Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKC ζ

Journal of Lipid Research

Volumn 52, Issue 5, 2011, Pages 908-922

  Guo, Honghui ^a,b   Li, Dan ^a   Ling, Wenhua ^a   Feng, Xiang ^a   Xia, Min ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SHAOGUAN UNIVERSITY   (China)

Author keywords

Hepatocytes; Mitochondrial acyl CoA:glycerol sn 3 phosphate acyltransferase 1; Protein kinase C

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTHOCYANIN; CYANIDIN 3 GLUCOSIDE; GLUCOSE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; LIPID; PROTEIN KINASE C ZETA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE BETA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; FATTY ACID SYNTHESIS; FATTY LIVER; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; ISOLATED LIVER; LIPOGENESIS; MALE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTHOCYANINS; BLOTTING, WESTERN; ENZYME ACTIVATION; FATTY ACIDS; GLUCOSE; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; HEP G2 CELLS; HUMANS; LIVER; MICE; PROTEIN KINASE C; PROTON-TRANSLOCATING ATPASES; RNA INTERFERENCE;

EID: 79954989314     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M013375     Document Type: Article

References (45)

1. Flegal , K. M. , M. D. Carroll , C. L. Ogden , and L. R. Curtin . 2010 . Prevalence and trends in obesity among US adults. JAMA . 303 : 235-241 .
2. Gaemers , I. C. , and A. K. Groen . 2006 . New insights in the pathogenesis of non-alcoholic fatty liver disease. Curr. Opin. Lipidol. 17 : 268-273 . (Pubitemid 43786060)
3. Coleman , R. A. , and D. P. Lee . 2004 . Enzymes of triacylglycerol synthesis and their regulation. Prog. Lipid Res. 43 : 134-176 . (Pubitemid 37492937)
4. Lewin , T. M. , N. M. Schwerbrock , D. P. Lee , and R. A. Coleman . 2004 . Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria. J. Biol. Chem. 279 : 13488-13495 . (Pubitemid 38468873)
5. Dircks , L. K. 1997 . Mammalian mitochondrial glycerol-3-phosphate acyltransferase. Biochim. Biophys. Acta . 1348 : 17-26 . (Pubitemid 27467073)
6. Sul , H. S. , and D. Wang . 1998 . Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu. Rev. Nutr. 18 : 331-351 . (Pubitemid 28366871)
7. Lindén , D. , L. William-Olsson , M. Rhedin , A. K. Asztély , J. C. Clapham , and S. Schreyer . 2004 . Overexpression of mitochondrial GPAT in rat hepatocytes leads to decreased fatty acid oxidation and increased glycerolipid biosynthesis. J. Lipid Res. 45 : 1279-1288 . (Pubitemid 38802631)
8. Neschen , S. , K. Morino , L. E. Hammond , D. Zhang , Z. X. Liu , A. J. Romanelli , G. W. Cline , R. L. Pongratz , X. M. Zhang , C. S. Choi , et al . 2005 . Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab. 2 : 55-65 . (Pubitemid 43239825)
9. Wendel , A. A. , L. O. Li , Y. Li , G. W. Cline , G. I. Shulman , and R. A. Coleman . 2010 . Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity. Diabetes . 59 : 1321-1329 .
10. Williams , C. A. , and R. J. Grayer . 2004 . Anthocyanins and other fl avonoids. Nat. Prod. Rep. 21 : 539-573 . (Pubitemid 39187837)
11. Kong , J. M. , L. S. Chia , N. K. Goh , T. F. Chia , and R. Brouillard . 2003 . Analysis and biological activities of anthocyanins. Phytochemistry . 64 : 923-933 . (Pubitemid 37295344)
12. Xia , M. , W. H. Ling , J. Ma , D. D. Kitts , and J. Zawistowski . 2003 . Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mice. J. Nutr. 133 : 744-751 . (Pubitemid 36268349)
13. Xia , X. , W. Ling , J. Ma , M. Xia , M. Hou , Q. Wang , H. Zhu , and Z. Tang . 2006 . An anthocyanin-rich extract from black rice enhances atherosclerotic plaque stabilization in apolipoprotein E-deficient mice. J. Nutr. 136 : 2220-2225 . (Pubitemid 44156828)
14. Seymour , E. M. , A. A. Singer , A. Kirakosyan , D. E. Urcuyo-Llanes , P. B. Kaufman , and S. F. Bolling . 2008 . Altered hyperlipidemia, hepatic steatosis, and hepatic peroxisome proliferator-activated receptors in rats with intake of tart cherry. J. Med. Food . 11 : 252-259 . (Pubitemid 351948185)
15. Romanelli , A. , K. A. Martin , A. Toker , and J. Blenis . 1999 . P70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Mol. Cell. Biol. 19 : 2921-2928 . (Pubitemid 29144537)
16. Park , M. , J. Farrell , K. Lemmon , and D. A. York . 2009 . Enterostatin alters protein trafficking to inhibit insulin secretion in Beta-TC6 cells. Peptides . 30 : 1866-1873 .
17. Hoffmann , K. , J. Blaudszun , C. Brunken , W. W. Höpker , R. Tauber , and H. Steinhart . 2005 . New application of a subcellular fractionation method to kidney and testis for the determination of conjugated linoleic acid in selected cell organelles of healthy and cancerous human tissues. Anal. Bioanal. Chem. 381 : 1138-1144 . (Pubitemid 40512252)
18. Zheng , J. , and V. D. Ramirez . 2000 . Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals. Br. J. Pharmacol. 130 : 1115-1123 . (Pubitemid 30453547)
19. Zheng , J. , and V. D. Ramirez . 1999 . Purification and identification of an estrogen binding protein from rat brain: Oligomycin sensitivity- conferring protein (OSCP), a subunit of mitochondrial F0F1- ATP synthase/ATPase. J. Steroid Biochem. Mol. Biol. 68 : 65-75 . (Pubitemid 29130387)
20. Igal , R. A. , S. Wang , M. Gonzalez-Baró , and R. A. Coleman . 2001 . Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol. J. Biol. Chem. 276 : 42205-42212 .
21. Muoio , D. M. , K. Seefeld , and L. A. Witters . 1999 . AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: Evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem. J. 338 : 783-791 . (Pubitemid 29140087)
22. Park , S. G. , Y. S. Kang , J. Y. Kim , C. S. Lee , Y. G. Ko , W. J. Lee , K. U. Lee , Y. I. Yeom , and S. Kim . 2006 . Hormonal activity of AIMP1/p43 for glucose homeostasis. Proc. Natl. Acad. Sci. USA . 103 : 14913-14918 . (Pubitemid 44527828)
23. Nagle , C. A. , J. An , and M. Shiota . 2007 . Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J. Biol. Chem. 282 : 14807-14815 . (Pubitemid 47093356)
24. Kim , H. S. , C. Xiao , R. H. Wang , T. Lahusen , X. Xu , A. Vassilopoulos , G. Vazquez-Ortiz , W. I. Jeong , O. Park , S. H. Ki , et al . 2010 . Hepaticspecific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 12 : 224-236 .
25. Qin , X. , X. Xie , Y. Fan , J. Tian , Y. Guan , X. Wang , Y. Zhu , and N. Wang . 2008 . Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology . 48 : 432-441 .
26. Tietge , U. J. , A. Bakillah , C. Maugeais , K. Tsukamoto , M. Hussain , and D. J. Rader . 1999 . Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B. J. Lipid Res. 40 : 2134-2139 . (Pubitemid 29523440)
27. Pellon-Maison , M. , M. A. Montanaro , R. A. Coleman , and M. R. Gonzalez-Baró . 2007 . Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV). Biochim. Biophys. Acta . 1771 : 830-838 . (Pubitemid 46891298)
28. Boyer , P. D. 1997 . The ATP synthase-a splendid molecular machine. Annu. Rev. Biochem. 66 : 717-749 . (Pubitemid 27274672)
29. Menz , R. I. , J. E. Walker , and A. G. R. Leslie . 2001 . Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: Implications for the mechanism of rotary catalysis. Cell . 106 : 331-341 . (Pubitemid 32772617)
30. Cabezón , E. , I. Arechaga , P. Jonathan , G. Butler , and J. E. Walker . 2000 . Dimerization of bovine F1-ATPase by binding the inhibitor protein, IF1. J. Biol. Chem. 275 : 28353-28355 .
31. Dempsey , E. C. , A. C. Newton , D. Mochly-Rosen , A. P. Fields , M. E. Reyland , P. A. Insel , and R. O. Messing . 2000 . Protein kinase Cisozymes and the regulation of diverse cell responses. Am. J. Physiol. Lung Cell. Mol. Physiol. 279 : L429-L438 .
32. Sajan , M. P. , M. L. Standaert , S. Nimal , U. Varanasi , T. Pastoor , S. Mastorides , U. Braun , M. Leitges , and R. V. Farese . 2009 . The critical role of atypical protein kinase Cin activating hepatic SREBP-1c and NFkappaB in obesity. J. Lipid Res. 50 : 1133-1145 .
33. Brennan , A. M. , S. W. Suh , S. J. Won , P. Narasimhan , T. M. Kauppinen , H. Lee , Y. Edling , P. H. Chan , and R. A. Swanson . 2009 . NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat. Neurosci. 12 : 857-863 .
34. Xie , Z. , Y. Dong , R. Scholz , D. Neumann , and M. H. Zou . 2008 . Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation . 117 : 952-962 . (Pubitemid 351272593)
35. Geraldes , P. , and G. L. King . 2010 . Activation of protein kinase Cisoforms and its impact on diabetic complications. Circ. Res. 106 : 1319-1331 .
36. Liu , X. , M. L. Godwin , and G. Nowak . 2004 . Protein kinase C-alpha inhibits the repair of oxidative phosphorylation after S-(1,2- dichlorovinyl)-L-cysteine injury in renal cells. Am. J. Physiol. Renal Physiol. 287 : F64-F73 . (Pubitemid 38780584)
37. Xia , M. , M. Hou , H. Zhu , J. Ma , Z. Tang , Q. Wang , Y. Li , D. Chi , X. Yu , T. Zhao , et al . 2005 . Anthocyanins induce cholesterol effl ux from mouse peritoneal macrophages: The role of the peroxisome proligerator-activated receptor γ-liver X receptor α-ABCA1 pathway. J. Biol. Chem. 280 : 36792-36801 . (Pubitemid 41587759)
38. Pedersen , P. L. , and L. M. Amzel . 1993 . TP synthases. Structure, reaction center, mechanism, and regulation of one of nature's most unique machines. J. Biol. Chem. 268 : 9937-9940 . (Pubitemid 23150162)
39. Lin , C. L. , H. C. Huang , and J. K. Lin . 2007 . Theafl avins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. J. Lipid Res. 48 : 2334-2343 .
40. Brusq , J. M. , N. Ancellin , P. Grondin , R. Guillard , S. Martin , Y. Saintillan , and M. Issandou . 2006 . Inhibition of lipid synthesis through activation of AMP kinase: An additional mechanism for the hypolipidemic effects of berberine. J. Lipid Res. 47 : 1281-1288 . (Pubitemid 43830720)
41. Farese , R. V. , and M. P. Sajan . 2010 . Metabolic functions of atypical protein kinase C: "good" and "bad" as defi ned by nutritional status. Am. J. Physiol. Endocrinol. Metab. 298 : E385-E394 .
42. Roffey , J. , C. Rosse , and M. Linch . 2009 . Protein kinase Cintervention: The state of play. Curr. Opin. Cell Biol. 21 : 268-279 .
43. Steinberg , S. F. 2008 . Structural basis of protein kinase Cisoform function. Physiol. Rev. 88 : 1341-1378 .
44. Zhang , F. X. , W. Pan , and J. B. Hutchins . 1995 . Phosphorylation of F1F0 ATPase delta-subunit is regulated by platelet-derived growth factor in mouse cortical neurons in vitro. J. Neurochem. 65 : 2812-2815 . (Pubitemid 3002939)
45. Furukawa , S. , T. Fujita , M. Shimabukuro , M. Iwaki , Y. Yamada , Y. Nakajima , O. Nakayama , M. Makishima , M. Matsuda , and I. Shimomura . 2004 . Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114 : 1752-1761. (Pubitemid 40385531)