Fates human B-cell precursors

Blood

Volumn 96, Issue 1, 2000, Pages 9-23

  LeBien, Tucker W ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; AGAMMAGLOBULINEMIA; APOPTOSIS; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW CELL; HUMAN; HUMAN CELL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; X LINKED AGAMMAGLOBULINEMIA;

EID: 0034234756     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.1.9     Document Type: Article

References (220)

1. Gathings WE, Lawlon AR, Cooper MD. Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans. Eur J Immunol. 1977:7:804-810.
2. Solvason N, Kearney JF. The human fetal omentum: a site of B cell generation. J Exp Med. 1992; 175:397-404.
3. Nuñez C. Nishimoto N, Gartland GL, et al. B cells are generated throughout life in humans. J Immunol. 1996;156:866-872.
4. Brashem CJ, Kersey JH, Bollum FJ, LeBien TW. Ontogenic studies of lymphoid progenitor cells in human bone marrow. Exp Hematol. 1982;10:886-892.
5. Jamieson BD, Douek DC, Killian S, et al. Generation of functional thymocytes in the human adult. Immunity. 1999;10:569-575.
6. Jennings CD, Foon KA. Recent advances in flow cytometry: application to the diagnosis of hematologic malignancy. Blood. 1997;90:2863-2892.
7. Galy A, Travis M, Cen D, Chen B. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity. 1995;3:459-473.
8. Ryan DH, Nuccie BL, Ritterman I, Liesveld JL, Abboud CN, Insel RA. Expression of interleukin-7 receptor by lineage-negative human bone marrow progenitors with enhanced lymphoid proliferative potential and B-lineage differentiation capacity. Blood. 1997;89:929-940.
9. + human bone marrow cells is a phenotypic alteration for committed lymphoid progenitors. J Immunol. 1999;163:3612-3620.
10. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91:661-672.
11. H gene segment transcription and rearrangement before surface expression of the pan-B-cell marker CD19 in normal human bone marrow. Blood. 1997;90:736-744.
12. + cells. Blood. 1997;90:4014-4021.
13. Dworzak MN, Fritsch G, Fröschl G, Printz D, Gadner H: Four-color flow cytometric investigation of terminal deoxynucleotidyl transferase-positive lymphoid precursors in pediatric bone marrow: CD79a expression precedes CD19 in early B-cell ontogeny. Blood. 1998;92:3203-3209.
14. Wang Y-H, Nomura J, Faye-Petersen OM, Cooper MD. Surrogate light chain production during B cell differentiation: differential intracellular versus cell surface expression. J Immunol. 1998;161: 1132-1139.
15. Spits H, Blom B, Jaleco AC, et al. Early stages in the development of human T, natural killer and thymic dendritic cells, Immunol Rev. 1998;165: 75-86.
16. Akashi K, Traver D, Kondo M, Weissman IL. Lymphoid development from hematopoietic stem cells. Int J Hematol. 1999;69:217-226.
17. Pallard C, Stegmann APA, van Kleffens T, Smart F. Venkitaraman A, Spits H. Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity. 1999;10:525-535.
18. Osmond DG, Rolink A, Melchers F. Murine B lymphopoiesis: towards a unified model, Immunol Today. 1998;19:65-80.
19. Hardy RR. Carmack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med. 1991;173:1213-1225.
20. Li YS, Wasserman R, Hayakawa K, Hardy RR. Identification of the earliest B-lineage stage in mouse bone marrow. Immunity. 1996;5:527-535.
21. Payne KJ, Medina KL, Kincade PW. Loss of c-kit accompanies B-lineage commitment and acquisition of CD45R by most murine B-lymphocyte precursors. Blood. 1999;94:713-725.
22. Loken MR, Shah VO, Dattilio KL, Civin CI. Flow cytometric analysis of human bone marrow, II: normal B lymphocyte development. Blood. 1987; 70:1316-1324.
23. LeBien TW, Wormann B. Villablanca JG, et al. Multiparameter flow cytometric analysis of human fetal bone marrow B cells. Leukemia. 1990;4:354-358.
24. Ghia P, ten Boekel E, Sanz E, de la Hera A, Rolink A, Melchers F. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci. J Exp Med. 1997;184:2217-2229.
25. -) proB complex: cell surface expression and biochemical structure of a putative transducing receptor. Blood. 1999;93:4336-4346.
26. Dittel BN, LeBien TW. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34. J Immunol. 1995;154:58-67.
27. Li YS, Hayakawa K, Hardy RR. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med. 1993;178:951-960
28. Pauza ME, Rehmann JA, LeBien TW. Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: human B cells can simultaneously express cell surface kappa and lambda light chains. J Exp Med. 1993;178:139-149.
29. Ghia P, Gratwohl A, Signer E, Winkler TH, Melchers F, Rolink AG. Immature B cells from human and mouse bone marrow can change their surface light chain expression. Eur J Immunol 1995;25:3108-3114.
30. Giachino C, Padovan E, Lanzavecchia A. Kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire. J Exp Med. 1995;181:1245-1250.
31. Benschop RJ. Cambier JC. B cell development: signal transduction by antigen receptors and their surrogates. Curr Opin Immunol. 1999;11:143-151.
32. Melchers F, Karasuyama H, Haasner D, et al. The surrogate light chain in B-cell development, Immunol Today. 1993;14:60-68.
33. Minegishi Y, Coustan-Smith E, Wang Y-H, Cooper MD, Campana D, Conley ME. Mutations in the human λ5/14.1 gene result in B cell deficiency and agammaglobulinemia. J Exp Med. 1998;187: 71-77.
34. Lassoued K, Nunez CA, Billips L, et al. Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell. 1993;73:73-86.
35. Sanz E, de la Hera A. A novel anti-Vpre-B antibody identifies immunoglobulin-surrogate receptors on the surface of human pro-B cells. J Exp Med. 1996;183:2693-2698.
36. Meffre E, Fougereau M, Argenson JN, Aubaniac JM, Schiff C. Cell surface expression of surrogate light chain (ψLC) in the absence of μ on human pro-B cell lines and normal pro-B cells. Eur J Immunol. 1996;26:2172-2180.
37. Wang Y-H, Nomura J, Faye-Petersen OM, Cooper MD. Surrogate light chain production during B cell differentiation: differential intracellular versus cell surface expression. J Immunol. 1998;161: 1132-1139.
38. Tsuganezawa K, Kiyokawa N, Matsuo Y, et al. Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B cell receptor. Blood. 1998;92:4317-4324.
39. H repertoire selection and cell signaling at the preB cell stage. J Immunol. 1999;162:41-50.
40. Lassoued K, Illges H, Benlagha K, Cooper MD. Fate of surrogate light chains in B lineage cells. J Exp Med. 1996;183:421-429.
41. Kitamura D, Kudo A, Schaal S, Müller W, Melchers F, Rajewsky K. A critical role of lambda 5 protein in B cell development. Cell. 1992;69: 823-831.
42. Kubagawa H, Cooper MD, Carroll AJ, Burrows PD. Light-chain gene expression before heavy-chain rearrangement in pre-B cells transformed by Epstein-Barr virus. Proc Natl Acad Sci USA. 1989;86:2356-2360.
43. Novobrantseva TI, Martin VM, Pelanda R, Müller W, Rajewsky K, Ehlich A. Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice. J Exp Med. 1999;189:75-88.
44. H gene reperloire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity. 1997;7:357-368.
45. Kline GH, Hartwell L, Beck-Engeser GB, et al. Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional μ heavy chains. J Immunol. 1998;161:1608-1618.
46. Wasserman R, Li YS, Shinton SA, et al. A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly. J Exp Med. 1998;187:259-264.
47. Shiokawa S, Mortari F, Lima JO, et al. IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth. J Immunol. 1999;162:6060-6070.
48. Rao SP, Riggs JM, Friedman DF, Scully MS, Le-Bien TW, Silberstein LE. Biased VH gene USAge in early lineage human B cells: evidence for preferential Ig gene rearrangement in the absence of selection. J Immunol. 1999;163:2732-2740.
49. Shatter AL, Schlissel MS. A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development. J Immunol. 1997;159:1265-1275.
50. Pillai S. The chosen few? Positive selection and the generation of naive B lymphocytes. Immunity. 1999;10:493-502.
51. Bossy D, Salamero J, Olive D, Fougereau M, Schiff C. Structure, biosynthesis, and transduction properties of the human μ-ψ L complex: similar behavior of preB and intermediate preB-B cells in transducing ability, Int Immunol. 1993;5: 467-478.
52. Kuwahara K, Kawai T, Mitsuyoshi S, etal. Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphalidylinositol 3-kinase. Int Immunol. 1996; 8:1273-1285.
53. Minegishi Y, Hendershot LM, Conley ME. Novel mechanisms control the folding and assembly of λ5/14.1 and VpreB to produce an intact surrogate light chain. Proc Natl Acad Sci U S A. 1999;96: 3041-3046.
54. Melchers F. Fit for life in the immune system? Surrogate L chain tests H chains that test L chains. Proc Natl Acad Sci U S A. 1999;96:2571-2573.
55. Karasuyama H, Rolink A, Melchers F. A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines. J Exp Med. 1993;178:469-478.
56. LeBien TW. B-cell lymphopoiesis in mouse and man. Curr Opin Immunol. 1998;10:188-195.
57. Nagata K, Nakamura T, Kitamura F, et al. The Igα/Igβ heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity. 1997;7:559-570.
58. Gong S, Nussenzweig MC. Regulation of an early developmental checkpoint in the B cell pathway by Igβ. Science. 1996;272:411-414.
59. Namen AE, Lupton S, Hjerrild K, et al. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature. 1988;333:571-573.
60. Candéias S, Muegge K, Durum SK. IL-7 receptor and VDJ recombination: trophic versus mechanistic actions. Immunity. 1997;5:501-508.
61. Kincade PW, Medina K, Smithson G, et al. Life/death decisions in B lymphocyte precursors. In: Monroe JG, Rothenberg EV, eds. Molecular Biology of B-Cell and T-Cell Development. Totowa, NJ: Humana Press; 1998:177-196.
62. Corcoran AE, Smart FM, Cowling HJ, Crompton T, Owen MJ, Venkitaraman AR. The interleukin-7 receptor α chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J. 1996;15:1924-1932.
63. Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 1998;391:904-907.
64. von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, Murray R. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med. 1995;181: 1519-1526.
65. Peschon JJ, Morrissey PJ, Grabstein KH, et al. Early lymphocyte expansion is severely impaired in interleukin-7 receptor-deficient mice. J Exp Med. 1994;180:1955-1960.
66. Cao X, Shores EW, Hu-Li J, et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity. 1995;2:223-238.
67. DiSanto JP, Muller W, Guy-Grand D. Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin-2 receptor γ chain. Proc Natl Acad Sci U S A. 1995;92:377-381.
68. Nosaka T, van Deursen JMA, Tripp RA, et al. Defective lymphoid development in mice lacking Jak3. Science. 1995;270:800-802.
69. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3, Science. 1995;270:794-797.
70. Friend SL, Hosier S, Nelson A, Foxworthe D, Williams DE, Farr A. A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells. Exp Hematol. 1994; 22:321-328.
71. Ray RJ, Furlonger C, Williams DE, Paige CJ. Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur J Immunol. 1996;26:10-16.
72. Levin SD, Koelling RM, Friend SL, et al. Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. J Immunol. 1999; 162:677-683.
73. Wolf ML, Buckley JA, Goldfarb A1 Law C-L, Le-Bien TW. Development of a bone marrow culture for maintenance and growth of normal human B cell precursors. J Immunol. 1991;147:3324-3330.
74. Saeland S, Duvert V, Pandrau D, et al. Interleukin-7 induces the proliferation of normal human B-cell precursors. Blood. 1991;78:2229-2238.
75. Moreau I, Duvert V, Banchereau J, Saeland S. Culture of human fetal B-cell precursors on bone marrow stroma maintains highly proliferate CD20dim cells. Blood. 1993;81:1170-1178.
76. Moreau I, Duvert V, Caux C, et al. Myofibroblastic stromal cells isolated from human bone marrow induce the proliferation of both early myeloid and B-lymphoid cells. Blood. 1993;82:2396-2405.
77. Noguchi M, Yi H, Rosenblatt HM, et al. Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans. Cell. 1993;73:147-157.
78. Maachi P, Villa A, Giliani S, et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature. 1995;377:65-68.
79. Russell SM, Tayebi N, Nakajima H. et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science. 1995; 270:797-800.
80. Puel A, Ziegler SF, Buckley RH, Leonard WJ. Defective IL7R expression inT(-)B(+)NK(+) severe combined immunodeficiency. Nature Genet. 1998;20:394-397.
81. Pribyl JAR, LeBien TW. Interteukin 7 independent development of human B cells. Proc Natl Acad Sci U S A. 1996;93:10348-10353.
82. Wolf ML, Weng W-K, Stieglbauer K. Shah N, LeBien TW. Functional effect of IL-7-enhanced CD19 expression on human B-cell precursors. J Immunol. 1993;151:138-148.
83. Billips LG, Nunez CA, Bertrand FE III, et al. Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors. J Exp Med. 1995;182:973-982.
84. Cluitmans FHM, Esendam BHJ, Landegent JE, Willemze R, Falkenburg JH. Constitutive in vivo cytokine and hematopoietic growth factor gene expression in the bone marrow and peripheral blood of healthy individuals. Blood. 1995;85: 2038-2044.
85. Ryan DH, Nuccie BL, Ritterman I, Liesveld JL, Abboud CN. Cytokine regulation of early human lymphopoiesis. J Immunol. 1994;152:5250-5258.
86. Funk PE, Stephan RP, Witte PL. Vascular cell adhesion molecule 1-positive reticular cells express interleukin-7 and stem cell factor in the bone marrow. Blood. 1995;86:2661-2671.
87. Namikawa R, Muench MO, De Vries JE, Roncarolo MG. The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in vitro. Blood. 1996;87:1881-1890.
88. McClanahan T, Culpepper J, Campbell D, et al. Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand. Blood. 1996;88:3371-3382.
89. Lisovsky M, Braun SE, Ge Y, et al. Flt3-ligand production by human bone marrow stromal cells. Leukemia. 1996;10:1012-1018.
90. Oritani K, Kincade PW. Identification of stromal cell products that interact with pre-B cells. J Cell Biol. 1996;134:771-782.
91. Oritani K, Kanakura Y, Aoyama K, et al. Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. Blood, 1997;90:3404-3413.
92. Sage H, Vernon RB, Funk SE, Everitt EA, Angello J: SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca2 + -dependent binding in the extracellular matrix. J Cell Biol. 1989;109:341-356.
93. Raines EW, Lane TF, Iluera-Arispe ML, Ross R, Sage EH. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits binding of PDGF to its receptors. Proc Natl Acad Sci U S A. 1992; 89:1281-1285.
94. Girard J-P. Springer TA, Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC. Immunity. 1995;2:113-123.
95. Borghesi LA, Yamashita Y, Kincade PW. Heparan sulfate proteoglycans mediate interleukin-7-dependent B lymphopoiesis. Blood. 1999;93:140-148.
96. Gupta P. McCarthy JB, Verfaillie CM. Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells. Blood. 1996;87:3229-3236.
97. Nagasawa T, Hirota S, Tachibana K, et al Defects in B-cell lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996;383:635-638
98. Tachibana K, Hirota S, Lizasa H, et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 1998; 393:591-594.
99. Ma Q, Jones D, Borghesan PR, et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A. 1998; 95:9448-9453.
100. Ma Q, Jones D, Springer TA. The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity. 1999; 10:463-471.
101. Aiuti A, Tavian M, Cipponi A, et al. Expression of CXCR4, the receptor tor stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors. Eur J Immunol. 1999;29: 1823-1831.
102. Fedyk ER, Ryan DH, Ritterman I, Springer TA. Maturation decreases responsiveness of human bone marrow B lineage cells to stromal-derived factor 1 (SDF-1). J Leukoc Biol. 1999;66:667-673.
103. Honczarenko M, Douglas RS, Mathias C, Lee B, Ratajczak MZ, Silberstein LE. SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells. Blood. 1999;94:2990-2998.
104. Coulomb-L'Hermin A. Amara A, Schiff C, et al. Stromal cell-derived factor 1 (SDF-1) and antenatal human B cell lymphopoiesis: expression of SDF-1 by mesothelial cells and biliary ductal plate epithelial cells. Proc Natl Acad Sci U S A. 1999; 96:8585-8590.
105. Jarvis LJ, LeBien TW. Cytokine and stromal influences on early B-cell development. In: Monroe JG, Rothenberg EV, eds. Molecular Biology of B-Cell and T-Cell Development. Totowa, NJ: Humana Press; 1998:231-251.
106. Ryan DH, Tang J. Regulation of human B cell lymphopoiesis by adhesion molecules and cytokines. Leuk Lymphoma 1995;17:375-389.
107. Ryan DH, Nuccie BL, Abboud CN, Winslow JM. Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B-cell precursors to cultured bone marrow adherent cells. J Clin Invest. 1991;88:995-1004.
108. Dittel BN, McCarthy JB, Wayner EA, LeBien TW. Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1). Blood. 1993; 81:2272-2282.
109. Murti KG, Brown PS, Kumagai MA, Campana D. Molecular interactions between human B-cell progenitors and the bone marrow microenvironment. Exp Cell Res. 1996;10:47-58.
110. Jarvis LJ, LeBien TW. Stimulation of human bone marrow stromal cell tyrosine kinases and IL-6 production by contact with B lymphocytes. J Immunol. 1995;155:2359-2368.
111. Jarvis LJ, Maguire JE, LeBien TW. Contact between human bone marrow stromal cells and B lymphocytes enhances very late antigen-4/vascular cell adhesion molecule-1 -independent tyrosine phosphorylation of focal adhesion kinase, paxillin, and ERK2 in stromal cells. Blood. 1997; 90:1626-1636.
112. Rawlings DJ, Quan SG, Kato RM, Witte ON. Long-term culture system for selective growth of human B cell progenitors. Proc Natl Acad Sci U S A. 1995;92:1570-1574.
113. +/CD38 cord blood stem cells into B cell progenitors in vitro. Exp Hematol. 1997;25:66-72.
114. Kurosaka D, LeBien TW, Pribyl JAR. Comparative studies of different stromal cell microenvironments in support of human B cell development. Exp Hematol. 1999;27:1271-1281.
115. + multipotent progenitors to Ig-secreting cells. Blood. 1998;92:4509-4520.
116. + progenitor cells from human cord blood generate B lymphocytes and granulocytes. Blood. 1997;89:3554-3564.
117. Nishihara M, Wada Y, Ogami K, et al. A combination of stem cell factor and granulocyte colony-stimulating factor enhances the growth of human progenitor B cells supported by murine stromal cell line MS-5. Eur J Immunol. 1998;28:855-864.
118. + progenitors. Leukemia. 1998;12:764-771.
119. Miller JS, McCullar V, Punzel M, Lemischka IR, Moore KA. Single adult human CD34(+)/Lin-/CD38(-) progenitors give rise to natural killer cells, B-lineage cells, dendritic cells, and myeloid cells. Blood. 1999;93:96-106.
120. Shultz LD, Schweitzer PA, Christianson SW, et al. Multiple defects in innate and adaptive immunologic function in NOD/LISz-scid mice. J Immunol. 1995;154:180-191.
121. Greiner DL, Hesselton RA, Shultz LD. SCID mouse models of human stem cell engraftment. Stem Cells. 1998;16:166-177.
122. Bhatia M, Wang JCY, Kapp U, Bonnet D, Dick JE. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A. 1997;94:5320-5325.
123. Conneally E, Cashman J, Petzer A, Eaves C. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci U S A. 1997;94:9836-9841.
124. Hogan CJ, Shpall EJ, McNulty O, et al. Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. Blood. 1997;90:85-96.
125. van der Loo JC, Hannenberg H, Cooper RJ, Luo FY, Lazaridis EN, Williams DA. Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells. Blood. 1998;92:2556-2570.
126. Robin C, Pflumio F, Vainchenker W, Coulombel L. Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells. J Exp Med. 1999;189:1601-1610.
127. Harigaya K, Handa H. Generation of functional clonal cell lines from human bone marrow stroma. Proc Natl Acad Sci U S A, 1985;82:3477-3480.
128. Roecklein BA, Torok-Storb B. Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes. Blood. 1995;85:997-1005.
129. Li L, Milner LA, Deng Y, et al. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation ot 32D cells through interaction with Notch1. Immunity. 1998;8:43-55.
130. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal cells. Science. 1998;279:349-352.
131. Fischer A, Malissen B. Natural and engineered disorders of lymphocyte development. Science. 1998;280:237-243.
132. Rosen FS, Wedgwood RJ, Eibl MM, et al. Primary immunodeficiency diseases: report of a WHO scientific group. Clin Exp Immunol. 1997; 109(suppl):S1.
133. Conley ME, Cooper MD. Genetic basis of abnormal B cell development. Curr Opin Immunol. 1998;10:399-406.
134. Tsukada S, Saffran DC, Rawlings DJ, et al. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell. 1993;72:279-290.
135. Vetrie D, Vorechovsky I, Sideras P, et al. The gene involved in X-linked agammaglobulinemia is a member of the src family of protein-tryosine kinases. Nature. 1993;361:226-233.
136. Conley ME, Mathias D, Treadaway J, Minegishi Y, Rohrer J. Mutations in btk in patients with presumed X-linked agammaglobulinemia. Am J Hum Genet. 1998;62:1034-1043.
137. Vihinen M, Brandau O, Branden LJ, et al. BTK-base, mutation database for X-linked agamma-globulinemia (XLA). Nucleic Acids Res. 1998;26: 242-247.
138. Rawlings DJ. Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function. Clin Immunol. 1999; 91:243-253.
139. Campana D, Farrant J, Inamdar N, Webster AD, Janossy G. Phenotypic features and proliferative activity of B cell progenitors in X-linked agamma-globulinemia. J Immunol. 1990;145:1675-1680.
140. Thomas JD, Sideras P, Smith CIE, Vorechovsky I, Chapman V, Paul WE. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science. 1993;261:355-358.
141. Khan WN, Alt FW, Gerstein RM, et al. Defective B cell development and function in BTK-deficient mice. Immunity. 1995;3:283-299.
142. Kerner JD, Appleby MVM, Mohr RN, et al. Impaired expansion of mouse B cell progenitors lacking BTK. Immunity. 1995;3:301-312.
143. Hendriks RW, de Bruijn MFTR, Maas A, Dingjan GM, Karis A, Grosveld F. Inactivation of BTK by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO J. 1996;15:4862-4872.
144. de Weers M, Verschuren MCM, Kraakman MEM, et al. The Bruton's tryosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages. Eur J Immunol. 1993;23:3109-3114.
145. Smith CIE, Baskin B, Humire-Greiff P, et al. Expression of Bruton's agammaglobulinemia tryosine kinase gene, BTK, is selectively downregulated in T lymphocytes and plasma cells. J Immunol. 1994;152:557-565.
146. Scharenberg AM, El-Hillal O, Fruman DA, et al. Phosphatidylinositol-3,4,5-trisphosphate(Ptdlns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J. 1998;17:1961-1972.
147. Rawlings DJ, Scharenberg AM, Park H, et al. Activation of BTK by a phosphorylation mechanism initiated by Src family kinases. Science. 1996; 271:822-825.
148. Fluckiger AC, Li Z, Kato RM, et al. BTK/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. EMBO J. 1998;17:1973-1985.
149. Hashimoto S, Iwamatsu A, Ishiai M, et al. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK: functional significance of BTK-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood. 1999; 94:2357-2364.
150. Yel L, Minegishi Y, Coustan-Smith E, et al. Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. N Engl J Med. 1996;335: 1486-1493.
151. Minegishi Y, Coustan-Smith E, Rapalus L, Ersoy F, Campana D, Conley ME. Mutations in Igα (CD79a) result in a complete block in B-cell development. J Clin Invest. 1999;104:1115-1121.
152. Meffre E, LeDeist F, de Saint-Basile G, et al. A human non-XLA immunodeficiency disease characterized by blockage of B cell development at an early proB cell stage. J Clin Invest. 1996;98: 1519-1526.
153. Look AT. Oncogenic transcription factors in the human acute leukemias. Science. 1997;278: 1059-1064.
154. Pui CH. Recent advances in the biology and treatment of childhood acute lymphoblastic leukemia. Curr Opin Hematol. 1998;5:292-301.
155. Kersey JH. Fifty years of studies of the biology and therapy of childhood leukemia. Blood. 1997; 90:4243-4251.
156. Greaves M. Molecular genetics, natural history and the demise of childhood leukaemia. Eur J Cancer. 1999;35:173-185.
157. Raff MC. Social controls on cell survival and cell death. Nature. 1992;356:397-400.
158. Campana D, Coustan-Smith E, Manabe A, et al. Prolonged survival of B-lineage acute lymphoblastic leukemia cells is accompanied by overexpression of bcl-2 protein. Blood. 1993;81:1025-1031.
159. Griffiths SD, Goodhead DT, Marsden SJ, et al. Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis. J Exp Med. 1994;179:1789-1797.
160. Fang W, Mueller DL, Pennell CA, et al. Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene. Immunity. 1996;4:291-299.
161. Coustan-Smith E, Kitanaka A, Pui CH, et al. Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia. Blood. 1996; 87:1140-1146.
162. Salomons GS, Brady HJ, Verwijs-Janssen M, et al. The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia. Int J Cancer. 1997;71:959-965.
163. Uckun FM, Yang Z, Sather H, et al. Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: a Children's Cancer Group Study. Blood. 1997;89:3769-3777.
164. Jia L, Macey MG, Yin Y, Newland AC, Kelsey SM. Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis. Blood. 1999;93:2353-2359.
165. Campos L, Sabido O, Viallet A, Vasselon C, Guyotat D. Expression of apoptosis-controlling proteins in acute leukemia cells. Leuk Lymphoma. 1999;33:499-509.
166. Hogarth LA, Hall AG. Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. Blood. 1999;93:2671-2678.
167. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-1312.
168. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science. 1998;281:1322-1326.
169. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 1999;13:1899-1911.
170. Inaba T, Roberts WM, Shapiro LH, et al. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science. 1992; 257:531-534.
171. Hunger SP, Ohyashiki K, Toyama K, Cleary ML. Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17:19) acute lymphoblastic leukemia. Genes Dev. 1992;6:1608-1620.
172. Inaba T, Inukai T, Yoshihara T, et al. Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature. 1996;382: 541-544.
173. Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT. Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Proc Natl Acad Sci U S A. 1997;94:2609-2614.
174. Kurosawa H, Goi K, Inukai T, et al. Two candidate downstream target genes for E2A-HLF. Blood. 1999;93:321-332.
175. Inukai T, Inoue A, Kurosawa H, et al. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell. 1999;4: 343-352.
176. Honda H, Inaba T, Suzuki T, et al. Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia. Blood. 1999;93: 2780-2790.
177. Smith KS, Whan Rhee J, Naumovski L, Cleary ML. Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice. Mol Cell Biol. 1999;19: 4443-4451.
178. Nourse J, Mellentin JD, Galili N, et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell. 1990;60: 535-545.
179. Kamps MP, Murre C, Sun XH, Baltimore D. A new homeobox gene contributes the DNA binding domain of the t(1:19) translocation protein in pre-B ALL. Cell. 1990;60:547-555.
180. Hunger SP. Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. Blood. 1996;87:1211-1224.
181. Dedera DA, Waller EK, LeBrun DP, et al. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell. 1993;74:833-843.
182. Kamps MP, Baltimore D. E2A-Pbx1, the t(1;19) translocation protein of human pre-B cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice. Mol Cell Biol. 1993;13:351-357.
183. Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev. 1997; 11:3286-3305.
184. McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1999;96:11464-11469.
185. Dilly SA, Jagger CJ. Bone marrow stromal cell changes in hematological malignancies. J Clin Pathol. 1990;43:942-946.
186. Wormann B, Gesner TG, Mufson RA, LeBien TW. Proliferative effect of interleukin-3 on normal and leukemic human B cell precursors. Leukemia. 1989;3:399-404.
187. Uckun FM, Gesner TG, Song CW, Myers DE, Mulson A. Leukemic B-cell precursors express functional receptors for human interleukin-3. Blood. 1989;73:533-542.
188. Touw I, Groot-Loonen J, Broeders L, et al. Recombinant hematopoietic growth factors fail to induce a proliferative response in precursor B acute lymphoblastic leukemia. Leukemia. 1989;3: 356-362.
189. Touw I, Pouwels K, van Agthoven T, et al. Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia. Blood. 1990;75: 2097-2101.
190. Eder M, Ottmann OG, Hansen-Hagge TE, et al. Effects of recombinant human IL-7 on blast cell proliferation in acute lymphoblastic leukemia. Leukemia. 1990;4:533-540.
191. Skjonsberg C, Erikstein BK, Smeland EB, et al. Interleukin-7 differentiates a subgroup of acute lymphoblastic leukemias. Blood. 1991;77:2445-2450.
192. Makrynikola V, Kabral A, Bradstock KF. Effects of recombinant human cytokines on precursor-B acute lymphoblastic leukemia cells. Exp Hematol. 1991;19:674-679.
193. Mirro Jr J, Hurwitz CA, Behm FG, et al. Effects of recombinant human hematopoietic growth factors on leukemic blasts from children with acute myeloblastic or lymphoblastic leukemia. Leukemia. 1993;7:1026-1033.
194. Eder M, Hemmati P, Kalina U, et al. Effects of Flt3 ligand and interleukin-7 on in vitro growth of acute lymphoblastic leukemia cells. Exp Hematol. 1996; 24:371-377.
195. Pontvert-Delucq S, Hibner U, Vilmer E, et al. Heterogeneity of B lineage acute lymphoblastic leukemias (B-ALL) with regard to their in vitro spontaneous proliferation, growth factor response and BCL-2 expression. Leuk Lymphoma. 1996;21: 267-280.
196. Tang J, Scott G, Ryan DH. Subpopulations of bone marrow fibroblasts support VLA-4-mediated migration of B-cell precursors. Blood. 1993;82: 3415-3423.
197. Bradstock K, Makrynikola V, Bianchi A, Byth K. Analysis of the mechanism of adhesion of precursor-B acute lymphoblastic leukemia cells to bone marrow fibroblasts. Blood. 1993;82:3437-3444.
198. Makrynikola V, Bianchi A, Bradstock K, Gottlieb D, Hewson J. Migration of acute lymphoblastic leukemia cells into human bone marrow stroma. Leukemia. 1994;8:1734-1743.
199. Geijtenbeek TB, van Kooyk Y, van Vliet SJ, Renes MH, Raymakers RA, Figdor CG. High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. Blood. 1999;94:754-764.
200. Nishii K, Katayama N, Miwa H, et al. Survival of human B-cell precursors is supported by stromal cells and cytokines: association with the expression of bcl-2 protein. Br J Haematol. 1999;105:701-710.
201. Manabe A, Coustan-Smith E, Behm FG, Raimondi SC, Campana D. Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia. Blood. 1992;79:2370-2377.
202. Manabe A, Murti KG, Coustan-Smith E, et al. Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. Blood. 1994;83:758-766.
203. Ashley DM, Bol SJ, Kannourakis G. Human bone marrow stromal cell contact and soluble factors have different effects on the survival and proliferation of paediatric B-lineage acute lymphoblastic leukaemic blasts. Leuk Res. 1994;18:337-346.
204. Bradstock K, Blanchi A, Makrynikola V, Filshie R, Gottlieb D. Long-term survival and proliferation of precursor-B acute lymphoblastic leukemia cells on human bone marrow stroma. Leukemia. 1996;10:813-820.
205. Kumagai M, Manabe A, Pui C-H, et al. Stroma-supported culture of childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome. J Clin Invest. 1996;97:755-760.
206. Ito C, Kumagai M, Manabe A, et al. Hyperdiploid acute lymphoblastic leukemia with 51-65 chromosomes: a distinct biological entity with a marked propensity to undergo apoptosis. Blood. 1999;93: 315-320.
207. Matsuo Y, Drexler HG. Establishment and characterization of human B cell precursor-leukemia cell lines. Leuk Res. 1998;22:567-579.
208. Shah N, Oseth LL, LeBien TW. Development of a model for evaluating the interaction between human pre-B acute lymphoblastic leukemic cells and the bone marrow stromal cell microenvironment. Blood, 1998;92:3817-3828.
209. Lysholm AS, Shah N, LeBien TW. Characterization of apoptotic pathways induced following bone marrow stromal cell-deprivation of the human pre-B ALL cell line BLIN-2. In preparation.
210. Shah N, Oseth LL, Hirsch BA, LeBien TW. Analysis of the bone marrow stromal cell dependency of novel human B-lineage ALL cell lines. In preparation.
211. Glimcher LH, Singh H. Transcription factors in lymphocyte development: T and B cells get together. Cell. 1999;96:13-23.
212. Engel I, Murre C. Transcription factors in hematopoiesis. Curr Opin Genet Dev. 1999;9:575-579.
213. Rolink AG, Nutt SL, Melchers F, Busslinger M. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors. Nature. 1999;401:603-606.
214. Nutt SL, Heavey B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999; 401:556-562.
215. Jaleco AC, Stegmann AP, Heemskerk MH, et al. Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3. Blood. 1999;94:2637-2646.
216. Minegishi Y, Rohrer J, Coustan-Smith E, et al. An essential role for BLNK in human B cell development. Science. 1999;286:1954-1957.
217. Pappu R, Cheng AM, Li B, et al. Requirement for B cell linker protein (BLNK) in B cell development. Science 1999;286:1949-1954.
218. Jumaa H, Wollscheid B, Mitterer M, Wienands J, Reth M, Nielsen PJ. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity. 1999;11:547-554.
219. Marshall E. Do-it-yourself gene watching. Science. 1999;286:444-447.
220. Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999;286:531-537.