메뉴 건너뛰기




Volumn 52, Issue 8, 2008, Pages 965-973

Dietary docosahexaenoic acid-rich diacylglycerols ameliorate hepatic steatosis and alter hepatic gene expressions in C57BL/6J-Lepob/ob mice

Author keywords

C57bl 6j Lepob ob; Diacylglycerol; Docosahexaenoic acid; Hepatic steatosis; Structured lipid

Indexed keywords

ALGAE; ANIMALIA; GLYCINE MAX; MUS;

EID: 54549120218     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700315     Document Type: Article
Times cited : (28)

References (40)
  • 1
    • 1842580567 scopus 로고    scopus 로고
    • Boer, M.-Den., Voshol, P.-J., Kuipers, F., Havekes, L.-M., Romijn, J.-A., Hepatic steatosis a mediator of the metabolic syndrome, lessons from animal models, Arterioscler. Thromb. Vasc. Biol. 2003, 24, 644-649.
    • Boer, M.-Den., Voshol, P.-J., Kuipers, F., Havekes, L.-M., Romijn, J.-A., Hepatic steatosis a mediator of the metabolic syndrome, lessons from animal models, Arterioscler. Thromb. Vasc. Biol. 2003, 24, 644-649.
  • 2
    • 33644821463 scopus 로고    scopus 로고
    • Diacylglycerol: Efficacy and mechanism of action of an anti-obesity agent
    • Rudkowska, I., Roynette, C.-E., Demonty, I., Vanstone, C.-A., et al., Diacylglycerol: Efficacy and mechanism of action of an anti-obesity agent, Obes. Res. 2005, 13, 1864-1876.
    • (2005) Obes. Res , vol.13 , pp. 1864-1876
    • Rudkowska, I.1    Roynette, C.-E.2    Demonty, I.3    Vanstone, C.-A.4
  • 3
    • 0035700673 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids and cardiovascular diseases
    • Nordøy, A., Marchioli, R., Arnesen, H., Videbaek, J., N-3 polyunsaturated fatty acids and cardiovascular diseases, Lipids 2001, 36, S127-S129.
    • (2001) Lipids , vol.36
    • Nordøy, A.1    Marchioli, R.2    Arnesen, H.3    Videbaek, J.4
  • 4
    • 0344329878 scopus 로고    scopus 로고
    • Health benefits of docosahexaenoic acid (DHA)
    • Horrocks, L.-A., Yeo, Y.-K., Health benefits of docosahexaenoic acid (DHA), Pharmacol. Res. 1999, 40, 211-225.
    • (1999) Pharmacol. Res , vol.40 , pp. 211-225
    • Horrocks, L.-A.1    Yeo, Y.-K.2
  • 5
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M., Barone, M., et al., Positional cloning of the mouse obese gene and its human homologue, Nature 1994, 372, 425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4
  • 6
    • 0029960052 scopus 로고    scopus 로고
    • Effect of polyunsaturated fatty acids in obese mice
    • Clandinin, M.-T., Cheema, S., Pehowich, D., Field, C.-J., Effect of polyunsaturated fatty acids in obese mice, Lipids 1996, 31 (Suppl.2), 13-22.
    • (1996) Lipids , vol.31 , Issue.SUPPL.2 , pp. 13-22
    • Clandinin, M.-T.1    Cheema, S.2    Pehowich, D.3    Field, C.-J.4
  • 7
    • 54549120627 scopus 로고    scopus 로고
    • Synthesis of diacylglycerol-enriched functional lipid containing DHA by lipase-catalyzed in solvent-free system
    • Kim, N.-S., Lee, K.-T., Synthesis of diacylglycerol-enriched functional lipid containing DHA by lipase-catalyzed in solvent-free system, Korean J. Food Sci. Technol. 2005, 37, 584-589.
    • (2005) Korean J. Food Sci. Technol , vol.37 , pp. 584-589
    • Kim, N.-S.1    Lee, K.-T.2
  • 8
    • 0017375321 scopus 로고
    • Report of the American Institute of Nutrition. ad hoc committee on standards for nutritional studies
    • American Institute of Nutrition
    • American Institute of Nutrition: Report of the American Institute of Nutrition. ad hoc committee on standards for nutritional studies, J. Nutr. 1977, 107, 1340-1348.
    • (1977) J. Nutr , vol.107 , pp. 1340-1348
  • 9
    • 1642468898 scopus 로고
    • Report of ad hoc committee on standards for nutritional studies
    • American Institute of Nutrition
    • American Institute of Nutrition: Report of ad hoc committee on standards for nutritional studies, J. Nutr. 1980, 110, 1717-1726.
    • (1980) J. Nutr , vol.110 , pp. 1717-1726
  • 11
    • 0020680990 scopus 로고
    • A peroxidase-coupled method for the colorimetric determination of serum triglycerides
    • McGowan, M.-W., Artiss, J.-D., Strandbergh, D.-R., Zak, B., A peroxidase-coupled method for the colorimetric determination of serum triglycerides, Clin. Chem. 1983, 29, 538-542.
    • (1983) Clin. Chem , vol.29 , pp. 538-542
    • McGowan, M.-W.1    Artiss, J.-D.2    Strandbergh, D.-R.3    Zak, B.4
  • 12
    • 70449158340 scopus 로고
    • A simple method for isolation and purification of total lipids from animal tissues
    • Folch, J., Lees, M., Sloan-Stanley, G.-H., A simple method for isolation and purification of total lipids from animal tissues, J. Biol. Chem. 1957, 226, 497-509.
    • (1957) J. Biol. Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloan-Stanley, G.-H.3
  • 13
    • 0015911095 scopus 로고
    • Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A
    • Hulcher, F.-H., Oleson,W.-H., Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A, J. Lipid Res. 1973, 14, 625-631.
    • (1973) J. Lipid Res , vol.14 , pp. 625-631
    • Hulcher, F.-H.1    Oleson, W.-H.2
  • 16
    • 0022273575 scopus 로고
    • Mg2-dependent phosphatidate phosphohydrolase of rat lung: Development of an assay employing a defined chemical substrate which reflects the phosphohydrolase activity measured using membrane-bound substrate
    • Walton, P.-A., Possmayer, F., Mg2-dependent phosphatidate phosphohydrolase of rat lung: development of an assay employing a defined chemical substrate which reflects the phosphohydrolase activity measured using membrane-bound substrate, Anal. Biochem. 1985, 151, 479-486.
    • (1985) Anal. Biochem , vol.151 , pp. 479-486
    • Walton, P.-A.1    Possmayer, F.2
  • 17
    • 0015848170 scopus 로고
    • The subcellular distribution of carnitine acyltransferases in mammalian liver and kidney
    • Markwell, M.-A.-K., McGroarty, E.-J., Bieber, L.-L., Tolbert, N.-E., The subcellular distribution of carnitine acyltransferases in mammalian liver and kidney, J. Biol. Chem. 1973, 248, 3426-3432.
    • (1973) J. Biol. Chem , vol.248 , pp. 3426-3432
    • Markwell, M.-A.-K.1    McGroarty, E.-J.2    Bieber, L.-L.3    Tolbert, N.-E.4
  • 18
    • 0019742075 scopus 로고
    • Assay of peroxisomal β-oxidation of fatty acids
    • Lazarow, P.-B., Assay of peroxisomal β-oxidation of fatty acids, Methods Enzymol. 1981, 72, 315-319.
    • (1981) Methods Enzymol , vol.72 , pp. 315-319
    • Lazarow, P.-B.1
  • 20
    • 0019122496 scopus 로고
    • Rat liver acyl-coenzyme A:cholesterol acyltransferase: Its regulation in vivo and some of properties in vitro
    • Erickson, S.-K., Schrewsbery, M.-A., Brooks, C., Meyer, D.-J., Rat liver acyl-coenzyme A:cholesterol acyltransferase: its regulation in vivo and some of properties in vitro, J. Lipid Res. 1980, 21, 930-941.
    • (1980) J. Lipid Res , vol.21 , pp. 930-941
    • Erickson, S.-K.1    Schrewsbery, M.-A.2    Brooks, C.3    Meyer, D.-J.4
  • 21
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.-M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 1976, 72, 248-254.
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Bradford, M.-M.1
  • 23
    • 0032814457 scopus 로고    scopus 로고
    • Regulation of gene expression by dietary fat
    • Jump, D.-B., Clarke, S.-D., Regulation of gene expression by dietary fat, Annu. Rev. Nutr. 1999, 19, 63-90.
    • (1999) Annu. Rev. Nutr , vol.19 , pp. 63-90
    • Jump, D.-B.1    Clarke, S.-D.2
  • 24
    • 0142091723 scopus 로고    scopus 로고
    • A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: Relationship to anti-obesity
    • Nakatani, T., Kim, H.-J., Kaburagi, Y., Yasuda, K., Ezaki, O., A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: relationship to anti-obesity, J. Lipid Res. 2003, 44, 369-379.
    • (2003) J. Lipid Res , vol.44 , pp. 369-379
    • Nakatani, T.1    Kim, H.-J.2    Kaburagi, Y.3    Yasuda, K.4    Ezaki, O.5
  • 25
    • 1542273633 scopus 로고    scopus 로고
    • Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue
    • Meng, X., Zou, D., Shi, Z., Duan, Z., Mao, Z., Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue, Lipids 2004, 39, 37-41.
    • (2004) Lipids , vol.39 , pp. 37-41
    • Meng, X.1    Zou, D.2    Shi, Z.3    Duan, Z.4    Mao, Z.5
  • 26
    • 0032926382 scopus 로고    scopus 로고
    • Influence of obesity and body fat distribution on postprandial lipemia and triglyceride-rich lipoproteins in adult women
    • Mekki, N., Christofilis, M.-A., Charbonnier, M., Atlan-Gepner, C., et al., Influence of obesity and body fat distribution on postprandial lipemia and triglyceride-rich lipoproteins in adult women, J. Clin. Endocrinol. Metab. 1999, 84, 184-191.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , pp. 184-191
    • Mekki, N.1    Christofilis, M.-A.2    Charbonnier, M.3    Atlan-Gepner, C.4
  • 27
    • 0035719818 scopus 로고    scopus 로고
    • The differential hepatic uptake of chylomicron remnants of different fatty acid composition is not mediated by hepatic lipase
    • Lambert, M.-S., Avella, M.-A., Berhane, Y., Shervill, E., Botham, K.-M., The differential hepatic uptake of chylomicron remnants of different fatty acid composition is not mediated by hepatic lipase, Br. J. Nutr. 2001, 85, 575-582.
    • (2001) Br. J. Nutr , vol.85 , pp. 575-582
    • Lambert, M.-S.1    Avella, M.-A.2    Berhane, Y.3    Shervill, E.4    Botham, K.-M.5
  • 28
    • 0030790270 scopus 로고    scopus 로고
    • Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipoprotein lipase
    • Harris, W.-S., Lu, G.-P., Rambjor, G.-S., Walen, A.-I., Ontko, J.-A., Influence of n-3 fatty acid supplementation on the endogenous activities of plasma lipoprotein lipase, Am. J. Clin. Nutr. 1997, 66, 254-260.
    • (1997) Am. J. Clin. Nutr , vol.66 , pp. 254-260
    • Harris, W.-S.1    Lu, G.-P.2    Rambjor, G.-S.3    Walen, A.-I.4    Ontko, J.-A.5
  • 29
    • 0021333269 scopus 로고
    • The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver
    • Wong, S.-H., Nestel, P.-J., Trimble, R.-P., Storer, G.-B., Illman, R.-J., Topping, D.-L., The adaptive effects of dietary fish and safflower oil on lipid and lipoprotein metabolism in perfused rat liver, Biochim. Biophys. Acta 1984, 792, 103-109.
    • (1984) Biochim. Biophys. Acta , vol.792 , pp. 103-109
    • Wong, S.-H.1    Nestel, P.-J.2    Trimble, R.-P.3    Storer, G.-B.4    Illman, R.-J.5    Topping, D.-L.6
  • 30
    • 0030914498 scopus 로고    scopus 로고
    • Reciprocal responses to dietary diacylglycerol of hepatic enzymes of fatty acid synthesis and oxidation in the rat
    • Murata, M., Ide, T., Hara, K., Reciprocal responses to dietary diacylglycerol of hepatic enzymes of fatty acid synthesis and oxidation in the rat, Br. J. Nutr. 1997, 77, 107-121.
    • (1997) Br. J. Nutr , vol.77 , pp. 107-121
    • Murata, M.1    Ide, T.2    Hara, K.3
  • 31
    • 0036849838 scopus 로고    scopus 로고
    • Dietary diacylglycerol suppresses high fat diet-induced hepatic fat accumulation and microsomal triacylglycerol transfer protein activity in rats
    • Taguchi, H., Omachi, T., Nagao, T., Matsuo, N., et al., Dietary diacylglycerol suppresses high fat diet-induced hepatic fat accumulation and microsomal triacylglycerol transfer protein activity in rats, J. Nutr. Biochem. 2002, 13, 678-683.
    • (2002) J. Nutr. Biochem , vol.13 , pp. 678-683
    • Taguchi, H.1    Omachi, T.2    Nagao, T.3    Matsuo, N.4
  • 32
    • 33744827394 scopus 로고    scopus 로고
    • Diacylglycerol-enriched structured lipids containing CLA and capric acid alter body fat mass and lipid metabolism in rats
    • Kim, H.-J., Lee, K.-T., Lee, M.-K., Jeon, S.-M., Choi, M.-S., Diacylglycerol-enriched structured lipids containing CLA and capric acid alter body fat mass and lipid metabolism in rats, Ann. Nutr. Metab. 2006, 50, 219-228.
    • (2006) Ann. Nutr. Metab , vol.50 , pp. 219-228
    • Kim, H.-J.1    Lee, K.-T.2    Lee, M.-K.3    Jeon, S.-M.4    Choi, M.-S.5
  • 33
    • 33646050944 scopus 로고    scopus 로고
    • Spray-dried milk supplemented with alpha linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG-CoA reductase activity and increases biliary secretion of lipids in rats
    • Ramaprasad, T.-R., Srinivasan, K., Baskaran, V., Sambaiah, K., Lokesh, B.-R., Spray-dried milk supplemented with alpha linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG-CoA reductase activity and increases biliary secretion of lipids in rats, Steroids 2006, 71, 409-415.
    • (2006) Steroids , vol.71 , pp. 409-415
    • Ramaprasad, T.-R.1    Srinivasan, K.2    Baskaran, V.3    Sambaiah, K.4    Lokesh, B.-R.5
  • 34
    • 0345448923 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
    • Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., et al., Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression, Hepatology 2003, 38, 1529-1539.
    • (2003) Hepatology , vol.38 , pp. 1529-1539
    • Sekiya, M.1    Yahagi, N.2    Matsuzaka, T.3    Najima, Y.4
  • 35
    • 0037205433 scopus 로고    scopus 로고
    • Absence of SREBP-1 ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice
    • Yahagi, N., Shimano, H., Hasty, A.-H., Matsuzaka, T., et al., Absence of SREBP-1 ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice, J. Biol. Chem. 2002, 277, 19353-19357.
    • (2002) J. Biol. Chem , vol.277 , pp. 19353-19357
    • Yahagi, N.1    Shimano, H.2    Hasty, A.-H.3    Matsuzaka, T.4
  • 36
    • 0033520484 scopus 로고    scopus 로고
    • Fish oil feeding decreases mature SREBP-1 by down-regulation of SREBP-1c mRNA in mouse liver
    • Kim, H.-J., Takahashi, M., Ezaki, O., Fish oil feeding decreases mature SREBP-1 by down-regulation of SREBP-1c mRNA in mouse liver, J. Biol. Chem. 1999, 274, 25892-25898.
    • (1999) J. Biol. Chem , vol.274 , pp. 25892-25898
    • Kim, H.-J.1    Takahashi, M.2    Ezaki, O.3
  • 37
    • 0141446024 scopus 로고    scopus 로고
    • Liver PPARgamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    • Gavrilova, O., Haluzik, M., Matsusue, K., Cutson, J.-J., et al., Liver PPARgamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass, J. Biol. Chem. 2003, 278, 34268-34276.
    • (2003) J. Biol. Chem , vol.278 , pp. 34268-34276
    • Gavrilova, O.1    Haluzik, M.2    Matsusue, K.3    Cutson, J.-J.4
  • 38
    • 0033695790 scopus 로고    scopus 로고
    • Up-regulation of PPAR-alpha and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity:troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice
    • Memon, R.-A., Tecott, L.-H., Nonogaki, K., Beigneux, A., Moser, A.-H., Up-regulation of PPAR-alpha and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity:troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice, Endocrinology 2000, 141, 4021-4031.
    • (2000) Endocrinology , vol.141 , pp. 4021-4031
    • Memon, R.-A.1    Tecott, L.-H.2    Nonogaki, K.3    Beigneux, A.4    Moser, A.-H.5
  • 39
    • 0034796418 scopus 로고    scopus 로고
    • Hepatic over-expression of PPAR-gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus
    • Rahimian, R., Masih-Khan, E., Lo, M., van Breemen, C., Hepatic over-expression of PPAR-gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus, Mol. Cell. Biochem. 2001, 24, 29-37.
    • (2001) Mol. Cell. Biochem , vol.24 , pp. 29-37
    • Rahimian, R.1    Masih-Khan, E.2    Lo, M.3    van Breemen, C.4
  • 40
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for PPARalpha and delta
    • Forman, B.-M., Chen, J., Evans, R.-M., Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for PPARalpha and delta, Proc. Natl. Acad. Sci. 1997, 94, 4312-4317.
    • (1997) Proc. Natl. Acad. Sci , vol.94 , pp. 4312-4317
    • Forman, B.-M.1    Chen, J.2    Evans, R.-M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.