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Volumn 56, Issue 8, 2007, Pages 1124-1131

Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FATTY ACID; ICOSAPENTAENOIC ACID; OLEIC ACID; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; SMALL INTERFERING RNA; STEARIC ACID; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 34547193134     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2006.118059     Document Type: Article
Times cited : (180)

References (40)
  • 1
    • 13544269612 scopus 로고    scopus 로고
    • Hepatitis C virus core protein modulates TRAIL-mediated apoptosis by enhancing Bid cleavage and activation of mitochondria apoptosis signaling pathway
    • Chou AH, Tsai HF, Wu YY, et al. Hepatitis C virus core protein modulates TRAIL-mediated apoptosis by enhancing Bid cleavage and activation of mitochondria apoptosis signaling pathway. J Immunol 2005;174:2160-6.
    • (2005) J Immunol , vol.174 , pp. 2160-2166
    • Chou, A.H.1    Tsai, H.F.2    Wu, Y.Y.3
  • 2
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003;125:437-43.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 3
    • 4544335155 scopus 로고    scopus 로고
    • Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
    • Ribeiro PS, Cortez-Pinto H, Sola S, et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 2004;99:1708-17.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1708-1717
    • Ribeiro, P.S.1    Cortez-Pinto, H.2    Sola, S.3
  • 4
    • 0032904641 scopus 로고    scopus 로고
    • Toxicity of hepatotoxins: New insights into mechanisms and therapy
    • Wu J, Danielsson A, Zern MA. Toxicity of hepatotoxins: new insights into mechanisms and therapy. Expert Opin Invest Drugs 1999;8:585-607.
    • (1999) Expert Opin Invest Drugs , vol.8 , pp. 585-607
    • Wu, J.1    Danielsson, A.2    Zern, M.A.3
  • 5
    • 20444473800 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathogenesis of nonalcoholic fatty liver disease
    • Sanyal AJ. Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease. Nat Clin Pract Gastroenterol Hepatol 2005;2:46-53.
    • (2005) Nat Clin Pract Gastroenterol Hepatol , vol.2 , pp. 46-53
    • Sanyal, A.J.1
  • 6
    • 0348134733 scopus 로고    scopus 로고
    • Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
    • Feldstein AE, Canbay A, Guicciardi ME, et al. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol 2003;39:978-83.
    • (2003) J Hepatol , vol.39 , pp. 978-983
    • Feldstein, A.E.1    Canbay, A.2    Guicciardi, M.E.3
  • 7
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome
    • Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003;144:5159-65.
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 8
    • 0036233315 scopus 로고    scopus 로고
    • Mechanisms of lipoapoptosis: Implications for human heart disease
    • Listenberger LL, Schaffer JE. Mechanisms of lipoapoptosis: implications for human heart disease. Trends Cardiovasc Med 2002;12:134-8.
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 134-138
    • Listenberger, L.L.1    Schaffer, J.E.2
  • 9
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006;44:27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3
  • 10
    • 16644372319 scopus 로고    scopus 로고
    • Following a TRAIL: Update on a ligand and its five receptors
    • Kimberley FC, Screaton GR. Following a TRAIL: update on a ligand and its five receptors. Cell Res 2004;14:359-72.
    • (2004) Cell Res , vol.14 , pp. 359-372
    • Kimberley, F.C.1    Screaton, G.R.2
  • 11
    • 0031253977 scopus 로고    scopus 로고
    • Killer/DR5 is a DNA damage-inducible p53-regulated death receptor gene
    • Wu GS, Burns TF, McDonald ER 3rd, et al. Killer/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 1997;17:141-3.
    • (1997) Nat Genet , vol.17 , pp. 141-143
    • Wu, G.S.1    Burns, T.F.2    McDonald 3rd, E.R.3
  • 12
    • 0032522463 scopus 로고    scopus 로고
    • p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha
    • Sheikh MS, Burns TF, Huang Y, et al. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha. Cancer Res 1998;58:1593-8.
    • (1998) Cancer Res , vol.58 , pp. 1593-1598
    • Sheikh, M.S.1    Burns, T.F.2    Huang, Y.3
  • 13
    • 0031987277 scopus 로고    scopus 로고
    • Regulation of p53 downstream genes
    • El-Deiry WS. Regulation of p53 downstream genes. Semin Cancer Biol 1998;8:345-57.
    • (1998) Semin Cancer Biol , vol.8 , pp. 345-357
    • El-Deiry, W.S.1
  • 14
    • 0034732258 scopus 로고    scopus 로고
    • Wild-type p53 transactivates the killer/DR5 gene through an intronic sequence-specific DNA-binding site
    • Takimoto R, El-Deiry WS. Wild-type p53 transactivates the killer/DR5 gene through an intronic sequence-specific DNA-binding site. Oncogene 2000;19:1735-43.
    • (2000) Oncogene , vol.19 , pp. 1735-1743
    • Takimoto, R.1    El-Deiry, W.S.2
  • 15
    • 0346422479 scopus 로고    scopus 로고
    • Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-lerminal kinase-dependent pathway involving Sp1
    • Higuchi H, Grambihler A, Canbay A, et al. Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-lerminal kinase-dependent pathway involving Sp1. J Biol Chem 2004;279:51- 60.
    • (2004) J Biol Chem , vol.279 , pp. 51-60
    • Higuchi, H.1    Grambihler, A.2    Canbay, A.3
  • 16
    • 0027227827 scopus 로고
    • Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
    • Spivey JR, Bronk SF, Gores GJ. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J Clin Invest 1993;92:17-24.
    • (1993) J Clin Invest , vol.92 , pp. 17-24
    • Spivey, J.R.1    Bronk, S.F.2    Gores, G.J.3
  • 17
    • 33744948514 scopus 로고    scopus 로고
    • Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
    • Malhi H, Bronk SF, Werneburg NW, et al. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 2006;281:12093-101.
    • (2006) J Biol Chem , vol.281 , pp. 12093-12101
    • Malhi, H.1    Bronk, S.F.2    Werneburg, N.W.3
  • 18
    • 6344275146 scopus 로고    scopus 로고
    • Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle
    • Ren YG, Wagner KW, Knee DA, et al. Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle. Mol Biol Cell 2004;15:5064-74.
    • (2004) Mol Biol Cell , vol.15 , pp. 5064-5074
    • Ren, Y.G.1    Wagner, K.W.2    Knee, D.A.3
  • 19
    • 5644258322 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells
    • Zou W, Liu X, Yue P, et al. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res 2004;64:7570-8.
    • (2004) Cancer Res , vol.64 , pp. 7570-7578
    • Zou, W.1    Liu, X.2    Yue, P.3
  • 20
    • 0035851204 scopus 로고    scopus 로고
    • BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons
    • Harris CA, Johnson EM Jr. BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. J Biol Chem 2001;276:37754-60.
    • (2001) J Biol Chem , vol.276 , pp. 37754-37760
    • Harris, C.A.1    Johnson Jr, E.M.2
  • 21
    • 0034614658 scopus 로고    scopus 로고
    • Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage
    • Khorbonda S, Saxena S, Yoshida K, et al. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem 2000;275:322-7.
    • (2000) J Biol Chem , vol.275 , pp. 322-327
    • Khorbonda, S.1    Saxena, S.2    Yoshida, K.3
  • 22
    • 0035968287 scopus 로고    scopus 로고
    • Novel role for JNK as a stress-activated Bcl2 kinase
    • Deng X, Xiao L, Lang W, et al. Novel role for JNK as a stress-activated Bcl2 kinase. J Biol Chem 2001;276:23681-8.
    • (2001) J Biol Chem , vol.276 , pp. 23681-23688
    • Deng, X.1    Xiao, L.2    Lang, W.3
  • 23
    • 32044447161 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    • Chang L, Kamata H, Solinas G, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 2006;124:601-13.
    • (2006) Cell , vol.124 , pp. 601-613
    • Chang, L.1    Kamata, H.2    Solinas, G.3
  • 24
    • 33746379603 scopus 로고    scopus 로고
    • JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells
    • Kim BJ, Ryu SW, Song BJ. JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 2006;281:21256-65.
    • (2006) J Biol Chem , vol.281 , pp. 21256-21265
    • Kim, B.J.1    Ryu, S.W.2    Song, B.J.3
  • 25
    • 0034755341 scopus 로고    scopus 로고
    • Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
    • Nehra V, Angulo P, Buchman AL, et al. Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci 2001;46:2347-52.
    • (2001) Dig Dis Sci , vol.46 , pp. 2347-2352
    • Nehra, V.1    Angulo, P.2    Buchman, A.L.3
  • 26
    • 0032713075 scopus 로고    scopus 로고
    • Safety and antitumor activity of recombinant soluble Apo2 ligand
    • Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999;104:155-62.
    • (1999) J Clin Invest , vol.104 , pp. 155-162
    • Ashkenazi, A.1    Pai, R.C.2    Fong, S.3
  • 27
    • 0036899204 scopus 로고    scopus 로고
    • Detection of soluble TRAIL in HBV infected patients and its clinical implications
    • Han LH, Sun WS, Ma CH, et al. Detection of soluble TRAIL in HBV infected patients and its clinical implications. World J Gastroenterol 2002;8:1077-80.
    • (2002) World J Gastroenterol , vol.8 , pp. 1077-1080
    • Han, L.H.1    Sun, W.S.2    Ma, C.H.3
  • 28
    • 0042329166 scopus 로고    scopus 로고
    • Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression
    • Janssen HL, Higuchi H, Abdulkarim A, et al. Hepatitis B virus enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity by increasing TRAIL-R1/death receptor 4 expression. J Hepatol 2003;39:414-20.
    • (2003) J Hepatol , vol.39 , pp. 414-420
    • Janssen, H.L.1    Higuchi, H.2    Abdulkarim, A.3
  • 29
    • 0037268529 scopus 로고    scopus 로고
    • Involvement of TRAIL and its receptors in viral hepatitis
    • Mundt B, Kuhnel F, Zender L, et al. Involvement of TRAIL and its receptors in viral hepatitis. Faseb J 2003;17:94-6.
    • (2003) Faseb J , vol.17 , pp. 94-96
    • Mundt, B.1    Kuhnel, F.2    Zender, L.3
  • 30
    • 1542466794 scopus 로고    scopus 로고
    • Critical roles of TRAIL in hepatic cell death and hepatic inflammation
    • Zheng SJ, Wang P, Tsabary G, et al. Critical roles of TRAIL in hepatic cell death and hepatic inflammation. J Clin Invest 2004;113:58-64.
    • (2004) J Clin Invest , vol.113 , pp. 58-64
    • Zheng, S.J.1    Wang, P.2    Tsabary, G.3
  • 31
    • 27444433031 scopus 로고    scopus 로고
    • Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake
    • Mundt B, Wirth T, Zender L, et al. Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake. Gut 2005;54:1590-6.
    • (2005) Gut , vol.54 , pp. 1590-1596
    • Mundt, B.1    Wirth, T.2    Zender, L.3
  • 32
    • 0037405649 scopus 로고    scopus 로고
    • Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes
    • Qiao L, Han SI, Fang Y, et al. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 2003;23:3052-66.
    • (2003) Mol Cell Biol , vol.23 , pp. 3052-3066
    • Qiao, L.1    Han, S.I.2    Fang, Y.3
  • 33
    • 3843142885 scopus 로고    scopus 로고
    • Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1
    • Wang Y, Schattenberg JM, Rigoli RM, et al. Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1. J Biol Chem 2004;279:31089-97.
    • (2004) J Biol Chem , vol.279 , pp. 31089-31097
    • Wang, Y.1    Schattenberg, J.M.2    Rigoli, R.M.3
  • 34
    • 0036893515 scopus 로고    scopus 로고
    • JNK3 contributes to c-jun induction and apoptosis in 4-hydroxynonenal-treated sympathetic neurons
    • Bruckner SR, Estus S. JNK3 contributes to c-jun induction and apoptosis in 4-hydroxynonenal-treated sympathetic neurons. J Neurosci Res 2002;70:665-70.
    • (2002) J Neurosci Res , vol.70 , pp. 665-670
    • Bruckner, S.R.1    Estus, S.2
  • 35
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002;420:333-6.
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 36
    • 33644813043 scopus 로고    scopus 로고
    • JNK1 but not JNK2 promotes the development of steatohepatitis in mice
    • Schattenberg JM, Singh R, Wang Y, et al. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 2006;43:163-72.
    • (2006) Hepatology , vol.43 , pp. 163-172
    • Schattenberg, J.M.1    Singh, R.2    Wang, Y.3
  • 37
    • 33745758229 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
    • Gunawan BK, Liu ZX, Han D, et al. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 2006;131:165-78.
    • (2006) Gastroenterology , vol.131 , pp. 165-178
    • Gunawan, B.K.1    Liu, Z.X.2    Han, D.3
  • 38
    • 33744956373 scopus 로고    scopus 로고
    • Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway
    • Wang Y, Singh R, Lefkowitch JH, et al. Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 2006;281:15258-67.
    • (2006) J Biol Chem , vol.281 , pp. 15258-15267
    • Wang, Y.1    Singh, R.2    Lefkowitch, J.H.3
  • 39
    • 0030996297 scopus 로고    scopus 로고
    • The receptor for the cytotoxic ligand TRAIL
    • Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997;276:111-3.
    • (1997) Science , vol.276 , pp. 111-113
    • Pan, G.1    O'Rourke, K.2    Chinnaiyan, A.M.3
  • 40
    • 0030792712 scopus 로고    scopus 로고
    • Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
    • Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997;277:818-21.
    • (1997) Science , vol.277 , pp. 818-821
    • Sheridan, J.P.1    Marsters, S.A.2    Pitti, R.M.3


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