-
1
-
-
33644889108
-
Allosteric inhibitors of Bcr-abl-dependent cell proliferation
-
F.J. Adrián, Q. Ding, T.B. Sim, A. Velentza, C. Sloan, Y. Liu, G.B. Zhang, W. Hur, S. Ding, and P. Manley Allosteric inhibitors of Bcr-abl-dependent cell proliferation Nat. Chem. Biol. 2 2006 95 102
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 95-102
-
-
Adrián, F.J.1
Ding, Q.2
Sim, T.B.3
Velentza, A.4
Sloan, C.5
Liu, Y.6
Zhang, G.B.7
Hur, W.8
Ding, S.9
Manley, P.10
-
2
-
-
34447270267
-
Polovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase
-
A. Autret, S. Martin-Latil, L. Mousson, A. Wirotius, F. Petit, D. Arnoult, F. Colbere-Garapin, J. Estaquier, and B. Blondel Polovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase J. Virol. 81 2007 7504 7516
-
(2007)
J. Virol.
, vol.81
, pp. 7504-7516
-
-
Autret, A.1
Martin-Latil, S.2
Mousson, L.3
Wirotius, A.4
Petit, F.5
Arnoult, D.6
Colbere-Garapin, F.7
Estaquier, J.8
Blondel, B.9
-
3
-
-
53549104402
-
Activation of tyrosine kinases by mutation of the gatekeeper threonine
-
M. Azam, M.A. Seeliger, N.S. Gray, J. Kuriyan, and G.Q. Daley Activation of tyrosine kinases by mutation of the gatekeeper threonine Nat. Struct. Mol. Biol. 15 2008 1109 1118
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 1109-1118
-
-
Azam, M.1
Seeliger, M.A.2
Gray, N.S.3
Kuriyan, J.4
Daley, G.Q.5
-
4
-
-
70350340728
-
The role of dynamic conformational ensembles in biomolecular recognition
-
D.D. Boehr, R. Nussinov, and P.E. Wright The role of dynamic conformational ensembles in biomolecular recognition Nat. Chem. Biol. 5 2009 789 796
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 789-796
-
-
Boehr, D.D.1
Nussinov, R.2
Wright, P.E.3
-
5
-
-
74549149999
-
Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure
-
J.A. Capra, R.A. Laskowski, J.M. Thornton, M. Singh, and T.A. Funkhouser Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure PLoS. Comput. Biol. 5 2009 e1000585
-
(2009)
PLoS. Comput. Biol.
, vol.5
, pp. 1000585
-
-
Capra, J.A.1
Laskowski, R.A.2
Thornton, J.M.3
Singh, M.4
Funkhouser, T.A.5
-
6
-
-
84861219631
-
Allostery and the Monod-Wyman-Changeux model after 50 years
-
J.P. Changeux Allostery and the Monod-Wyman-Changeux model after 50 years Annu. Rev. Biophys. 41 2012 103 133
-
(2012)
Annu. Rev. Biophys.
, vol.41
, pp. 103-133
-
-
Changeux, J.P.1
-
7
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
V. Cherezov, D.M. Rosenbaum, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.J. Choi, P. Kuhn, W.I. Weis, B.K. Kobilka, and R.C. Stevens High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor Science 318 2007 1258 1265
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.F.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
Stevens, R.C.11
-
8
-
-
79952790513
-
Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97
-
C.N. Chi, A. Bach, Å. Engström, K. Strømgaard, P. Lundström, N. Ferguson, and P. Jemth Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97 J. Biol. Chem. 286 2011 3597 3606
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 3597-3606
-
-
Chi, C.N.1
Bach, A.2
Engström, Å.3
Strømgaard, K.4
Lundström, P.5
Ferguson, N.6
Jemth, P.7
-
9
-
-
58149193205
-
Allosteric modulators of GPCRs: A novel approach for the treatment of CNS disorders
-
P.J. Conn, A. Christopoulos, and C.W. Lindsley Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders Nat. Rev. Drug Discov. 8 2009 41 54
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 41-54
-
-
Conn, P.J.1
Christopoulos, A.2
Lindsley, C.W.3
-
10
-
-
77957231785
-
Induced fit, conformational selection and independent dynamic segments: An extended view of binding events
-
P. Csermely, R. Palotai, and R. Nussinov Induced fit, conformational selection and independent dynamic segments: an extended view of binding events Trends Biochem. Sci. 35 2010 539 546
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 539-546
-
-
Csermely, P.1
Palotai, R.2
Nussinov, R.3
-
11
-
-
48249141040
-
Allostery and cooperativity revisited
-
Q. Cui, and M. Karplus Allostery and cooperativity revisited Protein Sci. 17 2008 1295 1307
-
(2008)
Protein Sci.
, vol.17
, pp. 1295-1307
-
-
Cui, Q.1
Karplus, M.2
-
12
-
-
68149157248
-
The origin of allosteric functional modulation: Multiple pre-existing pathways
-
A. del Sol, C.J. Tsai, B.Y. Ma, and R. Nussinov The origin of allosteric functional modulation: multiple pre-existing pathways Structure 17 2009 1042 1050
-
(2009)
Structure
, vol.17
, pp. 1042-1050
-
-
Del Sol, A.1
Tsai, C.J.2
Ma, B.Y.3
Nussinov, R.4
-
13
-
-
58849089256
-
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding
-
X.M. Deng, F.Q. Gao, and W.S. May Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding Blood 113 2009 422 428
-
(2009)
Blood
, vol.113
, pp. 422-428
-
-
Deng, X.M.1
Gao, F.Q.2
May, W.S.3
-
14
-
-
77957930406
-
Expanding the diversity of allosteric bcr-abl inhibitors
-
X.M. Deng, B. Okram, Q.A. Ding, J.M. Zhang, Y.M. Choi, F.J. Adrián, A. Wojciechowski, G.B. Zhang, J.W. Che, and B. Bursulaya Expanding the diversity of allosteric bcr-abl inhibitors J. Med. Chem. 53 2010 6934 6946
-
(2010)
J. Med. Chem.
, vol.53
, pp. 6934-6946
-
-
Deng, X.M.1
Okram, B.2
Ding, Q.A.3
Zhang, J.M.4
Choi, Y.M.5
Adrián, F.J.6
Wojciechowski, A.7
Zhang, G.B.8
Che, J.W.9
Bursulaya, B.10
-
15
-
-
77953292595
-
Post-translational modifications in signal integration
-
Y.L. Deribe, T. Pawson, and I. Dikic Post-translational modifications in signal integration Nat. Struct. Mol. Biol. 17 2010 666 672
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 666-672
-
-
Deribe, Y.L.1
Pawson, T.2
Dikic, I.3
-
16
-
-
23744452229
-
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site
-
S. Di Marco, C. Volpari, L. Tomei, S. Altamura, S. Harper, F. Narjes, U. Koch, M. Rowley, R. De Francesco, G. Migliaccio, and A. Carfí Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site J. Biol. Chem. 280 2005 29765 29770
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29765-29770
-
-
Di Marco, S.1
Volpari, C.2
Tomei, L.3
Altamura, S.4
Harper, S.5
Narjes, F.6
Koch, U.7
Rowley, M.8
De Francesco, R.9
Migliaccio, G.10
Carfí, A.11
-
17
-
-
1842298212
-
From Levinthal to pathways to funnels
-
K.A. Dill, and H.S. Chan From Levinthal to pathways to funnels Nat. Struct. Biol. 4 1997 10 19
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 10-19
-
-
Dill, K.A.1
Chan, H.S.2
-
18
-
-
84860390423
-
Regulation of the catalytic activity of the EGF receptor
-
N.F. Endres, K. Engel, R. Das, E. Kovacs, and J. Kuriyan Regulation of the catalytic activity of the EGF receptor Curr. Opin. Struct. Biol. 21 2011 777 784
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 777-784
-
-
Endres, N.F.1
Engel, K.2
Das, R.3
Kovacs, E.4
Kuriyan, J.5
-
19
-
-
82455179494
-
Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles
-
R.B. Fenwick, S. Esteban-Martín, and X. Salvatella Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles Eur. Biophys. J. 40 2011 1339 1355
-
(2011)
Eur. Biophys. J.
, vol.40
, pp. 1339-1355
-
-
Fenwick, R.B.1
Esteban-Martín, S.2
Salvatella, X.3
-
20
-
-
75749100247
-
Poised transcription factories prime silent uPA gene prior to activation
-
C. Ferrai, S.Q. Xie, P. Luraghi, D. Munari, F. Ramirez, M.R. Branco, A. Pombo, and M.P. Crippa Poised transcription factories prime silent uPA gene prior to activation PLoS Biol. 8 2010 e1000270
-
(2010)
PLoS Biol.
, vol.8
, pp. 1000270
-
-
Ferrai, C.1
Xie, S.Q.2
Luraghi, P.3
Munari, D.4
Ramirez, F.5
Branco, M.R.6
Pombo, A.7
Crippa, M.P.8
-
21
-
-
0026320866
-
The energy landscapes and motions of proteins
-
H. Frauenfelder, S.G. Sligar, and P.G. Wolynes The energy landscapes and motions of proteins Science 254 1991 1598 1603
-
(1991)
Science
, vol.254
, pp. 1598-1603
-
-
Frauenfelder, H.1
Sligar, S.G.2
Wolynes, P.G.3
-
22
-
-
82655180384
-
Fuzziness: Linking regulation to protein dynamics
-
M. Fuxreiter Fuzziness: linking regulation to protein dynamics Mol. Biosyst. 8 2012 168 177
-
(2012)
Mol. Biosyst.
, vol.8
, pp. 168-177
-
-
Fuxreiter, M.1
-
23
-
-
84855418058
-
Identification of specific tethered inhibitors for caspase-5
-
J.J. Gao, and J.A. Wells Identification of specific tethered inhibitors for caspase-5 Chem. Biol. Drug Des. 79 2012 209 215
-
(2012)
Chem. Biol. Drug Des.
, vol.79
, pp. 209-215
-
-
Gao, J.J.1
Wells, J.A.2
-
24
-
-
0037050026
-
Functional organization of the yeast proteome by systematic analysis of protein complexes
-
A.C. Gavin, M. Bösche, R. Krause, P. Grandi, M. Marzioch, A. Bauer, J. Schultz, J.M. Rick, A.M. Michon, and C.M. Cruciat Functional organization of the yeast proteome by systematic analysis of protein complexes Nature 415 2002 141 147
-
(2002)
Nature
, vol.415
, pp. 141-147
-
-
Gavin, A.C.1
Bösche, M.2
Krause, R.3
Grandi, P.4
Marzioch, M.5
Bauer, A.6
Schultz, J.7
Rick, J.M.8
Michon, A.M.9
Cruciat, C.M.10
-
25
-
-
62149128986
-
The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
-
M. Good, G. Tang, J. Singleton, A. Reményi, and W.A. Lim The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation Cell 136 2009 1085 1097
-
(2009)
Cell
, vol.136
, pp. 1085-1097
-
-
Good, M.1
Tang, G.2
Singleton, J.3
Reményi, A.4
Lim, W.A.5
-
26
-
-
79955770162
-
Scaffold proteins: Hubs for controlling the flow of cellular information
-
M.C. Good, J.G. Zalatan, and W.A. Lim Scaffold proteins: hubs for controlling the flow of cellular information Science 332 2011 680 686
-
(2011)
Science
, vol.332
, pp. 680-686
-
-
Good, M.C.1
Zalatan, J.G.2
Lim, W.A.3
-
27
-
-
47649125643
-
Allosteric regulation and catalysis emerge via a common route
-
N.M. Goodey, and S.J. Benkovic Allosteric regulation and catalysis emerge via a common route Nat. Chem. Biol. 4 2008 474 482
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 474-482
-
-
Goodey, N.M.1
Benkovic, S.J.2
-
28
-
-
0030049479
-
Pre-steady-state kinetic analysis of cAMP-dependent protein kinase using rapid quench flow techniques
-
B.D. Grant, and J.A. Adams Pre-steady-state kinetic analysis of cAMP-dependent protein kinase using rapid quench flow techniques Biochemistry 35 1996 2022 2029
-
(1996)
Biochemistry
, vol.35
, pp. 2022-2029
-
-
Grant, B.D.1
Adams, J.A.2
-
29
-
-
6344219895
-
Is allostery an intrinsic property of all dynamic proteins?
-
K. Gunasekaran, B.Y. Ma, and R. Nussinov Is allostery an intrinsic property of all dynamic proteins? Proteins 57 2004 433 443
-
(2004)
Proteins
, vol.57
, pp. 433-443
-
-
Gunasekaran, K.1
Ma, B.Y.2
Nussinov, R.3
-
30
-
-
84863393353
-
Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies
-
M. Gupta, A.E.W. Hendrickson, S.S. Yun, J.J. Han, P.A. Schneider, B.D. Koh, M.J. Stenson, L.E. Wellik, J.C. Shing, and K.L. Peterson Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies Blood 119 2012 476 487
-
(2012)
Blood
, vol.119
, pp. 476-487
-
-
Gupta, M.1
Hendrickson, A.E.W.2
Yun, S.S.3
Han, J.J.4
Schneider, P.A.5
Koh, B.D.6
Stenson, M.J.7
Wellik, L.E.8
Shing, J.C.9
Peterson, K.L.10
-
33
-
-
0037013143
-
The conformational plasticity of protein kinases
-
M. Huse, and J. Kuriyan The conformational plasticity of protein kinases Cell 109 2002 275 282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
34
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
C.M. Johannessen, J.S. Boehm, S.Y. Kim, S.R. Thomas, L. Wardwell, L.A. Johnson, C.M. Emery, N. Stransky, A.P. Cogdill, and J. Barretina COT drives resistance to RAF inhibition through MAP kinase pathway reactivation Nature 468 2010 968 972
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
Thomas, S.R.4
Wardwell, L.5
Johnson, L.A.6
Emery, C.M.7
Stransky, N.8
Cogdill, A.P.9
Barretina, J.10
-
35
-
-
77957231335
-
Identification of an allosteric signaling network within Tec family kinases
-
R.E. Joseph, Q.A. Xie, and A.H. Andreotti Identification of an allosteric signaling network within Tec family kinases J. Mol. Biol. 403 2010 231 242
-
(2010)
J. Mol. Biol.
, vol.403
, pp. 231-242
-
-
Joseph, R.E.1
Xie, Q.A.2
Andreotti, A.H.3
-
36
-
-
79953308071
-
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms
-
N. Jura, X.W. Zhang, N.F. Endres, M.A. Seeliger, T. Schindler, and J. Kuriyan Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms Mol. Cell 42 2011 9 22
-
(2011)
Mol. Cell
, vol.42
, pp. 9-22
-
-
Jura, N.1
Zhang, X.W.2
Endres, N.F.3
Seeliger, M.A.4
Schindler, T.5
Kuriyan, J.6
-
38
-
-
69649097791
-
'7TM receptor allostery: Putting numbers to shapeshifting proteins
-
T.P. Kenakin '7TM receptor allostery: putting numbers to shapeshifting proteins Trends Pharmacol. Sci. 30 2009 460 469
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 460-469
-
-
Kenakin, T.P.1
-
39
-
-
77952354490
-
Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
-
T. Kenakin, and L.J. Miller Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery Pharmacol. Rev. 62 2010 265 304
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 265-304
-
-
Kenakin, T.1
Miller, L.J.2
-
41
-
-
24944497371
-
Features of selective kinase inhibitors
-
Z.A. Knight, and K.M. Shokat Features of selective kinase inhibitors Chem. Biol. 12 2005 621 637
-
(2005)
Chem. Biol.
, vol.12
, pp. 621-637
-
-
Knight, Z.A.1
Shokat, K.M.2
-
42
-
-
0033970020
-
Folding and binding cascades: Dynamic landscapes and population shifts
-
S. Kumar, B. Ma, C.J. Tsai, N. Sinha, and R. Nussinov Folding and binding cascades: dynamic landscapes and population shifts Protein Sci. 9 2000 10 19
-
(2000)
Protein Sci.
, vol.9
, pp. 10-19
-
-
Kumar, S.1
Ma, B.2
Tsai, C.J.3
Sinha, N.4
Nussinov, R.5
-
43
-
-
37249067732
-
The origin of protein interactions and allostery in colocalization
-
J. Kuriyan, and D. Eisenberg The origin of protein interactions and allostery in colocalization Nature 450 2007 983 990
-
(2007)
Nature
, vol.450
, pp. 983-990
-
-
Kuriyan, J.1
Eisenberg, D.2
-
44
-
-
56649083534
-
Dual roles of Nrf2 in cancer
-
A. Lau, N.F. Villeneuve, Z. Sun, P.K. Wong, and D.D. Zhang Dual roles of Nrf2 in cancer Pharmacol. Res. 58 2008 262 270
-
(2008)
Pharmacol. Res.
, vol.58
, pp. 262-270
-
-
Lau, A.1
Villeneuve, N.F.2
Sun, Z.3
Wong, P.K.4
Zhang, D.D.5
-
46
-
-
54249105941
-
Surface sites for engineering allosteric control in proteins
-
J. Lee, M. Natarajan, V.C. Nashine, M. Socolich, T. Vo, W.P. Russ, S.J. Benkovic, and R. Ranganathan Surface sites for engineering allosteric control in proteins Science 322 2008 438 442
-
(2008)
Science
, vol.322
, pp. 438-442
-
-
Lee, J.1
Natarajan, M.2
Nashine, V.C.3
Socolich, M.4
Vo, T.5
Russ, W.P.6
Benkovic, S.J.7
Ranganathan, R.8
-
48
-
-
80051646969
-
Phosphorylation barcoding as a mechanism of directing GPCR signaling
-
S.B. Liggett Phosphorylation barcoding as a mechanism of directing GPCR signaling Sci. Signal. 4 2011 pe36
-
(2011)
Sci. Signal.
, vol.4
, pp. 36
-
-
Liggett, S.B.1
-
49
-
-
70449808104
-
On the accuracy of inferring energetic coupling between distant sites in protein families from evolutionary imprints: Illustrations using lattice model
-
Z. Liu, J. Chen, and D. Thirumalai On the accuracy of inferring energetic coupling between distant sites in protein families from evolutionary imprints: illustrations using lattice model Proteins 77 2009 823 831
-
(2009)
Proteins
, vol.77
, pp. 823-831
-
-
Liu, Z.1
Chen, J.2
Thirumalai, D.3
-
51
-
-
79960189344
-
Dynamic allostery: Linkers are not merely flexible
-
B. Ma, C.-J. Tsai, T. Haliloǧlu, and R. Nussinov Dynamic allostery: linkers are not merely flexible Structure 19 2011 907 917
-
(2011)
Structure
, vol.19
, pp. 907-917
-
-
Ma, B.1
Tsai, C.-J.2
Haliloǧlu, T.3
Nussinov, R.4
-
52
-
-
80053129150
-
Allostery in pharmacology: Thermodynamics, evolution and design
-
G. Maksay Allostery in pharmacology: thermodynamics, evolution and design Prog. Biophys. Mol. Biol. 106 2011 463 473
-
(2011)
Prog. Biophys. Mol. Biol.
, vol.106
, pp. 463-473
-
-
Maksay, G.1
-
53
-
-
65349143130
-
Molecular basis for the pH dependent structural transition of Nitrophorin 4
-
M.A. Martí, D.A. Estrin, and A.E. Roitberg Molecular basis for the pH dependent structural transition of Nitrophorin 4 J. Phys. Chem. B 113 2009 2135 2142
-
(2009)
J. Phys. Chem. B
, vol.113
, pp. 2135-2142
-
-
Martí, M.A.1
Estrin, D.A.2
Roitberg, A.E.3
-
54
-
-
79551646862
-
NRF2, cancer and calorie restriction
-
A. Martín-Montalvo, J.M. Villalba, P. Navas, and R. de Cabo NRF2, cancer and calorie restriction Oncogene 30 2011 505 520
-
(2011)
Oncogene
, vol.30
, pp. 505-520
-
-
Martín-Montalvo, A.1
Villalba, J.M.2
Navas, P.3
De Cabo, R.4
-
55
-
-
38649136184
-
Allosteric cooperativity in protein kinase A
-
L.R. Masterson, A. Mascioni, N.J. Traaseth, S.S. Taylor, and G. Veglia Allosteric cooperativity in protein kinase A Proc. Natl. Acad. Sci. USA 105 2008 506 511
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 506-511
-
-
Masterson, L.R.1
Mascioni, A.2
Traaseth, N.J.3
Taylor, S.S.4
Veglia, G.5
-
56
-
-
79959900015
-
Combination of PI3K/mTOR inhibitors: Antitumor activity and molecular correlates
-
M. Mazzoletti, F. Bortolin, L. Brunelli, R. Pastorelli, S. Di Giandomenico, E. Erba, P. Ubezio, and M. Broggini Combination of PI3K/mTOR inhibitors: antitumor activity and molecular correlates Cancer Res. 71 2011 4573 4584
-
(2011)
Cancer Res.
, vol.71
, pp. 4573-4584
-
-
Mazzoletti, M.1
Bortolin, F.2
Brunelli, L.3
Pastorelli, R.4
Di Giandomenico, S.5
Erba, E.6
Ubezio, P.7
Broggini, M.8
-
57
-
-
84856323402
-
Tyrosine kinase gene fusions in cancer: Translating mechanisms into targeted therapies
-
S. Medves, and J.B. Demoulin Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies J. Cell. Mol. Med. 16 2012 237 248
-
(2012)
J. Cell. Mol. Med.
, vol.16
, pp. 237-248
-
-
Medves, S.1
Demoulin, J.B.2
-
58
-
-
38149133051
-
Transcription factories are nuclear subcompartments that remain in the absence of transcription
-
J.A. Mitchell, and P. Fraser Transcription factories are nuclear subcompartments that remain in the absence of transcription Genes Dev. 22 2008 20 25
-
(2008)
Genes Dev.
, vol.22
, pp. 20-25
-
-
Mitchell, J.A.1
Fraser, P.2
-
59
-
-
78651189765
-
On the nature of allosteric transitions: A plausible model
-
J. Monod, J. Wyman, and J.P. Changeux On the nature of allosteric transitions: a plausible model J. Mol. Biol. 12 1965 88 118
-
(1965)
J. Mol. Biol.
, vol.12
, pp. 88-118
-
-
Monod, J.1
Wyman, J.2
Changeux, J.P.3
-
60
-
-
84856098531
-
Oxysterols are allosteric activators of the oncoprotein Smoothened
-
S. Nachtergaele, L.K. Mydock, K. Krishnan, J. Rammohan, P.H. Schlesinger, D.F. Covey, and R. Rohatgi Oxysterols are allosteric activators of the oncoprotein Smoothened Nat. Chem. Biol. 8 2012 211 220
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 211-220
-
-
Nachtergaele, S.1
Mydock, L.K.2
Krishnan, K.3
Rammohan, J.4
Schlesinger, P.H.5
Covey, D.F.6
Rohatgi, R.7
-
61
-
-
4444353636
-
Regulation of protein kinases; Controlling activity through activation segment conformation
-
B. Nolen, S. Taylor, and G. Ghosh Regulation of protein kinases; controlling activity through activation segment conformation Mol. Cell 15 2004 661 675
-
(2004)
Mol. Cell
, vol.15
, pp. 661-675
-
-
Nolen, B.1
Taylor, S.2
Ghosh, G.3
-
62
-
-
84858171456
-
Allosteric modulators can restore function in an amino acid neurotransmitter receptor by slightly altering intra-molecular communication pathways
-
R. Nussinov Allosteric modulators can restore function in an amino acid neurotransmitter receptor by slightly altering intra-molecular communication pathways Br. J. Pharmacol. 165 2012 2110 2112
-
(2012)
Br. J. Pharmacol.
, vol.165
, pp. 2110-2112
-
-
Nussinov, R.1
-
63
-
-
81755184126
-
Allo-network drugs: Harnessing allostery in cellular networks
-
R. Nussinov, C.-J. Tsai, and P. Csermely Allo-network drugs: harnessing allostery in cellular networks Trends Pharmacol. Sci. 32 2011 686 693
-
(2011)
Trends Pharmacol. Sci.
, vol.32
, pp. 686-693
-
-
Nussinov, R.1
Tsai, C.-J.2
Csermely, P.3
-
65
-
-
84876275408
-
The (still) underappreciated role of allostery in the cellular network
-
10.1146/annurev-biophys-083012-130257 Published online February 28, 2013
-
R. Nussinov, C.-J. Tsai, and B. Ma The (still) underappreciated role of allostery in the cellular network Annu. Rev. Biophysics 2013 10.1146/annurev-biophys-083012-130257 Published online February 28, 2013
-
(2013)
Annu. Rev. Biophysics
-
-
Nussinov, R.1
Tsai, C.-J.2
Ma, B.3
-
66
-
-
5444243359
-
Active genes dynamically colocalize to shared sites of ongoing transcription
-
C.S. Osborne, L. Chakalova, K.E. Brown, D. Carter, A. Horton, E. Debrand, B. Goyenechea, J.A. Mitchell, S. Lopes, W. Reik, and P. Fraser Active genes dynamically colocalize to shared sites of ongoing transcription Nat. Genet. 36 2004 1065 1071
-
(2004)
Nat. Genet.
, vol.36
, pp. 1065-1071
-
-
Osborne, C.S.1
Chakalova, L.2
Brown, K.E.3
Carter, D.4
Horton, A.5
Debrand, E.6
Goyenechea, B.7
Mitchell, J.A.8
Lopes, S.9
Reik, W.10
Fraser, P.11
-
68
-
-
77952199248
-
Inhibitor-induced structural change in the HCV IRES domain IIa RNA
-
R.B. Paulsen, P.P. Seth, E.E. Swayze, R.H. Griffey, J.J. Skalicky, T.E. Cheatham 3rd, and D.R. Davis Inhibitor-induced structural change in the HCV IRES domain IIa RNA Proc. Natl. Acad. Sci. USA 107 2010 7263 7268
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 7263-7268
-
-
Paulsen, R.B.1
Seth, P.P.2
Swayze, E.E.3
Griffey, R.H.4
Skalicky, J.J.5
Cheatham III, T.E.6
Davis, D.R.7
-
69
-
-
33847718707
-
Dynamic control of signaling by modular adaptor proteins
-
T. Pawson Dynamic control of signaling by modular adaptor proteins Curr. Opin. Cell Biol. 19 2007 112 116
-
(2007)
Curr. Opin. Cell Biol.
, vol.19
, pp. 112-116
-
-
Pawson, T.1
-
70
-
-
77952046404
-
Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled
-
S.J. Pfaff, and R.J. Fletterick Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled J. Biol. Chem. 285 2010 15256 15267
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 15256-15267
-
-
Pfaff, S.J.1
Fletterick, R.J.2
-
72
-
-
84455167671
-
Hot spots for allosteric regulation on protein surfaces
-
K.A. Reynolds, R.N. McLaughlin, and R. Ranganathan Hot spots for allosteric regulation on protein surfaces Cell 147 2011 1564 1575
-
(2011)
Cell
, vol.147
, pp. 1564-1575
-
-
Reynolds, K.A.1
McLaughlin, R.N.2
Ranganathan, R.3
-
74
-
-
79955038588
-
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
-
J.D. Sadowsky, M.A. Burlingame, D.W. Wolan, C.L. McClendon, M.P. Jacobson, and J.A. Wells Turning a protein kinase on or off from a single allosteric site via disulfide trapping Proc. Natl. Acad. Sci. USA 108 2011 6056 6061
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 6056-6061
-
-
Sadowsky, J.D.1
Burlingame, M.A.2
Wolan, D.W.3
McClendon, C.L.4
Jacobson, M.P.5
Wells, J.A.6
-
75
-
-
84857432572
-
Lateral allosterism in the glucagon receptor family: Glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation
-
D. Schelshorn, F. Joly, S. Mutel, C. Hampe, B. Breton, V. Mutel, and R. Lütjens Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation Mol. Pharmacol. 81 2012 309 318
-
(2012)
Mol. Pharmacol.
, vol.81
, pp. 309-318
-
-
Schelshorn, D.1
Joly, F.2
Mutel, S.3
Hampe, C.4
Breton, B.5
Mutel, V.6
Lütjens, R.7
-
76
-
-
68349125112
-
What controls nucleosome positions?
-
E. Segal, and J. Widom What controls nucleosome positions? Trends Genet. 25 2009 335 343
-
(2009)
Trends Genet.
, vol.25
, pp. 335-343
-
-
Segal, E.1
Widom, J.2
-
77
-
-
84858175918
-
Function of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathway
-
Q. Shan, L. Han, and J.W. Lynch Function of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathway Br. J. Pharmacol. 165 2012 2113 2123
-
(2012)
Br. J. Pharmacol.
, vol.165
, pp. 2113-2123
-
-
Shan, Q.1
Han, L.2
Lynch, J.W.3
-
78
-
-
84860870716
-
Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization
-
Y. Shan, M.P. Eastwood, X. Zhang, E.T. Kim, A. Arkhipov, R.O. Dror, J. Jumper, J. Kuriyan, and D.E. Shaw Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization Cell 149 2012 860 870
-
(2012)
Cell
, vol.149
, pp. 860-870
-
-
Shan, Y.1
Eastwood, M.P.2
Zhang, X.3
Kim, E.T.4
Arkhipov, A.5
Dror, R.O.6
Jumper, J.7
Kuriyan, J.8
Shaw, D.E.9
-
79
-
-
0141706933
-
Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: Evidence for local euchromatic neighborhoods
-
L.S. Shopland, C.V. Johnson, M. Byron, J. McNeil, and J.B. Lawrence Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: evidence for local euchromatic neighborhoods J. Cell Biol. 162 2003 981 990
-
(2003)
J. Cell Biol.
, vol.162
, pp. 981-990
-
-
Shopland, L.S.1
Johnson, C.V.2
Byron, M.3
McNeil, J.4
Lawrence, J.B.5
-
81
-
-
0035853126
-
Point mutations and sequence variability in proteins: Redistributions of preexisting populations
-
N. Sinha, and R. Nussinov Point mutations and sequence variability in proteins: redistributions of preexisting populations Proc. Natl. Acad. Sci. USA 98 2001 3139 3144
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3139-3144
-
-
Sinha, N.1
Nussinov, R.2
-
82
-
-
78650147139
-
Allostery at G protein-coupled receptor homo- and heteromers: Uncharted pharmacological landscapes
-
N.J. Smith, and G. Milligan Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes Pharmacol. Rev. 62 2010 701 725
-
(2010)
Pharmacol. Rev.
, vol.62
, pp. 701-725
-
-
Smith, N.J.1
Milligan, G.2
-
84
-
-
67649766870
-
Transcription factories: Gene expression in unions?
-
H. Sutherland, and W.A. Bickmore Transcription factories: gene expression in unions? Nat. Rev. Genet. 10 2009 457 466
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 457-466
-
-
Sutherland, H.1
Bickmore, W.A.2
-
85
-
-
79551594605
-
Protein kinases: Evolution of dynamic regulatory proteins
-
S.S. Taylor, and A.P. Kornev Protein kinases: evolution of dynamic regulatory proteins Trends Biochem. Sci. 36 2011 65 77
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 65-77
-
-
Taylor, S.S.1
Kornev, A.P.2
-
86
-
-
29144449431
-
Dynamics of signaling by PKA
-
S.S. Taylor, C. Kim, D. Vigil, N.M. Haste, J. Yang, J. Wu, and G.S. Anand Dynamics of signaling by PKA Biochim. Biophys. Acta 1754 2005 25 37
-
(2005)
Biochim. Biophys. Acta
, vol.1754
, pp. 25-37
-
-
Taylor, S.S.1
Kim, C.2
Vigil, D.3
Haste, N.M.4
Yang, J.5
Wu, J.6
Anand, G.S.7
-
87
-
-
0033056708
-
Folding funnels, binding funnels, and protein function
-
C.J. Tsai, S. Kumar, B.Y. Ma, and R. Nussinov Folding funnels, binding funnels, and protein function Protein Sci. 8 1999 1181 1190
-
(1999)
Protein Sci.
, vol.8
, pp. 1181-1190
-
-
Tsai, C.J.1
Kumar, S.2
Ma, B.Y.3
Nussinov, R.4
-
88
-
-
0033621104
-
Folding and binding cascades: Shifts in energy landscapes
-
C.J. Tsai, B.Y. Ma, and R. Nussinov Folding and binding cascades: shifts in energy landscapes Proc. Natl. Acad. Sci. USA 96 1999 9970 9972
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9970-9972
-
-
Tsai, C.J.1
Ma, B.Y.2
Nussinov, R.3
-
89
-
-
41149104308
-
Allostery: Absence of a change in shape does not imply that allostery is not at play
-
C.J. Tsai, A. del Sol, and R. Nussinov Allostery: absence of a change in shape does not imply that allostery is not at play J. Mol. Biol. 378 2008 1 11
-
(2008)
J. Mol. Biol.
, vol.378
, pp. 1-11
-
-
Tsai, C.J.1
Del Sol, A.2
Nussinov, R.3
-
90
-
-
60649109828
-
Protein allostery, signal transmission and dynamics: A classification scheme of allosteric mechanisms
-
C.J. Tsai, A. Del Sol, and R. Nussinov Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms Mol. Biosyst. 5 2009 207 216
-
(2009)
Mol. Biosyst.
, vol.5
, pp. 207-216
-
-
Tsai, C.J.1
Del Sol, A.2
Nussinov, R.3
-
92
-
-
84859455527
-
Structure-based model of allostery predicts coupling between distant sites
-
P. Weinkam, J. Pons, and A. Sali Structure-based model of allostery predicts coupling between distant sites Proc. Natl. Acad. Sci. USA 109 2012 4875 4880
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 4875-4880
-
-
Weinkam, P.1
Pons, J.2
Sali, A.3
-
93
-
-
65649100094
-
Frameworks for understanding long-range intra-protein communication
-
M.J. Whitley, and A.L. Lee Frameworks for understanding long-range intra-protein communication Curr. Protein Pept. Sci. 10 2009 116 127
-
(2009)
Curr. Protein Pept. Sci.
, vol.10
, pp. 116-127
-
-
Whitley, M.J.1
Lee, A.L.2
-
94
-
-
79953213637
-
"molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology
-
M.R. Wood, C.R. Hopkins, J.T. Brogan, P.J. Conn, and C.W. Lindsley "Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology Biochemistry 50 2011 2403 2410
-
(2011)
Biochemistry
, vol.50
, pp. 2403-2410
-
-
Wood, M.R.1
Hopkins, C.R.2
Brogan, J.T.3
Conn, P.J.4
Lindsley, C.W.5
-
95
-
-
80052340812
-
The role of protein conformational fluctuations in allostery, function, and evolution
-
J.O. Wrabl, J. Gu, T. Liu, T.P. Schrank, S.T. Whitten, and V.J. Hilser The role of protein conformational fluctuations in allostery, function, and evolution Biophys. Chem. 159 2011 129 141
-
(2011)
Biophys. Chem.
, vol.159
, pp. 129-141
-
-
Wrabl, J.O.1
Gu, J.2
Liu, T.3
Schrank, T.P.4
Whitten, S.T.5
Hilser, V.J.6
-
96
-
-
33847406095
-
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity
-
C.-H. Yun, T.J. Boggon, Y. Li, M.S. Woo, H. Greulich, M. Meyerson, and M.J. Eck Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity Cancer Cell 11 2007 217 227
-
(2007)
Cancer Cell
, vol.11
, pp. 217-227
-
-
Yun, C.-H.1
Boggon, T.J.2
Li, Y.3
Woo, M.S.4
Greulich, H.5
Meyerson, M.6
Eck, M.J.7
-
97
-
-
75749146563
-
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
-
J.M. Zhang, F.J. Adrián, W. Jahnke, S.W. Cowan-Jacob, A.G. Li, R.E. Iacob, T. Sim, J. Powers, C. Dierks, and F.X. Sun Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors Nature 463 2010 501 506
-
(2010)
Nature
, vol.463
, pp. 501-506
-
-
Zhang, J.M.1
Adrián, F.J.2
Jahnke, W.3
Cowan-Jacob, S.W.4
Li, A.G.5
Iacob, R.E.6
Sim, T.7
Powers, J.8
Dierks, C.9
Sun, F.X.10
-
98
-
-
79951681020
-
Protein functional landscapes, dynamics, allostery: A tortuous path towards a universal theoretical framework
-
P.I. Zhuravlev, and G.A. Papoian Protein functional landscapes, dynamics, allostery: a tortuous path towards a universal theoretical framework Q. Rev. Biophys. 43 2010 295 332
-
(2010)
Q. Rev. Biophys.
, vol.43
, pp. 295-332
-
-
Zhuravlev, P.I.1
Papoian, G.A.2
-
99
-
-
67650331321
-
Controlling proteins through molecular springs
-
G. Zocchi Controlling proteins through molecular springs Annu. Rev. of Biophys. 38 2009 75 88
-
(2009)
Annu. Rev. of Biophys.
, vol.38
, pp. 75-88
-
-
Zocchi, G.1
|