Oxidized eicosapentaenoic acids more potently reduce LXRα-induced cellular triacylglycerol via suppression of SREBP-1c, PGC-1β and GPA than its intact form

Lipids in Health and Disease

Volumn 12, Issue 1, 2013, Pages

  Nanthirudjanar, Tharnath ^a   Furumoto, Hidehiro ^a   Hirata, Takashi ^a   Sugawara, Tatsuya ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Eicosapentaenoic acid; GPA; HepG2; LXR ; Oxidation; PGC 1 ; SREBP 1c; Triacylglycerol

Indexed keywords

GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; ICOSAPENTAENOIC ACID; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; OXIDIZED EICOSAPENTAENOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL FRACTIONATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; LIPID METABOLISM; LIPOGENESIS; LIQUID CHROMATOGRAPHY; LIVER CELL CARCINOMA; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ARACHIDONIC ACIDS; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; HEP G2 CELLS; HUMANS; LIPID METABOLISM; LIVER NEOPLASMS; ORPHAN NUCLEAR RECEPTORS; OXIDATION-REDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIGLYCERIDES;

EID: 84878884455     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-12-73     Document Type: Article

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