Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis

Journal of Hepatology

Volumn 39, Issue 5, 2003, Pages 756-764

  George, Jacob ^a,b   Pera, Natasha ^a   Phung, Nghi ^a   Leclercq, Isabelle ^a   Hou, Jing Yun ^a   Farrell, Geoffrey ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WESTMEAD HOSPITAL   (Australia)

Author keywords

Collagen; Hepatic fibrosis; Hepatocytes; Lipid peroxidation; Steatohepatitis; Stellate cells; Transforming growth factor beta

Indexed keywords

CHOLINE; COLLAGEN TYPE 1; CYTOKINE; GLUTATHIONE; MESSENGER RNA; METHIONINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL DAMAGE; CELL TYPE; CONTROLLED STUDY; FATTY LIVER; FIBROGENESIS; GENE EXPRESSION; HISTOPATHOLOGY; LIPID DIET; LIPID PEROXIDATION; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER PARENCHYMA; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; STELLATE CELL; UPREGULATION;

EID: 0242438087     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(03)00376-3     Document Type: Article

References (38)

1. Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui J, Fung C, et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002;35:373-379.
2. Chitturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001;21:27-41.
3. Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001;120:1183-1192.
4. Clark JM, Brancati FL, Diehl AM. Nonalcoholic fatty liver disease. Gastroenterology 2002;122:1649-1657.
5. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221-1231.
6. Samarasinghe DA, Farrell GC. The central role of sinusoidal endothelial cells in hepatic hypoxia-reoxygenation injury in the rat. Hepatology 1996;24:1230-1237.
7. Ramm GA. Isolation and culture of rat hepatic stellate cells. J Gastroenterol Hepatol 1998;13:846-851.
8. Lopez-De Leon A, Rojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 1985;33:737-743.
9. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358.
10. Hissin PJ, Hilf R. A fluorometric method for determination of oxidised and reduced glutathione in tissues. Anal Biochem 1976;74:214-226.
11. Jarnagin WR, Rockey C, Koteliansky VE, Wang SS, Bissell DM. Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol 1994;127:2037-2048.
12. Iredale JP, Benyon RC, Arthur MJP, Ferris WF, Alcolado R, Winwood PJ, et al. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology 1996;24:176-184.
13. Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJP. Expression of tissue inhibitor of metalloproteinases-1 and -2 is increased in human fibrotic liver. Gastroenterology 1996;110:821-831.
14. Maher JJ, McGuire RF. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 1990;86:1641-1648.
15. Rhoads DD, Dixit A, Roufa DJ. Primary structure of human ribosomal protein S14 and the gene that encodes it. Mol Cell Biol 1986;6:2774-2783.
16. Weltman MD, Farrell GC, Liddle C. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology 1996;111:1645-1653.
17. Weltman M. The role of cytochrome P4502E1 in NASH. PhD thesis, University of Sydney, 1999.
18. Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine noalcoholic steatohepatitis. J Clin Invest 2000;105:1067-1075.
19. Reid AE. Nonalcoholic steatohepatitis. Gastroenterology 2001;121:710-723.
20. Kirsch R, Shephard E, Kirsch R, Hall P. The rat nutritional model of non-alcoholic steatohepatitis: strain and gender studies. J Gastroenterol Hepatol 2000;15:F81.
21. Murray M, Zaluzny L, Farrell GC. Drug metabolism in cirrhosis. Selective changes in cytochrome P-450 isozymes in the choline-deficient rat model. Biochem Pharmacol 1986;35:1817-1824.
22. Rinella ME, Green RM. The methionine-choline deficient (MCD) diet model of NASH is associated with relative hypoglycemia and diminished serum insulin levels. Hepatology 2002;36:402A.
23. Lombardi B, Pani P, Schlunk FF. Choline-deficiency fatty liver: impaired release of hepatic triglycerides. J Lipid Res 1968;9:437-446.
24. Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci USA 2001;98:5560-5565.
25. Fan CY, Pan J, Usuda N, Yeldandi AV, Rao MS, Reddy JK. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem 1998;273:15639-15645.
26. MacDonald GA, Bridle KR, Ward PJ, Walker NI, Houglum K, George DK, et al. Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3. J Gastroenterol Hepatol 2001;16:599-606.
27. Seki S, Kitada T, Yamada T, Sakaguchi H, Nakaatani K, Wakasa K. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J Hepatol 2002;37:56-62.
28. Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2002;17:186-190.
29. Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 2000;343:1467-1476.
30. Parola M, Pinzani M, Casini A, Albano E, Poli G, Gentilini A, et al. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen α1 (I) gene expression in human liver fat-storing cells. Biochem Biophys Res Commun 1993;194:1044-1050.
31. Chojkier M, Houglum K, Solis-Herruzo J, Brenner DA. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation? J Biol Chem 1989;264:16957-16962.
32. Houglum K, Brenner DA, Chojkier M. D-α-Tocopherol inhibits collagen α1 (I) gene expression in cultured human fibroblasts. J Clin Invest 1991;87:2230-2235.
33. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGFα and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995;92:2461-2468.
34. Bissell DM, Roulot D, George J. Transforming growth factor β and the liver. Hepatology 2001;34:859-867.
35. Nakatsukasa H, Nagy P, Evarts RP, Hsia CC, Marsden E, Thorgeirsson SS. Cellular distribution of transforming growth factor beta 1 and procollagen types I, III and IV transcripts in carbon tetrachloride induced rat liver fibrosis. J Clin Invest 1990;85:1833-1843.
36. George J, Roulot D, Koteliansky VE, Bissell DM. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis. Proc Natl Acad Sci USA 1999;96:12719-12724.
37. George J, Wang SS, Sevcsik AM, Sanicola M, Cate RL, Koteliansky VE, et al. Transforming growth factor-β initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform. Am J Pathol 2000;156:115-124.
38. Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 1995;96:447-455.