메뉴 건너뛰기




Volumn 61, Issue 2, 2012, Pages 141-152

The epidemiology, pathogenesis and histopathology of fatty liver disease

Author keywords

Alcoholic liver disease; Histopathology; Insulin resistance; Liver biopsy; Metabolic syndrome; Non alcoholic fatty liver disease; Non alcoholic steatohepatitis; Steatosis

Indexed keywords

ADIPONECTIN; ALCOHOL; INSULIN; LEPTIN;

EID: 84864390922     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.04145.x     Document Type: Review
Times cited : (155)

References (102)
  • 2
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: a population-based cohort study
    • Adams LA, Lymp JF, St Sauver J et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005; 129; 113-121.
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 3
    • 33644700376 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients
    • Targher G, Bertolini L, Poli F et al. Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes 2005; 54; 3541-3546.
    • (2005) Diabetes , vol.54 , pp. 3541-3546
    • Targher, G.1    Bertolini, L.2    Poli, F.3
  • 4
    • 34247647418 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease
    • Hamaguchi M, Kojima T, Takeda N et al. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J. Gastroenterol. 2007; 13; 1579-1584.
    • (2007) World J. Gastroenterol. , vol.13 , pp. 1579-1584
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3
  • 5
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41; 1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 6
    • 84873062612 scopus 로고    scopus 로고
    • Note
    • Office for National Statistics. Death rates from alcohol-related diseases Available at
  • 7
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004; 40; 1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 8
    • 0033857654 scopus 로고    scopus 로고
    • Pathological and virological findings in patients with persistent hypertransaminasaemia of unknown aetiology
    • Berasain C, Betes M, Panizo A et al. Pathological and virological findings in patients with persistent hypertransaminasaemia of unknown aetiology. Gut 2000; 47; 429-435.
    • (2000) Gut , vol.47 , pp. 429-435
    • Berasain, C.1    Betes, M.2    Panizo, A.3
  • 9
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors
    • Wanless IR Lentz JS. Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 1990; 12; 1106-1110.
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 10
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study
    • Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology 2005; 42; 44-52.
    • (2005) Hepatology , vol.42 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3    Tiribelli, C.4    Marchesini, G.5    Bellentani, S.6
  • 11
    • 0037221394 scopus 로고    scopus 로고
    • Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States
    • Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology 2003; 124; 71-79.
    • (2003) Gastroenterology , vol.124 , pp. 71-79
    • Ruhl, C.E.1    Everhart, J.E.2
  • 12
    • 77952680758 scopus 로고    scopus 로고
    • Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study
    • Speliotes EK, Massaro JM, Hoffmann U et al. Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study. Hepatology 2010; 51; 1979-1987.
    • (2010) Hepatology , vol.51 , pp. 1979-1987
    • Speliotes, E.K.1    Massaro, J.M.2    Hoffmann, U.3
  • 13
    • 67651148531 scopus 로고    scopus 로고
    • Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the United States population
    • Ioannou GN, Morrow OB, Connole ML, Lee SP. Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the United States population. Hepatology 2009; 50; 175-184.
    • (2009) Hepatology , vol.50 , pp. 175-184
    • Ioannou, G.N.1    Morrow, O.B.2    Connole, M.L.3    Lee, S.P.4
  • 14
    • 78049516031 scopus 로고    scopus 로고
    • Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins
    • Vitaglione P, Morisco F, Mazzone G et al. Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins. Hepatology 2010; 52; 1652-1661.
    • (2010) Hepatology , vol.52 , pp. 1652-1661
    • Vitaglione, P.1    Morisco, F.2    Mazzone, G.3
  • 15
    • 56649123256 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease: a global perspective
    • Lazo M, Clark JM. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin. Liver Dis. 2008; 28; 339-350.
    • (2008) Semin. Liver Dis. , vol.28 , pp. 339-350
    • Lazo, M.1    Clark, J.M.2
  • 16
    • 34249668818 scopus 로고    scopus 로고
    • Epidemiology and natural history of NAFLD and NASH
    • vii.
    • Ong JP, Younossi ZM. Epidemiology and natural history of NAFLD and NASH. Clin. Liver Dis. 2007; 11; 1-16, vii.
    • (2007) Clin. Liver Dis. , vol.11 , pp. 1-16
    • Ong, J.P.1    Younossi, Z.M.2
  • 17
    • 0034862590 scopus 로고    scopus 로고
    • Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology
    • Skelly MM, James PD, Ryder SD. Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology. J. Hepatol. 2001; 35; 195-199.
    • (2001) J. Hepatol. , vol.35 , pp. 195-199
    • Skelly, M.M.1    James, P.D.2    Ryder, S.D.3
  • 18
    • 0032822946 scopus 로고    scopus 로고
    • Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients
    • Daniel S, Ben-Menachem T, Vasudevan G, Ma CK, Blumenkehl M. Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients. Am. J. Gastroenterol. 1999; 94; 3010-3014.
    • (1999) Am. J. Gastroenterol. , vol.94 , pp. 3010-3014
    • Daniel, S.1    Ben-Menachem, T.2    Vasudevan, G.3    Ma, C.K.4    Blumenkehl, M.5
  • 19
    • 4344628555 scopus 로고    scopus 로고
    • The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    • viii.
    • McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin. Liver Dis. 2004; 8; 521-533, viii.
    • (2004) Clin. Liver Dis. , vol.8 , pp. 521-533
    • McCullough, A.J.1
  • 20
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzen LE, Mathiesen UL et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44; 865-873.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 21
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma
    • Bugianesi E, Leone N, Vanni E et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002; 123; 134-140.
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3
  • 22
    • 0036894480 scopus 로고    scopus 로고
    • NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States
    • Marrero JA, Fontana RJ, Su GL, Conjeevaram HS, Emick DM, Lok AS. NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 2002; 36; 1349-1354.
    • (2002) Hepatology , vol.36 , pp. 1349-1354
    • Marrero, J.A.1    Fontana, R.J.2    Su, G.L.3    Conjeevaram, H.S.4    Emick, D.M.5    Lok, A.S.6
  • 23
    • 18544365700 scopus 로고    scopus 로고
    • Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
    • Ratziu V, Bonyhay L, Di Martino V et al. Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis. Hepatology 2002; 35; 1485-1493.
    • (2002) Hepatology , vol.35 , pp. 1485-1493
    • Ratziu, V.1    Bonyhay, L.2    Di Martino, V.3
  • 24
    • 0035991455 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis
    • Shimada M, Hashimoto E, Taniai M et al. Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis. J. Hepatol. 2002; 37; 154-160.
    • (2002) J. Hepatol. , vol.37 , pp. 154-160
    • Shimada, M.1    Hashimoto, E.2    Taniai, M.3
  • 25
    • 4644261918 scopus 로고    scopus 로고
    • Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma
    • Bullock RE, Zaitoun AM, Aithal GP, Ryder SD, Beckingham IJ, Lobo DN. Association of non-alcoholic steatohepatitis without significant fibrosis with hepatocellular carcinoma. J. Hepatol. 2004; 41; 685-686.
    • (2004) J. Hepatol. , vol.41 , pp. 685-686
    • Bullock, R.E.1    Zaitoun, A.M.2    Aithal, G.P.3    Ryder, S.D.4    Beckingham, I.J.5    Lobo, D.N.6
  • 26
    • 15544382574 scopus 로고    scopus 로고
    • Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study
    • Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 2005; 54; 533-539.
    • (2005) Gut , vol.54 , pp. 533-539
    • Davila, J.A.1    Morgan, R.O.2    Shaib, Y.3    McGlynn, K.A.4    El-Serag, H.B.5
  • 27
    • 0029165057 scopus 로고
    • Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver
    • Teli MR, Day CP, Burt AD, Bennett MK, James OF. Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 1995; 346; 987-990.
    • (1995) Lancet , vol.346 , pp. 987-990
    • Teli, M.R.1    Day, C.P.2    Burt, A.D.3    Bennett, M.K.4    James, O.F.5
  • 29
  • 30
    • 0041760773 scopus 로고    scopus 로고
    • Assessment of prognosis in alcoholic liver disease: can serum hyaluronate replace liver biopsy?
    • Phillips MG, Preedy VR, Hughes RD. Assessment of prognosis in alcoholic liver disease: can serum hyaluronate replace liver biopsy? Eur. J. Gastroenterol. Hepatol. 2003; 15; 941-944.
    • (2003) Eur. J. Gastroenterol. Hepatol. , vol.15 , pp. 941-944
    • Phillips, M.G.1    Preedy, V.R.2    Hughes, R.D.3
  • 31
    • 0034864068 scopus 로고    scopus 로고
    • The critical dimension of ethnicity in liver cirrhosis mortality statistics
    • Stinson FS, Grant BF, Dufour MC. The critical dimension of ethnicity in liver cirrhosis mortality statistics. Alcohol. Clin. Exp. Res. 2001; 25; 1181-1187.
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 1181-1187
    • Stinson, F.S.1    Grant, B.F.2    Dufour, M.C.3
  • 32
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • Marchesini G, Brizi M, Morselli-Labate AM et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am. J. Med. 1999; 107; 450-455.
    • (1999) Am. J. Med. , vol.107 , pp. 450-455
    • Marchesini, G.1    Brizi, M.2    Morselli-Labate, A.M.3
  • 33
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two 'hits'?
    • Day CP, James OF. Steatohepatitis: a tale of two 'hits'? Gastroenterology 1998; 114; 842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 35
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S, Abeygunasekera S, Farrell GC et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002; 35; 373-379.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3
  • 36
    • 0033562693 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: another disease of affluence
    • James O, Day C. Non-alcoholic steatohepatitis: another disease of affluence. Lancet 1999; 353; 1634-1636.
    • (1999) Lancet , vol.353 , pp. 1634-1636
    • James, O.1    Day, C.2
  • 37
    • 33845490856 scopus 로고    scopus 로고
    • The role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider KM, Kahn SE. The role of insulin resistance in nonalcoholic fatty liver disease. J. Clin. Endocrinol. Metab. 2006; 91; 4753-4761.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 38
    • 33644955272 scopus 로고    scopus 로고
    • Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    • Anstee QM, Goldin RD. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int. J. Exp. Pathol. 2006; 87; 1-16.
    • (2006) Int. J. Exp. Pathol. , vol.87 , pp. 1-16
    • Anstee, Q.M.1    Goldin, R.D.2
  • 40
    • 33748111665 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance
    • Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006; 131; 934-945.
    • (2006) Gastroenterology , vol.131 , pp. 934-945
    • Tilg, H.1    Hotamisligil, G.S.2
  • 41
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259; 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 42
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein AE, Werneburg NW, Canbay A et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004; 40; 185-194.
    • (2004) Hepatology , vol.40 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3
  • 43
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li Z, Yang S, Lin H et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003; 37; 343-350.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3
  • 44
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Crespo J, Cayon A, Fernandez-Gil P et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 2001; 34; 1158-1163.
    • (2001) Hepatology , vol.34 , pp. 1158-1163
    • Crespo, J.1    Cayon, A.2    Fernandez-Gil, P.3
  • 45
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele L, Valenza V, La Torre G et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009; 49; 1877-1887.
    • (2009) Hepatology , vol.49 , pp. 1877-1887
    • Miele, L.1    Valenza, V.2    La Torre, G.3
  • 46
    • 0035658444 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis
    • Reddy JK. Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2001; 281; G1333-G1339.
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.281
    • Reddy, J.K.1
  • 47
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sargent C, Mirshahi F et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120; 1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 48
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 2004; 114; 147-152.
    • (2004) J. Clin. Invest. , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 49
    • 12844251988 scopus 로고    scopus 로고
    • Mechanisms of non-alcoholic steatohepatitis
    • McClain CJ, Mokshagundam SP, Barve SS et al. Mechanisms of non-alcoholic steatohepatitis. Alcohol 2004; 34; 67-79.
    • (2004) Alcohol , vol.34 , pp. 67-79
    • McClain, C.J.1    Mokshagundam, S.P.2    Barve, S.S.3
  • 50
    • 0242438087 scopus 로고    scopus 로고
    • Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis
    • George J, Pera N, Phung N, Leclercq I, Yun Hou J, Farrell G. Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis. J. Hepatol. 2003; 39; 756-764.
    • (2003) J. Hepatol. , vol.39 , pp. 756-764
    • George, J.1    Pera, N.2    Phung, N.3    Leclercq, I.4    Yun Hou, J.5    Farrell, G.6
  • 51
    • 0033515761 scopus 로고    scopus 로고
    • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    • Arita Y, Kihara S, Ouchi N et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 1999; 257; 79-83.
    • (1999) Biochem. Biophys. Res. Commun. , vol.257 , pp. 79-83
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 52
    • 0037135523 scopus 로고    scopus 로고
    • Disruption of adiponectin causes insulin resistance and neointimal formation
    • Kubota N, Terauchi Y, Yamauchi T et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J. Biol. Chem. 2002; 277; 25863-25866.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25863-25866
    • Kubota, N.1    Terauchi, Y.2    Yamauchi, T.3
  • 55
    • 0036063777 scopus 로고    scopus 로고
    • Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    • Maeda N, Shimomura I, Kishida K et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat. Med. 2002; 8; 731-737.
    • (2002) Nat. Med. , vol.8 , pp. 731-737
    • Maeda, N.1    Shimomura, I.2    Kishida, K.3
  • 56
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 2003; 112; 91-100.
    • (2003) J. Clin. Invest. , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 57
    • 0036234147 scopus 로고    scopus 로고
    • Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
    • Ikejima K, Takei Y, Honda H et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002; 122; 1399-1410.
    • (2002) Gastroenterology , vol.122 , pp. 1399-1410
    • Ikejima, K.1    Takei, Y.2    Honda, H.3
  • 58
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • Leclercq IA, Farrell GC, Schriemer R, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J. Hepatol. 2002; 37; 206-213.
    • (2002) J. Hepatol. , vol.37 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 60
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003; 125; 437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 62
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: the nexus of liver injury and fibrosis
    • Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 2004; 39; 273-278.
    • (2004) Hepatology , vol.39 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 64
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006; 44; 27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6
  • 65
    • 77955852465 scopus 로고    scopus 로고
    • Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis
    • Anstee QM, Concas D, Kudo H et al. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. J. Hepatol. 2010; 53; 542-550.
    • (2010) J. Hepatol. , vol.53 , pp. 542-550
    • Anstee, Q.M.1    Concas, D.2    Kudo, H.3
  • 66
    • 37749032395 scopus 로고    scopus 로고
    • Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers
    • author reply 2048.
    • Mitry RR, De Bruyne R, Quaglia A, Hughes RD, Dhawan A. Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers. Hepatology 2007; 46; 2047-2048; author reply 2048.
    • (2007) Hepatology , vol.46 , pp. 2047-2048
    • Mitry, R.R.1    De Bruyne, R.2    Quaglia, A.3    Hughes, R.D.4    Dhawan, A.5
  • 67
    • 55149102644 scopus 로고    scopus 로고
    • Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients
    • Diab DL, Yerian L, Schauer P et al. Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Clin. Gastroenterol. Hepatol. 2008; 6; 1249-1254.
    • (2008) Clin. Gastroenterol. Hepatol. , vol.6 , pp. 1249-1254
    • Diab, D.L.1    Yerian, L.2    Schauer, P.3
  • 68
    • 77956636268 scopus 로고    scopus 로고
    • The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    • Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 2010; 52; 894-903.
    • (2010) Hepatology , vol.52 , pp. 894-903
    • Rotman, Y.1    Koh, C.2    Zmuda, J.M.3    Kleiner, D.E.4    Liang, T.J.5
  • 69
    • 12844283403 scopus 로고    scopus 로고
    • Obesity and alcoholic liver disease
    • Diehl AM. Obesity and alcoholic liver disease. Alcohol 2004; 34; 81-87.
    • (2004) Alcohol , vol.34 , pp. 81-87
    • Diehl, A.M.1
  • 70
    • 33845927120 scopus 로고    scopus 로고
    • Alcohol, oxidative stress and free radical damage
    • Albano E. Alcohol, oxidative stress and free radical damage. Proc. Nutr. Soc. 2006; 65; 278-290.
    • (2006) Proc. Nutr. Soc. , vol.65 , pp. 278-290
    • Albano, E.1
  • 71
    • 33644527617 scopus 로고    scopus 로고
    • Alcohol and oxidative liver injury
    • Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology 2006; 43; S63-S74.
    • (2006) Hepatology , vol.43
    • Dey, A.1    Cederbaum, A.I.2
  • 72
    • 33745890321 scopus 로고    scopus 로고
    • ER stress: can the liver cope?
    • Ji C, Kaplowitz N. ER stress: can the liver cope? J. Hepatol. 2006; 45; 321-333.
    • (2006) J. Hepatol. , vol.45 , pp. 321-333
    • Ji, C.1    Kaplowitz, N.2
  • 73
    • 33750505407 scopus 로고    scopus 로고
    • CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation
    • Bardag-Gorce F, French BA, Nan L et al. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Exp. Mol. Pathol. 2006; 81; 191-201.
    • (2006) Exp. Mol. Pathol. , vol.81 , pp. 191-201
    • Bardag-Gorce, F.1    French, B.A.2    Nan, L.3
  • 74
    • 33646440019 scopus 로고    scopus 로고
    • Expression and activity of inducible nitric oxide synthase and endothelial nitric oxide synthase correlate with ethanol-induced liver injury
    • Yuan GJ, Zhou XR, Gong ZJ, Zhang P, Sun XM, Zheng SH. Expression and activity of inducible nitric oxide synthase and endothelial nitric oxide synthase correlate with ethanol-induced liver injury. World J. Gastroenterol. 2006; 12; 2375-2381.
    • (2006) World J. Gastroenterol. , vol.12 , pp. 2375-2381
    • Yuan, G.J.1    Zhou, X.R.2    Gong, Z.J.3    Zhang, P.4    Sun, X.M.5    Zheng, S.H.6
  • 75
    • 33751253098 scopus 로고    scopus 로고
    • Metabolic basis of ethanol-induced hepatic and pancreatic injury in hepatic alcohol dehydrogenase deficient deer mice
    • Bhopale KK, Wu H, Boor PJ, Popov VL, Ansari GA, Kaphalia BS. Metabolic basis of ethanol-induced hepatic and pancreatic injury in hepatic alcohol dehydrogenase deficient deer mice. Alcohol 2006; 39; 179-188.
    • (2006) Alcohol , vol.39 , pp. 179-188
    • Bhopale, K.K.1    Wu, H.2    Boor, P.J.3    Popov, V.L.4    Ansari, G.A.5    Kaphalia, B.S.6
  • 76
    • 0031979979 scopus 로고    scopus 로고
    • Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil
    • Polavarapu R, Spitz DR, Sim JE et al. Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil. Hepatology 1998; 27; 1317-1323.
    • (1998) Hepatology , vol.27 , pp. 1317-1323
    • Polavarapu, R.1    Spitz, D.R.2    Sim, J.E.3
  • 77
    • 0031971248 scopus 로고    scopus 로고
    • Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole
    • Fang C, Lindros KO, Badger TM, Ronis MJ, Ingelman-Sundberg M. Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole. Hepatology 1998; 27; 1304-1310.
    • (1998) Hepatology , vol.27 , pp. 1304-1310
    • Fang, C.1    Lindros, K.O.2    Badger, T.M.3    Ronis, M.J.4    Ingelman-Sundberg, M.5
  • 78
    • 0031802169 scopus 로고    scopus 로고
    • Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells
    • Neuman MG, Shear NH, Bellentani S, Tiribelli C. Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells. Gastroenterology 1998; 115; 157-166.
    • (1998) Gastroenterology , vol.115 , pp. 157-166
    • Neuman, M.G.1    Shear, N.H.2    Bellentani, S.3    Tiribelli, C.4
  • 79
    • 59549106331 scopus 로고    scopus 로고
    • Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    • Keshavarzian A, Farhadi A, Forsyth CB et al. Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats. J. Hepatol. 2009; 50; 538-547.
    • (2009) J. Hepatol. , vol.50 , pp. 538-547
    • Keshavarzian, A.1    Farhadi, A.2    Forsyth, C.B.3
  • 80
    • 33846883075 scopus 로고    scopus 로고
    • Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes
    • Chen X, Sebastian BM, Nagy LE. Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes. Am. J. Physiol. Endocrinol. Metab. 2007; 292; E621-E628.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292
    • Chen, X.1    Sebastian, B.M.2    Nagy, L.E.3
  • 81
    • 33746360865 scopus 로고    scopus 로고
    • Serum leptin in patients with alcoholic liver disease
    • Naveau S, Perlemuter G, Chaillet M et al. Serum leptin in patients with alcoholic liver disease. Alcohol. Clin. Exp. Res. 2006; 30; 1422-1428.
    • (2006) Alcohol. Clin. Exp. Res. , vol.30 , pp. 1422-1428
    • Naveau, S.1    Perlemuter, G.2    Chaillet, M.3
  • 82
    • 33747048700 scopus 로고    scopus 로고
    • Effect of leptin administration on membrane-bound adenosine triphosphatase activity in ethanol-induced experimental liver toxicity
    • Balasubramaniyan V, Viswanathan P, Nalini N. Effect of leptin administration on membrane-bound adenosine triphosphatase activity in ethanol-induced experimental liver toxicity. J. Pharm. Pharmacol. 2006; 58; 1113-1119.
    • (2006) J. Pharm. Pharmacol. , vol.58 , pp. 1113-1119
    • Balasubramaniyan, V.1    Viswanathan, P.2    Nalini, N.3
  • 83
    • 56649112801 scopus 로고    scopus 로고
    • Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive
    • Wieckowska A, Feldstein AE. Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive. Semin. Liver Dis. 2008; 28; 386-395.
    • (2008) Semin. Liver Dis. , vol.28 , pp. 386-395
    • Wieckowska, A.1    Feldstein, A.E.2
  • 84
    • 63449098935 scopus 로고    scopus 로고
    • Quantitative analysis of T2-correction in single-voxel magnetic resonance spectroscopy of hepatic lipid fraction
    • Sharma P, Martin DR, Pineda N et al. Quantitative analysis of T2-correction in single-voxel magnetic resonance spectroscopy of hepatic lipid fraction. J. Magn. Reson. Imaging 2009; 29; 629-635.
    • (2009) J. Magn. Reson. Imaging , vol.29 , pp. 629-635
    • Sharma, P.1    Martin, D.R.2    Pineda, N.3
  • 85
    • 1942454793 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis
    • Brunt EM. Nonalcoholic steatohepatitis. Semin. Liver Dis. 2004; 24; 3-20.
    • (2004) Semin. Liver Dis. , vol.24 , pp. 3-20
    • Brunt, E.M.1
  • 86
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37; 1202-1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 87
    • 85009031113 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis clinical research network
    • 244.
    • Nonalcoholic steatohepatitis clinical research network. Hepatology 2003; 37; 244.
    • (2003) Hepatology , vol.37
  • 89
    • 77956269092 scopus 로고    scopus 로고
    • Hepatocellular ballooning in NASH
    • Caldwell S, Ikura Y, Dias D et al. Hepatocellular ballooning in NASH. J. Hepatol. 2010; 53; 719-723.
    • (2010) J. Hepatol. , vol.53 , pp. 719-723
    • Caldwell, S.1    Ikura, Y.2    Dias, D.3
  • 90
    • 77949588202 scopus 로고    scopus 로고
    • Physiological hepatic nuclear vacuolation-how long does it persist?
    • Levene AP, Goldin RD. Physiological hepatic nuclear vacuolation-how long does it persist? Histopathology 2010; 56; 426-429.
    • (2010) Histopathology , vol.56 , pp. 426-429
    • Levene, A.P.1    Goldin, R.D.2
  • 92
    • 0036144410 scopus 로고    scopus 로고
    • p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases
    • Zatloukal K, Stumptner C, Fuchsbichler A et al. p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. Am. J. Pathol. 2002; 160; 255-263.
    • (2002) Am. J. Pathol. , vol.160 , pp. 255-263
    • Zatloukal, K.1    Stumptner, C.2    Fuchsbichler, A.3
  • 93
    • 40949123364 scopus 로고    scopus 로고
    • Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis
    • Lackner C, Gogg-Kamerer M, Zatloukal K, Stumptner C, Brunt EM, Denk H. Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis. J. Hepatol. 2008; 48; 821-828.
    • (2008) J. Hepatol. , vol.48 , pp. 821-828
    • Lackner, C.1    Gogg-Kamerer, M.2    Zatloukal, K.3    Stumptner, C.4    Brunt, E.M.5    Denk, H.6
  • 94
    • 4043132498 scopus 로고    scopus 로고
    • Portal fibrosis and hepatic steatosis in morbidly obese subjects: a spectrum of nonalcoholic fatty liver disease
    • Abrams GA, Kunde SS, Lazenby AJ, Clements RH. Portal fibrosis and hepatic steatosis in morbidly obese subjects: a spectrum of nonalcoholic fatty liver disease. Hepatology 2004; 40; 475-483.
    • (2004) Hepatology , vol.40 , pp. 475-483
    • Abrams, G.A.1    Kunde, S.S.2    Lazenby, A.J.3    Clements, R.H.4
  • 95
    • 63349106888 scopus 로고    scopus 로고
    • Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
    • Brunt EM, Kleiner DE, Wilson LA et al. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network. Hepatology 2009; 49; 809-820.
    • (2009) Hepatology , vol.49 , pp. 809-820
    • Brunt, E.M.1    Kleiner, D.E.2    Wilson, L.A.3
  • 96
    • 33646362256 scopus 로고    scopus 로고
    • Alcohol and hepatitis C: do we have a drinking problem?
    • Everhart JE. Alcohol and hepatitis C: do we have a drinking problem? Gastroenterology 2006; 130; 1912-1914.
    • (2006) Gastroenterology , vol.130 , pp. 1912-1914
    • Everhart, J.E.1
  • 97
    • 0032451389 scopus 로고    scopus 로고
    • Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology
    • McCullough AJ, O'Connor JF. Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am. J. Gastroenterol. 1998; 93; 2022-2036.
    • (1998) Am. J. Gastroenterol. , vol.93 , pp. 2022-2036
    • McCullough, A.J.1    O'Connor, J.F.2
  • 98
    • 70349773095 scopus 로고    scopus 로고
    • Histopathology of non-alcoholic fatty liver disease
    • Brunt EM. Histopathology of non-alcoholic fatty liver disease. Clin. Liver Dis. 2009; 13; 533-544.
    • (2009) Clin. Liver Dis. , vol.13 , pp. 533-544
    • Brunt, E.M.1
  • 99
    • 29144438774 scopus 로고    scopus 로고
    • Clinical and pathological features of non-alcoholic steatohepatitis
    • Nonomura A, Enomoto Y, Takeda M et al. Clinical and pathological features of non-alcoholic steatohepatitis. Hepatol. Res. 2005; 33; 116-121.
    • (2005) Hepatol. Res. , vol.33 , pp. 116-121
    • Nonomura, A.1    Enomoto, Y.2    Takeda, M.3
  • 100
    • 0023197521 scopus 로고
    • Comparison between nonalcoholic steatohepatitis and alcoholic hepatitis
    • Itoh S, Yougel T, Kawagoe K. Comparison between nonalcoholic steatohepatitis and alcoholic hepatitis. Am. J. Gastroenterol. 1987; 82; 650-654.
    • (1987) Am. J. Gastroenterol. , vol.82 , pp. 650-654
    • Itoh, S.1    Yougel, T.2    Kawagoe, K.3
  • 101
    • 0035052345 scopus 로고    scopus 로고
    • Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis
    • Contos MJ, Cales W, Sterling RK et al. Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis. Liver Transpl. 2001; 7; 363-373.
    • (2001) Liver Transpl. , vol.7 , pp. 363-373
    • Contos, M.J.1    Cales, W.2    Sterling, R.K.3
  • 102
    • 15744403722 scopus 로고    scopus 로고
    • The use of protein tyrosine phosphatase 1B and insulin receptor immunostains to differentiate nonalcoholic from alcoholic steatohepatitis in liver biopsy specimens
    • Sanderson SO, Smyrk TC. The use of protein tyrosine phosphatase 1B and insulin receptor immunostains to differentiate nonalcoholic from alcoholic steatohepatitis in liver biopsy specimens. Am. J. Clin. Pathol. 2005; 123; 503-509.
    • (2005) Am. J. Clin. Pathol. , vol.123 , pp. 503-509
    • Sanderson, S.O.1    Smyrk, T.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.