-
2
-
-
30944466037
-
TGF-beta as a T cell regulator in colitis and colon cancer
-
DOI 10.1016/j.cytogfr.2005.09.004, PII S1359610105001085
-
Becker C, Fantini MC, Neurath MF (2006) TGF-β as a T cell regulator in colitis and colon cancer. Cytokine Growth Factor Rev 17:97-106 (Pubitemid 43117519)
-
(2006)
Cytokine and Growth Factor Reviews
, vol.17
, Issue.1-2
, pp. 97-106
-
-
Becker, C.1
Fantini, M.C.2
Neurath, M.F.3
-
3
-
-
41649118421
-
Transforming growth factor β controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin
-
DOI 10.1091/mbc.E07-09-0967
-
Biname F, Lassus P, Hibner U (2008) Transforming growth factor β controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin.Mol Biol Cell 19:945-956 (Pubitemid 351481810)
-
(2008)
Molecular Biology of the Cell
, vol.19
, Issue.3
, pp. 945-956
-
-
Biname, F.1
Lassus, P.2
Hibner, U.3
-
4
-
-
77956958497
-
Regulation of liver regeneration by growth factors and cytokines
-
Bohm F, Kohler UA, Speicher T, Werner S (2010) Regulation of liver regeneration by growth factors and cytokines. EMBO Mol Med 2:294-305
-
(2010)
EMBO Mol Med
, vol.2
, pp. 294-305
-
-
Bohm, F.1
Kohler, U.A.2
Speicher, T.3
Werner, S.4
-
5
-
-
0025403070
-
Transforming growth factor β1 in liver carcinogenesis: Messenger RNA expression and growth effects
-
Braun L, Gruppuso P, Mikumo R, Fausto N (1990) Transforming growth factor β1 in liver carcinogenesis: messenger RNA expression and growth effects. Cell Growth Differ 1:103-111
-
(1990)
Cell Growth Differ
, vol.1
, pp. 103-111
-
-
Braun, L.1
Gruppuso, P.2
Mikumo, R.3
Fausto, N.4
-
6
-
-
32044437966
-
Anti-TGF-β strategies for the treatment of chronic liver disease
-
DOI 10.1097/01.alc.0000189284.98684.22
-
Breitkopf K, Haas S, Wiercinska E, Singer MV, Dooley S (2005) Anti-TGF-β strategies for the treatment of chronic liver disease. Alcohol Clin Exp Res 29:121S-131S (Pubitemid 43194338)
-
(2005)
Alcoholism: Clinical and Experimental Research
, vol.29
, Issue.11 SUPPL.
-
-
Breitkopf, K.1
Haas, S.2
Wiercinska, E.3
Singer, M.V.4
Dooley, S.5
-
7
-
-
31944433741
-
TGF-β/Smad signaling in the injured liver
-
Breitkopf K, Godoy P, Ciuclan L, Singer MV, Dooley S (2006) TGF-β/Smad signaling in the injured liver. Z Gastroenterol 44:57-66
-
(2006)
Z Gastroenterol
, vol.44
, pp. 57-66
-
-
Breitkopf, K.1
Godoy, P.2
Ciuclan, L.3
Singer, M.V.4
Dooley, S.5
-
8
-
-
79955123951
-
Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
-
Chu AS, Diaz R, Hui JJ, Yanger K, Zong Y, Alpini G, Stanger BZ, Wells RG (2011) Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology 53:1685-1695
-
(2011)
Hepatology
, vol.53
, pp. 1685-1695
-
-
Chu, A.S.1
Diaz, R.2
Hui, J.J.3
Yanger, K.4
Zong, Y.5
Alpini, G.6
Stanger, B.Z.7
Wells, R.G.8
-
9
-
-
10744230440
-
Inhibitory effect of a soluble transforming growth factor β type II receptor on the activation of rat hepatic stellate cells in primary culture
-
DOI 10.1016/S0168-8278(03)00216-2
-
Cui X, Shimizu I, Lu G, Itonaga M, Inoue H, Shono M, Tamaki K, Fukuno H, Ueno H, Ito S (2003) Inhibitory effect of a soluble transforming growth factor β type II receptor on the activation of rat hepatic stellate cells in primary culture. J Hepatol 39:731-737 (Pubitemid 37372181)
-
(2003)
Journal of Hepatology
, vol.39
, Issue.5
, pp. 731-737
-
-
Cui, X.1
Shimizu, I.2
Lu, G.3
Itonaga, M.4
Inoue, H.5
Shono, M.6
Tamaki, K.7
Fukuno, H.8
Ueno, H.9
Ito, S.10
-
10
-
-
3042732409
-
Transgenic analysis of scleroderma: Understanding key pathogenic events in vivo
-
DOI 10.1016/j.autrev.2003.10.003, PII S1568997203001319
-
Denton CP, Abraham DJ (2004) Transgenic analysis of scleroderma: understanding key pathogenic events in vivo. Autoimmun Rev 3:285-293 (Pubitemid 38887624)
-
(2004)
Autoimmunity Reviews
, vol.3
, Issue.4
, pp. 285-293
-
-
Denton, C.P.1
Abraham, D.J.2
-
11
-
-
35448991324
-
Extracellular control of TGFβ signalling in vascular development and disease
-
DOI 10.1038/nrm2262, PII NRM2262
-
Dijke P ten, Arthur HM (2007) Extracellular control of TGFβ signalling in vascular development and disease. Nat Rev Mol Cell Biol 8:857-869 (Pubitemid 47622560)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.11
, pp. 857-869
-
-
Ten, D.P.1
Arthur, H.M.2
-
12
-
-
0034094837
-
Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts
-
Dooley S, Delvoux B, Lahme B, Mangasser-Stephan K, Gressner AM (2000) Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 31:1094-1106 (Pubitemid 30233234)
-
(2000)
Hepatology
, vol.31
, Issue.5
, pp. 1094-1106
-
-
Dooley, S.1
Delvoux, B.2
Lahme, B.3
Mangasser-Stephan, K.4
Gressner, A.M.5
-
13
-
-
0035958625
-
Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts: TGFβ signal transduction during transdifferentiation of hepatic stellate cells
-
DOI 10.1016/S0014-5793(01)02656-4, PII S0014579301026564
-
Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, Ten DP, Gressner AM (2001a) Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFβ signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett 502:4-10 (Pubitemid 32722050)
-
(2001)
FEBS Letters
, vol.502
, Issue.1-2
, pp. 4-10
-
-
Dooley, S.1
Delvoux, B.2
Streckert, M.3
Bonzel, L.4
Stopa, M.5
Ten, D.P.6
Gressner, A.M.7
-
14
-
-
0034804663
-
Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts
-
DOI 10.1006/bbrc.2001.4811
-
Dooley S, Streckert M, Delvoux B, Gressner AM (2001b) Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts. Biochem Biophys Res Commun 283:554-562 (Pubitemid 32917925)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.283
, Issue.3
, pp. 554-562
-
-
Dooley, S.1
Streckert, M.2
Delvoux, B.3
Gressner, A.M.4
-
15
-
-
0037716406
-
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats
-
DOI 10.1016/S0016-5085(03)00666-8
-
Dooley S, Hamzavi J, Breitkopf K, Wiercinska E, Said HM, Lorenzen J, Dijke ten P, Gressner AM (2003) Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 125:178-191 (Pubitemid 36799118)
-
(2003)
Gastroenterology
, vol.125
, Issue.1
, pp. 178-191
-
-
Dooley, S.1
Hamzavi, J.2
Breitkopf, K.3
Wiercinska, E.4
Said, H.M.5
Lorenzen, J.6
Ten, D.P.7
Gressner, A.M.8
-
16
-
-
48549084059
-
Hepatocyte-specific Smad7 expression attenuates TGF-β-mediated fibrogenesis and protects against liver damage
-
Dooley S, Hamzavi J, Ciuclan L, Godoy P, Ilkavets I, Ehnert S, Ueberham E, Gebhardt R, Kanzler S, Geier A, Breitkopf K, Weng H, Mertens PR (2008) Hepatocyte-specific Smad7 expression attenuates TGF-β-mediated fibrogenesis and protects against liver damage. Gastroenterology 135:642-659
-
(2008)
Gastroenterology
, vol.135
, pp. 642-659
-
-
Dooley, S.1
Hamzavi, J.2
Ciuclan, L.3
Godoy, P.4
Ilkavets, I.5
Ehnert, S.6
Ueberham, E.7
Gebhardt, R.8
Kanzler, S.9
Geier, A.10
Breitkopf, K.11
Weng, H.12
Mertens, P.R.13
-
17
-
-
67650932419
-
Hypotheses on the role of transforming growth factor-β in the onset and progression of hepatocellular carcinoma
-
Dooley S, Weng H, Mertens PR (2009) Hypotheses on the role of transforming growth factor-β in the onset and progression of hepatocellular carcinoma. Dig Dis 27:93-101
-
(2009)
Dig Dis
, vol.27
, pp. 93-101
-
-
Dooley, S.1
Weng, H.2
Mertens, P.R.3
-
19
-
-
10744230462
-
A synthetic peptide from transforming growth factor β type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury
-
DOI 10.1016/S1043-4666(03)00101-7
-
Ezquerro IJ, Lasarte JJ, Dotor J, Castilla-Cortazar I, Bustos M, Penuelas I, Blanco G, Rodriguez C, Lechuga MC, Greenwel P, Rojkind M, Prieto J, Borras-Cuesta F (2003) A synthetic peptide from transforming growth factor β type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine 22:12-20 (Pubitemid 37222298)
-
(2003)
Cytokine
, vol.22
, Issue.1-2
, pp. 12-20
-
-
Ezquerro, I.-J.1
Lasarte, J.-J.2
Dotor, J.3
Castilla-Cortazar, I.4
Bustos, M.5
Penuelas, I.6
Blanco, G.7
Rodriguez, C.8
Lechuga, M.D.C.G.9
Greenwel, P.10
Rojkind, M.11
Prieto, J.12
Borras-Cuesta, F.13
-
20
-
-
0022837544
-
Proto-oncogene expression and growth factors during liver regeneration
-
Fausto N, Mead JE, Braun L, Thompson NL, Panzica M, Goyette M, Bell GI, Shank PR (1986) Proto-oncogene expression and growth factors during liver regeneration. Symp Fundam Cancer Res 39:69-86
-
(1986)
Symp Fundam Cancer Res
, vol.39
, pp. 69-86
-
-
Fausto, N.1
Mead, J.E.2
Braun, L.3
Thompson, N.L.4
Panzica, M.5
Goyette, M.6
Bell, G.I.7
Shank, P.R.8
-
21
-
-
0036124599
-
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation
-
Flanders KC, Sullivan CD, Fujii M, Sowers A, Anzano MA, Arabshahi A, Major C, Deng C, Russo A, Mitchell JB, Roberts AB (2002) Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol 160:1057-1068 (Pubitemid 34224592)
-
(2002)
American Journal of Pathology
, vol.160
, Issue.3
, pp. 1057-1068
-
-
Flanders, K.C.1
Sullivan, C.D.2
Fujii, M.3
Sowers, A.4
Anzano, M.A.5
Arabshahi, A.6
Major, C.7
Deng, C.8
Russo, A.9
Mitchell, J.B.10
Roberts, A.B.11
-
22
-
-
0034723290
-
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
-
Friedman SL (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275:2247-2250
-
(2000)
J Biol Chem
, vol.275
, pp. 2247-2250
-
-
Friedman, S.L.1
-
23
-
-
42949163491
-
Mechanisms of hepatic fibrogenesis
-
Friedman SL (2008) Mechanisms of hepatic fibrogenesis. Gastroenterology 134:1655-1669
-
(2008)
Gastroenterology
, vol.134
, pp. 1655-1669
-
-
Friedman, S.L.1
-
24
-
-
77955472579
-
Evolving challenges in hepatic fibrosis
-
Friedman SL (2010) Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol 7:425-436
-
(2010)
Nat Rev Gastroenterol Hepatol
, vol.7
, pp. 425-436
-
-
Friedman, S.L.1
-
25
-
-
0141866937
-
p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts
-
DOI 10.1053/jhep.2003.50384
-
Furukawa F, Matsuzaki K, Mori S, Tahashi Y, Yoshida K, Sugano Y, Yamagata H, Matsushita M, Seki T, Inagaki Y, Nishizawa M, Fujisawa J, Inoue K (2003) p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Hepatology 38:879-889 (Pubitemid 37221671)
-
(2003)
Hepatology
, vol.38
, Issue.4
, pp. 879-889
-
-
Furukawa, F.1
Matsuzaki, K.2
Mori, S.3
Tahashi, Y.4
Yoshida, K.5
Sugano, Y.6
Yamagata, H.7
Matsushita, M.8
Seki, T.9
Inagaki, Y.10
Nishizawa, M.11
Fujisawa, J.12
Inoue, K.13
-
26
-
-
0033607304
-
In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis
-
DOI 10.1073/pnas.96.22.12719
-
George J, Roulot D, Koteliansky VE, Bissell DM (1999) In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: a potential new therapy for hepatic fibrosis. Proc Natl Acad Sci USA 96:12719-12724 (Pubitemid 29513569)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.22
, pp. 12719-12724
-
-
George, J.1
Roulot, D.2
Koteliansky, V.E.3
Bissell, D.M.4
-
27
-
-
79251633236
-
Inhibiting TGF-β signaling in hepatocellular carcinoma
-
Giannelli G, Mazzocca A, Fransvea E, Lahn M, Antonaci S (2011) Inhibiting TGF-β signaling in hepatocellular carcinoma. Biochim Biophys Acta 1815:214-223
-
(2011)
Biochim Biophys Acta
, vol.1815
, pp. 214-223
-
-
Giannelli, G.1
Mazzocca, A.2
Fransvea, E.3
Lahn, M.4
Antonaci, S.5
-
28
-
-
67650999336
-
Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β-induced apoptosis
-
Godoy P, Hengstler JG, Ilkavets I, Meyer C, Bachmann A, Muller A, Tuschl G, Mueller SO, Dooley S (2009) Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β-induced apoptosis. Hepatology 49:2031-2043
-
(2009)
Hepatology
, vol.49
, pp. 2031-2043
-
-
Godoy, P.1
Hengstler, J.G.2
Ilkavets, I.3
Meyer, C.4
Bachmann, A.5
Muller, A.6
Tuschl, G.7
Mueller, S.O.8
Dooley, S.9
-
29
-
-
0037087507
-
Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: Steps towards invasiveness
-
Gotzmann J, Huber H, Thallinger C, Wolschek M, Jansen B, Schulte-Hermann R, Beug H, Mikulits W (2002) Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: steps towards invasiveness. J Cell Sci 115:1189-1202 (Pubitemid 34272483)
-
(2002)
Journal of Cell Science
, vol.115
, Issue.6
, pp. 1189-1202
-
-
Gotzmann, J.1
Huber, H.2
Thallinger, C.3
Wolschek, M.4
Jansen, B.5
Schulte-Hermann, R.6
Beug, H.7
Mikulits, W.8
-
30
-
-
48949084865
-
Connective tissue growth factor: A fibrogenic master switch in fibrotic liver diseases
-
Gressner OA, Gressner AM (2008) Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases. Liver Int 28:1065-1079
-
(2008)
Liver Int
, vol.28
, pp. 1065-1079
-
-
Gressner, O.A.1
Gressner, A.M.2
-
31
-
-
79960364782
-
Exploring anti TGF-β therapies in cancer and fibrosis
-
Hawinkels LJ, Dijke P ten (2011) Exploring anti TGF-β therapies in cancer and fibrosis. Growth Factors 29:140-152
-
(2011)
Growth Factors
, vol.29
, pp. 140-152
-
-
Hawinkels, L.J.1
Ten Dijke, P.2
-
32
-
-
0022254636
-
DNA synthesis in rat hepatocytes: Inhibition by a platelet factor and stimulation by an endogenous factor
-
DOI 10.1002/jcp.1041250111
-
Hayashi I, Carr BI (1985) DNA synthesis in rat hepatocytes: inhibition by a platelet factor and stimulation by an endogenous factor. J Cell Physiol 125:82-90 (Pubitemid 15012072)
-
(1985)
Journal of Cellular Physiology
, vol.125
, Issue.1
, pp. 82-90
-
-
Hayashi, I.1
Carr, B.I.2
-
33
-
-
0032586690
-
The role of TGFβ1 in initiating hepatic stellate cell activation in vivo
-
DOI 10.1016/S0168-8278(99)80010-5
-
Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER, Brenner DA (1999) The role of TGFβ1 in initiating hepatic stellate cell activation in vivo. J Hepatol 30:77-87 (Pubitemid 29023655)
-
(1999)
Journal of Hepatology
, vol.30
, Issue.1
, pp. 77-87
-
-
Hellerbrand, C.1
Stefanovic, B.2
Giordano, F.3
Burchardt, E.R.4
Brenner, D.A.5
-
34
-
-
0030934411
-
Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis
-
Herbst H, Wege T, Milani S, Pellegrini G, Orzechowski HD, Bechstein WO, Neuhaus P, Gressner AM, Schuppan D (1997) Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis. Am J Pathol 150:1647-1659 (Pubitemid 27193813)
-
(1997)
American Journal of Pathology
, vol.150
, Issue.5
, pp. 1647-1659
-
-
Herbst, H.1
Wege, T.2
Milani, S.3
Pellegrini, G.4
Orzechowski, H.-D.5
Bechstein, W.O.6
Neuhaus, P.7
Gressner, A.M.8
Schuppan, D.9
-
36
-
-
77349092851
-
Molecular classification and novel targets in hepatocellular carcinoma: Recent advancements
-
Hoshida Y, Toffanin S, Lachenmayer A, Villanueva A, Minguez B, Llovet JM (2010) Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. Semin Liver Dis 30:35-51
-
(2010)
Semin Liver Dis
, vol.30
, pp. 35-51
-
-
Hoshida, Y.1
Toffanin, S.2
Lachenmayer, A.3
Villanueva, A.4
Minguez, B.5
Llovet, J.M.6
-
37
-
-
0024582143
-
Introduction of a Ha-ras oncogene into rat liver epithelial cells and parenchymal hepatocytes confers resistance to the growth inhibitory effects of TGF-β
-
Houck KA, Michalopoulos GK, Strom SC (1989) Introduction of a Ha-ras oncogene into rat liver epithelial cells and parenchymal hepatocytes confers resistance to the growth inhibitory effects of TGF-β. Oncogene 4:19-25 (Pubitemid 19085064)
-
(1989)
Oncogene
, vol.4
, Issue.1
, pp. 19-25
-
-
Houck, K.A.1
Michalopoulos, G.K.2
Strom, S.C.3
-
38
-
-
0035884192
-
Heterozygous mice for the transforming growth factor-β type II receptor gene have increased susceptibility to hepatocellular carcinogenesis
-
Im YH, Kim HT, Kim IY, Factor VM, Hahm KB, Anzano M, Jang JJ, Flanders K, Haines DC, Thorgeirsson SS, Sizeland A, Kim SJ (2001) Heterozygous mice for the transforming growth factor-β type II receptor gene have increased susceptibility to hepatocellular carcinogenesis. Cancer Res 61:6665-6668 (Pubitemid 32896482)
-
(2001)
Cancer Research
, vol.61
, Issue.18
, pp. 6665-6668
-
-
Im, Y.-H.1
Heung, T.K.2
Isaac, Y.K.3
Factor, V.M.4
Hahm, K.-B.5
Anzano, M.6
Jang, J.-J.7
Flanders, K.8
Haines, D.C.9
Thorgeirsson, S.S.10
Sizeland, A.11
Kim, S.-J.12
-
39
-
-
0028978771
-
Regulation of the α2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver
-
Inagaki Y, Truter S, Greenwel P, Rojkind M, Unoura M, Kobayashi K, Ramirez F (1995) Regulation of the α2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver. Hepatology 22:573-579
-
(1995)
Hepatology
, vol.22
, pp. 573-579
-
-
Inagaki, Y.1
Truter, S.2
Greenwel, P.3
Rojkind, M.4
Unoura, M.5
Kobayashi, K.6
Ramirez, F.7
-
40
-
-
0035120166
-
Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells
-
DOI 10.1002/1097-4652(2001)9999:9999<00::AID-JCP1059>3.0.CO;2-S
-
Inagaki Y, Mamura M, Kanamaru Y, Greenwel P, Nemoto T, Takehara K, ten Dijke P, Nakao A (2001a) Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol 187:117-123 (Pubitemid 32195252)
-
(2001)
Journal of Cellular Physiology
, vol.187
, Issue.1
, pp. 117-123
-
-
Inagaki, Y.1
Mamura, M.2
Kanamaru, Y.3
Greenwel, P.4
Nemoto, T.5
Takehara, K.6
Dijke, P.T.7
Nakao, A.8
-
41
-
-
0035844276
-
Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2(I) collagen gene transcription
-
Inagaki Y, Nemoto T, Nakao A, Dijke P ten, Kobayashi K, Takehara K, Greenwel P (2001b) Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2(I) collagen gene transcription. J Biol Chem 276:16573-16579
-
(2001)
J Biol Chem
, vol.276
, pp. 16573-16579
-
-
Inagaki, Y.1
Nemoto, T.2
Nakao, A.3
Ten Dijke, P.4
Kobayashi, K.5
Takehara, K.6
Greenwel, P.7
-
42
-
-
33847363203
-
Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
-
Iredale JP (2007) Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Investig 117:539-548
-
(2007)
J Clin Investig
, vol.117
, pp. 539-548
-
-
Iredale, J.P.1
-
43
-
-
25444515482
-
Targeting TGFβ signaling for cancer therapy
-
Iyer S, Wang ZG, Akhtari M, Zhao W, Seth P (2005) Targeting TGFβ signaling for cancer therapy. Cancer Biol Ther 4:261-266 (Pubitemid 41357481)
-
(2005)
Cancer Biology and Therapy
, vol.4
, Issue.3
, pp. 261-266
-
-
Iyer, S.1
Wang, Z.-G.2
Akhtari, M.3
Zhao, W.4
Seth, P.5
-
44
-
-
0036144377
-
TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase
-
DOI 10.1038/ncb731
-
Jang CW, Chen CH, Chen CC, Chen JY, Su YH, Chen RH (2002) TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase. Nat Cell Biol 4:51-58 (Pubitemid 34071980)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.1
, pp. 51-58
-
-
Jang, C.-W.1
Chen, C.-H.2
Chen, C.-C.3
Chen, J.-Y.4
Su, Y.-H.5
Chen, R.-H.6
-
45
-
-
31044448265
-
Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-β1-induced extracellular matrix expression
-
DOI 10.1124/mol.105.017483
-
Jinnin M, Ihn H, Tamaki K (2006) Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-β1-induced extracellular matrix expression. Mol Pharmacol 69:597-607 (Pubitemid 43121957)
-
(2006)
Molecular Pharmacology
, vol.69
, Issue.2
, pp. 597-607
-
-
Jinnin, M.1
Ihn, H.2
Tamaki, K.3
-
46
-
-
34547599359
-
Transforming growth factor-β1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
-
DOI 10.1074/jbc.M700998200
-
Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E, Koteish A (2007) Transforming growth factor-β1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 282:22089-22101 (Pubitemid 47195788)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.30
, pp. 22089-22101
-
-
Kaimori, A.1
Potter, J.2
Kaimori, J.-Y.3
Wang, C.4
Mezey, E.5
Koteish, A.6
-
47
-
-
0033109090
-
TGF-β1 in liver fibrosis: An inducible transgenic mouse model to study liver fibrogenesis
-
Kanzler S, Lohse AW, Keil A, Henninger J, Dienes HP, Schirmacher P, Rose-John S, Buschenfelde KH zum, Blessing M (1999) TGF-β1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis. Am J Physiol 276:G1059-G1068 (Pubitemid 29214121)
-
(1999)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.276
, Issue.4
-
-
Kanzler, S.1
Lohse, A.W.2
Keil, A.3
Henninger, J.4
Dienes, H.P.5
Schirmacher, P.6
Rose-John, S.7
Meyer, Z.B.K.H.8
Blessing, M.9
-
48
-
-
0035899396
-
Hepatocellular expression of a dominant-negative mutant TGF-β type II receptor accelerates chemically induced hepatocarcinogenesis
-
DOI 10.1038/sj.onc.1204544
-
Kanzler S, Meyer E, Lohse AW, Schirmacher P, Henninger J, Galle PR, Blessing M (2001) Hepatocellular expression of a dominant-negative mutant TGF-β type II receptor accelerates chemically induced hepatocarcinogenesis. Oncogene 20:5015-5024 (Pubitemid 32769791)
-
(2001)
Oncogene
, vol.20
, Issue.36
, pp. 5015-5024
-
-
Kanzler, S.1
Meyer, E.2
Lohse, A.W.3
Schirmacher, P.4
Henninger, J.5
Galle, P.R.6
Blessing, M.7
-
49
-
-
0029841151
-
Gene expression and regulation of plasminogen activator inhibitor type I in hepatic stellate cells of rat liver
-
Knittel T, Fellmer P, Ramadori G (1996) Gene expression and regulation of plasminogen activator inhibitor type I in hepatic stellate cells of rat liver. Gastroenterology 111:745-754 (Pubitemid 26293241)
-
(1996)
Gastroenterology
, vol.111
, Issue.3
, pp. 745-754
-
-
Knittel, T.1
Fellmer, P.2
Ramadori, G.3
-
51
-
-
67650501166
-
Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice
-
Latella G, Vetuschi A, Sferra R, Catitti V, D'Angelo A, Zanninelli G, Flanders KC, Gaudio E (2009) Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice. Liver Int 29:997-1009
-
(2009)
Liver Int
, vol.29
, pp. 997-1009
-
-
Latella, G.1
Vetuschi, A.2
Sferra, R.3
Catitti, V.4
D'Angelo, A.5
Zanninelli, G.6
Flanders, K.C.7
Gaudio, E.8
-
52
-
-
33745577640
-
Comparative and integrative functional genomics of HCC
-
Lee JS, Thorgeirsson SS (2006) Comparative and integrative functional genomics of HCC. Oncogene 25:3801-3809
-
(2006)
Oncogene
, vol.25
, pp. 3801-3809
-
-
Lee, J.S.1
Thorgeirsson, S.S.2
-
53
-
-
0037837754
-
Smads 2 and 3 are differentially activated by transforming growth factor-β (TGF-β) in quiescent and activated hepatic stellate cells: Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent
-
DOI 10.1074/jbc.M207728200
-
Liu C, Gaca MD, Swenson ES, Vellucci VF, Reiss M, Wells RG (2003) Smads 2 and 3 are differentially activated by transforming growth factor-β (TGF-β) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem 278:11721-11728 (Pubitemid 36792736)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.13
, pp. 11721-11728
-
-
Liu, C.1
Gaca, M.D.A.2
Swenson, E.S.3
Vellucci, V.F.4
Reiss, M.5
Wells, R.G.6
-
54
-
-
32244440927
-
Smad3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-β1 in cultured rat hepatic stellate cells
-
DOI 10.1007/s11095-005-9043-5
-
Liu X, Wang W, Hu H, Tang N, Zhang C, Liang W, Wang M (2006) Smad3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-β1 in cultured rat hepatic stellate cells. Pharm Res 23:82-89 (Pubitemid 43214663)
-
(2006)
Pharmaceutical Research
, vol.23
, Issue.1
, pp. 82-89
-
-
Liu, X.1
Wang, W.2
Hu, H.3
Tang, N.4
Zhang, C.5
Liang, W.6
Wang, M.7
-
55
-
-
63849191286
-
Modulation of TGF-β signaling during progression of chronic liver diseases
-
Matsuzaki K (2009) Modulation of TGF-β signaling during progression of chronic liver diseases. Front Biosci 14:2923-2934
-
(2009)
Front Biosci
, vol.14
, pp. 2923-2934
-
-
Matsuzaki, K.1
-
56
-
-
34347232205
-
Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor β signaling, promoting cirrhosis and hepatocellular carcinoma
-
DOI 10.1002/hep.21672
-
Matsuzaki K, Murata M, Yoshida K, Sekimoto G, Uemura Y, Sakaida N, Kaibori M, Kamiyama Y, Nishizawa M, Fujisawa J, Okazaki K, Seki T (2007) Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor β signaling, promoting cirrhosis and hepatocellular carcinoma. Hepatology 46:48-57 (Pubitemid 47171920)
-
(2007)
Hepatology
, vol.46
, Issue.1
, pp. 48-57
-
-
Matsuzaki, K.1
Murata, M.2
Yoshida, K.3
Sekimoto, G.4
Uemura, Y.5
Sakaida, N.6
Kaibori, M.7
Kamiyama, Y.8
Nishizawa, M.9
Fujisawa, J.10
Okazaki, K.11
Seki, T.12
-
57
-
-
0041342109
-
Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
-
DOI 10.1167/iovs.02-0978
-
Mead AL, Wong TT, Cordeiro MF, Anderson IK, Khaw PT (2003) Evaluation of anti-TGF-β2 antibody as a new postoperative antiscarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci 44:3394-3401 (Pubitemid 36909776)
-
(2003)
Investigative Ophthalmology and Visual Science
, vol.44
, Issue.8
, pp. 3394-3401
-
-
Mead, A.L.1
Wong, T.T.L.2
Cordeiro, M.F.3
Anderson, I.K.4
Khaw, P.T.5
-
60
-
-
78651447817
-
Liver regeneration: Alternative epithelial pathways
-
Michalopoulos GK (2011) Liver regeneration: alternative epithelial pathways. Int J Biochem Cell Biol 43:173-179
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 173-179
-
-
Michalopoulos, G.K.1
-
61
-
-
58949088366
-
Liver stem cells and hepatocellular carcinoma
-
Mishra L, Banker T, Murray J, Byers S, Thenappan A, He AR, Shetty K, Johnson L, Reddy EP (2009) Liver stem cells and hepatocellular carcinoma. Hepatology 49:318-329
-
(2009)
Hepatology
, vol.49
, pp. 318-329
-
-
Mishra, L.1
Banker, T.2
Murray, J.3
Byers, S.4
Thenappan, A.5
He, A.R.6
Shetty, K.7
Johnson, L.8
Reddy, E.P.9
-
62
-
-
0032499789
-
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
-
DOI 10.1073/pnas.95.12.6733
-
Moustakas A, Kardassis D (1998) Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc Natl Acad Sci USA 95:6733-6738 (Pubitemid 28278049)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.12
, pp. 6733-6738
-
-
Moustakas, A.1
Kardassis, D.2
-
63
-
-
22744452759
-
Involvement of EGF receptor and c-Src in the survival signals induced by TGF-β1 in hepatocytes
-
DOI 10.1038/sj.onc.1208664
-
Murillo MM, del Castillo G, Sanchez A, Fernandez M, Fabregat I (2005) Involvement of EGF receptor and c-Src in the survival signals induced by TGF-β1 in hepatocytes. Oncogene 24:4580-4587 (Pubitemid 41032621)
-
(2005)
Oncogene
, vol.24
, Issue.28
, pp. 4580-4587
-
-
Murillo, M.M.1
Del, C.G.2
Sanchez, A.3
Fernandez, M.4
Fabregat, I.5
-
64
-
-
0022297755
-
Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture
-
Nakamura T, Tomita Y, Hirai R, Yamaoka K, Kaji K, Ichihara A (1985) Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture. Biochem Biophys Res Commun 133:1042-1050 (Pubitemid 16142884)
-
(1985)
Biochemical and Biophysical Research Communications
, vol.133
, Issue.3
, pp. 1042-1050
-
-
Nakamura, T.1
Tomita, Y.2
Hirai, R.3
-
65
-
-
0033854016
-
Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine- treated rats
-
Nakamura T, Sakata R, Ueno T, Sata M, Ueno H (2000) Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology 32:247-255 (Pubitemid 30614657)
-
(2000)
Hepatology
, vol.32
, Issue.2
, pp. 247-255
-
-
Nakamura, T.1
Sakata, R.2
Ueno, T.3
Sata, M.4
Ueno, H.5
-
66
-
-
0032719815
-
Transient gene transfer and expression of Smad7 prevents bleomycin- induced lung fibrosis in mice
-
Nakao A, Fujii M, Matsumura R, Kumano K, Saito Y, Miyazono K, Iwamoto I (1999) Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 104:5-11 (Pubitemid 29534339)
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.1
, pp. 5-11
-
-
Nakao, A.1
Fujii, M.2
Matsumura, R.3
Kumano, K.4
Saito, Y.5
Miyazono, K.6
Iwamoto, I.7
-
67
-
-
0025301290
-
Cellular distribution of transforming growth factor-β1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis
-
Nakatsukasa H, Nagy P, Evarts RP, Hsia CC, Marsden E, Thorgeirsson SS (1990) Cellular distribution of transforming growth factor-β1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest 85:1833-1843 (Pubitemid 20192957)
-
(1990)
Journal of Clinical Investigation
, vol.85
, Issue.6
, pp. 1833-1843
-
-
Nakatsukasa, H.1
Nagy, P.2
Evarts, R.P.3
Hsia, C.-C.4
Marsden, E.5
Thorgeirsson, S.S.6
-
68
-
-
0035124049
-
Rat hepatic stellate cells contribute to the acute-phase response with increased expression of α1 (I) and α1 (IV) collagens, tissue inhibitor of metalloproteinase-1, and matrix-metalloproteinase-2 messenger RNAs
-
DOI 10.1053/jhep.2001.22520
-
Nieto N, Dominguez-Rosales JA, Fontana L, Salazar A, Armendariz-Borunda J, Greenwel P, Rojkind M (2001) Rat hepatic stellate cells contribute to the acute-phase response with increased expression of α1(I) and α1(IV) collagens, tissue inhibitor of metalloproteinase-1, and matrix- metalloproteinase-2 messenger RNAs. Hepatology 33:597-607 (Pubitemid 32185222)
-
(2001)
Hepatology
, vol.33
, Issue.3
, pp. 597-607
-
-
Nieto, N.1
Dominguez-Rosales, J.A.2
Fontana, L.3
Salazar, A.4
Armendariz-Borunda, J.5
Greenwel, P.6
Rojkind, M.7
-
69
-
-
0025830047
-
Effect of transforming growth factor β on cell death of cultured rat hepatocytes
-
Oberhammer F, Bursch W, Parzefall W, Breit P, Erber E, Stadler M, Schulte-Hermann R (1991) Effect of transforming growth factor β on cell death of cultured rat hepatocytes. Cancer Res 51:2478-2485
-
(1991)
Cancer Res
, vol.51
, pp. 2478-2485
-
-
Oberhammer, F.1
Bursch, W.2
Parzefall, W.3
Breit, P.4
Erber, E.5
Stadler, M.6
Schulte-Hermann, R.7
-
71
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74-108 (Pubitemid 40372904)
-
(2005)
Ca-A Cancer Journal for Clinicians
, vol.55
, Issue.2
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
72
-
-
34848891816
-
Targeting transforming growth factor-β signaling
-
DOI 10.1097/CCO.0b013e3282f0ad0e, PII 0000162220071100000007
-
Pennison M, Pasche B (2007) Targeting transforming growth factor-β signaling. Curr Opin Oncol 19:579-585 (Pubitemid 47508864)
-
(2007)
Current Opinion in Oncology
, vol.19
, Issue.6
, pp. 579-585
-
-
Pennison, M.1
Pasche, B.2
-
73
-
-
0034906821
-
TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
-
DOI 10.1038/35087019
-
Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA (2001) TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol 3:708-714 (Pubitemid 32734248)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.8
, pp. 708-714
-
-
Perlman, R.1
Schiemann, W.P.2
Brooks, M.W.3
Lodish, H.F.4
Weinberg, R.A.5
-
74
-
-
40049099699
-
Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis
-
DOI 10.1038/sj.ki.5002717, PII 5002717
-
Petersen M, Thorikay M, Deckers M, Dinther M van, Grygielko ET, Gellibert F, Gouville AC de, Huet S, Dijke P ten, Laping NJ (2008) Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis. Kidney Int 73:705-715 (Pubitemid 351323246)
-
(2008)
Kidney International
, vol.73
, Issue.6
, pp. 705-715
-
-
Petersen, M.1
Thorikay, M.2
Deckers, M.3
Van Dinther, M.4
Grygielko, E.T.5
Gellibert, F.6
De Gouville, A.C.7
Huet, S.8
Ten, D.P.9
Laping, N.J.10
-
75
-
-
77956148273
-
Epithelial-to-mesenchymal transition in liver fibrosis: Dead or alive?
-
Popov Y, Schuppan D (2010) Epithelial-to-mesenchymal transition in liver fibrosis: dead or alive? Gastroenterology 139:722-725
-
(2010)
Gastroenterology
, vol.139
, pp. 722-725
-
-
Popov, Y.1
Schuppan, D.2
-
76
-
-
0033515099
-
Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
-
DOI 10.1073/pnas.96.5.2345
-
Qi Z, Atsuchi N, Ooshima A, Takeshita A, Ueno H (1999) Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci USA 96:2345-2349 (Pubitemid 29117917)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.5
, pp. 2345-2349
-
-
Qi, Z.1
Atsuchi, N.2
Ooshima, A.3
Takeshita, A.4
Ueno, H.5
-
77
-
-
53249137795
-
TGFβ-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2
-
Ramesh S, Qi XJ, Wildey GM, Robinson J, Molkentin J, Letterio J, Howe PH (2008) TGFβ-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO Rep 9:990-997
-
(2008)
EMBO Rep
, vol.9
, pp. 990-997
-
-
Ramesh, S.1
Qi, X.J.2
Wildey, G.M.3
Robinson, J.4
Molkentin, J.5
Letterio, J.6
Howe, P.H.7
-
78
-
-
0031058607
-
Transforming growth factor-β1 induces activation of ras, raf-1, MEK and MAPK in rat hepatic stellate cells
-
DOI 10.1016/S0014-5793(97)00024-0, PII S0014579397000240
-
Reimann T, Hempel U, Krautwald S, Axmann A, Scheibe R, Seidel D, Wenzel KW (1997) Transforming growth factor-β1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells. FEBS Lett 403:57-60 (Pubitemid 27079809)
-
(1997)
FEBS Letters
, vol.403
, Issue.1
, pp. 57-60
-
-
Reimann, T.1
Hempel, U.2
Krautwald, S.3
Axmann, A.4
Scheibe, R.5
Seidel, D.6
Wenzel, K.-W.7
-
79
-
-
77952573691
-
Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis
-
Rombouts K, Marra F (2010) Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis. Dig Dis 28:229-235
-
(2010)
Dig Dis
, vol.28
, pp. 229-235
-
-
Rombouts, K.1
Marra, F.2
-
80
-
-
77349103260
-
Pathology of early hepatocellular carcinoma: Conventional and molecular diagnosis
-
Roskams T, Kojiro M (2010) Pathology of early hepatocellular carcinoma: conventional and molecular diagnosis. Semin Liver Dis 30:17-25
-
(2010)
Semin Liver Dis
, vol.30
, pp. 17-25
-
-
Roskams, T.1
Kojiro, M.2
-
81
-
-
0031948431
-
(Latent) transforming growth factor β in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells
-
DOI 10.1002/hep.510270416
-
Roth S, Michel K, Gressner AM (1998) (Latent) transforming growth factor β in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells. Hepatology 27:1003-1012 (Pubitemid 28160486)
-
(1998)
Hepatology
, vol.27
, Issue.4
, pp. 1003-1012
-
-
Roth, S.1
Michel, K.2
Gressner, A.M.3
-
82
-
-
79958050044
-
Hepatocyte-derived snail1 propagates liver fibrosis progression
-
Rowe RG, Lin Y, Shimizu-Hirota R, Hanada S, Neilson EG, Greenson JK, Weiss SJ (2011) Hepatocyte-derived snail1 propagates liver fibrosis progression. Mol Cell Biol 31:2392-2403
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2392-2403
-
-
Rowe, R.G.1
Lin, Y.2
Shimizu-Hirota, R.3
Hanada, S.4
Neilson, E.G.5
Greenson, J.K.6
Weiss, S.J.7
-
83
-
-
38449103630
-
Antisense therapeutics for tumor treatment: The TGF-β2 inhibitor AP 12009 in clinical development against malignant tumors
-
Schlingensiepen KH, Fischer-Blass B, Schmaus S, Ludwig S (2008) Antisense therapeutics for tumor treatment: the TGF-β2 inhibitor AP 12009 in clinical development against malignant tumors. Recent Results Cancer Res 177:137-150
-
(2008)
Recent Results Cancer Res
, vol.177
, pp. 137-150
-
-
Schlingensiepen, K.H.1
Fischer-Blass, B.2
Schmaus, S.3
Ludwig, S.4
-
84
-
-
0034956559
-
The role of Smad3 in mediating mouse hepatic stellate cell activation
-
DOI 10.1053/jhep.2001.25349
-
Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA, Brenner DA (2001) The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology 34:89-100 (Pubitemid 32591487)
-
(2001)
Hepatology
, vol.34
, Issue.1
, pp. 89-100
-
-
Schnabl, B.1
Kweon, Y.O.2
Frederick, J.P.3
Wang, X.-F.4
Rippe, R.A.5
Brenner, D.A.6
-
85
-
-
0027234350
-
Activin induces cell death in hepatocytes in vivo and in vitro
-
DOI 10.1016/0270-9139(93)90018-I
-
Schwall RH, Robbins K, Jardieu P, Chang L, Lai C, Terrell TG (1993) Activin induces cell death in hepatocytes in vivo and in vitro. Hepatology 18:347-356 (Pubitemid 23225106)
-
(1993)
Hepatology
, vol.18
, Issue.2
, pp. 347-356
-
-
Schwall, R.H.1
Robbins, K.2
Jardieu, P.3
Chang, L.4
Lai, C.5
Terrell, T.G.6
-
86
-
-
34547605248
-
Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling
-
Seyhan H, Hamzavi J, Wiercinska E, Gressner AM, Mertens PR, Kopp J, Horch RE, Breitkopf K, Dooley S (2006) Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling. J Cell Mol Med 10:922-932
-
(2006)
J Cell Mol Med
, vol.10
, pp. 922-932
-
-
Seyhan, H.1
Hamzavi, J.2
Wiercinska, E.3
Gressner, A.M.4
Mertens, P.R.5
Kopp, J.6
Horch, R.E.7
Breitkopf, K.8
Dooley, S.9
-
87
-
-
0034703087
-
Participation of Smad2, Smad3, and Smad4 in transforming growth factor β (TGF-β)-induced activation of Smad7: The TGF-β response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation
-
DOI 10.1074/jbc.M003282200
-
Stopa M, Anhuf D, Terstegen L, Gatsios P, Gressner AM, Dooley S (2000a) Participation of Smad2, Smad3, and Smad4 in transforming growth factor β (TGF-β)-induced activation of Smad7. The TGF-β response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation. J Biol Chem 275:29308-29317 (Pubitemid 32043801)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.38
, pp. 29308-29317
-
-
Stopa, M.1
Anhuf, D.2
Terstegen, L.3
Gatsios, P.4
Gressner, A.M.5
Dooley, S.6
-
88
-
-
0033955048
-
Genomic locus and promoter region of rat Smad7, an important antagonist of TGFβ signaling
-
DOI 10.1007/s003350010032
-
Stopa M, Benes V, Ansorge W, Gressner AM, Dooley S (2000b) Genomic locus and promoter region of rat Smad7, an important antagonist of TGFβ signaling. Mamm Genome 11:169-176 (Pubitemid 30054422)
-
(2000)
Mammalian Genome
, vol.11
, Issue.2
, pp. 169-176
-
-
Stopa, M.1
Benes, V.2
Ansorge, W.3
Gressner, A.M.4
Dooley, S.5
-
89
-
-
0023190821
-
Transforming growth factor β inhibits DNA synthesis in hepatocytes isolated from normal and regenerating rat liver
-
DOI 10.1016/0006-291X(87)91340-4
-
Strain AJ, Frazer A, Hill DJ, Milner RD (1987) Transforming growth factor β inhibits DNA synthesis in hepatocytes isolated from normal and regenerating rat liver. Biochem Biophys Res Commun 145:436-442 (Pubitemid 17088456)
-
(1987)
Biochemical and Biophysical Research Communications
, vol.145
, Issue.1
, pp. 436-442
-
-
Strain, A.J.1
Frazer, A.2
Hill, D.J.3
Milner, R.D.G.4
-
90
-
-
18244401140
-
Differential regulation of TGF-β signal in hepatic stellate cells between acute and chronic rat liver injury
-
DOI 10.1053/jhep.2002.30083
-
Tahashi Y, Matsuzaki K, Date M, Yoshida K, Furukawa F, Sugano Y, Matsushita M, Himeno Y, Inagaki Y, Inoue K (2002) Differential regulation of TGF-β signal in hepatic stellate cells between acute and chronic rat liver injury. Hepatology 35:49-61 (Pubitemid 34032543)
-
(2002)
Hepatology
, vol.35
, Issue.1
, pp. 49-61
-
-
Tahashi, Y.1
Matsuzaki, K.2
Date, M.3
Yoshida, K.4
Furukawa, F.5
Sugano, Y.6
Matsushita, M.7
Himeno, Y.8
Inagaki, Y.9
Inoue, K.10
-
91
-
-
70350007738
-
Transforming growth factor-β and Th17 responses in resistance to primary murine schistosomiasis mansoni
-
Tallima H, Salah M, Guirguis FR, El Ridi R (2009) Transforming growth factor-β and Th17 responses in resistance to primary murine schistosomiasis mansoni. Cytokine 48:239-245
-
(2009)
Cytokine
, vol.48
, pp. 239-245
-
-
Tallima, H.1
Salah, M.2
Guirguis, F.R.3
El Ridi, R.4
-
92
-
-
77950597707
-
Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
-
Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M, Brenner DA (2010) Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 51:1027-1036
-
(2010)
Hepatology
, vol.51
, pp. 1027-1036
-
-
Taura, K.1
Miura, K.2
Iwaisako, K.3
Osterreicher, C.H.4
Kodama, Y.5
Penz-Osterreicher, M.6
Brenner, D.A.7
-
93
-
-
0038374866
-
Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis
-
DOI 10.1053/jhep.2003.50196
-
Ueberham E, Low R, Ueberham U, Schonig K, Bujard H, Gebhardt R (2003) Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology 37:1067-1078 (Pubitemid 36538683)
-
(2003)
Hepatology
, vol.37
, Issue.5
, pp. 1067-1078
-
-
Ueberham, E.1
Low, R.2
Ueberham, U.3
Schonig, K.4
Bujard, H.5
Gebhardt, R.6
-
94
-
-
24344500807
-
Smad2 and Smad3 play different roles in rat hepatic stellate cell function and α-smooth muscle actin organization
-
DOI 10.1091/mbc.E05-02-0149
-
Uemura M, Swenson ES, Gaca MD, Giordano FJ, Reiss M, Wells RG (2005) Smad2 and Smad3 play different roles in rat hepatic stellate cell function and α-smooth muscle actin organization. Mol Biol Cell 16:4214-4224 (Pubitemid 41262890)
-
(2005)
Molecular Biology of the Cell
, vol.16
, Issue.9
, pp. 4214-4224
-
-
Uemura, M.1
Swenson, E.S.2
Gaca, M.D.A.3
Giordano, F.J.4
Reiss, M.5
Wells, R.G.6
-
95
-
-
0033984336
-
A soluble transforming growth factor β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats
-
DOI 10.1089/10430340050016139
-
Ueno H, Sakamoto T, Nakamura T, Qi Z, Astuchi N, Takeshita A, Shimizu K, Ohashi H (2000) A soluble transforming growth factor β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats. Hum Gene Ther 11:33-42 (Pubitemid 30044038)
-
(2000)
Human Gene Therapy
, vol.11
, Issue.1
, pp. 33-42
-
-
Ueno, H.1
Sakamoto, T.2
Nakamura, T.3
Qi, Z.4
Astuchi, N.5
Takeshita, A.6
Shimizu, K.7
Ohashi, H.8
-
96
-
-
33745428666
-
Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
-
DOI 10.1016/j.cmet.2006.05.011, PII S1550413106002026
-
Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, Wagner RA, Greaves DR, Murray PJ, Chawla A (2006) Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation. Cell Metab 4:13-24 (Pubitemid 43942258)
-
(2006)
Cell Metabolism
, vol.4
, Issue.1
, pp. 13-24
-
-
Vats, D.1
Mukundan, L.2
Odegaard, J.I.3
Zhang, L.4
Smith, K.L.5
Morel, C.R.6
Greaves, D.R.7
Murray, P.J.8
Chawla, A.9
-
97
-
-
79952277505
-
The incidence and epidemiology of hepatocellular carcinoma: A global and regional perspective
-
Venook AP, Papandreou C, Furuse J, Guevara LL de (2010) The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective. Oncologist 15(Suppl 4):5-13
-
(2010)
Oncologist
, vol.15
, Issue.SUPPL. 4
, pp. 5-13
-
-
Venook, A.P.1
Papandreou, C.2
Furuse, J.3
De Guevara, L.L.4
-
98
-
-
79951713169
-
Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease
-
Wang Q, Usinger W, Nichols B, Gray J, Xu L, Seeley TW, Brenner M, Guo G, Zhang W, Oliver N, Lin A, Yeowell D (2011) Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease. Fibrogenesis Tissue Repair 4:4
-
(2011)
Fibrogenesis Tissue Repair
, vol.4
, pp. 4
-
-
Wang, Q.1
Usinger, W.2
Nichols, B.3
Gray, J.4
Xu, L.5
Seeley, T.W.6
Brenner, M.7
Guo, G.8
Zhang, W.9
Oliver, N.10
Lin, A.11
Yeowell, D.12
-
99
-
-
79958222619
-
Chronic liver inflammation and hepatocellular carcinoma: Persistence matters
-
Weber A, Boege Y, Reisinger F, Heikenwalder M (2011) Chronic liver inflammation and hepatocellular carcinoma: persistence matters. Swiss Med Wkly 141:w13197
-
(2011)
Swiss Med Wkly
, vol.141
-
-
Weber, A.1
Boege, Y.2
Reisinger, F.3
Heikenwalder, M.4
-
100
-
-
36348932917
-
Profibrogenic transforming growth factor-β/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
-
DOI 10.1002/hep.21806
-
Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, Kanzler S, Heuchel R, Ueberham U, Gebhardt R, Breitkopf K, Dooley S (2007) Profibrogenic transforming growth factor-β/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology 46:1257-1270 (Pubitemid 350144790)
-
(2007)
Hepatology
, vol.46
, Issue.4
, pp. 1257-1270
-
-
Weng, H.-L.1
Ciuclan, L.2
Liu, Y.3
Hamzavi, J.4
Godoy, P.5
Gaitantzi, H.6
Kanzler, S.7
Heuchel, R.8
Ueberham, U.9
Gebhardt, R.10
Breitkopf, K.11
Dooley, S.12
-
101
-
-
77956627711
-
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
-
Whittaker S, Marais R, Zhu AX (2010) The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 29:4989-5005
-
(2010)
Oncogene
, vol.29
, pp. 4989-5005
-
-
Whittaker, S.1
Marais, R.2
Zhu, A.X.3
-
102
-
-
33646691720
-
Id1 Is a critical mediator in TGF-β-induced transdifferentiation of rat hepatic stellate cells
-
DOI 10.1002/hep.21135
-
Wiercinska E, Wickert L, Denecke B, Said HM, Hamzavi J, Gressner AM, Thorikay M, Dijke P ten, Mertens PR, Breitkopf K, Dooley S (2006) Id1 is a critical mediator in TGF-β-induced transdifferentiation of rat hepatic stellate cells. Hepatology 43:1032-1041 (Pubitemid 43738969)
-
(2006)
Hepatology
, vol.43
, Issue.5
, pp. 1032-1041
-
-
Wiercinska, E.1
Wickert, L.2
Denecke, B.3
Said, H.M.4
Hamzavi, J.5
Gressner, A.M.6
Thorikay, M.7
Ten, D.P.8
Mertens, P.R.9
Breitkopf, K.10
Dooley, S.11
-
103
-
-
3543107212
-
Fibrotic disease and the T(H)1/T(H)2 paradigm
-
Wynn TA (2004) Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol 4:583-594
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 583-594
-
-
Wynn, T.A.1
-
104
-
-
0027209278
-
Activin A: An autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes
-
Yasuda H, Mine T, Shibata H, Eto Y, Hasegawa Y, Takeuchi T, Asano S, Kojima I (1993) Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes. J Clin Invest 92:1491-1496 (Pubitemid 23273929)
-
(1993)
Journal of Clinical Investigation
, vol.92
, Issue.3
, pp. 1491-1496
-
-
Yasuda, H.1
Mine, T.2
Shibata, H.3
Eto, Y.4
Hasegawa, Y.5
Takeuchi, T.6
Asano, S.7
Kojima, I.8
-
105
-
-
0036242557
-
Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-β soluble receptor: Implications for antifibrotic therapy
-
DOI 10.1053/jhep.2002.32673
-
Yata Y, Gotwals P, Koteliansky V, Rockey DC (2002) Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-β soluble receptor: implications for antifibrotic therapy. Hepatology 35:1022-1030 (Pubitemid 34453999)
-
(2002)
Hepatology
, vol.35
, Issue.5
, pp. 1022-1030
-
-
Yata, Y.1
Gotwals, P.2
Koteliansky, V.3
Rockey, D.C.4
-
106
-
-
10444261212
-
Development of TGF-beta signalling inhibitors for cancer therapy
-
DOI 10.1038/nrd1580
-
Yingling JM, Blanchard KL, Sawyer JS (2004) Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov 3:1011-1022 (Pubitemid 39642364)
-
(2004)
Nature Reviews Drug Discovery
, vol.3
, Issue.12
, pp. 1011-1022
-
-
Yingling, J.M.1
Blanchard, K.L.2
Sawyer, J.S.3
-
107
-
-
20244376914
-
Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury
-
Yoshida K, Matsuzaki K, Mori S, Tahashi Y, Yamagata H, Furukawa F, Seki T, Nishizawa M, Fujisawa J, Okazaki K (2005) Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury. Am J Pathol 166:1029-1039 (Pubitemid 40524428)
-
(2005)
American Journal of Pathology
, vol.166
, Issue.4
, pp. 1029-1039
-
-
Yoshida, K.1
Matsuzaki, K.2
Mori, S.3
Tahashi, Y.4
Yamagata, H.5
Furukawa, F.6
Seki, T.7
Nishizawa, M.8
Fujisawa, J.9
Okazaki, K.10
-
108
-
-
34548145815
-
Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
-
DOI 10.1074/jbc.M700194200
-
Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R (2007) Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 282:23337-23347 (Pubitemid 47311952)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.32
, pp. 23337-23347
-
-
Zeisberg, M.1
Yang, C.2
Martino, M.3
Duncan, M.B.4
Rieder, F.5
Tanjore, H.6
Kalluri, R.7
-
109
-
-
61849183646
-
Targeting transforming growth factor-β signaling in liver metastasis of colon cancer
-
Zhang B, Halder SK, Zhang S, Datta PK (2009) Targeting transforming growth factor-β signaling in liver metastasis of colon cancer. Cancer Lett 277:114-120
-
(2009)
Cancer Lett
, vol.277
, pp. 114-120
-
-
Zhang, B.1
Halder, S.K.2
Zhang, S.3
Datta, P.K.4
|