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Volumn 18, Issue 2, 2005, Pages 212-221

Therapeutic potential of curcumin in non-alcoholic steatohepatitis

Author keywords

Curcumin; Diferuloylmethane; Fibrosis; Oxidative stress; Steatohepatitis; Steatosis

Indexed keywords

CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYPHENOL;

EID: 31144478126     PISSN: 09544224     EISSN: None     Source Type: Journal    
DOI: 10.1079/NRR2005106     Document Type: Review
Times cited : (28)

References (97)
  • 1
    • 0032991568 scopus 로고    scopus 로고
    • Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages
    • Abe Y, Hashimoto S & Horie T (1999) Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacological Research 39, 41-47.
    • (1999) Pharmacological Research , vol.39 , pp. 41-47
    • Abe, Y.1    Hashimoto, S.2    Horie, T.3
  • 2
    • 0037236792 scopus 로고    scopus 로고
    • Anticancer potential of curcumin: Preclinical and clinical studies
    • Aggarwal BB, Kumar A & Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Research 23, 363-398.
    • (2003) Anticancer Research , vol.23 , pp. 363-398
    • Aggarwal, B.B.1    Kumar, A.2    Bharti, A.C.3
  • 4
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P (2002) Nonalcoholic fatty liver disease. New England Journal of Medicine 346, 1221-1231.
    • (2002) New England Journal of Medicine , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 5
    • 0035171859 scopus 로고    scopus 로고
    • Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue
    • Asai A & Miyazawa T (2001) Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. Journal of Nutrition 131, 2932-2935.
    • (2001) Journal of Nutrition , vol.131 , pp. 2932-2935
    • Asai, A.1    Miyazawa, T.2
  • 6
    • 8044223405 scopus 로고    scopus 로고
    • Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats
    • Babu PS & Srinivasan K (1997) Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Molecular and Cellular Biochemistry 166, 169-175.
    • (1997) Molecular and Cellular Biochemistry , vol.166 , pp. 169-175
    • Babu, P.S.1    Srinivasan, K.2
  • 10
  • 11
    • 0029047933 scopus 로고
    • Inhibition of tumor necrosis factor by curcumin, a phytochemical
    • Chan MM (1995) Inhibition of tumor necrosis factor by curcumin, a phytochemical. Biochemical Pharmacology 49, 1551-1556.
    • (1995) Biochemical Pharmacology , vol.49 , pp. 1551-1556
    • Chan, M.M.1
  • 13
    • 13844306722 scopus 로고    scopus 로고
    • Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates the suppression of the gene expression of cyclin D1 and EGFR
    • Chen A & Xu J (2005) Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates the suppression of the gene expression of cyclin D1 and EGFR. American Journal of Physiology 288, G447-G456.
    • (2005) American Journal of Physiology , vol.288
    • Chen, A.1    Xu, J.2
  • 14
    • 0032537814 scopus 로고    scopus 로고
    • Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin
    • Chen YR & Tan TH (1998) Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene 17, 173-178.
    • (1998) Oncogene , vol.17 , pp. 173-178
    • Chen, Y.R.1    Tan, T.H.2
  • 16
    • 4344628553 scopus 로고    scopus 로고
    • Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease
    • Choudhury J & Sanyal AJ (2004) Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease. Clinics in Liver Disease 8, 575-594.
    • (2004) Clinics in Liver Disease , vol.8 , pp. 575-594
    • Choudhury, J.1    Sanyal, A.J.2
  • 17
    • 0033801316 scopus 로고    scopus 로고
    • Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats
    • Chuang SE, Cheng AL, Lin JK & Kuo ML (2000a) Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food and Chemical Toxicology 38, 991-995.
    • (2000) Food and Chemical Toxicology , vol.38 , pp. 991-995
    • Chuang, S.E.1    Cheng, A.L.2    Lin, J.K.3    Kuo, M.L.4
  • 19
    • 0141814600 scopus 로고    scopus 로고
    • Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation
    • Chun KS, Keum YS, Han SS, Song YS, Kim SH & Surh YJ (2003) Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis 24, 1515-1524.
    • (2003) Carcinogenesis , vol.24 , pp. 1515-1524
    • Chun, K.S.1    Keum, Y.S.2    Han, S.S.3    Song, Y.S.4    Kim, S.H.5    Surh, Y.J.6
  • 21
    • 4344666158 scopus 로고    scopus 로고
    • Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease
    • Diehl AM (2004) Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease. Clinics in Liver Disease 8, 619-638.
    • (2004) Clinics in Liver Disease , vol.8 , pp. 619-638
    • Diehl, A.M.1
  • 22
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. Journal of Biological Chemistry 275, 2247-2250.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 23
    • 3042766204 scopus 로고    scopus 로고
    • Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells
    • Gaedeke J, Noble NA & Border WA (2004) Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells. Kidney International 66, 112-120.
    • (2004) Kidney International , vol.66 , pp. 112-120
    • Gaedeke, J.1    Noble, N.A.2    Border, W.A.3
  • 24
    • 2942624044 scopus 로고    scopus 로고
    • Immunomodulatory activity of curcumin: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro
    • Gao X, Kuo J, Jiang H, Deeb D, Liu Y, Divine G, Chapman RA, Dulchavsky SA & Gautam SC (2004) Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro. Biochemical Pharmacology 68, 51-61.
    • (2004) Biochemical Pharmacology , vol.68 , pp. 51-61
    • Gao, X.1    Kuo, J.2    Jiang, H.3    Deeb, D.4    Liu, Y.5    Divine, G.6    Chapman, R.A.7    Dulchavsky, S.A.8    Gautam, S.C.9
  • 27
    • 0642375808 scopus 로고    scopus 로고
    • Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease
    • Heyninck K, Wullaert A & Beyaert R (2003) Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease. Biochemical Pharmacology 66, 1409-1415.
    • (2003) Biochemical Pharmacology , vol.66 , pp. 1409-1415
    • Heyninck, K.1    Wullaert, A.2    Beyaert, R.3
  • 28
    • 0345074085 scopus 로고    scopus 로고
    • Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: Possible role in protection against chemical carcinogenesis and toxicity
    • Iqbal M, Sharma SD, Okazaki Y, Fujisawa M & Okada S (2003) Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacology and Toxicology 92, 33-38.
    • (2003) Pharmacology and Toxicology , vol.92 , pp. 33-38
    • Iqbal, M.1    Sharma, S.D.2    Okazaki, Y.3    Fujisawa, M.4    Okada, S.5
  • 30
    • 0028134769 scopus 로고
    • Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages
    • Joe B & Lokesh BR (1994) Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochimica et Biophysica Acta 1224, 255-263.
    • (1994) Biochimica et Biophysica Acta , vol.1224 , pp. 255-263
    • Joe, B.1    Lokesh, B.R.2
  • 33
    • 7444250712 scopus 로고    scopus 로고
    • Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats
    • Kempaiah RK & Srinivasan K (2004) Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats. Annals of Nutrition Metabolism 48, 314-320.
    • (2004) Annals of Nutrition Metabolism , vol.48 , pp. 314-320
    • Kempaiah, R.K.1    Srinivasan, K.2
  • 34
    • 0032520716 scopus 로고    scopus 로고
    • Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappa B activation
    • Kumar A, Dhawan S, Hardegen NJ & Aggarwal BB (1998) Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappa B activation. Biochemical Pharmacology 55, 775-783.
    • (1998) Biochemical Pharmacology , vol.55 , pp. 775-783
    • Kumar, A.1    Dhawan, S.2    Hardegen, N.J.3    Aggarwal, B.B.4
  • 35
    • 9644295733 scopus 로고    scopus 로고
    • Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice
    • Leclercq IA, Farrell GC, Sempoux C, Pena AD & Horsmans Y (2004) Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. Journal of Hepatology 41, 926-934.
    • (2004) Journal of Hepatology , vol.41 , pp. 926-934
    • Leclercq, I.A.1    Farrell, G.C.2    Sempoux, C.3    Pena, A.D.4    Horsmans, Y.5
  • 39
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim GP, Chu T, Yang F, Beech W, Frautschy SA & Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. Journal of Neuroscience 21, 8370-8377.
    • (2001) Journal of Neuroscience , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 40
    • 0036579629 scopus 로고    scopus 로고
    • Effect of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin
    • Lukita-Atmadja W, Ito Y, Baker GL & McCuskey RS (2002) Effect of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin. Shock 17, 399-403.
    • (2002) Shock , vol.17 , pp. 399-403
    • Lukita-Atmadja, W.1    Ito, Y.2    Baker, G.L.3    McCuskey, R.S.4
  • 41
    • 0038819892 scopus 로고    scopus 로고
    • Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock
    • Madan B & Ghosh B (2003) Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock. Shock 19, 91-96.
    • (2003) Shock , vol.19 , pp. 91-96
    • Madan, B.1    Ghosh, B.2
  • 45
    • 1842431048 scopus 로고    scopus 로고
    • Reactions of superoxide radicals with curcumin: Probable mechanisms by optical spectroscopy and EPR
    • Mishra B, Priyadarsini KI, Bhide MK, Kadam RM & Mohan H (2004) Reactions of superoxide radicals with curcumin: probable mechanisms by optical spectroscopy and EPR. Free Radical Research 38, 355-362.
    • (2004) Free Radical Research , vol.38 , pp. 355-362
    • Mishra, B.1    Priyadarsini, K.I.2    Bhide, M.K.3    Kadam, R.M.4    Mohan, H.5
  • 46
    • 0036583502 scopus 로고    scopus 로고
    • Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha
    • Morikawa T, Matsuda H, Ninomiya K & Yoshikawa M (2002) Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha. Biological and Pharmaceutical Bulletin 25, 627-631.
    • (2002) Biological and Pharmaceutical Bulletin , vol.25 , pp. 627-631
    • Morikawa, T.1    Matsuda, H.2    Ninomiya, K.3    Yoshikawa, M.4
  • 47
    • 0034655773 scopus 로고    scopus 로고
    • Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
    • Motterlini R, Foresti R, Bassi R & Green CJ (2000) Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radical Biology and Medicine 28, 1303-1312.
    • (2000) Free Radical Biology and Medicine , vol.28 , pp. 1303-1312
    • Motterlini, R.1    Foresti, R.2    Bassi, R.3    Green, C.J.4
  • 52
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • Neuschwander-Tetri BA & Caldwell SH (2003) Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 37, 1202-1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 55
  • 57
    • 15944429716 scopus 로고    scopus 로고
    • Zedoariae rhizoma and curcumin inhibits platelet-derived growth factor-induced proliferation of human hepatic myofibroblasts
    • Park SD, Jung JH, Lee HW, Kwon YM, Chung KH, Kim MG & Kim CH (2005) Zedoariae rhizoma and curcumin inhibits platelet-derived growth factor-induced proliferation of human hepatic myofibroblasts. International Immunophamacology 5, 555-569.
    • (2005) International Immunophamacology , vol.5 , pp. 555-569
    • Park, S.D.1    Jung, J.H.2    Lee, H.W.3    Kwon, Y.M.4    Chung, K.H.5    Kim, M.G.6    Kim, C.H.7
  • 58
    • 0031457663 scopus 로고    scopus 로고
    • Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin. Suppression of activation of transcription factors Egr-1, AP-1, and NF-kappa B
    • Pendurthi UR, Williams JT & Rao LV (1997) Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin. Suppression of activation of transcription factors Egr-1, AP-1, and NF-kappa B. Arteriosclerosis, Thrombosis and Vascular Biology 17, 3406-3413.
    • (1997) Arteriosclerosis, Thrombosis and Vascular Biology , vol.17 , pp. 3406-3413
    • Pendurthi, U.R.1    Williams, J.T.2    Rao, L.V.3
  • 59
    • 0038191064 scopus 로고    scopus 로고
    • Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways
    • Philip S & Kundu GC (2003) Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. Journal of Biological Chemistry 278, 14487-14497.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 14487-14497
    • Philip, S.1    Kundu, G.C.2
  • 60
    • 0033613436 scopus 로고    scopus 로고
    • Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex
    • Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S & Howells L (1999) Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 18, 6013-6020.
    • (1999) Oncogene , vol.18 , pp. 6013-6020
    • Plummer, S.M.1    Holloway, K.A.2    Manson, M.M.3    Munks, R.J.4    Kaptein, A.5    Farrow, S.6    Howells, L.7
  • 61
    • 0041886512 scopus 로고    scopus 로고
    • Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats
    • Punithavathi D, Venkatesan N & Babu M (2003) Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. British Journal of Pharmacology 139, 1342-1450.
    • (2003) British Journal of Pharmacology , vol.139 , pp. 1342-1450
    • Punithavathi, D.1    Venkatesan, N.2    Babu, M.3
  • 62
    • 0031875872 scopus 로고    scopus 로고
    • An ethanolic-aqueous extract of Curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits
    • Quiles JL, Aguilera C, Mesa MD, Ramirez-Tortosa MC, Baro L & Gil A (1998) An ethanolic-aqueous extract of Curcuma longa decreases the susceptibility of liver microsomes and mitochondria to lipid peroxidation in atherosclerotic rabbits. Biofactors 8, 51-57.
    • (1998) Biofactors , vol.8 , pp. 51-57
    • Quiles, J.L.1    Aguilera, C.2    Mesa, M.D.3    Ramirez-Tortosa, M.C.4    Baro, L.5    Gil, A.6
  • 64
    • 0032990654 scopus 로고    scopus 로고
    • The effect of curcumin and placebo on human gall-bladder function: An ultrasound study
    • Rasyid A & Lelo A (1999) The effect of curcumin and placebo on human gall-bladder function: an ultrasound study. Alimentary Pharmacology and Therapeutics 13, 245-249.
    • (1999) Alimentary Pharmacology and Therapeutics , vol.13 , pp. 245-249
    • Rasyid, A.1    Lelo, A.2
  • 66
    • 0028278766 scopus 로고
    • Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver
    • Reddy AC & Lokesh BR (1994) Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food and Chemical Toxicology 32, 279-283.
    • (1994) Food and Chemical Toxicology , vol.32 , pp. 279-283
    • Reddy, A.C.1    Lokesh, B.R.2
  • 67
    • 0343618374 scopus 로고    scopus 로고
    • Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats
    • Reddy AC & Lokesh BR (1996) Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology 107, 39-45.
    • (1996) Toxicology , vol.107 , pp. 39-45
    • Reddy, A.C.1    Lokesh, B.R.2
  • 68
    • 0346689994 scopus 로고    scopus 로고
    • The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
    • Rinella ME & Green RM (2004) The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. Journal of Hepatology 40, 47-51.
    • (2004) Journal of Hepatology , vol.40 , pp. 47-51
    • Rinella, M.E.1    Green, R.M.2
  • 70
    • 15844384868 scopus 로고    scopus 로고
    • Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity
    • Rukkumani R, Aruna K, Varma PS & Menon VP (2004a) Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity. Italian Journal of Biochemistry 43, 61-66.
    • (2004) Italian Journal of Biochemistry , vol.43 , pp. 61-66
    • Rukkumani, R.1    Aruna, K.2    Varma, P.S.3    Menon, V.P.4
  • 72
    • 0141737859 scopus 로고    scopus 로고
    • Protective effects of curcumin and photo-irradiated curcumin on circulatory lipids and lipid peroxidation products in alcohol and polyunsaturated fatty acid-induced toxicity
    • Rukkumani R, Sri Balasubashini M & Menon VP (2003) Protective effects of curcumin and photo-irradiated curcumin on circulatory lipids and lipid peroxidation products in alcohol and polyunsaturated fatty acid-induced toxicity. Phytotherapy Research 17, 925-929.
    • (2003) Phytotherapy Research , vol.17 , pp. 925-929
    • Rukkumani, R.1    Sri Balasubashini, M.2    Menon, V.P.3
  • 73
    • 0036425263 scopus 로고    scopus 로고
    • Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia
    • Rukkumani R, Sri Balasubashini M, Vishwanathan P & Menon VP (2002) Comparative effects of curcumin and photo-irradiated curcumin on alcohol- and polyunsaturated fatty acid-induced hyperlipidemia. Pharmacogical Research 46, 257-264.
    • (2002) Pharmacogical Research , vol.46 , pp. 257-264
    • Rukkumani, R.1    Sri Balasubashini, M.2    Vishwanathan, P.3    Menon, V.P.4
  • 74
    • 3042550624 scopus 로고    scopus 로고
    • Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model
    • Sahai A, Malladi P, Melin-Aldana H, Green RM & Whitington PF (2004) Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. American Journal of Physiology 287, G264-G273.
    • (2004) American Journal of Physiology , vol.287
    • Sahai, A.1    Malladi, P.2    Melin-Aldana, H.3    Green, R.M.4    Whitington, P.F.5
  • 76
    • 7044269614 scopus 로고    scopus 로고
    • Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis
    • Satapathy SK, Garg S, Chauhan R, Sakhuja P, Malhotra V, Sharma BC & Sarin SK (2004) Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis. American Journal of Gastroenterology 99, 1946-1952.
    • (2004) American Journal of Gastroenterology , vol.99 , pp. 1946-1952
    • Satapathy, S.K.1    Garg, S.2    Chauhan, R.3    Sakhuja, P.4    Malhotra, V.5    Sharma, B.C.6    Sarin, S.K.7
  • 81
    • 0042168966 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: Correlation with suppression of COX-2, MMP-9 and cyclin D1
    • Shishodia S, Potdar P, Gairola CG & Aggarwal BB (2003) Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 24, 1269-1279.
    • (2003) Carcinogenesis , vol.24 , pp. 1269-1279
    • Shishodia, S.1    Potdar, P.2    Gairola, C.G.3    Aggarwal, B.B.4
  • 82
    • 0032558167 scopus 로고    scopus 로고
    • Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: A new class of renoprotective agents
    • Shoskes DA (1998) Effect of bioflavonoids quercetin and curcumin on ischemic renal injury: a new class of renoprotective agents. Transplantation 66, 147-152.
    • (1998) Transplantation , vol.66 , pp. 147-152
    • Shoskes, D.A.1
  • 83
    • 0038647594 scopus 로고    scopus 로고
    • Suppression of altered hepatic foci development by curcumin in Wistar rats
    • Shukla Y & Arora A (2003) Suppression of altered hepatic foci development by curcumin in Wistar rats. Nutrition and Cancer 45, 53-59.
    • (2003) Nutrition and Cancer , vol.45 , pp. 53-59
    • Shukla, Y.1    Arora, A.2
  • 84
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane)
    • Singh S & Aggarwal BB (1995) Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane). Journal of Biological Chemistry 270, 24995-25000.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 86
    • 4644364745 scopus 로고    scopus 로고
    • Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2
    • Syng-Ai C, Kumari AL & Khar A (2004) Effect of curcumin on normal and tumor cells: role of glutathione and bcl-2. Molecular Cancer Therapeutics 3, 1101-1108.
    • (2004) Molecular Cancer Therapeutics , vol.3 , pp. 1101-1108
    • Syng-Ai, C.1    Kumari, A.L.2    Khar, A.3
  • 87
    • 0031801988 scopus 로고    scopus 로고
    • Curcumin attenuation of acute adriamycin myocardial toxicity in rats
    • Venkatesan N (1998) Curcumin attenuation of acute adriamycin myocardial toxicity in rats. British Journal of Pharmacology 124, 425-427.
    • (1998) British Journal of Pharmacology , vol.124 , pp. 425-427
    • Venkatesan, N.1
  • 89
    • 0033807753 scopus 로고    scopus 로고
    • Structure-activity relationships for the inhibition of lipid peroxidation and the scavenging of free radicals by synthetic symmetrical curcumin analogues
    • Venkatesan P & Rao MN (2000) Structure-activity relationships for the inhibition of lipid peroxidation and the scavenging of free radicals by synthetic symmetrical curcumin analogues. Journal of Pharmacy and Pharmacology 52, 1123-1128.
    • (2000) Journal of Pharmacy and Pharmacology , vol.52 , pp. 1123-1128
    • Venkatesan, P.1    Rao, M.N.2
  • 92
    • 0037663778 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth
    • Xu J, Fu Y & Chen A (2003) Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. American Journal of Physiology 285, G20-G30.
    • (2003) American Journal of Physiology , vol.285
    • Xu, J.1    Fu, Y.2    Chen, A.3
  • 94
    • 16544362781 scopus 로고    scopus 로고
    • Curcumin ameliorates left ventricular function in rabbits with pressure overload: Inhibition of the remodeling of the left ventricular collagen network associated with suppression of myocardial tumor necrosis factor-alpha and matrix metalloproteinase-2 expression
    • Yao QH, Wang DQ, Cui CC, Yuan ZY, Chen SB, Yao XW, Wang JK & Lian JF (2004) Curcumin ameliorates left ventricular function in rabbits with pressure overload: inhibition of the remodeling of the left ventricular collagen network associated with suppression of myocardial tumor necrosis factor-alpha and matrix metalloproteinase-2 expression. Biological and Pharmaceutical Bulletin 27, 198-202.
    • (2004) Biological and Pharmaceutical Bulletin , vol.27 , pp. 198-202
    • Yao, Q.H.1    Wang, D.Q.2    Cui, C.C.3    Yuan, Z.Y.4    Chen, S.B.5    Yao, X.W.6    Wang, J.K.7    Lian, J.F.8
  • 96
    • 9444252295 scopus 로고    scopus 로고
    • Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro
    • Zheng S & Chen A (2004) Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro. Biochemical Journal 384, 49-57.
    • (2004) Biochemical Journal , vol.384 , pp. 49-57
    • Zheng, S.1    Chen, A.2
  • 97
    • 0037382135 scopus 로고    scopus 로고
    • Heme oxygenase-1: A cellular Hercules
    • Zuckerbraun BS & Billiar TR (2003) Heme oxygenase-1: a cellular Hercules. Hepatology 37, 742-743.
    • (2003) Hepatology , vol.37 , pp. 742-743
    • Zuckerbraun, B.S.1    Billiar, T.R.2


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