-
1
-
-
0003151360
-
Pathophysiology of type II diabetes mellitus
-
Porte D Jr, Sherwin RS (eds). Appleton and Lange, Stamford
-
Kahn SE, Porte D, Jr (1996) Pathophysiology of type II diabetes mellitus. In: Porte D Jr, Sherwin RS (eds) Diabetes mellitus. Appleton and Lange, Stamford, pp 487-512
-
(1996)
Diabetes Mellitus
, pp. 487-512
-
-
Kahn, S.E.1
Porte D., Jr.2
-
2
-
-
0026021161
-
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
-
DeFronzo RA, Ferrannini E (1991) Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194
-
(1991)
Diabetes Care
, vol.14
, pp. 173-194
-
-
DeFronzo, R.A.1
Ferrannini, E.2
-
3
-
-
0030253348
-
Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus
-
Kruszynska YT, Olefsky JM (1996) Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J Investig Med 44:413-428
-
(1996)
J Investig Med
, vol.44
, pp. 413-428
-
-
Kruszynska, Y.T.1
Olefsky, J.M.2
-
4
-
-
0026110135
-
β-cells in type II diabetes mellitus
-
Porte D Jr (1991) β-cells in type II diabetes mellitus. Diabetes 40:166-180
-
(1991)
Diabetes
, vol.40
, pp. 166-180
-
-
Porte D., Jr.1
-
5
-
-
0026602267
-
Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
-
Mitrakou A, Kelley D, Mokan M et al. (1992) Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326:22-29
-
(1992)
N Engl J Med
, vol.326
, pp. 22-29
-
-
Mitrakou, A.1
Kelley, D.2
Mokan, M.3
-
6
-
-
0034853485
-
The importance of beta-cell failure in the development and progression of type 2 diabetes
-
Kahn SE (2001) The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 86:4047-4058
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4047-4058
-
-
Kahn, S.E.1
-
7
-
-
0032162184
-
Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. The evidence report
-
National Heart Lung and Blood Institute (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. The evidence report. Obes Res 6 [Suppl 2]:51S-209S
-
(1998)
Obes Res
, vol.6
, Issue.SUPPL. 2
-
-
-
8
-
-
0031752685
-
Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections
-
King H, Aubert RE, Herman WH (1998) Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21:1414-1431
-
(1998)
Diabetes Care
, vol.21
, pp. 1414-1431
-
-
King, H.1
Aubert, R.E.2
Herman, W.H.3
-
9
-
-
0015781421
-
Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects
-
Olefsky J, Farquhar JW, Reaven G (1973) Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects. Diabetes 22:507-513
-
(1973)
Diabetes
, vol.22
, pp. 507-513
-
-
Olefsky, J.1
Farquhar, J.W.2
Reaven, G.3
-
10
-
-
0023215865
-
Relationship of islet function to insulin action in human obesity
-
Beard JC, Ward WK, Halter JB, Wallum BJ, Porte D Jr (1987) Relationship of islet function to insulin action in human obesity. J Clin Endocrinol Metab 65:59-64
-
(1987)
J Clin Endocrinol Metab
, vol.65
, pp. 59-64
-
-
Beard, J.C.1
Ward, W.K.2
Halter, J.B.3
Wallum, B.J.4
Porte D., Jr.5
-
13
-
-
0037076025
-
Prevalence of impaired glucose tolerance among children and adolescents with marked obesity
-
Sinha R, Fisch G, Teague B et al. (2002) Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346:802-810
-
(2002)
N Engl J Med
, vol.346
, pp. 802-810
-
-
Sinha, R.1
Fisch, G.2
Teague, B.3
-
14
-
-
0032511583
-
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
-
UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837-853
-
(1998)
Lancet
, vol.352
, pp. 837-853
-
-
-
15
-
-
0032983666
-
Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
-
UK Prospective Diabetes Study (UKPDS) Group
-
Turner RC, Cull CA, Frighi V, Holman RR (1999) Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 281:2005-2012
-
(1999)
JAMA
, vol.281
, pp. 2005-2012
-
-
Turner, R.C.1
Cull, C.A.2
Frighi, V.3
Holman, R.R.4
-
16
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
The Diabetes Prevention Program Research Group (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403
-
(2002)
N Engl J Med
, vol.346
, pp. 393-403
-
-
-
17
-
-
0031972156
-
UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years
-
UK Prospective Diabetes Study (UKPDS) Group
-
Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC (1998) UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabet Med 15:297-303
-
(1998)
Diabet Med
, vol.15
, pp. 297-303
-
-
Matthews, D.R.1
Cull, C.A.2
Stratton, I.M.3
Holman, R.R.4
Turner, R.C.5
-
18
-
-
0031823666
-
Assessing the potential for alpha-glucosidase inhibitors in prediabetic states
-
Holman RR (1998) Assessing the potential for alpha-glucosidase inhibitors in prediabetic states. Diabetes Res Clin Pract 40 [Suppl]:S21-S25
-
(1998)
Diabetes Res Clin Pract
, vol.40
, Issue.SUPPL.
-
-
Holman, R.R.1
-
19
-
-
0042570843
-
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
-
Virkamaki A, Ueki K, Kahn CR (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943
-
(1999)
J Clin Invest
, vol.103
, pp. 931-943
-
-
Virkamaki, A.1
Ueki, K.2
Kahn, C.R.3
-
20
-
-
0033599038
-
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
-
Barroso I, Gurnell M, Crowley VE et al. (1999) Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402:880-883
-
(1999)
Nature
, vol.402
, pp. 880-883
-
-
Barroso, I.1
Gurnell, M.2
Crowley, V.E.3
-
21
-
-
0018702014
-
Glucose intolerance of aging. Evidence for tissue insensitivity to insulin
-
DeFronzo RA (1979) Glucose intolerance of aging. Evidence for tissue insensitivity to insulin. Diabetes 28:1095-1101
-
(1979)
Diabetes
, vol.28
, pp. 1095-1101
-
-
DeFronzo, R.A.1
-
22
-
-
0021933723
-
Pathogenesis of age-related glucose intolerance in man: Insulin resistance and decreased β-cell function
-
Chen M, Bergman RN, Pacini G, Porte D Jr (1985) Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased β-cell function. J Clin Endocrinol Metab 60:13-20
-
(1985)
J Clin Endocrinol Metab
, vol.60
, pp. 13-20
-
-
Chen, M.1
Bergman, R.N.2
Pacini, G.3
Porte D., Jr.4
-
23
-
-
0029549608
-
Changes in insulin sensitivity, glucose effectiveness, and B-cell function in regularly exercising subjects
-
Prigeon RL, Kahn SE, Porte D Jr. (1995) Changes in insulin sensitivity, glucose effectiveness, and B-cell function in regularly exercising subjects. Metabolism 44:1259-1263
-
(1995)
Metabolism
, vol.44
, pp. 1259-1263
-
-
Prigeon, R.L.1
Kahn, S.E.2
Porte D., Jr.3
-
24
-
-
0025297306
-
Effect of exercise on insulin action, glucose tolerance and insulin secretion in aging
-
Kahn SE, Larson VG, Beard JC et al. (1990) Effect of exercise on insulin action, glucose tolerance and insulin secretion in aging. Am J Physiol 258:E937-E943
-
(1990)
Am J Physiol
, vol.258
-
-
Kahn, S.E.1
Larson, V.G.2
Beard, J.C.3
-
25
-
-
0023177870
-
The role of dietary carbohydrate in the decreased glucose tolerance of the elderly
-
Chen M, Halter JB, Porte D Jr (1987) The role of dietary carbohydrate in the decreased glucose tolerance of the elderly. J Am Geriatr Soc 35:417-424
-
(1987)
J Am Geriatr Soc
, vol.35
, pp. 417-424
-
-
Chen, M.1
Halter, J.B.2
Porte D., Jr.3
-
26
-
-
0021522787
-
Dexamethasone-induced insulin resistance enhances B-cell responsiveness to glucose level in normal men
-
Beard JC, Halter JB, Best JD, Pfeifer MA, Porte D Jr (1984) Dexamethasone-induced insulin resistance enhances B-cell responsiveness to glucose level in normal men. Am J Physiol 247:E592-E596
-
(1984)
Am J Physiol
, vol.247
-
-
Beard, J.C.1
Halter, J.B.2
Best, J.D.3
Pfeifer, M.A.4
Porte D., Jr.5
-
27
-
-
0019970112
-
Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization
-
Rizza RA, Mandarino LJ, Gerich JE (1982) Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 31:663-669
-
(1982)
Diabetes
, vol.31
, pp. 663-669
-
-
Rizza, R.A.1
Mandarino, L.J.2
Gerich, J.E.3
-
28
-
-
0024538602
-
Increased β-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance
-
Kahn SE, Beard JC, Schwartz MW et al. (1989) Increased β-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes 38:562-568
-
(1989)
Diabetes
, vol.38
, pp. 562-568
-
-
Kahn, S.E.1
Beard, J.C.2
Schwartz, M.W.3
-
29
-
-
0018896297
-
Mechanisms of insulin resistance in human obesity: Evidence for receptor and postreceptor defects
-
Kolterman OG, Insel J, Saekow M, Olefsky JM (1980) Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects. J Clin Invest 65:1272-1284
-
(1980)
J Clin Invest
, vol.65
, pp. 1272-1284
-
-
Kolterman, O.G.1
Insel, J.2
Saekow, M.3
Olefsky, J.M.4
-
30
-
-
0023811760
-
Obesity and insulin resistance: Lessons learned from the Pima Indians
-
Lillioja S, Bogardus C (1988) Obesity and insulin resistance: lessons learned from the Pima Indians. Diabetes Metab Rev 4:517-540
-
(1988)
Diabetes Metab Rev
, vol.4
, pp. 517-540
-
-
Lillioja, S.1
Bogardus, C.2
-
31
-
-
33644822875
-
Visceral obesity: A "civilization syndrome"
-
Bjorntorp P (1993) Visceral obesity: a "civilization syndrome". Obes Res 1:206-222
-
(1993)
Obes Res
, vol.1
, pp. 206-222
-
-
Bjorntorp, P.1
-
32
-
-
0022846676
-
Splanchnic insulin metabolism in obesity. Influence of body fat distribution
-
Peiris AN, Mueller RA, Smith GA, Struve MF, Kissebah AH (1986) Splanchnic insulin metabolism in obesity. Influence of body fat distribution. J Clin Invest 78:1648-1657
-
(1986)
J Clin Invest
, vol.78
, pp. 1648-1657
-
-
Peiris, A.N.1
Mueller, R.A.2
Smith, G.A.3
Struve, M.F.4
Kissebah, A.H.5
-
33
-
-
0026741762
-
Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels
-
Pouliot MC, Despres JP, Nadeau A et al. (1992) Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes 41:826-834
-
(1992)
Diabetes
, vol.41
, pp. 826-834
-
-
Pouliot, M.C.1
Despres, J.P.2
Nadeau, A.3
-
34
-
-
0024383925
-
Relative contribution of obesity and body fat distribution to alterations in glucose insulin homeostasis: Predictive values of selected indices in premenopausal women
-
Peiris AN, Sothmann MS, Hennes MI et al. (1989) Relative contribution of obesity and body fat distribution to alterations in glucose insulin homeostasis: predictive values of selected indices in premenopausal women. Am J Clin Nutr 49:758-764
-
(1989)
Am J Clin Nutr
, vol.49
, pp. 758-764
-
-
Peiris, A.N.1
Sothmann, M.S.2
Hennes, M.I.3
-
35
-
-
0001021348
-
The visceral adiposity syndrome in Japanese-American men
-
Fujimoto WY, Abbate SL, Kahn SE, Hokanson JE, Brunzell JD (1994) The visceral adiposity syndrome in Japanese-American men. Obes Res 2:364-371
-
(1994)
Obes Res
, vol.2
, pp. 364-371
-
-
Fujimoto, W.Y.1
Abbate, S.L.2
Kahn, S.E.3
Hokanson, J.E.4
Brunzell, J.D.5
-
36
-
-
0029087640
-
Relationships of generalized and regional adiposity to insulin sensitivity in men
-
Abate N, Garg A, Peshock RM, Stray-Gundersen J, Grundy SM (1995) Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 96:88-98
-
(1995)
J Clin Invest
, vol.96
, pp. 88-98
-
-
Abate, N.1
Garg, A.2
Peshock, R.M.3
Stray-Gundersen, J.4
Grundy, S.M.5
-
37
-
-
0033054725
-
Effects of weight loss on regional fat distribution and insulin sensitivity in obesity
-
Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL (1999) Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48:839-847
-
(1999)
Diabetes
, vol.48
, pp. 839-847
-
-
Goodpaster, B.H.1
Kelley, D.E.2
Wing, R.R.3
Meier, A.4
Thaete, F.L.5
-
38
-
-
0036228581
-
The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: Distinct metabolic effects of two fat compartments
-
Cnop M, Landchild MJ, Vidal J et al. (2002) The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 51:1005-1015
-
(2002)
Diabetes
, vol.51
, pp. 1005-1015
-
-
Cnop, M.1
Landchild, M.J.2
Vidal, J.3
-
39
-
-
0026761432
-
Mutations in the insulin receptor gene
-
Taylor SI, Cama A, Accili D et al. (1992) Mutations in the insulin receptor gene. Endocr Rev 13:566-595
-
(1992)
Endocr Rev
, vol.13
, pp. 566-595
-
-
Taylor, S.I.1
Cama, A.2
Accili, D.3
-
40
-
-
0031688058
-
A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes
-
Xia J, Scherer SW, Cohen PT et al. (1998) A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. Diabetes 47:1519-1524
-
(1998)
Diabetes
, vol.47
, pp. 1519-1524
-
-
Xia, J.1
Scherer, S.W.2
Cohen, P.T.3
-
41
-
-
0031763878
-
Variation in the AU(AT)-rich element within the 3′-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
-
Hegele RA, Harris SB, Zinman B et al. (1998) Variation in the AU(AT)-rich element within the 3′-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians. J Clin Endocrinol Metab 83:3980-3983
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 3980-3983
-
-
Hegele, R.A.1
Harris, S.B.2
Zinman, B.3
-
42
-
-
0029126604
-
A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin
-
Hansen L, Hansen T, Vestergaard H et al. (1995) A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hum Mol Genet 4:1313-1320
-
(1995)
Hum Mol Genet
, vol.4
, pp. 1313-1320
-
-
Hansen, L.1
Hansen, T.2
Vestergaard, H.3
-
43
-
-
0033956880
-
Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity
-
Hansen L, Reneland R, Berglund L et al. (2000) Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity. Diabetes 49:298-301
-
(2000)
Diabetes
, vol.49
, pp. 298-301
-
-
Hansen, L.1
Reneland, R.2
Berglund, L.3
-
44
-
-
0036091918
-
Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: Interaction with family history of type 2 diabetes
-
Stumvoll M, Tschritter O, Fritsche A et al. (2002) Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 51:37-41
-
(2002)
Diabetes
, vol.51
, pp. 37-41
-
-
Stumvoll, M.1
Tschritter, O.2
Fritsche, A.3
-
45
-
-
0035093082
-
Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds
-
Hasstedt SJ, Ren QF, Teng K, Elbein SC (2001) Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds. J Clin Endocrinol Metab 86:536-541
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 536-541
-
-
Hasstedt, S.J.1
Ren, Q.F.2
Teng, K.3
Elbein, S.C.4
-
46
-
-
0031595923
-
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
-
Deeb SS, Fajas L, Nemoto M et al. (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20:284-287
-
(1998)
Nat Genet
, vol.20
, pp. 284-287
-
-
Deeb, S.S.1
Fajas, L.2
Nemoto, M.3
-
47
-
-
0033624575
-
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
Altshuler D, Hirschhorn JN, Klannemark M et al. (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80
-
(2000)
Nat Genet
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
Hirschhorn, J.N.2
Klannemark, M.3
-
48
-
-
0022496323
-
Exercise and physical training: Effects on insulin sensitivity and glucose metabolism
-
Horton ES (1986) Exercise and physical training: effects on insulin sensitivity and glucose metabolism. Diabetes Metab Rev 2:1-17
-
(1986)
Diabetes Metab Rev
, vol.2
, pp. 1-17
-
-
Horton, E.S.1
-
49
-
-
0023792352
-
Insulin resistance and β-cell dysfunction in aging: The importance of dietary carbohydrate
-
Chen M, Bergman RN, Porte D Jr (1988) Insulin resistance and β-cell dysfunction in aging: the importance of dietary carbohydrate. J Clin Endocrinol Metab 67:951-957
-
(1988)
J Clin Endocrinol Metab
, vol.67
, pp. 951-957
-
-
Chen, M.1
Bergman, R.N.2
Porte D., Jr.3
-
50
-
-
0015219449
-
Improved glucose tolerance with high carbohydrate feeding in mild diabetes
-
Brunzell JD, Lerner RL, Hazzard WR, Porte D Jr, Bierman EL (1971) Improved glucose tolerance with high carbohydrate feeding in mild diabetes. N Engl J Med 284:521-524
-
(1971)
N Engl J Med
, vol.284
, pp. 521-524
-
-
Brunzell, J.D.1
Lerner, R.L.2
Hazzard, W.R.3
Porte D., Jr.4
Bierman, E.L.5
-
51
-
-
0025300496
-
Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease
-
Despres JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C (1990) Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 10:497-511
-
(1990)
Arteriosclerosis
, vol.10
, pp. 497-511
-
-
Despres, J.P.1
Moorjani, S.2
Lupien, P.J.3
Tremblay, A.4
Nadeau, A.5
Bouchard, C.6
-
52
-
-
0024343365
-
Adiposity, fat distribution, and cardiovascular risk
-
Peiris AN, Sothmann MS, Hoffmann RG et al. (1989) Adiposity, fat distribution, and cardiovascular risk. Ann Intern Med 110:867-872
-
(1989)
Ann Intern Med
, vol.110
, pp. 867-872
-
-
Peiris, A.N.1
Sothmann, M.S.2
Hoffmann, R.G.3
-
53
-
-
0029862540
-
Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM
-
Abate N, Garg A, Peshock RM, Stray-Gundersen J, Adams-Huet B, Grundy SM (1996) Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes 45:1684-1693
-
(1996)
Diabetes
, vol.45
, pp. 1684-1693
-
-
Abate, N.1
Garg, A.2
Peshock, R.M.3
Stray-Gundersen, J.4
Adams-Huet, B.5
Grundy, S.M.6
-
54
-
-
0027375768
-
Quantification of the relationship between insulin sensitivity and B-cell function in human subjects. Evidence for a hyperbolic function
-
Kahn SE, Prigeon RL, McCulloch DK et al. (1993) Quantification of the relationship between insulin sensitivity and B-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42:1663-1672
-
(1993)
Diabetes
, vol.42
, pp. 1663-1672
-
-
Kahn, S.E.1
Prigeon, R.L.2
McCulloch, D.K.3
-
55
-
-
0000033848
-
Gender-based differences in adiponectin and leptin levels are related to differences in body fat distribution
-
Abstract
-
Cnop M, Havel PJ, Utzschneider KM et al. (2002) Gender-based differences in adiponectin and leptin levels are related to differences in body fat distribution. Diabetes 50 [Suppl 2]:A404 (Abstract)
-
(2002)
Diabetes
, vol.50
, Issue.SUPPL. 2
-
-
Cnop, M.1
Havel, P.J.2
Utzschneider, K.M.3
-
56
-
-
0032779351
-
Molecular mechanism of metabolic syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances
-
Matsuzawa Y, Funahashi T, Nakamura T (1999) Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann NY Acad Sci 892:146-154
-
(1999)
Ann NY Acad Sci
, vol.892
, pp. 146-154
-
-
Matsuzawa, Y.1
Funahashi, T.2
Nakamura, T.3
-
57
-
-
0034999667
-
Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
-
Weyer C, Funahashi T, Tanaka S et al. (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 1930-1935
-
-
Weyer, C.1
Funahashi, T.2
Tanaka, S.3
-
58
-
-
0034096988
-
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
-
Hotta K, Funahashi T, Arita Y et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 1595-1599
-
-
Hotta, K.1
Funahashi, T.2
Arita, Y.3
-
59
-
-
0030768120
-
Plasma leptin concentrations: Gender differences and associations with metabolic risk factors for cardiovascular disease
-
Couillard C, Mauriege P, Prud'homme D et al. (1997) Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia 40:1178-1184
-
(1997)
Diabetologia
, vol.40
, pp. 1178-1184
-
-
Couillard, C.1
Mauriege, P.2
Prud'homme, D.3
-
61
-
-
0034454766
-
Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men
-
Purnell JQ, Kahn SE, Albers JJ, Nevin DN, Brunzell JD, Schwartz RS (2000) Effect of weight loss with reduction of intra-abdominal fat on lipid metabolism in older men. J Clin Endocrinol Metab 85:977-982
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 977-982
-
-
Purnell, J.Q.1
Kahn, S.E.2
Albers, J.J.3
Nevin, D.N.4
Brunzell, J.D.5
Schwartz, R.S.6
-
62
-
-
0025752437
-
The effect of intensive endurance exercise training on body fat distribution in young and older men
-
Schwartz RS, Shuman WP, Larson V et al. (1991) The effect of intensive endurance exercise training on body fat distribution in young and older men. Metabolism 40:545-551
-
(1991)
Metabolism
, vol.40
, pp. 545-551
-
-
Schwartz, R.S.1
Shuman, W.P.2
Larson, V.3
-
63
-
-
0032588487
-
PPARgamma, the ultimate thrifty gene
-
Auwerx J (1999) PPARgamma, the ultimate thrifty gene. Diabetologia 42:1033-1049
-
(1999)
Diabetologia
, vol.42
, pp. 1033-1049
-
-
Auwerx, J.1
-
64
-
-
0036125944
-
Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
-
Hirose H, Kawai T, Yamamoto Y et al. (2002) Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes. Metabolism 51:314-317
-
(2002)
Metabolism
, vol.51
, pp. 314-317
-
-
Hirose, H.1
Kawai, T.2
Yamamoto, Y.3
-
65
-
-
0032969421
-
Effect of troglitazone on body fat distribution in type 2 diabetic patients
-
Mori Y, Murakawa Y, Okada K et al. (1999) Effect of troglitazone on body fat distribution in type 2 diabetic patients. Diabetes Care 22:908-912
-
(1999)
Diabetes Care
, vol.22
, pp. 908-912
-
-
Mori, Y.1
Murakawa, Y.2
Okada, K.3
-
66
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
Steppan CM, Bailey ST, Bhat S et al. (2001) The hormone resistin links obesity to diabetes. Nature 409:307-312
-
(2001)
Nature
, vol.409
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
-
67
-
-
0036481709
-
Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients
-
Yang WS, Jeng CY, Wu TJ et al. (2002) Synthetic peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care 25:376-380
-
(2002)
Diabetes Care
, vol.25
, pp. 376-380
-
-
Yang, W.S.1
Jeng, C.Y.2
Wu, T.J.3
-
68
-
-
0014188893
-
Plasma insulin responses to oral and intravenous glucose: Studies in normal and diabetic subjects
-
Perley MJ, Kipnis DM (1967) Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 46:1954-1962
-
(1967)
J Clin Invest
, vol.46
, pp. 1954-1962
-
-
Perley, M.J.1
Kipnis, D.M.2
-
69
-
-
0014142582
-
The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects
-
Bagdade JD, Bierman EL, Porte D Jr (1967) The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J Clin Invest 46:1549-1557
-
(1967)
J Clin Invest
, vol.46
, pp. 1549-1557
-
-
Bagdade, J.D.1
Bierman, E.L.2
Porte D., Jr.3
-
70
-
-
0017236889
-
Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests
-
Brunzell JD, Robertson RP, Lerner RL et al. (1976) Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J Clin Endocrinol Metab 42:222-229
-
(1976)
J Clin Endocrinol Metab
, vol.42
, pp. 222-229
-
-
Brunzell, J.D.1
Robertson, R.P.2
Lerner, R.L.3
-
71
-
-
0021751981
-
Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
-
Ward WK, Bolgiano DC, McKnight B, Halter JB, Porte D Jr (1984) Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Invest 74:1318-1328
-
(1984)
J Clin Invest
, vol.74
, pp. 1318-1328
-
-
Ward, W.K.1
Bolgiano, D.C.2
McKnight, B.3
Halter, J.B.4
Porte D., Jr.5
-
72
-
-
0018098013
-
Mechanisms of impaired acute insulin release in adult onset diabetes: Studies with isoproterenol and secretin
-
Halter JB, Porte D Jr (1978) Mechanisms of impaired acute insulin release in adult onset diabetes: studies with isoproterenol and secretin. J Clin Endocrinol Metab 46:952-960
-
(1978)
J Clin Endocrinol Metab
, vol.46
, pp. 952-960
-
-
Halter, J.B.1
Porte D., Jr.2
-
73
-
-
0014806303
-
Early insulin responses to glucose and to tolbutamide in maturity-onset diabetes
-
Varsano-Aharon N, Echemendia E, Yalow RS, Berson SA (1970) Early insulin responses to glucose and to tolbutamide in maturity-onset diabetes. Metabolism 19:409-417
-
(1970)
Metabolism
, vol.19
, pp. 409-417
-
-
Varsano-Aharon, N.1
Echemendia, E.2
Yalow, R.S.3
Berson, S.A.4
-
74
-
-
0023951171
-
Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes
-
O'Rahilly S, Turner RC, Matthews DR (1988) Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 318:1225-1230
-
(1988)
N Engl J Med
, vol.318
, pp. 1225-1230
-
-
O'Rahilly, S.1
Turner, R.C.2
Matthews, D.R.3
-
75
-
-
0011648510
-
The in vivo regulation of pulsatile insulin secretion
-
Porksen N (2002) The in vivo regulation of pulsatile insulin secretion. Diabetologia 45:3-20
-
(2002)
Diabetologia
, vol.45
, pp. 3-20
-
-
Porksen, N.1
-
76
-
-
0023916553
-
Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus
-
Polonsky KS, Given BD, Hirsch LJ et al. (1988) Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 318:1231-1239
-
(1988)
N Engl J Med
, vol.318
, pp. 1231-1239
-
-
Polonsky, K.S.1
Given, B.D.2
Hirsch, L.J.3
-
77
-
-
0017761172
-
Circulating proinsulin in patients with maturity-onset diabetes
-
Mako ME, Starr JI, Rubenstein AH (1977) Circulating proinsulin in patients with maturity-onset diabetes. Am J Med 63:865-869
-
(1977)
Am J Med
, vol.63
, pp. 865-869
-
-
Mako, M.E.1
Starr, J.I.2
Rubenstein, A.H.3
-
78
-
-
0023634652
-
Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and experimental insulin resistance
-
Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte D Jr (1987) Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and experimental insulin resistance. Diabetologia 30:698-702
-
(1987)
Diabetologia
, vol.30
, pp. 698-702
-
-
Ward, W.K.1
LaCava, E.C.2
Paquette, T.L.3
Beard, J.C.4
Wallum, B.J.5
Porte D., Jr.6
-
79
-
-
0023759449
-
Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus
-
Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y (1988) Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 31:355-360
-
(1988)
Diabetologia
, vol.31
, pp. 355-360
-
-
Yoshioka, N.1
Kuzuya, T.2
Matsuda, A.3
Taniguchi, M.4
Iwamoto, Y.5
-
80
-
-
0025292213
-
Radioimmunoassay may overestimate insulin in non-insulin-dependent diabetics
-
Temple RC, Clark PM, Nagi DK, Schneider AE, Yudkin JS, Hales CN (1990) Radioimmunoassay may overestimate insulin in non-insulin-dependent diabetics. Clin Endocrinol (Oxf) 32:689-693
-
(1990)
Clin Endocrinol (Oxf)
, vol.32
, pp. 689-693
-
-
Temple, R.C.1
Clark, P.M.2
Nagi, D.K.3
Schneider, A.E.4
Yudkin, J.S.5
Hales, C.N.6
-
81
-
-
0025268864
-
Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus
-
Saad MF, Kahn SE, Nelson RG et al. (1990) Disproportionately elevated proinsulin in Pima Indians with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 70:1247-1253
-
(1990)
J Clin Endocrinol Metab
, vol.70
, pp. 1247-1253
-
-
Saad, M.F.1
Kahn, S.E.2
Nelson, R.G.3
-
82
-
-
0028967995
-
Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese American men: Impact of obesity
-
Kahn SE, Leonetti DL, Prigeon RL, Bergstrom RW, Fujimoto WY (1995) Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese American men: impact of obesity. J Clin Endocrinol Metab 80:1399-1406
-
(1995)
J Clin Endocrinol Metab
, vol.80
, pp. 1399-1406
-
-
Kahn, S.E.1
Leonetti, D.L.2
Prigeon, R.L.3
Bergstrom, R.W.4
Fujimoto, W.Y.5
-
83
-
-
0030662718
-
Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM
-
Kahn SE, Halban PA (1997) Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 46:1725-1732
-
(1997)
Diabetes
, vol.46
, pp. 1725-1732
-
-
Kahn, S.E.1
Halban, P.A.2
-
84
-
-
0025967810
-
Plasma islet amyloid polypeptide (amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients
-
Sanke T, Hanabusa T, Nakano Y et al. (1991) Plasma islet amyloid polypeptide (amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 34:129-132
-
(1991)
Diabetologia
, vol.34
, pp. 129-132
-
-
Sanke, T.1
Hanabusa, T.2
Nakano, Y.3
-
85
-
-
0026317392
-
Decrease of stimulated amylin release precedes impairment of insulin secretion in type II diabetes
-
Ludvik B, Lell B, Hartter E, Schnack C, Prager R (1991) Decrease of stimulated amylin release precedes impairment of insulin secretion in type II diabetes. Diabetes 40:1615-1619
-
(1991)
Diabetes
, vol.40
, pp. 1615-1619
-
-
Ludvik, B.1
Lell, B.2
Hartter, E.3
Schnack, C.4
Prager, R.5
-
86
-
-
0026512386
-
Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus
-
Enoki S, Mitsukawa T, Takemura J et al. (1992) Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 15:97-102
-
(1992)
Diabetes Res Clin Pract
, vol.15
, pp. 97-102
-
-
Enoki, S.1
Mitsukawa, T.2
Takemura, J.3
-
87
-
-
0031895880
-
Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans
-
Kahn SE, Verchere CB, Andrikopoulos S et al. (1998) Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans. Diabetes 47:640-645
-
(1998)
Diabetes
, vol.47
, pp. 640-645
-
-
Kahn, S.E.1
Verchere, C.B.2
Andrikopoulos, S.3
-
88
-
-
0036306096
-
β-cell function is the major determinant of oral glucose tolerance in four ethnic groups in the United States
-
Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE, American Diabetes Association GENNID Study Group (2002) β-cell function is the major determinant of oral glucose tolerance in four ethnic groups in the United States. Diabetes 51:2170-2178
-
(2002)
Diabetes
, vol.51
, pp. 2170-2178
-
-
Jensen, C.C.1
Cnop, M.2
Hull, R.L.3
Fujimoto, W.Y.4
Kahn, S.E.5
-
89
-
-
0001256804
-
Plasma insulin concentrations in nondiabetic and early diabetic subjects: Determinations by a new sensitive immunoassay technic
-
Yalow RS, Berson SA (1960) Plasma insulin concentrations in nondiabetic and early diabetic subjects: determinations by a new sensitive immunoassay technic. Diabetes 9:254-260
-
(1960)
Diabetes
, vol.9
, pp. 254-260
-
-
Yalow, R.S.1
Berson, S.A.2
-
90
-
-
0021636730
-
Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus
-
Ward WK, Beard JC, Halter JB, Pfeifer MA, Porte D Jr (1984) Pathophysiology of insulin secretion in non-insulin-dependent diabetes mellitus. Diabetes Care 7:491-502
-
(1984)
Diabetes Care
, vol.7
, pp. 491-502
-
-
Ward, W.K.1
Beard, J.C.2
Halter, J.B.3
Pfeifer, M.A.4
Porte D., Jr.5
-
91
-
-
78651132915
-
Excessive insulin response to glucose in obese subjects as measured by immunochemical assay
-
Karam JH, Grodsky GM, Forsham PH (1963) Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. Diabetes 12:197-204
-
(1963)
Diabetes
, vol.12
, pp. 197-204
-
-
Karam, J.H.1
Grodsky, G.M.2
Forsham, P.H.3
-
92
-
-
0016380138
-
Basal and stimulated hyperinsulinism: Reversible metabolic sequelae of obesity
-
Bagdade JD, Porte D Jr, Brunzell JD, Bierman EL (1974) Basal and stimulated hyperinsulinism: reversible metabolic sequelae of obesity. J Lab Clin Med 83:563-569
-
(1974)
J Lab Clin Med
, vol.83
, pp. 563-569
-
-
Bagdade, J.D.1
Porte D., Jr.2
Brunzell, J.D.3
Bierman, E.L.4
-
93
-
-
0019810028
-
Physiologic evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and β-cell glucose sensitivity from the response to intravenous glucose
-
Bergman RN, Phillips LS, Cobelli C (1981) Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and β-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68:1456-1467
-
(1981)
J Clin Invest
, vol.68
, pp. 1456-1467
-
-
Bergman, R.N.1
Phillips, L.S.2
Cobelli, C.3
-
94
-
-
0029775612
-
Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors
-
Clausen JO, Borch-Johnsen K, Ibsen H et al. (1996) Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. J Clin Invest 98:1195-1209
-
(1996)
J Clin Invest
, vol.98
, pp. 1195-1209
-
-
Clausen, J.O.1
Borch-Johnsen, K.2
Ibsen, H.3
-
95
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
-
Weyer C, Bogardus C, Mott DM, Pratley RE (1999) The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
96
-
-
0029092780
-
Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus
-
Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS (1995) Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 96:520-527
-
(1995)
J Clin Invest
, vol.96
, pp. 520-527
-
-
Ehrmann, D.A.1
Sturis, J.2
Byrne, M.M.3
Karrison, T.4
Rosenfield, R.L.5
Polonsky, K.S.6
-
97
-
-
0030459185
-
Regulation of B-cell function in vivo: From health to disease
-
Kahn SE (1996) Regulation of B-cell function in vivo: from health to disease. Diabetes Rev 4:372-389
-
(1996)
Diabetes Rev
, vol.4
, pp. 372-389
-
-
Kahn, S.E.1
-
98
-
-
0033960006
-
Reduced β-cell compensation to the insulin resistance associated with obesity in members of Caucasian familial type 2 diabetic kindreds
-
Elbein SC, Wegner K, Kahn SE (2000) Reduced β-cell compensation to the insulin resistance associated with obesity in members of Caucasian familial type 2 diabetic kindreds. Diabetes Care 23:221-227
-
(2000)
Diabetes Care
, vol.23
, pp. 221-227
-
-
Elbein, S.C.1
Wegner, K.2
Kahn, S.E.3
-
99
-
-
0021850196
-
Insulin resistance and impaired insulin secretion in subjects with histories of gestational diabetes mellitus
-
Ward WK, Johnston CLW, Beard JC, Benedetti TJ, Halter JB, Porte D Jr (1985) Insulin resistance and impaired insulin secretion in subjects with histories of gestational diabetes mellitus. Diabetes 34:861-869
-
(1985)
Diabetes
, vol.34
, pp. 861-869
-
-
Ward, W.K.1
Johnston, C.L.W.2
Beard, J.C.3
Benedetti, T.J.4
Halter, J.B.5
Porte D., Jr.6
-
100
-
-
0029001526
-
Defects in insulin secretion and action in women with a history of gestational diabetes
-
Ryan EA, Imes S, Liu D et al. (1995). Defects in insulin secretion and action in women with a history of gestational diabetes. Diabetes 44:506-512
-
(1995)
Diabetes
, vol.44
, pp. 506-512
-
-
Ryan, E.A.1
Imes, S.2
Liu, D.3
-
101
-
-
0033499585
-
Antepartum predictors of the development of type 2 diabetes in Latino women 11-26 months after pregnancies complicated by gestational diabetes
-
Buchanan TA, Xiang AH, Kjos SL, Trigo E, Lee WP, Peters RK (1999) Antepartum predictors of the development of type 2 diabetes in Latino women 11-26 months after pregnancies complicated by gestational diabetes. Diabetes 48:2430-2436
-
(1999)
Diabetes
, vol.48
, pp. 2430-2436
-
-
Buchanan, T.A.1
Xiang, A.H.2
Kjos, S.L.3
Trigo, E.4
Lee, W.P.5
Peters, R.K.6
-
102
-
-
0029880488
-
Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome
-
Dunaif A, Finegood DT (1996) Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 81:942-947
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 942-947
-
-
Dunaif, A.1
Finegood, D.T.2
-
103
-
-
0026689796
-
Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging
-
Kahn SE, Larson VG, Schwartz RS et al. (1992) Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging. J Clin Endocrinol Metab 74:1336-1342
-
(1992)
J Clin Endocrinol Metab
, vol.74
, pp. 1336-1342
-
-
Kahn, S.E.1
Larson, V.G.2
Schwartz, R.S.3
-
104
-
-
0029962983
-
Islet dysfunction in obese women with impaired glucose tolerance
-
Larsson H, Ahren B (1996) Islet dysfunction in obese women with impaired glucose tolerance. Metabolism 45:502-509
-
(1996)
Metabolism
, vol.45
, pp. 502-509
-
-
Larsson, H.1
Ahren, B.2
-
105
-
-
0030762562
-
Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance
-
Cavaghan MK, Ehrmann DA, Byrne MM, Polonsky KS (1997) Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance. J Clin Invest 100:530-537
-
(1997)
J Clin Invest
, vol.100
, pp. 530-537
-
-
Cavaghan, M.K.1
Ehrmann, D.A.2
Byrne, M.M.3
Polonsky, K.S.4
-
106
-
-
0036483682
-
Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes
-
Knowles NG, Landchild MA, Fujimoto WY, Kahn SE (2002) Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes. Diabetes Care 25:292-297
-
(2002)
Diabetes Care
, vol.25
, pp. 292-297
-
-
Knowles, N.G.1
Landchild, M.A.2
Fujimoto, W.Y.3
Kahn, S.E.4
-
107
-
-
0033312608
-
Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds
-
Elbein SC, Hasstedt SJ, Wegner K, Kahn SE (1999) Heritability of pancreatic beta-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds. J Clin Endocrinol Metab 84:1398-1403
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1398-1403
-
-
Elbein, S.C.1
Hasstedt, S.J.2
Wegner, K.3
Kahn, S.E.4
-
108
-
-
0024246842
-
Increased insulin concentrations in nondiabetic offspring of diabetic parents
-
Haffner S, Stern M, Hazuda H, Mitchell B, Patterson J (1988) Increased insulin concentrations in nondiabetic offspring of diabetic parents. N Engl J Med 319:1297-1301
-
(1988)
N Engl J Med
, vol.319
, pp. 1297-1301
-
-
Haffner, S.1
Stern, M.2
Hazuda, H.3
Mitchell, B.4
Patterson, J.5
-
109
-
-
0023924773
-
Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians
-
Lillioja S, Mott DM, Howard BV et al. (1988) Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. N Engl J Med 318:1217-1225
-
(1988)
N Engl J Med
, vol.318
, pp. 1217-1225
-
-
Lillioja, S.1
Mott, D.M.2
Howard, B.V.3
-
110
-
-
0025663581
-
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
-
Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR (1990) Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:909-915
-
(1990)
Ann Intern Med
, vol.113
, pp. 909-915
-
-
Warram, J.H.1
Martin, B.C.2
Krolewski, A.S.3
Soeldner, J.S.4
Kahn, C.R.5
-
111
-
-
0026793446
-
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
-
Martin BL, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR (1992) Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 340:925-929
-
(1992)
Lancet
, vol.340
, pp. 925-929
-
-
Martin, B.L.1
Warram, J.H.2
Krolewski, A.S.3
Bergman, R.N.4
Soeldner, J.S.5
Kahn, C.R.6
-
112
-
-
0024348996
-
Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
-
Eriksson J, Franssila Kallunki A, Ekstrand A et al. (1989) Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337-343
-
(1989)
N Engl J Med
, vol.321
, pp. 337-343
-
-
Eriksson, J.1
Franssila Kallunki, A.2
Ekstrand, A.3
-
113
-
-
0027762766
-
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
-
Lillioja S, Mott DM, Spraul M et al. (1993) Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 329:1988-1992
-
(1993)
N Engl J Med
, vol.329
, pp. 1988-1992
-
-
Lillioja, S.1
Mott, D.M.2
Spraul, M.3
-
114
-
-
0032456709
-
Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: Problems and prospects
-
Ferrannini E (1998) Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 19:477-490
-
(1998)
Endocr Rev
, vol.19
, pp. 477-490
-
-
Ferrannini, E.1
-
115
-
-
0024307842
-
Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets
-
Lukinius A, Wilander E, Westermark GT, Engstrom U, Westermark P (1989) Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia 32:240-244
-
(1989)
Diabetologia
, vol.32
, pp. 240-244
-
-
Lukinius, A.1
Wilander, E.2
Westermark, G.T.3
Engstrom, U.4
Westermark, P.5
-
116
-
-
0025302287
-
Evidence of cosecretion of islet amyloid polypeptide and insulin by β-cells
-
Kahn SE, D'Alessio DA, Schwartz MW et al. (1990) Evidence of cosecretion of islet amyloid polypeptide and insulin by β-cells. Diabetes 39:634-638
-
(1990)
Diabetes
, vol.39
, pp. 634-638
-
-
Kahn, S.E.1
D'Alessio, D.A.2
Schwartz, M.W.3
-
117
-
-
0026355934
-
Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell
-
Kahn SE, Fujimoto WY, D'Alessio DA, Ensinck JW, Porte D Jr (1991) Glucose stimulates and potentiates islet amyloid polypeptide secretion by the B-cell. Horm Metab Res 23:577-580
-
(1991)
Horm Metab Res
, vol.23
, pp. 577-580
-
-
Kahn, S.E.1
Fujimoto, W.Y.2
D'Alessio, D.A.3
Ensinck, J.W.4
Porte D., Jr.5
-
119
-
-
0029023741
-
Effects of arginine on the secretion of insulin and islet amyloid polypeptide in humans
-
Larsson H, Ahren B (1995) Effects of arginine on the secretion of insulin and islet amyloid polypeptide in humans. Pancreas 11:201-205
-
(1995)
Pancreas
, vol.11
, pp. 201-205
-
-
Larsson, H.1
Ahren, B.2
-
120
-
-
0002567172
-
Increased β-cell secretory demand is not the simple explanation for inefficient proinsulin processing and islet amyloid formation in type 2 diabetes
-
Abstract
-
Landchild MJ, Knowles NG, Yao Q et al. (2000) Increased β-cell secretory demand is not the simple explanation for inefficient proinsulin processing and islet amyloid formation in type 2 diabetes. J Investig Med 48:21A (Abstract)
-
(2000)
J Investig Med
, vol.48
-
-
Landchild, M.J.1
Knowles, N.G.2
Yao, Q.3
-
121
-
-
0029022819
-
Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
-
Pimenta W, Korytkowski M, Mitrakou A et al. (1995) Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA 273:1855-1861
-
(1995)
JAMA
, vol.273
, pp. 1855-1861
-
-
Pimenta, W.1
Korytkowski, M.2
Mitrakou, A.3
-
122
-
-
0030955017
-
Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM
-
Schmitz O, Porksen N, Nyholm B et al. (1997) Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM. Am J Physiol 272:E218-E226
-
(1997)
Am J Physiol
, vol.272
-
-
Schmitz, O.1
Porksen, N.2
Nyholm, B.3
-
123
-
-
0029816099
-
Failure to adequately adapt reduced insulin sensitivity with increased insulin secretion in women with impaired glucose tolerance
-
Larsson H, Ahren B (1996) Failure to adequately adapt reduced insulin sensitivity with increased insulin secretion in women with impaired glucose tolerance. Diabetologia 39:1099-1107
-
(1996)
Diabetologia
, vol.39
, pp. 1099-1107
-
-
Larsson, H.1
Ahren, B.2
-
124
-
-
0027296318
-
Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus
-
O'Meara NM, Sturis J, Van Cauter E, Polonsky KS (1993) Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus. J Clin Invest 92:262-271
-
(1993)
J Clin Invest
, vol.92
, pp. 262-271
-
-
O'Meara, N.M.1
Sturis, J.2
Van Cauter, E.3
Polonsky, K.S.4
-
125
-
-
0028204065
-
Understanding oral glucose tolerance: Comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion
-
Phillips DI, Clark PM, Hales CN, Osmond C (1994) Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med 11:286-292
-
(1994)
Diabet Med
, vol.11
, pp. 286-292
-
-
Phillips, D.I.1
Clark, P.M.2
Hales, C.N.3
Osmond, C.4
-
126
-
-
0027967674
-
Impaired post-prandial glucose utilization in non-insulin-dependent diabetes mellitus
-
Kelley D, Mokan M, Veneman T (1994) Impaired post-prandial glucose utilization in non-insulin-dependent diabetes mellitus. Metabolism 43:1549-1557
-
(1994)
Metabolism
, vol.43
, pp. 1549-1557
-
-
Kelley, D.1
Mokan, M.2
Veneman, T.3
-
127
-
-
1842334456
-
Report of the expert committee on the diagnosis and classification of diabetes mellitus
-
American Diabetes Association (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197
-
(1997)
Diabetes Care
, vol.20
, pp. 1183-1197
-
-
-
128
-
-
0025304242
-
Islet amyloid polypeptide in diabetic and non-diabetic Pima Indians
-
Clark A, Saad MF, Nezzer T et al. (1990) Islet amyloid polypeptide in diabetic and non-diabetic Pima Indians. Diabetologia 33:285-289
-
(1990)
Diabetologia
, vol.33
, pp. 285-289
-
-
Clark, A.1
Saad, M.F.2
Nezzer, T.3
-
129
-
-
0032969276
-
Islet amyloid: A long-recognized but underappreciated pathological feature of type 2 diabetes
-
Kahn SE, Andrikopoulos S, Verchere CB (1999) Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes. Diabetes 48:241-253
-
(1999)
Diabetes
, vol.48
, pp. 241-253
-
-
Kahn, S.E.1
Andrikopoulos, S.2
Verchere, C.B.3
-
130
-
-
0023192941
-
Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islets
-
Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islets. Proc Natl Acad Sci USA 84:3881-3885
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 3881-3885
-
-
Westermark, P.1
Wernstedt, C.2
Wilander, E.3
Hayden, D.W.4
O'Brien, T.D.5
Johnson, K.H.6
-
131
-
-
0023579739
-
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
-
Cooper GJS, Willis AC, Clark A, Turner RC, Sim RB, Reid KBM (1987) Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84:8628-8632
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 8628-8632
-
-
Cooper, G.J.S.1
Willis, A.C.2
Clark, A.3
Turner, R.C.4
Sim, R.B.5
Reid, K.B.M.6
-
132
-
-
0025366838
-
Islet amyloid polypeptide: Pinpointing amino acid residues linked to amyloid fibril formation
-
Westermark P, Engstrom U, Johnson KH, Westermark GT, Betsholtz C (1990) Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 87:5036-5040
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 5036-5040
-
-
Westermark, P.1
Engstrom, U.2
Johnson, K.H.3
Westermark, G.T.4
Betsholtz, C.5
-
133
-
-
0029978228
-
Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide
-
Verchere CB, D'Alessio DA, Palmiter RD et al. (1996) Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci USA 93:3492-3496
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3492-3496
-
-
Verchere, C.B.1
D'Alessio, D.A.2
Palmiter, R.D.3
-
134
-
-
0031920985
-
Islet amyloid-associated diabetes in obese Avy/a mice expressing human islet amyloid polypeptide
-
Soeller WC, Janson J, Hart SE et al. (1998) Islet amyloid-associated diabetes in obese Avy/a mice expressing human islet amyloid polypeptide. Diabetes 47:743-750
-
(1998)
Diabetes
, vol.47
, pp. 743-750
-
-
Soeller, W.C.1
Janson, J.2
Hart, S.E.3
-
135
-
-
0141780910
-
Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: Pathogenesis of diabetes in a mouse model
-
Höppener JW, Oosterwijk C, Nieuwenhuis MG et al. (1999) Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model. Diabetologia 42:427-434
-
(1999)
Diabetologia
, vol.42
, pp. 427-434
-
-
Höppener, J.W.1
Oosterwijk, C.2
Nieuwenhuis, M.G.3
-
136
-
-
0022496637
-
Longitudinal studies on the development of diabetes in individual Macaca nigra
-
Howard CF Jr (1986) Longitudinal studies on the development of diabetes in individual Macaca nigra. Diabetologia 29:301-306
-
(1986)
Diabetologia
, vol.29
, pp. 301-306
-
-
Howard C.F., Jr.1
-
137
-
-
0035514444
-
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells
-
Wang F, Hull RL, Vidal J, Cnop M, Kahn SE (2001) Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. Diabetes 50:2514-2520
-
(2001)
Diabetes
, vol.50
, pp. 2514-2520
-
-
Wang, F.1
Hull, R.L.2
Vidal, J.3
Cnop, M.4
Kahn, S.E.5
-
138
-
-
0026731869
-
Glucose toxicity
-
Yki-Järvinen H (1992) Glucose toxicity. Endocr Rev 13:415-431
-
(1992)
Endocr Rev
, vol.13
, pp. 415-431
-
-
Yki-Järvinen, H.1
-
139
-
-
0028000563
-
Differentiating glucose toxicity from glucose desensitization: A new message from the insulin gene
-
Robertson RP, Olson LK, Zhang HJ (1994) Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene. Diabetes 43:1085-1089
-
(1994)
Diabetes
, vol.43
, pp. 1085-1089
-
-
Robertson, R.P.1
Olson, L.K.2
Zhang, H.J.3
-
140
-
-
0021990787
-
The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus
-
Garvey WT, Olefsky JM, Griffen J, Hamman RF, Kolterman OG (1985) The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes 34:222-234
-
(1985)
Diabetes
, vol.34
, pp. 222-234
-
-
Garvey, W.T.1
Olefsky, J.M.2
Griffen, J.3
Hamman, R.F.4
Kolterman, O.G.5
-
141
-
-
0026751462
-
Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans
-
Kahn SE, Bergman RN, Schwartz MW, Taborsky GJ Jr, Porte D Jr (1992) Short-term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans. Am J Physiol 262:E518-E523
-
(1992)
Am J Physiol
, vol.262
-
-
Kahn, S.E.1
Bergman, R.N.2
Schwartz, M.W.3
Taborsky G.J., Jr.4
Porte D., Jr.5
-
142
-
-
0021433132
-
Adaptation of B and A cell function during prolonged glucose infusion in human subjects
-
Ward WK, Halter JB, Beard JC, Porte D Jr (1984) Adaptation of B and A cell function during prolonged glucose infusion in human subjects. Am J Physiol 246:E405-E411
-
(1984)
Am J Physiol
, vol.246
-
-
Ward, W.K.1
Halter, J.B.2
Beard, J.C.3
Porte D., Jr.4
-
143
-
-
0028833041
-
Insulin secretion and clearance during low-dose graded glucose infusion
-
Byrne MM, Sturis J, Polonsky KS (1995) Insulin secretion and clearance during low-dose graded glucose infusion. Am J Physiol 268:E21-E27
-
(1995)
Am J Physiol
, vol.268
-
-
Byrne, M.M.1
Sturis, J.2
Polonsky, K.S.3
-
144
-
-
0030030164
-
Proinsulin, C-peptide, and insulin in normal subjects during an 8-h hyperglycemic clamp
-
Hartling SG, Røder ME, Dinesen B, Binder C (1996) Proinsulin, C-peptide, and insulin in normal subjects during an 8-h hyperglycemic clamp. Eur J Endocrinol 134:197-200
-
(1996)
Eur J Endocrinol
, vol.134
, pp. 197-200
-
-
Hartling, S.G.1
Røder, M.E.2
Dinesen, B.3
Binder, C.4
-
145
-
-
0024244339
-
Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
-
Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD (1988) Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37:1020-1024
-
(1988)
Diabetes
, vol.37
, pp. 1020-1024
-
-
Reaven, G.M.1
Hollenbeck, C.2
Jeng, C.Y.3
Wu, M.S.4
Chen, Y.D.5
-
147
-
-
0028268936
-
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
-
Zhou YP, Grill VE (1994) Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876
-
(1994)
J Clin Invest
, vol.93
, pp. 870-876
-
-
Zhou, Y.P.1
Grill, V.E.2
-
148
-
-
0029036835
-
Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
-
Zhou YP, Grill V (1995) Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80:1584-1590
-
(1995)
J Clin Endocrinol Metab
, vol.80
, pp. 1584-1590
-
-
Zhou, Y.P.1
Grill, V.2
-
149
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
-
Boden G (1997) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10
-
(1997)
Diabetes
, vol.46
, pp. 3-10
-
-
Boden, G.1
-
150
-
-
0029948212
-
Mechanism of free fatty acid-induced insulin resistance in humans
-
Roden M, Price TB, Perseghin G et al. (1996) Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97:2859-2865
-
(1996)
J Clin Invest
, vol.97
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
-
151
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
-
Griffin ME, Marcucci MJ, Cline GW et al. (1999) Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48:1270-1274
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
-
152
-
-
0029046673
-
Effects of a 48-h fat infusion on insulin secretion and glucose utilization
-
Boden G, Chen X, Rosner J, Barton M (1995) Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 44:1239-1242
-
(1995)
Diabetes
, vol.44
, pp. 1239-1242
-
-
Boden, G.1
Chen, X.2
Rosner, J.3
Barton, M.4
-
153
-
-
0032999260
-
Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation
-
Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF (1999) Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol 276:E1055-E1066
-
(1999)
Am J Physiol
, vol.276
-
-
Carpentier, A.1
Mittelman, S.D.2
Lamarche, B.3
Bergman, R.N.4
Giacca, A.5
Lewis, G.F.6
-
154
-
-
0028849148
-
Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects
-
Paolisso G, Gambardella A, Amato L et al. (1995) Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects. Diabetologia 38:1295-1299
-
(1995)
Diabetologia
, vol.38
, pp. 1295-1299
-
-
Paolisso, G.1
Gambardella, A.2
Amato, L.3
-
155
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661-671
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte D., Jr.3
Seeley, R.J.4
Baskin, D.G.5
-
156
-
-
15444339427
-
Obesity, diabetes and the central nervous system
-
Porte D Jr, Seeley RJ, Woods SC, Baskin DG, Figlewicz DP, Schwartz MW (1998) Obesity, diabetes and the central nervous system. Diabetologia 41:863-881
-
(1998)
Diabetologia
, vol.41
, pp. 863-881
-
-
Porte D., Jr.1
Seeley, R.J.2
Woods, S.C.3
Baskin, D.G.4
Figlewicz, D.P.5
Schwartz, M.W.6
-
157
-
-
0025750835
-
Prevention of Type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise: The 6-year Malmo: Feasibility study
-
Eriksson K-F, Lindgarde F (1991) Prevention of Type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise: the 6-year Malmo: feasibility study. Diabetologia 34:891-898
-
(1991)
Diabetologia
, vol.34
, pp. 891-898
-
-
Eriksson, K.-F.1
Lindgarde, F.2
-
158
-
-
0030935652
-
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes study
-
Pan XR, Li GW, Hu YH et al. (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20:537-544
-
(1997)
Diabetes Care
, vol.20
, pp. 537-544
-
-
Pan, X.R.1
Li, G.W.2
Hu, Y.H.3
-
159
-
-
0035799806
-
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
-
Tuomilehto J, Lindstrom J, Eriksson JG et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350
-
(2001)
N Engl J Med
, vol.344
, pp. 1343-1350
-
-
Tuomilehto, J.1
Lindstrom, J.2
Eriksson, J.G.3
-
160
-
-
0037097039
-
Acarbose for prevention of type 2 diabetes mellitus: The STOP-NIDDM randomised trial
-
Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M (2002) Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 359:2072-2077
-
(2002)
Lancet
, vol.359
, pp. 2072-2077
-
-
Chiasson, J.L.1
Josse, R.G.2
Gomis, R.3
Hanefeld, M.4
Karasik, A.5
Laakso, M.6
-
161
-
-
0036724346
-
Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high- risk hispanic women
-
Buchanan TA, Xiang AH, Peters RK et al. (2002) Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high- risk hispanic women. Diabetes 51:2796-2803
-
(2002)
Diabetes
, vol.51
, pp. 2796-2803
-
-
Buchanan, T.A.1
Xiang, A.H.2
Peters, R.K.3
-
162
-
-
0033030445
-
Design and methods for a clinical trial in the prevention of type 2 diabetes
-
The Diabetes Prevention Program
-
The Diabetes Prevention Program Research Group (1999) The Diabetes Prevention Program. Design and methods for a clinical trial in the prevention of type 2 diabetes. Diabetes Care 22:623-634
-
(1999)
Diabetes Care
, vol.22
, pp. 623-634
-
-
-
163
-
-
0035904369
-
Ramipril and the development of diabetes
-
Yusuf S, Gerstein H, Hoogwerf B et al. (2001) Ramipril and the development of diabetes. JAMA 286:1882-1885
-
(2001)
JAMA
, vol.286
, pp. 1882-1885
-
-
Yusuf, S.1
Gerstein, H.2
Hoogwerf, B.3
-
164
-
-
0000783268
-
Targeting post-prandial hyperglycemia to prevent type 2 diabetes: Rationale and design of the NAVIGATOR trial
-
Abstract
-
Haffner S, Holman R, Califf R, McMurray J, Pehcer E (2002) Targeting post-prandial hyperglycemia to prevent type 2 diabetes: Rationale and design of the NAVIGATOR trial. Diabetologia 45 [Suppl 2]:A106 (Abstract)
-
(2002)
Diabetologia
, vol.45
, Issue.SUPPL. 2
-
-
Haffner, S.1
Holman, R.2
Califf, R.3
McMurray, J.4
Pehcer, E.5
-
165
-
-
0035936527
-
Pravastatin and the development of diabetes mellitus: Evidence for a protective treatment effect in the West of Scotland Coronary Prevention study
-
Freeman DJ, Norrie J, Sattar N et al. (2001) Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation 103:357-362
-
(2001)
Circulation
, vol.103
, pp. 357-362
-
-
Freeman, D.J.1
Norrie, J.2
Sattar, N.3
-
166
-
-
0025605915
-
Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects
-
Welch S, Gebhart SSP, Bergman RN, Phillips LS (1990) Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab 71:1508-1518
-
(1990)
J Clin Endocrinol Metab
, vol.71
, pp. 1508-1518
-
-
Welch, S.1
Gebhart, S.S.P.2
Bergman, R.N.3
Phillips, L.S.4
-
167
-
-
0002430134
-
Regulation of insulin secretion in vivo
-
Lowe WL Jr (ed.). Kluwer, Stamford
-
Vidal J, Kahn SE (2001) Regulation of insulin secretion in vivo. In: Lowe WL Jr (ed.) Genetics of Diabetes Mellitus. Kluwer, Stamford, pp 109-131
-
(2001)
Genetics of Diabetes Mellitus
, pp. 109-131
-
-
Vidal, J.1
Kahn, S.E.2
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