Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis

International Journal of Molecular Medicine

Volumn 30, Issue 3, 2012, Pages 673-679

  Kuo, Jong Jen ^a,b   Chang, Hen Hong ^a,b   Tsai, Tung Hu ^a   Lee, Tzung Yan ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Curcumin; Inflammation; Liver steatosis; Mitochondrial dysfunction; Obesity

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIINFLAMMATORY AGENT; CURCUMIN; INTERLEUKIN 6; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR RESPIRATORY FACTOR 1; STAT3 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUPPRESSOR OF CYTOKINE SIGNALING 3; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVITY; EPIDIDYMIS FAT; FATTY LIVER; GENE EXPRESSION; MACROPHAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; CURCUMIN; CYTOKINES; FATTY LIVER; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MITOCHONDRIA; OBESITY; SIGNAL TRANSDUCTION;

EID: 84865197360     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.1049     Document Type: Article

References (29)

1. Després JP and Lemieux I: Abdominal obesity and metabolic syndrome. Nature 444: 881-887, 2006.
2. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL and Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808, 2003. (Pubitemid 38063703)
3. Wu H, Perrard XD, Wang Q, Perrard JL, Polsani VR, Jones PH, Smith CW and Ballantyne CM: CD11c expression in adipose tissue and blood and its role in diet-induced obesity. Arterioscler Thromb Vasc Biol 30: 186-192, 2010.
4. Sanyal AJ: AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 123: 1705-1725, 2002.
5. Fabbrini E, Sullivan S and Klein S: Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 51: 679-689, 2010.
6. Tilg H and Moschen AR: Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52: 1836-1846, 2010.
7. Wang S, Kama t A, Pergola P, Swamy A, Tio F and Cusi K: Metabolic factors in the development of hepatic steatosis and altered mitochondrial gene expression in vivo. Metabolism 60: 1090-1099, 2011.
8. Chen J, Liu D, Bai Q, Song J, Guan J, Gao J, Liu B, Ma X and Du Y: Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. Mol Med Rep 4: 811-816, 2011.
9. Hsieh PS, Lu KC, Chiang CF and Chen CH: Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats. Eur J Clin Invest 40: 164-171, 2010.
10. Shishodia S, Sethi G and Aggarwal BB: Curcumin: getting back to the roots. Ann NY Acad Sci 1056: 206-217, 2005. (Pubitemid 43030979)
11. Yekollu SK, Thomas R and O'Sullivan B: Targeting curcusomes to inflammatory dendritic cells inhibits NF-κB and improves insulin resistance in obese mice. Diabetes 60: 2928-2938, 2011.
12. Weisberg SP, Leibel R and Tortoriello DV: Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 149: 3549-3558, 2008. (Pubitemid 351919581)
13. Koteish A and Mae Diehl A: Animal models of steatohepatitis. Best Pract Res Clin Gastroenterol 16: 679-690, 2002.
14. Lee TY, Chen FY, Chang HH and Lin HC: The effect of capillarisin on glycochenodexcholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes. Mol Cell Biochem 325: 53-59, 2009.
15. Lee TY, Chang HH, Chen JH, Hsueh ML and Kuo JJ: Herb medicine Yin-Chen-Hao-Tang ameliorates hepatic fibrosis in bile duct ligation rats. J Ethnopharmacol 109: 318-324, 2007.
16. Tedesco L, Valerio A, Cervino C, Cardile A, Pagano C, Vettor R, Pasquali R, Carruba MO, Marsicano G, Lutz B, et al: Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes. Diabetes 57: 2028-2036, 2008.
17. González R, Ferrín G, Hidalgo AB, Ranchal I, López-Cillero P, Santos-Gónzalez M, López-Lluch G, Briceño J, Gómez MA, Poyato A, et al: N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Chem Biol Interact 181: 95-106, 2009.
18. Hotamisligil GS: Inflammation and metabolic disorders. Nature 444: 860-867, 2006.
19. Shoelson SE, Herrero L and Naaz A: Obesity, inflammation, and insulin resistance. Gastroenterology 132: 2169-2180, 2007. (Pubitemid 46693756)
20. Postic C and Girard J: Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 118: 829-838, 2008. (Pubitemid 351364588)
21. Parekh S and Anania FA: Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology 132: 2191-2207, 2007. (Pubitemid 46693752)
22. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J and Karin M: IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11: 191-198, 2005. (Pubitemid 40321355)
23. Arafa HM: Curcumin attenuates diet-induced hypercholesterolemia in rats. Med Sci Monit 11: 228-234, 2005.
24. Shehzad A, Ha T, Subhan F and Lee YS: New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr 50: 151-161, 2011.
25. Leclercq IA, Farrell GC, Sempoux C, dela Peña A and Horsmans Y: Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol 41: 926-934, 2004. (Pubitemid 39575659)
26. Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, et al: Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat Med 10: 168-174, 2004. (Pubitemid 38524887)
27. Ueki K, Kadowaki T and Kahn CR: Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome. Hepatol Res 33: 185-192, 2005. (Pubitemid 41799802)
28. Demeilliers C, Maisonneuve C, Grodet A, Mansouri A, Nguyen R, Tinel M, Lettéron P, Degott C, Feldmann G, Pessayre D and Fromenty B: Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice. Gastroenterology 123: 1278-1290, 2002.
29. Li JM, Li YC, Kong LD and Hu QH: Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 51: 1555-1566, 2010.