PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

Blood

Volumn 96, Issue 8, 2000, Pages 2641-2648

  Zhang, P ^a   Zhang, X ^a   Iwama, A ^a   Yu, C ^a   Smith, K A ^a   Mueller, B U ^a   Narravula, S ^a   Torbett, B E ^a   Orkin, S H ^a   Tenen, D G ^a  

^a HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ESTRADIOL; ESTROGEN RECEPTOR; HEMIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG; ZINC SULFATE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; DNA BINDING; ELECTROPHORETIC MOBILITY; ERYTHROID CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

EID: 0034667672     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.8.2641.h8002641_2641_2648     Document Type: Article

References (51)

1. Regulatory interactions between transcription factors and their role in hematopoietic lineage determination
2. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
3. PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity
4. Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator
5. C-Jun is a JNK-independent coactivator of the PU.1 transcription factor
6. GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line
7. The C-terminal zinc linger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line
8. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts
9. Overexpression of PU.1 induces growth and differentiation inhibition and apoptotic cell death in murine erythroleukemia cells
10. Direct interaction of hematopoietic transcription factors PU 1 and GATA-1: Functional antagonism in erythroid cells
11. Negative crosstalk between hematopoietic regulators: GATA proteins repress PU.1
12. Transcription factors, normal myeloid development, and leukemia
13. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1 dependent transcription
14. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
15. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
16. A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction
17. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1
18. Expression of GATA-1 mRNA in human myeloid leukemic cells
19. Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
20. The Ets-related transcription factor PU.1 immortalizes erythroblasts
21. Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation
22. GATA-binding transcription factors in hematopoietic cells
23. Spi-1/PU.1 transgenic mice develop multistep erythroleukemias
24. Cytomegalovirus IE2 protein stimulates interleukin 1beta gene transcription via tethering to Spi-1/PU.1
25. Reduction of DNA binding activity of the GATA-1 transcription factor in the apoptotic process induced by overexpression of PU.1 in murine erythroleukemia cells
26. Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein
27. Differentiation of K562 leukemia cells along erythroid, macrophage, and megakaryocyte lineages
28. Differentiation in erythroleukemic cells and their somatic hybrids
29. Isolation of biologically active ribonucleic acid from sources rich in ribonuclease
30. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction
31. Rapid reprogramming of globin gene expression in transient heterokaryons
32. Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B
33. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
34. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
35. PU.1 (Spi-1) autoregulates its expression in myeloid cells
36. Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter
37. PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation
38. Multiple functional domains of AML1: PU.1 and C/EBP cooperate with different regions of AML1
39. Use of a promoter-less Renilla luciferase vector as an internal control plasmid for transient co-transfection assays of Ras-mediated transcription activation
40. Stimulation of macrophages by LPS alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II
41. Myeloid development is selectively disrupted in PU.1 null mice
42. The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter
43. Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains
44. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
45. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation
46. Characterization of the myeloid-specific CD11b promoter
47. The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB
48. Phosphorylation of GATA-1 increases its DNA-binding affinity and is correlated with induction of human K562 erythroleukaemia cells
49. Regulation of activity of the transcription factor GATA-1 by acetylation
50. Multilineage gene expression precedes commitment in the hematopoietic system
51. The expression pattern of erythrocyte/megakaryocyte-related transcription factors GATA-1 and the stem cell leukemia gene correlates with hematopoietic differentiation and is associated with outcome of acute myeloid leukemia