Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat-high-fructose diet-fed mice

Pharmaceutical Biology

Volumn 51, Issue 7, 2013, Pages 815-824

  Arunkumar, Elumalai ^a   Karthik, Dhanapalan ^a   Anuradha, Carani Venkatraman ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Adenosine monophosphate activated protein kinase; IRS PI3K Akt pathway; Lipid metabolism; Liver

Indexed keywords

ADENOSINE KINASE; ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; DIMETHYL SULFOXIDE; GENISTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG;

AMPK GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; DOWN REGULATION; DRUG TARGETING; ENZYME INHIBITION; EXPERIMENTAL MOUSE; FATTY ACID OXIDATION; GENE; GENE CONTROL; HIGH FAT HIGH FRUCTOS DIET; IRS 1 GENE; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIPID STORAGE; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PI3K GENE; PROTEIN PHOSPHORYLATION; QUANTITATIVE STUDY; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WEIGHT GAIN; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; DIET, HIGH-FAT; DOWN-REGULATION; FATTY ACIDS; FRUCTOSE; GENISTEIN; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; LIVER; MALE; MICE; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; UP-REGULATION;

ANIMALIA; MUS;

EID: 84879353742     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.766896     Document Type: Article

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