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Volumn 46, Issue 5, 2008, Pages 1555-1569

Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells

Author keywords

Apigenin; Flavonoids; Kaempferol; Liver; Quercetin; Taxifolin

Indexed keywords

APIGENIN; CYTOKINE; FLAVONOID; GLUTATHIONE; GLUTATHIONE DISULFIDE; KAEMPFEROL; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; NITRIC OXIDE; PEROXIDE; QUERCETIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TAXIFOLIN;

EID: 40849085134     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.12.014     Document Type: Article
Times cited : (111)

References (57)
  • 1
    • 33646512855 scopus 로고    scopus 로고
    • Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide
    • Alia M., Ramos S., Mateos R., Granado-Serrano A.B., Bravo L., and Goya L. Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide. Toxicol. Appl. Pharmacol. 21 (2006) 110-118
    • (2006) Toxicol. Appl. Pharmacol. , vol.21 , pp. 110-118
    • Alia, M.1    Ramos, S.2    Mateos, R.3    Granado-Serrano, A.B.4    Bravo, L.5    Goya, L.6
  • 3
    • 0036586887 scopus 로고    scopus 로고
    • Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line
    • Banerjee T., Van der Vliet A., and Ziboh V.A. Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. Prostag. Leukotr. Essent. Fatty Acid 66 (2002) 485-492
    • (2002) Prostag. Leukotr. Essent. Fatty Acid , vol.66 , pp. 485-492
    • Banerjee, T.1    Van der Vliet, A.2    Ziboh, V.A.3
  • 4
    • 0033391238 scopus 로고    scopus 로고
    • Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rats
    • Breinholt V., Lauridsen S.T., and Dragsted L.O. Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rats. Xenobiotica 29 (1999) 1227-1240
    • (1999) Xenobiotica , vol.29 , pp. 1227-1240
    • Breinholt, V.1    Lauridsen, S.T.2    Dragsted, L.O.3
  • 5
    • 33749258585 scopus 로고    scopus 로고
    • Part of the series: from dietary antioxidants to regulators in cellular signalling and gene regulation
    • Brigelius-Flohe R., and Banning A. Part of the series: from dietary antioxidants to regulators in cellular signalling and gene regulation. Free Radic. Biol. Med. 40 (2006) 775-787
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 775-787
    • Brigelius-Flohe, R.1    Banning, A.2
  • 6
  • 7
    • 14744294057 scopus 로고    scopus 로고
    • In vivo quercitrin anti-inflammatory effect involves releases of quercetin, which inhibits inflammation through down-regulation of NF-κB pathway
    • Comalada M., Camuesco D., Sierra S., Ballester I., Xaus J., Galvez J., and Zarzuelo A. In vivo quercitrin anti-inflammatory effect involves releases of quercetin, which inhibits inflammation through down-regulation of NF-κB pathway. Eur. J. Immunol. 35 (2005) 584-592
    • (2005) Eur. J. Immunol. , vol.35 , pp. 584-592
    • Comalada, M.1    Camuesco, D.2    Sierra, S.3    Ballester, I.4    Xaus, J.5    Galvez, J.6    Zarzuelo, A.7
  • 9
    • 0035865879 scopus 로고    scopus 로고
    • Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation
    • Galati G., Moridani M.Y., Chan T.S., and O'Brien P.J. Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation. Free Radic. Biol. Med. 34 (2001) 370-382
    • (2001) Free Radic. Biol. Med. , vol.34 , pp. 370-382
    • Galati, G.1    Moridani, M.Y.2    Chan, T.S.3    O'Brien, P.J.4
  • 10
    • 3042574709 scopus 로고    scopus 로고
    • Potential toxicity of flavonoids and other dietary phenolics: significance for their chemoprotective and anticancer properties
    • Galati G., and O'Brien P.J. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemoprotective and anticancer properties. Free Radic. Biol. Med. 37 (2004) 287-303
    • (2004) Free Radic. Biol. Med. , vol.37 , pp. 287-303
    • Galati, G.1    O'Brien, P.J.2
  • 11
    • 1942474582 scopus 로고    scopus 로고
    • Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats
    • Galisteo M., García Saura M.F., Jiménez R., Villar I.C., Zarzuelo A., Vargas F., and Duarte J. Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats. Mol. Cell Biochem. 259 (2004) 91-99
    • (2004) Mol. Cell Biochem. , vol.259 , pp. 91-99
    • Galisteo, M.1    García Saura, M.F.2    Jiménez, R.3    Villar, I.C.4    Zarzuelo, A.5    Vargas, F.6    Duarte, J.7
  • 13
    • 33846582444 scopus 로고    scopus 로고
    • Anti-inflammatory effect of the flavones quercetin and kaempferol in Chang Liver cells involves inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway
    • García-Mediavilla V., Crespo I., Collado P.S., Esteller A., Sánchez-Campo S., Tuñón M.J., and González-Gallego J. Anti-inflammatory effect of the flavones quercetin and kaempferol in Chang Liver cells involves inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway. Eur. J. Pharmacol. 557 (2007) 221-229
    • (2007) Eur. J. Pharmacol. , vol.557 , pp. 221-229
    • García-Mediavilla, V.1    Crespo, I.2    Collado, P.S.3    Esteller, A.4    Sánchez-Campo, S.5    Tuñón, M.J.6    González-Gallego, J.7
  • 14
    • 0242495682 scopus 로고    scopus 로고
    • Polyphenolic antioxidants inhibit peptide presentation by antigen-presenting cells
    • Gong J., and Chen S.S. Polyphenolic antioxidants inhibit peptide presentation by antigen-presenting cells. Int. Immunopharmacol. 3 (2003) 1841-1852
    • (2003) Int. Immunopharmacol. , vol.3 , pp. 1841-1852
    • Gong, J.1    Chen, S.S.2
  • 15
    • 33646232728 scopus 로고    scopus 로고
    • Oxidative stress induced by Cremophor EL is not accompanied by changes in NF-κB activation or iNOS expression
    • Gutiérrez M.B., Miguel B.S., Villares C., Tuñón M.J., and González-Gallego J. Oxidative stress induced by Cremophor EL is not accompanied by changes in NF-κB activation or iNOS expression. Toxicology 222 (2006) 125-131
    • (2006) Toxicology , vol.222 , pp. 125-131
    • Gutiérrez, M.B.1    Miguel, B.S.2    Villares, C.3    Tuñón, M.J.4    González-Gallego, J.5
  • 17
    • 0036589679 scopus 로고    scopus 로고
    • Protection of flavonoids against lipid peroxidation: the structure-activity relationship revisited
    • Heijnen C.J.M., Haenen G.R.M.M., Oostveen R.M., Stalpers E.M., and Bast A. Protection of flavonoids against lipid peroxidation: the structure-activity relationship revisited. Free Radic. Res. 36 (2002) 575-581
    • (2002) Free Radic. Res. , vol.36 , pp. 575-581
    • Heijnen, C.J.M.1    Haenen, G.R.M.M.2    Oostveen, R.M.3    Stalpers, E.M.4    Bast, A.5
  • 18
    • 0017064979 scopus 로고
    • Fluorimetric method for determination of oxidised and reduced glutathione in tissues
    • Hissin J., and Hill R.A. Fluorimetric method for determination of oxidised and reduced glutathione in tissues. Anal. Biochem. 74 (1976) 214-226
    • (1976) Anal. Biochem. , vol.74 , pp. 214-226
    • Hissin, J.1    Hill, R.A.2
  • 19
    • 33744996911 scopus 로고    scopus 로고
    • Flavonoid-induced glutathione depletion: potential implications for cancer treatment
    • Kachadourian R., and Day B.J. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic. Biol. Med. 41 (2006) 65-76
    • (2006) Free Radic. Biol. Med. , vol.41 , pp. 65-76
    • Kachadourian, R.1    Day, B.J.2
  • 20
    • 1442324406 scopus 로고    scopus 로고
    • Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis
    • Keller T., Plesková M., McDonald M.C., Thiemermann C., Pfeilschifter J., and Beck K.F. Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis. Nitric Oxide 9 (2003) 183-193
    • (2003) Nitric Oxide , vol.9 , pp. 183-193
    • Keller, T.1    Plesková, M.2    McDonald, M.C.3    Thiemermann, C.4    Pfeilschifter, J.5    Beck, K.F.6
  • 21
    • 23344443002 scopus 로고    scopus 로고
    • Flavonoids differentially modulate nitric oxide production pathways in lipopolysaccharide-activated RAW264.7 cells
    • Kim A.R., Cho J.Y., Zou Y., Choi J.S., and Chung H.Y. Flavonoids differentially modulate nitric oxide production pathways in lipopolysaccharide-activated RAW264.7 cells. Arch. Pharm. Res. 28 (2005) 297-304
    • (2005) Arch. Pharm. Res. , vol.28 , pp. 297-304
    • Kim, A.R.1    Cho, J.Y.2    Zou, Y.3    Choi, J.S.4    Chung, H.Y.5
  • 22
    • 11844279094 scopus 로고    scopus 로고
    • Dietary rutin, but not its aglycon quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression
    • Kwon K.H., Murakami A., Tanaka T., and Ohigashi H. Dietary rutin, but not its aglycon quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression. Biochem. Pharmacol. 69 (2005) 395-406
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 395-406
    • Kwon, K.H.1    Murakami, A.2    Tanaka, T.3    Ohigashi, H.4
  • 23
    • 9644295733 scopus 로고    scopus 로고
    • Curcumin inhibits NF-κB activation and reduces the severity of experimental steatohepatitis in mice
    • Leclercq I.A., Farell G.C., Sempoux C., De la Peña A., and Horsmans Y. Curcumin inhibits NF-κB activation and reduces the severity of experimental steatohepatitis in mice. J. Hepatol. 41 (2004) 926-934
    • (2004) J. Hepatol. , vol.41 , pp. 926-934
    • Leclercq, I.A.1    Farell, G.C.2    Sempoux, C.3    De la Peña, A.4    Horsmans, Y.5
  • 24
    • 33751186142 scopus 로고    scopus 로고
    • Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver
    • Libra A., Fernetti C., Lorusso V., Visigalli M., Anelli P.L., Satud F., Tiribelli C., and Pascolo L. Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. J. Pharmacol. Exp. Ther. 319 (2006) 809-817
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 809-817
    • Libra, A.1    Fernetti, C.2    Lorusso, V.3    Visigalli, M.4    Anelli, P.L.5    Satud, F.6    Tiribelli, C.7    Pascolo, L.8
  • 25
    • 33749519154 scopus 로고    scopus 로고
    • Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels
    • Lima C.F., Fernandes-Ferreira M., and Pereira-Wilson C. Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sci. 19 (2006) 2056-2068
    • (2006) Life Sci. , vol.19 , pp. 2056-2068
    • Lima, C.F.1    Fernandes-Ferreira, M.2    Pereira-Wilson, C.3
  • 26
    • 0036256859 scopus 로고    scopus 로고
    • Prevention of cellular ROS damage by isovitexin and related flavonoids
    • Lin C.M., Chen C.T., Lee H.H., and Lin J.K. Prevention of cellular ROS damage by isovitexin and related flavonoids. Planta Med. 68 (2002) 365-367
    • (2002) Planta Med. , vol.68 , pp. 365-367
    • Lin, C.M.1    Chen, C.T.2    Lee, H.H.3    Lin, J.K.4
  • 27
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 28
    • 20444424991 scopus 로고    scopus 로고
    • Quercetin prevents nitric oxide production and nuclear factor kappa B activation in interleukin-1β-activated rat hepatocytes
    • Martínez-Flórez S., Gutiérrez M.B., Sánchez-Campos S., González-Gallego J., and Tuñón M.J. Quercetin prevents nitric oxide production and nuclear factor kappa B activation in interleukin-1β-activated rat hepatocytes. J. Nutr. 135 (2005) 1359-1365
    • (2005) J. Nutr. , vol.135 , pp. 1359-1365
    • Martínez-Flórez, S.1    Gutiérrez, M.B.2    Sánchez-Campos, S.3    González-Gallego, J.4    Tuñón, M.J.5
  • 29
    • 33645470431 scopus 로고    scopus 로고
    • Antioxidants from Rabsodia japonica
    • Masuoka N., Isobe T., and Kubo I. Antioxidants from Rabsodia japonica. Phytother. Res. 20 (2006) 206-213
    • (2006) Phytother. Res. , vol.20 , pp. 206-213
    • Masuoka, N.1    Isobe, T.2    Kubo, I.3
  • 30
    • 19444369140 scopus 로고    scopus 로고
    • Citotoxicity of flavonoids towards cultured normal human cells
    • Matsuo M., Sasaki N., Saga K., and Kaneko T. Citotoxicity of flavonoids towards cultured normal human cells. Biol. Pharm. Bull. 28 (2005) 253-259
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 253-259
    • Matsuo, M.1    Sasaki, N.2    Saga, K.3    Kaneko, T.4
  • 31
    • 1542436560 scopus 로고    scopus 로고
    • Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver
    • Molina M.F., Sanchez Reus I., Iglesias I., and Benedi J. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol. Pharm. Bull. 26 (2003) 1398-1402
    • (2003) Biol. Pharm. Bull. , vol.26 , pp. 1398-1402
    • Molina, M.F.1    Sanchez Reus, I.2    Iglesias, I.3    Benedi, J.4
  • 33
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 35
    • 0001255456 scopus 로고    scopus 로고
    • 2)-induced NF-κB DNA binding activity and DNA damage in HepG2 cells
    • 2)-induced NF-κB DNA binding activity and DNA damage in HepG2 cells. Carcinogenesis 19 (1998) 1583-1589
    • (1998) Carcinogenesis , vol.19 , pp. 1583-1589
    • Musonda, C.A.1    Chipman, J.K.2
  • 36
    • 0037305472 scopus 로고    scopus 로고
    • Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes
    • Nanji A.A., Jokelainen K., Tipoe G.L., Rahemtulla A., Thomas P., and Dannenberg A.J. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes. Am. J. Physiol. 284 (2003) G321-G327
    • (2003) Am. J. Physiol. , vol.284
    • Nanji, A.A.1    Jokelainen, K.2    Tipoe, G.L.3    Rahemtulla, A.4    Thomas, P.5    Dannenberg, A.J.6
  • 38
    • 0033758778 scopus 로고    scopus 로고
    • Hepatoprotective effects of the flavonoid quercetin in rats with biliary obstruction
    • Peres W., Tuñón M.J., Mato S., Collado P.S., and González-Gallego J. Hepatoprotective effects of the flavonoid quercetin in rats with biliary obstruction. J. Hepatol. 33 (2000) 742-750
    • (2000) J. Hepatol. , vol.33 , pp. 742-750
    • Peres, W.1    Tuñón, M.J.2    Mato, S.3    Collado, P.S.4    González-Gallego, J.5
  • 39
    • 0036186641 scopus 로고    scopus 로고
    • Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry
    • Pfeilschifter J., Beck K.F., Eberhardt W., and Huwiler A. Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry. Kidney Int. 61 (2002) 809-815
    • (2002) Kidney Int. , vol.61 , pp. 809-815
    • Pfeilschifter, J.1    Beck, K.F.2    Eberhardt, W.3    Huwiler, A.4
  • 40
    • 0036187213 scopus 로고    scopus 로고
    • Dietary quercetin augments activator protein-1 and does not reduce nuclear factor-kappa B in the renal cortex of rats with established chronic glomerular disease
    • Rangan G.K., Wang Y., and Harris D.C. Dietary quercetin augments activator protein-1 and does not reduce nuclear factor-kappa B in the renal cortex of rats with established chronic glomerular disease. Nephron 90 (2002) 313-319
    • (2002) Nephron , vol.90 , pp. 313-319
    • Rangan, G.K.1    Wang, Y.2    Harris, D.C.3
  • 41
    • 0035846885 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1
    • Raso G.M., Meli R., Di Carlo G., Pacilio M., and Di Carlo R. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 68 (2001) 921-931
    • (2001) Life Sci. , vol.68 , pp. 921-931
    • Raso, G.M.1    Meli, R.2    Di Carlo, G.3    Pacilio, M.4    Di Carlo, R.5
  • 42
    • 0141958939 scopus 로고    scopus 로고
    • The effect of quercetin on the mRNA expression of antioxidant enzymes in hepatoma cells
    • Rohrdanz E., Bittner A., Tran-Thi Q.H., and Kahl R. The effect of quercetin on the mRNA expression of antioxidant enzymes in hepatoma cells. Arch. Toxicol. 77 (2003) 506-510
    • (2003) Arch. Toxicol. , vol.77 , pp. 506-510
    • Rohrdanz, E.1    Bittner, A.2    Tran-Thi, Q.H.3    Kahl, R.4
  • 43
    • 11844272614 scopus 로고    scopus 로고
    • Flavonoids and tyrosine nitration: structure activity relationship correlation with enthalpy of formation
    • Sadeghipour M., Terreux R., and Phipps J. Flavonoids and tyrosine nitration: structure activity relationship correlation with enthalpy of formation. Toxicol. In Vitro 19 (2005) 155-165
    • (2005) Toxicol. In Vitro , vol.19 , pp. 155-165
    • Sadeghipour, M.1    Terreux, R.2    Phipps, J.3
  • 44
    • 0242409583 scopus 로고    scopus 로고
    • Effects of flavonoids on the susceptibility of low density lipoprotein to oxidative modification
    • Safari M.R., and Sheikh H. Effects of flavonoids on the susceptibility of low density lipoprotein to oxidative modification. Prostag. Leukot. Essents. Fatty Acid 69 (2003) 73-77
    • (2003) Prostag. Leukot. Essents. Fatty Acid , vol.69 , pp. 73-77
    • Safari, M.R.1    Sheikh, H.2
  • 45
    • 0037099385 scopus 로고    scopus 로고
    • Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design
    • Sartor L., Pezzato E., Dell'Aica I., Caniato R., Biggin S., and Garbisa S. Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design. Biochem. Pharmacol. 64 (2002) 229-237
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 229-237
    • Sartor, L.1    Pezzato, E.2    Dell'Aica, I.3    Caniato, R.4    Biggin, S.5    Garbisa, S.6
  • 46
    • 0035490269 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: from bedside to proteomics
    • Seow T.K., Liang R.C.M., Leow C.K., and Chung M.C.M. Hepatocellular carcinoma: from bedside to proteomics. Proteomics 1 (2001) 1249-1263
    • (2001) Proteomics , vol.1 , pp. 1249-1263
    • Seow, T.K.1    Liang, R.C.M.2    Leow, C.K.3    Chung, M.C.M.4
  • 47
    • 33748744646 scopus 로고    scopus 로고
    • Quercetin prevents oxidative stress and NF-κB activation in liver of type 1 diabetic rats
    • Simões A., Porawski M., Alonso M., Collado P.S., Marroni N., and González-Gallego J. Quercetin prevents oxidative stress and NF-κB activation in liver of type 1 diabetic rats. J. Nutr. 135 (2005) 2299-2304
    • (2005) J. Nutr. , vol.135 , pp. 2299-2304
    • Simões, A.1    Porawski, M.2    Alonso, M.3    Collado, P.S.4    Marroni, N.5    González-Gallego, J.6
  • 48
    • 0033410209 scopus 로고    scopus 로고
    • Anti-and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linoleic acid
    • Sugihara N., Arakawa T., Ohnishi M., and Furuno K. Anti-and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linoleic acid. Free Radic. Biol. Med. 27 (1999) 1313-1323
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 1313-1323
    • Sugihara, N.1    Arakawa, T.2    Ohnishi, M.3    Furuno, K.4
  • 49
    • 31544441350 scopus 로고    scopus 로고
    • Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals
    • Surth Y.J., Kundu J.K., Na H.K., and Lee J.S. Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals. J. Nutr. 135 (2005) 2993S-3001S
    • (2005) J. Nutr. , vol.135
    • Surth, Y.J.1    Kundu, J.K.2    Na, H.K.3    Lee, J.S.4
  • 51
    • 0041695625 scopus 로고    scopus 로고
    • Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes
    • Tuñón M.J., Sánchez-Campos S., Gutiérrez B., Culebras M.J., and González-Gallego J. Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes. Biochem. Pharmacol. 66 (2003) 439-445
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 439-445
    • Tuñón, M.J.1    Sánchez-Campos, S.2    Gutiérrez, B.3    Culebras, M.J.4    González-Gallego, J.5
  • 52
    • 4544254544 scopus 로고    scopus 로고
    • A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-α production
    • Ueda H., Yamazaki C., and Yamazaki M. A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-α production. Biosci. Biotechnol. Biochem. 68 (2004) 119-125
    • (2004) Biosci. Biotechnol. Biochem. , vol.68 , pp. 119-125
    • Ueda, H.1    Yamazaki, C.2    Yamazaki, M.3
  • 53
    • 0034747144 scopus 로고    scopus 로고
    • Delivery of IκB superrepressor gene with adenovirus reduces early-alcohol-induced liver injury in rats
    • Uesugi T., Froh M., Arteel G.E., Bradford B.U., Gabele E., Wheeler M.D., and Thurman R.G. Delivery of IκB superrepressor gene with adenovirus reduces early-alcohol-induced liver injury in rats. Hepatology 34 (2001) 1149-1157
    • (2001) Hepatology , vol.34 , pp. 1149-1157
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Gabele, E.5    Wheeler, M.D.6    Thurman, R.G.7
  • 54
    • 25844509315 scopus 로고    scopus 로고
    • Inhibition of TPA-induced cyclooxygenase (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes
    • Van Dross R.T., Hong X., and Pelling J.C. Inhibition of TPA-induced cyclooxygenase (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. Mol. Carcinogen. 44 (2005) 83-91
    • (2005) Mol. Carcinogen. , vol.44 , pp. 83-91
    • Van Dross, R.T.1    Hong, X.2    Pelling, J.C.3
  • 55
    • 33747188963 scopus 로고    scopus 로고
    • Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells
    • Vargo M.A., Vosss O.H., Poutska F., Cardounel A.J., Grotewold E., and Doseff A.I. Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem. Pharmacol. 72 (2006) 681-692
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 681-692
    • Vargo, M.A.1    Vosss, O.H.2    Poutska, F.3    Cardounel, A.J.4    Grotewold, E.5    Doseff, A.I.6
  • 57
    • 0035578227 scopus 로고    scopus 로고
    • NF-κB and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells
    • Zhou H., Johnson A.P., and Rando T.A. NF-κB and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radic. Biol. Med. 31 (2001) 1405-1416
    • (2001) Free Radic. Biol. Med. , vol.31 , pp. 1405-1416
    • Zhou, H.1    Johnson, A.P.2    Rando, T.A.3


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