp. 1176-1185
-
-
Lipovsek, D.1
-
31
-
-
0031909113
-
Molecular evolution by staggered extension process (StEP) in vitro recombination
-
Zhao H, Giver L, Shao Z, Affholter JA, Arnold FH (1998) Molecular evolution by staggered extension process (StEP) in vitro recombination. Nat Biotechnol 16:258-261.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 258-261
-
-
Zhao, H.1
Giver, L.2
Shao, Z.3
Affholter, J.A.4
Arnold, F.H.5
-
32
-
-
53249120657
-
Cofabrication of electromagnets and microfluidic systems in poly(dimethylsiloxane)13
-
Siegel AC, et al. (2006) Cofabrication of electromagnets and microfluidic systems in poly(dimethylsiloxane)13. Angew Chem-Ger Edit 118:7031-7036.
-
(2006)
Angew Chem-Ger Edit
, vol.118
, pp. 7031-7036
-
-
Siegel, A.C.1
-
33
-
-
0037455351
-
Formation of dispersions using "flow focusing" in microchannels
-
Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using "flow focusing" in microchannels. Appl Phys Lett 82:364-366.
-
(2003)
Appl Phys Lett
, vol.82
, pp. 364-366
-
-
Anna, S.L.1
Bontoux, N.2
Stone, H.A.3
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