Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin

Life Sciences

Volumn 88, Issue 13-14, 2011, Pages 613-618

  Miyata, Yoshiki ^a   Tanaka, Haruyuki ^a   Shimada, Arata ^a   Sato, Takashi ^b   Ito, Akira ^b   Yamanouchi, Toshikazu ^a   Kosano, Hiroshi ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Adiponectin; Apoptosis; Monocyte chemoattractant protein; Nobiletin; Polymethoxyflavonoid; Resistin; Tangeretin

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; FAT DROPLET; MONOCYTE CHEMOTACTIC PROTEIN 1; NOBILETIN; RESISTIN; TANGERETIN; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CYTOKINE RELEASE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN;

3T3-L1 CELLS; ADIPOCYTES; ADIPOKINES; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL ENLARGEMENT; CHEMOKINE CCL2; CULTURE MEDIA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONES; IN SITU NICK-END LABELING; INSULIN RESISTANCE; MICE; MOLECULAR STRUCTURE; TIME FACTORS; TRIGLYCERIDES;

MURINAE;

EID: 79952700752     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.01.024     Document Type: Article

References (26)

1. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257(1):79-83. (Pubitemid 29299050)
2. Bowen L, Stein PP, Stevenson R, Shulman GI. The effect of CP 68, 722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats. Metabolism 1991;40(10):1025-30.
3. Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT. Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. NeuroReport 2001;12(17):3871-5. (Pubitemid 33105188)
4. Díez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003;148(3):293-300. (Pubitemid 36410714)
5. Green H, Meuth M. An established pre-adipose cell line and its differentiation in culture. Cell 1974;3(2):127-33.
6. Haluzik M, Haluzikova D. The role of resistin in obesity-induced insulin resistance. Curr Opin Investig Drugs 2006;7(4):306-11.
7. Horowitz RM, Gentili B. Flavonoid constituents of citrus. In: Nagy S, Shaw PE, Veldhuis MK, editors. Citrus Science and Technology. Westport, CT: Avi Publishing Company, Inc.; 1977. p. 397-426.
8. Hsu CL, Yen GC. Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes. J Agric Food Chem 2007;55(21):8404-10.
9. Hsu CL, Yen GC. Phenolic compounds: evidence for inhibitory effects against obesity and their underlying molecular signaling mechanisms. Mol Nutr Food Res 2008;52(1):53-61.
10. Jernås M, Palming J, Sjöholm K, Jennische E, Svensson PA, Gabrielsson BG, et al. Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J 2006;20(9):1540-2.
11. Kim CS, Park HS, Kawada T, Kim JH, Lim D, Hubbard NE, et al. Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes Lond 2006;30(9):1347-55. (Pubitemid 44306516)
12. Kopelman PG. Obesity as a medical problem. Nature 2000;404(6778):635-43. (Pubitemid 30205068)
13. Kunimasa K, Kuranuki S, Matsuura N, Iwasaki N, Ikeda M, Ito A, et al. Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion. Bioorg Med Chem Lett 2009;19(7):2062-4.
14. Lin N, Sato T, Takayama Y, Mimaki Y, Sashida Y, Yano M, et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharmacol 2003;65(12):2065-71. (Pubitemid 36629589)
15. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221(2):286-9. (Pubitemid 26136463)
16. Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 1994;331(18):1188-93. (Pubitemid 24331336)
17. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004;279(13):12152-62. (Pubitemid 38445780)
18. Saito T, Abe D, Sekiya K. Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes. Biochem Biophys Res Commun 2007;357(2):371-6. (Pubitemid 46603141)
19. Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 2001;104(4):517-29. (Pubitemid 32201947)
20. Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci USA 2003;100(12):7265-70. (Pubitemid 36706427)
21. Sato T, Koike L, Miyata Y, Hirata M, Mimaki Y, Sashida Y, et al. Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases- 1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells. Cancer Res 2002;62(4):1025-9. (Pubitemid 34160282)
22. 2+- dependent apoptotic targets in adipocytes. J Agric Food Chem 2009;57(13):5771-6.
23. Silalahi J. Anticancer and health protective properties of citrus fruit components. Asia Pac J Clin Nutr 2002;11(1):79-84. (Pubitemid 34875161)
24. Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, et al. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem 2003;278(41):40352-63. (Pubitemid 37248604)
25. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7(8):941-6. (Pubitemid 32756432)
26. Yu JG, Javorschi S, Hevener AL, Kruszynska YT, Norman RA, Sinha M, et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 2002;51(10):2968-74.