Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase

Blood

Volumn 90, Issue 1, 1997, Pages 111-125

  Rappold, Irene ^b   Ziegler, Benedikt L ^b   Köhler, Iris ^b   Marchetto, Sylvie ^b   Rosnet, Olivier ^b   Birnbaum, Daniel ^b   Simmons, Paul J ^b   Zannettino, Andrew C W ^b   Hill, Beth ^b   Neu, Stefan ^b   Knapp, Walter ^b   Alitalo, Riitta ^b   Alitalo, Kari ^b   Ullrich, Axel ^b   Kanz, Lothar ^b   Bühring, Hans Jörg ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; LYMPHOCYTE ANTIGEN; PROTEIN TYROSINE KINASE;

ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW CELL; CELL SELECTION; COLONY FORMING UNIT GEMM; COLONY FORMING UNIT GM; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NEWBORN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS REGULATION; RECEPTOR DENSITY; UMBILICAL CORD BLOOD;

BONE MARROW; BONE MARROW CELLS; CELL DIFFERENTIATION; FEMALE; FETAL BLOOD; FLOW CYTOMETRY; FMS-LIKE TYROSINE KINASE 3; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOPHENOTYPING; INFANT, NEWBORN; PREGNANCY; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE;

EID: 18344418672     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Civin C, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH: Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J Immunol 133:157, 1984
2. Andrews RG, Singer JW, Bernstein ID: Monoclonal antibody 12-8 recognizes a 115 kD molecule present on both unipotent and multipotent hematopoietic progenitor cells from human bone marrow. Blood 67:842, 1986
3. Sutherland DR, Keating A: The CD34 antigen: Structure, biology, and potential clinical applications. J Hemother 1:115, 1992
4. Simmons DL, Satterthwaite AB, Tenen DG, Seed B: Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. J Immunol 148:267, 1992
5. Dunbar CE, Cottler-Fox M, Oshaugnessy JA, Doren S, Carter C, Berenson R, Brown S, Moen RC, Greenblatt J, Stewart FM, Leitmann SF, Wilson WH, Cowan K, Young NS, Nienhuis AW: Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood 85:3048, 1995
6. Ploemacher RE, van der Sluijs JP, van Beurden CAJ, Baert MRM, Chan PL: Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse. Blood 78:2527, 1991
7. + hematopoietic stem cells. Blood 83:3758, 1994
8. Fraser CC, Kaneshima H, Hansteen G, Kilpatrick M, Hoffman R, Chen BP: Human allogeneic stem cell maintenance and differentiation in a long-term multilineage SCID-hu graft. Blood 86:1680, 1995
9. Sherr CJ, Rettenmeier CW, Sacca R, Roussel R, Look AT, Stanley ER: The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor. Cell 41:665, 1985
10. Ashman LK, Cambareri AC, To LB, Levinsky RJ, Juttner CA: Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow. Blood 78:30, 1991
11. c-kit) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of non-lymphoblastic leukemic cells. Leukemia 5:854, 1991
12. Rosnet O, Bühring H-J, Marchetto S, Rappold I, Lavagna C, Sainty D, Amoulet C, Chabannon C, Kanz L, Birnbaum D: Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia 10:238, 1996
13. Zeigler F, Bennet B, Jordan C, Spencer S, Baumheuter S, Carroll K, Hooley J, Bauer K, Matthews W: Cellular and molecular characterization of the role of the FLK2/FLT3 receptor tyrosine kinase in hematopoietic stem cells. Blood 84:2422, 1994
14. Birg F, Courcoul M, Rosnet O, Bardin F, Pébusque MJ, Marchetto S, Tabilio A, Mannoni P, Birnbaum D: Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood 80:2584, 1992
15. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203, 1990
16. Bühring HJ, Birnbaum D, Brasel K, Civin CI, Götze K, Lyman S, Rappold I, Rosnet O: CD135 workshop panel report, in Kishimoto T, Goyert SM, Kikutani H, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, von dem Borne AEGK, Zola H (eds): Leucocyte Typing VI. New York, NY, Garland Publishing, 1997 (in press)
17. Bühring HJ, Müller T, Herbst R, Cole S, Rappold I, Schuller W, Zhu X, Fritzsche U, Faul C, Armeanu S, Ullrich A, Klein G, Schmidt H: The adhesion molecule E-cadherin and a surface antigen recognized by the antibody 9C4 are selectively expressed on erythroid cells of defined maturational stages. Leukemia 10:106, 1996
18. Papayannopoulou T, Brice M, Broudy VC, Zsebo KM: Isolation of c-kit receptor expressing cells from bone marrow, peripheral blood and fetal liver: Functional properties and composite antigenic profile. Blood 78:1403, 1991
19. Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K: A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol Cell Biol 12:1698, 1992
20. Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, Gridley T, Wolburg H, Risau W, Qin Y: Tie1 and Tie2 receptor tyrosine kinases are important for distinct aspects of blood vessel formation. Nature 376:70, 1995
21. Batard P, Sansilvestri P, Scheinecker C, Knapp W, Debili N, Vainchenker W, Bühring HJ, Monier MN, Kukk E, Partanen J, Matikainen MT, Alitalo R, Hatzfeld J, Alitalo K: The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells. Blood 87:2212, 1996
22. Hashiyama H, Iwama A, Oshiro K, Kuozumi K, Yasunaga K, Shimizu Y, Masuho Y, Matsuda I, Yamaguchi N, Suda T: Pre-dominant expression of a receptor tyrosine kinase, tie in hematopoietic stem cells and B cells. Blood 87:93, 1996
23. Craig W, Kay R, Cutler RL, Lansdorp PM: Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med 177:1331, 1993
24. Sutherland DR, Yeo EL: CDw109 cluster report, in Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder TF, Todd RF (eds): Leucocyte Typing V. Oxford, UK, Oxford University Press, 1995, p 1767
25. Baum CM, Weissman IL, Tsukamoto AS, Buckle AM, Peault B: Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA 89:2804, 1992
26. Sutherland DR, Yeo EL: Cluster report: CD109, in Kishimoto T, Goyert SM, Kikutani H, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, von dem Borne AEGK, Zola, H (eds): Leucocyte Typing VI. New York, NY, Garland Publishing, 1997 (in press)
27. Zannettino ACW, Rappold I, Bühring HJ, Watt S, Benton A, Niutta S, Simmons PJ: CD164 (MGC-24v) workshop panel report, in Kishimoto T, Goyert SM, Kikutani H, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, von dem Borne AEGK, Zola, H (eds): Leucocyte Typing VI. New York, NY, Garland Publishing, 1997 (in press)
28. Masuzawa Y, Miyauchi T, Hamanoue M, Ando S, Yoshida J, Takao S, Shimazu H, Adachi M, Muramatsu T: A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: Sequence analysis and examination of gene expression. J Biochem 112:609, 1992
29. Bühring HJ, Zannettino A, Scheding S, Rappold I, Simmons P, Kanz L: Peanut agglutinin binding protein MGC-24 is a mucin preferentially expressed on erythroid cells and a subset of CD34+ bone marrow cells. Blood 86:2624a, 1995 (abstr, suppl 1)
30. Zannettino ACW, Bühring HJ, Niutta S, Ashman LK, Kanz L, Simmons PJ: Identification & functional cloning of MGC-24, a mucin-like molecule expressed by haemopoietic progenitors and bone marrow stromal cells: A negative regulator of haemopoiesis. Blood: 86:2350a, 1995 (abstr, suppl 1).
31. Zannettino ACW, Bühring HJ, Watt SM, Benton AM, Niutta S, Simmons PJ: Identification and functional cloning of MGC-24v (CD 164), a mucin-like molecule expressed by haemopoietic progenitors and bone marrow stromal cells. (submitted)
32. Watt SM, Bühring HJ, Chan YS, Lee-Prudhoe J, Rappold I, Jones T, Benton MA, Zannettino ACW, Simmons PJ, Sheer D, Butler L: CD 164 a mucin-like inhibitory receptor on CD34+ and erythroid cell subsets is located on human chromosome 6q21. (submitted)
33. Rossner M, McArthur G, Allen J, Metcalf D: Fms-like tyrosine kinase 3 catalytic domain can transduce a proliferative signal in FDCP1 cells that is qualitatively similar to the signal delivered by C-fms. Cell Growth Differ 5:549, 1994
34. Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR: A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65:1143, 1992
35. Brasel K, Escobar S, Anderberg R, de Vries P, Gruss HJ, Lyman SD: Expression of the FLT3 receptor and its ligand on hematopoietic cells. Leukemia 9:1212, 1995
36. Drexler HG: Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia 10:588, 1996
37. Turner AM, Lin NL, Issarachai S, Lyman SD, Broudy VC: FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells. Blood 88:3383, 1996
38. Rosnet O, Schiff C, Pebusque M, Marchetto S, Tonnelle C, Toiron Y, Birg F, Birnbaum D: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic stem cells. Blood 82:1110, 1993
39. Matsuo Y, Adachi T, Tsubota T, Imanishi J, Minowada J. Establishment and characterization of a novel megakaryoblastoid cell line MOLM-1 from a patient with chronic myelogenous leukemia. Hum Cell 4:261, 1991
40. Yarden Y, Kuang WJ, Yang FT, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A: Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6:3341, 1987
41. Ashman LK, Cambareri AC, Ngoyen L, Bühring HJ: CD117 (c-kit) panel report, in Kishimoto T, Goyert SM, Kikutani H, Mason DY, Miyasaka M, Moretta L, Okumura K, Shaw S, Springer TA, Sugamura K, von dem Borne AEGK, Zola H (eds): Leucocyte Typing VI. New York, NY, Garland Publishing, 1997 (in press)
42. Breems DA, Blokland EAW, Neben S, Ploernacher RE: Frequency analysis of human primitive haematopoietic stem cell subsets using a cobble stone area forming cell assay. Leukemia 8:1095, 1994
43. Finney DJ: Probit Analysis. Cambridge, UK, Cambridge University Press, 1971
44. Thoma SJ, Lamping CP, Ziegler BL: Phenotype analysis of hematopoietic CD34+ cell populations derived from human umbilical cord blood using flow cytometry and cDNA-polymerase chain reaction. Blood 83:2103, 1994
45. Ziegler BL, Thoma SJ, Lamping CP, Valtieri M, Müller R, Samoggia P, Bühring HJ, Peschle C, Fliedner TM: Surface antigen expression on CD34+ cord blood cells: Comparative analysis by flow cytometry and limiting dilution (LD) RT-PCR of chymopapain-treated or untreated cells. Cytometry 25:46, 1996
46. - hematopoietic stem cells. Blood 83:1515, 1994
47. - bone marrow cells contain progenitor cells capable of self-renewal, multilineage differentiation, and long-term in vitro hematopoiesis. Blood Cells 17:287, 1991
48. - cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow. J Exp Med 175:1501, 1992
49. + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA 91:459, 1994
50. Lyman SD, James L, Johnson L, Brasel K, de Vries P, Escobar SS, Downey H, Splett RR, Beckmann MP, McKenna HJ: Cloning of the human homologue of the murine flt3 ligand: A growth factor for early hematopoietic progenitor cells. Blood 83:2795, 1994
51. Hunte BE, Hudak S, Campbell D, Xu Y, Rennick D: flk2/ flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors. J Immunol 156:489, 1995
52. + bone marrow progenitor cells in vitro. Blood 87:1317, 1996
53. Gabbianelli M, Pelosi E, Montesoro E, Valtieri M, Luchetti L, Samoggia P, Vitelli L, Barberi T, Testa U, Lyman SD, Peschle C: Multi-level effects of flt3 ligand on human hematopoiesis: Expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors. Blood 86:1661, 1995
54. Petzer AL, Hogge DE, Lansdorp PM, Reid DS, Eaves CJ: Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci USA 93:1470, 1996
55. + bone marrow cells. Blood 84:1473, 1994
56. high cells. Blood 82:3283, 1993
57. + human marrow cells that express low levels of kit protein are enriched for long-term marrow-engrafting cell. Blood 87:4136, 1996
58. Sutherland DR, Yeo EL, Stewart AK, Nayar R, DiGiusto R, Zanjani E, Hoffman R, Murray LJ: Identification of CD34+ subsets after glycoprotease selection: Engraftment of CD34+Thy-1+Lin-stem cells in fetal sheep. Exp Hematol 24:795, 1996
59. Bock TA, Orlic D, Dunbar CE, Broxmeyer HE, Bodine DM: Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes. J Exp Med 182:2037, 1995
60. Mackarehtschian K, Hardin JD, Moore KA, Boast S, Goff SP, Lemischka IR: Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3:147, 1995