Promises, Delivery, and Challenges of Inflammatory Bowel Disease Risk Gene Discovery

Clinical Gastroenterology and Hepatology

Volumn 11, Issue 1, 2013, Pages 22-26

  Brant, Steven R ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY RELATED PROTEIN 16 L1; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CELL PROTEIN; GUANOSINE TRIPHOSPHATASE; HLA ANTIGEN; IMMUNITY RELATED GTPASE M; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR ALPHA; INTERLEUKIN 10 RECEPTOR BETA; INTERLEUKIN 23 RECEPTOR; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; UNCLASSIFIED DRUG; USTEKINUMAB;

ARTICLE; AUTOIMMUNE DISEASE; BONE MARROW TRANSPLANTATION; CLINICAL TRIAL (TOPIC); CROHN DISEASE; DISEASE SEVERITY; ENTERITIS; FAMILY; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEREDITY; HUMAN; IMMUNITY; NEXT GENERATION SEQUENCING; NONHUMAN; PATHOGENESIS; PSORIASIS; RACE DIFFERENCE; RISK FACTOR; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TH17 CELL; TISSUE CULTURE; TRANSLATIONAL RESEARCH; ULCERATIVE COLITIS;

GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATORY BOWEL DISEASES; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84871005700     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2012.11.001     Document Type: Article

References (4)

1. Cho J.H., Brant S.R. Recent insights into the genetics of inflammatory bowel disease. Gastroenterology 2011, 140:1704-1712.
2. Brand S. Crohn's disease: Th1, Th17 or both?. The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut 2009, 58:1152-1167.
3. Wang M.-H., Okazaki T., Kugathasan S., et al. Contribution of higher risk genes and European admixture to Crohn's disease in African Americans. Inflamm Bowel Dis 2012 Mar 12, [Epub ahead of print].
4. Jostins L, Ripke S, Weersma RK, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature ;491:119-124.