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Volumn 31, Issue 7, 2010, Pages 679-692

Review article: Omega-3 fatty acids - A promising novel therapy for non-alcoholic fatty liver disease

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; BETAINE; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; INSULIN; METFORMIN; OMEGA 3 FATTY ACID; PENTOXIFYLLINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYUNSATURATED FATTY ACID; PROBUCOL; RIMONABANT; SIBUTRAMINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TETRAHYDROLIPSTATIN; URSODEOXYCHOLIC ACID; ANTILIPEMIC AGENT;

EID: 77649216380     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2010.04230.x     Document Type: Review
Times cited : (185)

References (134)
  • 1
    • 66749106254 scopus 로고    scopus 로고
    • Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD)
    • Bellentani S, Marino M. Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD). Ann Hepatol 2009 8 (Suppl. 1 S4 8.
    • (2009) Ann Hepatol , vol.8 , Issue.SUPPL. 1 , pp. 4-8
    • Bellentani, S.1    Marino, M.2
  • 2
    • 0036176194 scopus 로고    scopus 로고
    • Update on nonalcoholic fatty liver disease
    • McCullough AJ. Update on nonalcoholic fatty liver disease. J Clin Gastroenterol 2002 34 : 255 262.
    • (2002) J Clin Gastroenterol , vol.34 , pp. 255-262
    • McCullough, A.J.1
  • 3
    • 16044363694 scopus 로고    scopus 로고
    • Clinical hepatology: Profile of an urban, hospital-based practice
    • Byron D, Minuk GY. Clinical hepatology: profile of an urban, hospital-based practice. Hepatology 1996 24 : 813 815.
    • (1996) Hepatology , vol.24 , pp. 813-815
    • Byron, D.1    Minuk, G.Y.2
  • 4
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome - A new worldwide definition
    • DOI 10.1016/S0140-6736(05)67402-8, PII S0140673605674028
    • Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus, Group. The metabolic syndrome - a new worldwide definition. Lancet 2005 9491 : 1059 1062. (Pubitemid 41338752)
    • (2005) Lancet , vol.366 , Issue.9491 , pp. 1059-1062
    • Alberti, K.G.M.M.1    Zimmet, P.2    Shaw, J.3
  • 5
    • 68949129467 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus
    • Prashanth M, Ganesh HK, Vima MV, et al. Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. J Assoc Physicians India 2009 57 : 205 210.
    • (2009) J Assoc Physicians India , vol.57 , pp. 205-210
    • Prashanth, M.1    Ganesh, H.K.2    Vima, M.V.3
  • 6
    • 34347402532 scopus 로고    scopus 로고
    • Effects of nonalcoholic fatty liver disease on the development of metabolic disorders
    • Fan JG, Li F, Cai XB, Peng YD, Ao QH, Gao Y. Effects of nonalcoholic fatty liver disease on the development of metabolic disorders. J Gastroenterol Hepatol 2007 22 : 1086 1091.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1086-1091
    • Fan, J.G.1    Li, F.2    Cai, X.B.3    Peng, Y.D.4    Ao, Q.H.5    Gao, Y.6
  • 7
    • 33644693579 scopus 로고    scopus 로고
    • Liver markers and development of the metabolic syndrome: The insulin resistance atherosclerosis study
    • Hanley AJ, Williams K, Festa A, Wagenknecht LE, D'Agostino RB Jr., Haffner SM. Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Diabetes 2005 54 : 3140 3147.
    • (2005) Diabetes , vol.54 , pp. 3140-3147
    • Hanley, A.J.1    Williams, K.2    Festa, A.3    Wagenknecht, L.E.4    D'Agostino, Jr.R.B.5    Haffner, S.M.6
  • 8
    • 34247647418 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease
    • Hamaguchi M, Kojima T, Takeda N, et al. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 2007 10 : 1579 1584.
    • (2007) World J Gastroenterol , vol.10 , pp. 1579-1584
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3
  • 9
    • 50649094716 scopus 로고    scopus 로고
    • Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study
    • Dunn W, Xu R, Wingard DL, et al. Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study. Am J Gastroenterol 2008 103 : 2263 2271.
    • (2008) Am J Gastroenterol , vol.103 , pp. 2263-2271
    • Dunn, W.1    Xu, R.2    Wingard, D.L.3
  • 10
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF. Steatohepatitis: a tale of two "hits"?. Gastroenterology 1998 114 : 842 845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 11
    • 36349024819 scopus 로고    scopus 로고
    • A lipidomic analysis of nonalcoholic fatty liver disease
    • Puri P, Baillie RA, Wiest MM, et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology 2007 46 : 1081 1090.
    • (2007) Hepatology , vol.46 , pp. 1081-1090
    • Puri, P.1    Baillie, R.A.2    Wiest, M.M.3
  • 13
    • 0032779351 scopus 로고    scopus 로고
    • Molecular mechanism of metabolic syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances
    • Matsuzawa Y, Funahashi T, Nakamura T. Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci 1999 892 : 892.
    • (1999) Ann N y Acad Sci , vol.892 , pp. 892
    • Matsuzawa, Y.1    Funahashi, T.2    Nakamura, T.3
  • 16
    • 13244295710 scopus 로고    scopus 로고
    • Plasma adiponectin is decreased in nonalcoholic fatty liver disease
    • Pagano C, Soardo G, Esposito W, et al. Plasma adiponectin is decreased in nonalcoholic fatty liver disease. Eur J Endocrinol 2005 152 : 113 118.
    • (2005) Eur J Endocrinol , vol.152 , pp. 113-118
    • Pagano, C.1    Soardo, G.2    Esposito, W.3
  • 17
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006 6 : 772 783.
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 18
    • 41349117261 scopus 로고    scopus 로고
    • Therapy for nonalcoholic fatty liver disease
    • Moseley RH. Therapy for nonalcoholic fatty liver disease. J Clin Gastroenterol 2008 42 : 332 335.
    • (2008) J Clin Gastroenterol , vol.42 , pp. 332-335
    • Moseley, R.H.1
  • 19
    • 34848830434 scopus 로고    scopus 로고
    • Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): A population based study
    • Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, et al. Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol 2007 47 : 711 717.
    • (2007) J Hepatol , vol.47 , pp. 711-717
    • Zelber-Sagi, S.1    Nitzan-Kaluski, D.2    Goldsmith, R.3
  • 20
    • 52949099824 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids: A specific liver drug for non-alcoholic fatty liver disease (NAFLD)
    • Xin YN, Xuan SY, Zhang JH, Zheng MH, Guan HS. Omega-3 polyunsaturated fatty acids: a specific liver drug for non-alcoholic fatty liver disease (NAFLD). Med Hypotheses 2008 71 : 820 821.
    • (2008) Med Hypotheses , vol.71 , pp. 820-821
    • Xin, Y.N.1    Xuan, S.Y.2    Zhang, J.H.3    Zheng, M.H.4    Guan, H.S.5
  • 21
    • 34247885908 scopus 로고    scopus 로고
    • Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia
    • DOI 10.1592/phco.27.5.715
    • McKenney JM, Sica D. Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. Pharmacotherapy 2007 27 : 715 728. (Pubitemid 46700964)
    • (2007) Pharmacotherapy , vol.27 , Issue.5 , pp. 715-728
    • McKenney, J.M.1    Sica, D.2
  • 22
    • 33747104166 scopus 로고    scopus 로고
    • Secondary prevention of coronary artery disease with omega-3 fatty acids
    • Jacobson TA. Secondary prevention of coronary artery disease with omega-3 fatty acids. Am J Cardiol 2006 98 (4A 6170.
    • (2006) Am J Cardiol , vol.98 , Issue.4 , pp. 6170
    • Jacobson, T.A.1
  • 23
    • 0033970890 scopus 로고    scopus 로고
    • N-3 fatty acids and the prevention of coronary atherosclerosis
    • von Schacky C. n-3 fatty acids and the prevention of coronary atherosclerosis. Am J Clin Nutr 2000 71 (1 Suppl. 224S 7S.
    • (2000) Am J Clin Nutr , vol.71 , Issue.1 SUPPL.
    • Von Schacky, C.1
  • 24
    • 67649804559 scopus 로고    scopus 로고
    • Anticancer actions of omega-3 fatty acids - Current state and future perspectives
    • Wendel M, Heller AR. Anticancer actions of omega-3 fatty acids - current state and future perspectives. Curr Med Chem Anticancer Agents 2009 9 : 457 470.
    • (2009) Curr Med Chem Anticancer Agents , vol.9 , pp. 457-470
    • Wendel, M.1    Heller, A.R.2
  • 25
    • 50149107932 scopus 로고    scopus 로고
    • Is there a role for n-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials
    • Appleton KM, Rogers PJ, Ness AR. Is there a role for n-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials. Nutr Res Rev 2008 21 : 13 41.
    • (2008) Nutr Res Rev , vol.21 , pp. 13-41
    • Appleton, K.M.1    Rogers, P.J.2    Ness, A.R.3
  • 26
    • 65249117459 scopus 로고    scopus 로고
    • Neurological benefits of omega-3 fatty acids
    • Dyall SC, Michael-Titus AT. Neurological benefits of omega-3 fatty acids. Neuromolecular Med 2008 10 : 219 235.
    • (2008) Neuromolecular Med , vol.10 , pp. 219-235
    • Dyall, S.C.1    Michael-Titus, A.T.2
  • 27
    • 0347319575 scopus 로고    scopus 로고
    • Immunomodulation by polyunsaturated fatty acids: Mechanisms and effects
    • Stulnig TM. Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. Int Arch Allergy Immunol 2003 132 : 310 321.
    • (2003) Int Arch Allergy Immunol , vol.132 , pp. 310-321
    • Stulnig, T.M.1
  • 28
    • 14244258691 scopus 로고    scopus 로고
    • Novel eicosanoid and docosanoid mediators: Resolvins, docosatrienes, and neuroprotectins
    • Serhan CN. Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. Curr Opin Clin Nutr Metab Care 2005 8 : 115 121.
    • (2005) Curr Opin Clin Nutr Metab Care , vol.8 , pp. 115-121
    • Serhan, C.N.1
  • 29
    • 34848880484 scopus 로고    scopus 로고
    • Omega 3 - Omega 6: What is right for the liver?
    • El-Badry AM, Graf R, Clavien PA. Omega 3 - Omega 6: what is right for the liver? J Hepatol 2007 47 : 718 725.
    • (2007) J Hepatol , vol.47 , pp. 718-725
    • El-Badry, A.M.1    Graf, R.2    Clavien, P.A.3
  • 30
    • 33846431254 scopus 로고    scopus 로고
    • Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: A study of human liver samples
    • Vuppalanchi R, Cummings OW, Saxena R, et al. Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples. J Clin Gastroenterol 2007 41 : 206 210.
    • (2007) J Clin Gastroenterol , vol.41 , pp. 206-210
    • Vuppalanchi, R.1    Cummings, O.W.2    Saxena, R.3
  • 31
    • 38149102572 scopus 로고    scopus 로고
    • How relevant is the ratio of dietary n-6 to n-3 polyunsaturated fatty acids to cardiovascular disease risk? Evidence from the OPTILIP study
    • Griffin BA. How relevant is the ratio of dietary n-6 to n-3 polyunsaturated fatty acids to cardiovascular disease risk? Evidence from the OPTILIP study. Curr Opin Lipidol 2008 19 : 57 62.
    • (2008) Curr Opin Lipidol , vol.19 , pp. 57-62
    • Griffin, B.A.1
  • 32
    • 5344239586 scopus 로고    scopus 로고
    • Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease
    • Videla LA, Rodrigo R, Araya J, Poniachik J. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. Free Radic Biol Med 2004 37 : 1499 1507.
    • (2004) Free Radic Biol Med , vol.37 , pp. 1499-1507
    • Videla, L.A.1    Rodrigo, R.2    Araya, J.3    Poniachik, J.4
  • 33
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • Araya J, Rodrigo R, Videla LA, et al. Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci 2004 106 : 635 643.
    • (2004) Clin Sci , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3
  • 34
    • 37849028864 scopus 로고    scopus 로고
    • Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study
    • Allard JP, Aghdassi E, Mohammed S, et al. Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study. J Hepatol 2008 48 : 300 307.
    • (2008) J Hepatol , vol.48 , pp. 300-307
    • Allard, J.P.1    Aghdassi, E.2    Mohammed, S.3
  • 35
    • 43249114663 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
    • Jump DB. N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr Opin Lipidol 2008 19 : 242 247.
    • (2008) Curr Opin Lipidol , vol.19 , pp. 242-247
    • Jump, D.B.1
  • 36
    • 2442711384 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and atherogenesis: Regulators of gene expression in vascular cells
    • Marx N, Duez H, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells. Circ Res 2004 94 : 1168 1178.
    • (2004) Circ Res , vol.94 , pp. 1168-1178
    • Marx, N.1    Duez, H.2    Fruchart, J.C.3    Staels, B.4
  • 37
    • 0033379344 scopus 로고    scopus 로고
    • Fibrates, dyslipoproteinaemia and cardiovascular disease
    • Watts GF, Dimmitt SB. Fibrates, dyslipoproteinaemia and cardiovascular disease. Curr Opin Lipidol 1999 10 : 561 574.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 561-574
    • Watts, G.F.1    Dimmitt, S.B.2
  • 39
    • 0038643427 scopus 로고    scopus 로고
    • Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice
    • Ip E, Farrell GC, Robertson G, Hall P, Kirsch R, Leclercq I. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology 2003 38 : 123 132.
    • (2003) Hepatology , vol.38 , pp. 123-132
    • Ip, E.1    Farrell, G.C.2    Robertson, G.3    Hall, P.4    Kirsch, R.5    Leclercq, I.6
  • 40
    • 2342644813 scopus 로고    scopus 로고
    • Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice
    • Ip E, Farrell G, Hall P, Robertson G, Leclercq I. Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice. Hepatology 2004 39 : 1286 1296.
    • (2004) Hepatology , vol.39 , pp. 1286-1296
    • Ip, E.1    Farrell, G.2    Hall, P.3    Robertson, G.4    Leclercq, I.5
  • 41
    • 0033105510 scopus 로고    scopus 로고
    • Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
    • Xu HE, Lambert MH, Montana VG, et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell 1999 3 : 397 403.
    • (1999) Mol Cell , vol.3 , pp. 397-403
    • Xu, H.E.1    Lambert, M.H.2    Montana, V.G.3
  • 42
    • 0141592581 scopus 로고    scopus 로고
    • Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes
    • Pawar A, Jump DB. Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes. J Biol Chem 2003 278 : 35931 35939.
    • (2003) J Biol Chem , vol.278 , pp. 35931-35939
    • Pawar, A.1    Jump, D.B.2
  • 43
    • 33645891166 scopus 로고    scopus 로고
    • Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet
    • Nagasawa T, Inada Y, Nakano S, et al. Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet. Eur J Pharmacol 2006 536 : 182 191.
    • (2006) Eur J Pharmacol , vol.536 , pp. 182-191
    • Nagasawa, T.1    Inada, Y.2    Nakano, S.3
  • 44
    • 33846623798 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
    • Brown JD, Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation 2007 115 : 518 533.
    • (2007) Circulation , vol.115 , pp. 518-533
    • Brown, J.D.1    Plutzky, J.2
  • 45
    • 34250821923 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation
    • Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S, Muller M. Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation. Endocrinology 2007 148 : 2753 2763.
    • (2007) Endocrinology , vol.148 , pp. 2753-2763
    • Stienstra, R.1    Mandard, S.2    Patsouris, D.3    Maass, C.4    Kersten, S.5    Muller, M.6
  • 46
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002 109 : 1125 1131.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 47
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
    • Foretz M, Guichard C, Ferre P, Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci U S A 1999 96 : 12737 12742.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3    Foufelle, F.4
  • 48
    • 0034283596 scopus 로고    scopus 로고
    • Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
    • Azzout-Marniche D, Becard D, Guichard C, Foretz M, Ferre P, Foufelle F. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem J 2000 350 : 389 393.
    • (2000) Biochem J , vol.350 , pp. 389-393
    • Azzout-Marniche, D.1    Becard, D.2    Guichard, C.3    Foretz, M.4    Ferre, P.5    Foufelle, F.6
  • 49
    • 30844437681 scopus 로고    scopus 로고
    • Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways
    • Botolin D, Wang Y, Christian B, Jump DB. Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. J Lipid Res 2006 47 : 181 192.
    • (2006) J Lipid Res , vol.47 , pp. 181-192
    • Botolin, D.1    Wang, Y.2    Christian, B.3    Jump, D.B.4
  • 50
    • 0030907175 scopus 로고    scopus 로고
    • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
    • Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 1997 99 : 846 854.
    • (1997) J Clin Invest , vol.99 , pp. 846-854
    • Shimano, H.1    Horton, J.D.2    Shimomura, I.3    Hammer, R.E.4    Brown, M.S.5    Goldstein, J.L.6
  • 51
    • 0033544869 scopus 로고    scopus 로고
    • A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
    • Yahagi N, Shimano H, Hasty AH, et al. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J Biol Chem 1999 274 : 35840 35844.
    • (1999) J Biol Chem , vol.274 , pp. 35840-35844
    • Yahagi, N.1    Shimano, H.2    Hasty, A.H.3
  • 52
    • 18544388579 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
    • Yoshikawa T, Shimano H, Yahagi N, et al. Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem 2002 277 : 1705 1711.
    • (2002) J Biol Chem , vol.277 , pp. 1705-1711
    • Yoshikawa, T.1    Shimano, H.2    Yahagi, N.3
  • 53
    • 0035971159 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay
    • Xu J, Teran-Garcia M, Park JH, Nakamura MT, Clarke SD. Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay. J Biol Chem 2001 276 : 9800 9807.
    • (2001) J Biol Chem , vol.276 , pp. 9800-9807
    • Xu, J.1    Teran-Garcia, M.2    Park, J.H.3    Nakamura, M.T.4    Clarke, S.D.5
  • 54
    • 0033551846 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
    • Xu J, Nakamura MT, Cho HP, Clarke SD. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem 1999 274 : 23577 23583.
    • (1999) J Biol Chem , vol.274 , pp. 23577-23583
    • Xu, J.1    Nakamura, M.T.2    Cho, H.P.3    Clarke, S.D.4
  • 55
    • 0032475841 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein
    • Worgall TS, Sturley SL, Seo T, Osborne TF, Deckelbaum RJ. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J Biol Chem 1998 273 : 25537 25540.
    • (1998) J Biol Chem , vol.273 , pp. 25537-25540
    • Worgall, T.S.1    Sturley, S.L.2    Seo, T.3    Osborne, T.F.4    Deckelbaum, R.J.5
  • 56
    • 0033520484 scopus 로고    scopus 로고
    • Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs
    • Kim HJ, Takahashi M, Ezaki O. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs. J Biol Chem 1999 274 : 25892 25898.
    • (1999) J Biol Chem , vol.274 , pp. 25892-25898
    • Kim, H.J.1    Takahashi, M.2    Ezaki, O.3
  • 57
    • 0029966268 scopus 로고    scopus 로고
    • Effects of fish oil on metabolic responses to oral fructose and glucose loads in healthy humans
    • Delarue J, Couet C, Cohen R, Brechot JF, Antoine JM, Lamisse F. Effects of fish oil on metabolic responses to oral fructose and glucose loads in healthy humans. Am J Physiol 1996 270 : E353 62.
    • (1996) Am J Physiol , vol.270 , pp. 353-62
    • Delarue, J.1    Couet, C.2    Cohen, R.3    Brechot, J.F.4    Antoine, J.M.5    Lamisse, F.6
  • 58
    • 0041419336 scopus 로고    scopus 로고
    • Diabetogenic impact of long-chain omega-3 fatty acids on pancreatic beta-cell function and the regulation of endogenous glucose production
    • Holness MJ, Greenwood GK, Smith ND, Sugden MC. Diabetogenic impact of long-chain omega-3 fatty acids on pancreatic beta-cell function and the regulation of endogenous glucose production. Endocrinology 2003 144 : 3958 3968.
    • (2003) Endocrinology , vol.144 , pp. 3958-3968
    • Holness, M.J.1    Greenwood, G.K.2    Smith, N.D.3    Sugden, M.C.4
  • 59
    • 23944435868 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation of genes of lipid metabolism
    • Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr 2005 25 : 317 340.
    • (2005) Annu Rev Nutr , vol.25 , pp. 317-340
    • Sampath, H.1    Ntambi, J.M.2
  • 60
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • Repa JJ, Mangelsdorf DJ. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 2000 16 : 459 481.
    • (2000) Annu Rev Cell Dev Biol , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 61
    • 0142103471 scopus 로고    scopus 로고
    • The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression
    • Pawar A, Botolin D, Mangelsdorf DJ, Jump DB. The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. J Biol Chem 2003 278 : 40736 40743.
    • (2003) J Biol Chem , vol.278 , pp. 40736-40743
    • Pawar, A.1    Botolin, D.2    Mangelsdorf, D.J.3    Jump, D.B.4
  • 62
    • 0036646116 scopus 로고    scopus 로고
    • Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes
    • Roth U, Jungermann K, Kietzmann T. Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes. Biochem J 2002 365 : 223 228.
    • (2002) Biochem J , vol.365 , pp. 223-228
    • Roth, U.1    Jungermann, K.2    Kietzmann, T.3
  • 63
    • 85047694456 scopus 로고    scopus 로고
    • Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    • Watanabe M, Houten SM, Wang L, et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004 113 : 1408 1418.
    • (2004) J Clin Invest , vol.113 , pp. 1408-1418
    • Watanabe, M.1    Houten, S.M.2    Wang, L.3
  • 64
    • 33747128489 scopus 로고    scopus 로고
    • Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids.[see comment]
    • Davidson MH. Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids.[see comment]. Am J Cardiol 2006 98 (4A 2733.
    • (2006) Am J Cardiol , vol.98 , Issue.4 , pp. 2733
    • Davidson, M.H.1
  • 65
    • 26444434340 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
    • Dentin R, Benhamed F, Pegorier JP, et al. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest 2005 115 : 2843 2854.
    • (2005) J Clin Invest , vol.115 , pp. 2843-2854
    • Dentin, R.1    Benhamed, F.2    Pegorier, J.P.3
  • 66
    • 33745856925 scopus 로고    scopus 로고
    • Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist
    • Xu J, Christian B, Jump DB. Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem 2006 281 : 18351 18362.
    • (2006) J Biol Chem , vol.281 , pp. 18351-18362
    • Xu, J.1    Christian, B.2    Jump, D.B.3
  • 67
    • 33749370739 scopus 로고    scopus 로고
    • Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
    • Dentin R, Benhamed F, Hainault I, et al. Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes 2006 55 : 2159 2170.
    • (2006) Diabetes , vol.55 , pp. 2159-2170
    • Dentin, R.1    Benhamed, F.2    Hainault, I.3
  • 68
    • 0030783119 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha
    • Ren B, Thelen AP, Peters JM, Gonzalez FJ, Jump DB. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha. J Biol Chem 1997 272 : 26827 26832.
    • (1997) J Biol Chem , vol.272 , pp. 26827-26832
    • Ren, B.1    Thelen, A.P.2    Peters, J.M.3    Gonzalez, F.J.4    Jump, D.B.5
  • 69
    • 0033565968 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids inhibit fatty acid synthase and spot-14-protein gene expression in cultured rat hepatocytes by a peroxidative mechanism
    • Foretz M, Foufelle F, Ferre P. Polyunsaturated fatty acids inhibit fatty acid synthase and spot-14-protein gene expression in cultured rat hepatocytes by a peroxidative mechanism. Biochem J 1999 341 : 371 376.
    • (1999) Biochem J , vol.341 , pp. 371-376
    • Foretz, M.1    Foufelle, F.2    Ferre, P.3
  • 70
    • 5344268800 scopus 로고    scopus 로고
    • Omega-3 fatty acids in cellular membranes: A unified concept
    • Valentine RC, Valentine DL. Omega-3 fatty acids in cellular membranes: a unified concept. Prog Lipid Res 2004 43 : 383 402.
    • (2004) Prog Lipid Res , vol.43 , pp. 383-402
    • Valentine, R.C.1    Valentine, D.L.2
  • 71
    • 0031052912 scopus 로고    scopus 로고
    • The influence of dietary lipids on the composition and membrane fluidity of rat hepatocyte plasma membrane
    • Clamp AG, Ladha S, Clark DC, Grimble RF, Lund EK. The influence of dietary lipids on the composition and membrane fluidity of rat hepatocyte plasma membrane. Lipids 1997 32 : 179 184.
    • (1997) Lipids , vol.32 , pp. 179-184
    • Clamp, A.G.1    Ladha, S.2    Clark, D.C.3    Grimble, R.F.4    Lund, E.K.5
  • 72
    • 0027395358 scopus 로고
    • The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids
    • Borkman M, Storlien LH, Pan DA, Jenkins AB, Chisholm DJ, Campbell LV. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med 1993 328 : 238 244.
    • (1993) N Engl J Med , vol.328 , pp. 238-244
    • Borkman, M.1    Storlien, L.H.2    Pan, D.A.3    Jenkins, A.B.4    Chisholm, D.J.5    Campbell, L.V.6
  • 73
    • 0033860284 scopus 로고    scopus 로고
    • Fish oil modulates macrophage P44/P42 mitogen-activated protein kinase activity induced by lipopolysaccharide
    • Lo CJ, Chiu KC, Fu M, Chu A, Helton S. Fish oil modulates macrophage P44/P42 mitogen-activated protein kinase activity induced by lipopolysaccharide. JPEN J Parenter Enteral Nutr 2000 24 : 159 163.
    • (2000) JPEN J Parenter Enteral Nutr , vol.24 , pp. 159-163
    • Lo, C.J.1    Chiu, K.C.2    Fu, M.3    Chu, A.4    Helton, S.5
  • 74
    • 25844480615 scopus 로고    scopus 로고
    • Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes
    • Guo W, Xie W, Lei T, Hamilton JA. Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes. Lipids 2005 40 : 815 821.
    • (2005) Lipids , vol.40 , pp. 815-821
    • Guo, W.1    Xie, W.2    Lei, T.3    Hamilton, J.A.4
  • 75
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: Getting both pathology and metabolic context right
    • Larter CZ, Yeh MM. Animal models of NASH: getting both pathology and metabolic context right. J Gastroenterol Hepatol 2008 23 : 1635 1648.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 76
    • 59349092761 scopus 로고    scopus 로고
    • Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice
    • Ishii H, Horie Y, Ohshima S, et al. Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J Hepatol 2009 50 : 562 571.
    • (2009) J Hepatol , vol.50 , pp. 562-571
    • Ishii, H.1    Horie, Y.2    Ohshima, S.3
  • 77
    • 34548274430 scopus 로고    scopus 로고
    • Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects
    • Itoh M, Suganami T, Satoh N, et al. Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler Thromb Vasc Biol 2007 27 : 1918 1925.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1918-1925
    • Itoh, M.1    Suganami, T.2    Satoh, N.3
  • 78
    • 34249889960 scopus 로고    scopus 로고
    • Metabolic syndrome: Effects of n-3 PUFAs on a model of dyslipidemia, insulin resistance and adiposity
    • Lombardo YB, Hein G, Chicco A. Metabolic syndrome: effects of n-3 PUFAs on a model of dyslipidemia, insulin resistance and adiposity. Lipids 2007 42 : 427 437.
    • (2007) Lipids , vol.42 , pp. 427-437
    • Lombardo, Y.B.1    Hein, G.2    Chicco, A.3
  • 80
    • 14944342635 scopus 로고    scopus 로고
    • Omega-3 fatty acids improve hepatic steatosis in a murine model: Potential implications for the marginal steatotic liver donor
    • Alwayn IP, Andersson C, Zauscher B, Gura K, Nose V, Puder M. Omega-3 fatty acids improve hepatic steatosis in a murine model: potential implications for the marginal steatotic liver donor. Transplantation 2005 79 : 606 608.
    • (2005) Transplantation , vol.79 , pp. 606-608
    • Alwayn, I.P.1    Andersson, C.2    Zauscher, B.3    Gura, K.4    Nose, V.5    Puder, M.6
  • 81
    • 67349249102 scopus 로고    scopus 로고
    • Highly purified eicosapentaenoic acid prevents the progression of hepatic steatosis by repressing monounsaturated fatty acid synthesis in high-fat/high-sucrose diet-fed mice
    • Kajikawa S, Harada T, Kawashima A, Imada K, Mizuguchi K. Highly purified eicosapentaenoic acid prevents the progression of hepatic steatosis by repressing monounsaturated fatty acid synthesis in high-fat/high-sucrose diet-fed mice. Prostaglandins Leukot Essent Fatty Acids 2009 80 : 229 238.
    • (2009) Prostaglandins Leukot Essent Fatty Acids , vol.80 , pp. 229-238
    • Kajikawa, S.1    Harada, T.2    Kawashima, A.3    Imada, K.4    Mizuguchi, K.5
  • 82
    • 67649363782 scopus 로고    scopus 로고
    • Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: A role for resolvins and protectins
    • Gonzalez-Periz A, Horrillo R, Ferre N, et al. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J 2009 23 : 1946 1957.
    • (2009) FASEB J , vol.23 , pp. 1946-1957
    • Gonzalez-Periz, A.1    Horrillo, R.2    Ferre, N.3
  • 83
    • 0345448923 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
    • Sekiya M, Yahagi N, Matsuzaka T, et al. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology 2003 38 : 1529 1539.
    • (2003) Hepatology , vol.38 , pp. 1529-1539
    • Sekiya, M.1    Yahagi, N.2    Matsuzaka, T.3
  • 84
    • 33748794808 scopus 로고    scopus 로고
    • A model of insulin resistance and nonalcoholic steatohepatitis in rats: Role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury
    • Svegliati-Baroni G, Candelaresi C, Saccomanno S, et al. A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol 2006 169 : 846 860.
    • (2006) Am J Pathol , vol.169 , pp. 846-860
    • Svegliati-Baroni, G.1    Candelaresi, C.2    Saccomanno, S.3
  • 85
    • 54549120218 scopus 로고    scopus 로고
    • Dietary docosahexaenoic acid-rich diacylglycerols ameliorate hepatic steatosis and alter hepatic gene expressions in C57BL/6J-Lep(ob/ob) mice
    • Kim HJ, Lee KT, Park YB, Jeon SM, Choi MS. Dietary docosahexaenoic acid-rich diacylglycerols ameliorate hepatic steatosis and alter hepatic gene expressions in C57BL/6J-Lep(ob/ob) mice. Mol Nutr Food Res 2008 52 : 965 973.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 965-973
    • Kim, H.J.1    Lee, K.T.2    Park, Y.B.3    Jeon, S.M.4    Choi, M.S.5
  • 86
    • 39149132072 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation
    • Larter CZ, Yeh MM, Cheng J, et al. Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. J Gastroenterol Hepatol 2008 23 : 267 275.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 267-275
    • Larter, C.Z.1    Yeh, M.M.2    Cheng, J.3
  • 87
    • 1542410333 scopus 로고    scopus 로고
    • Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats
    • Levy JR, Clore JN, Stevens W. Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats. Hepatology 2004 39 : 608 616.
    • (2004) Hepatology , vol.39 , pp. 608-616
    • Levy, J.R.1    Clore, J.N.2    Stevens, W.3
  • 88
    • 33646173466 scopus 로고    scopus 로고
    • Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease
    • Oliveira CP, Coelho AM, Barbeiro HV, et al. Liver mitochondrial dysfunction and oxidative stress in the pathogenesis of experimental nonalcoholic fatty liver disease. Braz J Med Biol Res 2006 39 : 189 194.
    • (2006) Braz J Med Biol Res , vol.39 , pp. 189-194
    • Oliveira, C.P.1    Coelho, A.M.2    Barbeiro, H.V.3
  • 89
    • 0034711185 scopus 로고    scopus 로고
    • Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators
    • Delerive P, Gervois P, Fruchart JC, Staels B. Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem 2000 275 : 36703 36707.
    • (2000) J Biol Chem , vol.275 , pp. 36703-36707
    • Delerive, P.1    Gervois, P.2    Fruchart, J.C.3    Staels, B.4
  • 90
    • 0036137817 scopus 로고    scopus 로고
    • Total fat and (n-3):(n-6) fat ratios influence eicosanoid production in mice
    • Broughton KS, Wade JW. Total fat and (n-3):(n-6) fat ratios influence eicosanoid production in mice. J Nutr 2002 132 : 88 94.
    • (2002) J Nutr , vol.132 , pp. 88-94
    • Broughton, K.S.1    Wade, J.W.2
  • 91
    • 0033665278 scopus 로고    scopus 로고
    • Eicosapentaenoic acid (EPA): An antiinflammatory omega-3 fat with potential clinical applications
    • Babcock T, Helton WS, Espat NJ. Eicosapentaenoic acid (EPA): an antiinflammatory omega-3 fat with potential clinical applications. Nutrition 2000 16 : 1116 1118.
    • (2000) Nutrition , vol.16 , pp. 1116-1118
    • Babcock, T.1    Helton, W.S.2    Espat, N.J.3
  • 92
    • 0029026467 scopus 로고
    • Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages
    • Yaqoob P, Calder P. Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages. Cell Immunol 1995 163 : 120 128.
    • (1995) Cell Immunol , vol.163 , pp. 120-128
    • Yaqoob, P.1    Calder, P.2
  • 93
    • 31844451413 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet
    • Flachs P, Mohamed-Ali V, Horakova O, et al. Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia 2006 49 : 394 397.
    • (2006) Diabetologia , vol.49 , pp. 394-397
    • Flachs, P.1    Mohamed-Ali, V.2    Horakova, O.3
  • 94
    • 33646882162 scopus 로고    scopus 로고
    • Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: A pilot study
    • Capanni M, Calella F, Biagini MR, et al. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharmacol Ther 2006 23 : 1143 1151.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1143-1151
    • Capanni, M.1    Calella, F.2    Biagini, M.R.3
  • 95
    • 38749115791 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease
    • Spadaro L, Magliocco O, Spampinato D, et al. Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. Dig Liver Dis 2008 40 : 194 199.
    • (2008) Dig Liver Dis , vol.40 , pp. 194-199
    • Spadaro, L.1    Magliocco, O.2    Spampinato, D.3
  • 97
    • 0037232972 scopus 로고    scopus 로고
    • Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease
    • Sumida Y, Nakashima T, Yoh T, et al. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J Hepatol 2003 38 : 32 8.
    • (2003) J Hepatol , vol.38 , pp. 32-8
    • Sumida, Y.1    Nakashima, T.2    Yoh, T.3
  • 98
    • 49149084590 scopus 로고    scopus 로고
    • Effects of N-3 fatty acids on hepatic triglyceride content in humans
    • Vega GL, Chandalia M, Szczepaniak LS, Grundy SM. Effects of N-3 fatty acids on hepatic triglyceride content in humans. J Invest Med 2008 56 : 780 785.
    • (2008) J Invest Med , vol.56 , pp. 780-785
    • Vega, G.L.1    Chandalia, M.2    Szczepaniak, L.S.3    Grundy, S.M.4
  • 99
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004 40 : 1387 1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 100
    • 34547732002 scopus 로고    scopus 로고
    • GI epidemiology: Nonalcoholic fatty liver disease
    • Angulo P. GI epidemiology: nonalcoholic fatty liver disease. Aliment Pharmacol Ther 2007 25 : 883 889.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 883-889
    • Angulo, P.1
  • 101
    • 0043268063 scopus 로고    scopus 로고
    • Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
    • Hui JM, Kench JG, Chitturi S, et al. Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. Hepatology 2003 38 : 420 427.
    • (2003) Hepatology , vol.38 , pp. 420-427
    • Hui, J.M.1    Kench, J.G.2    Chitturi, S.3
  • 102
    • 19144372447 scopus 로고    scopus 로고
    • One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: A pilot study
    • Huang MA, Greenson JK, Chao C, et al. One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study. Am J Gastroenterol 2005 100 : 1072 1081.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1072-1081
    • Huang, M.A.1    Greenson, J.K.2    Chao, C.3
  • 103
    • 1242340436 scopus 로고    scopus 로고
    • Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life
    • Hickman IJ, Jonsson JR, Prins JB, et al. Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut 2004 53 : 413 419.
    • (2004) Gut , vol.53 , pp. 413-419
    • Hickman, I.J.1    Jonsson, J.R.2    Prins, J.B.3
  • 104
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010 51 : 121 129.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 106
    • 58949102847 scopus 로고    scopus 로고
    • Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial
    • Harrison SA, Fecht W, Brunt EM, Neuschwander-Tetri BA. Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial. Hepatology 2009 49 : 80 6.
    • (2009) Hepatology , vol.49 , pp. 80-6
    • Harrison, S.A.1    Fecht, W.2    Brunt, E.M.3    Neuschwander-Tetri, B.A.4
  • 107
    • 0141515773 scopus 로고    scopus 로고
    • The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis
    • Sabuncu T, Nazligul Y, Karaoglanoglu M, Ucar E, Kilic FB. The effects of sibutramine and orlistat on the ultrasonographic findings, insulin resistance and liver enzyme levels in obese patients with non-alcoholic steatohepatitis. Rom J Gastroenterol 2003 12 : 189 192.
    • (2003) Rom J Gastroenterol , vol.12 , pp. 189-192
    • Sabuncu, T.1    Nazligul, Y.2    Karaoglanoglu, M.3    Ucar, E.4    Kilic, F.B.5
  • 108
    • 34548642096 scopus 로고    scopus 로고
    • Rimonabant as a novel therapeutic option for nonalcoholic steatohepatitis
    • Banasch M, Goetze O, Schmidt WE, Meier JJ. Rimonabant as a novel therapeutic option for nonalcoholic steatohepatitis. Liver Int 2007 27 : 1152 1155.
    • (2007) Liver Int , vol.27 , pp. 1152-1155
    • Banasch, M.1    Goetze, O.2    Schmidt, W.E.3    Meier, J.J.4
  • 109
    • 2542546652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
    • Dixon JB, Bhathal PS, Hughes NR, O'Brien PE. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology 2004 39 : 1647 1654.
    • (2004) Hepatology , vol.39 , pp. 1647-1654
    • Dixon, J.B.1    Bhathal, P.S.2    Hughes, N.R.3    O'Brien, P.E.4
  • 110
    • 34249791215 scopus 로고    scopus 로고
    • Resolution of nonalcoholic steatohepatits after gastric bypass surgery
    • Liu X, Lazenby AJ, Clements RH, Jhala N, Abrams GA. Resolution of nonalcoholic steatohepatits after gastric bypass surgery. Obesity Surg 2007 17 : 486 492.
    • (2007) Obesity Surg , vol.17 , pp. 486-492
    • Liu, X.1    Lazenby, A.J.2    Clements, R.H.3    Jhala, N.4    Abrams, G.A.5
  • 111
    • 57149101692 scopus 로고    scopus 로고
    • Effect of bariatric surgery on nonalcoholic fatty liver disease: Systematic review and meta-analysis
    • Mummadi RR, Kasturi KS, Chennareddygari S, Sood GK. Effect of bariatric surgery on nonalcoholic fatty liver disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol 2008 6 : 1396 1402.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1396-1402
    • Mummadi, R.R.1    Kasturi, K.S.2    Chennareddygari, S.3    Sood, G.K.4
  • 112
    • 33947247615 scopus 로고    scopus 로고
    • Effects of bariatric surgery on nonalcoholic fatty liver disease: Preliminary findings after 2 years
    • Furuya CK Jr., de Oliveira CP, de Mello ES, et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastroenterol Hepatol 2007 22 : 510 514.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 510-514
    • Furuya, Jr.C.K.1    De Oliveira, C.P.2    De Mello, E.S.3
  • 114
    • 16444378976 scopus 로고    scopus 로고
    • A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis
    • Schwimmer JB, Middleton MS, Deutsch R, Lavine JE. A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2005 21 : 871 879.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 871-879
    • Schwimmer, J.B.1    Middleton, M.S.2    Deutsch, R.3    Lavine, J.E.4
  • 115
    • 47149111845 scopus 로고    scopus 로고
    • Metformin use in children with nonalcoholic fatty liver disease: An open-label, 24-month, observational pilot study
    • Nobili V, Manco M, Ciampalini P, et al. Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study. Clin Ther 2008 30 : 1168 1176.
    • (2008) Clin Ther , vol.30 , pp. 1168-1176
    • Nobili, V.1    Manco, M.2    Ciampalini, P.3
  • 116
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin e or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E, Gentilcore E, Manini R, et al. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol 2005 100 : 1082 1090.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3
  • 117
    • 57649229536 scopus 로고    scopus 로고
    • Clinical trial: Pilot study of metformin for the treatment of nonalcoholic steatohepatitis
    • Loomba R, Lutchman G, Kleiner DE, et al. Clinical trial: pilot study of metformin for the treatment of nonalcoholic steatohepatitis. Aliment Pharmacol Ther 2008 29 : 172 182.
    • (2008) Aliment Pharmacol Ther , vol.29 , pp. 172-182
    • Loomba, R.1    Lutchman, G.2    Kleiner, D.E.3
  • 119
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Oliver D, Bacon BR. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 2003 38 : 1008 1017.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 120
    • 1442355447 scopus 로고    scopus 로고
    • A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
    • Promrat K, Lutchman G, Uwaifo GI, et al. A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology 2004 39 : 188 196.
    • (2004) Hepatology , vol.39 , pp. 188-196
    • Promrat, K.1    Lutchman, G.2    Uwaifo, G.I.3
  • 121
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu V, Giral P, Jacqueminet S, et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 2008 135 : 100 110.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3
  • 122
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006 355 : 2297 2307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3
  • 123
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: A pilot study
    • Hasegawa T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther 2001 15 : 1667 1672.
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3    Makino, I.4    Terano, A.5
  • 124
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin e and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2003 98 : 2485 2490.
    • (2003) Am J Gastroenterol , vol.98 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3    Ward, J.4    Schenker, S.5
  • 125
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin e
    • Kugelmas M, Hill DB, Vivian B, Marsano L, McClain CJ. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 2003 38 : 413 419.
    • (2003) Hepatology , vol.38 , pp. 413-419
    • Kugelmas, M.1    Hill, D.B.2    Vivian, B.3    Marsano, L.4    McClain, C.J.5
  • 127
    • 7044269614 scopus 로고    scopus 로고
    • Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis
    • Satapathy SK, Garg S, Chauhan R, et al. Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2004 99 : 1946 1952.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1946-1952
    • Satapathy, S.K.1    Garg, S.2    Chauhan, R.3
  • 128
    • 11144249271 scopus 로고    scopus 로고
    • A pilot trial of pentoxifylline in nonalcoholic steatohepatitis
    • Adams LA, Zein CO, Angulo P, Lindor KD. A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. Am J Gastroenterol 2004 99 : 2365 2368.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2365-2368
    • Adams, L.A.1    Zein, C.O.2    Angulo, P.3    Lindor, K.D.4
  • 129
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
    • Lindor KD, Kowdley KV, Heathcote EJ, et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial. Hepatology 2004 39 : 770 778.
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1    Kowdley, K.V.2    Heathcote, E.J.3
  • 130
    • 7044222556 scopus 로고    scopus 로고
    • Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis
    • Yokohama S, Yoneda M, Haneda M, et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology 2004 40 : 1222 1225.
    • (2004) Hepatology , vol.40 , pp. 1222-1225
    • Yokohama, S.1    Yoneda, M.2    Haneda, M.3
  • 131
    • 65649112801 scopus 로고    scopus 로고
    • Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis
    • Georgescu EF, Ionescu R, Niculescu M, Mogoanta L, Vancica L. Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis. World J Gastroenterol 2009 15 : 942 954.
    • (2009) World J Gastroenterol , vol.15 , pp. 942-954
    • Georgescu, E.F.1    Ionescu, R.2    Niculescu, M.3    Mogoanta, L.4    Vancica, L.5
  • 132
    • 0034834208 scopus 로고    scopus 로고
    • Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: Results of a pilot study
    • Abdelmalek MF, Angulo P, Jorgensen RA, Sylvestre PB, Lindor KD. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001 96 : 2711 2717.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2711-2717
    • Abdelmalek, M.F.1    Angulo, P.2    Jorgensen, R.A.3    Sylvestre, P.B.4    Lindor, K.D.5
  • 133
    • 0242487635 scopus 로고    scopus 로고
    • N-acetylcysteine in the treatment of non-alcoholic steatohepatitis
    • Pamuk GE, Sonsuz A. N-acetylcysteine in the treatment of non-alcoholic steatohepatitis. J Gastroenterol Hepatol 2003 18 : 1220 1221.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1220-1221
    • Pamuk, G.E.1    Sonsuz, A.2
  • 134
    • 33748435506 scopus 로고    scopus 로고
    • Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis (NASH): A randomized pilot study
    • Chande N, Laidlaw M, Adams P, Marotta P. Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis (NASH): a randomized pilot study. Dig Dis Sci 2006 51 : 1183 1189.
    • (2006) Dig Dis Sci , vol.51 , pp. 1183-1189
    • Chande, N.1    Laidlaw, M.2    Adams, P.3    Marotta, P.4


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