Effects of docosahexaenoic acid in an experimental rat model of nonalcoholic steatohepatitis

Journal of Oleo Science

Volumn 59, Issue 8, 2010, Pages 407-414

  Takayama, Fusako ^a   Nakamoto, Kazuo ^a   Totani, Nagao ^b   Yamanushi, Tomoko ^d   Kabuto, Hideaki ^d   Kaneyuki, Takao ^c   Mankura, Mitsumasa ^a,e  

^a OKAYAMA UNIVERSITY   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

^c Kurashiki Sakuyo University   (Japan)

^d KAGAWA PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^e Ikeda Tohka Industries Company Limited   (Japan)

Author keywords

Dha; Docosahexaenoic acid; Functional foods; Hepatoprotection; Liver fibrosis; N 6 n 3 ratio; Nonalcoholic steatohepatitis; Oxidative stress

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DOCOSAHEXAENOIC ACID; LIPID PEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL; ARTICLE; BLOOD; DIET; DISEASE COURSE; DISEASE MODEL; DRUG EFFECT; DRUG SCREENING; FAT INTAKE; FATTY LIVER; LIPID METABOLISM; LIPID PEROXIDATION; LIVER; MALE; METABOLISM; PATHOLOGY; RAT; VITAMIN DEFICIENCY; WISTAR RAT;

ANIMALS; CHOLINE DEFICIENCY; DIET; DIETARY FATS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOCOSAHEXAENOIC ACIDS; DRUG EVALUATION, PRECLINICAL; FATTY LIVER; LIPID METABOLISM; LIPID PEROXIDATION; LIPID PEROXIDES; LIVER; MALE; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 77954353061     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.59.407     Document Type: Article

References (27)

1. Day, C. P.; James, O.F. Steatohepatitis: A tale of two hits? Gastroenterology 114, 842-845 (1998).
2. Takayama, F.; Egashira, T.; Kawasaki, H.; Mankura, M.; Nakamoto, K.; Okada, S.; Mori, A. A novel animal model of nonalcoholic steatohepatitis (NASH): Hypoxemia enhances the development of NASH. J. Clin. Biochem. Nutr. 45, 335-340 (2009).
3. Nakamoto, K.; Takayama, F.; Mankura, M.; Hidaka, Y.; Egashira, T.; Ogino, T.; Kawasaki, H.; Mori, A. Beneficial effects of fermented green tea extract in a rat model of non-alcoholic steatohepatitis. J. Clin. Biochem. Nutr. 44, 239-246 (2009).
4. Takayama, F.; Nakamoto, K.; Kawasaki, H.; Mankura, M.; Egashira, T.; Ueki, K.; Hasegawa, A.; Okada, S.; Mori, A. Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model. Acta Med. Okayama 63, 105-11 (2009).
5. Videla, L. A.; Rodrigo, R.; Araya, J.; Poniachik, J. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. Free Radic. Biol. Med. 37, 1499-1507 (2004).
6. Araya, J.; Rodrigo, R. Videla, L. A.; Thielemann, L.; Orellana, M.; Pettinelli, P.; Poniachik, J. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin. Sci. (Lond) 106, 635-643 (2004).
7. Mensink, R. P; Plat, J; Schrauwen, P. Diet and nonalcoholic fatty liver disease. Curr. Opin. Lipidol. 19, 25-29 (2008).
8. Allard, J. P; Aghdassi, E; Mohammed, S; Raman, M; Avand, G; Arendt, B. M; Jalali, P; Kandasamy, T; Prayitno, N; Sherman, M; Guindi, M; Ma, D. W; Heathcote, J. E. Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study. J. Hepatol. 48, 300-307 (2008).
9. Horrocks, L. A.; Yeo, Y. K. Health benefits of docosahexaenoic acid (DHA). Pharmacol. Res. 40, 211-225 (1999).
10. Clarke, S. D. Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription. Am. J. Physiol. Gastrointest. Liver Physiol. 281, 865-869 (2001).
11. Tsukamoto, H.; She, H.; Hazra, S.; Cheng, J.; Wang, J. Fat paradox of steatohepatitis. J. Gastroenterol. Hepatol. 23, 104-107 (2008).
12. Iwamoto A, Egashira T, Takayama F, Yamanaka Y, Noguchi T. Change in free radical-related substances in plasma following ischemia-reperfusion in rat liver. Pathophysiology 8, 167-174 (2002).
13. Folch, J.; Lees, M.; Sloane, Stanly G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509 (1957).
14. Mankura, M.; Kayama, M.; Iijima, N. Metabolism of dietary fatty alcohol, fatty acid, and wax ester in carp. J. Jpn. Oil Chem. Soc. (Yukagaku) 36, 920-932 (1987).
15. Gentile, C. L.; Pagliassotti, M. J. The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. J. Nutr. Biochem. 19, 567-576 (2008).
16. Hiratsuka, S.; Ishihara, K.; Kitagawa, T.; Wada, S.; Yokogoshi, H. Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of the brain in mice. J. Nutr. Sci. Vitaminol. (Tokyo) 54, 501-506 (2008).
17. Savransky, V.; Nanayakkara, A.; Vivero, A.; Li, J.; Bevans, S.; Smith, P. L.; Torbenson, M.S.; Polotsky, V.Y. Chronic intermittent hypoxia predisposes to liver injury. Hepatology 45, 1007-1013 (2007).
18. She, H.; Xiong, S.; Hazra, S.; Tsukamoto, H. Adipogenic transcriptional regulation of hepatic stellate cells. J. Biol. Chem. 280, 4959-4967 (2005).
19. Calder, P. C. n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am. J. Clin. Nutr. 83, 1505-1519 (2006).
20. Musso, G.; Gambino, R.; De Michieli, F.; Cassader, M.; Rizzetto, M.; Durazzo, M.; Fagà, E.; Silli, B.; Pagano, G. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 37, 909-916 (2003).
21. Donnelly, K. L.; Smith, C. I.; Schwarzenberg, S. J.; Jessurun, J.; Boldt, M. D.; Parks, E. J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115, 1343-1351 (2005).
22. Serhan, C. N.; Chiang, N.; Van, Dyke TE. Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8, 349-361 (2008).
23. Serhan, C. N.; Yang, R.; Martinod, K.; Kasuga, K.; Pillai, P. S.; Porter, T. F.; Oh, S. F.; Spite, M. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. J. Exp. Med. 206, 15-23 (2009).
24. González-Périz, A.; Planagumà, A.; Gronert, K.; Miquel, R.; López-Parra M.; Titos, E.; Horrillo, R.; Ferré, N.; Deulofeu, R.; Arroyo, V.; Rodés, J.; Clària, J. Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: Protectin D1 and 17S-hydroxy-DHA. FASEB J. 20, 2537-2539 (2006).
25. Serhan, C. N.; Chiang, N. Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Br. J. Pharmacol. 153, 200-215 (2008).
26. González-Périz, A.; Horrillo, R.; Ferré, N.; Gronert, K.; Dong, B.; Morán-Salvador, E.; Titos, E.; Martínez-Clemente, M.; López-Parra, M.; Arroyo, V.; Clària, J. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J. 23, 1946-1957 (2009).
27. Ryan, A. S; Bailey-Hall, E; Nelson, E. B; Salem, N.Jr. The hypolipidemic effect of an ethyl ester of algal-docosahexaenoic acid in rats fed a high-fructose diet. Lipids 44, 817-826 (2009).