메뉴 건너뛰기




Volumn 58, Issue 1, 2014, Pages 147-171

Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds

Author keywords

Chemoprevention; Dietary natural compounds; Nonalcoholic fatty liver disease

Indexed keywords

ADIPOCYTOKINE; CAROTENOID; CURCUMIN; FLAVONOL DERIVATIVE; OMEGA 3 FATTY ACID; POLYPHENOL; RESVERATROL; STILBENE DERIVATIVE;

EID: 84891402274     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201300522     Document Type: Review
Times cited : (87)

References (256)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo, P., Nonalcoholic fatty liver disease. N. Engl. J. Med. 2002, 346, 1221-1231.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 60149095703 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: an overview
    • Shifflet, A., Wu, G. Y., Non-alcoholic steatohepatitis: an overview. J. Formos. Med. Assoc. 2009, 108, 4-12.
    • (2009) J. Formos. Med. Assoc. , vol.108 , pp. 4-12
    • Shifflet, A.1    Wu, G.Y.2
  • 3
    • 77956639983 scopus 로고    scopus 로고
    • Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease
    • Neuschwander-Tetri, B. A., Clark, J. M., Bass, N. M., Van Natta, M. L. et al., Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease. Hepatology 2010, 52, 913-924.
    • (2010) Hepatology , vol.52 , pp. 913-924
    • Neuschwander-Tetri, B.A.1    Clark, J.M.2    Bass, N.M.3    Van Natta, M.L.4
  • 4
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon, G., Baranova, A., Younossi, Z. M., Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment. Pharmacol. Ther. 2011, 34, 274-285.
    • (2011) Aliment. Pharmacol. Ther. , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 5
    • 84880425040 scopus 로고    scopus 로고
    • Epidemiology and natural history of patients with NAFLD
    • Bhala, N., Jouness, R. I., Bugianesi, E., Epidemiology and natural history of patients with NAFLD. Curr. Pharm. Des. 2013, 19, 5169-5176.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 5169-5176
    • Bhala, N.1    Jouness, R.I.2    Bugianesi, E.3
  • 6
    • 84864390922 scopus 로고    scopus 로고
    • The epidemiology, pathogenesis and histopathology of fatty liver disease
    • Levene, A. P., Goldin, R. D., The epidemiology, pathogenesis and histopathology of fatty liver disease. Histopathology 2012, 61, 141-152.
    • (2012) Histopathology , vol.61 , pp. 141-152
    • Levene, A.P.1    Goldin, R.D.2
  • 7
    • 23444451889 scopus 로고    scopus 로고
    • Prevalence of and risk factors for fatty liver in a general population of Shanghai, China
    • Fan, J. G., Zhu, J., Li, X. J., Chen, L. et al., Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J. Hepatol. 2005, 43, 508-514.
    • (2005) J. Hepatol. , vol.43 , pp. 508-514
    • Fan, J.G.1    Zhu, J.2    Li, X.J.3    Chen, L.4
  • 8
    • 24044467100 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults
    • Jimba, S., Nakagami, T., Takahashi, M., Wakamatsu, T. et al., Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults. Diabet. Med. 2005, 22, 1141-1145.
    • (2005) Diabet. Med. , vol.22 , pp. 1141-1145
    • Jimba, S.1    Nakagami, T.2    Takahashi, M.3    Wakamatsu, T.4
  • 9
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    • Bedogni, G., Miglioli, L., Masutti, F., Tiribelli, C. et al., Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005, 42, 44-52.
    • (2005) Hepatology , vol.42 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3    Tiribelli, C.4
  • 10
    • 84870855668 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with components of metabolic syndrome according to body mass index in Korean adults
    • Kwon, Y. M., Oh, S. W., Hwang, S. S., Lee, C. et al., Association of nonalcoholic fatty liver disease with components of metabolic syndrome according to body mass index in Korean adults. Am. J. Gastroenterol. 2012, 107, 1852-1858.
    • (2012) Am. J. Gastroenterol. , vol.107 , pp. 1852-1858
    • Kwon, Y.M.1    Oh, S.W.2    Hwang, S.S.3    Lee, C.4
  • 11
    • 77952576769 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease
    • Bellentani, S., Scaglioni, F., Marino, M., Bedogni, G., Epidemiology of non-alcoholic fatty liver disease. Dig. Dis. 2010, 28, 155-161.
    • (2010) Dig. Dis. , vol.28 , pp. 155-161
    • Bellentani, S.1    Scaglioni, F.2    Marino, M.3    Bedogni, G.4
  • 12
    • 4344628555 scopus 로고    scopus 로고
    • The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    • McCullough, A. J., The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin. Liver Dis. 2004, 8, 521-533.
    • (2004) Clin. Liver Dis. , vol.8 , pp. 521-533
    • McCullough, A.J.1
  • 13
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt, M., Franzen, L. E., Mathiesen, U. L., Thorelius, L. et al., Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006, 44, 865-873.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3    Thorelius, L.4
  • 14
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two "hits"?
    • Day, C. P., James, O. F., Steatohepatitis: a tale of two "hits"? Gastroenterology 1998, 114, 842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 15
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis
    • Tilg, H., Moschen, A. R., Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 2010, 52, 1836-1846.
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 16
    • 2342430250 scopus 로고    scopus 로고
    • Obesity, insulin resistance, and cardiovascular disease
    • Reaven, G., Abbasi, F., McLaughlin, T., Obesity, insulin resistance, and cardiovascular disease. Recent Prog. Horm. Res. 2004, 59, 207-223.
    • (2004) Recent Prog. Horm. Res. , vol.59 , pp. 207-223
    • Reaven, G.1    Abbasi, F.2    McLaughlin, T.3
  • 17
    • 16244368502 scopus 로고    scopus 로고
    • Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients
    • Ong, J. P., Elariny, H., Collantes, R., Younoszai, A. et al., Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients. Obes. Surg. 2005, 15, 310-315.
    • (2005) Obes. Surg. , vol.15 , pp. 310-315
    • Ong, J.P.1    Elariny, H.2    Collantes, R.3    Younoszai, A.4
  • 18
    • 24744437499 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease in young adult severely obese non-diabetic patients in South Italy
    • Colicchio, P., Tarantino, G., del, G. F., Sorrentino, P. et al., Non-alcoholic fatty liver disease in young adult severely obese non-diabetic patients in South Italy. Ann. Nutr. Metab. 2005, 49, 289-295.
    • (2005) Ann. Nutr. Metab. , vol.49 , pp. 289-295
    • Colicchio, P.1    Tarantino, G.2    del, G.F.3    Sorrentino, P.4
  • 19
    • 46949091221 scopus 로고    scopus 로고
    • Fatty liver disease: predictors of nonalcoholic steatohepatitis and gallbladder disease in morbid obesity
    • Liew, P. L., Lee, W. J., Wang, W., Lee, Y. C. et al., Fatty liver disease: predictors of nonalcoholic steatohepatitis and gallbladder disease in morbid obesity. Obes. Surg. 2008, 18, 847-853.
    • (2008) Obes. Surg. , vol.18 , pp. 847-853
    • Liew, P.L.1    Lee, W.J.2    Wang, W.3    Lee, Y.C.4
  • 20
    • 39749173966 scopus 로고    scopus 로고
    • Metabolic syndrome is related to nonalcoholic steatohepatitis in severely obese subjects
    • Huang, H. L., Lin, W. Y., Lee, L. T., Wang, H. H. et al., Metabolic syndrome is related to nonalcoholic steatohepatitis in severely obese subjects. Obes. Surg. 2007, 17, 1457-1463.
    • (2007) Obes. Surg. , vol.17 , pp. 1457-1463
    • Huang, H.L.1    Lin, W.Y.2    Lee, L.T.3    Wang, H.H.4
  • 21
    • 67349271289 scopus 로고    scopus 로고
    • Does liver appearance predict histopathologic findings: prospective analysis of routine liver biopsies during bariatric surgery
    • Dolce, C. J., Russo, M., Keller, J. E., Buckingham, J. et al., Does liver appearance predict histopathologic findings: prospective analysis of routine liver biopsies during bariatric surgery. Surg. Obes. Relat. Dis. 2009, 5, 323-328.
    • (2009) Surg. Obes. Relat. Dis. , vol.5 , pp. 323-328
    • Dolce, C.J.1    Russo, M.2    Keller, J.E.3    Buckingham, J.4
  • 22
    • 33644535823 scopus 로고    scopus 로고
    • Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery
    • Harnois, F., Msika, S., Sabate, J. M., Mechler, C. et al., Prevalence and predictive factors of non-alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery. Obes. Surg. 2006, 16, 183-188.
    • (2006) Obes. Surg. , vol.16 , pp. 183-188
    • Harnois, F.1    Msika, S.2    Sabate, J.M.3    Mechler, C.4
  • 24
    • 48949085350 scopus 로고    scopus 로고
    • Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children
    • Yoo, J., Lee, S., Kim, K., Yoo, S. et al., Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children. Diabetes Res. Clin. Pract. 2008, 81, 321-326.
    • (2008) Diabetes Res. Clin. Pract. , vol.81 , pp. 321-326
    • Yoo, J.1    Lee, S.2    Kim, K.3    Yoo, S.4
  • 25
    • 77956339546 scopus 로고    scopus 로고
    • Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease
    • Patton, H. M., Yates, K., Unalp-Arida, A., Behling, C. A. et al., Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease. Am. J. Gastroenterol. 2010, 105, 2093-2102.
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 2093-2102
    • Patton, H.M.1    Yates, K.2    Unalp-Arida, A.3    Behling, C.A.4
  • 27
    • 77957832253 scopus 로고    scopus 로고
    • Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway
    • Choi, S. M., Tucker, D. F., Gross, D. N., Easton, R. M. et al., Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Mol. Cell Biol. 2010, 30, 5009-5020.
    • (2010) Mol. Cell Biol. , vol.30 , pp. 5009-5020
    • Choi, S.M.1    Tucker, D.F.2    Gross, D.N.3    Easton, R.M.4
  • 28
    • 0024307638 scopus 로고
    • Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity
    • Stralfors, P., Honnor, R. C., Insulin-induced dephosphorylation of hormone-sensitive lipase. Correlation with lipolysis and cAMP-dependent protein kinase activity. Eur. J. Biochem. 1989, 182, 379-385.
    • (1989) Eur. J. Biochem. , vol.182 , pp. 379-385
    • Stralfors, P.1    Honnor, R.C.2
  • 29
    • 0036785633 scopus 로고    scopus 로고
    • Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta
    • Lam, T. K., Yoshii, H., Haber, C. A., Bogdanovic, E. et al., Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. Am. J. Physiol. Endocrinol. Metab. 2002, 283, E682-E691.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283
    • Lam, T.K.1    Yoshii, H.2    Haber, C.A.3    Bogdanovic, E.4
  • 30
    • 0036293648 scopus 로고    scopus 로고
    • FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis
    • Boden, G., Cheung, P., Stein, T. P., Kresge, K. et al., FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am. J. Physiol. Endocrinol. Metab. 2002, 283, E12-E19.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283
    • Boden, G.1    Cheung, P.2    Stein, T.P.3    Kresge, K.4
  • 31
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden, G., Chen, X., Ruiz, J., White, J. V. et al., Mechanisms of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 1994, 93, 2438-2446.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4
  • 32
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J. et al., Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 2005, 115, 1343-1351.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4
  • 33
    • 0028091785 scopus 로고
    • Regional adiposity and morbidity
    • Kissebah, A. H., Krakower, G. R., Regional adiposity and morbidity. Physiol. Rev. 1994, 74, 761-811.
    • (1994) Physiol. Rev. , vol.74 , pp. 761-811
    • Kissebah, A.H.1    Krakower, G.R.2
  • 34
    • 0027169901 scopus 로고
    • Abdominal diameters as indicators of visceral fat: comparison between magnetic resonance imaging and anthropometry
    • van der, K. K., Leenen, R., Seidell, J. C., Deurenberg, P. et al., Abdominal diameters as indicators of visceral fat: comparison between magnetic resonance imaging and anthropometry. Br. J. Nutr. 1993, 70, 47-58.
    • (1993) Br. J. Nutr. , vol.70 , pp. 47-58
    • van der, K.K.1    Leenen, R.2    Seidell, J.C.3    Deurenberg, P.4
  • 36
    • 49649096375 scopus 로고    scopus 로고
    • Visceral fat: a key mediator of steatohepatitis in metabolic liver disease
    • van der, P. D., Milner, K. L., Hui, J., Hodge, A. et al., Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 2008, 48, 449-457.
    • (2008) Hepatology , vol.48 , pp. 449-457
    • van der, P.D.1    Milner, K.L.2    Hui, J.3    Hodge, A.4
  • 37
    • 74049159942 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: structural and functional differences
    • Ibrahim, M. M., Subcutaneous and visceral adipose tissue: structural and functional differences. Obes. Rev. 2010, 11, 11-18.
    • (2010) Obes. Rev. , vol.11 , pp. 11-18
    • Ibrahim, M.M.1
  • 38
    • 78049308422 scopus 로고    scopus 로고
    • Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study
    • Preis, S. R., Massaro, J. M., Robins, S. J., Hoffmann, U. et al., Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study. Obesity (Silver Spring) 2010, 18, 2191-2198.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 2191-2198
    • Preis, S.R.1    Massaro, J.M.2    Robins, S.J.3    Hoffmann, U.4
  • 39
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme, A., Virbasius, J. V., Puri, V., Czech, M. P., Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat. Rev. Mol. Cell Biol. 2008, 9, 367-377.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 40
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil, G. S., Shargill, N. S., Spiegelman, B. M., Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259, 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 41
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal, K. T., Wiesbrock, S. M., Marino, M. W., Hotamisligil, G. S., Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389, 610-614.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 42
    • 33646161443 scopus 로고    scopus 로고
    • Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2
    • Haukeland, J. W., Damas, J. K., Konopski, Z., Loberg, E. M. et al., Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. J. Hepatol. 2006, 44, 1167-1174.
    • (2006) J. Hepatol. , vol.44 , pp. 1167-1174
    • Haukeland, J.W.1    Damas, J.K.2    Konopski, Z.3    Loberg, E.M.4
  • 43
    • 3042744737 scopus 로고    scopus 로고
    • Beyond insulin resistance in NASH: TNF-alpha or adiponectin?
    • Hui, J. M., Hodge, A., Farrell, G. C., Kench, J. G. et al., Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 2004, 40, 46-54.
    • (2004) Hepatology , vol.40 , pp. 46-54
    • Hui, J.M.1    Hodge, A.2    Farrell, G.C.3    Kench, J.G.4
  • 44
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Crespo, J., Cayon, A., Fernandez-Gil, P., Hernandez-Guerra, M. et al., Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 2001, 34, 1158-1163.
    • (2001) Hepatology , vol.34 , pp. 1158-1163
    • Crespo, J.1    Cayon, A.2    Fernandez-Gil, P.3    Hernandez-Guerra, M.4
  • 45
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li, Z., Yang, S., Lin, H., Huang, J. et al., Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003, 37, 343-350.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3    Huang, J.4
  • 46
    • 79959446947 scopus 로고    scopus 로고
    • Pentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial
    • Van Wagner, L. B., Koppe, S. W., Brunt, E. M., Gottstein, J. et al., Pentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial. Ann. Hepatol. 2011, 10, 277-286.
    • (2011) Ann. Hepatol. , vol.10 , pp. 277-286
    • Van Wagner, L.B.1    Koppe, S.W.2    Brunt, E.M.3    Gottstein, J.4
  • 47
    • 34547843608 scopus 로고    scopus 로고
    • Amelioration of steatohepatitis with pentoxifylline in a novel nonalcoholic steatohepatitis model induced by high-fat diet
    • Yalniz, M., Bahcecioglu, I. H., Kuzu, N., Celebi, S. et al., Amelioration of steatohepatitis with pentoxifylline in a novel nonalcoholic steatohepatitis model induced by high-fat diet. Dig. Dis. Sci. 2007, 52, 2380-2386.
    • (2007) Dig. Dis. Sci. , vol.52 , pp. 2380-2386
    • Yalniz, M.1    Bahcecioglu, I.H.2    Kuzu, N.3    Celebi, S.4
  • 48
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein, A. E., Werneburg, N. W., Canbay, A., Guicciardi, M. E. et al., Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004, 40, 185-194.
    • (2004) Hepatology , vol.40 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3    Guicciardi, M.E.4
  • 49
    • 33646197298 scopus 로고    scopus 로고
    • Biochemical and molecular basis of insulin resistance
    • Chakraborty, C., Biochemical and molecular basis of insulin resistance. Curr. Protein Pept. Sci. 2006, 7, 113-121.
    • (2006) Curr. Protein Pept. Sci. , vol.7 , pp. 113-121
    • Chakraborty, C.1
  • 50
    • 0025282841 scopus 로고
    • The effect of diet on tumor necrosis factor stimulation of hepatic lipogenesis
    • Feingold, K. R., Soued, M., Serio, M. K., Adi, S. et al., The effect of diet on tumor necrosis factor stimulation of hepatic lipogenesis. Metabolism 1990, 39, 623-632.
    • (1990) Metabolism , vol.39 , pp. 623-632
    • Feingold, K.R.1    Soued, M.2    Serio, M.K.3    Adi, S.4
  • 51
    • 77956114717 scopus 로고    scopus 로고
    • Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression
    • Moschen, A. R., Molnar, C., Geiger, S., Graziadei, I. et al., Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression. Gut 2010, 59, 1259-1264.
    • (2010) Gut , vol.59 , pp. 1259-1264
    • Moschen, A.R.1    Molnar, C.2    Geiger, S.3    Graziadei, I.4
  • 52
    • 0035049305 scopus 로고    scopus 로고
    • Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women
    • Fernandez-Real, J. M., Vayreda, M., Richart, C., Gutierrez, C. et al., Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J. Clin. Endocrinol. Metab. 2001, 86, 1154-1159.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 1154-1159
    • Fernandez-Real, J.M.1    Vayreda, M.2    Richart, C.3    Gutierrez, C.4
  • 53
    • 84872023970 scopus 로고    scopus 로고
    • Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis
    • Wang, X., Bao, W., Liu, J., Ouyang, Y. Y. et al., Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 2013, 36, 166-175.
    • (2013) Diabetes Care , vol.36 , pp. 166-175
    • Wang, X.1    Bao, W.2    Liu, J.3    Ouyang, Y.Y.4
  • 54
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • Fontana, L., Eagon, J. C., Trujillo, M. E., Scherer, P. E. et al., Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007, 56, 1010-1013.
    • (2007) Diabetes , vol.56 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4
  • 55
    • 0037853260 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    • Senn, J. J., Klover, P. J., Nowak, I. A., Zimmers, T. A. et al., Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J. Biol. Chem. 2003, 278, 13740-13746.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13740-13746
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Zimmers, T.A.4
  • 56
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • Sabio, G., Das, M., Mora, A., Zhang, Z. et al., A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008, 322, 1539-1543.
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1    Das, M.2    Mora, A.3    Zhang, Z.4
  • 57
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman, J. M., Halaas, J. L., Leptin and the regulation of body weight in mammals. Nature 1998, 395, 763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 58
    • 34249697436 scopus 로고    scopus 로고
    • Role of leptin in immunity
    • Lam, Q. L., Lu, L., Role of leptin in immunity. Cell. Mol. Immunol. 2007, 4, 1-13.
    • (2007) Cell. Mol. Immunol. , vol.4 , pp. 1-13
    • Lam, Q.L.1    Lu, L.2
  • 59
    • 48049105312 scopus 로고    scopus 로고
    • Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease
    • Huang, X. D., Fan, Y., Zhang, H., Wang, P. et al., Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. World J. Gastroenterol. 2008, 14, 2888-2893.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 2888-2893
    • Huang, X.D.1    Fan, Y.2    Zhang, H.3    Wang, P.4
  • 60
    • 70449730945 scopus 로고    scopus 로고
    • Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease
    • Lemoine, M., Ratziu, V., Kim, M., Maachi, M. et al., Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease. Liver Int. 2009, 29, 1431-1438.
    • (2009) Liver Int. , vol.29 , pp. 1431-1438
    • Lemoine, M.1    Ratziu, V.2    Kim, M.3    Maachi, M.4
  • 61
    • 0036329894 scopus 로고    scopus 로고
    • Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?
    • Chitturi, S., Farrell, G., Frost, L., Kriketos, A. et al., Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology 2002, 36, 403-409.
    • (2002) Hepatology , vol.36 , pp. 403-409
    • Chitturi, S.1    Farrell, G.2    Frost, L.3    Kriketos, A.4
  • 62
    • 48049105312 scopus 로고    scopus 로고
    • Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease
    • Huang, X. D., Fan, Y., Zhang, H., Wang, P. et al., Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. World J. Gastroenterol. 2008, 14, 2888-2893.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 2888-2893
    • Huang, X.D.1    Fan, Y.2    Zhang, H.3    Wang, P.4
  • 63
    • 50849141717 scopus 로고    scopus 로고
    • Leptin in nonalcoholic fatty liver disease
    • Canbakan, B., Tahan, V., Balci, H., Hatemi, I. et al., Leptin in nonalcoholic fatty liver disease. Ann. Hepatol. 2008, 7, 249-254.
    • (2008) Ann. Hepatol. , vol.7 , pp. 249-254
    • Canbakan, B.1    Tahan, V.2    Balci, H.3    Hatemi, I.4
  • 64
    • 0036288818 scopus 로고    scopus 로고
    • Leptin, liver, and obese mice-fibrosis in the fat lane
    • Anania, F. A., Leptin, liver, and obese mice-fibrosis in the fat lane. Hepatology 2002, 36, 246-248.
    • (2002) Hepatology , vol.36 , pp. 246-248
    • Anania, F.A.1
  • 65
    • 0036234147 scopus 로고    scopus 로고
    • Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
    • Ikejima, K., Takei, Y., Honda, H., Hirose, M. et al., Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002, 122, 1399-1410.
    • (2002) Gastroenterology , vol.122 , pp. 1399-1410
    • Ikejima, K.1    Takei, Y.2    Honda, H.3    Hirose, M.4
  • 66
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • Leclercq, I. A., Farrell, G. C., Schriemer, R., Robertson, G. R., Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J. Hepatol. 2002, 37, 206-213.
    • (2002) J. Hepatol. , vol.37 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 67
    • 67650963803 scopus 로고    scopus 로고
    • Kupffer cells mediate leptin-induced liver fibrosis
    • Wang, J., Leclercq, I., Brymora, J. M., Xu, N. et al., Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology 2009, 137, 713-723.
    • (2009) Gastroenterology , vol.137 , pp. 713-723
    • Wang, J.1    Leclercq, I.2    Brymora, J.M.3    Xu, N.4
  • 68
    • 10844246291 scopus 로고    scopus 로고
    • Decreased plasma adiponectin concentrations are closely associated with nonalcoholic hepatic steatosis in obese individuals
    • Targher, G., Bertolini, L., Scala, L., Poli, F. et al., Decreased plasma adiponectin concentrations are closely associated with nonalcoholic hepatic steatosis in obese individuals. Clin. Endocrinol. (Oxf.) 2004, 61, 700-703.
    • (2004) Clin. Endocrinol. (Oxf.) , vol.61 , pp. 700-703
    • Targher, G.1    Bertolini, L.2    Scala, L.3    Poli, F.4
  • 69
    • 28844440050 scopus 로고    scopus 로고
    • Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease
    • Louthan, M. V., Barve, S., McClain, C. J., Joshi-Barve, S., Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease. J. Pediatr. 2005, 147, 835-838.
    • (2005) J. Pediatr. , vol.147 , pp. 835-838
    • Louthan, M.V.1    Barve, S.2    McClain, C.J.3    Joshi-Barve, S.4
  • 70
    • 79959672175 scopus 로고    scopus 로고
    • Adiponectin, a key adipokine in obesity related liver diseases
    • Buechler, C., Wanninger, J., Neumeier, M., Adiponectin, a key adipokine in obesity related liver diseases. World J. Gastroenterol. 2011, 17, 2801-2811.
    • (2011) World J. Gastroenterol. , vol.17 , pp. 2801-2811
    • Buechler, C.1    Wanninger, J.2    Neumeier, M.3
  • 71
    • 77952565420 scopus 로고    scopus 로고
    • The role of cytokines in non-alcoholic fatty liver disease
    • Tilg, H., The role of cytokines in non-alcoholic fatty liver disease. Dig. Dis. 2010, 28, 179-185.
    • (2010) Dig. Dis. , vol.28 , pp. 179-185
    • Tilg, H.1
  • 72
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu, A., Wang, Y., Keshaw, H., Xu, L. Y. et al., The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 2003, 112, 91-100.
    • (2003) J. Clin. Invest. , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4
  • 73
    • 63149189738 scopus 로고    scopus 로고
    • Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
    • Awazawa, M., Ueki, K., Inabe, K., Yamauchi, T. et al., Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. Biochem. Biophys. Res. Commun. 2009, 382, 51-56.
    • (2009) Biochem. Biophys. Res. Commun. , vol.382 , pp. 51-56
    • Awazawa, M.1    Ueki, K.2    Inabe, K.3    Yamauchi, T.4
  • 74
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A. R., Kahn, C. R., Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414, 799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 75
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: insights into insulin action
    • Taniguchi, C. M., Emanuelli, B., Kahn, C. R., Critical nodes in signalling pathways: insights into insulin action. Nat. Rev. Mol. Cell Biol. 2006, 7, 85-96.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 76
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    • Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J. et al., Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003, 423, 550-555.
    • (2003) Nature , vol.423 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3    Walkey, C.J.4
  • 77
    • 0035912228 scopus 로고    scopus 로고
    • Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10
    • Chiang, S. H., Baumann, C. A., Kanzaki, M., Thurmond, D. C. et al., Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature 2001, 410, 944-948.
    • (2001) Nature , vol.410 , pp. 944-948
    • Chiang, S.H.1    Baumann, C.A.2    Kanzaki, M.3    Thurmond, D.C.4
  • 78
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    • Postic, C., Girard, J., Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J. Clin. Invest. 2008, 118, 829-838.
    • (2008) J. Clin. Invest. , vol.118 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 79
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn, S. E., The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003, 46, 3-19.
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 80
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P. et al., Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004, 40, 1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4
  • 81
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
    • Targher, G., Bertolini, L., Padovani, R., Rodella, S. et al., Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 2007, 30, 1212-1218.
    • (2007) Diabetes Care , vol.30 , pp. 1212-1218
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4
  • 82
    • 77955463534 scopus 로고    scopus 로고
    • Newly diagnosed diabetes mellitus as a risk factor for serious liver disease
    • Porepa, L., Ray, J. G., Sanchez-Romeu, P., Booth, G. L., Newly diagnosed diabetes mellitus as a risk factor for serious liver disease. Can. Med. Assoc. J. 2010, 182, E526-E531.
    • (2010) Can. Med. Assoc. J. , vol.182
    • Porepa, L.1    Ray, J.G.2    Sanchez-Romeu, P.3    Booth, G.L.4
  • 83
    • 68949129467 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus
    • Prashanth, M., Ganesh, H. K., Vima, M. V., John, M. et al., Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. J. Assoc. Physicians India 2009, 57, 205-210.
    • (2009) J. Assoc. Physicians India , vol.57 , pp. 205-210
    • Prashanth, M.1    Ganesh, H.K.2    Vima, M.V.3    John, M.4
  • 84
    • 77954424925 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort study
    • Adams, L. A., Harmsen, S., St Sauver, J. L., Charatcharoenwitthaya, P. et al., Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort study. Am. J. Gastroenterol. 2010, 105, 1567-1573.
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 1567-1573
    • Adams, L.A.1    Harmsen, S.2    St Sauver, J.L.3    Charatcharoenwitthaya, P.4
  • 85
    • 0041314066 scopus 로고    scopus 로고
    • Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice
    • Voshol, P. J., Haemmerle, G., Ouwens, D. M., Zimmermann, R. et al., Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 2003, 144, 3456-3462.
    • (2003) Endocrinology , vol.144 , pp. 3456-3462
    • Voshol, P.J.1    Haemmerle, G.2    Ouwens, D.M.3    Zimmermann, R.4
  • 86
    • 79960847840 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment
    • Smith, B. W., Adams, L. A., Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment. Nat. Rev. Endocrinol. 2011, 7, 456-465.
    • (2011) Nat. Rev. Endocrinol. , vol.7 , pp. 456-465
    • Smith, B.W.1    Adams, L.A.2
  • 87
    • 80053910309 scopus 로고    scopus 로고
    • JNKs, insulin resistance and inflammation: a possible link between NAFLD and coronary artery disease
    • Tarantino, G., Caputi, A., JNKs, insulin resistance and inflammation: a possible link between NAFLD and coronary artery disease. World J. Gastroenterol. 2011, 17, 3785-3794.
    • (2011) World J. Gastroenterol. , vol.17 , pp. 3785-3794
    • Tarantino, G.1    Caputi, A.2
  • 88
    • 0037216466 scopus 로고    scopus 로고
    • Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets
    • Schwarz, J. M., Linfoot, P., Dare, D., Aghajanian, K., Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am. J. Clin. Nutr. 2003, 77, 43-50.
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 43-50
    • Schwarz, J.M.1    Linfoot, P.2    Dare, D.3    Aghajanian, K.4
  • 89
    • 0035970805 scopus 로고    scopus 로고
    • Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
    • bu-Elheiga, L., Matzuk, M. M., bo-Hashema, K. A., Wakil, S. J., Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 2001, 291, 2613-2616.
    • (2001) Science , vol.291 , pp. 2613-2616
    • bu-Elheiga, L.1    Matzuk, M.M.2    bo-Hashema, K.A.3    Wakil, S.J.4
  • 90
    • 2342509057 scopus 로고    scopus 로고
    • Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
    • An, J., Muoio, D. M., Shiota, M., Fujimoto, Y. et al., Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat. Med. 2004, 10, 268-274.
    • (2004) Nat. Med. , vol.10 , pp. 268-274
    • An, J.1    Muoio, D.M.2    Shiota, M.3    Fujimoto, Y.4
  • 91
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M. et al., Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003, 125, 437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4
  • 93
    • 43949108922 scopus 로고    scopus 로고
    • The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity
    • Li, Z., Berk, M., McIntyre, T. M., Gores, G. J. et al., The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology 2008, 47, 1495-1503.
    • (2008) Hepatology , vol.47 , pp. 1495-1503
    • Li, Z.1    Berk, M.2    McIntyre, T.M.3    Gores, G.J.4
  • 94
    • 65549136260 scopus 로고    scopus 로고
    • Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase
    • Li, Z. Z., Berk, M., McIntyre, T. M., Feldstein, A. E., Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J. Biol. Chem. 2009, 284, 5637-5644.
    • (2009) J. Biol. Chem. , vol.284 , pp. 5637-5644
    • Li, Z.Z.1    Berk, M.2    McIntyre, T.M.3    Feldstein, A.E.4
  • 95
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi, H., Bronk, S. F., Werneburg, N. W., Gores, G. J., Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 2006, 281, 12093-12101.
    • (2006) J. Biol. Chem. , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3    Gores, G.J.4
  • 96
    • 34848861130 scopus 로고    scopus 로고
    • Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis
    • Barreyro, F. J., Kobayashi, S., Bronk, S. F., Werneburg, N. W. et al., Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J. Biol. Chem. 2007, 282, 27141-27154.
    • (2007) J. Biol. Chem. , vol.282 , pp. 27141-27154
    • Barreyro, F.J.1    Kobayashi, S.2    Bronk, S.F.3    Werneburg, N.W.4
  • 97
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M. et al., Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003, 125, 437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4
  • 98
    • 0348134733 scopus 로고    scopus 로고
    • Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
    • Feldstein, A. E., Canbay, A., Guicciardi, M. E., Higuchi, H. et al., Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J. Hepatol. 2003, 39, 978-983.
    • (2003) J. Hepatol. , vol.39 , pp. 978-983
    • Feldstein, A.E.1    Canbay, A.2    Guicciardi, M.E.3    Higuchi, H.4
  • 99
    • 34548360510 scopus 로고    scopus 로고
    • Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats
    • Inoue, Y., Asanuma, T., Smith, N., Saunders, D. et al., Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. Free Radic. Res. 2007, 41, 972-980.
    • (2007) Free Radic. Res. , vol.41 , pp. 972-980
    • Inoue, Y.1    Asanuma, T.2    Smith, N.3    Saunders, D.4
  • 100
    • 34547193134 scopus 로고    scopus 로고
    • Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
    • Malhi, H., Barreyro, F. J., Isomoto, H., Bronk, S. F. et al., Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 2007, 56, 1124-1131.
    • (2007) Gut , vol.56 , pp. 1124-1131
    • Malhi, H.1    Barreyro, F.J.2    Isomoto, H.3    Bronk, S.F.4
  • 101
    • 36348941705 scopus 로고    scopus 로고
    • Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver
    • Volkmann, X., Fischer, U., Bahr, M. J., Ott, M. et al., Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology 2007, 46, 1498-1508.
    • (2007) Hepatology , vol.46 , pp. 1498-1508
    • Volkmann, X.1    Fischer, U.2    Bahr, M.J.3    Ott, M.4
  • 102
    • 80655149472 scopus 로고    scopus 로고
    • Death receptor 5 signaling promotes hepatocyte lipoapoptosis
    • Cazanave, S. C., Mott, J. L., Bronk, S. F., Werneburg, N. W. et al., Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J. Biol. Chem. 2011, 286, 39336-39348.
    • (2011) J. Biol. Chem. , vol.286 , pp. 39336-39348
    • Cazanave, S.C.1    Mott, J.L.2    Bronk, S.F.3    Werneburg, N.W.4
  • 103
    • 33745828301 scopus 로고    scopus 로고
    • Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
    • Wei, Y., Wang, D., Topczewski, F., Pagliassotti, M. J., Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am. J. Physiol. Endocrinol. Metab. 2006, 291, E275-E281.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Wei, Y.1    Wang, D.2    Topczewski, F.3    Pagliassotti, M.J.4
  • 104
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • Wang, D., Wei, Y., Pagliassotti, M. J., Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 2006, 147, 943-951.
    • (2006) Endocrinology , vol.147 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 105
    • 38649124615 scopus 로고    scopus 로고
    • Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    • Puri, P., Mirshahi, F., Cheung, O., Natarajan, R. et al., Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008, 134, 568-576.
    • (2008) Gastroenterology , vol.134 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3    Natarajan, R.4
  • 106
    • 80055033307 scopus 로고    scopus 로고
    • Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis
    • Rinella, M. E., Siddiqui, M. S., Gardikiotes, K., Gottstein, J. et al., Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis. Hepatology 2011, 54, 1600-1609.
    • (2011) Hepatology , vol.54 , pp. 1600-1609
    • Rinella, M.E.1    Siddiqui, M.S.2    Gardikiotes, K.3    Gottstein, J.4
  • 107
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil, G. S., Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140, 900-917.
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 108
    • 29144531843 scopus 로고    scopus 로고
    • Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases
    • Seki, S., Kitada, T., Sakaguchi, H., Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases. Hepatol. Res. 2005, 33, 132-134.
    • (2005) Hepatol. Res. , vol.33 , pp. 132-134
    • Seki, S.1    Kitada, T.2    Sakaguchi, H.3
  • 109
    • 33750616470 scopus 로고    scopus 로고
    • Oxidant stress and antioxidant status among patients with nonalcoholic fatty liver disease (NAFLD)
    • Madan, K., Bhardwaj, P., Thareja, S., Gupta, S. D. et al., Oxidant stress and antioxidant status among patients with nonalcoholic fatty liver disease (NAFLD). J. Clin. Gastroenterol. 2006, 40, 930-935.
    • (2006) J. Clin. Gastroenterol. , vol.40 , pp. 930-935
    • Madan, K.1    Bhardwaj, P.2    Thareja, S.3    Gupta, S.D.4
  • 110
    • 0029829455 scopus 로고    scopus 로고
    • Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
    • Weltman, M. D., Farrell, G. C., Liddle, C., Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 1996, 111, 1645-1653.
    • (1996) Gastroenterology , vol.111 , pp. 1645-1653
    • Weltman, M.D.1    Farrell, G.C.2    Liddle, C.3
  • 111
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
    • Weltman, M. D., Farrell, G. C., Hall, P., Ingelman-Sundberg, M. et al., Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 1998, 27, 128-133.
    • (1998) Hepatology , vol.27 , pp. 128-133
    • Weltman, M.D.1    Farrell, G.C.2    Hall, P.3    Ingelman-Sundberg, M.4
  • 112
    • 0034939632 scopus 로고    scopus 로고
    • Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system
    • Reddy, J. K., Hashimoto, T., Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. Annu. Rev. Nutr. 2001, 21, 193-230.
    • (2001) Annu. Rev. Nutr. , vol.21 , pp. 193-230
    • Reddy, J.K.1    Hashimoto, T.2
  • 113
    • 0033198978 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in non-alcoholic steatohepatitis
    • Caldwell, S. H., Swerdlow, R. H., Khan, E. M., Iezzoni, J. C. et al., Mitochondrial abnormalities in non-alcoholic steatohepatitis. J. Hepatol. 1999, 31, 430-434.
    • (1999) J. Hepatol. , vol.31 , pp. 430-434
    • Caldwell, S.H.1    Swerdlow, R.H.2    Khan, E.M.3    Iezzoni, J.C.4
  • 114
    • 18144444592 scopus 로고    scopus 로고
    • Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis
    • Perez-Carreras, M., Del, H. P., Martin, M. A., Rubio, J. C. et al., Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 2003, 38, 999-1007.
    • (2003) Hepatology , vol.38 , pp. 999-1007
    • Perez-Carreras, M.1    Del, H.P.2    Martin, M.A.3    Rubio, J.C.4
  • 115
    • 0040141644 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha increases the steady-state reduction of cytochrome b of the mitochondrial respiratory chain in metabolically inhibited L929 cells
    • Sanchez-Alcazar, J. A., Schneider, E., Martinez, M. A., Carmona, P. et al., Tumor necrosis factor-alpha increases the steady-state reduction of cytochrome b of the mitochondrial respiratory chain in metabolically inhibited L929 cells. J. Biol. Chem. 2000, 275, 13353-13361.
    • (2000) J. Biol. Chem. , vol.275 , pp. 13353-13361
    • Sanchez-Alcazar, J.A.1    Schneider, E.2    Martinez, M.A.3    Carmona, P.4
  • 116
    • 0032511894 scopus 로고    scopus 로고
    • Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis
    • Higuchi, M., Proske, R. J., Yeh, E. T., Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis. Oncogene 1998, 17, 2515-2524.
    • (1998) Oncogene , vol.17 , pp. 2515-2524
    • Higuchi, M.1    Proske, R.J.2    Yeh, E.T.3
  • 117
    • 85047692761 scopus 로고    scopus 로고
    • Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
    • Pan, M., Cederbaum, A. I., Zhang, Y. L., Ginsberg, H. N. et al., Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J. Clin. Invest. 2004, 113, 1277-1287.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1277-1287
    • Pan, M.1    Cederbaum, A.I.2    Zhang, Y.L.3    Ginsberg, H.N.4
  • 118
    • 26044463449 scopus 로고    scopus 로고
    • Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease
    • Perlemuter, G., vit-Spraul, A., Cosson, C., Conti, M. et al., Increase in liver antioxidant enzyme activities in non-alcoholic fatty liver disease. Liver Int. 2005, 25, 946-953.
    • (2005) Liver Int. , vol.25 , pp. 946-953
    • Perlemuter, G.1    vit-Spraul, A.2    Cosson, C.3    Conti, M.4
  • 119
    • 0033200054 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
    • Brunt, E. M., Janney, C. G., Di Bisceglie, A. M., Neuschwander-Tetri, B. A. et al., Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am. J. Gastroenterol. 1999, 94, 2467-2474.
    • (1999) Am. J. Gastroenterol. , vol.94 , pp. 2467-2474
    • Brunt, E.M.1    Janney, C.G.2    Di Bisceglie, A.M.3    Neuschwander-Tetri, B.A.4
  • 120
    • 40949141827 scopus 로고    scopus 로고
    • Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease
    • Chalasani, N., Wilson, L., Kleiner, D. E., Cummings, O. W. et al., Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease. J. Hepatol. 2008, 48, 829-834.
    • (2008) J. Hepatol. , vol.48 , pp. 829-834
    • Chalasani, N.1    Wilson, L.2    Kleiner, D.E.3    Cummings, O.W.4
  • 121
    • 3042739914 scopus 로고    scopus 로고
    • Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes
    • Schwabe, R. F., Uchinami, H., Qian, T., Bennett, B. L. et al., Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. 2004, 18, 720-722.
    • (2004) FASEB J. , vol.18 , pp. 720-722
    • Schwabe, R.F.1    Uchinami, H.2    Qian, T.3    Bennett, B.L.4
  • 122
    • 27744458510 scopus 로고    scopus 로고
    • NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • Dela, P. A., Leclercq, I., Field, J., George, J. et al., NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 2005, 129, 1663-1674.
    • (2005) Gastroenterology , vol.129 , pp. 1663-1674
    • Dela, P.A.1    Leclercq, I.2    Field, J.3    George, J.4
  • 123
    • 33644813043 scopus 로고    scopus 로고
    • JNK1 but not JNK2 promotes the development of steatohepatitis in mice
    • Schattenberg, J. M., Singh, R., Wang, Y., Lefkowitch, J. H. et al., JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 2006, 43, 163-172.
    • (2006) Hepatology , vol.43 , pp. 163-172
    • Schattenberg, J.M.1    Singh, R.2    Wang, Y.3    Lefkowitch, J.H.4
  • 124
    • 79959573042 scopus 로고    scopus 로고
    • Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
    • Csak, T., Ganz, M., Pespisa, J., Kodys, K. et al., Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology 2011, 54, 133-144.
    • (2011) Hepatology , vol.54 , pp. 133-144
    • Csak, T.1    Ganz, M.2    Pespisa, J.3    Kodys, K.4
  • 125
    • 44949233003 scopus 로고    scopus 로고
    • Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
    • Wieckowska, A., Papouchado, B. G., Li, Z., Lopez, R. et al., Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am. J. Gastroenterol. 2008, 103, 1372-1379.
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 1372-1379
    • Wieckowska, A.1    Papouchado, B.G.2    Li, Z.3    Lopez, R.4
  • 126
    • 77955150888 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice
    • Yamaguchi, K., Itoh, Y., Yokomizo, C., Nishimura, T. et al., Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. Lab. Invest. 2010, 90, 1169-1178.
    • (2010) Lab. Invest. , vol.90 , pp. 1169-1178
    • Yamaguchi, K.1    Itoh, Y.2    Yokomizo, C.3    Nishimura, T.4
  • 127
    • 84859445823 scopus 로고    scopus 로고
    • TGF-beta in progression of liver disease
    • Dooley, S., ten, D. P., TGF-beta in progression of liver disease. Cell Tissue Res. 2012, 347, 245-256.
    • (2012) Cell Tissue Res. , vol.347 , pp. 245-256
    • Dooley, S.1    ten, D.P.2
  • 128
    • 33748440540 scopus 로고    scopus 로고
    • Physiologic concentrations of leptin increase collagen production by non-immortalized human hepatic stellate cells
    • Choudhury, J., Mirshahi, F., Murthy, K. S., Yager, D. R. et al., Physiologic concentrations of leptin increase collagen production by non-immortalized human hepatic stellate cells. Metabolism 2006, 55, 1317-1322.
    • (2006) Metabolism , vol.55 , pp. 1317-1322
    • Choudhury, J.1    Mirshahi, F.2    Murthy, K.S.3    Yager, D.R.4
  • 129
    • 0242438087 scopus 로고    scopus 로고
    • Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis
    • George, J., Pera, N., Phung, N., Leclercq, I. et al., Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis. J. Hepatol. 2003, 39, 756-764.
    • (2003) J. Hepatol. , vol.39 , pp. 756-764
    • George, J.1    Pera, N.2    Phung, N.3    Leclercq, I.4
  • 130
    • 13844297437 scopus 로고    scopus 로고
    • Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice
    • Teufelhofer, O., Parzefall, W., Kainzbauer, E., Ferk, F. et al., Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice. Carcinogenesis 2005, 26, 319-329.
    • (2005) Carcinogenesis , vol.26 , pp. 319-329
    • Teufelhofer, O.1    Parzefall, W.2    Kainzbauer, E.3    Ferk, F.4
  • 131
    • 79956336707 scopus 로고    scopus 로고
    • Transcriptional profile of genes involved in oxidative stress and antioxidant defense in a dietary murine model of steatohepatitis
    • Gornicka, A., Morris-Stiff, G., Thapaliya, S., Papouchado, B. G. et al., Transcriptional profile of genes involved in oxidative stress and antioxidant defense in a dietary murine model of steatohepatitis. Antioxid. Redox Signal. 2011, 15, 437-445.
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 437-445
    • Gornicka, A.1    Morris-Stiff, G.2    Thapaliya, S.3    Papouchado, B.G.4
  • 132
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
    • Musso, G., Cassader, M., Rosina, F., Gambino, R., Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia 2012, 55, 885-904.
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3    Gambino, R.4
  • 133
    • 84863079163 scopus 로고    scopus 로고
    • Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD)
    • Kim, M. S., Kung, S., Grewal, T., Roufogalis, B. D., Methodologies for investigating natural medicines for the treatment of nonalcoholic fatty liver disease (NAFLD). Curr. Pharm. Biotechnol. 2012, 13, 278-291.
    • (2012) Curr. Pharm. Biotechnol. , vol.13 , pp. 278-291
    • Kim, M.S.1    Kung, S.2    Grewal, T.3    Roufogalis, B.D.4
  • 134
    • 77954239704 scopus 로고    scopus 로고
    • A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    • Musso, G., Gambino, R., Cassader, M., Pagano, G., A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 2010, 52, 79-104.
    • (2010) Hepatology , vol.52 , pp. 79-104
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 135
    • 77955285732 scopus 로고    scopus 로고
    • Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality
    • Nissen, S. E., Wolski, K., Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch. Intern. Med. 2010, 170, 1191-1201.
    • (2010) Arch. Intern. Med. , vol.170 , pp. 1191-1201
    • Nissen, S.E.1    Wolski, K.2
  • 136
    • 84858175296 scopus 로고    scopus 로고
    • Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet
    • Bahcecioglu, I. H., Kuzu, N., Metin, K., Ozercan, I. H. et al., Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet. Vet. Med. Int. 2010, 2010, 1-8.
    • (2010) Vet. Med. Int. , vol.2010 , pp. 1-8
    • Bahcecioglu, I.H.1    Kuzu, N.2    Metin, K.3    Ozercan, I.H.4
  • 137
    • 77949876397 scopus 로고    scopus 로고
    • Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats
    • Wang, Y., Ausman, L. M., Greenberg, A. S., Russell, R. M. et al., Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. Int. J. Cancer 2010, 126, 1788-1796.
    • (2010) Int. J. Cancer , vol.126 , pp. 1788-1796
    • Wang, Y.1    Ausman, L.M.2    Greenberg, A.S.3    Russell, R.M.4
  • 138
    • 84874299866 scopus 로고    scopus 로고
    • Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils
    • Choi, S. K., Seo, J. S., Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils. Nutr. Res. Pract. 2013, 7, 26-33.
    • (2013) Nutr. Res. Pract. , vol.7 , pp. 26-33
    • Choi, S.K.1    Seo, J.S.2
  • 139
    • 84867931323 scopus 로고    scopus 로고
    • Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet
    • Ahn, J., Lee, H., Jung, C. H., Ha, T., Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet. Mol. Nutr. Food Res. 2012, 56, 1665-1674.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 1665-1674
    • Ahn, J.1    Lee, H.2    Jung, C.H.3    Ha, T.4
  • 140
    • 0026536942 scopus 로고
    • Beta-carotene uptake and tissue distribution in ferrets (Mustela putorius furo)
    • Gugger, E. T., Bierer, T. L., Henze, T. M., White, W. S. et al., Beta-carotene uptake and tissue distribution in ferrets (Mustela putorius furo). J. Nutr. 1992, 122, 115-119.
    • (1992) J. Nutr. , vol.122 , pp. 115-119
    • Gugger, E.T.1    Bierer, T.L.2    Henze, T.M.3    White, W.S.4
  • 141
    • 77957790873 scopus 로고    scopus 로고
    • beta-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-alpha
    • Kameji, H., Mochizuki, K., Miyoshi, N., Goda, T., beta-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-alpha. Nutrition 2010, 26, 1151-1156.
    • (2010) Nutrition , vol.26 , pp. 1151-1156
    • Kameji, H.1    Mochizuki, K.2    Miyoshi, N.3    Goda, T.4
  • 142
    • 74049106642 scopus 로고    scopus 로고
    • Comparative effects of beta-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats
    • Sangeetha, R. K., Bhaskar, N., Baskaran, V., Comparative effects of beta-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats. Mol. Cell. Biochem. 2009, 331, 59-67.
    • (2009) Mol. Cell. Biochem. , vol.331 , pp. 59-67
    • Sangeetha, R.K.1    Bhaskar, N.2    Baskaran, V.3
  • 143
    • 84861118896 scopus 로고    scopus 로고
    • Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet
    • Kim, J. E., Clark, R. M., Park, Y., Lee, J. et al., Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet. Nutr. Res. Pract. 2012, 6, 113-119.
    • (2012) Nutr. Res. Pract. , vol.6 , pp. 113-119
    • Kim, J.E.1    Clark, R.M.2    Park, Y.3    Lee, J.4
  • 144
    • 71149121153 scopus 로고    scopus 로고
    • Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice
    • Woo, M. N., Jeon, S. M., Shin, Y. C., Lee, M. K. et al., Anti-obese property of fucoxanthin is partly mediated by altering lipid-regulating enzymes and uncoupling proteins of visceral adipose tissue in mice. Mol. Nutr. Food Res. 2009, 53, 1603-1611.
    • (2009) Mol. Nutr. Food Res. , vol.53 , pp. 1603-1611
    • Woo, M.N.1    Jeon, S.M.2    Shin, Y.C.3    Lee, M.K.4
  • 145
    • 73649136846 scopus 로고    scopus 로고
    • Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model
    • Maeda, H., Hosokawa, M., Sashima, T., Murakami-Funayama, K. et al., Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model. Mol. Med. Rep. 2009, 2, 897-902.
    • (2009) Mol. Med. Rep. , vol.2 , pp. 897-902
    • Maeda, H.1    Hosokawa, M.2    Sashima, T.3    Murakami-Funayama, K.4
  • 146
    • 77954385541 scopus 로고    scopus 로고
    • Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice
    • Woo, M. N., Jeon, S. M., Kim, H. J., Lee, M. K. et al., Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice. Chem. Biol. Interact. 2010, 186, 316-322.
    • (2010) Chem. Biol. Interact. , vol.186 , pp. 316-322
    • Woo, M.N.1    Jeon, S.M.2    Kim, H.J.3    Lee, M.K.4
  • 147
    • 77957926292 scopus 로고    scopus 로고
    • Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice
    • Hosokawa, M., Miyashita, T., Nishikawa, S., Emi, S. et al., Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice. Arch. Biochem. Biophys. 2010, 504, 17-25.
    • (2010) Arch. Biochem. Biophys. , vol.504 , pp. 17-25
    • Hosokawa, M.1    Miyashita, T.2    Nishikawa, S.3    Emi, S.4
  • 148
    • 84880574008 scopus 로고    scopus 로고
    • Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-A(y) mice
    • Beppu, F., Hosokawa, M., Yim, M. J., Shinoda, T. et al., Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-A(y) mice. Lipids 2013, 48, 449-455.
    • (2013) Lipids , vol.48 , pp. 449-455
    • Beppu, F.1    Hosokawa, M.2    Yim, M.J.3    Shinoda, T.4
  • 149
    • 63449137594 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia
    • Zhu, F. S., Liu, S., Chen, X. M., Huang, Z. G. et al., Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. World J. Gastroenterol. 2008, 14, 6395-6400.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 6395-6400
    • Zhu, F.S.1    Liu, S.2    Chen, X.M.3    Huang, Z.G.4
  • 150
    • 84878006961 scopus 로고    scopus 로고
    • Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial
    • Janczyk, W., Socha, P., Lebensztejn, D., Wierzbicka, A. et al., Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. BMC Pediatr. 2013, 13, 85.
    • (2013) BMC Pediatr. , vol.13 , pp. 85
    • Janczyk, W.1    Socha, P.2    Lebensztejn, D.3    Wierzbicka, A.4
  • 151
    • 77649216380 scopus 로고    scopus 로고
    • Review article: omega-3 fatty acids-a promising novel therapy for non-alcoholic fatty liver disease
    • Masterton, G. S., Plevris, J. N., Hayes, P. C., Review article: omega-3 fatty acids-a promising novel therapy for non-alcoholic fatty liver disease. Aliment. Pharmacol. Ther. 2010, 31, 679-692.
    • (2010) Aliment. Pharmacol. Ther. , vol.31 , pp. 679-692
    • Masterton, G.S.1    Plevris, J.N.2    Hayes, P.C.3
  • 152
    • 64149106016 scopus 로고    scopus 로고
    • n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet
    • Kuda, O., Jelenik, T., Jilkova, Z., Flachs, P. et al., n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet. Diabetologia 2009, 52, 941-951.
    • (2009) Diabetologia , vol.52 , pp. 941-951
    • Kuda, O.1    Jelenik, T.2    Jilkova, Z.3    Flachs, P.4
  • 154
    • 41349102802 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
    • Tanaka, N., Sano, K., Horiuchi, A., Tanaka, E. et al., Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis. J. Clin. Gastroenterol. 2008, 42, 413-418.
    • (2008) J. Clin. Gastroenterol. , vol.42 , pp. 413-418
    • Tanaka, N.1    Sano, K.2    Horiuchi, A.3    Tanaka, E.4
  • 155
    • 77957854056 scopus 로고    scopus 로고
    • Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women
    • Oya, J., Nakagami, T., Sasaki, S., Jimba, S. et al., Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. Eur. J. Clin. Nutr. 2010, 64, 1179-1185.
    • (2010) Eur. J. Clin. Nutr. , vol.64 , pp. 1179-1185
    • Oya, J.1    Nakagami, T.2    Sasaki, S.3    Jimba, S.4
  • 156
    • 70350072643 scopus 로고    scopus 로고
    • Ethyl-eicosapentaenoic acid reduces liver lipids and lowers plasma levels of lipids in mice fed a high-fat diet
    • Nemoto, N., Suzuki, S., Kikuchi, H., Okabe, H. et al., Ethyl-eicosapentaenoic acid reduces liver lipids and lowers plasma levels of lipids in mice fed a high-fat diet. In Vivo 2009, 23, 685-689.
    • (2009) In Vivo , vol.23 , pp. 685-689
    • Nemoto, N.1    Suzuki, S.2    Kikuchi, H.3    Okabe, H.4
  • 157
    • 84855273013 scopus 로고    scopus 로고
    • Regulation of lipid metabolism by palmitoleate and eicosapentaenoic acid (EPA) in mice fed a high-fat diet
    • Shiba, S., Tsunoda, N., Wakutsu, M., Muraki, E. et al., Regulation of lipid metabolism by palmitoleate and eicosapentaenoic acid (EPA) in mice fed a high-fat diet. Biosci. Biotechnol. Biochem. 2011, 75, 2401-2403.
    • (2011) Biosci. Biotechnol. Biochem. , vol.75 , pp. 2401-2403
    • Shiba, S.1    Tsunoda, N.2    Wakutsu, M.3    Muraki, E.4
  • 158
    • 62249144304 scopus 로고    scopus 로고
    • Suppression of hepatic fat accumulation by highly purified eicosapentaenoic acid prevents the progression of d-galactosamine-induced hepatitis in mice fed with a high-fat/high-sucrose diet
    • Kajikawa, S., Harada, T., Kawashima, A., Imada, K. et al., Suppression of hepatic fat accumulation by highly purified eicosapentaenoic acid prevents the progression of d-galactosamine-induced hepatitis in mice fed with a high-fat/high-sucrose diet. Biochim. Biophys. Acta 2009, 1791, 281-288.
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 281-288
    • Kajikawa, S.1    Harada, T.2    Kawashima, A.3    Imada, K.4
  • 159
    • 77954842591 scopus 로고    scopus 로고
    • Medaka as a model for human nonalcoholic steatohepatitis
    • Matsumoto, T., Terai, S., Oishi, T., Kuwashiro, S. et al., Medaka as a model for human nonalcoholic steatohepatitis. Dis. Model. Mech. 2010, 3, 431-440.
    • (2010) Dis. Model. Mech. , vol.3 , pp. 431-440
    • Matsumoto, T.1    Terai, S.2    Oishi, T.3    Kuwashiro, S.4
  • 160
    • 59649095416 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and animal models: understanding the human disease
    • Varela-Rey, M., Embade, N., Ariz, U., Lu, S. C. et al., Non-alcoholic steatohepatitis and animal models: understanding the human disease. Int. J. Biochem. Cell Biol. 2009, 41, 969-976.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 969-976
    • Varela-Rey, M.1    Embade, N.2    Ariz, U.3    Lu, S.C.4
  • 161
    • 79955589142 scopus 로고    scopus 로고
    • Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet
    • Kajikawa, S., Imada, K., Takeuchi, T., Shimizu, Y. et al., Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet. Dig. Dis. Sci. 2011, 56, 1065-1074.
    • (2011) Dig. Dis. Sci. , vol.56 , pp. 1065-1074
    • Kajikawa, S.1    Imada, K.2    Takeuchi, T.3    Shimizu, Y.4
  • 162
    • 77949313797 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid ethyl ester prevents development of steatosis and hepatic fibrosis in rats
    • Kajikawa, S., Harada, T., Kawashima, A., Imada, K. et al., Highly purified eicosapentaenoic acid ethyl ester prevents development of steatosis and hepatic fibrosis in rats. Dig. Dis. Sci. 2010, 55, 631-641.
    • (2010) Dig. Dis. Sci. , vol.55 , pp. 631-641
    • Kajikawa, S.1    Harada, T.2    Kawashima, A.3    Imada, K.4
  • 163
    • 59349092761 scopus 로고    scopus 로고
    • Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice
    • Ishii, H., Horie, Y., Ohshima, S., Anezaki, Y. et al., Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J. Hepatol. 2009, 50, 562-571.
    • (2009) J. Hepatol. , vol.50 , pp. 562-571
    • Ishii, H.1    Horie, Y.2    Ohshima, S.3    Anezaki, Y.4
  • 164
    • 84878884455 scopus 로고    scopus 로고
    • Oxidized eicosapentaenoic acids more potently reduce LXRalpha-induced cellular triacylglycerol via suppression of SREBP-1c, PGC-1beta and GPA than its intact form
    • Nanthirudjanar, T., Furumoto, H., Hirata, T., Sugawara, T., Oxidized eicosapentaenoic acids more potently reduce LXRalpha-induced cellular triacylglycerol via suppression of SREBP-1c, PGC-1beta and GPA than its intact form. Lipids Health Dis. 2013, 12, 73.
    • (2013) Lipids Health Dis. , vol.12 , pp. 73
    • Nanthirudjanar, T.1    Furumoto, H.2    Hirata, T.3    Sugawara, T.4
  • 165
    • 79953177813 scopus 로고    scopus 로고
    • Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial
    • Nobili, V., Bedogni, G., Alisi, A., Pietrobattista, A. et al., Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. Arch. Dis. Child. 2011, 96, 350-353.
    • (2011) Arch. Dis. Child. , vol.96 , pp. 350-353
    • Nobili, V.1    Bedogni, G.2    Alisi, A.3    Pietrobattista, A.4
  • 166
    • 84887614661 scopus 로고    scopus 로고
    • Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children
    • in press.
    • Nobili, V., Alisi, A., Della, C. C., Rise, P. et al., Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. Nutr. Metab. Cardiovasc. Dis. 2012, in press.
    • (2012) Nutr. Metab. Cardiovasc. Dis.
    • Nobili, V.1    Alisi, A.2    Della, C.C.3    Rise, P.4
  • 167
    • 77954353061 scopus 로고    scopus 로고
    • Effects of docosahexaenoic acid in an experimental rat model of nonalcoholic steatohepatitis
    • Takayama, F., Nakamoto, K., Totani, N., Yamanushi, T. et al., Effects of docosahexaenoic acid in an experimental rat model of nonalcoholic steatohepatitis. J. Oleo. Sci. 2010, 59, 407-414.
    • (2010) J. Oleo. Sci. , vol.59 , pp. 407-414
    • Takayama, F.1    Nakamoto, K.2    Totani, N.3    Yamanushi, T.4
  • 168
    • 84878014437 scopus 로고    scopus 로고
    • Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
    • Poudyal, H., Panchal, S. K., Ward, L. C., Brown, L., Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. J. Nutr. Biochem. 2013, 24, 1041-1052.
    • (2013) J. Nutr. Biochem. , vol.24 , pp. 1041-1052
    • Poudyal, H.1    Panchal, S.K.2    Ward, L.C.3    Brown, L.4
  • 169
    • 84861899192 scopus 로고    scopus 로고
    • Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet
    • Tang, X., Li, Z. J., Xu, J., Xue, Y. et al., Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet. Lipids Health Dis. 2012, 11, 70.
    • (2012) Lipids Health Dis. , vol.11 , pp. 70
    • Tang, X.1    Li, Z.J.2    Xu, J.3    Xue, Y.4
  • 170
    • 84874682905 scopus 로고    scopus 로고
    • Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis
    • Depner, C. M., Philbrick, K. A., Jump, D. B., Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. J. Nutr. 2013, 143, 315-323.
    • (2013) J. Nutr. , vol.143 , pp. 315-323
    • Depner, C.M.1    Philbrick, K.A.2    Jump, D.B.3
  • 171
    • 54549120218 scopus 로고    scopus 로고
    • Dietary docosahexaenoic acid-rich diacylglycerols ameliorate hepatic steatosis and alter hepatic gene expressions in C57BL/6J-Lep(ob/ob) mice
    • Kim, H. J., Lee, K. T., Park, Y. B., Jeon, S. M. et al., Dietary docosahexaenoic acid-rich diacylglycerols ameliorate hepatic steatosis and alter hepatic gene expressions in C57BL/6J-Lep(ob/ob) mice. Mol. Nutr. Food Res. 2008, 52, 965-973.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 965-973
    • Kim, H.J.1    Lee, K.T.2    Park, Y.B.3    Jeon, S.M.4
  • 172
    • 84861739927 scopus 로고    scopus 로고
    • Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation
    • Fedor, D. M., Adkins, Y., Mackey, B. E., Kelley, D. S., Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation. Metab. Syndr. Relat. Disord. 2012, 10, 175-180.
    • (2012) Metab. Syndr. Relat. Disord. , vol.10 , pp. 175-180
    • Fedor, D.M.1    Adkins, Y.2    Mackey, B.E.3    Kelley, D.S.4
  • 173
    • 36749024519 scopus 로고    scopus 로고
    • Docosahexaenoic acid (DHA) but not eicosapentaenoic acid (EPA) prevents trans-10, cis-12 conjugated linoleic acid (CLA)-induced insulin resistance in mice
    • Vemuri, M., Kelley, D. S., Mackey, B. E., Rasooly, R. et al., Docosahexaenoic acid (DHA) but not eicosapentaenoic acid (EPA) prevents trans-10, cis-12 conjugated linoleic acid (CLA)-induced insulin resistance in mice. Metab. Syndr.Relat. Disord. 2007, 5, 315-322.
    • (2007) Metab. Syndr.Relat. Disord. , vol.5 , pp. 315-322
    • Vemuri, M.1    Kelley, D.S.2    Mackey, B.E.3    Rasooly, R.4
  • 174
    • 84862235241 scopus 로고    scopus 로고
    • Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells
    • Luo, X., Yang, Y., Shen, T., Tang, X. et al., Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells. Nutr. Metab. (Lond.) 2012, 9, 34.
    • (2012) Nutr. Metab. (Lond.) , vol.9 , pp. 34
    • Luo, X.1    Yang, Y.2    Shen, T.3    Tang, X.4
  • 175
    • 29444448615 scopus 로고    scopus 로고
    • Intake of conjugated eicosapentaenoic acid suppresses lipid accumulation in liver and epididymal adipose tissue in rats
    • Tsuzuki, T., Kawakami, Y., Suzuki, Y., Abe, R. et al., Intake of conjugated eicosapentaenoic acid suppresses lipid accumulation in liver and epididymal adipose tissue in rats. Lipids 2005, 40, 1117-1123.
    • (2005) Lipids , vol.40 , pp. 1117-1123
    • Tsuzuki, T.1    Kawakami, Y.2    Suzuki, Y.3    Abe, R.4
  • 176
    • 79951576892 scopus 로고    scopus 로고
    • DHA regulates lipogenesis and lipolysis genes in mice adipose and liver
    • Sun, C., Wei, Z. W., Li, Y., DHA regulates lipogenesis and lipolysis genes in mice adipose and liver. Mol. Biol. Rep. 2011, 38, 731-737.
    • (2011) Mol. Biol. Rep. , vol.38 , pp. 731-737
    • Sun, C.1    Wei, Z.W.2    Li, Y.3
  • 177
    • 84890795801 scopus 로고    scopus 로고
    • Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner
    • Gladine, C., Roy, N. C., Rigaudiere, J. P., Laillet, B. et al., Increasing intake of long-chain n-3 PUFA enhances lipoperoxidation and modulates hepatic gene expression in a dose-dependent manner. Br. J. Nutr. 2011, 1-20.
    • (2011) Br. J. Nutr. , pp. 1-20
    • Gladine, C.1    Roy, N.C.2    Rigaudiere, J.P.3    Laillet, B.4
  • 178
    • 84255176302 scopus 로고    scopus 로고
    • Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells
    • Ono, M., Fujimori, K., Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells. J. Agric. Food Chem. 2011, 59, 13346-13352.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 13346-13352
    • Ono, M.1    Fujimori, K.2
  • 179
    • 79953220498 scopus 로고    scopus 로고
    • Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress
    • Liu, J. F., Ma, Y., Wang, Y., Du, Z. Y. et al., Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress. Phytother. Res. 2011, 25, 588-596.
    • (2011) Phytother. Res. , vol.25 , pp. 588-596
    • Liu, J.F.1    Ma, Y.2    Wang, Y.3    Du, Z.Y.4
  • 180
    • 61849093805 scopus 로고    scopus 로고
    • Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion
    • Kunimasa, K., Kuranuki, S., Matsuura, N., Iwasaki, N. et al., Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion. Bioorg. Med. Chem. Lett. 2009, 19, 2062-2064.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2062-2064
    • Kunimasa, K.1    Kuranuki, S.2    Matsuura, N.3    Iwasaki, N.4
  • 181
    • 77950078871 scopus 로고    scopus 로고
    • Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice
    • Lee, Y. S., Cha, B. Y., Saito, K., Yamakawa, H. et al., Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. Biochem. Pharmacol. 2010, 79, 1674-1683.
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1674-1683
    • Lee, Y.S.1    Cha, B.Y.2    Saito, K.3    Yamakawa, H.4
  • 182
    • 84870414386 scopus 로고    scopus 로고
    • Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice
    • Lee, Y. S., Cha, B. Y., Choi, S. S., Choi, B. K. et al., Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. J. Nutr. Biochem. 2013, 24, 156-162.
    • (2013) J. Nutr. Biochem. , vol.24 , pp. 156-162
    • Lee, Y.S.1    Cha, B.Y.2    Choi, S.S.3    Choi, B.K.4
  • 183
    • 79952700752 scopus 로고    scopus 로고
    • Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin
    • Miyata, Y., Tanaka, H., Shimada, A., Sato, T. et al., Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin. Life Sci. 2011, 88, 613-618.
    • (2011) Life Sci. , vol.88 , pp. 613-618
    • Miyata, Y.1    Tanaka, H.2    Shimada, A.3    Sato, T.4
  • 184
    • 84865302623 scopus 로고    scopus 로고
    • Baicalein, a natural product, selectively activating AMPKalpha(2) and ameliorates metabolic disorder in diet-induced mice
    • Pu, P., Wang, X. A., Salim, M., Zhu, L. H. et al., Baicalein, a natural product, selectively activating AMPKalpha(2) and ameliorates metabolic disorder in diet-induced mice. Mol. Cell. Endocrinol. 2012, 362, 128-138.
    • (2012) Mol. Cell. Endocrinol. , vol.362 , pp. 128-138
    • Pu, P.1    Wang, X.A.2    Salim, M.3    Zhu, L.H.4
  • 185
    • 84863550183 scopus 로고    scopus 로고
    • Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats
    • Panchal, S. K., Poudyal, H., Brown, L., Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. J. Nutr. 2012, 142, 1026-1032.
    • (2012) J. Nutr. , vol.142 , pp. 1026-1032
    • Panchal, S.K.1    Poudyal, H.2    Brown, L.3
  • 186
    • 84872089657 scopus 로고    scopus 로고
    • Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes
    • Jung, C. H., Cho, I., Ahn, J., Jeon, T. I. et al., Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes. Phytother. Res. 2013, 27, 139-143.
    • (2013) Phytother. Res. , vol.27 , pp. 139-143
    • Jung, C.H.1    Cho, I.2    Ahn, J.3    Jeon, T.I.4
  • 187
    • 84872837874 scopus 로고    scopus 로고
    • Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice
    • Hoek-van den Hil E. F., Keijer, J., Bunschoten, A., Vervoort, J. J. et al., Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice. PLoS One 2013, 8, e51588.
    • (2013) PLoS One , vol.8
    • Hoek-van den Hil, E.F.1    Keijer, J.2    Bunschoten, A.3    Vervoort, J.J.4
  • 188
    • 84869869189 scopus 로고    scopus 로고
    • Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils
    • Ying, H. Z., Liu, Y. H., Yu, B., Wang, Z. Y. et al., Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils. Food Chem. Toxicol. 2013, 52, 53-60.
    • (2013) Food Chem. Toxicol. , vol.52 , pp. 53-60
    • Ying, H.Z.1    Liu, Y.H.2    Yu, B.3    Wang, Z.Y.4
  • 189
    • 84869121923 scopus 로고    scopus 로고
    • Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis
    • Marcolin, E., San-Miguel, B., Vallejo, D., Tieppo, J. et al., Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. J. Nutr. 2012, 142, 1821-1828.
    • (2012) J. Nutr. , vol.142 , pp. 1821-1828
    • Marcolin, E.1    San-Miguel, B.2    Vallejo, D.3    Tieppo, J.4
  • 191
    • 84864236699 scopus 로고    scopus 로고
    • Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice
    • Jeong, S. M., Kang, M. J., Choi, H. N., Kim, J. H. et al., Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice. Nutr. Res. Pract. 2012, 6, 201-207.
    • (2012) Nutr. Res. Pract. , vol.6 , pp. 201-207
    • Jeong, S.M.1    Kang, M.J.2    Choi, H.N.3    Kim, J.H.4
  • 192
    • 84873696060 scopus 로고    scopus 로고
    • Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells
    • Vidyashankar, S., Sandeep, V. R., Patki, P. S., Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells. Toxicol. In Vitro 2013, 27, 945-953.
    • (2013) Toxicol. In Vitro , vol.27 , pp. 945-953
    • Vidyashankar, S.1    Sandeep, V.R.2    Patki, P.S.3
  • 193
    • 40849085134 scopus 로고    scopus 로고
    • Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells
    • Crespo, I., Garcia-Mediavilla, M. V., Almar, M., Gonzalez, P. et al., Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells. Food Chem. Toxicol. 2008, 46, 1555-1569.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 1555-1569
    • Crespo, I.1    Garcia-Mediavilla, M.V.2    Almar, M.3    Gonzalez, P.4
  • 194
    • 48549096915 scopus 로고    scopus 로고
    • Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet
    • Kuzu, N., Bahcecioglu, I. H., Dagli, A. F., Ozercan, I. H. et al., Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet. J. Gastroenterol. Hepatol. 2008, 23, e465-e470.
    • (2008) J. Gastroenterol. Hepatol. , vol.23
    • Kuzu, N.1    Bahcecioglu, I.H.2    Dagli, A.F.3    Ozercan, I.H.4
  • 195
    • 51049094422 scopus 로고    scopus 로고
    • The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice
    • Bose, M., Lambert, J. D., Ju, J., Reuhl, K. R. et al., The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J. Nutr. 2008, 138, 1677-1683.
    • (2008) J. Nutr. , vol.138 , pp. 1677-1683
    • Bose, M.1    Lambert, J.D.2    Ju, J.3    Reuhl, K.R.4
  • 196
    • 80455140635 scopus 로고    scopus 로고
    • Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice
    • Chen, Y. K., Cheung, C., Reuhl, K. R., Liu, A. B. et al., Effects of green tea polyphenol (-)-epigallocatechin-3-gallate on newly developed high-fat/Western-style diet-induced obesity and metabolic syndrome in mice. J. Agric. Food Chem. 2011, 59, 11862-11871.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 11862-11871
    • Chen, Y.K.1    Cheung, C.2    Reuhl, K.R.3    Liu, A.B.4
  • 197
    • 84895076381 scopus 로고    scopus 로고
    • Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways
    • in press.
    • Xiao, J., Ho, C. T., Liong, E. C., Nanji, A. A. et al., Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways. Eur. J. Nutr. 2013, in press.
    • (2013) Eur. J. Nutr.
    • Xiao, J.1    Ho, C.T.2    Liong, E.C.3    Nanji, A.A.4
  • 198
    • 20044383992 scopus 로고    scopus 로고
    • Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation
    • Klaus, S., Pultz, S., Thone-Reineke, C., Wolfram, S., Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. Int. J. Obes. (Lond.) 2005, 29, 615-623.
    • (2005) Int. J. Obes. (Lond.) , vol.29 , pp. 615-623
    • Klaus, S.1    Pultz, S.2    Thone-Reineke, C.3    Wolfram, S.4
  • 199
    • 84860781440 scopus 로고    scopus 로고
    • Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet
    • Friedrich, M., Petzke, K. J., Raederstorff, D., Wolfram, S. et al., Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet. Int. J. Obes. (Lond.) 2012, 36, 735-743.
    • (2012) Int. J. Obes. (Lond.) , vol.36 , pp. 735-743
    • Friedrich, M.1    Petzke, K.J.2    Raederstorff, D.3    Wolfram, S.4
  • 200
    • 35848970056 scopus 로고    scopus 로고
    • Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
    • Lin, C. L., Huang, H. C., Lin, J. K., Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. J. Lipid Res. 2007, 48, 2334-2343.
    • (2007) J. Lipid Res. , vol.48 , pp. 2334-2343
    • Lin, C.L.1    Huang, H.C.2    Lin, J.K.3
  • 201
    • 84855775173 scopus 로고    scopus 로고
    • Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model
    • Luo, X. Y., Takahara, T., Hou, J., Kawai, K. et al., Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model. Biochem. Biophys. Res. Commun. 2012, 417, 287-293.
    • (2012) Biochem. Biophys. Res. Commun. , vol.417 , pp. 287-293
    • Luo, X.Y.1    Takahara, T.2    Hou, J.3    Kawai, K.4
  • 202
    • 33645985463 scopus 로고    scopus 로고
    • Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids
    • Huong, D. T., Takahashi, Y., Ide, T., Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids. Nutrition 2006, 22, 546-552.
    • (2006) Nutrition , vol.22 , pp. 546-552
    • Huong, D.T.1    Takahashi, Y.2    Ide, T.3
  • 203
    • 70349651441 scopus 로고    scopus 로고
    • Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance
    • Mulvihill, E. E., Allister, E. M., Sutherland, B. G., Telford, D. E. et al., Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 2009, 58, 2198-2210.
    • (2009) Diabetes , vol.58 , pp. 2198-2210
    • Mulvihill, E.E.1    Allister, E.M.2    Sutherland, B.G.3    Telford, D.E.4
  • 204
    • 84874025229 scopus 로고    scopus 로고
    • Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr(-)/(-) mice
    • Assini, J. M., Mulvihill, E. E., Sutherland, B. G., Telford, D. E. et al., Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr(-)/(-) mice. J. Lipid Res. 2013, 54, 711-724.
    • (2013) J. Lipid Res. , vol.54 , pp. 711-724
    • Assini, J.M.1    Mulvihill, E.E.2    Sutherland, B.G.3    Telford, D.E.4
  • 205
    • 0034792836 scopus 로고    scopus 로고
    • Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats
    • Cha, J. Y., Cho, Y. S., Kim, I., Anno, T. et al., Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats. Plant Foods Hum. Nutr. 2001, 56, 349-358.
    • (2001) Plant Foods Hum. Nutr. , vol.56 , pp. 349-358
    • Cha, J.Y.1    Cho, Y.S.2    Kim, I.3    Anno, T.4
  • 206
    • 0014743725 scopus 로고
    • General survey of diabetic features of yellow KK mice
    • Iwatsuka, H., Shino, A., Suzuoki, Z., General survey of diabetic features of yellow KK mice. Endocrinol. Jpn. 1970, 17, 23-35.
    • (1970) Endocrinol. Jpn. , vol.17 , pp. 23-35
    • Iwatsuka, H.1    Shino, A.2    Suzuoki, Z.3
  • 207
    • 79954989314 scopus 로고    scopus 로고
    • Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCzeta
    • Guo, H., Li, D., Ling, W., Feng, X. et al., Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCzeta. J. Lipid Res. 2011, 52, 908-922.
    • (2011) J. Lipid Res. , vol.52 , pp. 908-922
    • Guo, H.1    Li, D.2    Ling, W.3    Feng, X.4
  • 208
    • 84858290692 scopus 로고    scopus 로고
    • Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1
    • Guo, H., Xia, M., Zou, T., Ling, W. et al., Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. J. Nutr. Biochem. 2012, 23, 349-360.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 349-360
    • Guo, H.1    Xia, M.2    Zou, T.3    Ling, W.4
  • 209
    • 84855421010 scopus 로고    scopus 로고
    • The anthocyanin cyanidin-3-O-beta-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: involvement of a cAMP-PKA-dependent signaling pathway
    • Zhu, W., Jia, Q., Wang, Y., Zhang, Y. et al., The anthocyanin cyanidin-3-O-beta-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: involvement of a cAMP-PKA-dependent signaling pathway. Free Radic. Biol. Med. 2012, 52, 314-327.
    • (2012) Free Radic. Biol. Med. , vol.52 , pp. 314-327
    • Zhu, W.1    Jia, Q.2    Wang, Y.3    Zhang, Y.4
  • 210
    • 84855741955 scopus 로고    scopus 로고
    • Cyanidin-3-O-beta-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells
    • Guo, H., Liu, G., Zhong, R., Wang, Y. et al., Cyanidin-3-O-beta-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells. Lipids Health Dis. 2012, 11, 10.
    • (2012) Lipids Health Dis. , vol.11 , pp. 10
    • Guo, H.1    Liu, G.2    Zhong, R.3    Wang, Y.4
  • 211
    • 80051598136 scopus 로고    scopus 로고
    • Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism
    • Kim, M. H., Park, J. S., Jung, J. W., Byun, K. W. et al., Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism. Int. J. Obes.(Lond.) 2011, 35, 1019-1030.
    • (2011) Int. J. Obes.(Lond.) , vol.35 , pp. 1019-1030
    • Kim, M.H.1    Park, J.S.2    Jung, J.W.3    Byun, K.W.4
  • 212
    • 81355134433 scopus 로고    scopus 로고
    • Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity
    • Crespillo, A., Alonso, M., Vida, M., Pavon, F. J. et al., Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity. Br. J. Pharmacol. 2011, 164, 1899-1915.
    • (2011) Br. J. Pharmacol. , vol.164 , pp. 1899-1915
    • Crespillo, A.1    Alonso, M.2    Vida, M.3    Pavon, F.J.4
  • 213
    • 68549110210 scopus 로고    scopus 로고
    • A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver
    • Takahashi, Y., Odbayar, T. O., Ide, T., A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver. J. Clin. Biochem. Nutr. 2009, 44, 223-230.
    • (2009) J. Clin. Biochem. Nutr. , vol.44 , pp. 223-230
    • Takahashi, Y.1    Odbayar, T.O.2    Ide, T.3
  • 214
    • 33645127006 scopus 로고    scopus 로고
    • Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine
    • Shin, E. S., Cho, S. Y., Lee, E. H., Lee, S. J. et al., Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine. Eur. J. Nutr. 2006, 45, 159-164.
    • (2006) Eur. J. Nutr. , vol.45 , pp. 159-164
    • Shin, E.S.1    Cho, S.Y.2    Lee, E.H.3    Lee, S.J.4
  • 215
    • 2942529395 scopus 로고    scopus 로고
    • Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha
    • Kim, S., Shin, H. J., Kim, S. Y., Kim, J. H. et al., Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha. Mol. Cell. Endocrinol. 2004, 220, 51-58.
    • (2004) Mol. Cell. Endocrinol. , vol.220 , pp. 51-58
    • Kim, S.1    Shin, H.J.2    Kim, S.Y.3    Kim, J.H.4
  • 216
    • 34247891519 scopus 로고    scopus 로고
    • Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells
    • Shin, E. S., Lee, H. H., Cho, S. Y., Park, H. W. et al., Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells. J. Nutr. 2007, 137, 1127-1131.
    • (2007) J. Nutr. , vol.137 , pp. 1127-1131
    • Shin, E.S.1    Lee, H.H.2    Cho, S.Y.3    Park, H.W.4
  • 217
    • 78149482135 scopus 로고    scopus 로고
    • The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease
    • Kim, M. H., Kang, K. S., Lee, Y. S., The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease. Br. J. Nutr. 2010, 104, 1333-1342.
    • (2010) Br. J. Nutr. , vol.104 , pp. 1333-1342
    • Kim, M.H.1    Kang, K.S.2    Lee, Y.S.3
  • 218
    • 34948848563 scopus 로고    scopus 로고
    • Preventive role of genistein in an experimental non-alcoholic steatohepatitis model
    • Yalniz, M., Bahcecioglu, I. H., Kuzu, N., Poyrazoglu, O. K. et al., Preventive role of genistein in an experimental non-alcoholic steatohepatitis model. J. Gastroenterol. Hepatol. 2007, 22, 2009-2014.
    • (2007) J. Gastroenterol. Hepatol. , vol.22 , pp. 2009-2014
    • Yalniz, M.1    Bahcecioglu, I.H.2    Kuzu, N.3    Poyrazoglu, O.K.4
  • 219
    • 33747175979 scopus 로고    scopus 로고
    • Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets
    • Lee, Y. M., Choi, J. S., Kim, M. H., Jung, M. H. et al., Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets. Nutrition 2006, 22, 956-964.
    • (2006) Nutrition , vol.22 , pp. 956-964
    • Lee, Y.M.1    Choi, J.S.2    Kim, M.H.3    Jung, M.H.4
  • 220
    • 79960128744 scopus 로고    scopus 로고
    • Neonatal exposure to genistein ameliorates high-fat diet-induced non-alcoholic steatohepatitis in rats
    • Huang, C., Qiao, X., Dong, B., Neonatal exposure to genistein ameliorates high-fat diet-induced non-alcoholic steatohepatitis in rats. Br. J. Nutr. 2011, 106, 105-113.
    • (2011) Br. J. Nutr. , vol.106 , pp. 105-113
    • Huang, C.1    Qiao, X.2    Dong, B.3
  • 221
    • 79955850387 scopus 로고    scopus 로고
    • Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms
    • Ji, G., Yang, Q., Hao, J., Guo, L. et al., Anti-inflammatory effect of genistein on non-alcoholic steatohepatitis rats induced by high fat diet and its potential mechanisms. Int. Immunopharmacol. 2011, 11, 762-768.
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 762-768
    • Ji, G.1    Yang, Q.2    Hao, J.3    Guo, L.4
  • 222
    • 77955056005 scopus 로고    scopus 로고
    • Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance
    • Mohamed, S. S., Nallasamy, P., Muniyandi, P., Periyasami, V. et al., Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance. J. Diabetes 2009, 1, 278-287.
    • (2009) J. Diabetes , vol.1 , pp. 278-287
    • Mohamed, S.S.1    Nallasamy, P.2    Muniyandi, P.3    Periyasami, V.4
  • 223
    • 84879353742 scopus 로고    scopus 로고
    • Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat-high-fructose diet-fed mice
    • Arunkumar, E., Karthik, D., Anuradha, C. V., Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat-high-fructose diet-fed mice. Pharm. Biol. 2013, 51, 815-824.
    • (2013) Pharm. Biol. , vol.51 , pp. 815-824
    • Arunkumar, E.1    Karthik, D.2    Anuradha, C.V.3
  • 224
    • 33746591715 scopus 로고    scopus 로고
    • Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice
    • Ae, P. S., Choi, M. S., Cho, S. Y., Seo, J. S. et al., Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci. 2006, 79, 1207-1213.
    • (2006) Life Sci. , vol.79 , pp. 1207-1213
    • Ae, P.S.1    Choi, M.S.2    Cho, S.Y.3    Seo, J.S.4
  • 225
    • 79957982869 scopus 로고    scopus 로고
    • Genistein reverses free fatty acid-induced insulin resistance in HepG2 hepatocytes through targeting JNK
    • Lei, H., Lu, F., Dong, H., Xu, L. et al., Genistein reverses free fatty acid-induced insulin resistance in HepG2 hepatocytes through targeting JNK. J. Huazhong Univ. Sci. Technolog. Med. Sci. 2011, 31, 185-189.
    • (2011) J. Huazhong Univ. Sci. Technolog. Med. Sci. , vol.31 , pp. 185-189
    • Lei, H.1    Lu, F.2    Dong, H.3    Xu, L.4
  • 226
    • 44849131936 scopus 로고    scopus 로고
    • Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
    • Shang, J., Chen, L. L., Xiao, F. X., Sun, H. et al., Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase. Acta Pharmacol. Sin. 2008, 29, 698-706.
    • (2008) Acta Pharmacol. Sin. , vol.29 , pp. 698-706
    • Shang, J.1    Chen, L.L.2    Xiao, F.X.3    Sun, H.4
  • 227
    • 84861846116 scopus 로고    scopus 로고
    • Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet
    • Jeon, B. T., Jeong, E. A., Shin, H. J., Lee, Y. et al., Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet. Diabetes 2012, 61, 1444-1454.
    • (2012) Diabetes , vol.61 , pp. 1444-1454
    • Jeon, B.T.1    Jeong, E.A.2    Shin, H.J.3    Lee, Y.4
  • 228
    • 38049088068 scopus 로고    scopus 로고
    • Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters
    • Cho, I. J., Ahn, J. Y., Kim, S., Choi, M. S. et al., Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters. Biochem. Biophys. Res. Commun. 2008, 367, 190-194.
    • (2008) Biochem. Biophys. Res. Commun. , vol.367 , pp. 190-194
    • Cho, I.J.1    Ahn, J.Y.2    Kim, S.3    Choi, M.S.4
  • 229
    • 84855974972 scopus 로고    scopus 로고
    • Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress
    • Gomez-Zorita, S., Fernandez-Quintela, A., Macarulla, M. T., Aguirre, L. et al., Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress. Br. J. Nutr. 2012, 107, 202-210.
    • (2012) Br. J. Nutr. , vol.107 , pp. 202-210
    • Gomez-Zorita, S.1    Fernandez-Quintela, A.2    Macarulla, M.T.3    Aguirre, L.4
  • 230
    • 84873568768 scopus 로고    scopus 로고
    • Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet
    • Alberdi, G., Rodriguez, V. M., Macarulla, M. T., Miranda, J. et al., Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet. Nutrition 2013, 29, 562-567.
    • (2013) Nutrition , vol.29 , pp. 562-567
    • Alberdi, G.1    Rodriguez, V.M.2    Macarulla, M.T.3    Miranda, J.4
  • 231
    • 84865150391 scopus 로고    scopus 로고
    • Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice
    • Cho, S. J., Jung, U. J., Choi, M. S., Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice. Br. J. Nutr. 2012, 108, 2166-2175.
    • (2012) Br. J. Nutr. , vol.108 , pp. 2166-2175
    • Cho, S.J.1    Jung, U.J.2    Choi, M.S.3
  • 232
    • 55549097087 scopus 로고    scopus 로고
    • Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet
    • Ahn, J., Cho, I., Kim, S., Kwon, D. et al., Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet. J. Hepatol. 2008, 49, 1019-1028.
    • (2008) J. Hepatol. , vol.49 , pp. 1019-1028
    • Ahn, J.1    Cho, I.2    Kim, S.3    Kwon, D.4
  • 233
    • 84867858715 scopus 로고    scopus 로고
    • Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet
    • Poulsen, M. M., Larsen, J. O., Hamilton-Dutoit, S., Clasen, B. F. et al., Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet. Nutr. Res. 2012, 32, 701-708.
    • (2012) Nutr. Res. , vol.32 , pp. 701-708
    • Poulsen, M.M.1    Larsen, J.O.2    Hamilton-Dutoit, S.3    Clasen, B.F.4
  • 234
    • 84864277111 scopus 로고    scopus 로고
    • Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats
    • Bagul, P. K., Middela, H., Matapally, S., Padiya, R. et al., Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacol. Res. 2012, 66, 260-268.
    • (2012) Pharmacol. Res. , vol.66 , pp. 260-268
    • Bagul, P.K.1    Middela, H.2    Matapally, S.3    Padiya, R.4
  • 235
    • 52749094256 scopus 로고    scopus 로고
    • Resveratrol inhibits nonalcoholic fatty liver disease in rats
    • Bujanda, L., Hijona, E., Larzabal, M., Beraza, M. et al., Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol. 2008, 8, 40.
    • (2008) BMC Gastroenterol. , vol.8 , pp. 40
    • Bujanda, L.1    Hijona, E.2    Larzabal, M.3    Beraza, M.4
  • 236
    • 84857501565 scopus 로고    scopus 로고
    • Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents
    • Kang, W., Hong, H. J., Guan, J., Kim, D. G. et al., Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents. Metabolism 2012, 61, 424-433.
    • (2012) Metabolism , vol.61 , pp. 424-433
    • Kang, W.1    Hong, H.J.2    Guan, J.3    Kim, D.G.4
  • 237
    • 84863153155 scopus 로고    scopus 로고
    • Effects of resveratrol on the amelioration of insulin resistance in KKAy mice
    • Chen, S., Li, J., Zhang, Z., Li, W. et al., Effects of resveratrol on the amelioration of insulin resistance in KKAy mice. Can. J. Physiol. Pharmacol. 2012, 90, 237-242.
    • (2012) Can. J. Physiol. Pharmacol. , vol.90 , pp. 237-242
    • Chen, S.1    Li, J.2    Zhang, Z.3    Li, W.4
  • 238
    • 60549098942 scopus 로고    scopus 로고
    • Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway
    • Wang, G. L., Fu, Y. C., Xu, W. C., Feng, Y. Q. et al., Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway. Biochem. Biophys. Res. Commun. 2009, 380, 644-649.
    • (2009) Biochem. Biophys. Res. Commun. , vol.380 , pp. 644-649
    • Wang, G.L.1    Fu, Y.C.2    Xu, W.C.3    Feng, Y.Q.4
  • 239
    • 50649112638 scopus 로고    scopus 로고
    • SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
    • Hou, X., Xu, S., Maitland-Toolan, K. A., Sato, K. et al., SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J. Biol. Chem. 2008, 283, 20015-20026.
    • (2008) J. Biol. Chem. , vol.283 , pp. 20015-20026
    • Hou, X.1    Xu, S.2    Maitland-Toolan, K.A.3    Sato, K.4
  • 240
    • 84861712572 scopus 로고    scopus 로고
    • SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
    • Jung, T. W., Lee, K. T., Lee, M. W., Ka, K. H., SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150. Biochem. Biophys. Res. Commun. 2012, 422, 229-232.
    • (2012) Biochem. Biophys. Res. Commun. , vol.422 , pp. 229-232
    • Jung, T.W.1    Lee, K.T.2    Lee, M.W.3    Ka, K.H.4
  • 241
    • 31144478126 scopus 로고    scopus 로고
    • Therapeutic potential of curcumin in non-alcoholic steatohepatitis
    • Shapiro, H., Bruck, R., Therapeutic potential of curcumin in non-alcoholic steatohepatitis. Nutr. Res. Rev. 2005, 18, 212-221.
    • (2005) Nutr. Res. Rev. , vol.18 , pp. 212-221
    • Shapiro, H.1    Bruck, R.2
  • 242
    • 84865197360 scopus 로고    scopus 로고
    • Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis
    • Kuo, J. J., Chang, H. H., Tsai, T. H., Lee, T. Y., Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis. Int. J. Mol. Med. 2012, 30, 673-679.
    • (2012) Int. J. Mol. Med. , vol.30 , pp. 673-679
    • Kuo, J.J.1    Chang, H.H.2    Tsai, T.H.3    Lee, T.Y.4
  • 243
    • 84877269694 scopus 로고    scopus 로고
    • The effects of curcumin derivative on experimental steatohepatitis
    • Zeng, C. H., Zeng, P., Deng, Y. H., Shen, N. et al., The effects of curcumin derivative on experimental steatohepatitis. Zhonghua Gan. Zang. Bing. Za Zhi 2011, 19, 454-459.
    • (2011) Zhonghua Gan. Zang. Bing. Za Zhi , vol.19 , pp. 454-459
    • Zeng, C.H.1    Zeng, P.2    Deng, Y.H.3    Shen, N.4
  • 244
    • 46349088791 scopus 로고    scopus 로고
    • Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity
    • Weisberg, S. P., Leibel, R., Tortoriello, D. V., Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008, 149, 3549-3558.
    • (2008) Endocrinology , vol.149 , pp. 3549-3558
    • Weisberg, S.P.1    Leibel, R.2    Tortoriello, D.V.3
  • 245
    • 69249228674 scopus 로고    scopus 로고
    • Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha
    • Ramirez-Tortosa, M. C., Ramirez-Tortosa, C. L., Mesa, M. D., Granados, S. et al., Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic. Biol. Med. 2009, 47, 924-931.
    • (2009) Free Radic. Biol. Med. , vol.47 , pp. 924-931
    • Ramirez-Tortosa, M.C.1    Ramirez-Tortosa, C.L.2    Mesa, M.D.3    Granados, S.4
  • 246
    • 48349120605 scopus 로고    scopus 로고
    • Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study
    • Qu, X. B., Zhao, S. P., Xu, J., Dong, L. N., Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study. Zhong. Xi. Yi. Jie. He. Xue. Bao. 2008, 6, 711-715.
    • (2008) Zhong. Xi. Yi. Jie. He. Xue. Bao. , vol.6 , pp. 711-715
    • Qu, X.B.1    Zhao, S.P.2    Xu, J.3    Dong, L.N.4
  • 247
    • 84856086373 scopus 로고    scopus 로고
    • Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-alpha-induced oxidative stress, colitis and hepatotoxicity in mice
    • Mouzaoui, S., Rahim, I., Djerdjouri, B., Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-alpha-induced oxidative stress, colitis and hepatotoxicity in mice. Int. Immunopharmacol. 2012, 12, 302-311.
    • (2012) Int. Immunopharmacol. , vol.12 , pp. 302-311
    • Mouzaoui, S.1    Rahim, I.2    Djerdjouri, B.3
  • 248
    • 84865158452 scopus 로고    scopus 로고
    • Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis
    • Kuo, J. J., Chang, H. H., Tsai, T. H., Lee, T. Y., Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis. Int. J. Mol. Med. 2012, 30, 643-649.
    • (2012) Int. J. Mol. Med. , vol.30 , pp. 643-649
    • Kuo, J.J.1    Chang, H.H.2    Tsai, T.H.3    Lee, T.Y.4
  • 249
    • 84879844301 scopus 로고    scopus 로고
    • Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytes
    • Messner, D. J., Rhieu, B. H., Kowdley, K. V., Iron overload causes oxidative stress and impaired insulin signaling in AML-12 hepatocytes. Dig. Dis. Sci. 2013, 58, 1899-1908.
    • (2013) Dig. Dis. Sci. , vol.58 , pp. 1899-1908
    • Messner, D.J.1    Rhieu, B.H.2    Kowdley, K.V.3
  • 250
    • 70549101361 scopus 로고    scopus 로고
    • Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress
    • Lin, J., Zheng, S., Chen, A., Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress. Lab. Invest. 2009, 89, 1397-1409.
    • (2009) Lab. Invest. , vol.89 , pp. 1397-1409
    • Lin, J.1    Zheng, S.2    Chen, A.3
  • 251
    • 79651474066 scopus 로고    scopus 로고
    • Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2
    • Lin, J., Chen, A., Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2. Mol. Cell. Endocrinol. 2011, 333, 160-171.
    • (2011) Mol. Cell. Endocrinol. , vol.333 , pp. 160-171
    • Lin, J.1    Chen, A.2
  • 252
    • 77958546345 scopus 로고    scopus 로고
    • Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase
    • Tang, Y., Chen, A., Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase. Br. J. Pharmacol. 2010, 161, 1137-1149.
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 1137-1149
    • Tang, Y.1    Chen, A.2
  • 253
    • 77956030796 scopus 로고    scopus 로고
    • Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids
    • Tang, Y., Chen, A., Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. Endocrinology 2010, 151, 4168-4177.
    • (2010) Endocrinology , vol.151 , pp. 4168-4177
    • Tang, Y.1    Chen, A.2
  • 254
    • 70350662973 scopus 로고    scopus 로고
    • Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1
    • Kang, Q., Chen, A., Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1. Lab. Invest. 2009, 89, 1275-1290.
    • (2009) Lab. Invest. , vol.89 , pp. 1275-1290
    • Kang, Q.1    Chen, A.2
  • 255
    • 70350341460 scopus 로고    scopus 로고
    • Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells
    • Kang, Q., Chen, A., Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells. Br. J. Pharmacol. 2009, 157, 1354-1367.
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 1354-1367
    • Kang, Q.1    Chen, A.2
  • 256
    • 4644332608 scopus 로고    scopus 로고
    • Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
    • Garcea, G., Jones, D. J., Singh, R., Dennison, A. R. et al., Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br. J. Cancer 2004, 90, 1011-1015.
    • (2004) Br. J. Cancer , vol.90 , pp. 1011-1015
    • Garcea, G.1    Jones, D.J.2    Singh, R.3    Dennison, A.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.