-
1
-
-
77649337140
-
Nonalcoholic fatty liver disease: pathology and pathogenesis
-
Tiniakos DG, Vos MB, Brunt EM. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol 2010; 5: 145-171.
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 145-171
-
-
Tiniakos, D.G.1
Vos, M.B.2
Brunt, E.M.3
-
2
-
-
0035431018
-
Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
-
Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001; 50: 1844-1850.
-
(2001)
Diabetes
, vol.50
, pp. 1844-1850
-
-
Marchesini, G.1
Brizi, M.2
Bianchi, G.3
Tomassetti, S.4
Bugianesi, E.5
Lenzi, M.6
-
3
-
-
0035084699
-
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
-
Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-1192.
-
(2001)
Gastroenterology
, vol.120
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
Sterling, R.K.6
-
4
-
-
75449094816
-
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
-
Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. HEPATOLOGY 2010; 51: 679-689.
-
(2010)
HEPATOLOGY
, vol.51
, pp. 679-689
-
-
Fabbrini, E.1
Sullivan, S.2
Klein, S.3
-
5
-
-
2342419920
-
Long term prognosis of fatty liver: risk of chronic liver disease and death
-
Dam-Larsen S, Franzmann M, Andersen IB, Christoffersen P, Jensen LB, Sorensen TI, et al. Long term prognosis of fatty liver: risk of chronic liver disease and death. Gut 2004; 53: 750-755.
-
(2004)
Gut
, vol.53
, pp. 750-755
-
-
Dam-Larsen, S.1
Franzmann, M.2
Andersen, I.B.3
Christoffersen, P.4
Jensen, L.B.5
Sorensen, T.I.6
-
6
-
-
11144351102
-
The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies
-
Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 2005; 42: 132-138.
-
(2005)
J Hepatol
, vol.42
, pp. 132-138
-
-
Adams, L.A.1
Sanderson, S.2
Lindor, K.D.3
Angulo, P.4
-
7
-
-
33750606061
-
Long-term follow-up of patients with NAFLD and elevated liver enzymes
-
Ekstedt M, Franzen LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. HEPATOLOGY 2006; 44: 865-873.
-
(2006)
HEPATOLOGY
, vol.44
, pp. 865-873
-
-
Ekstedt, M.1
Franzen, L.E.2
Mathiesen, U.L.3
Thorelius, L.4
Holmqvist, M.5
Bodemar, G.6
-
8
-
-
70350241227
-
The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years
-
Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 2009; 58: 1538-1544.
-
(2009)
Gut
, vol.58
, pp. 1538-1544
-
-
Feldstein, A.E.1
Charatcharoenwitthaya, P.2
Treeprasertsuk, S.3
Benson, J.T.4
Enders, F.B.5
Angulo, P.6
-
9
-
-
0031947715
-
Steatohepatitis: a tale of two "hits"?
-
Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998; 114: 842-845.
-
(1998)
Gastroenterology
, vol.114
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
10
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
-
Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008; 118: 829-838.
-
(2008)
J Clin Invest
, vol.118
, pp. 829-838
-
-
Postic, C.1
Girard, J.2
-
11
-
-
38649111018
-
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
-
Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 2008; 134: 424-431.
-
(2008)
Gastroenterology
, vol.134
, pp. 424-431
-
-
Fabbrini, E.1
Mohammed, B.S.2
Magkos, F.3
Korenblat, K.M.4
Patterson, B.W.5
Klein, S.6
-
12
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-1351.
-
(2005)
J Clin Invest
, vol.115
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
13
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 2008; 320: 1492-1496.
-
(2008)
Science
, vol.320
, pp. 1492-1496
-
-
Lee, A.H.1
Scapa, E.F.2
Cohen, D.E.3
Glimcher, L.H.4
-
14
-
-
77951875017
-
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
-
Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 2010; 375: 1634-1639.
-
(2010)
Lancet
, vol.375
, pp. 1634-1639
-
-
Sarwar, N.1
Sandhu, M.S.2
Ricketts, S.L.3
Butterworth, A.S.4
Di Angelantonio, E.5
Boekholdt, S.M.6
-
15
-
-
77949690002
-
DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation
-
Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, et al. DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest 2010; 120: 756-767.
-
(2010)
J Clin Invest
, vol.120
, pp. 756-767
-
-
Koliwad, S.K.1
Streeper, R.S.2
Monetti, M.3
Cornelissen, I.4
Chan, L.5
Terayama, K.6
-
16
-
-
34250356015
-
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
-
Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. HEPATOLOGY 2007; 45: 1366-1374.
-
(2007)
HEPATOLOGY
, vol.45
, pp. 1366-1374
-
-
Yamaguchi, K.1
Yang, L.2
McCall, S.3
Huang, J.4
Yu, X.X.5
Pandey, S.K.6
-
17
-
-
77953893410
-
Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia
-
Amaro A, Fabbrini E, Kars M, Yue P, Schechtman K, Schonfeld G, et al. Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia. Gastroenterology 2010; 139: 149-153.
-
(2010)
Gastroenterology
, vol.139
, pp. 149-153
-
-
Amaro, A.1
Fabbrini, E.2
Kars, M.3
Yue, P.4
Schechtman, K.5
Schonfeld, G.6
-
18
-
-
77953356804
-
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
-
Unger RH, Scherer PE. Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab 2010; 21: 345-352.
-
(2010)
Trends Endocrinol Metab
, vol.21
, pp. 345-352
-
-
Unger, R.H.1
Scherer, P.E.2
-
19
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
-
Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. HEPATOLOGY 2004; 40: 185-194.
-
(2004)
HEPATOLOGY
, vol.40
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
Guicciardi, M.E.4
Bronk, S.F.5
Rydzewski, R.6
-
20
-
-
33747626511
-
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
-
Mari M, Caballero F, Colell A, Morales A, Caballeria J, Fernandez A, et al. Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab 2006; 4: 185-198.
-
(2006)
Cell Metab
, vol.4
, pp. 185-198
-
-
Mari, M.1
Caballero, F.2
Colell, A.3
Morales, A.4
Caballeria, J.5
Fernandez, A.6
-
21
-
-
56649094325
-
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
-
Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis 2008; 28: 360-369.
-
(2008)
Semin Liver Dis
, vol.28
, pp. 360-369
-
-
Malhi, H.1
Gores, G.J.2
-
22
-
-
70049089646
-
Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
-
Alkhouri N, Dixon LJ, Feldstein AE. Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. Expert Rev Gastroenterol Hepatol 2009; 3: 445-451.
-
(2009)
Expert Rev Gastroenterol Hepatol
, vol.3
, pp. 445-451
-
-
Alkhouri, N.1
Dixon, L.J.2
Feldstein, A.E.3
-
23
-
-
0037309589
-
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
-
Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. HEPATOLOGY 2003; 37: 343-350.
-
(2003)
HEPATOLOGY
, vol.37
, pp. 343-350
-
-
Li, Z.1
Yang, S.2
Lin, H.3
Huang, J.4
Watkins, P.A.5
Moser, A.B.6
-
24
-
-
0012785395
-
Metformin reverses fatty liver disease in obese, leptin-deficient mice
-
Lin HZ, Yang SQ, Chuckaree C, Kuhajda F, Ronnet G, Diehl AM. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med 2000; 6: 998-1003.
-
(2000)
Nat Med
, vol.6
, pp. 998-1003
-
-
Lin, H.Z.1
Yang, S.Q.2
Chuckaree, C.3
Kuhajda, F.4
Ronnet, G.5
Diehl, A.M.6
-
25
-
-
0035131872
-
TNF-alpha is not the cause of fatty liver disease in obese diabetic mice
-
Memon RA, Grunfeld C, Feingold KR. TNF-alpha is not the cause of fatty liver disease in obese diabetic mice. Nat Med 2001; 7: 2-3.
-
(2001)
Nat Med
, vol.7
, pp. 2-3
-
-
Memon, R.A.1
Grunfeld, C.2
Feingold, K.R.3
-
26
-
-
31744446685
-
Hepatic steatosis in the absence of tumor necrosis factor in mice
-
Schnyder-Candrian S, Czarniecki J, Lerondel S, Corpataux J, Ryffel B, Schnyder B. Hepatic steatosis in the absence of tumor necrosis factor in mice. Cytokine 2005; 32: 287-295.
-
(2005)
Cytokine
, vol.32
, pp. 287-295
-
-
Schnyder-Candrian, S.1
Czarniecki, J.2
Lerondel, S.3
Corpataux, J.4
Ryffel, B.5
Schnyder, B.6
-
27
-
-
0037386110
-
Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
-
Tilg H, Jalan R, Kaser A, Davies NA, Offner FA, Hodges SJ, et al. Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. J Hepatol 2003; 38: 419-425.
-
(2003)
J Hepatol
, vol.38
, pp. 419-425
-
-
Tilg, H.1
Jalan, R.2
Kaser, A.3
Davies, N.A.4
Offner, F.A.5
Hodges, S.J.6
-
28
-
-
73349127065
-
Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
-
Clementi AH, Gaudy AM, Van Rooijen N, Pierce RH, Mooney RA. Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta 2009; 1792: 1062-1072.
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 1062-1072
-
-
Clementi, A.H.1
Gaudy, A.M.2
Van Rooijen, N.3
Pierce, R.H.4
Mooney, R.A.5
-
29
-
-
77951146612
-
C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
-
Obstfeld AE, Sugaru E, Thearle M, Francisco AM, Gayet C, Ginsberg HN, et al. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 2010; 59: 916-925.
-
(2010)
Diabetes
, vol.59
, pp. 916-925
-
-
Obstfeld, A.E.1
Sugaru, E.2
Thearle, M.3
Francisco, A.M.4
Gayet, C.5
Ginsberg, H.N.6
-
30
-
-
57349137214
-
Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
-
Tetri LH, Basaranoglu M, Brunt EM, Yerian LM, Neuschwander-Tetri BA. Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol 2008; 295: G987-G995.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.295
-
-
Tetri, L.H.1
Basaranoglu, M.2
Brunt, E.M.3
Yerian, L.M.4
Neuschwander-Tetri, B.A.5
-
31
-
-
66449093225
-
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
-
Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009; 119: 1322-1334.
-
(2009)
J Clin Invest
, vol.119
, pp. 1322-1334
-
-
Stanhope, K.L.1
Schwarz, J.M.2
Keim, N.L.3
Griffen, S.C.4
Bremer, A.A.5
Graham, J.L.6
-
32
-
-
77952692915
-
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
-
Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida A, Colvin R, Johnson RJ, et al. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. HEPATOLOGY 2010; 51: 1961-1971.
-
(2010)
HEPATOLOGY
, vol.51
, pp. 1961-1971
-
-
Abdelmalek, M.F.1
Suzuki, A.2
Guy, C.3
Unalp-Arida, A.4
Colvin, R.5
Johnson, R.J.6
-
33
-
-
66549106623
-
The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
-
Stevens EA, Mezrich JD, Bradfield CA. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 2009; 127: 299-311.
-
(2009)
Immunology
, vol.127
, pp. 299-311
-
-
Stevens, E.A.1
Mezrich, J.D.2
Bradfield, C.A.3
-
34
-
-
77955488532
-
A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis
-
Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, et al. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology 2010; 139: 653-663.
-
(2010)
Gastroenterology
, vol.139
, pp. 653-663
-
-
Lee, J.H.1
Wada, T.2
Febbraio, M.3
He, J.4
Matsubara, T.5
Lee, M.J.6
-
35
-
-
32944466887
-
Ecological and evolutionary forces shaping microbial diversity in the human intestine
-
Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006; 124: 837-848.
-
(2006)
Cell
, vol.124
, pp. 837-848
-
-
Ley, R.E.1
Peterson, D.A.2
Gordon, J.I.3
-
36
-
-
33747618036
-
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
-
Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A 2006; 103: 12511-12516.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 12511-12516
-
-
Dumas, M.E.1
Barton, R.H.2
Toye, A.3
Cloarec, O.4
Blancher, C.5
Rothwell, A.6
-
37
-
-
43549107065
-
Energy intake is associated with endotoxemia in apparently healthy men
-
Amar J, Burcelin R, Ruidavets JB, Cani PD, Fauvel J, Alessi MC, et al. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr 2008; 87: 1219-1223.
-
(2008)
Am J Clin Nutr
, vol.87
, pp. 1219-1223
-
-
Amar, J.1
Burcelin, R.2
Ruidavets, J.B.3
Cani, P.D.4
Fauvel, J.5
Alessi, M.C.6
-
38
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007; 56: 1761-1772.
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
Bastelica, D.6
-
39
-
-
68949148889
-
Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
-
Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, Ricci R, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. HEPATOLOGY 2009; 49: 1877-1887.
-
(2009)
HEPATOLOGY
, vol.49
, pp. 1877-1887
-
-
Miele, L.1
Valenza, V.2
La Torre, G.3
Montalto, M.4
Cammarota, G.5
Ricci, R.6
-
40
-
-
0029033928
-
Short-chain fatty acid topical treatment in distal ulcerative colitis
-
Vernia P, Marcheggiano A, Caprilli R, Frieri G, Corrao G, Valpiani D, et al. Short-chain fatty acid topical treatment in distal ulcerative colitis. Aliment Pharmacol Ther 1995; 9: 309-313.
-
(1995)
Aliment Pharmacol Ther
, vol.9
, pp. 309-313
-
-
Vernia, P.1
Marcheggiano, A.2
Caprilli, R.3
Frieri, G.4
Corrao, G.5
Valpiani, D.6
-
41
-
-
70350666634
-
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
-
Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009; 461: 1282-1286.
-
(2009)
Nature
, vol.461
, pp. 1282-1286
-
-
Maslowski, K.M.1
Vieira, A.T.2
Ng, A.3
Kranich, J.4
Sierro, F.5
Yu, D.6
-
42
-
-
8144226856
-
The gut microbiota as an environmental factor that regulates fat storage
-
Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004; 101: 15718-15723.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 15718-15723
-
-
Backhed, F.1
Ding, H.2
Wang, T.3
Hooper, L.V.4
Koh, G.Y.5
Nagy, A.6
-
44
-
-
0038363378
-
The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
-
Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, et al. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 2003; 278: 11312-11319.
-
(2003)
J Biol Chem
, vol.278
, pp. 11312-11319
-
-
Brown, A.J.1
Goldsworthy, S.M.2
Barnes, A.A.3
Eilert, M.M.4
Tcheang, L.5
Daniels, D.6
-
45
-
-
55949091259
-
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
-
Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A 2008; 105: 16767-16772.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16767-16772
-
-
Samuel, B.S.1
Shaito, A.2
Motoike, T.3
Rey, F.E.4
Backhed, F.5
Manchester, J.K.6
-
46
-
-
63349101854
-
VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice
-
Velayudham A, Dolganiuc A, Ellis M, Petrasek J, Kodys K, Mandrekar P, et al. VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. HEPATOLOGY 2009; 49: 989-997.
-
(2009)
HEPATOLOGY
, vol.49
, pp. 989-997
-
-
Velayudham, A.1
Dolganiuc, A.2
Ellis, M.3
Petrasek, J.4
Kodys, K.5
Mandrekar, P.6
-
47
-
-
65349182352
-
Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats
-
Esposito E, Iacono A, Bianco G, Autore G, Cuzzocrea S, Vajro P, et al. Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. J Nutr 2009; 139: 905-911.
-
(2009)
J Nutr
, vol.139
, pp. 905-911
-
-
Esposito, E.1
Iacono, A.2
Bianco, G.3
Autore, G.4
Cuzzocrea, S.5
Vajro, P.6
-
48
-
-
0035524488
-
Toll-like receptors and innate immunity
-
Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol 2001; 1: 135-145.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
49
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006; 116: 3015-3025.
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
50
-
-
34547602916
-
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007; 56: 1986-1998.
-
(2007)
Diabetes
, vol.56
, pp. 1986-1998
-
-
Tsukumo, D.M.1
Carvalho-Filho, M.A.2
Carvalheira, J.B.3
Prada, P.O.4
Hirabara, S.M.5
Schenka, A.A.6
-
51
-
-
73949110679
-
Saturated fatty acids do not directly stimulate Toll-like receptor signaling
-
Erridge C, Samani NJ. Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arterioscler Thromb Vasc Biol 2009; 29: 1944-1949.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1944-1949
-
-
Erridge, C.1
Samani, N.J.2
-
52
-
-
77953891627
-
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice
-
Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010; 139: 323-334.
-
(2010)
Gastroenterology
, vol.139
, pp. 323-334
-
-
Miura, K.1
Kodama, Y.2
Inokuchi, S.3
Schnabl, B.4
Aoyama, T.5
Ohnishi, H.6
-
53
-
-
77950250064
-
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
-
Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010; 328: 228-231.
-
(2010)
Science
, vol.328
, pp. 228-231
-
-
Vijay-Kumar, M.1
Aitken, J.D.2
Carvalho, F.A.3
Cullender, T.C.4
Mwangi, S.5
Srinivasan, S.6
-
54
-
-
33847733103
-
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
-
Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007; 13: 332-339.
-
(2007)
Nat Med
, vol.13
, pp. 332-339
-
-
Yamauchi, T.1
Nio, Y.2
Maki, T.3
Kobayashi, M.4
Takazawa, T.5
Iwabu, M.6
-
55
-
-
65349162789
-
Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies
-
Shetty S, Kusminski CM, Scherer PE. Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies. Trends Pharmacol Sci 2009; 30: 234-239.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 234-239
-
-
Shetty, S.1
Kusminski, C.M.2
Scherer, P.E.3
-
56
-
-
70349678823
-
Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis
-
Asano T, Watanabe K, Kubota N, Gunji T, Omata M, Kadowaki T, et al. Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis. J Gastroenterol Hepatol 2009; 24: 1669-1676.
-
(2009)
J Gastroenterol Hepatol
, vol.24
, pp. 1669-1676
-
-
Asano, T.1
Watanabe, K.2
Kubota, N.3
Gunji, T.4
Omata, M.5
Kadowaki, T.6
-
57
-
-
77951872309
-
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1
-
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, et al. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature 2010; 464: 1313- 1319.
-
(2010)
Nature
, vol.464
, pp. 1313-1319
-
-
Iwabu, M.1
Yamauchi, T.2
Okada-Iwabu, M.3
Sato, K.4
Nakagawa, T.5
Funata, M.6
-
58
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 2009; 9: 327-338.
-
(2009)
Cell Metab
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
Schug, T.T.2
Xu, Q.3
Surapureddi, S.4
Guo, X.5
Li, X.6
-
59
-
-
34848872799
-
Obesity-associated improvements in metabolic profile through expansion of adipose tissue.
-
Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007; 117: 2621-2637.
-
(2007)
J Clin Invest
, vol.117
, pp. 2621-2637
-
-
Kim, J.Y.1
van de, W.E.2
Laplante, M.3
Azzara, A.4
Trujillo, M.E.5
Hofmann, S.M.6
-
60
-
-
33748111665
-
Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance
-
Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006; 131: 934-945.
-
(2006)
Gastroenterology
, vol.131
, pp. 934-945
-
-
Tilg, H.1
Hotamisligil, G.S.2
-
61
-
-
77953516574
-
Leptin: the prototypic adipocytokine and its role in NAFLD.
-
Procaccini C, Galgani M, De Rosa V, Carbone F, La Rocca C, Ranucci G, et al. Leptin: the prototypic adipocytokine and its role in NAFLD. Curr Pharm Des 2010; 16: 1902-1912.
-
(2010)
Curr Pharm Des
, vol.16
, pp. 1902-1912
-
-
Procaccini, C.1
Galgani, M.2
De Rosa, V.3
Carbone, F.4
La Rocca, C.5
Ranucci, G.6
-
62
-
-
0030898516
-
Direct antidiabetic effect of leptin through triglyceride depletion of tissues
-
Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci U S A 1997; 94: 4637-4641.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 4637-4641
-
-
Shimabukuro, M.1
Koyama, K.2
Chen, G.3
Wang, M.Y.4
Trieu, F.5
Lee, Y.6
-
63
-
-
0030987368
-
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
-
Zhou YT, Shimabukuro M, Koyama K, Lee Y, Wang MY, Trieu F, et al. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci U S A 1997; 94: 6386- 6390.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 6386-6390
-
-
Zhou, Y.T.1
Shimabukuro, M.2
Koyama, K.3
Lee, Y.4
Wang, M.Y.5
Trieu, F.6
-
64
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
65
-
-
0031766093
-
Circulating interleukin 6 concentrations and insulin resistance in patients with cancer
-
Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K. Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. Br J Surg 1998; 85: 1658-1662.
-
(1998)
Br J Surg
, vol.85
, pp. 1658-1662
-
-
Makino, T.1
Noguchi, Y.2
Yoshikawa, T.3
Doi, C.4
Nomura, K.5
-
66
-
-
0035049305
-
Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women
-
Fernandez-Real JM, Vayreda M, Richart C, Gutierrez C, Broch M, Vendrell J, et al. Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J Clin Endocrinol Metab 2001; 86: 1154-1159.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 1154-1159
-
-
Fernandez-Real, J.M.1
Vayreda, M.2
Richart, C.3
Gutierrez, C.4
Broch, M.5
Vendrell, J.6
-
67
-
-
0028968879
-
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.
-
Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995; 95: 2111-2119.
-
(1995)
J Clin Invest
, vol.95
, pp. 2111-2119
-
-
Kern, P.A.1
Saghizadeh, M.2
Ong, J.M.3
Bosch, R.J.4
Deem, R.5
Simsolo, R.B.6
-
68
-
-
41649093318
-
Inflammatory mechanisms in the regulation of insulin resistance
-
Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 2008; 14: 222-231.
-
(2008)
Mol Med
, vol.14
, pp. 222-231
-
-
Tilg, H.1
Moschen, A.R.2
-
69
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008; 322: 1539-1543.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
-
70
-
-
77956114717
-
Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin-6 and tumour necrosis factor-alpha expression
-
Moschen AR, Molnar C, Geiger S, Graziadei I, Ebenbichler CF, Weiss H, et al. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin-6 and tumour necrosis factor-alpha expression. Gut 2010; 59: 1259-1264.
-
(2010)
Gut
, vol.59
, pp. 1259-1264
-
-
Moschen, A.R.1
Molnar, C.2
Geiger, S.3
Graziadei, I.4
Ebenbichler, C.F.5
Weiss, H.6
-
71
-
-
0037853260
-
Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
-
Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, et al. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem 2003; 278: 13740-13746.
-
(2003)
J Biol Chem
, vol.278
, pp. 13740-13746
-
-
Senn, J.J.1
Klover, P.J.2
Nowak, I.A.3
Zimmers, T.A.4
Koniaris, L.G.5
Furlanetto, R.W.6
-
72
-
-
9144229185
-
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
-
He W, Barak Y, Hevener A, Olson P, Liao D, Le J, et al. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A 2003; 100: 15712-15717.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15712-15717
-
-
He, W.1
Barak, Y.2
Hevener, A.3
Olson, P.4
Liao, D.5
Le, J.6
-
73
-
-
20944439189
-
Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
-
Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, et al. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A 2005; 102: 6207-6212.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 6207-6212
-
-
Jones, J.R.1
Barrick, C.2
Kim, K.A.3
Lindner, J.4
Blondeau, B.5
Fujimoto, Y.6
-
74
-
-
74949138985
-
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
-
Wueest S, Rapold RA, Schumann DM, Rytka JM, Schildknecht A, Nov O, et al. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest 2010; 120: 191-202.
-
(2010)
J Clin Invest
, vol.120
, pp. 191-202
-
-
Wueest, S.1
Rapold, R.A.2
Schumann, D.M.3
Rytka, J.M.4
Schildknecht, A.5
Nov, O.6
-
75
-
-
49649096375
-
Visceral fat: a key mediator of steatohepatitis in metabolic liver disease
-
van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. HEPATOLOGY 2008; 48: 449-457.
-
(2008)
HEPATOLOGY
, vol.48
, pp. 449-457
-
-
van der Poorten, D.1
Milner, K.L.2
Hui, J.3
Hodge, A.4
Trenell, M.I.5
Kench, J.G.6
-
76
-
-
77949840241
-
Trunk fat is associated with increased serum levels of alanine aminotransferase in the United States
-
Ruhl CE, Everhart JE. Trunk fat is associated with increased serum levels of alanine aminotransferase in the United States. Gastroenterology 2010; 138: 1346-1356.
-
(2010)
Gastroenterology
, vol.138
, pp. 1346-1356
-
-
Ruhl, C.E.1
Everhart, J.E.2
-
77
-
-
52749092267
-
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
-
Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008; 8: 301-309.
-
(2008)
Cell Metab
, vol.8
, pp. 301-309
-
-
Patsouris, D.1
Li, P.P.2
Thapar, D.3
Chapman, J.4
Olefsky, J.M.5
Neels, J.G.6
-
78
-
-
34347354309
-
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
-
Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007; 447: 1116-1120.
-
(2007)
Nature
, vol.447
, pp. 1116-1120
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Goforth, M.H.3
Morel, C.R.4
Subramanian, V.5
Mukundan, L.6
-
79
-
-
77949881805
-
Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype
-
Ohashi K, Parker JL, Ouchi N, Higuchi A, Vita JA, Gokce N, et al. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem 2010; 285: 6153- 6160.
-
(2010)
J Biol Chem
, vol.285
, pp. 6153-6160
-
-
Ohashi, K.1
Parker, J.L.2
Ouchi, N.3
Higuchi, A.4
Vita, J.A.5
Gokce, N.6
-
80
-
-
63649097100
-
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance
-
Chavey C, Lazennec G, Lagarrigue S, Clape C, Iankova I, Teyssier J, et al. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab 2009; 9: 339-349.
-
(2009)
Cell Metab
, vol.9
, pp. 339-349
-
-
Chavey, C.1
Lazennec, G.2
Lagarrigue, S.3
Clape, C.4
Iankova, I.5
Teyssier, J.6
-
81
-
-
74549167737
-
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
-
Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140: 197-208.
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, E.J.1
Lee, J.H.2
Yu, G.Y.3
He, G.4
Ali, S.R.5
Holzer, R.G.6
-
82
-
-
77949266016
-
Human IL6 enhances leptin action in mice
-
Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K, White MF. Human IL6 enhances leptin action in mice. Diabetologia 2010; 53: 525-535.
-
(2010)
Diabetologia
, vol.53
, pp. 525-535
-
-
Sadagurski, M.1
Norquay, L.2
Farhang, J.3
D'Aquino, K.4
Copps, K.5
White, M.F.6
-
83
-
-
0036152683
-
Interleukin-6-deficient mice develop mature-onset obesity
-
Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 2002; 8: 75-79.
-
(2002)
Nat Med
, vol.8
, pp. 75-79
-
-
Wallenius, V.1
Wallenius, K.2
Ahren, B.3
Rudling, M.4
Carlsten, H.5
Dickson, S.L.6
-
84
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005; 11: 183-190.
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
-
85
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005; 11: 191-198.
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
-
86
-
-
50249116184
-
The endoplasmic reticulum stress response in immunity and autoimmunity
-
Todd DJ, Lee AH, Glimcher LH. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008; 8: 663-674.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 663-674
-
-
Todd, D.J.1
Lee, A.H.2
Glimcher, L.H.3
-
87
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010; 140: 900-917.
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
88
-
-
33745828301
-
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
-
Wei Y, Wang D, Topczewski F, Pagliassotti MJ. Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 2006; 291: E275-E281.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.291
-
-
Wei, Y.1
Wang, D.2
Topczewski, F.3
Pagliassotti, M.J.4
-
89
-
-
51549107903
-
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
-
Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 2008; 134: 933-944.
-
(2008)
Cell
, vol.134
, pp. 933-944
-
-
Cao, H.1
Gerhold, K.2
Mayers, J.R.3
Wiest, M.M.4
Watkins, S.M.5
Hotamisligil, G.S.6
-
90
-
-
77949655879
-
Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis
-
Akazawa Y, Cazanave S, Mott JL, Elmi N, Bronk SF, Kohno S, et al. Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis. J Hepatol 2010; 52: 586-593.
-
(2010)
J Hepatol
, vol.52
, pp. 586-593
-
-
Akazawa, Y.1
Cazanave, S.2
Mott, J.L.3
Elmi, N.4
Bronk, S.F.5
Kohno, S.6
-
91
-
-
77950523710
-
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation
-
Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, et al. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med 2010; 16: 429-437.
-
(2010)
Nat Med
, vol.16
, pp. 429-437
-
-
Park, S.W.1
Zhou, Y.2
Lee, J.3
Lu, A.4
Sun, C.5
Chung, J.6
-
92
-
-
77950537400
-
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response
-
Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med 2010; 16: 438-445.
-
(2010)
Nat Med
, vol.16
, pp. 438-445
-
-
Winnay, J.N.1
Boucher, J.2
Mori, M.A.3
Ueki, K.4
Kahn, C.R.5
-
93
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 2009; 9: 35-51.
-
(2009)
Cell Metab
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
Nie, D.6
-
94
-
-
66049108823
-
The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis
-
Sha H, He Y, Chen H, Wang C, Zenno A, Shi H, et al. The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab 2009; 9: 556-564.
-
(2009)
Cell Metab
, vol.9
, pp. 556-564
-
-
Sha, H.1
He, Y.2
Chen, H.3
Wang, C.4
Zenno, A.5
Shi, H.6
-
95
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, et al. Autophagy regulates lipid metabolism. Nature 2009; 458: 1131-1135.
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
Xiang, Y.4
Novak, I.5
Komatsu, M.6
-
96
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 2010; 11: 467-478.
-
(2010)
Cell Metab
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
Calay, E.S.4
Hotamisligil, G.S.5
-
97
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.
-
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-1465.
-
(2008)
Nat Genet
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
Kozlitina, J.2
Xing, C.3
Pertsemlidis, A.4
Cox, D.5
Pennacchio, L.A.6
-
98
-
-
77950202777
-
Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
-
Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM, et al. Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med 2010; 362: 1082-1089.
-
(2010)
N Engl J Med
, vol.362
, pp. 1082-1089
-
-
Petersen, K.F.1
Dufour, S.2
Hariri, A.3
Nelson-Williams, C.4
Foo, J.N.5
Zhang, X.M.6
-
99
-
-
70350550096
-
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene
-
Kantartzis K, Peter A, Machicao F, Machann J, Wagner S, Konigsrainer I, et al. Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes 2009; 58: 2616-2623.
-
(2009)
Diabetes
, vol.58
, pp. 2616-2623
-
-
Kantartzis, K.1
Peter, A.2
Machicao, F.3
Machann, J.4
Wagner, S.5
Konigsrainer, I.6
-
100
-
-
67349174005
-
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
-
Kotronen A, Johansson LE, Johansson LM, Roos C, Westerbacka J, Hamsten A, et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 2009; 52: 1056-1060.
-
(2009)
Diabetologia
, vol.52
, pp. 1056-1060
-
-
Kotronen, A.1
Johansson, L.E.2
Johansson, L.M.3
Roos, C.4
Westerbacka, J.5
Hamsten, A.6
-
101
-
-
69249111667
-
A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
-
Sookoian S, Castano GO, Burgueno AL, Gianotti TF, Rosselli MS, Pirola CJ. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res 2009; 50: 2111-2116.
-
(2009)
J Lipid Res
, vol.50
, pp. 2111-2116
-
-
Sookoian, S.1
Castano, G.O.2
Burgueno, A.L.3
Gianotti, T.F.4
Rosselli, M.S.5
Pirola, C.J.6
-
102
-
-
77950607738
-
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
-
Valenti L, Al Serri A, Daly AK, Galmozzi E, Rametta R, Dongiovanni P, et al. Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. HEPATOLOGY 2010; 51: 1209-1217.
-
(2010)
HEPATOLOGY
, vol.51
, pp. 1209-1217
-
-
Valenti, L.1
Al Serri, A.2
Daly, A.K.3
Galmozzi, E.4
Rametta, R.5
Dongiovanni, P.6
-
103
-
-
77956636268
-
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
-
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. HEPATOLOGY 2010; 52: 894-903.
-
(2010)
HEPATOLOGY
, vol.52
, pp. 894-903
-
-
Rotman, Y.1
Koh, C.2
Zmuda, J.M.3
Kleiner, D.E.4
Liang, T.J.5
-
104
-
-
77956630787
-
PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.
-
Speliotes EK, Butler JL, Palmer CD, Voight BF, Hirschhorn JN. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. HEPATOLOGY 2010; 52: 904-912.
-
(2010)
HEPATOLOGY
, vol.52
, pp. 904-912
-
-
Speliotes, E.K.1
Butler, J.L.2
Palmer, C.D.3
Voight, B.F.4
Hirschhorn, J.N.5
-
105
-
-
77956625538
-
Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
-
Chen W, Chang B, Li L, Chan L. Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. HEPATOLOGY 2010; 52: 1134-1142.
-
(2010)
HEPATOLOGY
, vol.52
, pp. 1134-1142
-
-
Chen, W.1
Chang, B.2
Li, L.3
Chan, L.4
-
106
-
-
77950251400
-
A human gut microbial gene catalogue established by metagenomic sequencing
-
Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59-65.
-
(2010)
Nature
, vol.464
, pp. 59-65
-
-
Qin, J.1
Li, R.2
Raes, J.3
Arumugam, M.4
Burgdorf, K.S.5
Manichanh, C.6
-
107
-
-
77951874018
-
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
-
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010; 362: 1675-1685.
-
(2010)
N Engl J Med
, vol.362
, pp. 1675-1685
-
-
Sanyal, A.J.1
Chalasani, N.2
Kowdley, K.V.3
McCullough, A.4
Diehl, A.M.5
Bass, N.M.6
-
108
-
-
33846253661
-
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis
-
Ota T, Takamura T, Kurita S, Matsuzawa N, Kita Y, Uno M, et al. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Gastroenterology 2007; 132: 282-293.
-
(2007)
Gastroenterology
, vol.132
, pp. 282-293
-
-
Ota, T.1
Takamura, T.2
Kurita, S.3
Matsuzawa, N.4
Kita, Y.5
Uno, M.6
-
109
-
-
71549135671
-
Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism
-
Landrier JF, Gouranton E, El Yazidi C, Malezet C, Balaguer P, Borel P, et al. Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Endocrinology 2009; 150: 5318-5325.
-
(2009)
Endocrinology
, vol.150
, pp. 5318-5325
-
-
Landrier, J.F.1
Gouranton, E.2
El Yazidi, C.3
Malezet, C.4
Balaguer, P.5
Borel, P.6
-
110
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006; 313: 1137-1140.
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
-
111
-
-
1542515099
-
Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial
-
Lindor KD, Kowdley KV, Heathcote EJ, Harrison ME, Jorgensen R, Angulo P, et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. HEPATOLOGY 2004; 39: 770-778.
-
(2004)
HEPATOLOGY
, vol.39
, pp. 770-778
-
-
Lindor, K.D.1
Kowdley, K.V.2
Heathcote, E.J.3
Harrison, M.E.4
Jorgensen, R.5
Angulo, P.6
-
112
-
-
77955699301
-
High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial
-
Leuschner UF, Lindenthal B, Herrmann G, Arnold JC, Rossle M, Cordes HJ, et al. High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial. HEPATOLOGY 2010; 52: 472-479.
-
(2010)
HEPATOLOGY
, vol.52
, pp. 472-479
-
-
Leuschner, U.F.1
Lindenthal, B.2
Herrmann, G.3
Arnold, J.C.4
Rossle, M.5
Cordes, H.J.6
-
113
-
-
56749164791
-
Nutrient sensing and inflammation in metabolic diseases
-
Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 2008; 8: 923-934.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 923-934
-
-
Hotamisligil, G.S.1
Erbay, E.2
-
114
-
-
77951290227
-
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
-
Martinon F, Chen X, Lee AH, Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 2010; 11: 411-418.
-
(2010)
Nat Immunol
, vol.11
, pp. 411-418
-
-
Martinon, F.1
Chen, X.2
Lee, A.H.3
Glimcher, L.H.4
|