Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-A y mice

Lipids

Volumn 48, Issue 5, 2013, Pages 449-455

  Beppu, Fumiaki ^a   Hosokawa, Masashi ^a   Yim, Mi Jin ^a   Shinoda, Taro ^a   Miyashita, Kazuo ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Fucoxanthin; Hyperleptinemia KK A y mice; Leptin; Leptin deficient ob ob mice; Obesity; Stearoyl CoA desaturase 1

Indexed keywords

ACYL COENZYME A DESATURASE 1; FATTY ACID; FUCOXANTHIN; LEPTIN; MESSENGER RNA; OLEIC ACID; STEARIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; FEMALE; GENE EXPRESSION REGULATION; HYPERLEPTINEMIA; LIPID COMPOSITION; LIVER LEVEL; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SCD1 GENE; SIGNAL TRANSDUCTION; WEIGHT GAIN;

ANIMALS; BLOOD GLUCOSE; DOWN-REGULATION; FATTY ACIDS; FEMALE; LEPTIN; LIVER; MICE; MICE, OBESE; OBESITY; RNA, MESSENGER; SEAWEED; SIGNAL TRANSDUCTION; STEAROYL-COA DESATURASE; WEIGHT GAIN; XANTHOPHYLLS;

MUS;

EID: 84880574008     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-013-3784-4     Document Type: Article

References (24)

1. Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita K (2010) Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice. Arch Biochem Biophys 504:17-25
2. Tsukui T, Konno K, Hosokawa M, Maeda H, Sashima T, Miyashita K (2007) Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice. J Agric Food Chem 55:5025-5029 (Pubitemid 47056052)
3. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD (2002) Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 99:11482-11486 (Pubitemid 34920951)
4. Miyazaki M, Kim YC, Gray-Keller MP, Attie AD, Ntambi JM (2000) The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J Biol Chem 275:30132-30138
5. Kaestner KH, Ntambi JM, Kelly TJ Jr, Lane MD (1989) Differentiation- induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem 264:14755-14761 (Pubitemid 19237293)
6. Bjermo H, Risérus U (2010) Role of hepatic desaturases in obesity-related metabolic disorders. Curr Opin Clin Nutr Metab Care 13:703-708
7. Miyazaki M, Bruggink SM, Ntambi JM (2006) Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. J Lipid Res 47:700-704
8. Ntambi JM, Miyazaki M (2003) Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol 14:255-261 (Pubitemid 36688204)
9. Jiang G, Li Z, Liu F, Ellsworth K, Dallas-Yang Q, Wu M, Ronan J, Esau C, Murphy C, Szalkowski D, Bergeron R, Doebber T, Zhang BB (2005) Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J Clin Invest 115:1030-1038 (Pubitemid 40489408)
10. Miyazaki M, Sampath H, Liu X, Flowers MT, Chu K, Dobrzyn A, Ntambi JM (2009) Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun 380:818-822
11. Gautron L, Elmquist JK (2011) Sixteen years and counting: an update on leptin in energy balance. J Clin Invest 121:2087-2093
12. Myers MG, Cowley MA, Münzberg H (2008) Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70:537-556 (Pubitemid 351738191)
13. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM (2002) Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297:240-243 (Pubitemid 34761283)
14. Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K (2005) Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun 332:392-397 (Pubitemid 40724991)
15. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509
16. Prevot AF, Mordret FX (1976) Utilisation des colonnes capillaries de verre pour l'analyse des corps gras par chromotographie en phase gazeuse. Rev Fse Corps Gras 23:409-423 (in French)
17. Masuzaki H, Ogawa Y, Aizawa-Abe M, Hosoda K, Suga J, Ebihara K, Satoh N, Iwai H, Inoue G, Nishimura H, Yoshimasa Y, Nakao K (1999) Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes. Diabetes 48:1615-1622 (Pubitemid 29356871)
18. y mice. Phytomedicine 19:389-394
19. Flowers JB, Rabaglia ME, Schueler KL, Flowers MT, Lan H, Keller MP, Ntambi JM, Attie AD (2007) Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56:1228-1239 (Pubitemid 46715602)
20. Rahman SM, Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Ntambi JM (2003) Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci USA 100:11110-11115 (Pubitemid 37140160)
21. Rahman SM, Dobrzyn A, Lee SH, Dobrzyn P, Miyazaki M, Ntambi JM (2005) Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. Am J Physiol Endocrinol Metab 288:E381-E387 (Pubitemid 40110647)
22. Woo MN, Jeon SM, Kim HJ, Lee MK, Shin SK, Shin YC, Park YB, Choi MS (2010) Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6 N mice. Chem Biol Interact 186:316-322
23. Mauvoisin D, Prévost M, Ducheix S, Arnaud MP, Mounier C (2010) Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the stearoyl-CoA desaturase (SCD1) gene expression in response to leptin. Mol Cell Endocrinol 319:116-128
24. Biddinger SB, Miyazaki M, Boucher J, Ntambi JM, Kahn CR (2006) Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 55:2032-2041 (Pubitemid 44509977)