Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: In vitro and in vivo experiments in rodents

Metabolism: Clinical and Experimental

Volumn 61, Issue 3, 2012, Pages 424-433

  Kang, Wonyoung ^a   Hong, Hyun Ju ^a   Guan, Jian ^b   Kim, Dong Geon ^a   Yang, Eun Jin ^b   Koh, Gwanpyo ^b   Park, Doekbae ^b   Han, Chang Hoon ^a   Lee, Young Jae ^a   Lee, Dae Ho ^b  

^a Jeju National University   (South Korea)

^b Jeju National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; GLUCOSE; GLYCOGEN; I KAPPA B ALPHA; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; NITRIC OXIDE SYNTHASE; PROTEIN KINASE; PROTEIN KINASE B; RESVERATROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET INDUCED OBESE; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOCYTES; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DIETARY FATS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STILBENES;

EID: 84857501565     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.08.003     Document Type: Article

References (39)

1. G.J. Soleas, E.P. Diamandis, and D.M. Goldberg The world of resveratrol Adv Exp Med Biol 492 2001 159 182 (Pubitemid 32682074)
2. K.J. Pearson, J.A. Baur, and K.N. Lewis Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span Cell Metab 8 2008 157 168
3. J.A. Baur, K.J. Pearson, and N.L. Price Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 2006 337 342 (Pubitemid 44764104)
4. K. Szkudelska, and T. Szkudelski Resveratrol, obesity and diabetes Eur J Pharmacol 635 2010 1 8
5. M. Lagouge, C. Argmann, and Z. Gerhart-Hines Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha Cell 127 2006 1109 1122 (Pubitemid 44894520)
6. B. Fauconneau, P. Waffo-Teguo, and F. Huguet Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests Life Sci 61 1997 2103 2110 (Pubitemid 27478837)
7. C.R. PaceAsciak, O. Rounova, and S.E. Hahn Wines and grape juices as modulators of platelet aggregation in healthy human subjects Clin Chim Acta 246 1996 163 182 (Pubitemid 26094547)
8. T.C. Hsieh, G. Juan, and Z. Darzynkiewicz Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2 Cancer Res 59 1999 2596 2601 (Pubitemid 29269105)
9. E.N. Frankel, A.L. Waterhouse, and J.E. Kinsella Inhibition of human LDL oxidation by resveratrol Lancet 341 1993 1103 1104 (Pubitemid 23114451)
10. S.H. Tsai, S.Y. Lin-Shiau, and J.K. Lin Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol Br J Pharmacol 126 1999 673 680
11. F. Yeung, J.E. Hoberg, and C.S. Ramsey Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase EMBO J 23 2004 2369 2380 (Pubitemid 38954844)
12. K. Szkudelska, L. Nogowski, and T. Szkudelski Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes J Steroid Biochem Mol Biol 113 2009 17 24
13. S. Frojdo, D. Cozzone, and H. Vidal Resveratrol is a class IA phosphoinositide 3-kinase inhibitor Biochem J 406 2007 511 518 (Pubitemid 47425457)
14. J. Zhang Resveratrol inhibits insulin responses in a SirT1-independent pathway Biochem J 397 2006 519 527 (Pubitemid 44187510)
15. S. Frojdo, C. Durand, and L. Molin Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1 Mol Cell Endocrinol 335 2011 166 176
16. C. Sun, F. Zhang, and X. Ge SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B Cell Metab 6 2007 307 319 (Pubitemid 47468091)
17. J.C. Milne, P.D. Lambert, and S. Schenk Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes Nature 450 2007 712 716 (Pubitemid 350207685)
18. M.C. Aubin, C. Lajoie, and R. Clement Female rats fed a high-fat diet were associated with vascular dysfunction and cardiac fibrosis in the absence of overt obesity and hyperlipidemia: therapeutic potential of resveratrol J Pharmacol Exp Ther 325 2008 961 968 (Pubitemid 351724317)
19. T.A. Pedersen, O. Bereshchenko, and S. Garcia-Silva Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo Embo J 26 2007 1081 1093
20. E. Sexton, C. Van Themsche, and K. LeBlanc Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells Mol Cancer 5 2006 45
21. A.C. Faber, F.J. Dufort, and D. Blair Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas Biochem Pharmacol 72 2006 1246 1256 (Pubitemid 44572191)
22. L.J. Egan, and M. Toruner NF-kappaB signaling: pros and cons of altering NF-kappaB as a therapeutic approach Ann N Y Acad Sci 1072 2006 114 122 (Pubitemid 44448447)
23. A. Oeckinghaus, and S. Ghosh The NF-kappaB family of transcription factors and its regulation Cold Spring Harb Perspect Biol 1 2009 a000034
24. J. Hirosumi, G. Tuncman, and L. Chang A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336 (Pubitemid 35398190)
25. G. Solinas, C. Vilcu, and J.G. Neels JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity Cell Metab 6 2007 386 397 (Pubitemid 350012000)
26. M.C. Arkan, A.L. Hevener, and F.R. Greten IKK-beta links inflammation to obesity-induced insulin resistance Nat Med 11 2005 191 198 (Pubitemid 40321355)
27. S.E. Shoelson, J. Lee, and A.B. Goldfine Inflammation and insulin resistance J Clin Investig 116 2006 1793 1801 (Pubitemid 44033299)
28. R.S. Hundal, K.F. Petersen, and A.B. Mayerson Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes J Clin Investig 109 2002 1321 1326 (Pubitemid 34546896)
29. S. Mariotto, Y. Suzuki, and T. Persichini Cross-talk between NO and arachidonic acid in inflammation Curr Med Chem 14 2007 1940 1944 (Pubitemid 47209105)
30. A.M. Gonzales, and R.A. Orlando Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes Nutr Metab (Lond) 5 2008 17
31. M. Holmes-McNary, and A.S. Baldwin Jr Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase Cancer Res 60 2000 3477 3483 (Pubitemid 30482167)
32. K.T. Howitz, K.J. Bitterman, and H.Y. Cohen Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 425 2003 191 196 (Pubitemid 37150899)
33. Y.H. Feng, J.P. Zou, and X.Y. Li Effects of resveratrol and ethanol on production of pro-inflammatory factors from endotoxin activated murine macrophages Acta Pharmacol Sin 23 2002 1002 1006
34. D.I. Cho, N.Y. Koo, and W.J. Chung Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: structural requirements and mechanism of action Life Sci 71 2002 2071 2082
35. N.B. Ruderman, X.J. Xu, and L. Nelson AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab 298 2010 E751 E760
36. L. Rivera, R. Moron, and A. Zarzuelo Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats Biochem Pharmacol 77 2009 1053 1063
37. J. Yang, X. Kong, and M.E. Martins-Santos Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha J Biol Chem 284 2009 27042 27053
38. D. Chen, J. Bruno, and E. Easlon Tissue-specific regulation of SIRT1 by calorie restriction Genes Dev 22 2008 1753 1757 (Pubitemid 351915500)
39. C. Bonnard, A. Durand, and H. Vidal Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice Diabetes Metab 34 2008 52 61