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Volumn , Issue , 2009, Pages 36-63

Biology of Hematopoietic Stem and Progenitor Cells

Author keywords

Alternative developmental pathways; Biology of hematopoietic stem and progenitor cells; CLP cells and lymphoid development; Gene expression profile of stem and progenitor cells; Genetic pathways for self renewal of HSCs; History of HSC isolation; Lineage committed hematopoietic progenitor cells; LSC marker identification crucial to effective treatment strategies; Migration of HSCs; Ontogeny and aging of HSCs

Indexed keywords


EID: 84890784311     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444303537.ch5     Document Type: Chapter
Times cited : (5)

References (417)
  • 1
    • 0034614576 scopus 로고    scopus 로고
    • Stem cells: units of development, units of regeneration, and units in evolution
    • Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell, 2000; 100: 157-68.
    • (2000) Cell , vol.100 , pp. 157-168
    • Weissman, I.L.1
  • 2
    • 0000062301 scopus 로고
    • Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells
    • Becker AJ, Mc CE, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963; 197: 452-4.
    • (1963) Nature , vol.197 , pp. 452-454
    • Becker, A.J.1    Mc, C.E.2    Till, J.E.3
  • 4
    • 0025903359 scopus 로고
    • Clonal analysis of hematopoietic stem-cell differentiation in vivo
    • Smith LG, Weissman IL, Heimfeld S. Clonal analysis of hematopoietic stem-cell differentiation in vivo. Proc Natl Acad Sci U S A 1991; 88: 2788-92.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2788-2792
    • Smith, L.G.1    Weissman, I.L.2    Heimfeld, S.3
  • 5
    • 0037183884 scopus 로고    scopus 로고
    • Little evidence for developmental plasticity of adult hematopoietic stem cells
    • Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002; 297: 2256-9.
    • (2002) Science , vol.297 , pp. 2256-2259
    • Wagers, A.J.1    Sherwood, R.I.2    Christensen, J.L.3    Weissman, I.L.4
  • 6
    • 0024160887 scopus 로고
    • The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets
    • Spangrude GJ, Aihara Y, Weissman IL, Klein J. The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets. J Immunol 1988; 141: 3697-707.
    • (1988) J Immunol , vol.141 , pp. 3697-3707
    • Spangrude, G.J.1    Aihara, Y.2    Weissman, I.L.3    Klein, J.4
  • 8
    • 0029796633 scopus 로고    scopus 로고
    • Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
    • Osawa M, Hanada K, Hamada H, Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996; 273: 242-5.
    • (1996) Science , vol.273 , pp. 242-245
    • Osawa, M.1    Hanada, K.2    Hamada, H.3    Nakauchi, H.4
  • 9
    • 0022474392 scopus 로고
    • Developmental potential and dynamic behavior of hematopoietic stem cells
    • Lemischka IR, Raulet DH, Mulligan RC. Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 1986; 45: 917-27.
    • (1986) Cell , vol.45 , pp. 917-927
    • Lemischka, I.R.1    Raulet, D.H.2    Mulligan, R.C.3
  • 10
    • 0017647002 scopus 로고
    • The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems
    • Abramson S, Miller RG, Phillips RA. The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J Exp Med 1977; 145: 1567-79.
    • (1977) J Exp Med , vol.145 , pp. 1567-1579
    • Abramson, S.1    Miller, R.G.2    Phillips, R.A.3
  • 11
    • 0000165979 scopus 로고
    • Spleencolony formation in anemic mice of genotype Ww
    • McCulloch EA, Siminovitch L, Till JE. Spleencolony formation in anemic mice of genotype Ww. Science 1964; 144: 844-6.
    • (1964) Science , vol.144 , pp. 844-846
    • McCulloch, E.A.1    Siminovitch, L.2    Till, J.E.3
  • 12
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till JE, McCulloch EA. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 1961; 14: 213-22.
    • (1961) Radiat Res , vol.14 , pp. 213-222
    • Till, J.E.1    McCulloch, E.A.2
  • 13
    • 0000461656 scopus 로고
    • The distribution of colony-forming cells among spleen colonies
    • Siminovitch L, McCulloch EA, Till JE. The distribution of colony-forming cells among spleen colonies. J Cell Physiol 1963; 62: 327-36.
    • (1963) J Cell Physiol , vol.62 , pp. 327-336
    • Siminovitch, L.1    McCulloch, E.A.2    Till, J.E.3
  • 14
    • 0035182533 scopus 로고    scopus 로고
    • Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations
    • Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 2001; 17: 387-403.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 387-403
    • Weissman, I.L.1    Anderson, D.J.2    Gage, F.3
  • 15
    • 0035044318 scopus 로고    scopus 로고
    • Can stem cells cross lineage boundaries?
    • Anderson DJ, Gage FH, Weissman IL. Can stem cells cross lineage boundaries? Nat Med 2001; 7: 393-5.
    • (2001) Nat Med , vol.7 , pp. 393-395
    • Anderson, D.J.1    Gage, F.H.2    Weissman, I.L.3
  • 17
    • 0034712022 scopus 로고    scopus 로고
    • Translating stem and progenitor cell biology to the clinic: barriers and opportunities
    • Weissman IL. Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science 2000; 287: 1442-6.
    • (2000) Science , vol.287 , pp. 1442-1446
    • Weissman, I.L.1
  • 18
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y, Jahagirdar BN, Reinhardt RL et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41-9.
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 19
    • 0033525587 scopus 로고    scopus 로고
    • Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells
    • Morrison SJ, White PM, Zock C, Anderson DJ. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells. Cell 1999; 96: 737-49.
    • (1999) Cell , vol.96 , pp. 737-749
    • Morrison, S.J.1    White, P.M.2    Zock, C.3    Anderson, D.J.4
  • 20
    • 0030438734 scopus 로고    scopus 로고
    • The adult rat hippocampus contains primordial neural stem cells
    • Palmer TD, Takahashi J, Gage FH. The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 1997; 8: 389-404.
    • (1997) Mol Cell Neurosci , vol.8 , pp. 389-404
    • Palmer, T.D.1    Takahashi, J.2    Gage, F.H.3
  • 21
    • 0026535505 scopus 로고
    • Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
    • Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992; 255: 1707-10.
    • (1992) Science , vol.255 , pp. 1707-1710
    • Reynolds, B.A.1    Weiss, S.2
  • 22
    • 0026497015 scopus 로고
    • Isolation of a stem cell for neurons and glia from the mammalian neural crest
    • Stemple DL, Anderson DJ. Isolation of a stem cell for neurons and glia from the mammalian neural crest. Cell 1992; 71: 973-85.
    • (1992) Cell , vol.71 , pp. 973-985
    • Stemple, D.L.1    Anderson, D.J.2
  • 23
    • 0029967893 scopus 로고    scopus 로고
    • Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo
    • Suhonen JO, Peterson DA, Ray J, Gage FH. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature 1996; 383: 624-7.
    • (1996) Nature , vol.383 , pp. 624-627
    • Suhonen, J.O.1    Peterson, D.A.2    Ray, J.3    Gage, F.H.4
  • 24
    • 0034682742 scopus 로고    scopus 로고
    • Involvement of follicular stem cells in forming not only the follicle but also the epidermis
    • Taylor G, Lehrer MS, Jensen PJ, Sun TT, Lavker RM. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 2000; 102: 451-61.
    • (2000) Cell , vol.102 , pp. 451-461
    • Taylor, G.1    Lehrer, M.S.2    Jensen, P.J.3    Sun, T.T.4    Lavker, R.M.5
  • 25
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 1997; 91: 661-72.
    • (1997) Cell , vol.91 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 26
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000; 404: 193-7.
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 27
    • 0345636016 scopus 로고    scopus 로고
    • Effect of TERT overexpression on the long-term transplantation capacity of hematopoietic stem cells
    • Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL. Effect of TERT overexpression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med 2003; 9: 369-71.
    • (2003) Nat Med , vol.9 , pp. 369-371
    • Allsopp, R.C.1    Morin, G.B.2    Horner, J.W.3    DePinho, R.4    Harley, C.B.5    Weissman, I.L.6
  • 28
    • 0000448725 scopus 로고
    • Modification of irradiation injury in mice and guinea pigs by bone marrow injections
    • Lorenz E, Uphoff D, Reid TR, Shelton E. Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst 1951; 12: 197-201.
    • (1951) J Natl Cancer Inst , vol.12 , pp. 197-201
    • Lorenz, E.1    Uphoff, D.2    Reid, T.R.3    Shelton, E.4
  • 33
    • 0000838940 scopus 로고
    • Growth and continued function of rat marrow cells in x-radiated mice
    • Nowell PC, Cole LJ, Habermeyer JG, Roan PL. Growth and continued function of rat marrow cells in x-radiated mice. Cancer Res 1956; 16: 258-61.
    • (1956) Cancer Res , vol.16 , pp. 258-261
    • Nowell, P.C.1    Cole, L.J.2    Habermeyer, J.G.3    Roan, P.L.4
  • 34
    • 0014261595 scopus 로고
    • Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system
    • Wu AM, Till JE, Siminovitch L, McCulloch EA. Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system. J Exp Med 1968; 127: 455-64.
    • (1968) J Exp Med , vol.127 , pp. 455-464
    • Wu, A.M.1    Till, J.E.2    Siminovitch, L.3    McCulloch, E.A.4
  • 35
    • 0020052387 scopus 로고
    • Transient nature of early haematopoietic spleen colonies
    • Magli MC, Iscove NN, Odartchenko N. Transient nature of early haematopoietic spleen colonies. Nature 1982; 295: 527-9.
    • (1982) Nature , vol.295 , pp. 527-529
    • Magli, M.C.1    Iscove, N.N.2    Odartchenko, N.3
  • 36
    • 0025346951 scopus 로고
    • Purification of pluripotent hemopoietic stem cells: past and present
    • Visser JW, Van Bekkum DW. Purification of pluripotent hemopoietic stem cells: past and present. Exp Hematol 1990; 18: 248-56.
    • (1990) Exp Hematol , vol.18 , pp. 248-256
    • Visser, J.W.1    Van Bekkum, D.W.2
  • 37
    • 0036081059 scopus 로고    scopus 로고
    • Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S
    • Na Nakorn T, Traver D, Weissman IL, Akashi K. Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. J Clin Invest 2002; 109: 1579-85.
    • (2002) J Clin Invest , vol.109 , pp. 1579-1585
    • Na Nakorn, T.1    Traver, D.2    Weissman, I.L.3    Akashi, K.4
  • 38
    • 0028534860 scopus 로고
    • The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
    • Morrison SJ, Weissman IL. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1994; 1: 661-73.
    • (1994) Immunity , vol.1 , pp. 661-673
    • Morrison, S.J.1    Weissman, I.L.2
  • 39
    • 0024990851 scopus 로고
    • Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells
    • Jones RJ, Wagner JE, Celano P, Zicha MS, Sharkis SJ. Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells. Nature 1990; 347: 188-9.
    • (1990) Nature , vol.347 , pp. 188-189
    • Jones, R.J.1    Wagner, J.E.2    Celano, P.3    Zicha, M.S.4    Sharkis, S.J.5
  • 41
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 1988; 241: 58-62.
    • (1988) Science , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 42
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256: 495-7.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 43
    • 0014667377 scopus 로고
    • Cell sorting: automated separation of mammalian cells as a function of intracellular fluorescence
    • Hulett HR, Bonner WA, Barrett J, Herzenberg LA. Cell sorting: automated separation of mammalian cells as a function of intracellular fluorescence. Science 1969; 166: 747-9.
    • (1969) Science , vol.166 , pp. 747-749
    • Hulett, H.R.1    Bonner, W.A.2    Barrett, J.3    Herzenberg, L.A.4
  • 44
    • 0021261893 scopus 로고
    • Bone marrow cells give rise to distinct cell clones within the thymus
    • Ezine S, Weissman IL, Rouse RV. Bone marrow cells give rise to distinct cell clones within the thymus. Nature 1984; 309: 629-31.
    • (1984) Nature , vol.309 , pp. 629-631
    • Ezine, S.1    Weissman, I.L.2    Rouse, R.V.3
  • 45
    • 0023058277 scopus 로고
    • Isolation of two early B lymphocyte progenitors from mouse marrow: a committed pre-pre-B cell and a clonogenic Thy-1-lo hematopoietic stem cell
    • Muller-Sieburg CE, Whitlock CA, Weissman IL. Isolation of two early B lymphocyte progenitors from mouse marrow: a committed pre-pre-B cell and a clonogenic Thy-1-lo hematopoietic stem cell. Cell 1986; 44: 653-62.
    • (1986) Cell , vol.44 , pp. 653-662
    • Muller-Sieburg, C.E.1    Whitlock, C.A.2    Weissman, I.L.3
  • 46
    • 0014073480 scopus 로고
    • A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells
    • Wu AM, Till JE, Siminovitch L, McCulloch EA. A cytological study of the capacity for differentiation of normal hemopoietic colony-forming cells. J Cell Physiol 1967; 69: 177-84.
    • (1967) J Cell Physiol , vol.69 , pp. 177-184
    • Wu, A.M.1    Till, J.E.2    Siminovitch, L.3    McCulloch, E.A.4
  • 47
    • 0017694555 scopus 로고
    • Conditions controlling the proliferation of haemopoietic stem cells in vitro
    • Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 1977; 91: 335-44.
    • (1977) J Cell Physiol , vol.91 , pp. 335-344
    • Dexter, T.M.1    Allen, T.D.2    Lajtha, L.G.3
  • 48
    • 0025949897 scopus 로고
    • Culture of phenotypically defined hematopoietic stem cells and other progenitors at limiting dilution on Dexter monolayers
    • Weilbaecher K, Weissman I, Blume K, Heimfeld S. Culture of phenotypically defined hematopoietic stem cells and other progenitors at limiting dilution on Dexter monolayers. Blood 1991; 78: 945-52.
    • (1991) Blood , vol.78 , pp. 945-952
    • Weilbaecher, K.1    Weissman, I.2    Blume, K.3    Heimfeld, S.4
  • 49
    • 0025762436 scopus 로고
    • Regulation of primitive human hematopoietic cells in long-term marrow culture
    • Eaves CJ, Sutherland HJ, Cashman JD et al. Regulation of primitive human hematopoietic cells in long-term marrow culture. Semin Hematol 1991; 28: 126-31.
    • (1991) Semin Hematol , vol.28 , pp. 126-131
    • Eaves, C.J.1    Sutherland, H.J.2    Cashman, J.D.3
  • 51
    • 0034749999 scopus 로고    scopus 로고
    • Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity
    • Adolfsson J, Borge OJ, Bryder D et al. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 2001; 15: 659-69.
    • (2001) Immunity , vol.15 , pp. 659-669
    • Adolfsson, J.1    Borge, O.J.2    Bryder, D.3
  • 52
    • 0035807964 scopus 로고    scopus 로고
    • Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells
    • Christensen JL, Weissman IL. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A 2001; 98: 14541-6.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 14541-6
    • Christensen, J.L.1    Weissman, I.L.2
  • 53
    • 0026500983 scopus 로고
    • Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation
    • Ikuta K, Weissman IL. Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci U S A 1992; 89: 1502-6.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 1502-1506
    • Ikuta, K.1    Weissman, I.L.2
  • 54
    • 0026502896 scopus 로고
    • Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin-Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow
    • Uchida N, Weissman IL. Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin-Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J Exp Med 1992; 175: 175-84.
    • (1992) J Exp Med , vol.175 , pp. 175-184
    • Uchida, N.1    Weissman, I.L.2
  • 56
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel MJ, Yilmaz OH, Iwashita T, Yilmaz OH, Terhorst C, Morrison SJ. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 2005; 121: 1109-21.
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3    Yilmaz, O.H.4    Terhorst, C.5    Morrison, S.J.6
  • 57
    • 0021250078 scopus 로고
    • Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells
    • Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J Immunol 1984; 133: 157-65.
    • (1984) J Immunol , vol.133 , pp. 157-165
    • Civin, C.I.1    Strauss, L.C.2    Brovall, C.3    Fackler, M.J.4    Schwartz, J.F.5    Shaper, J.H.6
  • 59
    • 0032578385 scopus 로고    scopus 로고
    • HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells
    • Uchida N, Sutton RE, Friera AM et al. HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells. Proc Natl Acad Sci U S A 1998; 95: 11939-44.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11939-44
    • Uchida, N.1    Sutton, R.E.2    Friera, A.M.3
  • 60
    • 0029977501 scopus 로고    scopus 로고
    • Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin
    • Petzer AL, Zandstra PW, Piret JM, Eaves CJ. Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. J Exp Med 1996; 183: 2551-8.
    • (1996) J Exp Med , vol.183 , pp. 2551-2558
    • Petzer, A.L.1    Zandstra, P.W.2    Piret, J.M.3    Eaves, C.J.4
  • 61
    • 16144365969 scopus 로고    scopus 로고
    • Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy
    • Larochelle A, Vormoor J, Hanenberg H et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med 1996; 2: 1329-37.
    • (1996) Nat Med , vol.2 , pp. 1329-1337
    • Larochelle, A.1    Vormoor, J.2    Hanenberg, H.3
  • 62
    • 0030911358 scopus 로고    scopus 로고
    • Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
    • Bhatia M, Wang JC, Kapp U, Bonnet D, Dick JE. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A 1997; 94: 5320-5.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5320-5325
    • Bhatia, M.1    Wang, J.C.2    Kapp, U.3    Bonnet, D.4    Dick, J.E.5
  • 63
    • 36749098400 scopus 로고    scopus 로고
    • Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood
    • Majeti R, Park CS, Weissman IL. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 2007; 1: 635-45.
    • (2007) Cell Stem Cell , vol.1 , pp. 635-645
    • Majeti, R.1    Park, C.S.2    Weissman, I.L.3
  • 64
    • 0028337822 scopus 로고
    • Human fetal bone marrow early progenitors for T, B, and myeloid cells are found exclusively in the population expressing high levels of CD34
    • DiGiusto D, Chen S, Combs J et al. Human fetal bone marrow early progenitors for T, B, and myeloid cells are found exclusively in the population expressing high levels of CD34. Blood 1994; 84: 421-32.
    • (1994) Blood , vol.84 , pp. 421-432
    • DiGiusto, D.1    Chen, S.2    Combs, J.3
  • 65
    • 0031671642 scopus 로고    scopus 로고
    • A newly discovered class of human hematopoietic cells with SCID-repopulating activity
    • Bhatia M, Bonnet D, Murdoch B, Gan OI, Dick JE. A newly discovered class of human hematopoietic cells with SCID-repopulating activity. Nat Med 1998; 4: 1038-45.
    • (1998) Nat Med , vol.4 , pp. 1038-1045
    • Bhatia, M.1    Bonnet, D.2    Murdoch, B.3    Gan, O.I.4    Dick, J.E.5
  • 66
    • 0031435428 scopus 로고    scopus 로고
    • Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
    • Goodell MA, Rosenzweig M, Kim H et al. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 1997; 3: 1337-45.
    • (1997) Nat Med , vol.3 , pp. 1337-1345
    • Goodell, M.A.1    Rosenzweig, M.2    Kim, H.3
  • 67
    • 0031979170 scopus 로고    scopus 로고
    • Human bone marrow CD34-cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34+ cells
    • Zanjani ED, Almeida-Porada G, Livingston AG, Flake AW, Ogawa M. Human bone marrow CD34-cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34+ cells. Exp Hematol 1998; 26: 353-60.
    • (1998) Exp Hematol , vol.26 , pp. 353-360
    • Zanjani, E.D.1    Almeida-Porada, G.2    Livingston, A.G.3    Flake, A.W.4    Ogawa, M.5
  • 68
    • 0035896731 scopus 로고    scopus 로고
    • Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
    • Allsopp RC, Cheshier S, Weissman IL. Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J Exp Med 2001; 193: 917-24.
    • (2001) J Exp Med , vol.193 , pp. 917-924
    • Allsopp, R.C.1    Cheshier, S.2    Weissman, I.L.3
  • 69
    • 0032980506 scopus 로고    scopus 로고
    • In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
    • Cheshier SH, Morrison SJ, Liao X, Weissman IL. In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A 1999; 96: 3120-5.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3120-3125
    • Cheshier, S.H.1    Morrison, S.J.2    Liao, X.3    Weissman, I.L.4
  • 70
    • 28544436371 scopus 로고    scopus 로고
    • Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    • Passegue E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 2005; 202: 1599-611.
    • (2005) J Exp Med , vol.202 , pp. 1599-1611
    • Passegue, E.1    Wagers, A.J.2    Giuriato, S.3    Anderson, W.C.4    Weissman, I.L.5
  • 71
    • 84890659395 scopus 로고    scopus 로고
    • Weissman IL. Unpublished observations
    • Ooi L, Bhattacharya D, Rossi D, Weissman IL. Unpublished observations, 2008.
    • (2008)
    • Ooi, L.1    Bhattacharya, D.2    Rossi, D.3
  • 72
    • 0035871894 scopus 로고    scopus 로고
    • Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle
    • Wright DE, Cheshier SH, Wagers AJ, Randall TD, Christensen JL, Weissman IL. Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood 2001; 97: 2278-85.
    • (2001) Blood , vol.97 , pp. 2278-2285
    • Wright, D.E.1    Cheshier, S.H.2    Wagers, A.J.3    Randall, T.D.4    Christensen, J.L.5    Weissman, I.L.6
  • 73
    • 0027185511 scopus 로고
    • Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells
    • Fleming WH, Alpern EJ, Uchida N, Ikuta K, Spangrude GJ, Weissman IL. Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. J Cell Biol 1993; 122: 897-902.
    • (1993) J Cell Biol , vol.122 , pp. 897-902
    • Fleming, W.H.1    Alpern, E.J.2    Uchida, N.3    Ikuta, K.4    Spangrude, G.J.5    Weissman, I.L.6
  • 74
    • 0031059252 scopus 로고    scopus 로고
    • Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization
    • Morrison SJ, Wright DE, Weissman IL. Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization. Proc Natl Acad Sci U S A 1997; 94: 1908-13.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 1908-1913
    • Morrison, S.J.1    Wright, D.E.2    Weissman, I.L.3
  • 76
    • 36249023751 scopus 로고    scopus 로고
    • The effect of bleeding on hematopoietic stem cell cycling and self-renewal
    • Cheshier SH, Prohaska SS, Weissman IL. The effect of bleeding on hematopoietic stem cell cycling and self-renewal. Stem Cell Dev 2007; 16: 707-17.
    • (2007) Stem Cell Dev , vol.16 , pp. 707-717
    • Cheshier, S.H.1    Prohaska, S.S.2    Weissman, I.L.3
  • 77
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965; 37: 614-36.
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 79
    • 0029155795 scopus 로고
    • Telomerase in yeast
    • Cohn M, Blackburn EH. Telomerase in yeast. Science 1995; 269: 396-400.
    • (1995) Science , vol.269 , pp. 396-400
    • Cohn, M.1    Blackburn, E.H.2
  • 80
    • 0037011023 scopus 로고    scopus 로고
    • Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells
    • Allsopp RC, Cheshier S, Weissman IL. Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells. J Exp Med 2002; 196: 1427-33.
    • (2002) J Exp Med , vol.196 , pp. 1427-1433
    • Allsopp, R.C.1    Cheshier, S.2    Weissman, I.L.3
  • 81
    • 0030248792 scopus 로고    scopus 로고
    • Telomerase activity in hematopoietic cells is associated with self-renewal potential
    • Morrison SJ, Prowse KR, Ho P, Weissman IL. Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 1996; 5: 207-16.
    • (1996) Immunity , vol.5 , pp. 207-216
    • Morrison, S.J.1    Prowse, K.R.2    Ho, P.3    Weissman, I.L.4
  • 82
    • 34247115962 scopus 로고    scopus 로고
    • Telomeres and telomerase as targets for cancer therapy
    • Zimmermann S, Martens UM. Telomeres and telomerase as targets for cancer therapy. Cell Mol Life Sci 2007; 64: 906-21.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 906-921
    • Zimmermann, S.1    Martens, U.M.2
  • 84
    • 0037080188 scopus 로고    scopus 로고
    • A genetic determinant that specifically regulates the frequency of hematopoietic stem cells
    • Morrison SJ, Qian D, Jerabek L et al. A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol 2002; 168: 635-42.
    • (2002) J Immunol , vol.168 , pp. 635-642
    • Morrison, S.J.1    Qian, D.2    Jerabek, L.3
  • 85
    • 0029917125 scopus 로고    scopus 로고
    • Genetic control of the frequency of hematopoietic stem cells in mice: mapping of a candidate locus to chromosome 1
    • Muller-Sieburg CE, Riblet R. Genetic control of the frequency of hematopoietic stem cells in mice: mapping of a candidate locus to chromosome 1. J Exp Med 1996; 183: 1141-50.
    • (1996) J Exp Med , vol.183 , pp. 1141-1150
    • Muller-Sieburg, C.E.1    Riblet, R.2
  • 86
    • 33846621063 scopus 로고    scopus 로고
    • Latexin is a newly discovered regulator of hematopoietic stem cells
    • de Haan G. Latexin is a newly discovered regulator of hematopoietic stem cells. Nat Genet 2007; 39: 141-2.
    • (2007) Nat Genet , vol.39 , pp. 141-142
    • de Haan, G.1
  • 87
    • 0032055166 scopus 로고    scopus 로고
    • Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation
    • Domen J, Gandy KL, Weissman IL. Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood 1998; 91: 2272-82.
    • (1998) Blood , vol.91 , pp. 2272-2282
    • Domen, J.1    Gandy, K.L.2    Weissman, I.L.3
  • 88
    • 0034684662 scopus 로고    scopus 로고
    • Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other
    • Domen J, Weissman IL. Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other. J Exp Med 2000; 192: 1707-18.
    • (2000) J Exp Med , vol.192 , pp. 1707-1718
    • Domen, J.1    Weissman, I.L.2
  • 89
    • 0037100461 scopus 로고    scopus 로고
    • Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro
    • Lacaud G, Gore L, Kennedy M et al. Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood 2002; 100: 458-66.
    • (2002) Blood , vol.100 , pp. 458-466
    • Lacaud, G.1    Gore, L.2    Kennedy, M.3
  • 90
    • 12244309510 scopus 로고    scopus 로고
    • SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation
    • Endoh M, Ogawa M, Orkin S, Nishikawa S. SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. EMBO J 2002; 21: 6700-8.
    • (2002) EMBO J , vol.21 , pp. 6700-6708
    • Endoh, M.1    Ogawa, M.2    Orkin, S.3    Nishikawa, S.4
  • 91
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • Shalaby F, Rossant J, Yamaguchi TP et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995; 376: 62-6.
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3
  • 92
    • 0030831104 scopus 로고    scopus 로고
    • A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis
    • Shalaby F, Ho J, Stanford WL et al. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 1997; 89: 981-90.
    • (1997) Cell , vol.89 , pp. 981-990
    • Shalaby, F.1    Ho, J.2    Stanford, W.L.3
  • 94
    • 0037968549 scopus 로고    scopus 로고
    • Gene expression analysis of purified hematopoietic stem cells and committed progenitors
    • Terskikh AV, Miyamoto T, Chang C, Diatchenko L, Weissman IL. Gene expression analysis of purified hematopoietic stem cells and committed progenitors. Blood 2003; 102: 94-101.
    • (2003) Blood , vol.102 , pp. 94-101
    • Terskikh, A.V.1    Miyamoto, T.2    Chang, C.3    Diatchenko, L.4    Weissman, I.L.5
  • 95
    • 8844250116 scopus 로고    scopus 로고
    • Molecular signatures of proliferation and quiescence in hematopoietic stem cells
    • Venezia TA, Merchant AA, Ramos CA et al. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol 2004; 2: e301.
    • (2004) PLoS Biol , vol.2
    • Venezia, T.A.1    Merchant, A.A.2    Ramos, C.A.3
  • 96
    • 21544467270 scopus 로고    scopus 로고
    • Cell intrinsic alterations underlie hematopoietic stem cell aging
    • Rossi DJ, Bryder D, Zahn JM et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A 2005; 102: 9194-9.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9194-9199
    • Rossi, D.J.1    Bryder, D.2    Zahn, J.M.3
  • 97
    • 0037079712 scopus 로고    scopus 로고
    • Differential gene expression profiling of adult murine hematopoietic stem cells
    • Park IK, He Y, Lin F et al. Differential gene expression profiling of adult murine hematopoietic stem cells. Blood 2002; 99: 488-98.
    • (2002) Blood , vol.99 , pp. 488-498
    • Park, I.K.1    He, Y.2    Lin, F.3
  • 98
    • 0034595656 scopus 로고    scopus 로고
    • The genetic program of hematopoietic stem cells
    • Phillips RL, Ernst RE, Brunk B et al. The genetic program of hematopoietic stem cells. Science 2000; 288: 1635-40.
    • (2000) Science , vol.288 , pp. 1635-1640
    • Phillips, R.L.1    Ernst, R.E.2    Brunk, B.3
  • 99
    • 0034283746 scopus 로고    scopus 로고
    • Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro
    • Bryder D, Jacobsen SE. Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro. Blood 2000; 96: 1748-55.
    • (2000) Blood , vol.96 , pp. 1748-1755
    • Bryder, D.1    Jacobsen, S.E.2
  • 100
    • 0030886656 scopus 로고    scopus 로고
    • Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice
    • Conneally E, Cashman J, Petzer A, Eaves C. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci U S A 1997; 94: 9836-41.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9836-9841
    • Conneally, E.1    Cashman, J.2    Petzer, A.3    Eaves, C.4
  • 101
    • 0034613735 scopus 로고    scopus 로고
    • In vitro self-renewal division of hematopoietic stem cells
    • Ema H, Takano H, Sudo K, Nakauchi H. In vitro self-renewal division of hematopoietic stem cells. J Exp Med 2000; 192: 1281-8.
    • (2000) J Exp Med , vol.192 , pp. 1281-1288
    • Ema, H.1    Takano, H.2    Sudo, K.3    Nakauchi, H.4
  • 102
    • 0025030443 scopus 로고
    • Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells
    • Fraser CC, Eaves CJ, Szilvassy SJ, Humphries RK. Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells. Blood 1990; 76: 1071-6.
    • (1990) Blood , vol.76 , pp. 1071-1076
    • Fraser, C.C.1    Eaves, C.J.2    Szilvassy, S.J.3    Humphries, R.K.4
  • 103
    • 0036565889 scopus 로고    scopus 로고
    • Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice
    • Glimm H, Tang P, Clark-Lewis I, von Kalle C, Eaves C. Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice. Blood 2002; 99: 3454-7.
    • (2002) Blood , vol.99 , pp. 3454-3457
    • Glimm, H.1    Tang, P.2    Clark-Lewis, I.3    von Kalle, C.4    Eaves, C.5
  • 104
    • 0031440921 scopus 로고    scopus 로고
    • Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability
    • Miller CL, Eaves CJ. Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. Proc Natl Acad Sci U S A 1997; 94: 13648-53.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 13648-53
    • Miller, C.L.1    Eaves, C.J.2
  • 106
    • 0000259016 scopus 로고
    • The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl-Sld
    • McCulloch EA, Siminovitch L, Till JE, Russell ES, Bernstein SE. The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl-Sld. Blood 1965; 26: 399-410.
    • (1965) Blood , vol.26 , pp. 399-410
    • McCulloch, E.A.1    Siminovitch, L.2    Till, J.E.3    Russell, E.S.4    Bernstein, S.E.5
  • 107
    • 0025077796 scopus 로고
    • The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus
    • Huang E, Nocka K, Beier DR et al. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 1990; 63: 225-33.
    • (1990) Cell , vol.63 , pp. 225-233
    • Huang, E.1    Nocka, K.2    Beier, D.R.3
  • 108
    • 84989638036 scopus 로고
    • Steel, a new dominant gene in the house mouse
    • Sarvella PA, Russel LB. Steel, a new dominant gene in the house mouse. J Hered 1956; 47: 390.
    • (1956) J Hered , vol.47 , pp. 390
    • Sarvella, P.A.1    Russel, L.B.2
  • 109
    • 0025013548 scopus 로고
    • Identification of a ligand for the c-kit proto-oncogene
    • Williams DE, Eisenman J, Baird A et al. Identification of a ligand for the c-kit proto-oncogene. Cell 1990; 63: 167-74.
    • (1990) Cell , vol.63 , pp. 167-174
    • Williams, D.E.1    Eisenman, J.2    Baird, A.3
  • 110
    • 0024280901 scopus 로고
    • The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
    • Geissler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 1988; 55: 185-92.
    • (1988) Cell , vol.55 , pp. 185-192
    • Geissler, E.N.1    Ryan, M.A.2    Housman, D.E.3
  • 111
    • 0023694835 scopus 로고
    • The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    • Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A. The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 1988; 335: 88-9.
    • (1988) Nature , vol.335 , pp. 88-89
    • Chabot, B.1    Stephenson, D.A.2    Chapman, V.M.3    Besmer, P.4    Bernstein, A.5
  • 112
    • 0028252924 scopus 로고
    • Steel factor and c-kit protooncogene: genetic lessons in signal transduction
    • Lev S, Blechman JM, Givol D, Yarden Y. Steel factor and c-kit protooncogene: genetic lessons in signal transduction. Crit Rev Oncog 1994; 5: 141-68.
    • (1994) Crit Rev Oncog , vol.5 , pp. 141-168
    • Lev, S.1    Blechman, J.M.2    Givol, D.3    Yarden, Y.4
  • 113
    • 0036070180 scopus 로고    scopus 로고
    • Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment
    • Miyamoto T, Iwasaki H, Reizis B et al. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell 2002; 3: 137-47.
    • (2002) Dev Cell , vol.3 , pp. 137-147
    • Miyamoto, T.1    Iwasaki, H.2    Reizis, B.3
  • 114
    • 36749001043 scopus 로고    scopus 로고
    • Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
    • Qian H, Buza-Vidas N, Hyland CD et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 2007; 1: 671-84.
    • (2007) Cell Stem Cell , vol.1 , pp. 671-684
    • Qian, H.1    Buza-Vidas, N.2    Hyland, C.D.3
  • 115
    • 36748999351 scopus 로고    scopus 로고
    • Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
    • Yoshihara H, Arai F, Hosokawa K et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007; 1: 685-97.
    • (2007) Cell Stem Cell , vol.1 , pp. 685-697
    • Yoshihara, H.1    Arai, F.2    Hosokawa, K.3
  • 116
    • 0034613734 scopus 로고    scopus 로고
    • The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
    • Karanu FN, Murdoch B, Gallacher L et al. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J Exp Med 2000; 192: 1365-72.
    • (2000) J Exp Med , vol.192 , pp. 1365-1372
    • Karanu, F.N.1    Murdoch, B.2    Gallacher, L.3
  • 117
    • 0033694305 scopus 로고    scopus 로고
    • Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
    • Varnum-Finney B, Xu L, Brashem-Stein C et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med 2000; 6: 1278-81.
    • (2000) Nat Med , vol.6 , pp. 1278-1281
    • Varnum-Finney, B.1    Xu, L.2    Brashem-Stein, C.3
  • 118
    • 0037023544 scopus 로고    scopus 로고
    • HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors
    • Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 2002; 109: 29-37.
    • (2002) Cell , vol.109 , pp. 29-37
    • Kyba, M.1    Perlingeiro, R.C.2    Daley, G.Q.3
  • 119
    • 0034892945 scopus 로고    scopus 로고
    • HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation
    • Antonchuk J, Sauvageau G, Humphries RK. HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp Hematol 2001; 29: 1125-34.
    • (2001) Exp Hematol , vol.29 , pp. 1125-1134
    • Antonchuk, J.1    Sauvageau, G.2    Humphries, R.K.3
  • 120
    • 0037023528 scopus 로고    scopus 로고
    • HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    • Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 2002; 109: 39-45.
    • (2002) Cell , vol.109 , pp. 39-45
    • Antonchuk, J.1    Sauvageau, G.2    Humphries, R.K.3
  • 121
    • 0029091845 scopus 로고
    • Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
    • Sauvageau G, Thorsteinsdottir U, Eaves CJ et al. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 1995; 9: 1753-65.
    • (1995) Genes Dev , vol.9 , pp. 1753-1765
    • Sauvageau, G.1    Thorsteinsdottir, U.2    Eaves, C.J.3
  • 123
    • 34748837360 scopus 로고    scopus 로고
    • Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis
    • Katoh M. Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. Stem Cell Rev 2007; 3: 30-8.
    • (2007) Stem Cell Rev , vol.3 , pp. 30-38
    • Katoh, M.1
  • 124
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya T, Duncan AW, Ailles L et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003; 423: 409-14.
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1    Duncan, A.W.2    Ailles, L.3
  • 125
    • 0037737726 scopus 로고    scopus 로고
    • Wnt proteins are lipid-modified and can act as stem cell growth factors
    • Willert K, Brown JD, Danenberg E et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003; 423: 448-52.
    • (2003) Nature , vol.423 , pp. 448-452
    • Willert, K.1    Brown, J.D.2    Danenberg, E.3
  • 126
    • 1642499734 scopus 로고    scopus 로고
    • Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
    • Cobas M, Wilson A, Ernst B et al. Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med 2004; 199: 221-9.
    • (2004) J Exp Med , vol.199 , pp. 221-229
    • Cobas, M.1    Wilson, A.2    Ernst, B.3
  • 127
    • 36649002031 scopus 로고    scopus 로고
    • Loss of betacatenin impairs the renewal of normal and CML stem cells in vivo
    • Zhao C, Blum J, Chen A et al. Loss of betacatenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 2007; 12: 528-41.
    • (2007) Cancer Cell , vol.12 , pp. 528-541
    • Zhao, C.1    Blum, J.2    Chen, A.3
  • 128
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003; 423: 302-5.
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3
  • 129
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycombgroup gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycombgroup gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999; 397: 164-8.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    van Lohuizen, M.5
  • 130
    • 0028079924 scopus 로고
    • Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells
    • Sauvageau G, Lansdorp PM, Eaves CJ et al. Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci U S A 1994; 91: 12223-7.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12223-7
    • Sauvageau, G.1    Lansdorp, P.M.2    Eaves, C.J.3
  • 131
    • 7044269527 scopus 로고    scopus 로고
    • JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells
    • Passegue E, Wagner EF, Weissman IL. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 2004; 119: 431-43.
    • (2004) Cell , vol.119 , pp. 431-443
    • Passegue, E.1    Wagner, E.F.2    Weissman, I.L.3
  • 132
    • 0000124617 scopus 로고
    • Evidence for stem cells in the peripheral blood of mice
    • Goodman JW, Hodgson GS. Evidence for stem cells in the peripheral blood of mice. Blood 1962; 19: 702-14.
    • (1962) Blood , vol.19 , pp. 702-714
    • Goodman, J.W.1    Hodgson, G.S.2
  • 133
    • 0017165031 scopus 로고
    • Increase in circulating stem cells following chemotherapy in man
    • Richman CM, Weiner RS, Yankee RA. Increase in circulating stem cells following chemotherapy in man. Blood 1976; 47: 1031-9.
    • (1976) Blood , vol.47 , pp. 1031-1039
    • Richman, C.M.1    Weiner, R.S.2    Yankee, R.A.3
  • 134
    • 0022349573 scopus 로고
    • Circulating autologous stem cells collected in very early remission from acute nonlymphoblastic leukaemia produce prompt but incomplete haemopoietic reconstitution after high dose melphalan or supralethal chemoradiotherapy
    • Juttner CA, To LB, Haylock DN, Branford A, Kimber RJ. Circulating autologous stem cells collected in very early remission from acute nonlymphoblastic leukaemia produce prompt but incomplete haemopoietic reconstitution after high dose melphalan or supralethal chemoradiotherapy. Br J Haematol 1985; 61: 739-45.
    • (1985) Br J Haematol , vol.61 , pp. 739-745
    • Juttner, C.A.1    To, L.B.2    Haylock, D.N.3    Branford, A.4    Kimber, R.J.5
  • 135
    • 0026518567 scopus 로고
    • Mobilization of peripheral blood progenitor cells by sequential administration of interleukin-3 and granulocytemacrophage colony-stimulating factor following polychemotherapy with etoposide, ifosfamide, and cisplatin
    • Brugger W, Bross K, Frisch J et al. Mobilization of peripheral blood progenitor cells by sequential administration of interleukin-3 and granulocytemacrophage colony-stimulating factor following polychemotherapy with etoposide, ifosfamide, and cisplatin. Blood 1992; 79: 1193-200.
    • (1992) Blood , vol.79 , pp. 1193-1200
    • Brugger, W.1    Bross, K.2    Frisch, J.3
  • 136
    • 0024271198 scopus 로고
    • Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients
    • Duhrsen U, Villeval JL, Boyd J, Kannourakis G, Morstyn G, Metcalf D. Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 1988; 72: 2074-81.
    • (1988) Blood , vol.72 , pp. 2074-2081
    • Duhrsen, U.1    Villeval, J.L.2    Boyd, J.3    Kannourakis, G.4    Morstyn, G.5    Metcalf, D.6
  • 137
    • 0025898727 scopus 로고
    • Recombinant human stem cell factor synergises with GMCSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages
    • McNiece IK, Langley KE, Zsebo KM. Recombinant human stem cell factor synergises with GMCSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages. Exp Hematol 1991; 19: 226-31.
    • (1991) Exp Hematol , vol.19 , pp. 226-231
    • McNiece, I.K.1    Langley, K.E.2    Zsebo, K.M.3
  • 138
    • 0024439774 scopus 로고
    • Circulation of CD34+ hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide-treated patients: enhancement by intravenous recombinant human granulocyte-macrophage colony-stimulating factor
    • Siena S, Bregni M, Brando B, Ravagnani F, Bonadonna G, Gianni AM. Circulation of CD34+ hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide-treated patients: enhancement by intravenous recombinant human granulocyte-macrophage colony-stimulating factor. Blood 1989; 74: 1905-14.
    • (1989) Blood , vol.74 , pp. 1905-1914
    • Siena, S.1    Bregni, M.2    Brando, B.3    Ravagnani, F.4    Bonadonna, G.5    Gianni, A.M.6
  • 139
    • 0023905129 scopus 로고
    • Granulocyte-macrophage colony stimulating factor expands the circulating haemopoietic progenitor cell compartment in man
    • Socinski MA, Cannistra SA, Elias A, Antman KH, Schnipper L, Griffin JD. Granulocyte-macrophage colony stimulating factor expands the circulating haemopoietic progenitor cell compartment in man. Lancet 1988; 1: 1194-8.
    • (1988) Lancet , vol.1 , pp. 1194-1198
    • Socinski, M.A.1    Cannistra, S.A.2    Elias, A.3    Antman, K.H.4    Schnipper, L.5    Griffin, J.D.6
  • 140
    • 0034945086 scopus 로고    scopus 로고
    • From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs
    • Terskikh AV, Easterday MC, Li L et al. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A 2001; 98: 7934-9.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7934-7939
    • Terskikh, A.V.1    Easterday, M.C.2    Li, L.3
  • 141
    • 0033062818 scopus 로고    scopus 로고
    • Biology of IL-8-induced stem cell mobilization
    • Fibbe WE, Pruijt JF, Velders GA et al. Biology of IL-8-induced stem cell mobilization. Ann N Y Acad Sci 1999; 872: 71-82.
    • (1999) Ann N Y Acad Sci , vol.872 , pp. 71-82
    • Fibbe, W.E.1    Pruijt, J.F.2    Velders, G.A.3
  • 142
    • 18444389451 scopus 로고    scopus 로고
    • Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kitligand
    • Heissig B, Hattori K, Dias S et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kitligand. Cell 2002; 109: 625-37.
    • (2002) Cell , vol.109 , pp. 625-637
    • Heissig, B.1    Hattori, K.2    Dias, S.3
  • 143
    • 0028967518 scopus 로고
    • Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability
    • Laterveer L, Lindley IJ, Hamilton MS, Willemze R, Fibbe WE. Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability. Blood 1995; 85: 2269-75.
    • (1995) Blood , vol.85 , pp. 2269-2275
    • Laterveer, L.1    Lindley, I.J.2    Hamilton, M.S.3    Willemze, R.4    Fibbe, W.E.5
  • 144
    • 0026035375 scopus 로고
    • Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis
    • Miyake K, Weissman IL, Greenberger JS, Kincade PW. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J Exp Med 1991; 173: 599-607.
    • (1991) J Exp Med , vol.173 , pp. 599-607
    • Miyake, K.1    Weissman, I.L.2    Greenberger, J.S.3    Kincade, P.W.4
  • 145
    • 0026071513 scopus 로고
    • Identification of a 107-kD glycoprotein that mediates adhesion between stromal cells and hematolymphoid cells
    • Kina T, Majumdar AS, Heimfeld S et al. Identification of a 107-kD glycoprotein that mediates adhesion between stromal cells and hematolymphoid cells. J Exp Med 1991; 173: 373-81.
    • (1991) J Exp Med , vol.173 , pp. 373-381
    • Kina, T.1    Majumdar, A.S.2    Heimfeld, S.3
  • 146
    • 0025161990 scopus 로고
    • VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
    • Elices MJ, Osborn L, Takada Y et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990; 60: 577-84.
    • (1990) Cell , vol.60 , pp. 577-584
    • Elices, M.J.1    Osborn, L.2    Takada, Y.3
  • 147
    • 0030030009 scopus 로고    scopus 로고
    • Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues
    • Schweitzer KM, Drager AM, van der Valk P et al. Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues. Am J Pathol 1996; 148: 165-75.
    • (1996) Am J Pathol , vol.148 , pp. 165-175
    • Schweitzer, K.M.1    Drager, A.M.2    van der Valk, P.3
  • 148
    • 0036141664 scopus 로고    scopus 로고
    • Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor
    • Wagers AJ, Allsopp RC, Weissman IL. Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor. Exp Hematol 2002; 30: 176-85.
    • (2002) Exp Hematol , vol.30 , pp. 176-185
    • Wagers, A.J.1    Allsopp, R.C.2    Weissman, I.L.3
  • 149
    • 2642710893 scopus 로고    scopus 로고
    • The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1
    • Mohle R, Bautz F, Rafii S, Moore MA, Brugger W, Kanz L. The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood 1998; 91: 4523-30.
    • (1998) Blood , vol.91 , pp. 4523-4530
    • Mohle, R.1    Bautz, F.2    Rafii, S.3    Moore, M.A.4    Brugger, W.5    Kanz, L.6
  • 150
    • 0033524834 scopus 로고    scopus 로고
    • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    • Peled A, Petit I, Kollet O et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999; 283: 845-8.
    • (1999) Science , vol.283 , pp. 845-848
    • Peled, A.1    Petit, I.2    Kollet, O.3
  • 151
    • 0037029654 scopus 로고    scopus 로고
    • Hematopoietic stem cells are uniquely selective in their migratory response to chemokines
    • Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med 2002; 195: 1145-54.
    • (2002) J Exp Med , vol.195 , pp. 1145-1154
    • Wright, D.E.1    Bowman, E.P.2    Wagers, A.J.3    Butcher, E.C.4    Weissman, I.L.5
  • 152
    • 0015707646 scopus 로고
    • Homing properties of thymus-independent follicular lymphocytes
    • Gutman GA, Weissman IL. Homing properties of thymus-independent follicular lymphocytes. Transplantation 1973; 16: 621-9.
    • (1973) Transplantation , vol.16 , pp. 621-629
    • Gutman, G.A.1    Weissman, I.L.2
  • 154
    • 0031587848 scopus 로고    scopus 로고
    • Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice
    • Lagasse E, Weissman IL. Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 1997; 89: 1021-31.
    • (1997) Cell , vol.89 , pp. 1021-1031
    • Lagasse, E.1    Weissman, I.L.2
  • 155
    • 36248957063 scopus 로고    scopus 로고
    • Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues
    • Massberg S, Schaerli P, Knezevic-Maramica I et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 2007; 131: 994-1008.
    • (2007) Cell , vol.131 , pp. 994-1008
    • Massberg, S.1    Schaerli, P.2    Knezevic-Maramica, I.3
  • 156
    • 31344461821 scopus 로고    scopus 로고
    • Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning
    • Bhattacharya D, Rossi DJ, Bryder D, Weissman IL. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med 2006; 203: 73-85.
    • (2006) J Exp Med , vol.203 , pp. 73-85
    • Bhattacharya, D.1    Rossi, D.J.2    Bryder, D.3    Weissman, I.L.4
  • 157
    • 36448992228 scopus 로고    scopus 로고
    • Efficient transplantation via antibodybased clearance of hematopoietic stem cell niches
    • Czechowicz A, Kraft D, Weissman IL, Bhattacharya D. Efficient transplantation via antibodybased clearance of hematopoietic stem cell niches. Science 2007; 318: 1296-9.
    • (2007) Science , vol.318 , pp. 1296-1299
    • Czechowicz, A.1    Kraft, D.2    Weissman, I.L.3    Bhattacharya, D.4
  • 160
    • 0014744817 scopus 로고
    • Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo
    • Moore MA, Metcalf D. Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol 1970; 18: 279-96.
    • (1970) Br J Haematol , vol.18 , pp. 279-296
    • Moore, M.A.1    Metcalf, D.2
  • 161
    • 0016811829 scopus 로고
    • Role of stem cell migration in initiation of mouse foetal liver haemopoiesis
    • Johnson GR, Moore MA. Role of stem cell migration in initiation of mouse foetal liver haemopoiesis. Nature 1975; 258: 726-8.
    • (1975) Nature , vol.258 , pp. 726-728
    • Johnson, G.R.1    Moore, M.A.2
  • 162
    • 0035214419 scopus 로고    scopus 로고
    • The initial phase of embryonic patterning in mammals
    • Gardner RL. The initial phase of embryonic patterning in mammals. Int Rev Cytol 2001; 203: 233-90.
    • (2001) Int Rev Cytol , vol.203 , pp. 233-290
    • Gardner, R.L.1
  • 163
    • 0034813102 scopus 로고    scopus 로고
    • Intraembryonic, but not yolk sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution
    • Cumano A, Ferraz JC, Klaine M, Di Santo JP, Godin I. Intraembryonic, but not yolk sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution. Immunity 2001; 15: 477-85.
    • (2001) Immunity , vol.15 , pp. 477-485
    • Cumano, A.1    Ferraz, J.C.2    Klaine, M.3    Di Santo, J.P.4    Godin, I.5
  • 164
    • 0029645392 scopus 로고
    • Evaluation of chest pain in the emergency department
    • author reply
    • Weissman I, O'Neill WW, Juni JE. Evaluation of chest pain in the emergency department. Ann Intern Med 1995; 123: 314; author reply 317-18.
    • (1995) Ann Intern Med , vol.123
    • Weissman, I.1    O'Neill, W.W.2    Juni, J.E.3
  • 165
    • 0032896679 scopus 로고    scopus 로고
    • Development of the hematopoietic system in the mouse
    • Keller G, Lacaud G, Robertson S. Development of the hematopoietic system in the mouse. Exp Hematol 1999; 27: 777-87.
    • (1999) Exp Hematol , vol.27 , pp. 777-787
    • Keller, G.1    Lacaud, G.2    Robertson, S.3
  • 166
    • 0035412372 scopus 로고    scopus 로고
    • Introduction: spatial origin of murine hematopoietic stem cells
    • Yoder MC. Introduction: spatial origin of murine hematopoietic stem cells. Blood 2001; 98: 3-5.
    • (2001) Blood , vol.98 , pp. 3-5
    • Yoder, M.C.1
  • 167
    • 0033405452 scopus 로고    scopus 로고
    • Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
    • Palis J, Robertson S, Kennedy M, Wall C, Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 1999; 126: 5073-84.
    • (1999) Development , vol.126 , pp. 5073-5084
    • Palis, J.1    Robertson, S.2    Kennedy, M.3    Wall, C.4    Keller, G.5
  • 168
    • 34247601504 scopus 로고    scopus 로고
    • Cell tracing shows the contribution of the yolk sac to adult haematopoiesis
    • Samokhvalov IM, Samokhvalova NI, Nishikawa S. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature 2007; 446: 1056-61.
    • (2007) Nature , vol.446 , pp. 1056-1061
    • Samokhvalov, I.M.1    Samokhvalova, N.I.2    Nishikawa, S.3
  • 169
    • 0015072078 scopus 로고
    • A phase and electron microscopic study of vasculogenesis and erythropoiesis in the yolk sac of the mouse
    • Haar JL, Ackerman GA. A phase and electron microscopic study of vasculogenesis and erythropoiesis in the yolk sac of the mouse. Anat Rec 1971; 170: 199-223.
    • (1971) Anat Rec , vol.170 , pp. 199-223
    • Haar, J.L.1    Ackerman, G.A.2
  • 170
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P, Ferreira V, Breier G et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: 435-9.
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3
  • 171
    • 10344247125 scopus 로고    scopus 로고
    • Haemangioblast commitment is initiated in the primitive streak of the mouse embryo
    • Huber TL, Kouskoff V, Fehling HJ, Palis J, Keller G. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature 2004; 432: 625-30.
    • (2004) Nature , vol.432 , pp. 625-630
    • Huber, T.L.1    Kouskoff, V.2    Fehling, H.J.3    Palis, J.4    Keller, G.5
  • 172
    • 33748951390 scopus 로고    scopus 로고
    • Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands
    • Ueno H, Weissman IL. Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands. Dev Cell 2006; 11: 519-33.
    • (2006) Dev Cell , vol.11 , pp. 519-533
    • Ueno, H.1    Weissman, I.L.2
  • 173
    • 0024205842 scopus 로고
    • Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
    • Williams RL, Hilton DJ, Pease S et al. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 1988; 336: 684-7.
    • (1988) Nature , vol.336 , pp. 684-687
    • Williams, R.L.1    Hilton, D.J.2    Pease, S.3
  • 174
    • 0029965412 scopus 로고    scopus 로고
    • The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts
    • Rebel VI, Miller CL, Eaves CJ, Lansdorp PM. The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts. Blood 1996; 87: 3500-7.
    • (1996) Blood , vol.87 , pp. 3500-3507
    • Rebel, V.I.1    Miller, C.L.2    Eaves, C.J.3    Lansdorp, P.M.4
  • 176
    • 0029991362 scopus 로고    scopus 로고
    • Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins
    • Hirsch E, Iglesias A, Potocnik AJ, Hartmann U, Fassler R. Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins. Nature 1996; 380: 171-5.
    • (1996) Nature , vol.380 , pp. 171-175
    • Hirsch, E.1    Iglesias, A.2    Potocnik, A.J.3    Hartmann, U.4    Fassler, R.5
  • 177
    • 0033672656 scopus 로고    scopus 로고
    • Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow
    • Potocnik AJ, Brakebusch C, Fassler R. Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow. Immunity 2000; 12: 653-63.
    • (2000) Immunity , vol.12 , pp. 653-663
    • Potocnik, A.J.1    Brakebusch, C.2    Fassler, R.3
  • 179
    • 0025062703 scopus 로고
    • A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
    • Ikuta K, Kina T, MacNeil I et al. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 1990; 62: 863-74.
    • (1990) Cell , vol.62 , pp. 863-874
    • Ikuta, K.1    Kina, T.2    MacNeil, I.3
  • 180
    • 0023690608 scopus 로고
    • Developmentally ordered appearance of thymocytes expressing different Tcell antigen receptors
    • Havran WL, Allison JP. Developmentally ordered appearance of thymocytes expressing different Tcell antigen receptors. Nature 1988; 335: 443-5.
    • (1988) Nature , vol.335 , pp. 443-445
    • Havran, W.L.1    Allison, J.P.2
  • 181
    • 1542328965 scopus 로고    scopus 로고
    • Plasticity of adult stem cells
    • Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell 2004; 116: 639-48.
    • (2004) Cell , vol.116 , pp. 639-648
    • Wagers, A.J.1    Weissman, I.L.2
  • 182
    • 0035496938 scopus 로고    scopus 로고
    • Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle
    • Kawada H, Ogawa M. Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle. Blood 2001; 98: 2008-13.
    • (2001) Blood , vol.98 , pp. 2008-2013
    • Kawada, H.1    Ogawa, M.2
  • 184
    • 0032489651 scopus 로고    scopus 로고
    • Muscle regeneration by bone marrow-derived myogenic progenitors
    • Ferrari G, Cusella-De Angelis G, Coletta M et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998; 279: 1528-30.
    • (1998) Science , vol.279 , pp. 1528-1530
    • Ferrari, G.1    Cusella-De Angelis, G.2    Coletta, M.3
  • 185
    • 0033598374 scopus 로고    scopus 로고
    • Dystrophin expression in the mdx mouse restored by stem cell transplantation
    • Gussoni E, Soneoka Y, Strickland CD et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 1999; 401: 390-4.
    • (1999) Nature , vol.401 , pp. 390-394
    • Gussoni, E.1    Soneoka, Y.2    Strickland, C.D.3
  • 186
    • 0033694301 scopus 로고    scopus 로고
    • Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    • Lagasse E, Connors H, Al-Dhalimy M et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000; 6: 1229-34.
    • (2000) Nat Med , vol.6 , pp. 1229-1234
    • Lagasse, E.1    Connors, H.2    Al-Dhalimy, M.3
  • 187
    • 0037464574 scopus 로고    scopus 로고
    • Cell fusion is the principal source of bone-marrowderived hepatocytes
    • Wang X, Willenbring H, Akkari Y et al. Cell fusion is the principal source of bone-marrowderived hepatocytes. Nature 2003; 422: 897-901.
    • (2003) Nature , vol.422 , pp. 897-901
    • Wang, X.1    Willenbring, H.2    Akkari, Y.3
  • 188
    • 17144415893 scopus 로고    scopus 로고
    • Delineating the hepatocyte's hematopoietic fusion partner
    • Willenbring H, Grompe M. Delineating the hepatocyte's hematopoietic fusion partner. Cell Cycle 2004; 3: 1489-91.
    • (2004) Cell Cycle , vol.3 , pp. 1489-1491
    • Willenbring, H.1    Grompe, M.2
  • 189
    • 19344364684 scopus 로고    scopus 로고
    • Hematopoietic cells maintain hematopoietic fates upon entering the brain
    • Massengale M, Wagers AJ, Vogel H, Weissman IL. Hematopoietic cells maintain hematopoietic fates upon entering the brain. J Exp Med 2005; 201: 1579-89.
    • (2005) J Exp Med , vol.201 , pp. 1579-1589
    • Massengale, M.1    Wagers, A.J.2    Vogel, H.3    Weissman, I.L.4
  • 190
    • 0015515283 scopus 로고
    • Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity
    • Giblett ER, Anderson JE, Cohen F, Pollara B, Meuwissen HJ. Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 1972; 2: 1067-9.
    • (1972) Lancet , vol.2 , pp. 1067-1069
    • Giblett, E.R.1    Anderson, J.E.2    Cohen, F.3    Pollara, B.4    Meuwissen, H.J.5
  • 192
    • 0028327550 scopus 로고
    • Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes
    • Kondo M, Takeshita T, Higuchi M et al. Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science 1994; 263: 1453-4.
    • (1994) Science , vol.263 , pp. 1453-1454
    • Kondo, M.1    Takeshita, T.2    Higuchi, M.3
  • 193
    • 0027751556 scopus 로고
    • Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor
    • Noguchi M, Nakamura Y, Russell SM et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 1993; 262: 1877-80.
    • (1993) Science , vol.262 , pp. 1877-1880
    • Noguchi, M.1    Nakamura, Y.2    Russell, S.M.3
  • 194
    • 0027762489 scopus 로고
    • Severe combined immunodeficiency of reduced severity due to homozygosity for an adenosine deaminase missense mutation (Arg253Pro)
    • Hirschhorn R, Yang DR, Insel RA, Ballow M. Severe combined immunodeficiency of reduced severity due to homozygosity for an adenosine deaminase missense mutation (Arg253Pro). Cell Immunol 1993; 152: 383-93.
    • (1993) Cell Immunol , vol.152 , pp. 383-393
    • Hirschhorn, R.1    Yang, D.R.2    Insel, R.A.3    Ballow, M.4
  • 195
    • 0026451087 scopus 로고
    • Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
    • Georgopoulos K, Moore DD, Derfler B. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 1992; 258: 808-12.
    • (1992) Science , vol.258 , pp. 808-812
    • Georgopoulos, K.1    Moore, D.D.2    Derfler, B.3
  • 196
    • 0033136717 scopus 로고    scopus 로고
    • Deficient T cell fate specification in mice with an induced inactivation of Notch1
    • Radtke F, Wilson A, Stark G et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 1999; 10: 547-58.
    • (1999) Immunity , vol.10 , pp. 547-558
    • Radtke, F.1    Wilson, A.2    Stark, G.3
  • 197
    • 0028518592 scopus 로고
    • Stem cells, clonal progenitors, and commitment to the three lymphocyte lineages: T, B, and NK cells
    • Weissman IL. Stem cells, clonal progenitors, and commitment to the three lymphocyte lineages: T, B, and NK cells. Immunity 1994; 1: 529-31.
    • (1994) Immunity , vol.1 , pp. 529-531
    • Weissman, I.L.1
  • 198
    • 0025270752 scopus 로고
    • Acute 'bilineal-biphenotypic' leukaemia
    • Akashi K, Shibuya T, Harada M et al. Acute 'bilineal-biphenotypic' leukaemia. Br J Haematol 1990; 74: 402-7.
    • (1990) Br J Haematol , vol.74 , pp. 402-407
    • Akashi, K.1    Shibuya, T.2    Harada, M.3
  • 199
    • 0026006116 scopus 로고
    • Simultaneous occurrence of myelomonocytic leukemia and multiple myeloma: involvement of common leukemic progenitors and their developmental abnormality of "lineage infidelity"
    • Akashi K, Harada M, Shibuya T et al. Simultaneous occurrence of myelomonocytic leukemia and multiple myeloma: involvement of common leukemic progenitors and their developmental abnormality of "lineage infidelity". J Cell Physiol 1991; 148: 446-56.
    • (1991) J Cell Physiol , vol.148 , pp. 446-456
    • Akashi, K.1    Harada, M.2    Shibuya, T.3
  • 200
    • 0027851828 scopus 로고
    • T lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia
    • Akashi K, Mizuno S, Harada M et al. T lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia. Exp Hematol 1993; 21: 743-8.
    • (1993) Exp Hematol , vol.21 , pp. 743-748
    • Akashi, K.1    Mizuno, S.2    Harada, M.3
  • 201
    • 0027171726 scopus 로고
    • B-lymphoid/myeloid stem cell origin in Ph-positive acute leukemia with myeloid markers
    • Akashi K, Taniguchi S, Nagafuji K et al. B-lymphoid/myeloid stem cell origin in Ph-positive acute leukemia with myeloid markers. Leuk Res 1993; 17: 549-55.
    • (1993) Leuk Res , vol.17 , pp. 549-555
    • Akashi, K.1    Taniguchi, S.2    Nagafuji, K.3
  • 202
    • 0024594241 scopus 로고
    • Plasma cell myeloma -new biological insights and advances in therapy
    • Barlogie B, Epstein J, Selvanayagam P, Alexanian R. Plasma cell myeloma -new biological insights and advances in therapy. Blood 1989; 73: 865-79.
    • (1989) Blood , vol.73 , pp. 865-879
    • Barlogie, B.1    Epstein, J.2    Selvanayagam, P.3    Alexanian, R.4
  • 204
    • 0034990241 scopus 로고    scopus 로고
    • What can we learn from leukemia as for the process of lineage commitment in hematopoiesis?
    • Schmidt CA, Przybylski GK. What can we learn from leukemia as for the process of lineage commitment in hematopoiesis? Int Rev Immunol 2001; 20: 107-15.
    • (2001) Int Rev Immunol , vol.20 , pp. 107-115
    • Schmidt, C.A.1    Przybylski, G.K.2
  • 205
    • 0025339586 scopus 로고
    • Clinical features and biological implications of acute mixed lineage (hybrid) leukemias
    • Altman AJ. Clinical features and biological implications of acute mixed lineage (hybrid) leukemias. Am J Pediatr Hematol Oncol 1990; 12: 123-33.
    • (1990) Am J Pediatr Hematol Oncol , vol.12 , pp. 123-133
    • Altman, A.J.1
  • 206
    • 0030855393 scopus 로고    scopus 로고
    • Coexpression of lymphoid and myeloid markers on cell surfaces
    • Lefterova P, Schmidt-Wolf IG. Coexpression of lymphoid and myeloid markers on cell surfaces. Leuk Lymphoma 1997; 26: 27-33.
    • (1997) Leuk Lymphoma , vol.26 , pp. 27-33
    • Lefterova, P.1    Schmidt-Wolf, I.G.2
  • 207
    • 0032425963 scopus 로고    scopus 로고
    • Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential
    • Lacaud G, Carlsson L, Keller G. Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential. Immunity 1998; 9: 827-38.
    • (1998) Immunity , vol.9 , pp. 827-838
    • Lacaud, G.1    Carlsson, L.2    Keller, G.3
  • 208
    • 0029837429 scopus 로고    scopus 로고
    • Cytokine regulation of early lymphohematopoietic development
    • Hirayama F, Ogawa M. Cytokine regulation of early lymphohematopoietic development. Stem Cells 1996; 14: 369-75.
    • (1996) Stem Cells , vol.14 , pp. 369-375
    • Hirayama, F.1    Ogawa, M.2
  • 209
    • 0032599946 scopus 로고    scopus 로고
    • Stochastic model revisited
    • Ogawa M. Stochastic model revisited. Int J Hematol 1999; 69: 2-5.
    • (1999) Int J Hematol , vol.69 , pp. 2-5
    • Ogawa, M.1
  • 210
    • 34249683266 scopus 로고    scopus 로고
    • Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges
    • Buza-Vidas N, Luc S, Jacobsen SE. Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges. Curr Opin Hematol 2007; 14: 315-21.
    • (2007) Curr Opin Hematol , vol.14 , pp. 315-321
    • Buza-Vidas, N.1    Luc, S.2    Jacobsen, S.E.3
  • 211
    • 0025350049 scopus 로고
    • Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily
    • Goodwin RG, Friend D, Ziegler SF et al. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 1990; 60: 941-51.
    • (1990) Cell , vol.60 , pp. 941-951
    • Goodwin, R.G.1    Friend, D.2    Ziegler, S.F.3
  • 212
    • 0027731604 scopus 로고
    • Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4
    • Kondo M, Takeshita T, Ishii N et al. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science 1993; 262: 1874-7.
    • (1993) Science , vol.262 , pp. 1874-1877
    • Kondo, M.1    Takeshita, T.2    Ishii, N.3
  • 213
    • 0027988545 scopus 로고
    • Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    • Peschon JJ, Morrissey PJ, Grabstein KH et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994; 180: 1955-60.
    • (1994) J Exp Med , vol.180 , pp. 1955-1960
    • Peschon, J.J.1    Morrissey, P.J.2    Grabstein, K.H.3
  • 214
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    • von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995; 181: 1519-26.
    • (1995) J Exp Med , vol.181 , pp. 1519-1526
    • von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Burdach, S.E.5    Murray, R.6
  • 215
    • 0028925778 scopus 로고
    • Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
    • Cao X, Shores EW, Hu-Li J et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 1995; 2: 223-38.
    • (1995) Immunity , vol.2 , pp. 223-238
    • Cao, X.1    Shores, E.W.2    Hu-Li, J.3
  • 216
    • 0028009181 scopus 로고
    • Interleukin-2 (IL-2) receptor gamma chain mutations in X-linked severe combined immunodeficiency disease result in the loss of high-affinity IL-2 receptor binding
    • DiSanto JP, Dautry-Varsat A, Certain S, Fischer A, de Saint Basile G. Interleukin-2 (IL-2) receptor gamma chain mutations in X-linked severe combined immunodeficiency disease result in the loss of high-affinity IL-2 receptor binding. Eur J Immunol 1994; 24: 475-9.
    • (1994) Eur J Immunol , vol.24 , pp. 475-479
    • DiSanto, J.P.1    Dautry-Varsat, A.2    Certain, S.3    Fischer, A.4    de Saint Basile, G.5
  • 217
    • 13344282747 scopus 로고    scopus 로고
    • Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain
    • Ohbo K, Suda T, Hashiyama M et al. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. Blood 1996; 87: 956-67.
    • (1996) Blood , vol.87 , pp. 956-967
    • Ohbo, K.1    Suda, T.2    Hashiyama, M.3
  • 218
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce JP, Boone DL, Chai S et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998; 9: 669-76.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3
  • 219
    • 0032510062 scopus 로고    scopus 로고
    • Requirement for IRF-1 in the microenvironment supporting development of natural killer cells
    • Ogasawara K, Hida S, Azimi N et al. Requirement for IRF-1 in the microenvironment supporting development of natural killer cells. Nature 1998; 391: 700-3.
    • (1998) Nature , vol.391 , pp. 700-703
    • Ogasawara, K.1    Hida, S.2    Azimi, N.3
  • 220
    • 0031051547 scopus 로고    scopus 로고
    • Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain
    • Suzuki H, Duncan GS, Takimoto H, Mak TW. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J Exp Med 1997; 185: 499-505.
    • (1997) J Exp Med , vol.185 , pp. 499-505
    • Suzuki, H.1    Duncan, G.S.2    Takimoto, H.3    Mak, T.W.4
  • 221
    • 0027993022 scopus 로고
    • Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
    • Miyazaki T, Kawahara A, Fujii H et al. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 1994; 266: 1045-7.
    • (1994) Science , vol.266 , pp. 1045-1047
    • Miyazaki, T.1    Kawahara, A.2    Fujii, H.3
  • 222
    • 0028171065 scopus 로고
    • Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID
    • Russell SM, Johnston JA, Noguchi M et al. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science 1994; 266: 1042-5.
    • (1994) Science , vol.266 , pp. 1042-1045
    • Russell, S.M.1    Johnston, J.A.2    Noguchi, M.3
  • 223
    • 0029550822 scopus 로고
    • Developmental defects of lymphoid cells in Jak3 kinasedeficient mice
    • Park SY, Saijo K, Takahashi T et al. Developmental defects of lymphoid cells in Jak3 kinasedeficient mice. Immunity 1995; 3: 771-82.
    • (1995) Immunity , vol.3 , pp. 771-782
    • Park, S.Y.1    Saijo, K.2    Takahashi, T.3
  • 224
    • 0028840706 scopus 로고
    • Defective lymphoid development in mice lacking Jak3
    • Nosaka T, van Deursen JM, Tripp RA et al. Defective lymphoid development in mice lacking Jak3. Science 1995; 270: 800-2.
    • (1995) Science , vol.270 , pp. 800-802
    • Nosaka, T.1    van Deursen, J.M.2    Tripp, R.A.3
  • 225
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995; 270: 794-7.
    • (1995) Science , vol.270 , pp. 794-797
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 226
    • 0029164841 scopus 로고
    • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi P, Villa A, Giliani S et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995; 377: 65-8.
    • (1995) Nature , vol.377 , pp. 65-68
    • Macchi, P.1    Villa, A.2    Giliani, S.3
  • 227
    • 0028857954 scopus 로고
    • Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development
    • Russell SM, Tayebi N, Nakajima H et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995; 270: 797-800.
    • (1995) Science , vol.270 , pp. 797-800
    • Russell, S.M.1    Tayebi, N.2    Nakajima, H.3
  • 228
    • 0031757825 scopus 로고    scopus 로고
    • Role of interleukin-7 in T-cell development from hematopoietic stem cells
    • Akashi K, Kondo M, Weissman IL. Role of interleukin-7 in T-cell development from hematopoietic stem cells. Immunol Rev 1998; 165: 13-28.
    • (1998) Immunol Rev , vol.165 , pp. 13-28
    • Akashi, K.1    Kondo, M.2    Weissman, I.L.3
  • 229
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988; 335: 440-2.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 230
    • 0031587826 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    • Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, Weissman IL. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 1997; 89: 1033-41.
    • (1997) Cell , vol.89 , pp. 1033-1041
    • Akashi, K.1    Kondo, M.2    von Freeden-Jeffry, U.3    Murray, R.4    Weissman, I.L.5
  • 231
    • 0031587875 scopus 로고    scopus 로고
    • Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/-mice
    • Maraskovsky E, O'Reilly LA, Teepe M, Corcoran LM, Peschon JJ, Strasser A. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/-mice. Cell 1997; 89: 1011-19.
    • (1997) Cell , vol.89 , pp. 1011-1019
    • Maraskovsky, E.1    O'Reilly, L.A.2    Teepe, M.3    Corcoran, L.M.4    Peschon, J.J.5    Strasser, A.6
  • 232
    • 0033553620 scopus 로고    scopus 로고
    • Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death
    • Pestano GA, Zhou Y, Trimble LA, Daley J, Weber GF, Cantor H. Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death. Science 1999; 284: 1187-91.
    • (1999) Science , vol.284 , pp. 1187-1191
    • Pestano, G.A.1    Zhou, Y.2    Trimble, L.A.3    Daley, J.4    Weber, G.F.5    Cantor, H.6
  • 233
    • 0029983731 scopus 로고    scopus 로고
    • The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis
    • Corcoran AE, Smart FM, Cowling RJ, Crompton T, Owen MJ, Venkitaraman AR. The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. Embo J 1996; 15: 1924-32.
    • (1996) Embo J , vol.15 , pp. 1924-1932
    • Corcoran, A.E.1    Smart, F.M.2    Cowling, R.J.3    Crompton, T.4    Owen, M.J.5    Venkitaraman, A.R.6
  • 234
    • 0032567938 scopus 로고    scopus 로고
    • Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
    • Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature 1998; 391: 904-7.
    • (1998) Nature , vol.391 , pp. 904-907
    • Corcoran, A.E.1    Riddell, A.2    Krooshoop, D.3    Venkitaraman, A.R.4
  • 235
    • 0033180184 scopus 로고    scopus 로고
    • Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor
    • Ye SK, Maki K, Kitamura T et al. Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity 1999; 11: 213-23.
    • (1999) Immunity , vol.11 , pp. 213-223
    • Ye, S.K.1    Maki, K.2    Kitamura, T.3
  • 236
    • 0035652459 scopus 로고    scopus 로고
    • The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation
    • Ye SK, Agata Y, Lee HC et al. The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation. Immunity 2001; 15: 813-23.
    • (2001) Immunity , vol.15 , pp. 813-823
    • Ye, S.K.1    Agata, Y.2    Lee, H.C.3
  • 237
    • 0042662868 scopus 로고    scopus 로고
    • Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloidcommitted progenitors to Flt3+ dendritic cells in vivo
    • Karsunky H, Merad M, Cozzio A, Weissman IL, Manz MG. Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloidcommitted progenitors to Flt3+ dendritic cells in vivo. J Exp Med 2003; 198: 305-13.
    • (2003) J Exp Med , vol.198 , pp. 305-313
    • Karsunky, H.1    Merad, M.2    Cozzio, A.3    Weissman, I.L.4    Manz, M.G.5
  • 238
    • 33746208874 scopus 로고    scopus 로고
    • New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors
    • Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegue E. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Cell 2006; 126: 415-26.
    • (2006) Cell , vol.126 , pp. 415-426
    • Forsberg, E.C.1    Serwold, T.2    Kogan, S.3    Weissman, I.L.4    Passegue, E.5
  • 239
    • 0019428880 scopus 로고
    • B220: a B cell-specific member of the T200 glycoprotein family
    • Coffman RL, Weissman IL. B220: a B cell-specific member of the T200 glycoprotein family. Nature 1981; 289: 681-3.
    • (1981) Nature , vol.289 , pp. 681-683
    • Coffman, R.L.1    Weissman, I.L.2
  • 240
    • 0024398742 scopus 로고
    • The early B lineage antigen BP-1 and the transformation-associated antigen 6C3 are on the same molecule
    • Wu Q, Tidmarsh GF, Welch PA, Pierce JH, Weissman IL, Cooper MD. The early B lineage antigen BP-1 and the transformation-associated antigen 6C3 are on the same molecule. J Immunol 1989; 143: 3303-8.
    • (1989) J Immunol , vol.143 , pp. 3303-3308
    • Wu, Q.1    Tidmarsh, G.F.2    Welch, P.A.3    Pierce, J.H.4    Weissman, I.L.5    Cooper, M.D.6
  • 241
    • 0025313754 scopus 로고
    • The growth factor IL-7 induces expression of a transformation-associated antigen in normal pre-B cells
    • Sherwood PJ, Weissman IL. The growth factor IL-7 induces expression of a transformation-associated antigen in normal pre-B cells. Int Immunol 1990; 2: 399-406.
    • (1990) Int Immunol , vol.2 , pp. 399-406
    • Sherwood, P.J.1    Weissman, I.L.2
  • 242
    • 0033557290 scopus 로고    scopus 로고
    • Commitment to the B lymphoid lineage occurs before DH-JH recombination
    • Allman D, Li J, Hardy RR. Commitment to the B lymphoid lineage occurs before DH-JH recombination. J Exp Med 1999; 189: 735-40.
    • (1999) J Exp Med , vol.189 , pp. 735-740
    • Allman, D.1    Li, J.2    Hardy, R.R.3
  • 243
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med 1991; 173: 1213-25.
    • (1991) J Exp Med , vol.173 , pp. 1213-1225
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5
  • 244
    • 0030483542 scopus 로고    scopus 로고
    • Identification of the earliest B lineage stage in mouse bone marrow
    • Li YS, Wasserman R, Hayakawa K, Hardy RR. Identification of the earliest B lineage stage in mouse bone marrow. Immunity 1996; 5: 527-35.
    • (1996) Immunity , vol.5 , pp. 527-535
    • Li, Y.S.1    Wasserman, R.2    Hayakawa, K.3    Hardy, R.R.4
  • 245
    • 0942268731 scopus 로고    scopus 로고
    • Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells
    • Hardy RR, Wei CJ, Hayakawa K. Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells. Immunol Rev 2004; 197: 60-74.
    • (2004) Immunol Rev , vol.197 , pp. 60-74
    • Hardy, R.R.1    Wei, C.J.2    Hayakawa, K.3
  • 246
    • 0035284739 scopus 로고    scopus 로고
    • Phenotypic distinction and functional characterization of pro-B cells in adult mouse bone marrow
    • Mojica MP, Perry SS, Searles AE et al. Phenotypic distinction and functional characterization of pro-B cells in adult mouse bone marrow. J Immunol 2001; 166: 3042-51.
    • (2001) J Immunol , vol.166 , pp. 3042-3051
    • Mojica, M.P.1    Perry, S.S.2    Searles, A.E.3
  • 247
    • 0036204334 scopus 로고    scopus 로고
    • A subfraction of B220(+) cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics
    • Nikolic T, Dingjan GM, Leenen PJ, Hendriks RW. A subfraction of B220(+) cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics. Eur J Immunol 2002; 32: 686-92.
    • (2002) Eur J Immunol , vol.32 , pp. 686-692
    • Nikolic, T.1    Dingjan, G.M.2    Leenen, P.J.3    Hendriks, R.W.4
  • 248
    • 0034053013 scopus 로고    scopus 로고
    • Identification of CD19(-)B220(+)c-Kit(+)Flt3/Flk-2(+)cells as early B lymphoid precursors before pre-B-I cells in juvenile mouse bone marrow
    • Ogawa M, ten Boekel E, Melchers F. Identification of CD19(-)B220(+)c-Kit(+)Flt3/Flk-2(+)cells as early B lymphoid precursors before pre-B-I cells in juvenile mouse bone marrow. Int Immunol 2000; 12: 313-24.
    • (2000) Int Immunol , vol.12 , pp. 313-324
    • Ogawa, M.1    ten Boekel, E.2    Melchers, F.3
  • 249
    • 0028027360 scopus 로고
    • IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development
    • Rolink A, Grawunder U, Winkler TH, Karasuyama H, Melchers F. IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int Immunol 1994; 6: 1257-64.
    • (1994) Int Immunol , vol.6 , pp. 1257-1264
    • Rolink, A.1    Grawunder, U.2    Winkler, T.H.3    Karasuyama, H.4    Melchers, F.5
  • 250
    • 33645081733 scopus 로고    scopus 로고
    • Lineage specification and plasticity in CD19-early B cell precursors
    • Rumfelt LL, Zhou Y, Rowley BM, Shinton SA, Hardy RR. Lineage specification and plasticity in CD19-early B cell precursors. J Exp Med 2006; 203: 675-87.
    • (2006) J Exp Med , vol.203 , pp. 675-687
    • Rumfelt, L.L.1    Zhou, Y.2    Rowley, B.M.3    Shinton, S.A.4    Hardy, R.R.5
  • 251
    • 33646587068 scopus 로고    scopus 로고
    • Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse
    • Tung JW, Mrazek MD, Yang Y, Herzenberg LA. Phenotypically distinct B cell development pathways map to the three B cell lineages in the mouse. Proc Natl Acad Sci U S A 2006; 103: 6293-8.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6293-6298
    • Tung, J.W.1    Mrazek, M.D.2    Yang, Y.3    Herzenberg, L.A.4
  • 252
    • 0033711666 scopus 로고    scopus 로고
    • Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events
    • Tudor KS, Payne KJ, Yamashita Y, Kincade PW. Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events. Immunity 2000; 12: 335-45.
    • (2000) Immunity , vol.12 , pp. 335-345
    • Tudor, K.S.1    Payne, K.J.2    Yamashita, Y.3    Kincade, P.W.4
  • 255
    • 0027153201 scopus 로고
    • A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
    • Godfrey DI, Kennedy J, Suda T, Zlotnik A. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8-triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol 1993; 150: 4244-52.
    • (1993) J Immunol , vol.150 , pp. 4244-4252
    • Godfrey, D.I.1    Kennedy, J.2    Suda, T.3    Zlotnik, A.4
  • 256
    • 0027305022 scopus 로고
    • Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation
    • Matsuzaki Y, Gyotoku J, Ogawa M et al. Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation. J Exp Med 1993; 178: 1283-92.
    • (1993) J Exp Med , vol.178 , pp. 1283-1292
    • Matsuzaki, Y.1    Gyotoku, J.2    Ogawa, M.3
  • 257
    • 0026085993 scopus 로고
    • CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus
    • Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature 1991; 349: 71-4.
    • (1991) Nature , vol.349 , pp. 71-74
    • Wu, L.1    Scollay, R.2    Egerton, M.3    Pearse, M.4    Spangrude, G.J.5    Shortman, K.6
  • 258
    • 0027205082 scopus 로고
    • Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population
    • Ardavin C, Wu L, Li CL, Shortman K. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 1993; 362: 761-3.
    • (1993) Nature , vol.362 , pp. 761-763
    • Ardavin, C.1    Wu, L.2    Li, C.L.3    Shortman, K.4
  • 259
    • 0028335847 scopus 로고
    • Thymic stem cells in mouse bone marrow
    • Antica M, Wu L, Shortman K, Scollay R. Thymic stem cells in mouse bone marrow. Blood 1994; 84: 111-17.
    • (1994) Blood , vol.84 , pp. 111-117
    • Antica, M.1    Wu, L.2    Shortman, K.3    Scollay, R.4
  • 260
    • 0037320932 scopus 로고    scopus 로고
    • Thymopoiesis independent of common lymphoid progenitors
    • Allman D, Sambandam A, Kim S et al. Thymopoiesis independent of common lymphoid progenitors. Nat Immunol 2003; 4: 168-74.
    • (2003) Nat Immunol , vol.4 , pp. 168-174
    • Allman, D.1    Sambandam, A.2    Kim, S.3
  • 261
    • 33645060484 scopus 로고    scopus 로고
    • T-cell development: an extrathymic perspective
    • Blais ME, Louis I, Perreault C. T-cell development: an extrathymic perspective. Immunol Rev 2006; 209: 103-14.
    • (2006) Immunol Rev , vol.209 , pp. 103-114
    • Blais, M.E.1    Louis, I.2    Perreault, C.3
  • 263
    • 2642712488 scopus 로고    scopus 로고
    • An alternate pathway for T cell development supported by the bone marrow microenvironment: recapitulation of thymic maturation
    • Garcia-Ojeda ME, Dejbakhsh-Jones S, Weissman IL, Strober S. An alternate pathway for T cell development supported by the bone marrow microenvironment: recapitulation of thymic maturation. J Exp Med 1998; 187: 1813-23.
    • (1998) J Exp Med , vol.187 , pp. 1813-1823
    • Garcia-Ojeda, M.E.1    Dejbakhsh-Jones, S.2    Weissman, I.L.3    Strober, S.4
  • 264
    • 47049088149 scopus 로고    scopus 로고
    • Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages
    • Epub 2008 April 18. doi: 10.1182/blood-2007-11-126219
    • Karsunky H, Inlay MA, Serwold T, Bhattacharya D, Weissman IL. Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages. Blood. Epub 2008 April 18. doi: 10.1182/blood-2007-11-126219.
    • Blood.
    • Karsunky, H.1    Inlay, M.A.2    Serwold, T.3    Bhattacharya, D.4    Weissman, I.L.5
  • 265
    • 0037818716 scopus 로고    scopus 로고
    • Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation
    • Arber C, BitMansour A, Sparer TE et al. Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation. Blood 2003; 102: 421-8.
    • (2003) Blood , vol.102 , pp. 421-428
    • Arber, C.1    BitMansour, A.2    Sparer, T.E.3
  • 266
  • 267
    • 0025801106 scopus 로고
    • Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells
    • Gore SD, Kastan MB, Civin CI. Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells. Blood 1991; 77: 1681-90.
    • (1991) Blood , vol.77 , pp. 1681-1690
    • Gore, S.D.1    Kastan, M.B.2    Civin, C.I.3
  • 268
    • 0034234756 scopus 로고    scopus 로고
    • Fates of human B-cell precursors
    • LeBien TW. Fates of human B-cell precursors. Blood 2000; 96: 9-23.
    • (2000) Blood , vol.96 , pp. 9-23
    • LeBien, T.W.1
  • 269
    • 0028784287 scopus 로고
    • Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset
    • Galy A, Travis M, Cen D, Chen B. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 1995; 3: 459-73.
    • (1995) Immunity , vol.3 , pp. 459-473
    • Galy, A.1    Travis, M.2    Cen, D.3    Chen, B.4
  • 270
    • 0029812552 scopus 로고    scopus 로고
    • Interleukin 7 independent development of human B cells
    • Prieyl JA, LeBien TW. Interleukin 7 independent development of human B cells. Proc Natl Acad Sci U S A 1996; 93: 10348-53.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 10348-53
    • Prieyl, J.A.1    LeBien, T.W.2
  • 271
    • 0031740732 scopus 로고    scopus 로고
    • Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
    • Puel A, Ziegler SF, Buckley RH, Leonard WJ. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat Genet 1998; 20: 394-7.
    • (1998) Nat Genet , vol.20 , pp. 394-397
    • Puel, A.1    Ziegler, S.F.2    Buckley, R.H.3    Leonard, W.J.4
  • 272
    • 0034667634 scopus 로고    scopus 로고
    • A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency
    • Roifman CM, Zhang J, Chitayat D, Sharfe N. A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. Blood 2000; 96: 2803-7.
    • (2000) Blood , vol.96 , pp. 2803-2807
    • Roifman, C.M.1    Zhang, J.2    Chitayat, D.3    Sharfe, N.4
  • 274
    • 0028878890 scopus 로고
    • The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34
    • Dittel BN, LeBien TW. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34. J Immunol 1995; 154: 58-67.
    • (1995) J Immunol , vol.154 , pp. 58-67
    • Dittel, B.N.1    LeBien, T.W.2
  • 275
    • 0031786671 scopus 로고    scopus 로고
    • Early stages in the development of human T, natural killer and thymic dendritic cells
    • Spits H, Blom B, Jaleco AC et al. Early stages in the development of human T, natural killer and thymic dendritic cells. Immunol Rev 1998; 165: 75-86.
    • (1998) Immunol Rev , vol.165 , pp. 75-86
    • Spits, H.1    Blom, B.2    Jaleco, A.C.3
  • 276
    • 34848883146 scopus 로고    scopus 로고
    • Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
    • Arinobu Y, Mizuno SI, Chong Y et al. Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 2007; 1: 416-27.
    • (2007) Cell Stem Cell , vol.1 , pp. 416-427
    • Arinobu, Y.1    Mizuno, S.I.2    Chong, Y.3
  • 277
    • 0018756315 scopus 로고
    • CFU-S in individual erythroid colonies derived in vitro from adult mouse marrow
    • Humphries RK, Jacky PB, Dill FJ, Eaves AC, Eaves CJ. CFU-S in individual erythroid colonies derived in vitro from adult mouse marrow. Nature 1979; 279: 718-20.
    • (1979) Nature , vol.279 , pp. 718-720
    • Humphries, R.K.1    Jacky, P.B.2    Dill, F.J.3    Eaves, A.C.4    Eaves, C.J.5
  • 278
    • 0037422537 scopus 로고    scopus 로고
    • Characterization of mouse clonogenic megakaryocyte progenitors
    • Nakorn TN, Miyamoto T, Weissman IL. Characterization of mouse clonogenic megakaryocyte progenitors. Proc Natl Acad Sci U S A 2003; 100: 205-10.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 205-210
    • Nakorn, T.N.1    Miyamoto, T.2    Weissman, I.L.3
  • 279
    • 13244277736 scopus 로고    scopus 로고
    • Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
    • Nutt SL, Metcalf D, D'Amico A, Polli M, Wu L. Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med 2005; 201: 221-31.
    • (2005) J Exp Med , vol.201 , pp. 221-231
    • Nutt, S.L.1    Metcalf, D.2    D'Amico, A.3    Polli, M.4    Wu, L.5
  • 280
    • 34848896359 scopus 로고    scopus 로고
    • Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
    • Pronk CJH, Rossi D, ManssonR et al. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell 2007; 1: 428-42.
    • (2007) Cell Stem Cell , vol.1 , pp. 428-442
    • Pronk, C.J.H.1    Rossi, D.2    Mansson, R.3
  • 281
    • 20244387299 scopus 로고    scopus 로고
    • Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential: a revised road map for adult blood lineage commitment
    • Adolfsson J, Mansson R, Buza-Vidas N et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential: a revised road map for adult blood lineage commitment. Cell 2005; 121: 295-306.
    • (2005) Cell , vol.121 , pp. 295-306
    • Adolfsson, J.1    Mansson, R.2    Buza-Vidas, N.3
  • 282
    • 34848823741 scopus 로고    scopus 로고
    • Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models
    • DeKoter RP, Kamath MB, Houston IB. Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models. Blood Cells Mol Dis 2007; 39: 316-20.
    • (2007) Blood Cells Mol Dis , vol.39 , pp. 316-320
    • DeKoter, R.P.1    Kamath, M.B.2    Houston, I.B.3
  • 283
    • 0025524734 scopus 로고
    • Conversion of normal Ly-1-positive B-lineage cells into Ly-1-positive macrophages in long-term bone marrow cultures
    • Katoh S, Tominaga A, Migita M, Kudo A, Takatsu K. Conversion of normal Ly-1-positive B-lineage cells into Ly-1-positive macrophages in long-term bone marrow cultures. Dev Immunol 1990; 1: 113-25.
    • (1990) Dev Immunol , vol.1 , pp. 113-125
    • Katoh, S.1    Tominaga, A.2    Migita, M.3    Kudo, A.4    Takatsu, K.5
  • 284
    • 0023946242 scopus 로고
    • Hemopoietic lineage switch: v-raf oncogene converts Emu-myc transgenic B cells into macrophages
    • Klinken SP, Alexander WS, Adams JM. Hemopoietic lineage switch: v-raf oncogene converts Emu-myc transgenic B cells into macrophages. Cell 1988; 53: 857-67.
    • (1988) Cell , vol.53 , pp. 857-867
    • Klinken, S.P.1    Alexander, W.S.2    Adams, J.M.3
  • 285
    • 0027166745 scopus 로고
    • A novel cellular model (SPGM 1) of switching between the pre-B cell and myelomonocytic lineages
    • Martin M, Strasser A, Baumgarth N et al. A novel cellular model (SPGM 1) of switching between the pre-B cell and myelomonocytic lineages. J Immunol 1993; 150: 4395-406.
    • (1993) J Immunol , vol.150 , pp. 4395-4406
    • Martin, M.1    Strasser, A.2    Baumgarth, N.3
  • 286
    • 0034699390 scopus 로고    scopus 로고
    • Cellfate conversion of lymphoid-committed progenitors by instructive actions of cytokines
    • Kondo M, Scherer DC, Miyamoto T et al. Cellfate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Nature 2000; 407: 383-6.
    • (2000) Nature , vol.407 , pp. 383-386
    • Kondo, M.1    Scherer, D.C.2    Miyamoto, T.3
  • 287
    • 31444431706 scopus 로고    scopus 로고
    • Antagonistic effect of CCAAT enhance-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors
    • Hsu C-L, King-Fleischman AG, Lai AY et al. Antagonistic effect of CCAAT enhance-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Proc Natl Acad Sci U S A 2006; 103: 672-7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 672-677
    • Hsu, C.-L.1    King-Fleischman, A.G.2    Lai, A.Y.3
  • 288
    • 0026561448 scopus 로고
    • Bipotential precursors of B cells and macrophages in murine fetal liver
    • Cumano A, Paige CJ, Iscove NN, Brady G. Bipotential precursors of B cells and macrophages in murine fetal liver. Nature 1992; 356: 612-15.
    • (1992) Nature , vol.356 , pp. 612-615
    • Cumano, A.1    Paige, C.J.2    Iscove, N.N.3    Brady, G.4
  • 289
    • 0030962093 scopus 로고    scopus 로고
    • Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver
    • Kawamoto H, Ohmura K, Katsura Y. Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver. Int Immunol 1997; 9: 1011-19.
    • (1997) Int Immunol , vol.9 , pp. 1011-1019
    • Kawamoto, H.1    Ohmura, K.2    Katsura, Y.3
  • 290
    • 0035337478 scopus 로고    scopus 로고
    • The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3-cells, as well as macrophages
    • Mebius RE, Miyamoto T, Christensen J et al. The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3-cells, as well as macrophages. J Immunol 2001; 166: 6593-601.
    • (2001) J Immunol , vol.166 , pp. 6593-6601
    • Mebius, R.E.1    Miyamoto, T.2    Christensen, J.3
  • 291
    • 0035230221 scopus 로고    scopus 로고
    • Bipotential B-macrophage progenitors are present in adult bone marrow
    • Montecino-Rodriguez E, Leathers H, Dorshkind K. Bipotential B-macrophage progenitors are present in adult bone marrow. Nat Immunol 2001; 2: 83-8.
    • (2001) Nat Immunol , vol.2 , pp. 83-88
    • Montecino-Rodriguez, E.1    Leathers, H.2    Dorshkind, K.3
  • 292
    • 0027299733 scopus 로고
    • Rapid discrimination of early CD34+ myeloid progenitors using CD45-RA analysis
    • Fritsch G, Buchinger, Printz D et al. Rapid discrimination of early CD34+ myeloid progenitors using CD45-RA analysis. Blood 1993; 81: 2301-9.
    • (1993) Blood , vol.81 , pp. 2301-2309
    • Fritsch, G.1    Buchinger Printz, D.2
  • 293
    • 0032722187 scopus 로고    scopus 로고
    • Correlation between IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues
    • Huang S, Chen Z, Yu JF et al. Correlation between IL-3 receptor expression and growth potential of human CD34+ hematopoietic cells from different tissues. Stem Cells 1999; 17: 265-72.
    • (1999) Stem Cells , vol.17 , pp. 265-272
    • Huang, S.1    Chen, Z.2    Yu, J.F.3
  • 294
    • 0025358537 scopus 로고
    • Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow
    • Lansdorp PM, Sutherland HJ, Eaves CJ. Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow. J Exp Med 1990; 172: 363-6.
    • (1990) J Exp Med , vol.172 , pp. 363-366
    • Lansdorp, P.M.1    Sutherland, H.J.2    Eaves, C.J.3
  • 295
    • 0034851486 scopus 로고    scopus 로고
    • CCR1 chemokine receptor expression isolates erythroid from granulocyte-macrophage progenitors
    • de Wynter EA, Heyworth CM, Mukaida N et al. CCR1 chemokine receptor expression isolates erythroid from granulocyte-macrophage progenitors. J Leukoc Biol 2001; 70: 455-60.
    • (2001) J Leukoc Biol , vol.70 , pp. 455-460
    • de Wynter, E.A.1    Heyworth, C.M.2    Mukaida, N.3
  • 296
    • 18344418672 scopus 로고    scopus 로고
    • Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase
    • Rappold I, Ziegler BL, Kohler I et al. Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. Blood 1997; 90: 111-25.
    • (1997) Blood , vol.90 , pp. 111-125
    • Rappold, I.1    Ziegler, B.L.2    Kohler, I.3
  • 297
    • 0035905767 scopus 로고    scopus 로고
    • CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
    • Irie-Sasaki J, Sasaki T, Matsumoto W et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 2001; 409: 349-54.
    • (2001) Nature , vol.409 , pp. 349-354
    • Irie-Sasaki, J.1    Sasaki, T.2    Matsumoto, W.3
  • 298
    • 0027325195 scopus 로고
    • Differentiation and proliferation of hematopoietic stem cells
    • Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993; 81: 2844-53.
    • (1993) Blood , vol.81 , pp. 2844-2853
    • Ogawa, M.1
  • 299
    • 0031467607 scopus 로고    scopus 로고
    • Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors
    • Kimura T, Sakabe H, Tanimukai S et al. Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors. Blood 1997; 90: 4767-78.
    • (1997) Blood , vol.90 , pp. 4767-4778
    • Kimura, T.1    Sakabe, H.2    Tanimukai, S.3
  • 300
    • 0032875612 scopus 로고    scopus 로고
    • Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow
    • Holyoake TL, Nicolini FE, Eaves CJ. Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow. Exp Hematol 1999; 27: 1418-27.
    • (1999) Exp Hematol , vol.27 , pp. 1418-1427
    • Holyoake, T.L.1    Nicolini, F.E.2    Eaves, C.J.3
  • 302
    • 0029909363 scopus 로고    scopus 로고
    • Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo
    • Pawliuk R, Eaves C, Humphries RK. Evidence of both ontogeny and transplant dose-regulated expansion of hematopoietic stem cells in vivo. Blood 1996; 88: 2852-8.
    • (1996) Blood , vol.88 , pp. 2852-2858
    • Pawliuk, R.1    Eaves, C.2    Humphries, R.K.3
  • 303
    • 0034053443 scopus 로고    scopus 로고
    • Development and function of B-1 cells
    • Hayakawa K, Hardy RR. Development and function of B-1 cells. Curr Opin Immunol 2000; 12: 346-53.
    • (2000) Curr Opin Immunol , vol.12 , pp. 346-353
    • Hayakawa, K.1    Hardy, R.R.2
  • 304
    • 0035437127 scopus 로고    scopus 로고
    • Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets
    • Traver D, Miyamoto T, Christensen J, Iwasaki-Arai J, Akashi K, Weissman IL. Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets. Blood 2001; 98: 627-35.
    • (2001) Blood , vol.98 , pp. 627-635
    • Traver, D.1    Miyamoto, T.2    Christensen, J.3    Iwasaki-Arai, J.4    Akashi, K.5    Weissman, I.L.6
  • 305
    • 0030888660 scopus 로고    scopus 로고
    • Three distinctive steps in Peyer's patch formation of murine embryo
    • Adachi S, Yoshida H, Kataoka H, Nishikawa S. Three distinctive steps in Peyer's patch formation of murine embryo. Int Immunol 1997; 9: 507-14.
    • (1997) Int Immunol , vol.9 , pp. 507-514
    • Adachi, S.1    Yoshida, H.2    Kataoka, H.3    Nishikawa, S.4
  • 306
    • 0031038031 scopus 로고    scopus 로고
    • Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
    • Nutt SL, Urbanek P, Rolink A, Busslinger M. Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus. Genes Dev 1997; 11: 476-91.
    • (1997) Genes Dev , vol.11 , pp. 476-491
    • Nutt, S.L.1    Urbanek, P.2    Rolink, A.3    Busslinger, M.4
  • 307
    • 0029744338 scopus 로고    scopus 로고
    • A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3-cells to colonize lymph nodes
    • Mebius RE, Streeter PR, Michie S, Butcher EC, Weissman IL. A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3-cells to colonize lymph nodes. Proc Natl Acad Sci U S A 1996; 93: 11019-24.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11019-11024
    • Mebius, R.E.1    Streeter, P.R.2    Michie, S.3    Butcher, E.C.4    Weissman, I.L.5
  • 308
    • 0030710079 scopus 로고    scopus 로고
    • Developing lymph nodes collect CD4+CD3-LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
    • Mebius RE, Rennert P, Weissman IL. Developing lymph nodes collect CD4+CD3-LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 1997; 7: 493-504.
    • (1997) Immunity , vol.7 , pp. 493-504
    • Mebius, R.E.1    Rennert, P.2    Weissman, I.L.3
  • 309
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245-52.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 310
    • 0030781916 scopus 로고    scopus 로고
    • Dendritic cells: unique leukocyte populations which control the primary immune response
    • Hart DN. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997; 90: 3245-87.
    • (1997) Blood , vol.90 , pp. 3245-3287
    • Hart, D.N.1
  • 311
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9: 271-96.
    • (1991) Annu Rev Immunol , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 312
    • 0034919938 scopus 로고    scopus 로고
    • Dendritic cell lineage, plasticity and cross-regulation
    • Liu YJ, Kanzler H, Soumelis V, Gilliet M. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol 2001; 2: 585-9.
    • (2001) Nat Immunol , vol.2 , pp. 585-589
    • Liu, Y.J.1    Kanzler, H.2    Soumelis, V.3    Gilliet, M.4
  • 313
    • 0036518287 scopus 로고    scopus 로고
    • Mouse and human dendritic cell subtypes
    • Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002; 2: 151-61.
    • (2002) Nat Rev Immunol , vol.2 , pp. 151-161
    • Shortman, K.1    Liu, Y.J.2
  • 314
    • 0026691899 scopus 로고
    • The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells
    • Vremec D, Zorbas M, Scollay R et al. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med 1992; 176: 47-58.
    • (1992) J Exp Med , vol.176 , pp. 47-58
    • Vremec, D.1    Zorbas, M.2    Scollay, R.3
  • 315
    • 0029787979 scopus 로고    scopus 로고
    • Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny
    • Wu L, Li CL, Shortman K. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J Exp Med 1996; 184: 903-11.
    • (1996) J Exp Med , vol.184 , pp. 903-911
    • Wu, L.1    Li, C.L.2    Shortman, K.3
  • 316
    • 0001722505 scopus 로고    scopus 로고
    • RelB is essential for the development of myeloid-related CD8alpha-dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells
    • Wu L, D'Amico A, Winkel KD, Suter M, Lo D, Shortman K. RelB is essential for the development of myeloid-related CD8alpha-dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity 1998; 9: 839-47.
    • (1998) Immunity , vol.9 , pp. 839-847
    • Wu, L.1    D'Amico, A.2    Winkel, K.D.3    Suter, M.4    Lo, D.5    Shortman, K.6
  • 317
    • 0034142238 scopus 로고    scopus 로고
    • PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells
    • Guerriero A, Langmuir PB, Spain LM, Scott EW. PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells. Blood 2000; 95: 879-85.
    • (2000) Blood , vol.95 , pp. 879-885
    • Guerriero, A.1    Langmuir, P.B.2    Spain, L.M.3    Scott, E.W.4
  • 318
    • 0030703546 scopus 로고    scopus 로고
    • Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage
    • Wu L, Nichogiannopoulou A, Shortman K, Georgopoulos K. Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity 1997; 7: 483-92.
    • (1997) Immunity , vol.7 , pp. 483-492
    • Wu, L.1    Nichogiannopoulou, A.2    Shortman, K.3    Georgopoulos, K.4
  • 319
    • 0034599854 scopus 로고    scopus 로고
    • Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells
    • Radtke F, Ferrero I, Wilson A, Lees R, Aguet M, MacDonald HR. Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells. J Exp Med 2000; 191: 1085-94.
    • (2000) J Exp Med , vol.191 , pp. 1085-1094
    • Radtke, F.1    Ferrero, I.2    Wilson, A.3    Lees, R.4    Aguet, M.5    MacDonald, H.R.6
  • 320
    • 0035383775 scopus 로고    scopus 로고
    • Dendritic cell potentials of early lymphoid and myeloid progenitors
    • Manz MG, Traver D, Miyamoto T, Weissman IL, Akashi K. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 2001; 97: 3333-41.
    • (2001) Blood , vol.97 , pp. 3333-3341
    • Manz, M.G.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4    Akashi, K.5
  • 321
    • 0034670385 scopus 로고    scopus 로고
    • Development of CD8alpha-positive dendritic cells from a common myeloid progenitor
    • Traver D, Akashi K, Manz M et al. Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Science 2000; 290: 2152-4.
    • (2000) Science , vol.290 , pp. 2152-2154
    • Traver, D.1    Akashi, K.2    Manz, M.3
  • 322
    • 0035761466 scopus 로고    scopus 로고
    • Development of thymic and splenic dendritic cell populations from different hemopoietic precursors
    • Wu L, D'Amico A, Hochrein H, O'Keeffe M, Shortman K, Lucas K. Development of thymic and splenic dendritic cell populations from different hemopoietic precursors. Blood 2001; 98: 3376-82.
    • (2001) Blood , vol.98 , pp. 3376-3382
    • Wu, L.1    D'Amico, A.2    Hochrein, H.3    O'Keeffe, M.4    Shortman, K.5    Lucas, K.6
  • 323
    • 0035877996 scopus 로고    scopus 로고
    • Identification of a novel, human multilymphoid progenitor in cord blood
    • Hao QL, Zhu J, Price MA, Payne KJ, Barsky LW, Crooks GM. Identification of a novel, human multilymphoid progenitor in cord blood. Blood 2001; 97: 3683-90.
    • (2001) Blood , vol.97 , pp. 3683-3690
    • Hao, Q.L.1    Zhu, J.2    Price, M.A.3    Payne, K.J.4    Barsky, L.W.5    Crooks, G.M.6
  • 324
    • 10144260007 scopus 로고    scopus 로고
    • CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GMCSF+ TNF alpha
    • Caux C, Vanbervliet B, Massacrier C et al. CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GMCSF+ TNF alpha. J Exp Med 1996; 184: 695-706.
    • (1996) J Exp Med , vol.184 , pp. 695-706
    • Caux, C.1    Vanbervliet, B.2    Massacrier, C.3
  • 325
    • 0029162640 scopus 로고
    • Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha
    • Young JW, Szabolcs P, Moore MA. Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. J Exp Med 1995; 182: 1111-19.
    • (1995) J Exp Med , vol.182 , pp. 1111-1119
    • Young, J.W.1    Szabolcs, P.2    Moore, M.A.3
  • 326
    • 0032538522 scopus 로고    scopus 로고
    • Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
    • Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 1998; 282: 480-3.
    • (1998) Science , vol.282 , pp. 480-483
    • Randolph, G.J.1    Beaulieu, S.2    Lebecque, S.3    Steinman, R.M.4    Muller, W.A.5
  • 327
    • 0028285230 scopus 로고
    • Proliferating dendritic cell progenitors in human blood
    • Romani N, Gruner S, Brang D et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994; 180: 83-93.
    • (1994) J Exp Med , vol.180 , pp. 83-93
    • Romani, N.1    Gruner, S.2    Brang, D.3
  • 328
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994; 179: 1109-18.
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 329
    • 0032773794 scopus 로고    scopus 로고
    • Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
    • Cella M, Jarrossay D, Facchetti F et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 1999; 5: 919-23.
    • (1999) Nat Med , vol.5 , pp. 919-923
    • Cella, M.1    Jarrossay, D.2    Facchetti, F.3
  • 330
    • 0030949479 scopus 로고    scopus 로고
    • The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand
    • Grouard G, Rissoan MC, Filgueira L, Durand I, Banchereau J, Liu YJ. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 1997; 185: 1101-11.
    • (1997) J Exp Med , vol.185 , pp. 1101-1111
    • Grouard, G.1    Rissoan, M.C.2    Filgueira, L.3    Durand, I.4    Banchereau, J.5    Liu, Y.J.6
  • 331
    • 0035179882 scopus 로고    scopus 로고
    • Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
    • Jarrossay D, Napolitani G, Colonna M, Sallusto F, Lanzavecchia A. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001; 31: 3388-93.
    • (2001) Eur J Immunol , vol.31 , pp. 3388-3393
    • Jarrossay, D.1    Napolitani, G.2    Colonna, M.3    Sallusto, F.4    Lanzavecchia, A.5
  • 332
    • 0034679566 scopus 로고    scopus 로고
    • Natural interferon alpha/beta-producing cells link innate and adaptive immunity
    • Kadowaki N, Antonenko S, Lau JY, Liu YJ. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med 2000; 192: 219-26.
    • (2000) J Exp Med , vol.192 , pp. 219-226
    • Kadowaki, N.1    Antonenko, S.2    Lau, J.Y.3    Liu, Y.J.4
  • 333
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N, Ho S, Antonenko S et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001; 194: 863-9.
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3
  • 334
    • 0035202483 scopus 로고    scopus 로고
    • Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
    • Asselin-Paturel C, Boonstra A, Dalod M et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2001; 2: 1144-50.
    • (2001) Nat Immunol , vol.2 , pp. 1144-1150
    • Asselin-Paturel, C.1    Boonstra, A.2    Dalod, M.3
  • 335
    • 0035895048 scopus 로고    scopus 로고
    • Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice
    • Bjorck P. Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood 2001; 98: 3520-6.
    • (2001) Blood , vol.98 , pp. 3520-3526
    • Bjorck, P.1
  • 336
    • 33644828391 scopus 로고    scopus 로고
    • Development of dendritic cell system
    • Wu L, Dakic A. Development of dendritic cell system. Cell Mol Immunol 2004; 1: 112-18.
    • (2004) Cell Mol Immunol , vol.1 , pp. 112-118
    • Wu, L.1    Dakic, A.2
  • 337
    • 12844278752 scopus 로고    scopus 로고
    • Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors
    • Karsunky H, Merad M, Mende I, Manz MG, Engleman EG, Weissman IL. Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors. Exp Hematol 2005; 33: 173-81.
    • (2005) Exp Hematol , vol.33 , pp. 173-181
    • Karsunky, H.1    Merad, M.2    Mende, I.3    Manz, M.G.4    Engleman, E.G.5    Weissman, I.L.6
  • 338
    • 0037007023 scopus 로고    scopus 로고
    • Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling
    • King AG, Kondo M, Scherer DC, Weissman IL. Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling. Proc Natl Acad Sci U S A 2002; 99: 4508-13.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 4508-4513
    • King, A.G.1    Kondo, M.2    Scherer, D.C.3    Weissman, I.L.4
  • 339
    • 34250007142 scopus 로고    scopus 로고
    • Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    • Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007; 447: 725-9.
    • (2007) Nature , vol.447 , pp. 725-729
    • Rossi, D.J.1    Bryder, D.2    Seita, J.3    Nussenzweig, A.4    Hoeijmakers, J.5    Weissman, I.L.6
  • 341
    • 17744370294 scopus 로고    scopus 로고
    • A genetic analysis of neural progenitor differentiation
    • Geschwind DH, Ou J, Easterday MC et al. A genetic analysis of neural progenitor differentiation. Neuron 2001; 29: 325-39.
    • (2001) Neuron , vol.29 , pp. 325-339
    • Geschwind, D.H.1    Ou, J.2    Easterday, M.C.3
  • 343
    • 0032190631 scopus 로고    scopus 로고
    • A transcription factor party during blood cell differentiation
    • Sieweke MH, Graf T. A transcription factor party during blood cell differentiation. Curr Opin Genet Dev 1998; 8: 545-51.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 545-551
    • Sieweke, M.H.1    Graf, T.2
  • 344
    • 0034717335 scopus 로고    scopus 로고
    • Regulation of B lymphocyte and macrophage development by graded expression of PU.1
    • DeKoter RP, Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 2000; 288: 1439-41.
    • (2000) Science , vol.288 , pp. 1439-1441
    • DeKoter, R.P.1    Singh, H.2
  • 345
    • 0030954167 scopus 로고    scopus 로고
    • Multilineage gene expression precedes commitment in the hemopoietic system
    • Hu M, Krause D, Greaves M et al. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev 1997; 11: 774-85.
    • (1997) Genes Dev , vol.11 , pp. 774-785
    • Hu, M.1    Krause, D.2    Greaves, M.3
  • 346
    • 0030581174 scopus 로고    scopus 로고
    • The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
    • Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 1996; 86: 47-57.
    • (1996) Cell , vol.86 , pp. 47-57
    • Porcher, C.1    Swat, W.2    Rockwell, K.3    Fujiwara, Y.4    Alt, F.W.5    Orkin, S.H.6
  • 347
    • 0028858855 scopus 로고
    • Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
    • Shivdasani RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 1995; 373: 432-4.
    • (1995) Nature , vol.373 , pp. 432-434
    • Shivdasani, R.A.1    Mayer, E.L.2    Orkin, S.H.3
  • 348
    • 0028022916 scopus 로고
    • An early haematopoietic defect in mice lacking the transcription factor GATA-2
    • Tsai FY, Keller G, Kuo FC et al. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 1994; 371: 221-6.
    • (1994) Nature , vol.371 , pp. 221-226
    • Tsai, F.Y.1    Keller, G.2    Kuo, F.C.3
  • 349
    • 0029926485 scopus 로고    scopus 로고
    • Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
    • Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A 1996; 93: 12355-8.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12355-8
    • Fujiwara, Y.1    Browne, C.P.2    Cunniff, K.3    Goff, S.C.4    Orkin, S.H.5
  • 350
    • 0030926006 scopus 로고    scopus 로고
    • A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet developmnt
    • Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet developmnt. EMBO J 1997; 16: 3965-73.
    • (1997) EMBO J , vol.16 , pp. 3965-3973
    • Shivdasani, R.A.1    Fujiwara, Y.2    McDevitt, M.A.3    Orkin, S.H.4
  • 351
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    • Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A 1997; 94: 569-74.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 569-574
    • Zhang, D.E.1    Zhang, P.2    Wang, N.D.3    Hetherington, C.J.4    Darlington, G.J.5    Tenen, D.G.6
  • 352
    • 0030972497 scopus 로고    scopus 로고
    • Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
    • Morgan B, Sun L, Avitahl N et al. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J 1997; 16: 2004-13.
    • (1997) EMBO J , vol.16 , pp. 2004-2013
    • Morgan, B.1    Sun, L.2    Avitahl, N.3
  • 353
    • 0031907815 scopus 로고    scopus 로고
    • Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
    • Klug CA, Morrison SJ, Masek M, Hahm K, Smale ST, Weissman IL. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Proc Natl Acad Sci U S A 1998; 95: 657-62.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 657-662
    • Klug, C.A.1    Morrison, S.J.2    Masek, M.3    Hahm, K.4    Smale, S.T.5    Weissman, I.L.6
  • 354
    • 0028001362 scopus 로고
    • The Ikaros gene is required for the development of all lymphoid lineages
    • Georgopoulos K, Bigby M, Wang JH et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994; 79: 143-56.
    • (1994) Cell , vol.79 , pp. 143-156
    • Georgopoulos, K.1    Bigby, M.2    Wang, J.H.3
  • 355
    • 0029828994 scopus 로고    scopus 로고
    • Transcription factor GATA-3 is required for development of the T-cell lineage
    • Ting CN, Olson MC, Barton KP, Leiden JM. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 1996; 384: 474-8.
    • (1996) Nature , vol.384 , pp. 474-478
    • Ting, C.N.1    Olson, M.C.2    Barton, K.P.3    Leiden, J.M.4
  • 356
    • 0033533891 scopus 로고    scopus 로고
    • Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
    • Nutt SL, Heavey B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999; 401: 556-62.
    • (1999) Nature , vol.401 , pp. 556-562
    • Nutt, S.L.1    Heavey, B.2    Rolink, A.G.3    Busslinger, M.4
  • 357
    • 0032504051 scopus 로고    scopus 로고
    • Loops, lineage, and leukemia
    • Enver T, Greaves M. Loops, lineage, and leukemia. Cell 1998; 94: 9-12.
    • (1998) Cell , vol.94 , pp. 9-12
    • Enver, T.1    Greaves, M.2
  • 358
    • 0034596309 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells
    • Marks PA, Richon VM, Rifkind RA. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst 2000; 92: 1210-16.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1210-1216
    • Marks, P.A.1    Richon, V.M.2    Rifkind, R.A.3
  • 359
    • 0029870839 scopus 로고    scopus 로고
    • MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation
    • Sieweke MH, Tekotte H, Frampton J, Graf T. MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. Cell 1996; 85: 49-60.
    • (1996) Cell , vol.85 , pp. 49-60
    • Sieweke, M.H.1    Tekotte, H.2    Frampton, J.3    Graf, T.4
  • 360
    • 0034667672 scopus 로고    scopus 로고
    • PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
    • Zhang P, Zhang X, Iwama A et al. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood 2000; 96: 2641-8.
    • (2000) Blood , vol.96 , pp. 2641-2648
    • Zhang, P.1    Zhang, X.2    Iwama, A.3
  • 361
    • 0029066359 scopus 로고
    • GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts
    • Kulessa H, Frampton J, Graf T. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes Dev 1995; 9: 1250-62.
    • (1995) Genes Dev , vol.9 , pp. 1250-1262
    • Kulessa, H.1    Frampton, J.2    Graf, T.3
  • 362
    • 0033485592 scopus 로고    scopus 로고
    • BSAP/Pax5A expression blocks survival and expansion of early myeloid cells implicating its involvement in maintaining commitment to the B-lymphocyte lineage
    • Chiang MY, Monroe JG. BSAP/Pax5A expression blocks survival and expansion of early myeloid cells implicating its involvement in maintaining commitment to the B-lymphocyte lineage. Blood 1999; 94: 3621-32.
    • (1999) Blood , vol.94 , pp. 3621-3632
    • Chiang, M.Y.1    Monroe, J.G.2
  • 363
    • 0036193609 scopus 로고    scopus 로고
    • Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage
    • Anderson MK, Weiss AH, Hernandez-Hoyos G, Dionne CJ, Rothenberg EV. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage. Immunity 2002; 16: 285-96.
    • (2002) Immunity , vol.16 , pp. 285-296
    • Anderson, M.K.1    Weiss, A.H.2    Hernandez-Hoyos, G.3    Dionne, C.J.4    Rothenberg, E.V.5
  • 364
    • 0141455931 scopus 로고    scopus 로고
    • GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages
    • Iwasaki H, Mizuno S, Wells RA, Cantor AB, Watanabe S, Akashi K. GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Immunity 2003; 19: 451-62.
    • (2003) Immunity , vol.19 , pp. 451-462
    • Iwasaki, H.1    Mizuno, S.2    Wells, R.A.3    Cantor, A.B.4    Watanabe, S.5    Akashi, K.6
  • 365
    • 31444431706 scopus 로고    scopus 로고
    • Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors
    • Hsu CL, King-Fleischman AG, Lai AY, Matsumoto Y, Weissman IL, Kondo M. Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Proc Natl Acad Sci U S A 2006; 103: 672-7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 672-677
    • Hsu, C.L.1    King-Fleischman, A.G.2    Lai, A.Y.3    Matsumoto, Y.4    Weissman, I.L.5    Kondo, M.6
  • 366
  • 367
    • 0030581149 scopus 로고    scopus 로고
    • Chromatin unfolds
    • Felsenfeld G. Chromatin unfolds. Cell 1996; 86: 13-19.
    • (1996) Cell , vol.86 , pp. 13-19
    • Felsenfeld, G.1
  • 368
    • 0021963738 scopus 로고
    • High-resolution mapping of S1-and DNase I-hypersensitive sites in chromatin
    • Weintraub H. High-resolution mapping of S1-and DNase I-hypersensitive sites in chromatin. Mol Cell Biol 1985; 5: 1538-9.
    • (1985) Mol Cell Biol , vol.5 , pp. 1538-1539
    • Weintraub, H.1
  • 369
    • 0030838280 scopus 로고    scopus 로고
    • The lineage commitment of haemopoietic progenitor cells
    • Cross MA, Enver T. The lineage commitment of haemopoietic progenitor cells. Curr Opin Genet Dev 1997; 7: 609-13.
    • (1997) Curr Opin Genet Dev , vol.7 , pp. 609-613
    • Cross, M.A.1    Enver, T.2
  • 370
    • 0034837064 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylase as new anticancer agents
    • Jung M. Inhibitors of histone deacetylase as new anticancer agents. Curr Med Chem 2001; 8: 1505-11.
    • (2001) Curr Med Chem , vol.8 , pp. 1505-1511
    • Jung, M.1
  • 371
    • 0037441885 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression
    • Skov S, Rieneck K, Bovin LF et al. Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression. Blood 2003; 101: 1430-8.
    • (2003) Blood , vol.101 , pp. 1430-1438
    • Skov, S.1    Rieneck, K.2    Bovin, L.F.3
  • 372
    • 34547635995 scopus 로고    scopus 로고
    • Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis
    • Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale ST, Weissman IL. Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci U S A 2007; 104: 12371-6.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12371-6
    • Attema, J.L.1    Papathanasiou, P.2    Forsberg, E.C.3    Xu, J.4    Smale, S.T.5    Weissman, I.L.6
  • 373
    • 34147171123 scopus 로고    scopus 로고
    • Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells
    • Dahl JA, Collas P. Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells. Stem Cells 2007; 25: 1037-46.
    • (2007) Stem Cells , vol.25 , pp. 1037-1046
    • Dahl, J.A.1    Collas, P.2
  • 374
    • 33745549658 scopus 로고    scopus 로고
    • Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations
    • O'Neill LP, VerMilyea MD, Turner BM. Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations. Nat Genet 2006; 38: 835-41.
    • (2006) Nat Genet , vol.38 , pp. 835-841
    • O'Neill, L.P.1    VerMilyea, M.D.2    Turner, B.M.3
  • 375
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006; 125: 315-26.
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 376
    • 0029551592 scopus 로고
    • Bone marrow transplantation from bench to bedside
    • Thomas ED. Bone marrow transplantation from bench to bedside. Ann N Y Acad Sci 1995; 770: 34-41.
    • (1995) Ann N Y Acad Sci , vol.770 , pp. 34-41
    • Thomas, E.D.1
  • 377
    • 0032898493 scopus 로고    scopus 로고
    • A history of haemopoietic cell transplantation
    • Thomas ED. A history of haemopoietic cell transplantation. Br J Haematol 1999; 105: 330-9.
    • (1999) Br J Haematol , vol.105 , pp. 330-339
    • Thomas, E.D.1
  • 378
    • 0032030933 scopus 로고    scopus 로고
    • High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts
    • Uchida N, Tsukamoto A, He D, Friera AM, Scollay R, Weissman IL. High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts. J Clin Invest 1998; 101: 961-6.
    • (1998) J Clin Invest , vol.101 , pp. 961-966
    • Uchida, N.1    Tsukamoto, A.2    He, D.3    Friera, A.M.4    Scollay, R.5    Weissman, I.L.6
  • 379
    • 0033643040 scopus 로고    scopus 로고
    • Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer
    • Negrin RS, Atkinson K, Leemhuis T et al. Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer. Biol Blood Marrow Transplant 2000; 6: 262-71.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 262-271
    • Negrin, R.S.1    Atkinson, K.2    Leemhuis, T.3
  • 380
    • 0035544032 scopus 로고    scopus 로고
    • Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with recurrent indolent non-Hodgkin's lymphoma
    • Vose JM, Bierman PJ, Lynch JC et al. Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with recurrent indolent non-Hodgkin's lymphoma. Biol Blood Marrow Transplant 2001; 7: 680-7.
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 680-687
    • Vose, J.M.1    Bierman, P.J.2    Lynch, J.C.3
  • 381
    • 0034643512 scopus 로고    scopus 로고
    • Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer. Philadelphia Bone Marrow Transplant Group
    • Stadtmauer EA, O'Neill A, Goldstein LJ et al. Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer. Philadelphia Bone Marrow Transplant Group. N Engl J Med 2000; 342: 1069-76.
    • (2000) N Engl J Med , vol.342 , pp. 1069-1076
    • Stadtmauer, E.A.1    O'Neill, A.2    Goldstein, L.J.3
  • 382
    • 0030065539 scopus 로고    scopus 로고
    • Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma after treatment with cyclophosphamide and granulocyte-macrophage colony-stimulating factor
    • Gazitt Y, Tian E, Barlogie B et al. Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma after treatment with cyclophosphamide and granulocyte-macrophage colony-stimulating factor. Blood 1996; 87: 805-11.
    • (1996) Blood , vol.87 , pp. 805-811
    • Gazitt, Y.1    Tian, E.2    Barlogie, B.3
  • 383
    • 0034125386 scopus 로고    scopus 로고
    • Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma: impact of HSC dose on engraftment, safety, and immune reconstitution
    • Michallet M, Philip T, Philip I et al. Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma: impact of HSC dose on engraftment, safety, and immune reconstitution. Exp Hematol 2000; 28: 858-70.
    • (2000) Exp Hematol , vol.28 , pp. 858-870
    • Michallet, M.1    Philip, T.2    Philip, I.3
  • 384
    • 0034691092 scopus 로고    scopus 로고
    • AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
    • Miyamoto T, Weissman IL, Akashi K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci U S A 2000; 97: 7521-6.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7521-7526
    • Miyamoto, T.1    Weissman, I.L.2    Akashi, K.3
  • 385
  • 386
    • 0030072986 scopus 로고    scopus 로고
    • Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment
    • Shizuru JA, Jerabek L, Edwards CT, Weissman IL. Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment. Biol Blood Marrow Transplant 1996; 2: 3-14.
    • (1996) Biol Blood Marrow Transplant , vol.2 , pp. 3-14
    • Shizuru, J.A.1    Jerabek, L.2    Edwards, C.T.3    Weissman, I.L.4
  • 387
    • 0033230515 scopus 로고    scopus 로고
    • CD8+TCR+ and CD8+TCR-cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers
    • Gandy KL, Domen J, Aguila H, Weissman IL. CD8+TCR+ and CD8+TCR-cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 1999; 11: 579-90.
    • (1999) Immunity , vol.11 , pp. 579-590
    • Gandy, K.L.1    Domen, J.2    Aguila, H.3    Weissman, I.L.4
  • 388
    • 0028006820 scopus 로고
    • Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells
    • Kaufman CL, Colson YL, Wren SM, Watkins S, Simmons RL, Ildstad ST. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 1994; 84: 2436-46.
    • (1994) Blood , vol.84 , pp. 2436-2446
    • Kaufman, C.L.1    Colson, Y.L.2    Wren, S.M.3    Watkins, S.4    Simmons, R.L.5    Ildstad, S.T.6
  • 389
    • 0027294049 scopus 로고
    • Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans
    • Martin PJ. Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans. J Exp Med 1993; 178: 703-12.
    • (1993) J Exp Med , vol.178 , pp. 703-712
    • Martin, P.J.1
  • 390
    • 0034662933 scopus 로고    scopus 로고
    • Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection
    • Shizuru JA, Weissman IL, Kernoff R, Masek M, Scheffold YC. Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection. Proc Natl Acad Sci U S A 2000; 97: 9555-60.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9555-9560
    • Shizuru, J.A.1    Weissman, I.L.2    Kernoff, R.3    Masek, M.4    Scheffold, Y.C.5
  • 391
    • 0025126814 scopus 로고
    • Induction of peripheral tolerance to class I major histocompatibility complex (MHC) alloantigens in adult mice: transfused class I MHC-incompatible splenocytes veto clonal responses of antigen-reactive Lyt-2+ T cells
    • Heeg K, Wagner H. Induction of peripheral tolerance to class I major histocompatibility complex (MHC) alloantigens in adult mice: transfused class I MHC-incompatible splenocytes veto clonal responses of antigen-reactive Lyt-2+ T cells. J Exp Med 1990; 172: 719-28.
    • (1990) J Exp Med , vol.172 , pp. 719-728
    • Heeg, K.1    Wagner, H.2
  • 393
    • 0037039379 scopus 로고    scopus 로고
    • Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance
    • Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A 2002; 99: 351-8.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 351-358
    • Steinman, R.M.1    Nussenzweig, M.C.2
  • 394
    • 0037093290 scopus 로고    scopus 로고
    • Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation
    • Millan MT, Shizuru JA, Hoffmann P et al. Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation. Transplantation 2002; 73: 1386-91.
    • (2002) Transplantation , vol.73 , pp. 1386-1391
    • Millan, M.T.1    Shizuru, J.A.2    Hoffmann, P.3
  • 395
    • 0037219227 scopus 로고    scopus 로고
    • Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice
    • Beilhack GF, Scheffold YC, Weissman IL et al. Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice. Diabetes 2003; 52: 59-68.
    • (2003) Diabetes , vol.52 , pp. 59-68
    • Beilhack, G.F.1    Scheffold, Y.C.2    Weissman, I.L.3
  • 396
    • 34548040947 scopus 로고    scopus 로고
    • Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells
    • Smith-Berdan S, Gille D, Weissman IL, Christensen JL. Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells. Blood 2007; 110: 1370-8.
    • (2007) Blood , vol.110 , pp. 1370-1378
    • Smith-Berdan, S.1    Gille, D.2    Weissman, I.L.3    Christensen, J.L.4
  • 397
    • 0037114640 scopus 로고    scopus 로고
    • Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation
    • BitMansour A, Burns SM, Traver D et al. Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation. Blood 2002; 100: 4660-7.
    • (2002) Blood , vol.100 , pp. 4660-4667
    • BitMansour, A.1    Burns, S.M.2    Traver, D.3
  • 398
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz OH, Valdez R, Theisen BK et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006; 441: 418-19.
    • (2006) Nature , vol.441 , pp. 418-419
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3
  • 399
    • 0037092955 scopus 로고    scopus 로고
    • In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
    • Wiemels JL, Xiao Z, Buffler PA et al. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 2002; 99: 3801-5.
    • (2002) Blood , vol.99 , pp. 3801-3805
    • Wiemels, J.L.1    Xiao, Z.2    Buffler, P.A.3
  • 400
    • 0031471132 scopus 로고    scopus 로고
    • Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots
    • Gale KB, Ford AM, Repp R et al. Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots. Proc Natl Acad Sci U S A 1997; 94: 13950-4.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 13950-4
    • Gale, K.B.1    Ford, A.M.2    Repp, R.3
  • 401
    • 18644369598 scopus 로고    scopus 로고
    • Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia
    • Hjalgrim LL, Madsen HO, Melbye M et al. Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia. Br J Cancer 2002; 87: 994-9.
    • (2002) Br J Cancer , vol.87 , pp. 994-999
    • Hjalgrim, L.L.1    Madsen, H.O.2    Melbye, M.3
  • 402
    • 0032572924 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. Euro pean Organization for Research and Treatment of Cancer -Childhood Leukemia Cooperative Group
    • Cave H, van der Werfften Bosch J, Suciu S et al. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. Euro pean Organization for Research and Treatment of Cancer -Childhood Leukemia Cooperative Group. N Engl J Med 1998; 339: 591-8.
    • (1998) N Engl J Med , vol.339 , pp. 591-598
    • Cave, H.1    van der Werfften Bosch, J.2    Suciu, S.3
  • 403
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 404
    • 0030988803 scopus 로고    scopus 로고
    • Lack of expression of Thy-a (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo
    • Blair A, Hogge De, Ailles LE, Lansdorp PM, Sutherland HJ. Lack of expression of Thy-a (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood 1997; 89: 3104-12.
    • (1997) Blood , vol.89 , pp. 3104-3112
    • Blair, A.1    Hogge De Ailles, L.E.2    Lansdorp, P.M.3    Sutherland, H.J.4
  • 405
    • 17944376561 scopus 로고    scopus 로고
    • AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
    • Yuan Y, Zhou L, Miyamoto T et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci U S A 2001; 98: 10398-403.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10398-403
    • Yuan, Y.1    Zhou, L.2    Miyamoto, T.3
  • 406
    • 0030615230 scopus 로고    scopus 로고
    • A PMLRARalpha transgene initiates murine acute promyelocytic leukemia
    • Brown D, Kogan S, Lagasse E et al. A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A 1997; 94: 2551-6.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2551-2556
    • Brown, D.1    Kogan, S.2    Lagasse, E.3
  • 407
    • 0035910748 scopus 로고    scopus 로고
    • BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia
    • Kogan SC, Brown DE, Shultz DB et al. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia. J Exp Med 2001; 193: 531-43.
    • (2001) J Exp Med , vol.193 , pp. 531-543
    • Kogan, S.C.1    Brown, D.E.2    Shultz, D.B.3
  • 408
    • 0032126364 scopus 로고    scopus 로고
    • Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
    • Traver D, Akashi K, Weissman IL, Lagasse E. Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity 1998; 9: 47-57.
    • (1998) Immunity , vol.9 , pp. 47-57
    • Traver, D.1    Akashi, K.2    Weissman, I.L.3    Lagasse, E.4
  • 409
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    • Passegue E, Jamieson CH, Ailles LE, Weissman IL. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci U S A 2003; 100(Suppl 1): 11842-9.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.SUPPL. 1 , pp. 11842-11849
    • Passegue, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 410
    • 0035846912 scopus 로고    scopus 로고
    • Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage
    • Passegue E, Jochum W, Schorpp-Kistner M, Mohle-Steinlein U, Wagner EF. Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell 2001; 104: 21-32.
    • (2001) Cell , vol.104 , pp. 21-32
    • Passegue, E.1    Jochum, W.2    Schorpp-Kistner, M.3    Mohle-Steinlein, U.4    Wagner, E.F.5
  • 411
    • 10944235028 scopus 로고    scopus 로고
    • Chronic versus acute myelogenous leukemia: a question of self-renewal
    • Jamieson CH, Weissman IL, Passegue E. Chronic versus acute myelogenous leukemia: a question of self-renewal. Cancer Cell 2004; 6: 531-3.
    • (2004) Cancer Cell , vol.6 , pp. 531-533
    • Jamieson, C.H.1    Weissman, I.L.2    Passegue, E.3
  • 412
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • Jamieson CH, Ailles LE, Dylla SJ et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004; 351: 657-67.
    • (2004) N Engl J Med , vol.351 , pp. 657-667
    • Jamieson, C.H.1    Ailles, L.E.2    Dylla, S.J.3
  • 413
    • 34547415968 scopus 로고    scopus 로고
    • CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia
    • Hosen N, Park CY, Tatsumi N et al. CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc Natl Acad Sci U S A 2007; 104: 11008-13.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 11008-11013
    • Hosen, N.1    Park, C.Y.2    Tatsumi, N.3
  • 414
    • 34547623918 scopus 로고    scopus 로고
    • Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function
    • Isken O, Maquat LE. Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes Dev 2007; 21: 1833-56.
    • (2007) Genes Dev , vol.21 , pp. 1833-1856
    • Isken, O.1    Maquat, L.E.2
  • 415
    • 38049123402 scopus 로고    scopus 로고
    • MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
    • Mi S, Lu J, Sun M et al. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci U S A 2007; 104: 19971-6.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19971-6
    • Mi, S.1    Lu, J.2    Sun, M.3
  • 416
  • 417
    • 37349032529 scopus 로고    scopus 로고
    • MiRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia
    • Zanette DL, Rivadavia F, Molfetta GA et al. miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Braz J Med Biol Res 2007; 40: 1435-40.
    • (2007) Braz J Med Biol Res , vol.40 , pp. 1435-1440
    • Zanette, D.L.1    Rivadavia, F.2    Molfetta, G.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.