메뉴 건너뛰기




Volumn 23, Issue 4, 2012, Pages 349-360

Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1

Author keywords

Anthocyanin; C Jun N terminal kinase; Forkhead box O1; Hepatic steatosis; Inflammation; Insulin resistance

Indexed keywords

CYANIDIN 3 GLUCOSIDE; GLUCOSE; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR ALPHA;

EID: 84858290692     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.12.013     Document Type: Article
Times cited : (209)

References (45)
  • 1
    • 77249132284 scopus 로고    scopus 로고
    • Adipose tissue inflammation in obesity and metabolic syndrome
    • Nishimura S., Manabe I., Nagai R. Adipose tissue inflammation in obesity and metabolic syndrome. Discov Med 2009, 8:55-60.
    • (2009) Discov Med , vol.8 , pp. 55-60
    • Nishimura, S.1    Manabe, I.2    Nagai, R.3
  • 2
    • 41849113834 scopus 로고    scopus 로고
    • Role of adipocytokines in obesity-associated insulin resistance
    • Zou C., Shao J. Role of adipocytokines in obesity-associated insulin resistance. J Nutr Biochem 2008, 19:277-286.
    • (2008) J Nutr Biochem , vol.19 , pp. 277-286
    • Zou, C.1    Shao, J.2
  • 5
    • 33845444076 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model
    • Alwayn I.P., Andersson C., Lee S., Arsenault D.A., Bistrian B.R., Gura K.M., et al. Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. Am J Physiol Gastrointest Liver Physiol 2006, 291:G1011-G1019.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291
    • Alwayn, I.P.1    Andersson, C.2    Lee, S.3    Arsenault, D.A.4    Bistrian, B.R.5    Gura, K.M.6
  • 6
    • 10844246291 scopus 로고    scopus 로고
    • Decreased plasma adiponectin concentrations are closely associated with nonalcoholic hepatic steatosis in obese individuals
    • Targher G., Bertolini L., Scala L., Poli F., Zenari L., Falezza G. Decreased plasma adiponectin concentrations are closely associated with nonalcoholic hepatic steatosis in obese individuals. Clin Endocrinol (Oxf) 2004, 61:700-703.
    • (2004) Clin Endocrinol (Oxf) , vol.61 , pp. 700-703
    • Targher, G.1    Bertolini, L.2    Scala, L.3    Poli, F.4    Zenari, L.5    Falezza, G.6
  • 7
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • Nakae J., Biggs W.H., Kitamura T., Cavenee W.K., Wright C.V., Arden K.C., et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet 2002, 32:245-253.
    • (2002) Nat Genet , vol.32 , pp. 245-253
    • Nakae, J.1    Biggs, W.H.2    Kitamura, T.3    Cavenee, W.K.4    Wright, C.V.5    Arden, K.C.6
  • 8
    • 34548349302 scopus 로고    scopus 로고
    • Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    • Matsumoto M., Pocai A., Rossetti L., Depinho R.A., Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab 2007, 6:208-216.
    • (2007) Cell Metab , vol.6 , pp. 208-216
    • Matsumoto, M.1    Pocai, A.2    Rossetti, L.3    Depinho, R.A.4    Accili, D.5
  • 9
    • 0037237279 scopus 로고    scopus 로고
    • The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    • Nakae J., Kitamura T., Kitamura Y., Biggs W.H., Arden K.C., Accili D. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell 2003, 4:119-129.
    • (2003) Dev Cell , vol.4 , pp. 119-129
    • Nakae, J.1    Kitamura, T.2    Kitamura, Y.3    Biggs, W.H.4    Arden, K.C.5    Accili, D.6
  • 10
    • 11244320393 scopus 로고    scopus 로고
    • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
    • Essers M.A., Weijzen S., de Vries-Smits A.M., Saarloos I., de Ruiter N.D., Bos J.L., et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 2004, 23:4802-4812.
    • (2004) EMBO J , vol.23 , pp. 4802-4812
    • Essers, M.A.1    Weijzen, S.2    de Vries-Smits, A.M.3    Saarloos, I.4    de Ruiter, N.D.5    Bos, J.L.6
  • 11
    • 77749273738 scopus 로고    scopus 로고
    • Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress
    • Shen B., Chao L., Chao J. Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress. Am J Physiol Heart Circ Physiol 2010, 298:H1048-H1054.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Shen, B.1    Chao, L.2    Chao, J.3
  • 12
    • 1642464560 scopus 로고    scopus 로고
    • Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms
    • Zhao X., Gan L., Pan H., Kan D., Majeski M., Adam S.A., et al. Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. Biochem J 2004, 378:839-849.
    • (2004) Biochem J , vol.378 , pp. 839-849
    • Zhao, X.1    Gan, L.2    Pan, H.3    Kan, D.4    Majeski, M.5    Adam, S.A.6
  • 13
    • 33748312093 scopus 로고    scopus 로고
    • Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
    • Matsumoto M., Han S., Kitamura T., Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 2006, 116:2464-2472.
    • (2006) J Clin Invest , vol.116 , pp. 2464-2472
    • Matsumoto, M.1    Han, S.2    Kitamura, T.3    Accili, D.4
  • 14
    • 40949164735 scopus 로고    scopus 로고
    • Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure
    • Nakae J., Cao Y., Oki M., Orba Y., Sawa H., Kiyonari H., et al. Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure. Diabetes 2008, 57:563-576.
    • (2008) Diabetes , vol.57 , pp. 563-576
    • Nakae, J.1    Cao, Y.2    Oki, M.3    Orba, Y.4    Sawa, H.5    Kiyonari, H.6
  • 15
    • 66649115077 scopus 로고    scopus 로고
    • FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue
    • Kim J.J., Li P., Huntley J., Chang J.P., Arden K.C., Olefsky J.M. FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue. Diabetes 2009, 58:1275-1282.
    • (2009) Diabetes , vol.58 , pp. 1275-1282
    • Kim, J.J.1    Li, P.2    Huntley, J.3    Chang, J.P.4    Arden, K.C.5    Olefsky, J.M.6
  • 16
    • 57049104503 scopus 로고    scopus 로고
    • Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes
    • Ito Y., Daitoku H., Fukamizu A. Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes. Biochem Biophys Res Commun 2009, 378:290-295.
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 290-295
    • Ito, Y.1    Daitoku, H.2    Fukamizu, A.3
  • 18
    • 79957867318 scopus 로고    scopus 로고
    • Anthocyanins: natural colorants with health-promoting properties
    • He J., Giusti M.M. Anthocyanins: natural colorants with health-promoting properties. Annu Rev Food Sci Technol 2010, 1:163-187.
    • (2010) Annu Rev Food Sci Technol , vol.1 , pp. 163-187
    • He, J.1    Giusti, M.M.2
  • 19
    • 47649120373 scopus 로고    scopus 로고
    • Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver × receptor alpha activation in THP-1 macrophages
    • Wang Q., Xia M., Liu C., Guo H., Ye Q., Hu Y., et al. Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver × receptor alpha activation in THP-1 macrophages. Life Sci 2008, 83:176-184.
    • (2008) Life Sci , vol.83 , pp. 176-184
    • Wang, Q.1    Xia, M.2    Liu, C.3    Guo, H.4    Ye, Q.5    Hu, Y.6
  • 20
    • 33847028751 scopus 로고    scopus 로고
    • Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution
    • Xia M., Ling W., Zhu H., Wang Q., Ma J., Hou M., et al. Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution. Arterioscler Thromb Vasc Biol 2007, 27:519-524.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 519-524
    • Xia, M.1    Ling, W.2    Zhu, H.3    Wang, Q.4    Ma, J.5    Hou, M.6
  • 21
    • 39749188825 scopus 로고    scopus 로고
    • 2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation
    • 2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation. Biochem Pharmacol 2008, 75:1393-1401.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1393-1401
    • Guo, H.1    Ling, W.2    Wang, Q.3    Liu, C.4    Hu, Y.5    Xia, M.6
  • 22
    • 0037592261 scopus 로고    scopus 로고
    • Dietary cyanidin 3-O-beta-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice
    • Tsuda T., Horio F., Uchida K., Aoki H., Osawa T. Dietary cyanidin 3-O-beta-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 2003, 133:2125-2130.
    • (2003) J Nutr , vol.133 , pp. 2125-2130
    • Tsuda, T.1    Horio, F.2    Uchida, K.3    Aoki, H.4    Osawa, T.5
  • 23
    • 33847287825 scopus 로고    scopus 로고
    • Effect of anthocyanin-rich extract from black rice (Oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats
    • Guo H., Ling W., Wang Q., Liu C., Hu Y., Xia M., et al. Effect of anthocyanin-rich extract from black rice (Oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats. Plant Foods Hum Nutr 2007, 62:1-6.
    • (2007) Plant Foods Hum Nutr , vol.62 , pp. 1-6
    • Guo, H.1    Ling, W.2    Wang, Q.3    Liu, C.4    Hu, Y.5    Xia, M.6
  • 24
    • 31044449046 scopus 로고    scopus 로고
    • Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas)
    • Jayaprakasam B., Olson L.K., Schutzki R.E., Tai M.H., Nair M.G. Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 2006, 54:243-248.
    • (2006) J Agric Food Chem , vol.54 , pp. 243-248
    • Jayaprakasam, B.1    Olson, L.K.2    Schutzki, R.E.3    Tai, M.H.4    Nair, M.G.5
  • 25
    • 77249168728 scopus 로고    scopus 로고
    • Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice
    • Takikawa M., Inoue S., Horio F., Tsuda T. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J Nutr 2010, 140:527-533.
    • (2010) J Nutr , vol.140 , pp. 527-533
    • Takikawa, M.1    Inoue, S.2    Horio, F.3    Tsuda, T.4
  • 26
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
    • Reeves P.G., Nielsen F.H., Fahey G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993, 123:1939-1951.
    • (1993) J Nutr , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey, G.C.3
  • 27
    • 0031737373 scopus 로고    scopus 로고
    • Correct homeostasis model assessment (HOMA) evaluation uses the computer program
    • Levy J.C., Matthews D.R., Hermans M.P. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998, 21:2191-2192.
    • (1998) Diabetes Care , vol.21 , pp. 2191-2192
    • Levy, J.C.1    Matthews, D.R.2    Hermans, M.P.3
  • 28
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 29
    • 0037962069 scopus 로고    scopus 로고
    • Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation
    • Alessi M.C., Bastelica D., Mavri A., Morange P., Berthet B., Grino M., et al. Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation. Arterioscler Thromb Vasc Biol 2003, 23:1262-1268.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1262-1268
    • Alessi, M.C.1    Bastelica, D.2    Mavri, A.3    Morange, P.4    Berthet, B.5    Grino, M.6
  • 30
    • 0033956846 scopus 로고    scopus 로고
    • The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding
    • Kobayashi K., Forte T.M., Taniguchi S., Ishida B.Y., Oka K., Chan L. The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism 2000, 49:22-31.
    • (2000) Metabolism , vol.49 , pp. 22-31
    • Kobayashi, K.1    Forte, T.M.2    Taniguchi, S.3    Ishida, B.Y.4    Oka, K.5    Chan, L.6
  • 31
    • 27444445460 scopus 로고    scopus 로고
    • JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes
    • Nguyen M.T., Satoh H., Favelyukis S., Babendure J.L., Imamura T., Sbodio J.I., et al. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem 2005, 280:35361-35371.
    • (2005) J Biol Chem , vol.280 , pp. 35361-35371
    • Nguyen, M.T.1    Satoh, H.2    Favelyukis, S.3    Babendure, J.L.4    Imamura, T.5    Sbodio, J.I.6
  • 33
    • 57649221326 scopus 로고    scopus 로고
    • Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation
    • Xia M., Ling W., Zhu H., Ma J., Wang Q., Hou M., et al. Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation. Atherosclerosis 2009, 202:41-47.
    • (2009) Atherosclerosis , vol.202 , pp. 41-47
    • Xia, M.1    Ling, W.2    Zhu, H.3    Ma, J.4    Wang, Q.5    Hou, M.6
  • 34
    • 0141706357 scopus 로고    scopus 로고
    • Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
    • Matsuzaki H., Daitoku H., Hatta M., Tanaka K., Fukamizu A. Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A 2003, 100:11285-11290.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 11285-11290
    • Matsuzaki, H.1    Daitoku, H.2    Hatta, M.3    Tanaka, K.4    Fukamizu, A.5
  • 35
    • 33750588944 scopus 로고    scopus 로고
    • Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice
    • Aoyama H., Daitoku H., Fukamizu A. Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice. Int J Mol Med 2006, 18:433-439.
    • (2006) Int J Mol Med , vol.18 , pp. 433-439
    • Aoyama, H.1    Daitoku, H.2    Fukamizu, A.3
  • 36
    • 33744515637 scopus 로고    scopus 로고
    • FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression
    • Zhang W., Patil S., Chauhan B., Guo S., Powell D.R., Le J., et al. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem 2006, 281:10105-10117.
    • (2006) J Biol Chem , vol.281 , pp. 10105-10117
    • Zhang, W.1    Patil, S.2    Chauhan, B.3    Guo, S.4    Powell, D.R.5    Le, J.6
  • 37
    • 51349128983 scopus 로고    scopus 로고
    • Anthocyanins and their role in cancer prevention
    • Wang L.S., Stoner G.D. Anthocyanins and their role in cancer prevention. Cancer Lett 2008, 269:281-290.
    • (2008) Cancer Lett , vol.269 , pp. 281-290
    • Wang, L.S.1    Stoner, G.D.2
  • 38
    • 35348964129 scopus 로고    scopus 로고
    • Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice
    • Sasaki R., Nishimura N., Hoshino H., Isa Y., Kadowaki M., Ichi T., et al. Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol 2007, 74:1619-1627.
    • (2007) Biochem Pharmacol , vol.74 , pp. 1619-1627
    • Sasaki, R.1    Nishimura, N.2    Hoshino, H.3    Isa, Y.4    Kadowaki, M.5    Ichi, T.6
  • 39
    • 70349574630 scopus 로고    scopus 로고
    • Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects
    • Qin Y., Xia M., Ma J., Hao Y., Liu J., Mou H., et al. Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am J Clin Nutr 2009, 90:485-492.
    • (2009) Am J Clin Nutr , vol.90 , pp. 485-492
    • Qin, Y.1    Xia, M.2    Ma, J.3    Hao, Y.4    Liu, J.5    Mou, H.6
  • 40
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H., Tateya S., Tamori Y., Kotani K., Hiasa K., Kitazawa R., et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006, 116:1494-1505.
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3    Kotani, K.4    Hiasa, K.5    Kitazawa, R.6
  • 41
    • 2342428466 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner
    • de Alvaro C., Teruel T., Hernandez R., Lorenzo M. Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 2004, 279:17070-17078.
    • (2004) J Biol Chem , vol.279 , pp. 17070-17078
    • de Alvaro, C.1    Teruel, T.2    Hernandez, R.3    Lorenzo, M.4
  • 42
    • 70350515679 scopus 로고    scopus 로고
    • Regular tart cherry intake alters abdominal adiposity, adipose gene transcription, and inflammation in obesity-prone rats fed a high fat diet
    • Seymour E.M., Lewis S.K., Urcuyo-Llanes D.E., Tanone I.I., Kirakosyan A., Kaufman P.B., et al. Regular tart cherry intake alters abdominal adiposity, adipose gene transcription, and inflammation in obesity-prone rats fed a high fat diet. J Med Food 2009, 12:935-942.
    • (2009) J Med Food , vol.12 , pp. 935-942
    • Seymour, E.M.1    Lewis, S.K.2    Urcuyo-Llanes, D.E.3    Tanone, I.I.4    Kirakosyan, A.5    Kaufman, P.B.6
  • 43
    • 33846004396 scopus 로고    scopus 로고
    • Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
    • Lumeng C.N., Deyoung S.M., Saltiel A.R. Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab 2007, 292:E166-E174.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Lumeng, C.N.1    Deyoung, S.M.2    Saltiel, A.R.3
  • 44
    • 66149102890 scopus 로고    scopus 로고
    • The role of FOXO in the regulation of metabolism
    • Gross D.N., Wan M., Birnbaum M.J. The role of FOXO in the regulation of metabolism. Curr Diab Rep 2009, 9:208-214.
    • (2009) Curr Diab Rep , vol.9 , pp. 208-214
    • Gross, D.N.1    Wan, M.2    Birnbaum, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.