Haemangioblast commitment is initiated in the primitive streak of the mouse embryo

Nature

Volumn 432, Issue 7017, 2004, Pages 625-630

  Huber, Tara L ^a   Kouskoff, Valerie ^a,b   Fehling, H Joerg ^c   Palis, James ^d   Keller, Gordon ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY HOSPITAL ULM   (Germany)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BLOOD; DNA; FLUORESCENCE; FREQUENCIES; MAPPING; PROTEINS;

BLAST COLONY-FORMING CELL (BL-CFC); EMBROYNIC STEM (ES) CELLS; HAEMANGIOBLAST;

CELLS;

COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN;

EMBRYO;

ANIMAL CELL; ARTICLE; BRACHYURY GENE; CELL DIFFERENTIATION; COLONY FORMING CELL; CONTROLLED STUDY; DILUTION; EMBRYO; FEMALE; FLK 1 GENE; GASTRULATION; GENE; GENE LOCUS; GENE MAPPING; HEMANGIOBLAST; HEMATOPOIETIC CELL; MALE; MESODERM; MOUSE; NONHUMAN; PRIMITIVE STREAK; PRIORITY JOURNAL; STEM CELL; YOLK SAC;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CLONE CELLS; EMBRYO; FEMALE; GASTRULA; HEMANGIOBLASTOMA; HEMATOPOIETIC STEM CELLS; MALE; MESODERM; MICE; YOLK SAC;

ANIMALIA; MAMMALIA;

EID: 10344247125     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03122     Document Type: Article

References (28)

1. Choi, K., Kennedy, M., Kazarov, A., Papadimitriou, J. C. & Keller, G. A common precursor for hematopoietic and endothelial cells. Development 125, 725-732 (1998).
2. Kennedy, M. et al. A common precursor for primitive and definitive hematopoiesis. Nature 386, 488-493 (1997).
3. Millauer, B. et al. High affinity VEGF binding and develop mental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835-846 (1993).
4. Yamaguchi, T. P., Dumont, D. J., Conlon, R. A., Breitman, M. L. & Rossant, J. flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development 118, 489-498 (1993).
5. Kabrun, N. et al. Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development 124, 2039-2048 (1997).
6. Kallianpur, A. R., Jordan, J. E. & Brandt, S. J. The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis. Blood 83, 1200-1208 (1994).
7. Silver, L. & Palis, J. Initiation of murine embryonic erythropoiesis: a spatial analysis. Blood 89, 1154-1164 (1997).
8. Breier, G. et al. Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood 87, 630-641 (1996).
9. Orkin, S. H. GATA-binding transcription factors in hematopoietic cells. Blood 80, 575-581 (1992).
10. Robertson, S. M., Kennedy, M., Shannon, J. M. & Keller, G. A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1. Development 127, 2447-2459 (2000).
11. Wilkinson, D. G., Bhatt, S. & Herrmann, B. G. Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343, 657-659 (1990).
12. Lyons, I.et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 9, 1654-1666 (1995).
13. Sitzmann, J., Noben-Trauth, K. & Klempnauer, K.-H. Expression of mouse c-myb during embryonic development. Oncogens 11, 2273-2279 (1995).
14. Zhang, I. C et al. Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Mol. Cell. Biol. 21, 1336-1344 (2001).
15. Duband, J. L., Gimona, M., Scatena, M., Sartore, S. & Small, J. V. Calponin and SM 22 as differentiation markers of smooth muscle: spatiotemporal distribution during avian embryonic development. Differentiation 55, 1-11 (1993).
16. Ema, M. et al. Combinatorial effects of Flk1 and Tall on vascular and hematopoietic development in the mouse. Genes Dev. 17, 380-393 (2003).
17. Fehling, H. J. et al. Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation. Development 130, 4217-4227 (2003).
18. Herrmann, B. G. Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos. Development 113, 913-917 (1991).
19. Biben, C. et al. Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev. Biol. 194, 135-151 (1998).
20. Belo, J. A. et al. Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev. 68, 45-57 (1997).
21. Saga, Y. et al. MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. Development 122, 2769-2778 (1996).
22. Shalaby, F. et al. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 89, 981-990 (1997).
23. Kinder, S. J. et al. The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. Development 126, 4691-4701 (1999).
24. Cumano, A., Dieterlen-Lièvre, F. & Godin, I. Lymphoid potential, probed before circulation in mouse is restricted to caudal intraembryonic splanchnopleura. Cell 86, 907-916 (1996).
25. Cumano, A., Ferraz, J., Klaine, M., Di Santo, J. & Godin, I. Intraembryonic, but not yolk sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution. Immunity 15, 477-485 (2001).
26. Palis, J., Roberston, S., Kennedy, M., Wall, C. & Keller, G. Development of erythroid and myeloid progenitors tn the yolk sac and embryo proper of the mouse. Development 126, 5073-5084 (1999).
27. Downs, K. M. & Davies, T. Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Development 118, 1255-1266 (1993).
28. Brady, G. & Iscove, N. N. Construction of cDNA libraries from single cells. Methods Enzymol. 225, 611-623 (1993).