High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts

Journal of Clinical Investigation

Volumn 101, Issue 5, 1998, Pages 961-966

  Uchida, Nobuko ^a   Tsukamoto, Ann ^a   He, Dongping ^a   Friera, Annabelle M ^a   Scollay, Roland ^a   Weissman, Irving L ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hematopoiesis; Hematopoietic stem cell transplantation; Mobilized peripheral blood

Indexed keywords

RHODAMINE 123; STEM CELL FACTOR; THY 1 ANTIGEN;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION PROTECTION;

EID: 0032030933     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1681     Document Type: Article

References (23)

1. Juttner, C., and L. To. 1994. Autologous peripheral blood stern cell transplantation: potential advantages, practical considerations, and initial clinical results. In Clinical Bone Marrow Transplantation: a Reference Text Book. K. Atkinson, editor. Cambridge University Press, New York. 142.
2. Spangrude, G.J., S. Heimfeld, and I.L. Weissman. 1988. Purification and characterization of mouse hematopoietic stem cells. Science. 241:58-62.
3. + cells are the only stem cells in C57B1/Ka-Thy-1.1 bone marrow. J. Exp. Med. 175:175-184.
4. Morrison, S.J., and I.L. Weissman. 1994. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity. 1:661-673.
5. + hematopoietic stem cells. Blood. 83:3758-3779.
6. Zimmerman, T.M., W.J. Lee, J.G. Bender, R. Mick, and S.F. Williams. 1995. Quantitative CD34 analysis may be used to guide peripheral blood stem cell harvests. Bone Marrow Transplant. 15:439-444.
7. Negrin, R.S., C.R. Kusnierz-Glaz, B.J. Still, J.R. Schriber, N.J. Chao, G.D. Long, C. Hoyle, W.W. Hu, S.J. Horning, B.W. Brown, et al. 1995. Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-Hodgkin's lymphoma. Blood. 85: 3334-3341.
8. Uchida, N., D. He, A. Friera, M. Reitsma, D. Sasaki, B. Chen, and A. Tsukamoto. 1997. The unexpected G0/G1 cell cycle status of mobilized hematopoietic stem cells from peripheral blood. Blood. 89:465-472.
9. Morrison, S.J., D.E. Wright, and I.L. Weissman. 1997. Cyclophosphamide/G-CSF induces hematopoietic stem cells to proliferate prior to mobilization. Proc. Natl. Acad. Sci. USA. 94:1908-1913.
10. Spangrude, G.J., D.M. Brooks, and D.B. Tumas. 1995. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. Blood. 85: 1006-1016.
11. Bertoncello, I., G.S. Hodgson, and T.R. Bradley. 1985. Multiparameter analysis of transplantable hemopoietic stem cells. I. The separation and enrichment of stem cells homing to marrow and spleen on the basis of rhodamine-123 fluorescence. Exp. Hematol. 13:999-1006.
12. Spangrude, G.J., and G.R. Johnson. 1990. Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc. Natl. Acad. Sci. USA. 87: 7433-7437.
13. Chaudhary, P.M., and I.G. Roninson. 1991. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell. 66:85-96.
14. Udomsakdi, C., C.J. Eaves. H.J. Sutherland, and P.M. Lansdorp. 1991. Separation of functionally distinct subpopulations of primitive human hematopoietic cells using rhodamine-123. Exp. Hematol. 19:338-342.
15. Zijlmans, J.M.. J.W. Visser, K. Kleiverda, P.M. Kluin, R. Willemze, and W.E. Fibbe. 1995. Modification of rhodamine staining allows identification of hematopoietic stem cells with preferential short-term or long-term bone marrow-repopulating ability. Proc. Natl. Acad. Sci. USA. 92:8901-8905.
16. Uchida, N., J. Combs, S. Chen, E. Zanjani, R. Hoffman, and A. Tsukamoto. 1996. Primitive human hematopoietic cells displaying differential efflux of the rhodamine 123 dye have distinct biological activities. Blood. 88:1297-1305.
17. Shizuru, J.A., L. Jerabek, C.T. Edwards, and I.L. Weissman. 1996. Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment. Biol. Blood Marrow Transplant. 2:3-14.
18. Heimfeld, S., S. Hudak, I. Weissman, and D. Rennick. 1991. The in vitro response of phenotypically defined mouse stem cells and myeloerythroid progenitors to single or multiple growth factors. Proc. Natl. Acad. Sci. USA. 88: 9902-9906.
19. Nibley, W., and G. Spangrude. 1996. Patterns of myleoid engraftment by progenitor cell subsets in mouse spleen, bone marrow, and blood. Blood. 88: 456a. (Abstr.)
20. Mavroudis, D., E. Read, M. Cottler-Fox, D. Couriel, J. Molldrem, C. Carter, M. Yu, C. Dunbar, and J. Barreit. 1996. CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies. Blood. 88:3223-3229.
21. - peripheral blood stem cells (PBSC) transplantation after high dose therapy for patients with multiple myeloma. Blood. 88:595a. (Abstr.)
22. Szilvassy, S., K. Weller, B. Chen, C. Juttner, A. Tsukamoto, and R. Hoffman. 1996. Partially differentiated ex vivo expanded cells accelerate hematologic recovery in myeloablated mice transplanted with highly enriched long-term repopulating stem cells. Blood. 88:3642-3653.
23. Yu, Y.Y., V. Kumar, and M. Bennett. 1992. Murine natural killer cells and marrow graft rejection. Annu. Rev. Immunol. 10:189-213.