Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model

Molecular Medicine Reports

Volumn 2, Issue 6, 2009, Pages 897-902

  Maeda, Hayato ^a   Hosokawa, Masashi ^b   Sashima, Tokutake ^b   Murakami Funayama, Katsura ^c   Miyashita, Kazuo ^b  

^a HIROSAKI UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c RIKEN VITAMIN CO LTD   (Japan)

Author keywords

Anti obesity; Fucoxanthin; Glucose transporter 4; Monocyte chemoattractant protein 1; Wakame lipids; 3 adrenergic receptor

Indexed keywords

ANTIDIABETIC AGENT; ANTIOBESITY AGENT; BETA ADRENERGIC RECEPTOR; FUCOXANTHIN; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; LEPTIN; LIPID; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERLEPTINEMIA; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; LIPID DIET; MALE; MOUSE; MUSCLE TISSUE; NONHUMAN; OBESITY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SKELETAL MUSCLE; UNDARIA; WEIGHT GAIN; WHITE ADIPOSE TISSUE;

MURINAE; MUS; PHAEOPHYCEAE; UNDARIA PINNATIFIDA;

EID: 73649136846     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr_00000189     Document Type: Article

References (24)

1. Lew EA and Garfinkel L: Variations in mortality by weight among 750,000 men and women. J Chronic Dis 32: 563-576, 1979.
2. Olefsky JM, Revers RR, Prince M, Henry RR, Garvey WT, Scarlett JA and Kolterman OG: Insulin resistance in non-insulin dependent (type II) and insulin dependent (type I) diabetes mellitus. Adv Exp Med Biol 189: 176-205, 1985.
3. Buettner R, Schölmerich J and Bollheimer LC: High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity 15: 798-808, 2007.
4. Maeda H, Hosokawa M, Sashima T, Funayama K and Miyashita K: Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 332: 392-397, 2005.
5. y mice. J Agric Food Chem 55: 7701-7706, 2007.
6. Hotamisligil GS, Shargill NS and Spiegelman BM: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
7. Matsuzawa Y, Shimomura I, Kihara S and Funahashi T: Importance of adipocytokines in obesity-related diseases. Horm Res 60: 56-59, 2003.
8. Shoelson SE, Lee J and Goldfine AB: Inflammation and insulin resistance. J Clin Invest 116: 1793-17801, 2006.
9. Hotamisligil GS, Arner P, Caro JF, Atkinson RL and Spiegelman BM: Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95: 2409-2415, 1995.
10. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI and Kahn BB: Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409: 672-673, 2001.
11. Wellen KE and Hotamisligil GS: Inflammation, stress, and diabetes. J Clin Invest 115: 1111-1119, 2005.
12. Kahn BB and Pedersen O: Suppression of GLUT4 expression in skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity. Endocrinology 132: 13-22, 1993.
13. Kim Y, Tamura T, Iwashita S, Tokuyama K and Suzuki M: Effect of high-fat diet on gene expression of GLUT4 and insulin receptor in soleus muscle. Biochem Biophys Res Commun 202: 519-526, 1994.
14. Charron MJ, Katz EB and Olson AL: GLUT4 gene regulation and manipulation. J Biol Chem 274: 3253-3256, 1999.
15. Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T and Miyashita K: Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med 18: 147-152, 2006.
16. Kotake-Nara E, Kushiro M, Zhang H, Sugawara T, Miyashita K and Nagao A: Carotenoids affect proliferation of human prostate cancer cells. J Nutr 131: 3303-3306, 2001.
17. Murata M, Sano Y, Ishihara K and Uchida M: Dietary fish oil and Undaria pinnatifida (wakame) synergistically decrease rat serum and liver triacylglycerol. J Nutr 132: 742-747, 1985.
18. Armoni M, Harel C and Karnieli E: Transcriptional regulation of the GLUT4 gene: from PPAR-gamma and FOXO1 to FFA and inflammation. Trends Endocrinol Metab 18: 100-107, 2007.
19. Olefsky JM and Saltiel AR: PPAR gamma and the treatment of insulin resistance. Trends Endocrinol Metab 11: 362-368, 2000.
20. Matsuzawa Y: The metabolic syndrome and adipocytokines. FEBS Lett 580: 2917-2921, 2006.
21. Watson PM, Commins SP, Beiler RJ, Hatcher HC and Gettys TW: Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity. Am J Physiol Endocrinol Metab 279: E356-E365, 2000.
22. Krief S, Lönnqvist F, Raimbault S, Baude B, van Spronsen A, Arner P, Strosberg AD, Ricquier D and Emorine LJ: Tissue distribution of beta 3-adrenergic receptor mRNA in man. J Clin Invest 91: 344-349, 1993.
23. Lönnqvist F, Thöme A, Nilsell K, Hoffstedt J and Arner P: A pathogenic role of visceral fat beta 3-adrenoceptors in obesity. J Clin Invest 95: 1109-1116, 1995.
24. Collins S, Daniel KW and Rohlfs EM: Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. Int J Obes Relat Metab Disord 23: 669-677, 1999.